Esa Hämäläinen

Associations of polymetabolic risk of high maternal pre-pregnancy body mass index with pregnancy complications, birth outcomes, and early childhood neurodevelopment: findings from two pregnancy cohorts

Girchenko, Polina; Lahti-Pulkkinen, Marius; Hämäläinen, Esa; Laivuori, Hannele; Villa, Pia M; Kajantie, Eero; Räikkönen, Katri. 2024. Bmc pregnancy and childbirth. 24:

A Possible Role of Interleukin-18 Binding Protein in Immune Regulation of Postoperative Pain: A Prospective Randomized Clinical Trial

Eskelinen, Maaret; Saimanen, Iina; Pulkkinen, Jukka; Selander, Tuomas; Holopainen, Anu; Hämäläinen, Esa; Eskelinen, Matti. 2023. Anticancer research. 43: 3113-3119

Effect of external sleep disturbance on sleep architecture in perimenopausal and postmenopausal women

Virtanen, I; Polo-Kantola, P; Turpeinen, U; Hämäläinen, E; Kalleinen, N. 2023. Climacteric. 26: 103-109

Effects of letrozole on serum estradiol and estrone in postmenopausal breast cancer patients and tolerability of treatment: a prospective trial using a highly sensitive LC–MS/MS (liquid chromatography–tandem mass spectrometry) method for estrogen measurement

Faltinová, Mária; Vehmanen, Leena; Lyytinen, Heli; Haanpää, Mikko; Hämäläinen, Esa; Tiitinen, Aila; Blomqvist, Carl; Mattson, Johanna. 2023. Breast cancer research and treatment. 201: 425-435

Metabolomic Profiles of Nonobese and Obese Women With Gestational Diabetes

Sormunen-Harju, Heidi; Huvinen, Emilia; Girchenko, Polina V; Kajantie, Eero; Villa, Pia M; Hämäläinen, Esa K; Lahti-Pulkkinen, Marius; Laivuori, Hannele; Räikkönen, Katri; Koivusalo, Saila B. 2023. Journal of clinical endocrinology and metabolism. 108: 2862-2870

Non-suppression of renin by renal cysts in a subset of patients with primary aldosteronism - a prospective observational single center study

Ylänen, Antero; Pörsti, Ilkka; Nevalainen, Riikka; Hinkka, Tero; Huhtala, Heini; Matikainen, Niina; Hämäläinen, Esa; Niemelä, Onni; Nevalainen, Pasi, I. 2023. European journal of endocrinology. 189: 58-66

Effects of rifampicin on porphyrin metabolism in healthy volunteers

Tolonen, Hanna; Ranta, Sirpa; Hämäläinen, Esa; Kauppinen, Raili; Hukkanen, Janne. 2022. Basic and clinical pharmacology and toxicology. 2023; 132: 281-291

Interleukin-18 (IL-18) Cytokine Serum Concentrations Correlate With Pain Scores and the Number of Analgesic Doses Following Surgery

Eskelinen, Maaret; Saimanen, Iina; Selander, Tuomas; Holopainen, Anu; Aspinen, Samuli; Hämäläinen, Esa; Eskelinen, Matti. 2022. Anticancer research. 42: 5521-5526

Maternal early-pregnancy body mass index-associated metabolomic component and mental and behavioral disorders in children

Girchenko, Polina; Lahti-Pulkkinen, Marius; Lipsanen, Jari; Heinonen, Kati; Lahti, Jari; Rantalainen, Ville; Hämäläinen, Esa; Laivuori, Hannele; Villa, Pia M.; Kajantie, Eero; Räikkönen, Katri. 2022. Molecular psychiatry. 27: 4653-4661

Maternal postpartum depressive symptoms partially mediate the association between preterm birth and mental and behavioral disorders in children

Girchenko, Polina; Robinson, Rachel; Rantalainen, Ville Juhani; Lahti-Pulkkinen, Marius; Heinonen-Tuomaala, Kati; Lemola, Sakari; Wolke, Dieter; Schnitzlein, Daniel; Hämäläinen, Esa; Laivuori, Hannele; Villa, Pia M.; Kajantie, Eero; Räikkönen, Katri. 2022. Scientific reports. 12: . 947

Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes

Pervjakova, Natalia; Moen, Gunn-Helen; Borges, Maria-Carolina; Ferreira, Teresa; Cook, James P; Allard, Catherine; Beaumont, Robin N; Canouil, Mickaël; Hatem, Gad; Heiskala, Anni; Joensuu, Anni; Karhunen, Ville; Kwak, Soo Heon; Lin, Frederick T J; Liu, Jun; Rifas-Shiman, Sheryl; Tam, Claudia H; Tam, Wing Hung; Thorleifsson, Gudmar; Andrew, Toby; Auvinen, Juha; Bhowmik, Bishwajit; Bonnefond, Amélie; Delahaye, Fabien; Demirkan, Ayse; Froguel, Philippe; Haller-Kikkatalo, Kadri; Hardardottir, Hildur. 2022. Human molecular genetics. 31: 3377-3391

Primaarin aldosteronismin diagnostiikka ja hoito

Nevalainen, Pasi I; Ylänen, Antero; Hämäläinen, Esa; Pörsti, Ilkka; Matikainen, Niina . 2022. Duodecim. 138: 1721-1732

Quantitative urine proteomics in pregnant women for the identification of predictive biomarkers for preeclampsia

Joenväärä, Sakari; Holm, Matilda; Saraswat, Mayank; Agarwal, Rahul; Tohmola, Tiialotta; Kajantie, Eero; Räikkönen, Katri; Laivuori, Hannele; Villa, Pia M.; Hämäläinen, Esa; Renkonen, Risto. 2022. Translational medicine communications. 7: . 1

Adipose tissue estrogen production and metabolism in premenopausal women

Hetemäki, Natalia; Mikkola, Tomi S; Tikkanen, Matti J; Wang, Feng; Hämäläinen, Esa; Turpeinen, Ursula; Haanpää, Mikko; Vihma, Veera; Savolainen-Peltonen, Hanna. 2021. Journal of steroid biochemistry and molecular biology. 209: 105849

Longitudinal metabolic profiling of maternal obesity, gestational diabetes and hypertensive pregnancy disorders

Kivelä, Jemina; Sormunen-Harju, Heidi; Girchenko, Polina V; Huvinen, Emilia; Stach-Lempinen, Beata; Kajantie, Eero; Villa, Pia M; Reynolds, Rebecca M; Hämäläinen, Esa K; Lahti-Pulkkinen, Marius; Murtoniemi, Katja K; Laivuori, Hannele; Eriksson, Johan G; Räikkönen, Katri; Koivusalo, Saila B. 2021. Journal of clinical endocrinology and metabolism. 106: e4372-e4388

Maternal antenatal stress and mental and behavioral disorders in their children

Tuovinen, Soile; Lahti-Pulkkinen, Marius; Girchenko, Polina; Heinonen, Kati; Lahti, Jari; Reynolds, Rebecca M; Hämäläinen, Esa; Villa, Pia M; Kajantie, Eero; Laivuori, Hannele; Raikkonen, Katri. 2021. Journal of affective disorders. 278: 57-65

Monitoring serum estradiol levels in breast cancer patients during extended adjuvant letrozole treatment after five years of tamoxifen: a prospective trial

Faltinova, Maria; Vehmanen, Leena; Lyytinen, Heli; Haanpää, Mikko; Hämäläinen, Esa; Tiitinen, Aila; Blomqvist, Carl; Mattson, Johanna. 2021. Breast cancer research and treatment. 187: 769-775

Serum Inhibin-A and PAPP-A2 in the prediction of pre-eclampsia during the first and second trimesters in high-risk women

Keikkala, Elina; Forstén, Janina; Ritvos, Olli; Stenman, Ulf-Håkan; Kajantie, Eero; Hämäläinen, Esa; Räikkönen, Katri; Villa, Pia M; Laivuori, Hannele. 2021. Pregnancy hypertension. 25: 116-122

A polyepigenetic glucocorticoid exposure score at birth and childhood mental and behavioral disorders

Suarez, Anna; Lahti, Jari; Lahti-Pulkkinen, Marius; Girchenko, Polina; Czamara, Darina; Arloth, Janine; Malmberg, Anni Lk; Hämäläinen, Esa; Kajantie, Eero; Laivuori, Hannele; Villa, Pia M; Reynolds, Rebecca M; Provençal, Nadine; Binder, Elisabeth B; Räikkönen, Katri. 2020. Neurobiology of stress. 13: 100275

Cord blood DNA methylation reflects cord blood C-reactive protein levels but not maternal levels: a longitudinal study and meta-analysis

Yeung, Edwina H; Guan, Weihua; Zeng, Xuehuo; Salas, Lucas A; Mumford, Sunni L; de Prado Bert, Paula; van Meel, Evelien R; Malmberg, Anni; Sunyer, Jordi; Duijts, Liesbeth; Felix, Janine F; Czamara, Darina; Hämäläinen, Esa; Binder, Elisabeth B; Räikkönen, Katri; Lahti, Jari; London, Stephanie J; Silver, Robert M; Schisterman, Enrique F. 2020. Clinical epigenetics. 12: 60

Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation

Provençal, Nadine; Arloth, Janine; Cattaneo, Annamaria; Anacker, Christoph; Cattane, Nadia; Wiechmann, Tobias; Röh, Simone; Ködel, Maik; Klengel, Torsten; Czamara, Darina; Müller, Nikola S; Lahti, Jari; PREDO team; Räikkönen, Katri; Pariante, Carmine M; Binder, Elisabeth B. 2020. Proceedings of the National Academy of Sciences of the United States of America. 117: 23280-23285

Maternal Hypertensive Pregnancy Disorders and Mental Disorders in Children

Lahti-Pulkkinen, Marius; Girchenko, Polina; Tuovinen, Soile; Sammallahti, Sara; Reynolds, Rebecca M; Lahti, Jari; Heinonen, Kati; Lipsanen, Jari; Hämäläinen, Esa; Villa, Pia M; Kajantie, Eero; Laivuori, Hannele; Räikkönen, Katri. 2020. Hypertension. 75: 1429-1438

Persistently High Levels of Maternal Antenatal Inflammation Are Associated With and Mediate the Effect of Prenatal Environmental Adversities on Neurodevelopmental Delay in the Offspring

Girchenko, Polina; Lahti-Pulkkinen, Marius; Heinonen, Kati; Reynolds, Rebecca M; Laivuori, Hannele; Lipsanen, Jari; Villa, Pia M; Hämäläinen, Esa; Kajantie, Eero; Lahti, Jari; Räikkönen, Katri. 2020. Biological psychiatry. 87: 898-907

Plasma pentraxin 3 is higher in early ovarian hyperstimulation syndrome than in uncomplicated in vitro fertilization cycle of high-risk women

Korhonen, Kati; Unkila-Kallio, Leila; Alfthan, Henrik; Hämäläinen, Esa; Tiitinen, Aila; Mikkola, Tomi; Tapanainen, Juha; Savolainen-Peltonen, Hanna. 2020. Archives of gynecology and obstetrics. 301: 1569-1578

Polygenic Prediction of the Risk of Perinatal Depressive Symptoms

Rantalainen, V; Binder, EB; Lahti-Pulkkinen, M; Czamara, D; Laivuori, H; Villa, PM; Girchenko, P; Kvist, T; Hämäläinen, E; Kajantie, E; Lahti, J; Räikkönen, K. 2020. Depression and anxiety. 37: 862-875

Predisposition to superimposed preeclampsia in women with chronic hypertension: endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort

Bramham, Kate; Villa, Pia M; Joslin, Jennifer R; Laivuori, Hannele; Hämäläinen, Esa; Kajantie, Eero; Räikkönen, Katri; Pesonen, Anukatriina; Seed, Paul; Dalton, R Neil; Turner, Charles; Wong, Max; Von Dadelszen, Peter; Roberts, James M; Poston, Lucilla; Chappell, Lucy C. 2020. Hypertension in pregnancy. 39: 326-335

Saltatory Pattern of Fetal Heart Rate during Labor Is a Sign of Fetal Hypoxia

Tarvonen, Mikko; Sainio, Susanna; Hämäläinen, Esa; Hiilesmaa, Vilho; Andersson, Sture; Teramo, Kari. 2020. Neonatology. 117: 111-117

Kliniskt-kemisk avdelning vid Kuopio universitetssjukhus samt institutionen för klinisk kemi vid Kuopio universitet verksamheten under åren 1959-1995

Penttilä I, Hämäläinen E, Puhakainen E, Rantanen T, Sahlstein R. 1996. Klinisk biokemi i norden. 8: 15-20

Diet and urinary estrogen profile in various populations. A preliminary report

Adlercreutz H, Gorbach SL, Goldin BR, Woods MN, Dwyer JT, Höckerstedt K, Wähälä K, Hase T, Hämäläinen E, Fotsis T. 1994. Polycyclic aromatic compounds. 6: 261-273

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Publications

Associations of polymetabolic risk of high maternal pre-pregnancy body mass index with pregnancy complications, birth outcomes, and early childhood neurodevelopment: findings from two pregnancy cohorts

A Possible Role of Interleukin-18 Binding Protein in Immune Regulation of Postoperative Pain: A Prospective Randomized Clinical Trial

Effect of external sleep disturbance on sleep architecture in perimenopausal and postmenopausal women

Effects of letrozole on serum estradiol and estrone in postmenopausal breast cancer patients and tolerability of treatment: a prospective trial using a highly sensitive LC–MS/MS (liquid chromatography–tandem mass spectrometry) method for estrogen measurement

Metabolomic Profiles of Nonobese and Obese Women With Gestational Diabetes

Non-suppression of renin by renal cysts in a subset of patients with primary aldosteronism - a prospective observational single center study

Effects of rifampicin on porphyrin metabolism in healthy volunteers

Interleukin-18 (IL-18) Cytokine Serum Concentrations Correlate With Pain Scores and the Number of Analgesic Doses Following Surgery

Maternal early-pregnancy body mass index-associated metabolomic component and mental and behavioral disorders in children

Maternal postpartum depressive symptoms partially mediate the association between preterm birth and mental and behavioral disorders in children

Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes

Primaarin aldosteronismin diagnostiikka ja hoito

Quantitative urine proteomics in pregnant women for the identification of predictive biomarkers for preeclampsia

Adipose tissue estrogen production and metabolism in premenopausal women

Longitudinal metabolic profiling of maternal obesity, gestational diabetes and hypertensive pregnancy disorders

Maternal antenatal stress and mental and behavioral disorders in their children

Monitoring serum estradiol levels in breast cancer patients during extended adjuvant letrozole treatment after five years of tamoxifen: a prospective trial

Serum Inhibin-A and PAPP-A2 in the prediction of pre-eclampsia during the first and second trimesters in high-risk women

A polyepigenetic glucocorticoid exposure score at birth and childhood mental and behavioral disorders

Cord blood DNA methylation reflects cord blood C-reactive protein levels but not maternal levels: a longitudinal study and meta-analysis

Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation

Maternal Hypertensive Pregnancy Disorders and Mental Disorders in Children

Persistently High Levels of Maternal Antenatal Inflammation Are Associated With and Mediate the Effect of Prenatal Environmental Adversities on Neurodevelopmental Delay in the Offspring

Plasma pentraxin 3 is higher in early ovarian hyperstimulation syndrome than in uncomplicated in vitro fertilization cycle of high-risk women

Polygenic Prediction of the Risk of Perinatal Depressive Symptoms

Predisposition to superimposed preeclampsia in women with chronic hypertension: endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort

Saltatory Pattern of Fetal Heart Rate during Labor Is a Sign of Fetal Hypoxia

Kliniskt-kemisk avdelning vid Kuopio universitetssjukhus samt institutionen för klinisk kemi vid Kuopio universitet verksamheten under åren 1959-1995

Diet and urinary estrogen profile in various populations. A preliminary report