Ilkka Harvima
Professor
Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences
ilkka.harvima@uef.fi
Research groups
Publications
135/135 items-
Spectrum of malignant and premalignant skin lesions in 505 adult subjects at risk of skin cancers
Nevakivi, Reetta; Siiskonen, Hanna; Haimakainen, Salla; Harvima, Ilkka T. 2024. Bmc cancer. 24: . 338 -
Corticotropin‐releasing hormone receptor‐1 is increased in mast cells in psoriasis and actinic keratosis, but not markedly in keratinocyte skin carcinomas
Haimakainen, Salla; Harvima, Ilkka T.. 2023. Experimental dermatology. 32: 1794-1804 -
FoxP3-Positive Cells and Their Contacts with Mast Cells Are Highly Increased in Basal Cell Carcinoma
Kaukinen, Antti P; Harvima, Rauno J; Harvima, Ilkka T. 2023. International archives of allergy and immunology. 2024; 185: 167-169 -
Gynecomastia in a Young Male Caused by lsotretinoin : A Case Report
Harvima, Rauno J.; Laaksonen, David E.; Lonka, Minna; Harvima, Ilkka T.. 2023. Journal of clinical case reports. 13: -
Patients with a history of atopy have fewer cutaneous melanomas than those without atopy: a cross-sectional study in 496 patients at risk of skin cancers
Komulainen, Jenni; Siiskonen, Hanna; Haimakainen, Salla; Kanasuo, Emilia; Harvima, Rauno J.; Harvima, Ilkka T.. 2023. Melanoma research. 33: 218-229 -
The prognostic and predictive role of tumor-infiltrating lymphocytes (FoxP3 + and CD8 +) and tumor-associated macrophages in early HER2 + breast cancer
Jääskeläinen, Minna M; Tiainen, Satu; Siiskonen, Hanna; Ahtiainen, Maarit; Kuopio, Teijo; Rönkä, Aino; Kettunen, Tiia; Hämäläinen, Kirsi; Rilla, Kirsi; Harvima, Ilkka; Mannermaa, Arto; Auvinen, Päivi. 2023. Breast cancer research and treatment. 201: 183-192 -
Vaikean penisilliiniallergian epätavallinen kehittyminen
Harvima, Rauno; Harvima, Ilkka. 2023. Lääkärilehti. 78: 721-724 -
Case: Unexpected development of severe penicillin allergy and review of literature
Harvima, Rauno J; Harvima, Ilkka T. 2022. Clinical case reports. 10: . e05248 -
Erythema Multiforme in a Patient with Reactive Arthritis: Usefulness of Lymphocyte Stimulation Test for Detection of Sulfasalazine Hypersensitivity in a Case Report
Harvima, Rauno; Harvima, Ilkka. 2022. Journal of clinical case reports. 12: 1-3 -
Malignant and in situ subtypes of melanoma are associated with basal and squamous cell carcinoma and its precancerous lesions
Suhonen, Ville; Siiskonen, Hanna; Suni, Maunu; Rummukainen, Jaana; Mannermaa, Arto; Harvima, Ilkka T.. 2022. European journal of dermatology. 32: 187-194 -
Mast cell chymase is in contact with melanoma cells in vivo and it detaches melanoma cells from the substratum in vitro
Siiskonen, Hanna; Harvima, Ilkka T.. 2022. Translational cancer research. 11: 4315-4325 -
Pinoresinol stimulates keratinocyte proliferation and downregulates TNF‐α secretion in peripheral blood mononuclear cells: An experimental in vitro study
Haapakorva, Elias; Raunio, Hannu; von Wright, Atte; Harvima, Ilkka. 2022. Health science reports. 2023; 6: -
Regular use of vitamin D supplement is associated with fewer melanoma cases compared to non-use: a cross-sectional study in 498 adult subjects at risk of skin cancers
Kanasuo, Emilia; Siiskonen, Hanna; Haimakainen, Salla; Komulainen, Jenni; Harvima, Ilkka T. 2022. Melanoma research. 2023; 33: 126-135 -
Sequential Increase in Complement Factor I, iC3b, and Cells Expressing CD11b or CD14 in Cutaneous Vasculitis
Rahkola, Dina; Lipitsä, Tiina; Siiskonen, Hanna; Naukkarinen, Anita; Harvima, Ilkka T. 2022. Analytical cellular pathology. 2022: -
Survival from cutaneous malignant melanoma is improving, but is it because of a trend in decreasing melanoma thickness or the advent of new ‘revolutionary’ therapeutics?
Harvima, Ilkka T.; Harvima, Rauno J.. 2022. British journal of dermatology. 187: 6-7 -
The Use of Lymphocyte Stimulation Test in Severe Nabumetone-Induced Stevens-Johnson Syndrome: A Case Report
Harvima, Rauno J; Harvima, Ilkka T; Poso, Antti; Rysä , Jaana; Ojala, Raimo . 2022. Journal of clinical case reports. 12: -
Association of Elevated Serum Tryptase with Cutaneous Photodamage and Skin Cancers
Komulainen, Jenni; Siiskonen, Hanna; Harvima, Ilkka T. 2021. International archives of allergy and immunology. 182: 1135-1142 -
Erythrasma Capitis and Diffuse Hair Loss with Patches and Eczema-a Rare but Underdiagnozed Entity?
Harvima, Rauno; Harvima, Ilkka. 2021. Annals of case reports. 6: -
High regional mortality due to malignant melanoma in Eastern Finland may be explained by the increase in aggressive melanoma types
Suhonen, Ville; Rummukainen, Jaana; Siiskonen, Hanna; Mannermaa, Arto; Harvima, Ilkka T. 2021. Bmc cancer. 21: 1155 -
Mast Cells in Human Cutaneous Neurofibromas: Density, Subtypes, and Association with Clinical Features in Neurofibromatosis 1
Kallionpää, Roope A.; Ahramo, Kaisa; Martikkala, Eija; Fazeli, Elnaz; Haapaniemi, Pekka; Rokka, Anne; Leivo, Ilmo; Harvima, Ilkka T.; Peltonen, Juha; Peltonen, Sirkku. 2021. Dermatology. 2022; 238: 329-339 -
Sisters with Generalized Pustular Psoriasis Successful Treatment with Biologics
Harvima, Rauno; Harvima, Ilkka. 2021. Journal of case reports in medicine. 10: 21-23 -
Akuutti urtikaria
Harvima, Ilkka; Ackermann, Leena. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes(toim.) , 2020. Allergiset sairaudet ja astma. s. 114. Kustannus Oy Duodecim -
Allergiseen reaktioon osallistuvat solut
Virtanen, Tuomas; Savolainen, Johannes; Harvima, Ilkka. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes(toim.) , 2020. Allergiset sairaudet ja astma. s. 37-43. Kustannus Oy Duodecim -
Allergiset sairaudet ja astma
Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes. 2020. . . Kustannus Oy Duodecim -
Angioödeemat
Harvima, Ilkka; Ackermann, Leena. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes(toim.) , 2020. Allergiset sairaudet ja astma. s. 118-120. Kustannus Oy Duodecim -
Ihotestit allergiadiagnostiikassa
Harvima, Ilkka. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes(toim.) , 2020. Allergiset sairaudet ja astma. s. 68. Kustannus Oy Duodecim -
Kontaktiallergia
Harvima, Ilkka. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes(toim.) , 2020. Allergiset sairaudet ja astma. s. 48-50. Kustannus Oy Duodecim -
Kosketusallergeenit
Harvima, Ilkka. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes(toim.) , 2020. Allergiset sairaudet ja astma. s. 34-35. Kustannus Oy Duodecim -
Krooninen indusoituva urtikaria
Harvima, Ilkka; Ackermann, Leena. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes(toim.) , 2020. Allergiset sairaudet ja astma. s. 116-118. Kustannus Oy Duodecim -
Krooninen spontaani urtikaria
Harvima, Ilkka; Ackermann, Leena. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes(toim.) , 2020. Allergiset sairaudet ja astma. s. 114-116. Kustannus Oy Duodecim -
Kroonisen urtikarian hoito
Harvima, Ilkka; Ackermann, Leena. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes(toim.) , 2020. Allergiset sairaudet ja astma. s. 121-124. Kustannus Oy Duodecim -
Successful treatment of iatrogenically developed cutaneous calcification by tetracycline in Labrador retriever
Harvima, RJ; Halonen, P; Pirinen, E; Kolehmainen-Harvima, KS; Harvima, IT. 2020. Animal husbandry, dairy and veterinary science. 4: 1-4 -
Urtikaria ja sen ilmeneminen
Harvima, Ilkka; Ackermann, Leena. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes(toim.) , 2020. Allergiset sairaudet ja astma. s. 112-113. Kustannus Oy Duodecim -
Urtikariaa muistuttavia ihoraktioita aiheuttavat taudit
Harvima, Ilkka; Ackermann, Leena. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes(toim.) , 2020. Allergiset sairaudet ja astma. s. 120-121. Kustannus Oy Duodecim -
Mast Cells Are a Marked Source for Complement C3 Products That Associate with Increased CD11b-Positive Cells in Keratinocyte Skin Carcinomas
Rahkola, Dina; Laitala, Joel; Siiskonen, Hanna; Pelkonen, Jukka; Harvima, Ilkka T. 2019. Cancer investigation. 37: 73-84 -
Mast Cells and Sensory Nerves Contribute to Neurogenic Inflammation and Pruritus in Chronic Skin Inflammation
Siiskonen, Hanna; Harvima, Ilkka. 2019. Frontiers in cellular neuroscience. 13: 422 -
Mast cell chymase degrades fibrinogen and fibrin
Lipitsä, T; Siiskonen, H; Naukkarinen, A; Harvima, IT. 2019. British journal of dermatology. 181: 296-303 -
Accuracy and reliability of a hand-held in vivo skin indentation device to assess skin elasticity
Virén, T; Iivarinen, JT; Sarin, JK; Harvima, I; Mayrovitz, HN. 2018. International journal of cosmetic science. 40: 134-140 -
Increase in FoxP3-positive Cells and Their Contacts with Mast Cells in Köbner-negative Patients with Psoriasis after Tape-stripping
Suttle, Mireille-Maria; Ritanen, Riikka-Liisa; Harvima, Ilkka T. 2018. Acta dermato-venereologica. 2019; 99: 103-104 -
Mast cell-neural interactions contribute to pain and itch
Gupta, Kalpna; Harvima, Ilkka T. 2018. Immunological reviews. 282: 168-187 -
CD40 Ligand Is Increased in Mast Cells in Psoriasis and Actinic Keratosis but Less So in Epithelial Skin Carcinomas
Haimakainen S, Kaukinen AP, Suttle M-M, Pelkonen J, Harvima IT. 2017. Cancer investigation. 35: 143-151 -
Immunoreactivity to CYP24A1, but not vitamin D receptor, is increased in mast cells of keratinocyte skin cancers
Kaukinen Antti, Siiskonen Harri, Pelkonen Jukka, Harvima Ilkka T. 2017. European journal of dermatology. 27: 590-598 -
Melanooman riskitekijät
Siiskonen Hanna, Harvima Ilkka. 2017. Lääkärilehti. 72: 1563-1569 -
Complement C3 is expressed by mast cells in cutaneous vasculitis and is degraded by chymase
Lipitsä T, Naukkarinen A, Laitala J, Harvima IT. 2016. Archives of dermatological research. [first online 27 July 2017]: 1-10 -
Immediate Wheal Reactivity to Autologous Sweat in Atopic Dermatitis Is Associated with Clinical Severity, Serum Total and Specific IgE and Sweat Tryptase Activity
Ilves T, Virolainen A, Harvima IT. 2016. International archives of allergy and immunology. 170: 84-91 -
Increased mitogen-stimulated lymphocyte proliferation is associated with the clinical response in major depressive disorder in women: A follow-up study
Elomaa Antti-Pekka, Viinamäki Heimo, Harvima Ilkka T, Koivumaa-Honkanen, Honkalampi Kirsi, Valkonen-Korhonen Minna, Lehti Soili M. 2016. Psychiatry research. 239: 220-221 -
Kansallinen ihosyöpäohjelma tarvitaan nyt
Harvima Ilkka, Kähäri Veli-Matti, Ranki Annamari, Snellman Erna, Tasanen-Määttä Kaisa. 2016. Lääkärilehti. 71: 462-463 -
Epidermal Expression of Filaggrin/Profilaggrin Is Decreased in Atopic Dermatitis: Reverse Association With Mast Cell Tryptase and IL-6 but Not With Clinical Severity
Ilves Tiina, Tiitu Virpi, Suttle Mireille-Maria, Saarinen Jari Vilho, Harvima Ilkka Tapani. 2015. Dermatitis. 26: 260-267 -
Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma
Siiskonen Hanna, Poukka Mari, Bykachev Andrey, Tyynelä-Korhonen Kristiina, Sironen Reijo, Pasonen-Seppänen Sanna, Harvima Ilkka T. 2015. Melanoma research. [epub ahead of print 27 July 2015]: - -
Mast cell chymase in experimentally induced psoriasis
Suttle Mireille-Maria, Harvima Ilkka T. 2015. Journal of dermatology. 2016; 43: 693-696 -
Mast cell tryptase and chymase in the progress of cutaneous vasculitis
Lipitsä Tiina, Naukkarinen Anita, Harvima Ilkka T. 2015. Archives of dermatological research. 307: 917-924 -
Mast cells express CYP27A1 and CYP27B1 in epithelial skin cancers and psoriasis
Kaukinen Antti, Pelkoonen Jukka, Harvima Ilkka T. 2015. European journal of dermatology. [epub ahead of print]: - -
Decrease in Chymase Activity is Associated with Increase in IL-6 Expression in Mast Cells in Atopic Dermatitis
Ilves T, Harvima I. 2014. Acta dermato-venereologica. Epub: -- -
Experimentally Induced Psoriatic Lesions Associate with Rapid but Transient Decrease in Interleukin-33 Immunostaining in Epidermis
Suttle MM, Enoksson M, Zoltowska A, Chatterjee M, Nilsson G, Harvima IT. 2014. Acta dermato-venereologica. 95: 536-541 -
Increased Numbers of Tryptase-Positive Mast Cells in the Healthy and Sun-Protected Skin of Tobacco Smokers
Kaukinen A, Fitzgibbon A, Oikarinen A, Hinkkanen L, Viinikanoja M, Harvima IT. 2014. Dermatology. 229: 353-358 -
Molecular targets on mast cells and basophils for novel therapies
Harvima Ilkka T, Levi-Schaffer Francesca, Draber Petr, Friedman Sheli, Polakovicova Iva, Gibbs Bernhard F, Blank Ulrich, Nilsson Gunnar, Maurer Marcus. 2014. Journal of allergy and clinical immunology. 134: 530-544 -
Reduced serum adiponectin levels in alexithymia
Honkalampi K, Viinamäki H, Niskanen L, Koivumaa-Honkanen H, Valkonen-Korhonen M, Elomaa AP, Harvima I, Herzig KH, Lehto SM. 2014. Neuroimmunomodulation. 21: 234-239 -
Anti-apoptotic bfl-1 is the major effector in activation-induced human mast cell survival
Ekoff M, Lyberg K, Krajewska M, Arvidsson M, Rak S, Reed JC, Harvima I, Nilsson G. 2012. PLoS ONE. 7: e39117; 1-7 -
Elevated levels of serum IL-5 are associated with an increased likelihood of major depressive disorder
Elomaa A-P, Niskanen L, Herzig K-H, Viinamäki H, Hintikka J, Koivumaa-Honkanen H, Honkalampi K, Valkonen-Korhonen M, Harvima I, Lehto SM. 2012. Bmc psychiatry. 12: 2 -
Experimentally induced psoriatic lesion associates with interleukin (IL)-6 in mast cells and appearance of dermal cells expressing IL-33 and IL-6 receptor
Suttle, M.-M; Nilsson, G; Snellman, E; Harvima IT. 2012. Clinical and experimental immunology. 169: 311-319 -
Glukokortikoidien yhteys masennuksen syntyyn ja oirekuvaan
Viinamäki, Heimo; Lehto, Soili M.; Palvimo, Jorma J., Harvima, Ilkka; Valkonen-Korhonen, Minna; Koivumaa-Honkanen, Heli; Hintikka, Jukka; Honkalampi, Kirsi ja Niskanen Leo. 2012. Duodecim. 128: 1022-1029 -
OX40 ligand and OX40 are increased in atopic dermatitis lesions but do not correlate with clinical severity
Ilves T, Harvima I. 2012. Journal of the european academy of dermatology and venereology. 2012: 1-9 -
Stress, the neuroendocrine system and mast cells: current understanding of their role in psoriasis
Harvima I, Nilsson G. 2012. Expert review of clinical immunology. 8: 235-241 -
Mast cell chymase is present in uterine cervical carcinoma and it detaches viable and growing cervical squamous carcinoma cells from substratum in vitro
Diaconu Nicolae-Costin, Rummukainen Jaana, Naukkarinen Anita, Mättö Mikko, Harvima Rauno J, Pelkonen Jukka, Harvima Ilkka T.. 2011. Archives of dermatological research. 303: 499-512 -
Mast cells as regulators of skin inflammation and immunity
Harvima IT, Nilsson G. 2011. Acta dermato-venereologica. 91: 644-650 -
Increased mast cell expression of PAR-2 in skin inflammatory diseases and release of IL-8 upon PAR-2 activation
da Silva Carvalho RF, Nilsson G & Harvima IT. 2010. Experimental dermatology. 19: 117-122 -
Role of mast cells and sensory nerves in skin inflammation
I.T. Harvima, G. Nilsson, A. Naukkarinen. 2010. GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA. 145: 195-204 -
The BH3-Mimetic ABT-737 Induces Mast Cell Apoptosis In Vitro and In Vivo: Potential for Therapeutics
Mats Karlberg, Maria Ekoff, David C.S. Huang, Paula Mustonen, Ilkka T. Harvima & Gunnar Nilsson. 2010. Journal of immunology. 185: 2555-2562 -
Human mast cells adhere to and migrate on epithelial and vascular basement membrane laminins LM-332 and LM-511 via alpha(3)beta(1) integrin
Sime W, Lunderius-Andersson C, Enoksson M, Rousselle P, Tryggvason K, Nilsson G, Harvima I, Patarroyo M. 2009. Journal of immunology. 183: 4657-4665 -
Cervical squamous carcinoma cells are resistant to the combined action of tumor necrosis factor-alpha and histamine whereas normal keratinocytes undergo cytolysis
Diaconu N-C, Rummukainen J, Mättö M, Naukkarinen A, Harvima RJ, Pelkonen J, Harvima IT. 2008. Bmc cancer. 8: [15, art. 46] -
Induction of matrix metalloproteinase-9 in keratinocytes by histamine
Harvima IT. 2008. Journal of investigative dermatology. 128: 2748-50 -
Is there a role for mast cells in psoriasis?
Harvima IT, Nilsson G, Suttle MM, Naukkarinen A. 2008. Archives of dermatological research. 300: 461-78 -
Expression of 15-lipoxygenase type-1 in human mast cells
Gulliksson M, Brunnström A, Johannesson M, Backman L, Nilsson G, Harvima I, Dahlén B, Kumlin M, Claesson HE. 2007. Biochimica et biophysica acta: international journal of biochemistry and biophysics. 1771: 1156-1165 -
Histamine, but not leukotriene C4, is an essential mediator in cold urticaria wheals
Nuutinen P, Harvima IT, Ackermann L. 2007. Acta dermato-venereologica. 87: 9-13 -
Increase in CD30 ligand/CD153 and TNF-alpha expressing mast cells in basal cell carcinoma
Diaconu NC, Kaminska R, Naukkarinen A, Harvima RJ, Nilsson G, Harvima IT. 2007. Cancer immunology immunotherapy. 56: 1407-1415 -
Juvenile-onset neuronal ceroid lipofuscinosis with infantile CNL1 mutation and palmitoyl-protein thioesterase deficiency
Kälviäinen R, Eriksson K, Losekoot M, Sorri I, Harvima I, Santavuori P, Järvelä I, Autti T, Vanninen R, Salmenperä T, van Diggelen OP. 2007. European journal of neurology. 14: 369-372 -
The increase in tryptase- and chymase-positive mast cells is associated with partial inactivation of chymase and increase in protease inhibitors in basal cell carcinoma
Diacony NC, Kaminska R, Naukkarinen A, Harvima R, Harvima I. 2007. Journal of the european academy of dermatology and venereology. 21: 908-915 -
Hyaluronic acid inhibits the adherence and growth of monolayer keratinocytes but does not affect the growth of keratinocyte epithelium
Harvima IT, Heikura H, Hyttinen M, Naukkarinen A. 2006. Archives of dermatological research. 298: 207-219 -
Mast cell CD30 ligand is upregulated in cutaneus inflammation and mediates degranulation-independent chemokine secretion
Fischer M, Harvima IT, Carvalho RFS, Möller C, Naukkarinen A, Enblad G, Nilsson G. 2006. Journal of clinical investigation. 116: 2748-2756 -
CC chemokine receptors CCR1 and CCR4 are expressed on airway mast cells in allergic asthma
Amin K, Janson C, Harvima I, Venge P, Nilsson G. 2005. Journal of allergy and clinical immunology. 116: 1383-386 -
Effect of temporin A modifications on its cytotoxicity and antimicrobial activity
Mäntylä T, Sirola H, Kansanen E, Korjamo T, Lankinen H, Lappalainen K, Välimaa AL, Harvima I, Närvänen A. 2005. Apmis. 113: 497-505 -
Efficacy of dietary hempseed oil in patients with atopic dermatitis
Callaway J, Schwab U, Harvima I, Halonen P, Mykkänen O, Hyvönen P, Järvinen T. 2005. Journal of dermatological treatment. 16: 87-94 -
Mast cell tryptase and chymase in chronic leg ulcers: chymase is potentially destructive to epithelium and is contolled by proteinase inhibitors
Huttunen M, Harvima IT. 2005. British journal of dermatology. 152: 1149-1160 -
Study of innervation, sensory neuropeptides, and serotonin in murine contact allergic skin
El-Nour H, Lundeberg L, Boman A, Beck O, Harvima IT, Theodorsson E, Nordlind K. 2005. Immunopharmacology and immunotoxicology. 27: 67-76 -
Heparin modulates the growth and adherence and augments the gowth-inhibitory action of TNF-alpha on cultured human keratinocytes
Harvima IT, Lappalainen K, Hirvonen MR, Matto M, Kivinen PK, Hyttinen M, Pelkonen J, Naukkarinen A. 2004. Journal of cellular biochemistry. 92: 372-386 -
The production of collagen and the activity of mast-cell chymase increase in human skin after irridation therapy
Riekki R, Harvima IT, Jukkola A, Risteli J, Oikarinen A. 2004. Experimental dermatology. 13: 364-71 -
A closed unventilated chamber for the measurement of transepidermal water loss
Nuutinen J, Alanen E, Autio P, Lahtinen M-R, Harvima I, Lahtinen T. 2003. Skin research and technology. 9: 85-89 -
Bergeyella zoohelcum septicaemia of a patient suffering from severe skin infection
Kivinen PK, Lahtinen M-R, Ruotsalainen E, Harvima IT, Katila M-L. 2003. Acta dermato-venereologica -
Mast cell survival and apoptosis in organ-cultured human skin
Kivinen PK, Nilsson G, Naukkarinen A, Harvima IT. 2003. Experimental dermatology. 12: 53-60 -
Mast cells, nerves and neuropeptides in atopic dermatitis and nummular eczema
Järvikallio A, Harvima IT, Naukkarinen A. 2003. Archives of dermatological research. 295: 2-7 -
Retinoic acid inhibits in vitro development of mast cells but has no marked effect on mature human skin tryptase- and chymase-positive mast cells
Hjertson M, Kivinen PK, Dimberg L, Nilsson K, Harvima IT, Nilsson G. 2003. Journal of investigative dermatology. 120: 239-245 -
Water loss through the lip, nail, eyelid skin, scalp skin, and axillary skin measured with a closed-chamber evaporation principle
Nuutinen J, Harvima I, Lahtinen M-R, Lahtinen T. 2003. British journal of dermatology. 148: 839-841 -
Transient production of stem cell factor in dermal cells but increasing expression of Kit receptor in mast cells during normal wound healing
Huttunen M, Naukkarinen A, Horsmanheimo M, Harvima IT. 2002. Archives of dermatological research. 294: 324-330 -
Inhibition of keratinocyte growth in cell culture and whole skin culture by mast cell mediators
Huttunen M, Hyttinen M, Nilsson G, Butterfield JH, Horsmanheimo M, Harvima IT. 2001. Experimental dermatology. 10: 184-192 -
Interleukin-4-posituve mast cells are highly associated with the extent of immediate allergic wheal reaction in the skin
Saarinen JV, Harvima RJ, Horsmanheimo M, Harvima IT, Naukkarinen A. 2001. Allergy. 56: 58-64 -
Kroonisten säärihaavojen hoito edellyttää yhteistyötä ja tehokkaita menetelmiä
Harvima I. 2001. NOVARTIS NEWS. 1: 32-34 -
Mast cells express functional CD30 ligand and are the predominant CD30L-positive cells in Hodgkin's disease
Molin D, Fischer M, Xiang Z, Larsson U, Harvima I, Venge P, Nilsson K, Sundstrom C, Enblad G, Nilsson G. 2001. British journal of haematology. 114: 616-623 -
Modulation of the immediate allergic wheal reaction in the skin by drugs inhibiting the effects on leukotriene C4 and prostaglandin D2
Saarinen JV, Harvima RJ, Horsmanheimo M, Harvima IT. 2001. European journal of clinical pharmacology. 57: 1-4 -
Release of soluble tryptase but only minor amounts of chymase activity from cutaneous mast cells
Kivinen PK, Kaminska R, Naukkarinen A, Harvima RJ, Horsmanheimo M, Harvima IT. 2001. Experimental dermatology. 10: 246-255 -
The release of histamine is associated with the inactivation of mast cell chymase during immediate allergic wheal reaction in the skin
Saarinen JV, Harvima RJ, Naukkarinen A, Horsmanheimo M, Harvima IT. 2001. Clinical and experimental allergy. 31: 593-601 -
Alterations in mast cells showing tryptase and chymase activity in epithelializatingand chronic wounds
Huttunen M, Aalto M-L, Harvima RJ, Horsmanheimo M, Harvima IT. 2000. Experimental dermatology. 9: 258-265 -
Bee venom induces high histamine or high leukotriene C4 release in skin of sensitized beekeepers
Annila I, Saarinen JV, Nieminen MM, Moilanen E, Hahtola P, Harvima IT. 2000. Journal of investigational allergology and clinical immunology. 10: 223-228 -
Histamine and LTC4 in stinging nettle-induced urticaria
Taskila K, Saarinen JV, Harvima IT, Harvima RJ. 2000. Allergy. 55: 679-680 -
Kun tutkija yrittää julkaista tutkimuksensa... Kokeneiden tutkijoiden näkökulmia käsikirjoituksen tarjoamisesta tieteelliseen lehteen
Harvima R, Harvima I. 2000. LÄÄKÄRISANOMAT. : 31 -
Lääkkeiden käytön ja ihoreaktioiden kuvauksen sekä kirjaamisen tärkeys myöhemmälle diagnostiikalle
Harvima R, Laukkanen A, Harvima I, Mattila R, Hollmén A. 2000. Lääkärilehti. 55: 2195-2196 -
Release of histamine and leukotriene C4 in immendiate allergic wheal reaction as measured with microdialysis techinique
Saarinen JV, Harvima RJ, Naukkarinen A, Horsmanheimo M, Harvima IT. 2000. Archives of dermatological research. 292: 333-340 -
The chemokine receptor CXCR4 is expressed within the mast cell lineage and its ligand stromal cell-derived factor-1alfa acts as a mast cell chemotaxin
Juremalm M, Hjertson M, Olsson N, Harvima I, Nilsson K, Nilsson G. 2000. European journal of immunology. 30: 3614-3622 -
Cultured allogeneic skin cells are effective in the treatment of chronic diabetic leg and foot ulcers
Harvima IT, Virnes S, Kauppinen L, Huttunen M, Kivinen P, Niskanen L, Horsmanheimo M. 1999. Acta dermato-venereologica. 79: 217-220 -
Decreased chymase activity is associated with increased levels of protease inhibitors in mast cells of psoriatic lesions
Harvima IT, Haapanen L, Ackermann L, Naukkarinen A, Harvima RJ, Horsmanheimo M. 1999. Acta dermato-venereologica. 79: 98-104 -
Focal dermal-epidermal separation and fibronectin cleavage in basement membrane by human mast cell tryptase
Kaminska R, Helisalmi P, Harvima RJ, Naukkarinen A, Horsmanheimo M, Harvima IT. 1999. Journal of investigative dermatology. 113: 567-573 -
Identification and characterization of multiple forms of tryptase from human mast cells
Harvima RJ, Harvima IT, Dull D, Dunder UK, Schwartz LB. 1999. Archives of dermatological research. 291: 73-80 -
Mast cells in developing subepidermal bullous diseases: emphasis on tryptase, chymase and protease inhibitors
Kaminska R, Naukkarinen A, Glinski W, Horsmanheimo M, Harvima IT. 1999. Acta dermato-venereologica. 79: 351-355 -
Mast cells in psoriatic skin are strongly positive for interferon-gamma
Ackermann L, Harvima IT, Pelkonen J, Ritamäki-Salo V, Naukkarinen A, Harvima RJ, Horsmanheimo M. 1999. British journal of dermatology. 140: 624-633 -
Papillary hypertrophy of the upper tarsal conjunctiva during contact lens wear: a 4-month study with ethyl-6-O-decanoyl-glucoside
Vaahtoranta-Lehtonen HH, Lehtonen OP, Harvima I, Peltola O, Nikoskelainen E. 1999. CLAO JOURNAL. 25: 105-108 -
Pyoderma gangraenosumin paikallishoito kromoglikaattiliuoksella
Harvima RJ, Hollmén A, Mattila R, Kaipiainen-Seppänen O, Harvima IT, Kaminska R, Laukkanen A, Räsänen L, Horsmanheimo M. 1999. Duodecim. 115: 2085-2090 -
Quantitative digital image analysis applied to demonstrate the stratified distribution of involucrin in organ cultured human skin
Kivinen PK, Hyttinen M, Harvima RJ, Naukkarinen A, Horsmanheimo M, Harvima IT. 1999. Archives of dermatological research. 291: 217-223 -
Suction blister formation in skin after acute and repeated mast cell degranulation
Kaminska R, Naukkarinen A, Horsmanheimo M, Harvima IT. 1999. Acta dermato-venereologica. 79: 191-194 -
Diabeetikon jalkahaavaumien uudet aktiivisemmat hoitomuodot
Harvima I. 1998. DIABETES JA LÄÄKÄRI. : 8-16 -
Mast cells of psoriatic and atopic dermatitis skin are positive for TNF-alpha and their degranulation is associated with expression of ICAM-1 in the epidermis
Ackermann L, Harvima IT. 1998. Archives of dermatological research. 290: 353-359 -
Staphylococcal enterotoxin B inhibits the production of interleukin-4 in a human mast-cell line HMC-1
Ackermann L, Pelkonen J, Harvima IT. 1998. Immunology. 94: 247-252 -
Quantitative analysis of tryptase and chymase containing mast cells in benign and malignant breast lesions
Kankkunen J-P, Harvima IT, Naukkarinen A. 1997. International journal of cancer. 72: 385-388 -
Quantitative analysis of tryptase- and chymase-containing mast cells in atopic dermatitis and nummular eczema
Järvikallio A, Naukkarinen A, Harvima IT, Aalto M-L, Horsmanheimo M. 1997. British journal of dermatology. 136: 871-877 -
Alterations in mast cell proteinases and protease inhibitors in the progress of cutaneous herpes zoster infection
Kaminska R, Harvima IT, Naukkarinen A, Nilsson G, Horsmanheimo M. 1996. Journal of pathology. 180: 434-440 -
Association of psychic stress with clinical severity and symptoms of psoriatic patients
Harvima RJ, Viinamäki H, Harvima IT, Naukkarinen A, Savolainen L, Aalto M-L, Horsmanheimo M. 1996. Acta dermato-venereologica. 76: 467-471 -
Histamine and leukotriene C4 release in cutaneous mosquito-bite reactions
Horsmanheimo L, Harvima IT, Harvima RJ, Brummer-Korvenkontio H, Francois G, Reunala T. 1996. Journal of allergy and clinical immunology. 98: 408-411 -
Histamine release in skin monitored with the mikrodialysis technique does not correlate with the weal size induced by cow allergen
Horsmanheimo L, Harvima IT, Harvima RJ, Ylönen J, Naukkarinen A, Horsmanheimo M. 1996. British journal of dermatology. 134: 94-100 -
Kun nuori nainen valittaa tukan lähtöä
Harvima R, Harvima I. 1996. Lääkärilehti. 51: 1799-1801 -
Neuropeptide- and capsaicin-induced histamine release in skin monitored with the microdialysis technique
Huttunen M, Harvima IT, Ackermann L, Harvima RJ, Naukkarinen A, Horsmanheimo M. 1996. Acta dermato-venereologica. 76: 205-209 -
Palovammojen hoito
Härmä M, Ruokonen E, Harvima I, Takala J. 1996. Duodecim. 112: 1455-1462 -
Quantitative histochemical analysis of mast cells and sensory nerves in psoriatic skin
Naukkarinen A, Järvikallio A, Lakkakorpi J, Harvima IT, Harvima RJ, Horsmanheimo M. 1996. Journal of pathology. 180: 200-205 -
Stem cell factor-dependent human cord blood derived mast cells express alpha- and beta-tryptase, heparin and chondroitin sulphate
Nilsson G, Blom T, Harvima I, Kusche-Gullberg M, Nilsson K, Hellman L. 1996. Immunology. 88: 308-314 -
Demonstration of tryptase in bovine cutaneous and tumor mast cells
Welle MM, Proske SM, Harvima IT, Schechter NM. 1995. Journal of histochemistry and cytochemistry. 43: 1139-1144 -
Skin tryptase: Features and expression in human dermatological disorders
Harvima IT, Harvima RJ, Naukkarinen A, Horsmanheimo M. Teoksessa: Caughey GH(toim.) , 1995. Mast Cell Proteases in Immunology and Biology. s. 25-46. Marcel Dekker -
Mast cell proteinases and cytokines in skin inflammation
Harvima IT, Horsmanheimo L, Naukkarinen A, Horsmanheimo M. 1994. Archives of dermatological research. 287: 61-67 -
Mast cells are one major source of interleukin-4 in atopic dermatitis
Horsmanheimo L, Harvima IT, Järvikallio A, Harvima RJ, Naukkarinen A, Horsmanheimo M. 1994. British journal of dermatology. 131: 348-353