Anna-Kaisa Ruotsalainen
Senior Researcher
Academy Research Fellow, Principal Investigator and Head of Cell Metabolism lab
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
[email protected] | +358 50 323 1041
My research group explores how cells adapt their metabolism under stress and how these changes influence tissue repair and regeneration in cardiometabolic diseases. We aim to uncover the underlying mechanisms of impaired tissue regeneration in chronic diseases, ultimately aiming to improve treatment options for cardiovascular and chronic liver diseases. In the RCF Finland funded GrowMeLiver and Novo Nordisk Foundation funded LiverXComm projects (Emerging Investigator Grant in Endocrinology and Metabolism) explore cell organelle interactions and their regulatory gene networks in the hepatocyte plasticity and metabolic reprogramming to understand the disturbed liver regeneration capacity in MASH. As part of the GeneCellNano Flagship Program, we strive to develop RNA therapies for cardiometabolic diseases. We are also part of MSCA MIRACLE Doctoral Network where we aim to better understand the metabolic programming in inflammatory cells.
Activities
www.satyry.fi
www.genecellnano.fi
Publications
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Efficiency of Lentiviral Vectors Pseudotyped with LCMV-G in Gene Transfer to Ldlr−/−ApoB100/100 Mice
Nousiainen, Alisa; Ruotsalainen, Anna-Kaisa; Hokkanen, Krista; Laidinen, Svetlana; Tawfek, Ahmed; Schenkwein, Diana; Ylä-Herttuala, Seppo, 2026, Genes, 17, 1, 60. A1 Journal article (refereed), original research -
Genetic variation shapes the chromatin accessibility landscape and transcriptional responses in mouse adipose tissue
Mononen, Juho; Taipale, Mari; Malinen, Marjo; Levonen, Anna-Liisa; Ruotsalainen, Anna-Kaisa; Norton, Luke; Heikkinen, Sami, 2026, PLoS genetics, 22, 1, e1011716. A1 Journal article (refereed), original research -
Low and High Pressor Doses of Ang II Lead to Two Distinct Phenotypes of Hypertensive Heart Disease in Mice
Törmä, Diana; Suoranta, Tuisku; Rinta‐Harri, Mimmi; Hytönen, Jarkko; Ylä‐Herttuala, Seppo; Ruotsalainen, Anna‐Kaisa, 2026, Apmis, 134, 1, e70132. A1 Journal article (refereed), original research -
Simultaneous 3‐D Adiabatic T1ρ, T2*, and Quantitative Susceptibility Mapping for Characterization of Myocardial Infarction in Ex Vivo Mouse
Räty, Iida; Nykänen, Olli; Kettunen, Sanna; Laidinen, Svetlana; Ruotsalainen, Anna‐Kaisa; Nissi, Mikko J; Ylä‐Herttuala, Elias, 2026, Nmr in biomedicine, 39, 10, e70378. A1 Journal article (refereed), original research -
The co-delivery of Programmed Death 1 ligands enhances and prolongs rAAV-mediated gene expression in pre-immunized mice
Käyhty, Piia; Nieminen, Tiina; Eriksson, Reetta AE.; Tumelius, Ritva; Tawfek, Ahmed; Laidinen, Svetlana; Ruotsalainen, Anna-Kaisa; Bailey, Aubrey; Galibert, Lionel; Lesch, Hanna P; Ylä-Herttuala, Seppo; Airenne, Kari J, 2026, Gene therapy, 33, 2, 127-137. A1 Journal article (refereed), original research -
Myocardial infarction activates the 9p21.3 orthologous locus expression, but its absence does not alter cardiac pathophysiology in ischemia
Kettunen, Sanna; Slita, Anna; Suoranta, Tuisku; Räty, Iida; Laidinen, Svetlana; Ylä‐Herttuala, Elias; Ruotsalainen, Anna‐Kaisa; Ylä‐Herttuala, Seppo, 2025, Physiological reports, 13, 10, 1-15. A1 Journal article (refereed), original research -
Single-cell to pre-clinical evaluation of Trem2, Folr2, and Slc7a7 as macrophage-associated biomarkers for atherosclerosis
Örd, Tiit; Palani, Senthil; Giroud Gerbetant, Judith; Bodoy, Susanna; Lönnberg, Tapio; Niskanen, Henri; Ravindran, Aarthi; Holappa, Lari; Chemaly, Melody; Taipale, Mari; Õunap, Kadri; Haikonen, Retu; Talukdar, Husain; Sukhavasi, Katyayani; Liljenbäck, Heidi; Virta, Jenni; Ruotsalainen, Anna-Kaisa; Pierrot-Blanchet, Clara; Miner, Maxwell W G; Moisio, Olli; Rajala, Noora; Li, Xiang-Guo; Low, Philip S; Saraste, Antti; Heinäniemi, Merja; Ylä-Herttuala, Seppo; Björkegren, Johan L M; Hedin, Ulf; Matic, 2025, Cardiovascular research, 121, 16, 2503-2519. A1 Journal article (refereed), original research -
The mechanisms of Chr.9p21.3 risk locus in coronary artery disease – where are we today?
Ruotsalainen, Anna-Kaisa; Kettunen, Sanna; Suoranta, Tuisku; Kaikkonen, Minna U; Ylä-Herttuala, Seppo; Aherrahrou, Rédouane, 2025, American journal of physiology : heart and circulatory physiology, 328, 2, H196-H208. A2 Review article, Literature review, Systematic review -
Deletion of the Murine Ortholog of the Human 9p21.3 Locus Leads to Insulin Resistance and Obesity in Hypercholesterolemic Mice
Kettunen, Sanna; Suoranta, Tuisku; Beikverdi, Sadegh; Heikkilä, Minja; Slita, Anna; Räty, Iida; Ylä-Herttuala, Elias; Öörni, Katariina; Ruotsalainen, Anna-Kaisa; Ylä-Herttuala, Seppo, 2024, Cells, 13, 11, 983. A1 Journal article (refereed), original research -
Ex vivo imaging of subacute myocardial infarction with ultra-short echo time 3D quantitative T1- and T1ρ-mapping magnetic resonance imaging in mice
Räty, Iida; Aarnio, Antti; Nissi, Mikko J; Kettunen, Sanna; Ruotsalainen, Anna-Kaisa; Laidinen, Svetlana; Ylä-Herttuala, Seppo; Ylä-Herttuala, Elias, 2024, European heart journal : imaging methods and practice, 3, 1, 1-10. A1 Journal article (refereed), original research