JUHA SAVINAINEN

Contact info

Keywords

Research groups and research projects

Research groups - UEF

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  Endocannabinoid system as a drug target - Savinainen

Publications

• Della Pietra, Adriana; Giniatullin, Rashid; Savinainen, Juha R. 2021. Distinct Activity of Endocannabinoid-Hydrolyzing Enzymes MAGL and FAAH in Key Regions of Peripheral and Central Nervous System Implicated in Migraine International journal of molecular sciences 22 3: 1204. 2021
• Aaltonen, Niina; Singha, Prosanta; Jakupovic, Hermina; Wirth, Thomas; Samaranayake, Haritha; Pasonen-Seppänen, Sanna; Rilla, Kirsi; Varjosalo, Markku; Edgington-Mitchell, Laura; Kasperkiewicz, Paulina; Drag, Marcin; Kälvälä, Sara; Moisio, Eemeli; Savinainen, Juha; Laitinen, Jarmo. 2020. High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils Biological procedures online 22: 6. 2020
• Grimsey, NL; Savinainen, JR; Attili, B; Ahamed, M. 2020. Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications Drug discovery today 25 2: 330-343. 2020
• Singha, Prosanta; Mäklin, Kiira; Vihavainen, Taina; Laitinen, Tuomo; Nevalainen, Tapio; Patil, Mahadeo; Tonduru, Arun; Poso, Antti; Laitinen, Jarmo; Savinainen, Juha. 2020. Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells European journal of pharmaceutical sciences 149: 105321. 2020
• Ahonen, Tiina J; Savinainen, Juha R; Yli-Kauhaluoma, Jari: Kalso, Eija; Laitinen, Jarmo T; Moreira, Vânia M. 2018. Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A ACS Medicinal Chemistry Letters 9 12: 1269-1273. 2018
• Ahamed Muneer, Attili Bala, van Veghel Daisy, Ooms Maarten, Berben Philippe, Celen Sofie, Koole Michel, Declercq Lieven, Savinainen Juha R, Laitinen Jarmo T, Verbruggen Alfons, Bormans Guy. 2017. Synthesis and preclinical evaluation of [11C]MA-PB-1 for in vivo imaging of brain monoacylglycerol lipase (MAGL). EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 136: 104-113. 2017
• Pantsar T, Singha P, Nevalainen TJ, Koshevoy I, Leppänen J, Poso A, Niskanen JMA, Pasonen-Seppänen S, Savinainen JR, Laitinen T, Laitinen JT. 2017. Design, Synthesis, and Biological Evaluation of 2,4-Dihydropyrano[2,3-c]pyrazole Derivatives as Autotaxin Inhibitors. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 107: 97-111. 2017
• Savinainen Juha R, Navia-Paldanius Dina, Laitinen Jarmo T. 2016. A sensitive and versatile fluorescent activity assay for ABHD6. In: Maccarrone Mauro (ed.) Endocannabinoid Signaling: Methods and Protocols. Springer. Methods in Molecular Biology 1412. s. 169-178. 2016
• Savinainen Juha R, Navia-Paldanius Dina, Laitinen Jarmo T. 2016. A sensitive and versatile fluorescent activity assay for ABHD12. In: Maccarrone Mauro (ed.) Endocannabinoid Signaling: Methods and Protocols. Springer. Methods in Molecular Biology 1412. s. 179-189. 2016
• Navia-Paldanius D, Patel JZ, López Navarro M, Jakupovic H, Goffart S, Pasonen-Seppänen S, Nevalainen TJ, Jääskeläinen T, Laitinen T, Laitinen JT, Savinainen JR. 2016. Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alfa/beta-hydrolase domain containing 11 (ABHD11). EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 93: 253-263. 2016
• Aaltonen Niina, Kedzierska Ewa, Orzelska-Gorka Jolanta, Lehtonen Marko, Navia-Paldanius Dina, Jakupovic Hermina, Savinainen Juha, Nevalainen Tapio, Laitinen Jarmo T, Parkkari Teija, Gynther Mikko. 2016. In vivo characterization of the ultrapotent monoacylglycerol lipase inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl} (1H-1,2,4-triazol-1-yl)methanone (JJKK-048). JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 359: 62-72. 2016
• Manera Clementina, Malfitano Anna M, Parkkari Teija, Lucchesi Valentina, Carpi Sara, Fogli Stefano, Bertini Simone, Laezza Chiara, Ligresti Alessia, Saccomanni Giuseppe, Savinainen Juha R, Ciaglia Elena, Pisanti Simona, Gazzerro Patrizia, Di Marzo Vincenzo, Nieri Paola, Macchia Marco, Bifulco Maurizio. 2015. New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 97: 10-18. 2015
• Navia-Paldanius Dina, Aaltonen Niina, Lehtonen Marko, Savinainen Juha R, Taschler Ulrike, Radner Franz PW, Zimmermann Robert, Laitinen Jarmo T. 2015. Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 77: 180-188. 2015
• Patel Jayendra Z, Ahenkorah Stephen, Vaara Miia, Staszewski Marek, Adams Yahaya, Laitinen Tuomo, Navia-Paldanius Dina, Parkkari Teija, Savinainen Juha R, Walczynski Krzysztof, Laitinen Jarmo T, Nevalainen Tapio J. 2015. Loratadine analogues as MAGL inhibitors. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS 25 7: 1436-1442. 2015
• Patel Jayendra Z, van Bruchem John, Laitinen Tuomo, Kaczor Agnieszka A, Navia-Paldanius Dina, Parkkari Teija, Savinainen Juha R, Laitinen Jarmo T, Nevalainen Tapio J. 2015. Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors. BIOORGANIC AND MEDICINAL CHEMISTRY 23 19: 6335-6345. 2015
• Yrjölä Sari, Parkkari Teija, Navia-Paldanius Dina, Laitinen Tuomo, Kaczor Agnieszka A, Kokkola Tarja, Adusei-Mensah Frank, Savinainen Juha R, Laitinen Jarmo T, Poso Antti, Alexander Amy, Penman June, Stott Lisa, Anskat Marie, Irving Andrew J, Nevalainen Tapio J. 2015. Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 107 (2016): 119-132. 2015
• Savinainen Juha R, Patel Jayendra Z, Parkkari Teija, Navia-Paldanius Dina, Marjamaa Joona JT, Laitinen Tuomo, Nevalainen Tapio, Laitinen Jarmo T. 2014. Biochemical and Pharmacological Characterization of the Human Lymphocyte Antigen B-Associated Transcript 5 (BAT5/ABHD16A). PLOS ONE [ONLINE] 9 10: e109869. 2014
• Savinainen Juha R, Kansanen Emilia, Pantsar Tatu, Navia-Paldanius Dina, Parkkari Teija, Lehtonen Marko, Laitinen Tuomo, Nevalainen Tapio, Poso Antti, Levonen Anna-Liisa, Laitinen Jarmo T. 2014. Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL). MOLECULAR PHARMACOLOGY Epub ahead of print: -. 2014
• Patel Jayendra Z, Nevalainen Tapio J, Savinainen Juha R, Adams Yahaya, Laitinen Tuomo, Runyon Robert S, Vaara Miia, Ahenkorah Stephen, Kaczor Agnieszka A, Navia-Paldanius Dina, Gynther Mikko, Aaltonen Niina, Joharapurkar Amit A, Jain Mukul R, Haka Abigail S, Maxfield Frederick R, Laitinen Jarmo T, Parkkari Teija. 2014. Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. CHEMMEDCHEM 2015; 10 2: 253-265. 2014
• Parkkari Teija, Haavikko Raisa, Laitinen Tuomo, Navia-Paldanius Dina, Rytilahti Roosa, Vaara Miia, Lehtonen Marko, Alakurtti Sami, Yli-Kauhaluoma Jari, Nevalainen Tapio, Savinainen Juha R, Laitinen Jarmo T. 2014. Discovery of triterpenoids as reversible inhibitors of alpha/ß-hydrolase domain containing 12 (ABHD12). PLOS ONE [ONLINE] 9 5: e98286. 2014
• Lucchesi Valentina, Parkkari Teija, Savinainen Juha R, Malfitano Anna M, Allarà Marco, Bertini Simone, Castelli Francesca, Del Carlo Sara, Laezza Chiara, Ligresti Alessia, Saccomanni Giuseppe, Bifulco Maurizio, Di Marzo Vincenzo, Macchia Marco, Manera Clementina. 2014. 1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 74: 524-532. 2014
• Korhonen Jani, Kuusisto Anne, van Bruchem John, Patel Jayendra Z, Laitinen Tuomo, Navia-Paldanius Dina, Laitinen Jarmo T, Savinainen Juha R, Parkkari Teija, Nevalainen Tapio J. 2014. Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). BIOORGANIC AND MEDICINAL CHEMISTRY 22 23: 6694-6705. 2014
• Bertini Simone, Parkkari Teija, Savinainen Juha R, Arena Chiara, Saccomanni Giuseppe, Saguto Simone, Ligresti Alessia, Allarà Marco, Bruno Agostino, Marinelli Luciana, Di Marzo Vincenzo, Novellino Ettore, Manera Clementina, Macchia Marco. 2014. Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 90 (2015): 526-536. 2014
• Aaltonen Niina, Ribas Casandra R, Lehtonen Marko, Savinainen Juha R, Laitinen Jarmo T. 2013. Brain regional cannabinoid CB1 receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 2014:51: 87-95. 2013
• Aaltonen Niina, Savinainen Juha R, Ribas Casandra R, Rönkkö Jani, Kuusisto Anne, Korhonen Jani, Navia-Paldanius Dina, Häyrinen Jukka, Takabe Piia, Käsnänen Heikki, Pantsar Tatu, Laitinen Tuomo, Lehtonen Marko, Pasonen-Seppänen Sanna, Poso Antti, Nevalainen Tapio, Laitinen Jarmo T. 2013. Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase. CHEMISTRY AND BIOLOGY 20: 379-390. 2013
• Laitinen Tuomo, Navia-Paldanius Dina, Rytilahti Roosa, Marjamaa Joona J, Karizkova Julie, Parkkari Teija, Pantsar Tatu, Poso Antti, Laitinen Jarmo T, Savinainen Juha R. 2013. Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency. MOLECULAR PHARMACOLOGY 2014:85: 510-519. 2013
• Patel Jayendra Z, Parkkari Teija, Laitinen Tuomo, Kaczor Agnieszka A, Saario Susanna M, Savinainen Juha R, Navia-Paldanius Dina, Cipriano Mariateresa, Leppänen Jukka, Koshevoy Igor O, Poso Antti, Fowler Christopher J, Laitinen Jarmo T, Nevalainen Tapio. 2013. Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors. JOURNAL OF MEDICINAL CHEMISTRY 56: 8484-8496. 2013
• Navia-Paldanius D, Savinainen JR, Laitinen JT. 2012. Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12). JOURNAL OF LIPID RESEARCH 53: 2413-2424. 2012
• Savinainen JR, Saario SM, Laitinen JT. 2011. The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors ACTA PHYSIOLOGICA (OXFORD) 2012 vol 204 2: 267-276. 2011
• Savinainen JR, Megumi Y, Minkkilä A, Nevalainen T, & Laitinen JT. 2010. Characterization of binding properties of monoglyceride lipase inhibitors by a versatile fluorescene-based technique ANALYTICAL BIOCHEMISTRY 399: 132-134. 2010
• Minkkilä A, Savinainen JR, Käsnänen H, Xhaard H, Nevalainen T, Laitinen JT, Poso A, Leppänen J, Saario SM. 2009. Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors. CHEMMEDCHEM 4: 1253-1259. 2009
• Palomäki VAB, Lehtonen M, Savinainen JR, Laitinen JT. 2007. Visualization of 2-arachidonoylglycerol accumulation and cannabinoid CB1 receptor activity in rat brain cryosections by functional autoradiography. JOURNAL OF NEUROCHEMISTRY 101 4: 972-981. 2007
• Raitio KH, Savinainen JR, Nevalainen T, Järvinen T, Vepsäläinen J. 2006. Synthesis and in vitro evaluation of novel 2-oxo-1,2-dihydroquinoline CB2 receptor inverse agonists. CHEMICAL BIOLOGY AND DRUG DESIGN 68 6: 334-340. 2006
• Salo OMH, Savinainen JR, Parkkari T, Nevalainen T, Lahtela-Kakkonen M, Gynther J, Laitinen JT, Järvinen T, Poso A. 2006. 3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data JOURNAL OF MEDICINAL CHEMISTRY 49: 554-566. 2006
• Kokkola T, Savinainen JR, Mönkkönen KS, Retamal MD, Laitinen JT. 2005. S-Nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner BMC CELL BIOLOGY 6: 21. 2005
• Salo OMH, Raitio KH, Savinainen JR, Nevalainen T, Lahtela-Kakkonen M, Laitinen JT, Järvinen T, Poso A. 2005. Virtual screening of novel CB2 ligands using a comparative model of the human cannabinoid CB2 receptor JOURNAL OF MEDICINAL CHEMISTRY 48: 7166-7171. 2005
• Savinainen J. 2005. Optimized Methods to Determine Ligand Activities at the Cannabinoid CB1 and CB2 Receptors. Kuopion yliopiston julkaisuja C. Luonnontieteet ja ympäristötieteet. 2005
• Savinainen JR, Kokkola T, Salo OMH, Poso A, Järvinen T, Laitinen JT. 2005. Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor. BRITISH JOURNAL OF PHARMACOLOGY 145: 636-645. 2005
• Parkkari T, Savinainen JR, Rauhala AL, Tolonen TL, Nevalainen T, Laitinen JT, Gynther J, Järvinen T. 2004. Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS 14: 3231-3234. 2004
• Saario SM, Savinainen JR, Laitinen JT, Järvinen T, Niemi R. 2004. Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes. BIOCHEMICAL PHARMACOLOGY 67: 1381-1387. 2004
• Savinainen JR, Laitinen JT. 2004. Detection of cannabinoid CB1, adenosine A1, muscarinic acetylcholine, and GABAB receptor-dependent G protein activity in transducin-deactivated membranes and autoradiography sections of rat retina. CELLULAR AND MOLECULAR NEUROBIOLOGY 24 2: 243-256. 2004