Hani El-Nezamy
Professor
Gut Health and Food Safety Research Laboratory (GHFS)
Institute of Public Health and Clinical Nutrition, School of Medicine, Faculty of Health Sciences
[email protected] | +358 40 591 5137
Research in GHFS laboratory has three focal areas:
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Modulation of gut health parameters by probiotics and bioactive components in food.
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Microbial therapy as an approach for management of liver diseases.
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Gut microbiota in health and diseases.
Research groups
Projects
Publications
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Alpha-aminobutyric Acid Ameliorates Diet-induced Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Progression in Mice via Enhancing AMPK/SIRT1 Pathway and Modulating the Gut-Liver Axis
Felicianna; Lo, Emily Kwun Kwan; Chen, Congjia; Ismaiah, Marsena Jasiel; Zhang, Fangfei; Leung, Hoi Kit Matthew; El-Nezami, Hani. 2025. Journal of nutritional biochemistry. 140: A1 Journal article (refereed), original research -
Alpha-aminobutyric acid administration suppressed visceral obesity and modulated hepatic oxidized PUFA metabolism via gut microbiota modulation
Ismaiah, Marsena Jasiel; Kwan Lo, Emily Kwun; Chen, Congjia; Shing-Jie Tsui, Jacob; Johnson-Hill, Winifred Audrey; Felicianna; Zhang, Fangfei; Matthew Leung, Hoi Kit; Oger, Camille; Durand, Thierry; Chung-Yung Lee, Jetty; El-Nezami, Hani. 2025. Free radical biology and medicine. 232: 86-96 A1 Journal article (refereed), original research -
Deoxynivalenol modulated mucin expression and proinflammatory cytokine production, affecting susceptibility to enteroinvasive <i>Escherichia coli</i> infection in intestinal epithelial cells
Wan, Murphy Lam Yim; Co, Vanessa Anna; Turner, Paul C; Nagendra, Shah P; El‐Nezami, Hani. 2025. Journal of food science. 90: A1 Journal article (refereed), original research -
Probiotics Mixture, Prohep: a Potential Adjuvant for Low-Dose Sorafenib in Metabolic Dysfunction–Associated Steatotic Liver Disease–Associated Hepatocellular Carcinoma Suppression Through Modulating Gut Microbiota
Zhang, Fangfei; Lo, Emily Kwun Kwan; Chen, Congjia; Lee, Jetty Chung-Yung; Felicianna; Ismaiah, Marsena Jasiel; Leung, Hoi Kit Matthew; Tsang, Dorothy Hin Lam; El-Nezami, Hani. 2025. Probiotics and antimicrobial proteins. [Published: 23 May 2025]: 1-17 A1 Journal article (refereed), original research -
The effect of aldafermin expressing-Escherichia coli Nissle 1917 along with dietary change on visceral adipose tissue in MASLD mouse model
Iannone, Valeria; Vaittinen, Maija; Gómez-Gallego, Carlos; Mikkonen, Santtu; Lok, Johnson; D’Auria, Giuseppe; Vazquez-Uribe, Ruben; Tikkanen, Ida; Sommer, Morten Otto Alexander; El-Nezami, Hani; Kolehmainen, Marjukka. 2025. International journal of obesity. [Published: 10 April 2025]: 1-11 A1 Journal article (refereed), original research -
Bioavailability and interactions of schisandrin B with 5-fluorouracil in a xenograft mouse model of colorectal cancer
Lee, Pui-Kei; Co, Vanessa Anna; Yang, Yang; Wan, Murphy Lam Yim; El-Nezami, Hani; Zhao, Danyue. 2024. Food chemistry. 2025; 463: A1 Journal article (refereed), original research -
Engineered Escherichia coli Nissle 1917 Expressing IGF1 and FGF19 Reduce Liver Fat Accumulation and Restore Microbial Equilibrium in a Metabolic Dysfunction-Associated Steatotic Liver Disease Mice Model
Lok, Johnson; Iannone, Valeria; Gómez-Gallego, Carlos; Vazquez-Uribe, Ruben; Sommer, Morten Otto Alexander; Kolehmainen, Marjukka; El-Nezami, Hani. 2024. Proceedings abstract -
Low-dose Valine Attenuates Diet-induced Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) in Mice by Enhancing Leptin Sensitivity and Modulating the Gut Microbiome
Felicianna; Kwan Lo, Emily Kwun; Chen, Congjia; Ismaiah, Marsena Jasiel; Zhang, Fangfei; Matthew Leung, Hoi Kit; El-Nezami, Hani. 2024. Molecular metabolism. 90: A1 Journal article (refereed), original research -
MRGPRB2/X2 and the analogous effects of its agonist and antagonist in DSS-induced colitis in mice
Duraisamy, Karthi; Kumar, Mukesh; Nawabjan, Abdullah; Lo, Emily Kwun Kwan; hui Lin, Ming; Lefranc, Benjamin; Bonnafé, Elsa; Treilhou, Michel; El-Nezami, Hani; Leprince, Jérôme; Chow, Billy KC. 2024. Biomedicine and pharmacotherapy. 174: A1 Journal article (refereed), original research -
Modulation of Gut Microbial Biomarkers and Metabolites in Cancer Management by Tea Compounds
Leung, Hoi Kit Matthew; Lo, Emily Kwun Kwan; Zhang, Fangfei; Felicianna; Ismaiah Marsena Jasiel; Chen, Congjia; El-Nezami, Hani. 2024. International journal of molecular sciences. 25: A2 Review article, Literature review, Systematic review