
JANNE MäKELä
Senior Researcher
Contrast media and biolubricants for early diagnosis and treatment of osteoarthritis.
Currently interested in contrast media and biolubricants in the early diagnosis and treatment of osteoarthritis. What is the potential of new contrast media in imaging of articular cartilage? How do you best use radiographic imaging to monitor the progression of osteoarthritis over time, and how does a synthetic biopolymer, that lubricates and reinforces the tissue, slow down the disease progression?
Contact info
Organization
Faculty of Science and Forestry, Department of Applied Physics
janne.makela@uef.fi
Phone
+358 50 477 1708
Keywords
Research groups - UEF
Links
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Link Youtube: How osteoarthritis is studied and treated (in Finnish)?
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Link Animation: Experimental Articular Cartilage Strain Replication Using Finite Element Model Optimization
Publications
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Nissinen, Mikko T; Hänninen, Nina; Prakash, Mithilesh; Mäkelä, Janne TA; Nissi, Mikko J; Töyräs, Juha; Nieminen, Miika T. Korhonen, Rami K; Tanska, Petri. 2021. Functional and Structural Properties of Human Patellar Articular Cartilage in Osteoarthritis Journal of biomechanics 126: 110634. 2021
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Paakkari, Petri; Inkinen, Satu I; Honkanen, Miitu KM; Prakash, Mithilesh; Shaikh, Rubina; Nieminen, Miika T; Grinstaff, Mark W; Mäkelä, Janne TA; Töyräs, Juha; Honkanen, Juuso TJ. 2021. Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health Scientific reports 11 1: 5556. 2021
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Sarin, Jaakko K; Te Moller, Nikae Cr; Mohammadi, Ali; Prakash, Mithilesh; Torniainen, Jari; Brommer, Harold; Nippolainen, Ervin; Shaikh, Rubina; Mäkelä, Janne Ta; Korhonen, Rami K; René van Weeren, P; Afara, Isaac O; Töyräs, Juha. 2021. Machine learning augmented near-infrared spectroscopy: In vivo follow-up of cartilage defects Osteoarthritis and cartilage 29 3: 423-432. 2021
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The effect of subchondral bone plate thickness and trabecular bone volume fraction on the mechanical behavior of cartilage in post-traumatic osteoarthritis. Orava, H; Tanska, P; Huang, L; Ojanen, SP; Mäkelä, JTA; Finnilä, MAJ; Saarakkala, S; Herzog, W; Korhonen, RK; Töyräs, J / ORS Abstracts. 2021. 2021
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Anilkumar, Parambath; Lawson, Taylor B; Abbina, Srinivas; Mäkelä, Janne; Sabatelle, Robert; Takeuchi, Lily; Snyder, Brian; Grinstaff, Mark; Kizhakkedathu, Jayachandran. 2020. Mega macromolecules as single molecule lubricants for hard and soft surfaces Nature communications 11 1: 2139. 2020
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Bhattarai, Abhisek; Mäkelä, Janne T A; Pouran, Behdad; Kröger, Heikki; Weinans, Harrie; Grinstaff, Mark W; Töyräs, Juha; Turunen, Mikael J. 2020. Effects of Human Articular Cartilage Constituents on Simultaneous Diffusion of Cationic and Non-ionic Contrast Agents Journal of orthopaedic research 2021; 39 4: 771-779. 2020
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Bhattarai, Abhisek; Pouran, Behdad; Mäkelä, Janne T A; Shaikh, Rubina; Honkanen, Miitu K M; Prakash, Mithilesh; Kröger, Heikki; Grinstaff, Mark W; Weinans, Harrie; Jurvelin, Jukka S; Töyräs, Juha. 2020. Dual Contrast in Computed Tomography Allows Earlier Characterization of Articular Cartilage over Single Contrast Journal of orthopaedic research 38 10: 2230-2238. 2020
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Lawson, TB; Mäkelä, JTA; Klei, T; Snyder, BD; Grinstaff, MW. 2020. Nanotechnology and Osteoarthritis. Part 2: Opportunities for Advanced Devices and Therapeutics Journal of orthopaedic research 2021; 39 3: 473-484. 2020
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Lawson, TB; Mäkelä, JTA; Klein, T; Snyder, BD; Grinstaff, MW. 2020. Nanotechnology and Osteoarthritis. Part 1: Clinical Landscape and Opportunities for Advanced Diagnostics Journal of orthopaedic research 2021; 39 3: 465-472. 2020
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Nelson, Brad B; Mäkelä, Janne TA; Lawson, Taylor B; Patwa, Amit N; Snyder, Brian D; McIlwraith, C Wayne; Grinstaff, Mark W; Goodrich, Laurie R; Kawcak, Chris E. 2020. Cationic contrast-enhanced computed tomography distinguishes between reparative, degenerative and healthy equine articular cartilage Journal of orthopaedic research 2021; 39 8: 1647-1657. 2020