I am mainly interested in studying the biomechanical factors triggering knee osteoarthritis. For that, we have developed a finite element-based workflow to model hundreds of knees within a reasonable computation time. Each model accounts for the personalized characteristics of subjects that may be linked to the risk of developing this painful and irreversible disease. Our ultimate goal is to provide patients and clinicians with a tool to envision preventive treatments.
Atlas-based finite element analyses with simpler constitutive models predict personalized progression of knee osteoarthritis: data from the osteoarthritis initiativeMononen, Mika E; Paz, Alexander; Liukkonen, Mimmi K; Turunen, Mikael J. 2023. Scientific reports. 13: . 8888
Towards a Transferable Modeling Method of the Knee to Distinguish Between Future Healthy Joints from Osteoarthritic Joints: Data from the Osteoarthritis InitiativePaz, Alexander; García, José J; Korhonen, Rami K; Mononen, Mika E. 2023. Annals of biomedical engineering. 51: 2192-2203
A novel knee joint model in FEBio with inhomogeneous fibril-reinforced biphasic cartilage simulating tissue mechanical responses during gait: data from the osteoarthritis initiativePaz, Alexander; Orozco, Gustavo A; Tanska, Petri; García, José J; Korhonen, Rami K. Mononen, Mika E. 2022. Computer methods in biomechanics and biomedical engineering. [Published online: 05 Sep 2022]: 1-15
Expediting Finite Element Analyses for Subject-Specific Studies of Knee Osteoarthritis: A Literature ReviewPaz, Alexander; Orozco, Gustavo; Korhonen, Rami; García, José Jaime; Mononen, Mika. 2021. Applied sciences. 11: 24