JANNE MäKELä

Postdoctoral Researcher

Contrast media and biolubricants for early diagnosis and treatment of osteoarthritis.

Currently interested in contrast media and biolubricants in the early diagnosis and treatment of osteoarthritis. What is the potential of new contrast media in imaging of articular cartilage? How do you best use radiographic imaging to monitor the progression of osteoarthritis over time, and how does a synthetic biopolymer, that lubricates and reinforces the tissue, slow down the disease progression?

Contact info

Organization

Faculty of Science and Forestry, Department of Applied Physics

Email

janne.makela@uef.fi

Phone

+358 50 477 1708

Keywords

biomechanics cartilage computed tomography medical imaging medical physics modelling osteoarthritis tribology

Research groups

Biophysics of Bone and Cartilage (BBC)

Link Youtube: How osteoarthritis is studied and treated (in Finnish)?
Link Animation: Experimental Articular Cartilage Strain Replication Using Finite Element Model Optimization

Publications

Sarin, Jaakko K; Te Moller, Nikae Cr; Mohammadi, Ali; Prakash, Mithilesh; Torniainen, Jari; Brommer, Harold; Nippolainen, Ervin; Shaikh, Rubina; Mäkelä, Janne Ta; Korhonen, Rami K; René van Weeren, P; Afara, Isaac O; Töyräs, Juha. 2021. Machine learning augmented near-infrared spectroscopy: In vivo follow-up of cartilage defects Osteoarthritis and cartilage [Publ online December 21, 2020]: 1-39. 2021
Bhattarai, Abhisek; Mäkelä, Janne T A; Pouran, Behdad; Kröger, Heikki; Weinans, Harrie; Grinstaff, Mark W; Töyräs, Juha; Turunen, Mikael J. 2020. Effects of Human Articular Cartilage Constituents on Simultaneous Diffusion of Cationic and Non-ionic Contrast Agents Journal of orthopaedic research [Epub ahead of print 28 Aug 2020]: 1-9. 2020
Bhattarai, Abhisek; Pouran, Behdad; Mäkelä, Janne T A; Shaikh, Rubina; Honkanen, Miitu K M; Prakash, Mithilesh; Kröger, Heikki; Grinstaff, Mark W; Weinans, Harrie; Jurvelin, Jukka S; Töyräs, Juha. 2020. Dual Contrast in Computed Tomography Allows Earlier Characterization of Articular Cartilage over Single Contrast Journal of orthopaedic research 38 10: 2230-2238. 2020
Lawson, TB; Mäkelä, JTA; Klei, T; Snyder, BD; Grinstaff, MW. 2020. Nanotechnology and Osteoarthritis. Part 2: Opportunities for Advanced Devices and Therapeutics Journal of orthopaedic research [Publ online 22 September 2020]: 1-12. 2020
Lawson, TB; Mäkelä, JTA; Klein, T; Snyder, BD; Grinstaff, MW. 2020. Nanotechnology and Osteoarthritis. Part 1: Clinical Landscape and Opportunities for Advanced Diagnostics Journal of orthopaedic research [Publ online 14 September 2020]: 1-8. 2020
Nelson, Brad B; Mäkelä, Janne TA; Lawson, Taylor B; Patwa, Amit N; Snyder, Brian D; McIlwraith, C Wayne; Grinstaff, Mark W; Goodrich, Laurie R; Kawcak, Chris E. 2020. Cationic contrast-enhanced computed tomography distinguishes between reparative, degenerative and healthy equine articular cartilage Journal of orthopaedic research [Published 02 November 2020]: 1-11. 2020
Te Moller, Nikae CR; Mohammadi, Ali; Plomp, Saskia; Serra Bragança, Filipe M; Beukers, Martijn; Pouran, Behdad; Afara, Isaac O; Nippolainen, Ervin; Mäkelä, Janne TA; Korhonen, Rami K; Töyräs, Juha; Brommer, Harold; René van Weeren, P. 2020. Structural, compositional, and functional effects of blunt and sharp cartilage damage on the joint: a 9-month equine groove model study Journal of orthopaedic research [Published online 24 Dec 2020]: 1-29. 2020
Anilkumar, Parambath; Lawson, Taylor B; Abbina, Srinivas; Mäkelä, Janne; Sabatelle, Robert; Takeuchi, Lily; Snyder, Brian; Grinstaff, Mark; Kizhakkedathu, Jayachandran. 2020. Mega macromolecules as single molecule lubricants for hard and soft surfaces Nature communications 11 1: 2139. 2020
Ojanen, Simo Pekka; Finnilä, Mikko Arttu Jalmari; Mäkelä, Janne; Saarela, Kiira; Happonen, Emilia; Herzog, Walter; Saarakkala, Simo; Korhonen, Rami Kristian. 2019. Anterior cruciate ligament transection of rabbits alters composition, structure and biomechanics of articular cartilage and chondrocyte deformation 2 weeks post-surgery in a site-specific manner Journal of biomechanics 2020; 98: 109450. 2019
Janne T. A. Mäkelä. 2016. Kudosnesteen virtauksen muutokset nivelrustossa voivat ennustaa nivelrikon alkamista NIVELTIETO 2: 11-13. 2016
Mäkelä Janne. 2016. Structural and functional alterations of articular cartilage in osteoarthritis. Itä-Suomen yliopisto. Publications of the University of Eastern Finland. Dissertations in Forestry and Natural Sciences 214. 2016
Mäkelä JT, Korhonen RK. 2016. Highly nonlinear stress-relaxation response of articular cartilage in indentation: Importance of collagen nonlinearity Journal of biomechanics 49: 1734-1741. 2016
Puhakka PH, Te Moller NC, Afara IO, Mäkelä JT, Tiitu V, Korhonen RK, Brommer H, Virén T, Jurvelin JS, Töyräs J. 2015. Estimation of articular cartilage properties using multivariate analysis of optical coherence tomography signal. OSTEOARTHRITIS AND CARTILAGE 23 12: 2206-2213. 2015
Danso EK, Mäkelä JTA, Tanska P, Mononen ME, Honkanen JTJ, Jurvelin JS, Töyräs J, Julkunen P, Korhonen RK. 2015. Characterization of site-specific biomechanical properties of human meniscus-Importance of collagen and fluid on mechanical nonlinearities. JOURNAL OF BIOMECHANICS 48 8: 1499-1507. 2015
Mäkelä JTA, Han S-K, Herzog W, Korhonen RK. 2015. Very early osteoarthritis changes sensitively fluid flow properties of articular cartilage. JOURNAL OF BIOMECHANICS -: -. 2015
Florea Cristina, Malo Markus KH, Rautiainen Jari, Mäkelä Janne TA, Fick James M, Nieminen Miika T, Jurvelin Jukka S, Davidescu Arjana, Korhonen Rami K. 2014. Alterations in subchondral bone plate, trabecular bone and articular cartilage properties of rabbit femoral condyles at 4 weeks after anterior cruciate ligament transection. OSTEOARTHRITIS AND CARTILAGE [Epub ahead of print]: [Epub ahead of print]. 2014
Huttu Mari RJ, Puhakka Jani, Mäkelä Janne TA, Takakubo Yuya, Tiitu Virpi, Saarakkala Simo, Konttinen Yrjö T, Kiviranta Ilkka, Korhonen Rami K. 2014. Cell-tissue interactions in osteoarthritic human hip joint articular cartilage. CONNECTIVE TISSUE RESEARCH 55 4: 282-91. 2014
Makela JTA, Herzog W, Korhonen RK. 2014. Collagen content is increased in lapine femoral condyle cartilage four weeks after anterior cruciate ligament transection: Orthopaedic Research Society, Transactions of the Orthopaedic Research Society. 1226. 2014
Mäkelä JTA, Rezaeian ZS, Mikkonen S, Madden R, Han S-K, Jurvelin JS, Herzog W, Korhonen RK.. 2014. Site-dependent changes in structure and function of lapine articular cartilage 4 weeks after anterior cruciate ligament transection. Osteoarthritis and cartilage 22 6: 869-878. 2014
Mäkelä JTA, Rezaeian ZS, Mikkonen S, Madden R, Han S-K, Jurvelin JS, Herzog W, Korhonen RK. 2013. Site-Dependent Changes in Collagen Orientation and Elastic Moduli in Lapine Articular Cartilage at 4 Weeks After Anterior Cruciate Ligament Transection, Transactions of the Orthopaedic Research Society. 1280. 2013
Huttu Mari, Puhakka Jani, Mäkelä Janne, Takakubo Yuya, Tiitu Virpi, Saarakkala Simo, Konttinen Yrjö, Kiviranta Ilkka, Korhonen Rami K. 2012. Relationships between cell volume, structure, composition and mechanical properties of osteoarthritic human hip articular cartilage: ORS, Transactions of the Orthopaedic Research Society. 1823. 2012
Makela JTA, Huttu MRJ, Korhonen R. 2012. Structure-function relationships in osteoarthritic human articular cartilage: Smith & Nephew, Inc., Transactions of the Orthopaedic Research Society. 1800. 2012
Mäkelä JTA, Huttu MR, Korhonen RK.. 2012. Structure-function relationships in osteoarthritic human hip joint articular cartilage. OSTEOARTHRITIS AND CARTILAGE 20 11: 1268-1277. 2012
Kokkonen HT, Mäkelä J, Kulmala KAM, Rieppo L, Jurvelin JS, Tiitu V, Karjalainen HM, Korhonen RK, Kovanen V, Töyräs J. 2011. Computed tomography detects changes in contrast agent diffusion after collagen cross-linking typical to natural aging of articular cartilage OSTEOARTHRITIS AND CARTILAGE 19: 1190-1198. 2011