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Ilkka Harvima

Ilkka Harvima

Professor

School of Medicine, Institute of Clinical Medicine

ilkka.harvima@uef.fi | +358 50 441 3620

0504413620
050 4413620
050 441 3620
+358 50 441 3620
+35850 441 3620
050 4413 620
+358 50 4413 620
+35850 4413 620
+358 50 4413620
+35850 4413620
+358504413620

Information Publications

Research groups

The Immune System in Skin Cancers 01.01.2022 -
North-Savo Skin Cancer Program (NoSCaP)

Publications

125 items

Case: Unexpected development of severe penicillin allergy and review of literature
Harvima, Rauno J; Harvima, Ilkka T. 2022. Clinical case reports. 10: A1 Journal article (refereed), original research
Erythema Multiforme in a Patient with Reactive Arthritis: Usefulness of Lymphocyte Stimulation Test for Detection of Sulfasalazine Hypersensitivity in a Case Report
Harvima, Rauno; Harvima, Ilkka. 2022. Journal of clinical case reports. 12: 1-3 A1 Journal article (refereed), original research
Malignant and in situ subtypes of melanoma are associated with basal and squamous cell carcinoma and its precancerous lesions
Suhonen, Ville; Siiskonen, Hanna; Suni, Maunu; Rummukainen, Jaana; Mannermaa, Arto; Harvima, Ilkka T.. 2022. European journal of dermatology. 32: 187-194 A1 Journal article (refereed), original research
Mast cell chymase is in contact with melanoma cells in vivo and it detaches melanoma cells from the substratum in vitro
Siiskonen, Hanna; Harvima, Ilkka T.. 2022. Translational cancer research. 11: 4315-4325 A1 Journal article (refereed), original research
Pinoresinol stimulates keratinocyte proliferation and downregulates TNF‐α secretion in peripheral blood mononuclear cells: An experimental in vitro study
Haapakorva, Elias; Raunio, Hannu; von Wright, Atte; Harvima, Ilkka. 2022. Health science reports. 2023; 6: A1 Journal article (refereed), original research
Regular use of vitamin D supplement is associated with fewer melanoma cases compared to non-use: a cross-sectional study in 498 adult subjects at risk of skin cancers
Kanasuo, Emilia; Siiskonen, Hanna; Haimakainen, Salla; Komulainen, Jenni; Harvima, Ilkka T. 2022. Melanoma research. 2023; 33: 126-135 A1 Journal article (refereed), original research
Sequential Increase in Complement Factor I, iC3b, and Cells Expressing CD11b or CD14 in Cutaneous Vasculitis
Rahkola, Dina; Lipitsä, Tiina; Siiskonen, Hanna; Naukkarinen, Anita; Harvima, Ilkka T. 2022. Analytical cellular pathology. 2022: A1 Journal article (refereed), original research
Survival from cutaneous malignant melanoma is improving, but is it because of a trend in decreasing melanoma thickness or the advent of new ‘revolutionary’ therapeutics?
Harvima, Ilkka T.; Harvima, Rauno J.. 2022. British journal of dermatology. 187: 6-7 B1 Non-refereed journal articles
The Use of Lymphocyte Stimulation Test in Severe Nabumetone-Induced Stevens-Johnson Syndrome: A Case Report
Harvima, Rauno J; Harvima, Ilkka T; Poso, Antti; Rysä , Jaana; Ojala, Raimo . 2022. Journal of clinical case reports. 12: A1 Journal article (refereed), original research
Association of Elevated Serum Tryptase with Cutaneous Photodamage and Skin Cancers
Komulainen, Jenni; Siiskonen, Hanna; Harvima, Ilkka T. 2021. International archives of allergy and immunology. 182: 1135-1142 A1 Journal article (refereed), original research
Erythrasma Capitis and Diffuse Hair Loss with Patches and Eczema-a Rare but Underdiagnozed Entity?
Harvima, Rauno; Harvima, Ilkka. 2021. Annals of case reports. 6: B1 Non-refereed journal articles
High regional mortality due to malignant melanoma in Eastern Finland may be explained by the increase in aggressive melanoma types
Suhonen, Ville; Rummukainen, Jaana; Siiskonen, Hanna; Mannermaa, Arto; Harvima, Ilkka T. 2021. Bmc cancer. 21: 1155 A1 Journal article (refereed), original research
Mast Cells in Human Cutaneous Neurofibromas: Density, Subtypes, and Association with Clinical Features in Neurofibromatosis 1
Kallionpää, Roope A.; Ahramo, Kaisa; Martikkala, Eija; Fazeli, Elnaz; Haapaniemi, Pekka; Rokka, Anne; Leivo, Ilmo; Harvima, Ilkka T.; Peltonen, Juha; Peltonen, Sirkku. 2021. Dermatology. 2022; 238: 329-339 A1 Journal article (refereed), original research
Sisters with Generalized Pustular Psoriasis Successful Treatment with Biologics
Harvima, Rauno; Harvima, Ilkka. 2021. Journal of Case Reports in Medicine. 10: 21-23 B1 Non-refereed journal articles
Akuutti urtikaria
Harvima, Ilkka; Ackermann, Leena. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes, 2020. Allergiset sairaudet ja astma. s. 114. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor)
Allergiseen reaktioon osallistuvat solut
Virtanen, Tuomas; Savolainen, Johannes; Harvima, Ilkka. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes, 2020. Allergiset sairaudet ja astma. s. 37-43. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor)
Allergiset sairaudet ja astma
Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes. 2020. . . Kustannus Oy Duodecim D6 Edited professional book
Angioödeemat
Harvima, Ilkka; Ackermann, Leena. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes, 2020. Allergiset sairaudet ja astma. s. 118-120. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor)
Ihotestit allergiadiagnostiikassa
Harvima, Ilkka. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes, 2020. Allergiset sairaudet ja astma. s. 68. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor)
Kontaktiallergia
Harvima, Ilkka. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes, 2020. Allergiset sairaudet ja astma. s. 48-50. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor)
Kosketusallergeenit
Harvima, Ilkka. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes, 2020. Allergiset sairaudet ja astma. s. 34-35. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor)
Krooninen indusoituva urtikaria
Harvima, Ilkka; Ackermann, Leena. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes, 2020. Allergiset sairaudet ja astma. s. 116-118. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor)
Krooninen spontaani urtikaria
Harvima, Ilkka; Ackermann, Leena. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes, 2020. Allergiset sairaudet ja astma. s. 114-116. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor)
Kroonisen urtikarian hoito
Harvima, Ilkka; Ackermann, Leena. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes, 2020. Allergiset sairaudet ja astma. s. 121-124. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor)
Successful treatment of iatrogenically developed cutaneous calcification by tetracycline in Labrador retriever
Harvima, RJ; Halonen, P; Pirinen, E; Kolehmainen-Harvima, KS; Harvima, IT. 2020. Animal husbandry, dairy and veterinary science. 4: 1-4 B1 Non-refereed journal articles
Urtikaria ja sen ilmeneminen
Harvima, Ilkka; Ackermann, Leena. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes, 2020. Allergiset sairaudet ja astma. s. 112-113. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor)
Urtikariaa muistuttavia ihoraktioita aiheuttavat taudit
Harvima, Ilkka; Ackermann, Leena. Teoksessa: Mäkelä, Mika; Harvima, Ilkka; Kauppi, Paula; Ralli, Pia; Savolainen, Johannes, 2020. Allergiset sairaudet ja astma. s. 120-121. Kustannus Oy Duodecim D2 Article in a professional book (incl. an introduction by the editor)
Mast Cells Are a Marked Source for Complement C3 Products That Associate with Increased CD11b-Positive Cells in Keratinocyte Skin Carcinomas
Rahkola, Dina; Laitala, Joel; Siiskonen, Hanna; Pelkonen, Jukka; Harvima, Ilkka T. 2019. Cancer investigation. 37: 73-84 A1 Journal article (refereed), original research
Mast Cells and Sensory Nerves Contribute to Neurogenic Inflammation and Pruritus in Chronic Skin Inflammation
Siiskonen, Hanna; Harvima, Ilkka. 2019. Frontiers in cellular neuroscience. 13: 422 A2 Review article, Literature review, Systematic review
Mast cell chymase degrades fibrinogen and fibrin
Lipitsä, T; Siiskonen, H; Naukkarinen, A; Harvima, IT. 2019. British journal of dermatology. 181: 296-303 A1 Journal article (refereed), original research
Accuracy and reliability of a hand-held in vivo skin indentation device to assess skin elasticity
Virén, T; Iivarinen, JT; Sarin, JK; Harvima, I; Mayrovitz, HN. 2018. International journal of cosmetic science. 40: 134-140 A1 Journal article (refereed), original research
Increase in FoxP3-positive Cells and Their Contacts with Mast Cells in Köbner-negative Patients with Psoriasis after Tape-stripping
Suttle, Mireille-Maria; Ritanen, Riikka-Liisa; Harvima, Ilkka T. 2018. Acta dermato-venereologica. 2019; 99: 103-104 A1 Journal article (refereed), original research
Mast cell-neural interactions contribute to pain and itch
Gupta, Kalpna; Harvima, Ilkka T. 2018. Immunological reviews. 282: 168-187 A2 Review article, Literature review, Systematic review
CD40 Ligand Is Increased in Mast Cells in Psoriasis and Actinic Keratosis but Less So in Epithelial Skin Carcinomas
Haimakainen S, Kaukinen AP, Suttle M-M, Pelkonen J, Harvima IT. 2017. Cancer investigation. 35: 143-151 A1 Journal article (refereed), original research
Immunoreactivity to CYP24A1, but not vitamin D receptor, is increased in mast cells of keratinocyte skin cancers
Kaukinen Antti, Siiskonen Harri, Pelkonen Jukka, Harvima Ilkka T. 2017. European journal of dermatology. 27: 590-598 A1 Journal article (refereed), original research
Melanooman riskitekijät
Siiskonen Hanna, Harvima Ilkka. 2017. Lääkärilehti. 72: 1563-1569 A2 Review article, Literature review, Systematic review
Complement C3 is expressed by mast cells in cutaneous vasculitis and is degraded by chymase
Lipitsä T, Naukkarinen A, Laitala J, Harvima IT. 2016. Archives of dermatological research. [first online 27 July 2017]: 1-10 A1 Journal article (refereed), original research
Immediate Wheal Reactivity to Autologous Sweat in Atopic Dermatitis Is Associated with Clinical Severity, Serum Total and Specific IgE and Sweat Tryptase Activity
Ilves T, Virolainen A, Harvima IT. 2016. International archives of allergy and immunology. 170: 84-91 A1 Journal article (refereed), original research
Increased mitogen-stimulated lymphocyte proliferation is associated with the clinical response in major depressive disorder in women: A follow-up study
Elomaa Antti-Pekka, Viinamäki Heimo, Harvima Ilkka T, Koivumaa-Honkanen, Honkalampi Kirsi, Valkonen-Korhonen Minna, Lehti Soili M. 2016. Psychiatry research. 239: 220-221 A1 Journal article (refereed), original research
Kansallinen ihosyöpäohjelma tarvitaan nyt
Harvima Ilkka, Kähäri Veli-Matti, Ranki Annamari, Snellman Erna, Tasanen-Määttä Kaisa. 2016. Lääkärilehti. 71: 462-463 D1 Article in a trade journal
Epidermal Expression of Filaggrin/Profilaggrin Is Decreased in Atopic Dermatitis: Reverse Association With Mast Cell Tryptase and IL-6 but Not With Clinical Severity
Ilves Tiina, Tiitu Virpi, Suttle Mireille-Maria, Saarinen Jari Vilho, Harvima Ilkka Tapani. 2015. Dermatitis. 26: 260-267 A1 Journal article (refereed), original research
Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma
Siiskonen Hanna, Poukka Mari, Bykachev Andrey, Tyynelä-Korhonen Kristiina, Sironen Reijo, Pasonen-Seppänen Sanna, Harvima Ilkka T. 2015. Melanoma research. [epub ahead of print 27 July 2015]: - A1 Journal article (refereed), original research
Mast cell chymase in experimentally induced psoriasis
Suttle Mireille-Maria, Harvima Ilkka T. 2015. Journal of dermatology. 2016; 43: 693-696 A1 Journal article (refereed), original research
Mast cell tryptase and chymase in the progress of cutaneous vasculitis
Lipitsä Tiina, Naukkarinen Anita, Harvima Ilkka T. 2015. Archives of dermatological research. 307: 917-924 A1 Journal article (refereed), original research
Mast cells express CYP27A1 and CYP27B1 in epithelial skin cancers and psoriasis
Kaukinen Antti, Pelkoonen Jukka, Harvima Ilkka T. 2015. European journal of dermatology. [epub ahead of print]: - A1 Journal article (refereed), original research
Decrease in Chymase Activity is Associated with Increase in IL-6 Expression in Mast Cells in Atopic Dermatitis
Ilves T, Harvima I. 2014. Acta dermato-venereologica. Epub: -- A1 Journal article (refereed), original research
Experimentally Induced Psoriatic Lesions Associate with Rapid but Transient Decrease in Interleukin-33 Immunostaining in Epidermis
Suttle MM, Enoksson M, Zoltowska A, Chatterjee M, Nilsson G, Harvima IT. 2014. Acta dermato-venereologica. 95: 536-541 A1 Journal article (refereed), original research
Increased Numbers of Tryptase-Positive Mast Cells in the Healthy and Sun-Protected Skin of Tobacco Smokers
Kaukinen A, Fitzgibbon A, Oikarinen A, Hinkkanen L, Viinikanoja M, Harvima IT. 2014. Dermatology. 229: 353-358 A1 Journal article (refereed), original research
Molecular targets on mast cells and basophils for novel therapies
Harvima Ilkka T, Levi-Schaffer Francesca, Draber Petr, Friedman Sheli, Polakovicova Iva, Gibbs Bernhard F, Blank Ulrich, Nilsson Gunnar, Maurer Marcus. 2014. Journal of allergy and clinical immunology. 134: 530-544 A2 Review article, Literature review, Systematic review
Reduced serum adiponectin levels in alexithymia
Honkalampi K, Viinamäki H, Niskanen L, Koivumaa-Honkanen H, Valkonen-Korhonen M, Elomaa AP, Harvima I, Herzig KH, Lehto SM. 2014. Neuroimmunomodulation. 21: 234-239 A1 Journal article (refereed), original research
Anti-apoptotic bfl-1 is the major effector in activation-induced human mast cell survival
Ekoff M, Lyberg K, Krajewska M, Arvidsson M, Rak S, Reed JC, Harvima I, Nilsson G. 2012. PLoS ONE. 7: e39117; 1-7 A1 Journal article (refereed), original research
Elevated levels of serum IL-5 are associated with an increased likelihood of major depressive disorder
Elomaa A-P, Niskanen L, Herzig K-H, Viinamäki H, Hintikka J, Koivumaa-Honkanen H, Honkalampi K, Valkonen-Korhonen M, Harvima I, Lehto SM. 2012. Bmc psychiatry. 12: 2 A1 Journal article (refereed), original research
Experimentally induced psoriatic lesion associates with interleukin (IL)-6 in mast cells and appearance of dermal cells expressing IL-33 and IL-6 receptor
Suttle, M.-M; Nilsson, G; Snellman, E; Harvima IT. 2012. Clinical and experimental immunology. 169: 311-319 A1 Journal article (refereed), original research
Glukokortikoidien yhteys masennuksen syntyyn ja oirekuvaan
Viinamäki, Heimo; Lehto, Soili M.; Palvimo, Jorma J., Harvima, Ilkka; Valkonen-Korhonen, Minna; Koivumaa-Honkanen, Heli; Hintikka, Jukka; Honkalampi, Kirsi ja Niskanen Leo. 2012. Duodecim. 128: 1022-1029 A2 Review article, Literature review, Systematic review
OX40 ligand and OX40 are increased in atopic dermatitis lesions but do not correlate with clinical severity
Ilves T, Harvima I. 2012. Journal of the european academy of dermatology and venereology. 2012: 1-9 A1 Journal article (refereed), original research
Stress, the neuroendocrine system and mast cells: current understanding of their role in psoriasis
Harvima I, Nilsson G. 2012. Expert review of clinical immunology. 8: 235-241 A1 Journal article (refereed), original research
Mast cell chymase is present in uterine cervical carcinoma and it detaches viable and growing cervical squamous carcinoma cells from substratum in vitro
Diaconu Nicolae-Costin, Rummukainen Jaana, Naukkarinen Anita, Mättö Mikko, Harvima Rauno J, Pelkonen Jukka, Harvima Ilkka T.. 2011. Archives of dermatological research. 303: 499-512 A1 Journal article (refereed), original research
Mast cells as regulators of skin inflammation and immunity
Harvima IT, Nilsson G. 2011. Acta dermato-venereologica. 91: 644-650 A2 Review article, Literature review, Systematic review
Human mast cells adhere to and migrate on epithelial and vascular basement membrane laminins LM-332 and LM-511 via alpha(3)beta(1) integrin
Sime W, Lunderius-Andersson C, Enoksson M, Rousselle P, Tryggvason K, Nilsson G, Harvima I, Patarroyo M. 2009. Journal of immunology. 183: 4657-4665 A1 Journal article (refereed), original research
Cervical squamous carcinoma cells are resistant to the combined action of tumor necrosis factor-alpha and histamine whereas normal keratinocytes undergo cytolysis
Diaconu N-C, Rummukainen J, Mättö M, Naukkarinen A, Harvima RJ, Pelkonen J, Harvima IT. 2008. Bmc cancer. 8: [15, art. 46] A1 Journal article (refereed), original research
Induction of matrix metalloproteinase-9 in keratinocytes by histamine
Harvima IT. 2008. Journal of investigative dermatology. 128: 2748-50 A1 Journal article (refereed), original research
Is there a role for mast cells in psoriasis?
Harvima IT, Nilsson G, Suttle MM, Naukkarinen A. 2008. Archives of dermatological research. 300: 461-78 A1 Journal article (refereed), original research
Expression of 15-lipoxygenase type-1 in human mast cells
Gulliksson M, Brunnström A, Johannesson M, Backman L, Nilsson G, Harvima I, Dahlén B, Kumlin M, Claesson HE. 2007. Biochimica et biophysica acta: international journal of biochemistry and biophysics. 1771: 1156-1165 A1 Journal article (refereed), original research
Histamine, but not leukotriene C4, is an essential mediator in cold urticaria wheals
Nuutinen P, Harvima IT, Ackermann L. 2007. Acta dermato-venereologica. 87: 9-13 A1 Journal article (refereed), original research
Increase in CD30 ligand/CD153 and TNF-alpha expressing mast cells in basal cell carcinoma
Diaconu NC, Kaminska R, Naukkarinen A, Harvima RJ, Nilsson G, Harvima IT. 2007. Cancer immunology immunotherapy. 56: 1407-1415 A1 Journal article (refereed), original research
Juvenile-onset neuronal ceroid lipofuscinosis with infantile CNL1 mutation and palmitoyl-protein thioesterase deficiency
Kälviäinen R, Eriksson K, Losekoot M, Sorri I, Harvima I, Santavuori P, Järvelä I, Autti T, Vanninen R, Salmenperä T, van Diggelen OP. 2007. European journal of neurology. 14: 369-372 A1 Journal article (refereed), original research
The increase in tryptase- and chymase-positive mast cells is associated with partial inactivation of chymase and increase in protease inhibitors in basal cell carcinoma
Diacony NC, Kaminska R, Naukkarinen A, Harvima R, Harvima I. 2007. Journal of the european academy of dermatology and venereology. 21: 908-915 A1 Journal article (refereed), original research
Hyaluronic acid inhibits the adherence and growth of monolayer keratinocytes but does not affect the growth of keratinocyte epithelium
Harvima IT, Heikura H, Hyttinen M, Naukkarinen A. 2006. Archives of dermatological research. 298: 207-219 A1 Journal article (refereed), original research
Mast cell CD30 ligand is upregulated in cutaneus inflammation and mediates degranulation-independent chemokine secretion
Fischer M, Harvima IT, Carvalho RFS, Möller C, Naukkarinen A, Enblad G, Nilsson G. 2006. Journal of clinical investigation. 116: 2748-2756 A1 Journal article (refereed), original research
CC chemokine receptors CCR1 and CCR4 are expressed on airway mast cells in allergic asthma
Amin K, Janson C, Harvima I, Venge P, Nilsson G. 2005. Journal of allergy and clinical immunology. 116: 1383-386 A1 Journal article (refereed), original research
Effect of temporin A modifications on its cytotoxicity and antimicrobial activity
Mäntylä T, Sirola H, Kansanen E, Korjamo T, Lankinen H, Lappalainen K, Välimaa AL, Harvima I, Närvänen A. 2005. Apmis. 113: 497-505 A1 Journal article (refereed), original research
Efficacy of dietary hempseed oil in patients with atopic dermatitis
Callaway J, Schwab U, Harvima I, Halonen P, Mykkänen O, Hyvönen P, Järvinen T. 2005. Journal of dermatological treatment. 16: 87-94 A1 Journal article (refereed), original research
Mast cell tryptase and chymase in chronic leg ulcers: chymase is potentially destructive to epithelium and is contolled by proteinase inhibitors
Huttunen M, Harvima IT. 2005. British journal of dermatology. 152: 1149-1160 A1 Journal article (refereed), original research
Study of innervation, sensory neuropeptides, and serotonin in murine contact allergic skin
El-Nour H, Lundeberg L, Boman A, Beck O, Harvima IT, Theodorsson E, Nordlind K. 2005. Immunopharmacology and immunotoxicology. 27: 67-76 A1 Journal article (refereed), original research
Heparin modulates the growth and adherence and augments the gowth-inhibitory action of TNF-alpha on cultured human keratinocytes
Harvima IT, Lappalainen K, Hirvonen MR, Matto M, Kivinen PK, Hyttinen M, Pelkonen J, Naukkarinen A. 2004. Journal of cellular biochemistry. 92: 372-386 A1 Journal article (refereed), original research
The production of collagen and the activity of mast-cell chymase increase in human skin after irridation therapy
Riekki R, Harvima IT, Jukkola A, Risteli J, Oikarinen A. 2004. Experimental dermatology. 13: 364-71 A1 Journal article (refereed), original research
A closed unventilated chamber for the measurement of transepidermal water loss
Nuutinen J, Alanen E, Autio P, Lahtinen M-R, Harvima I, Lahtinen T. 2003. Skin research and technology. 9: 85-89 A1 Journal article (refereed), original research
Bergeyella zoohelcum septicaemia of a patient suffering from severe skin infection
Kivinen PK, Lahtinen M-R, Ruotsalainen E, Harvima IT, Katila M-L. 2003. Acta dermato-venereologica
Mast cell survival and apoptosis in organ-cultured human skin
Kivinen PK, Nilsson G, Naukkarinen A, Harvima IT. 2003. Experimental dermatology. 12: 53-60 A1 Journal article (refereed), original research
Mast cells, nerves and neuropeptides in atopic dermatitis and nummular eczema
Järvikallio A, Harvima IT, Naukkarinen A. 2003. Archives of dermatological research. 295: 2-7 A1 Journal article (refereed), original research
Retinoic acid inhibits in vitro development of mast cells but has no marked effect on mature human skin tryptase- and chymase-positive mast cells
Hjertson M, Kivinen PK, Dimberg L, Nilsson K, Harvima IT, Nilsson G. 2003. Journal of investigative dermatology. 120: 239-245 A1 Journal article (refereed), original research
Water loss through the lip, nail, eyelid skin, scalp skin, and axillary skin measured with a closed-chamber evaporation principle
Nuutinen J, Harvima I, Lahtinen M-R, Lahtinen T. 2003. British journal of dermatology. 148: 839-841 A1 Journal article (refereed), original research
Transient production of stem cell factor in dermal cells but increasing expression of Kit receptor in mast cells during normal wound healing
Huttunen M, Naukkarinen A, Horsmanheimo M, Harvima IT. 2002. Archives of dermatological research. 294: 324-330 A1 Journal article (refereed), original research
Inhibition of keratinocyte growth in cell culture and whole skin culture by mast cell mediators
Huttunen M, Hyttinen M, Nilsson G, Butterfield JH, Horsmanheimo M, Harvima IT. 2001. Experimental dermatology. 10: 184-192 A1 Journal article (refereed), original research
Interleukin-4-posituve mast cells are highly associated with the extent of immediate allergic wheal reaction in the skin
Saarinen JV, Harvima RJ, Horsmanheimo M, Harvima IT, Naukkarinen A. 2001. Allergy. 56: 58-64 A1 Journal article (refereed), original research
Kroonisten säärihaavojen hoito edellyttää yhteistyötä ja tehokkaita menetelmiä
Harvima I. 2001. NOVARTIS NEWS. 1: 32-34 D1 Article in a trade journal
Mast cells express functional CD30 ligand and are the predominant CD30L-positive cells in Hodgkin's disease
Molin D, Fischer M, Xiang Z, Larsson U, Harvima I, Venge P, Nilsson K, Sundstrom C, Enblad G, Nilsson G. 2001. British journal of haematology. 114: 616-623 A1 Journal article (refereed), original research
Modulation of the immediate allergic wheal reaction in the skin by drugs inhibiting the effects on leukotriene C4 and prostaglandin D2
Saarinen JV, Harvima RJ, Horsmanheimo M, Harvima IT. 2001. European journal of clinical pharmacology. 57: 1-4 A1 Journal article (refereed), original research
Release of soluble tryptase but only minor amounts of chymase activity from cutaneous mast cells
Kivinen PK, Kaminska R, Naukkarinen A, Harvima RJ, Horsmanheimo M, Harvima IT. 2001. Experimental dermatology. 10: 246-255 A1 Journal article (refereed), original research
The release of histamine is associated with the inactivation of mast cell chymase during immediate allergic wheal reaction in the skin
Saarinen JV, Harvima RJ, Naukkarinen A, Horsmanheimo M, Harvima IT. 2001. Clinical and experimental allergy. 31: 593-601 A1 Journal article (refereed), original research
Alterations in mast cells showing tryptase and chymase activity in epithelializatingand chronic wounds
Huttunen M, Aalto M-L, Harvima RJ, Horsmanheimo M, Harvima IT. 2000. Experimental dermatology. 9: 258-265 A1 Journal article (refereed), original research
Bee venom induces high histamine or high leukotriene C4 release in skin of sensitized beekeepers
Annila I, Saarinen JV, Nieminen MM, Moilanen E, Hahtola P, Harvima IT. 2000. Journal of investigational allergology and clinical immunology. 10: 223-228 A1 Journal article (refereed), original research
Histamine and LTC4 in stinging nettle-induced urticaria
Taskila K, Saarinen JV, Harvima IT, Harvima RJ. 2000. Allergy. 55: 679-680 A1 Journal article (refereed), original research
Kun tutkija yrittää julkaista tutkimuksensa... Kokeneiden tutkijoiden näkökulmia käsikirjoituksen tarjoamisesta tieteelliseen lehteen
Harvima R, Harvima I. 2000. LÄÄKÄRISANOMAT. : 31 D1 Article in a trade journal
Lääkkeiden käytön ja ihoreaktioiden kuvauksen sekä kirjaamisen tärkeys myöhemmälle diagnostiikalle
Harvima R, Laukkanen A, Harvima I, Mattila R, Hollmén A. 2000. Lääkärilehti. 55: 2195-2196 A1 Journal article (refereed), original research
Release of histamine and leukotriene C4 in immendiate allergic wheal reaction as measured with microdialysis techinique
Saarinen JV, Harvima RJ, Naukkarinen A, Horsmanheimo M, Harvima IT. 2000. Archives of dermatological research. 292: 333-340 A1 Journal article (refereed), original research
The chemokine receptor CXCR4 is expressed within the mast cell lineage and its ligand stromal cell-derived factor-1alfa acts as a mast cell chemotaxin
Juremalm M, Hjertson M, Olsson N, Harvima I, Nilsson K, Nilsson G. 2000. European journal of immunology. 30: 3614-3622 A1 Journal article (refereed), original research
Cultured allogeneic skin cells are effective in the treatment of chronic diabetic leg and foot ulcers
Harvima IT, Virnes S, Kauppinen L, Huttunen M, Kivinen P, Niskanen L, Horsmanheimo M. 1999. Acta dermato-venereologica. 79: 217-220 A1 Journal article (refereed), original research
Decreased chymase activity is associated with increased levels of protease inhibitors in mast cells of psoriatic lesions
Harvima IT, Haapanen L, Ackermann L, Naukkarinen A, Harvima RJ, Horsmanheimo M. 1999. Acta dermato-venereologica. 79: 98-104 A1 Journal article (refereed), original research
Focal dermal-epidermal separation and fibronectin cleavage in basement membrane by human mast cell tryptase
Kaminska R, Helisalmi P, Harvima RJ, Naukkarinen A, Horsmanheimo M, Harvima IT. 1999. Journal of investigative dermatology. 113: 567-573 A1 Journal article (refereed), original research
Identification and characterization of multiple forms of tryptase from human mast cells
Harvima RJ, Harvima IT, Dull D, Dunder UK, Schwartz LB. 1999. Archives of dermatological research. 291: 73-80 A1 Journal article (refereed), original research
Mast cells in developing subepidermal bullous diseases: emphasis on tryptase, chymase and protease inhibitors
Kaminska R, Naukkarinen A, Glinski W, Horsmanheimo M, Harvima IT. 1999. Acta dermato-venereologica. 79: 351-355 A1 Journal article (refereed), original research
Mast cells in psoriatic skin are strongly positive for interferon-gamma
Ackermann L, Harvima IT, Pelkonen J, Ritamäki-Salo V, Naukkarinen A, Harvima RJ, Horsmanheimo M. 1999. British journal of dermatology. 140: 624-633 A1 Journal article (refereed), original research
Papillary hypertrophy of the upper tarsal conjunctiva during contact lens wear: a 4-month study with ethyl-6-O-decanoyl-glucoside
Vaahtoranta-Lehtonen HH, Lehtonen OP, Harvima I, Peltola O, Nikoskelainen E. 1999. CLAO JOURNAL. 25: 105-108 A1 Journal article (refereed), original research
Pyoderma gangraenosumin paikallishoito kromoglikaattiliuoksella
Harvima RJ, Hollmén A, Mattila R, Kaipiainen-Seppänen O, Harvima IT, Kaminska R, Laukkanen A, Räsänen L, Horsmanheimo M. 1999. Duodecim. 115: 2085-2090 A1 Journal article (refereed), original research
Quantitative digital image analysis applied to demonstrate the stratified distribution of involucrin in organ cultured human skin
Kivinen PK, Hyttinen M, Harvima RJ, Naukkarinen A, Horsmanheimo M, Harvima IT. 1999. Archives of dermatological research. 291: 217-223 A1 Journal article (refereed), original research
Suction blister formation in skin after acute and repeated mast cell degranulation
Kaminska R, Naukkarinen A, Horsmanheimo M, Harvima IT. 1999. Acta dermato-venereologica. 79: 191-194 A1 Journal article (refereed), original research
Diabeetikon jalkahaavaumien uudet aktiivisemmat hoitomuodot
Harvima I. 1998. DIABETES JA LÄÄKÄRI. : 8-16 D1 Article in a trade journal
Mast cells of psoriatic and atopic dermatitis skin are positive for TNF-alpha and their degranulation is associated with expression of ICAM-1 in the epidermis
Ackermann L, Harvima IT. 1998. Archives of dermatological research. 290: 353-359 A1 Journal article (refereed), original research
Staphylococcal enterotoxin B inhibits the production of interleukin-4 in a human mast-cell line HMC-1
Ackermann L, Pelkonen J, Harvima IT. 1998. Immunology. 94: 247-252 A1 Journal article (refereed), original research
Quantitative analysis of tryptase and chymase containing mast cells in benign and malignant breast lesions
Kankkunen J-P, Harvima IT, Naukkarinen A. 1997. International journal of cancer. 72: 385-388 A1 Journal article (refereed), original research
Quantitative analysis of tryptase- and chymase-containing mast cells in atopic dermatitis and nummular eczema
Järvikallio A, Naukkarinen A, Harvima IT, Aalto M-L, Horsmanheimo M. 1997. British journal of dermatology. 136: 871-877 A1 Journal article (refereed), original research
Alterations in mast cell proteinases and protease inhibitors in the progress of cutaneous herpes zoster infection
Kaminska R, Harvima IT, Naukkarinen A, Nilsson G, Horsmanheimo M. 1996. Journal of pathology. 180: 434-440 A1 Journal article (refereed), original research
Association of psychic stress with clinical severity and symptoms of psoriatic patients
Harvima RJ, Viinamäki H, Harvima IT, Naukkarinen A, Savolainen L, Aalto M-L, Horsmanheimo M. 1996. Acta dermato-venereologica. 76: 467-471 A1 Journal article (refereed), original research
Histamine and leukotriene C4 release in cutaneous mosquito-bite reactions
Horsmanheimo L, Harvima IT, Harvima RJ, Brummer-Korvenkontio H, Francois G, Reunala T. 1996. Journal of allergy and clinical immunology. 98: 408-411 A1 Journal article (refereed), original research
Histamine release in skin monitored with the mikrodialysis technique does not correlate with the weal size induced by cow allergen
Horsmanheimo L, Harvima IT, Harvima RJ, Ylönen J, Naukkarinen A, Horsmanheimo M. 1996. British journal of dermatology. 134: 94-100 A1 Journal article (refereed), original research
Kun nuori nainen valittaa tukan lähtöä
Harvima R, Harvima I. 1996. Lääkärilehti. 51: 1799-1801 A2 Review article, Literature review, Systematic review
Neuropeptide- and capsaicin-induced histamine release in skin monitored with the microdialysis technique
Huttunen M, Harvima IT, Ackermann L, Harvima RJ, Naukkarinen A, Horsmanheimo M. 1996. Acta dermato-venereologica. 76: 205-209 A1 Journal article (refereed), original research
Palovammojen hoito
Härmä M, Ruokonen E, Harvima I, Takala J. 1996. Duodecim. 112: 1455-1462 A2 Review article, Literature review, Systematic review
Quantitative histochemical analysis of mast cells and sensory nerves in psoriatic skin
Naukkarinen A, Järvikallio A, Lakkakorpi J, Harvima IT, Harvima RJ, Horsmanheimo M. 1996. Journal of pathology. 180: 200-205 A1 Journal article (refereed), original research
Stem cell factor-dependent human cord blood derived mast cells express alpha- and beta-tryptase, heparin and chondroitin sulphate
Nilsson G, Blom T, Harvima I, Kusche-Gullberg M, Nilsson K, Hellman L. 1996. Immunology. 88: 308-314 A1 Journal article (refereed), original research
Demonstration of tryptase in bovine cutaneous and tumor mast cells
Welle MM, Proske SM, Harvima IT, Schechter NM. 1995. Journal of histochemistry and cytochemistry. 43: 1139-1144 A1 Journal article (refereed), original research
Skin tryptase: Features and expression in human dermatological disorders
Harvima IT, Harvima RJ, Naukkarinen A, Horsmanheimo M. Teoksessa: Caughey GH, 1995. Mast Cell Proteases in Immunology and Biology. s. 25-46. Marcel Dekker A3 Book section, Chapters in research books
Mast cell proteinases and cytokines in skin inflammation
Harvima IT, Horsmanheimo L, Naukkarinen A, Horsmanheimo M. 1994. Archives of dermatological research. 287: 61-67 A1 Journal article (refereed), original research
Mast cells are one major source of interleukin-4 in atopic dermatitis
Horsmanheimo L, Harvima IT, Järvikallio A, Harvima RJ, Naukkarinen A, Horsmanheimo M. 1994. British journal of dermatology. 131: 348-353 A1 Journal article (refereed), original research

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Ilkka Harvima

Research groups

Case: Unexpected development of severe penicillin allergy and review of literature

Erythema Multiforme in a Patient with Reactive Arthritis: Usefulness of Lymphocyte Stimulation Test for Detection of Sulfasalazine Hypersensitivity in a Case Report

Malignant and in situ subtypes of melanoma are associated with basal and squamous cell carcinoma and its precancerous lesions

Mast cell chymase is in contact with melanoma cells in vivo and it detaches melanoma cells from the substratum in vitro

Pinoresinol stimulates keratinocyte proliferation and downregulates TNF‐α secretion in peripheral blood mononuclear cells: An experimental in vitro study

Regular use of vitamin D supplement is associated with fewer melanoma cases compared to non-use: a cross-sectional study in 498 adult subjects at risk of skin cancers

Sequential Increase in Complement Factor I, iC3b, and Cells Expressing CD11b or CD14 in Cutaneous Vasculitis

Survival from cutaneous malignant melanoma is improving, but is it because of a trend in decreasing melanoma thickness or the advent of new ‘revolutionary’ therapeutics?

The Use of Lymphocyte Stimulation Test in Severe Nabumetone-Induced Stevens-Johnson Syndrome: A Case Report

Association of Elevated Serum Tryptase with Cutaneous Photodamage and Skin Cancers

Erythrasma Capitis and Diffuse Hair Loss with Patches and Eczema-a Rare but Underdiagnozed Entity?

High regional mortality due to malignant melanoma in Eastern Finland may be explained by the increase in aggressive melanoma types

Mast Cells in Human Cutaneous Neurofibromas: Density, Subtypes, and Association with Clinical Features in Neurofibromatosis 1

Sisters with Generalized Pustular Psoriasis Successful Treatment with Biologics

Akuutti urtikaria

Allergiseen reaktioon osallistuvat solut

Allergiset sairaudet ja astma

Angioödeemat

Ihotestit allergiadiagnostiikassa

Kontaktiallergia

Kosketusallergeenit

Krooninen indusoituva urtikaria

Krooninen spontaani urtikaria

Kroonisen urtikarian hoito

Successful treatment of iatrogenically developed cutaneous calcification by tetracycline in Labrador retriever

Urtikaria ja sen ilmeneminen

Urtikariaa muistuttavia ihoraktioita aiheuttavat taudit

Mast Cells Are a Marked Source for Complement C3 Products That Associate with Increased CD11b-Positive Cells in Keratinocyte Skin Carcinomas

Mast Cells and Sensory Nerves Contribute to Neurogenic Inflammation and Pruritus in Chronic Skin Inflammation

Mast cell chymase degrades fibrinogen and fibrin

Accuracy and reliability of a hand-held in vivo skin indentation device to assess skin elasticity

Increase in FoxP3-positive Cells and Their Contacts with Mast Cells in Köbner-negative Patients with Psoriasis after Tape-stripping

Mast cell-neural interactions contribute to pain and itch

CD40 Ligand Is Increased in Mast Cells in Psoriasis and Actinic Keratosis but Less So in Epithelial Skin Carcinomas

Immunoreactivity to CYP24A1, but not vitamin D receptor, is increased in mast cells of keratinocyte skin cancers

Melanooman riskitekijät

Complement C3 is expressed by mast cells in cutaneous vasculitis and is degraded by chymase

Immediate Wheal Reactivity to Autologous Sweat in Atopic Dermatitis Is Associated with Clinical Severity, Serum Total and Specific IgE and Sweat Tryptase Activity

Increased mitogen-stimulated lymphocyte proliferation is associated with the clinical response in major depressive disorder in women: A follow-up study

Kansallinen ihosyöpäohjelma tarvitaan nyt

Epidermal Expression of Filaggrin/Profilaggrin Is Decreased in Atopic Dermatitis: Reverse Association With Mast Cell Tryptase and IL-6 but Not With Clinical Severity

Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma

Mast cell chymase in experimentally induced psoriasis

Mast cell tryptase and chymase in the progress of cutaneous vasculitis

Mast cells express CYP27A1 and CYP27B1 in epithelial skin cancers and psoriasis

Decrease in Chymase Activity is Associated with Increase in IL-6 Expression in Mast Cells in Atopic Dermatitis

Experimentally Induced Psoriatic Lesions Associate with Rapid but Transient Decrease in Interleukin-33 Immunostaining in Epidermis

Increased Numbers of Tryptase-Positive Mast Cells in the Healthy and Sun-Protected Skin of Tobacco Smokers

Molecular targets on mast cells and basophils for novel therapies

Reduced serum adiponectin levels in alexithymia

Anti-apoptotic bfl-1 is the major effector in activation-induced human mast cell survival

Elevated levels of serum IL-5 are associated with an increased likelihood of major depressive disorder

Experimentally induced psoriatic lesion associates with interleukin (IL)-6 in mast cells and appearance of dermal cells expressing IL-33 and IL-6 receptor

Glukokortikoidien yhteys masennuksen syntyyn ja oirekuvaan

OX40 ligand and OX40 are increased in atopic dermatitis lesions but do not correlate with clinical severity

Stress, the neuroendocrine system and mast cells: current understanding of their role in psoriasis

Mast cell chymase is present in uterine cervical carcinoma and it detaches viable and growing cervical squamous carcinoma cells from substratum in vitro

Mast cells as regulators of skin inflammation and immunity

Human mast cells adhere to and migrate on epithelial and vascular basement membrane laminins LM-332 and LM-511 via alpha(3)beta(1) integrin

Cervical squamous carcinoma cells are resistant to the combined action of tumor necrosis factor-alpha and histamine whereas normal keratinocytes undergo cytolysis

Induction of matrix metalloproteinase-9 in keratinocytes by histamine

Is there a role for mast cells in psoriasis?

Expression of 15-lipoxygenase type-1 in human mast cells

Histamine, but not leukotriene C4, is an essential mediator in cold urticaria wheals

Increase in CD30 ligand/CD153 and TNF-alpha expressing mast cells in basal cell carcinoma

Juvenile-onset neuronal ceroid lipofuscinosis with infantile CNL1 mutation and palmitoyl-protein thioesterase deficiency

The increase in tryptase- and chymase-positive mast cells is associated with partial inactivation of chymase and increase in protease inhibitors in basal cell carcinoma

Hyaluronic acid inhibits the adherence and growth of monolayer keratinocytes but does not affect the growth of keratinocyte epithelium

Mast cell CD30 ligand is upregulated in cutaneus inflammation and mediates degranulation-independent chemokine secretion

CC chemokine receptors CCR1 and CCR4 are expressed on airway mast cells in allergic asthma

Effect of temporin A modifications on its cytotoxicity and antimicrobial activity

Efficacy of dietary hempseed oil in patients with atopic dermatitis

Mast cell tryptase and chymase in chronic leg ulcers: chymase is potentially destructive to epithelium and is contolled by proteinase inhibitors

Study of innervation, sensory neuropeptides, and serotonin in murine contact allergic skin

Heparin modulates the growth and adherence and augments the gowth-inhibitory action of TNF-alpha on cultured human keratinocytes

The production of collagen and the activity of mast-cell chymase increase in human skin after irridation therapy

A closed unventilated chamber for the measurement of transepidermal water loss

Bergeyella zoohelcum septicaemia of a patient suffering from severe skin infection