Jonna Niskanen
Doctoral Researcher
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
We are utilizing hiPSC cells to model Parkinson’s disease (LRRK2 G2019S-mutation). My focus is in PD related neuroinflammation and the effect of aggregated alphasynuclein fibrils on glial cells. I study specifically microglia cells and how the changes in the functions of these immune cells affect the motorneuron function and wellbeing.
Research groups
Publications
11/11 items-
Activation of steroid hormone receptors by metabolism-disrupting chemicals
Pitkänen, Sini; Niskanen, Jonna; Mysore, Raghavendra; Niskanen, Einari A; Palvimo, Jorma J; Pijnenburg, Dirk; van Beuningen, Rinie; Rashidian, Azam; Kronenberger, Thales; Poso, Antti; Levonen, Anna-Liisa; Küblbeck, Jenni; Honkakoski, Paavo, 2025, Toxicology and applied pharmacology, 499, 117335. A1 Journal article (refereed), original research -
Biotransformation of nanoplastics in human plasma and their permeation through a model in vitro blood-brain barrier: An in-depth quantitative analysis
Abdolahpur Monikh, Fazel; Lehtonen, Šárka; Kekäläinen, Jukka; Karkossa, Isabel; Auriola, Seppo; Schubert, Kristin; Zanut, Alessandra; Peltonen, Sanni; Niskanen, Jonna; Bandekar, Mandar; von Bergen, Martin; Leskinen, Jari TT; Koistinen, Arto; Bogialli, Sara; Guo, Zhiling; Kukkonen, Jussi VK; Chen, Chunying; Lynch, Iseult, 2024, Nano today, 59, 102466. A1 Journal article (refereed), original research -
LRRK2 G2019S Mutated iPSC-Derived Endothelial Cells Exhibit Increased α-Synuclein, Mitochondrial Impairment, and Altered Inflammatory Responses
Sonninen, Tuuli-Maria; Peltonen, Sanni; Niskanen, Jonna; Hämäläinen, Riikka H; Koistinaho, Jari; Lehtonen, Šárka, 2024, International journal of molecular sciences, 25, 23, 12874. A1 Journal article (refereed), original research -
Mutated LRRK2 induces a reactive phenotype and alters migration in human iPSC-derived pericyte-like cells
Peltonen, Sanni; Sonninen, Tuuli-Maria; Niskanen, Jonna; Koistinaho, Jari; Ruponen, Marika; Lehtonen, Šárka, 2024, Fluids and barriers of the cns, 21, 1, 92. A1 Journal article (refereed), original research -
Uptake of alpha‐synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia
Niskanen, Jonna; Peltonen, Sanni; Ohtonen, Sohvi; Fazaludeen, Mohammad Feroze; Luk, Kelvin C; Giudice, Luca; Koistinaho, Jari; Malm, Tarja; Goldsteins, Gundars; Albert, Katrina; Lehtonen, Šárka, 2024, Glia, 2025; 73, 1, 159-174. A1 Journal article (refereed), original research -
Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson’s disease related transcriptional profile and function
Ohtonen, Sohvi; Giudice, Luca; Jäntti, Henna; Fazaludeen, Mohammad Feroze; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Välimäki, Nelli-Noora; Niskanen, Jonna; Korvenlaita, Nea; Fagerlund, Ilkka; Koistinaho, Jari; Amiry-Moghaddam, Mahmood; Savchenko, Ekaterina; Roybon, Laurent; Lehtonen, Šárka; Korhonen, Paula; Malm, Tarja, 2023, Scientific reports, 13, 1, 22118. A1 Journal article (refereed), original research -
Cellular Models of Alpha-Synuclein Aggregation: What Have We Learned and Implications for Future Study
Albert, Katrina; Kälvälä, Sara; Hakosalo, Vili; Syvänen, Valtteri; Krupa, Patryk; Niskanen, Jonna; Peltonen, Sanni; Sonninen, Tuuli-Maria; Lehtonen, Šárka, 2022, Biomedicines, 10, 10, 2649. A2 Review article, Literature review, Systematic review -
Novel Bile Acid-dependent Mechanisms of Hepatotoxicity Associated with Tyrosine Kinase Inhibitors
Saran, Chitra; Sundqvist, Louise; Ho, Henry; Niskanen, Jonna; Honkakoski, Paavo; Brouwer, Kim LR, 2022, Journal of pharmacology and experimental therapeutics, 380, 2, 114-125. A1 Journal article (refereed), original research -
Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia
Albert, Katrina; Niskanen, Jonna; Kälvälä, Sara; Lehtonen, ¦árka, 2021, International journal of molecular sciences, 22, 9, 4334. A2 Review article, Literature review, Systematic review -
Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR
Küblbeck, Jenni; Niskanen, Jonna; Honkakoski, Paavo, 2020, Cells, 9, 10, 2306. A2 Review article, Literature review, Systematic review