Anna-Kaisa Ruotsalainen

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Novel genetic atherosclerosis risk factors and future therapeutic targets in CVD.

Research groups

Molecular Medicine 01.01.1995 -

Keywords

atherosclerosis cardiovascular diseases lipidmetabolism low-grade inflammation macrophages metabolic diseases mouse models

Publications

18/18 items

Deletion of the Murine Ortholog of the Human 9p21.3 Locus Leads to Insulin Resistance and Obesity in Hypercholesterolemic Mice
Kettunen, Sanna; Suoranta, Tuisku; Beikverdi, Sadegh; Heikkilä, Minja; Slita, Anna; Räty, Iida; Ylä-Herttuala, Elias; Öörni, Katariina; Ruotsalainen, Anna-Kaisa; Ylä-Herttuala, Seppo. 2024. Cells. 13: A1 Journal article (refereed), original research
Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity
Kettunen, Sanna; Ruotsalainen, Anna-Kaisa; Örd, Tiit; Suoranta, Tuisku; Heikkilä, Janne; Kaikkonen, Minna U.; Laham-Karam, Nihay; Ylä-Herttuala, Seppo. 2023. Frontiers in cardiovascular medicine. 10: . 1113890 A1 Journal article (refereed), original research
Genetic variation is a key determinant of chromatin accessibility and drives differences in the regulatory landscape of C57BL/6J and 129S1/SvImJ mice
Mononen, Juho; Taipale, Mari; Malinen, Marjo; Velidendla, Bharadwaja; Niskanen, Einari; Levonen, Anna-Liisa; Ruotsalainen, Anna-Kaisa; Heikkinen, Sami. 2023. Nucleic acids research. 2024; 52: 2904-2923 A1 Journal article (refereed), original research
Western Diet Decreases Hepatic Drug Metabolism in Male LDLr−/−ApoB100/100 Mice
Koponen, Markus; Rysä, Jaana; Ruotsalainen, Anna-Kaisa; Kärkkäinen, Olli; Juvonen, Risto O. 2023. Journal of nutrition and metabolism. 2023: A1 Journal article (refereed), original research
RNA interference-based therapies for the control of atherosclerosis risk factors
Kettunen, Sanna; Ruotsalainen, Anna-Kaisa; Ylä-Herttuala, Seppo. 2022. Current opinion in cardiology. 37: 364-371 A2 Review article, Literature review, Systematic review
Menaquinone 4 increases plasma lipid levels in hypercholesterolemic mice
Weisell, Jonna; Ruotsalainen, Anna-Kaisa; Näpänkangas, Juha; Jauhiainen, Matti; Rysä, Jaana. 2021. Scientific reports. 11: 3014 A1 Journal article (refereed), original research
Novel RNAi-Based Therapies for Atherosclerosis
Ruotsalainen, Anna-Kaisa; Mäkinen, Petri; Ylä-Herttuala, Seppo. 2021. Current atherosclerosis reports. 23: 45 A2 Review article, Literature review, Systematic review
SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice
Gurzeler, Erika; Ruotsalainen, Anna-Kaisa; Laine, Anssi; Valkama, Teemu; Kettunen, Sanna; Laakso, Markku; Ylä-Herttuala, Seppo. 2021. PLoS ONE. 16: e025840 A1 Journal article (refereed), original research
LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis: Insight from Mouse Models
Cedo, Lidia; Metso, Jari; Santos, David; García-León, Annabel; Plana, Nuria; Sabate-Soler, Sonia; Rotllan, Noemi; Rivas-Urbina, Andrea; Mendez-Lara, Karen A; Tondo, Mireia; Girona, Josefa; Julve, Josep; Pallarès, Victor; Benitez-Amado, Aleyda; Llorente Cortes, Vicenta; Pérez, Antonio; Gómez-Coronado, Diego; Ruotsalainen, Anna-Kaisa; Levonen, Anna-Liisa; Sanchez-Quesada, Jose Luis et al.. 2020. Circulation research. 127: 778-792 A1 Journal article (refereed), original research
Nucleic Acid-Based Therapies for Atherosclerosis
Mäkinen, P; Ruotsalainen, AK; Ylä-Herttuala, S. 2020. Current atherosclerosis reports. 22: 10 A2 Review article, Literature review, Systematic review
Characterizing valve dynamics in mice by high-resolution cine-MRI
Weisell, J; Ruotsalainen, AK; Laakso, H; Ylä-Herttuala, E; Näpänkangas, J; Levonen, AL; Liimatainen, T; Rysä, J. 2019. Nmr in biomedicine. 32: e4108 A1 Journal article (refereed), original research
Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. 2018. Redox biology. 2019; 20: 1-12 A1 Journal article (refereed), original research
Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolemic mice
Ruotsalainen, Anna-Kaisa; Lappalainen, Jari P; Heiskanen, Emmi; Merentie, Mari; Näpänkangas, Juha; Lottonen-Raikaslehto, Line; Kansanen, Emilia; Adinolfi, Simone; Kaarniranta, Kai; Ylä-Herttuala, Seppo; Jauhiainen, Matti; Pirinen, Eija; Levonen, Anna-Liisa. 2018. Cardiovascular research. 2019; 115: 243-254 A1 Journal article (refereed), original research
The role of transcription factor Nrf2 in atherogenesis and hepatic steatosis in hypercholesterolemic mouse models
Ruotsalainen, Anna-Kaisa. 2018. Publications of the University of Eastern Finland. Dissertations in Health Sciences G5 Doctoral dissertation (article)
Nitro-Oleic Acid Regulates Endothelin Signaling in Human Endothelial Cells
Kansanen Emilia, Kuosmanen Suvi M, Ruotsalainen Anna-Kaisa, Hynynen Heidi, Levonen Anna-Liisa. 2017. Molecular pharmacology. 92: 481-490 A1 Journal article (refereed), original research
The absence of macrophage Nrf2 promotes early atherogenesis
Ruotsalainen AK, Inkala M, Partanen ME, Lappalainen JP, Kansanen E, Mäkinen PI, Heinonen SE, Laitinen HM, Heikkilä J, Vatanen T, Hörkkö S, Yamamoto M, Ylä-Herttuala S, Jauhiainen M, Levonen AL. 2013. Cardiovascular research. : 107-15 A1 Journal article (refereed), original research
Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele
Dhungana H, Rolova T, Savchenko E, Wojciechowski S, Savolainen K, Ruotsalainen AK, Sullivan PM, Koistinaho J, Malm T. 2013. Journal of neuroinflammation. 2013 Aug 20;10(1):102: -- A1 Journal article (refereed), original research
Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment
Leinonen HM, Ruotsalainen AK, Määttä AM, Laitinen HM, Kuosmanen SM, Kansanen E, Pikkarainen JT, Lappalainen JP, Samaranayake H, Lesch HP, Kaikkonen MU, Ylä-Herttuala S, Levonen AL. 2012. Cancer research. 2012 Oct 9. [Epub ahead of print]: - - A1 Journal article (refereed), original research

Refine your search

Anna-Kaisa Ruotsalainen

Research groups

Keywords

Deletion of the Murine Ortholog of the Human 9p21.3 Locus Leads to Insulin Resistance and Obesity in Hypercholesterolemic Mice

Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity

Genetic variation is a key determinant of chromatin accessibility and drives differences in the regulatory landscape of C57BL/6J and 129S1/SvImJ mice

Western Diet Decreases Hepatic Drug Metabolism in Male LDLr−/−ApoB100/100 Mice

RNA interference-based therapies for the control of atherosclerosis risk factors

Menaquinone 4 increases plasma lipid levels in hypercholesterolemic mice

Novel RNAi-Based Therapies for Atherosclerosis

SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice

LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis: Insight from Mouse Models

Nucleic Acid-Based Therapies for Atherosclerosis

Characterizing valve dynamics in mice by high-resolution cine-MRI

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolemic mice

The role of transcription factor Nrf2 in atherogenesis and hepatic steatosis in hypercholesterolemic mouse models

Nitro-Oleic Acid Regulates Endothelin Signaling in Human Endothelial Cells

The absence of macrophage Nrf2 promotes early atherogenesis

Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele

Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment