
JUHA SAVINAINEN
Senior Researcher
Contact info
Organization
School of Medicine, Biomedicine
juha.savinainen@uef.fi
Phone
+358 40 355 3696
Keywords
Research groups and research projects
By combining the expertise represented by our collaborators in the fields of synthetic chemistry and metabolomics, our group aims at deeper molecular level understanding on the key players orchestrating lipid signaling in health and disease. Our current efforts focus specifically on the mechanisms of migraine and other pain conditions.
Funding: Migraine Research Foundation, https://migraineresearchfoundation.org/
Collaboration: Prof. Rashid Giniatullin (AIVI, UEF), Prof. Christina Tassorelli (University of Pavia, Italy), Prof. Petteri Nieminen (UEF), Prof. Antti Poso (UEF), Dos. Tuomo Laitinen (UEF), Dos. Marko Lehtonen (UEF), Dos. Tapio Nevalainen (UEF), Dr. Muneer Ahamed (University of Queensland, Australia), Dr. Jayendra Patel (University of Helsinki), Dos. Jarmo T. Laitinen (UEF), MSci. Prosanta Singha (UEF), Prof. Anna-Liisa Levonen (UEF)
Research groups - UEF
Publications
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Della Pietra, Adriana; Giniatullin, Rashid; Savinainen, Juha R. 2021. Distinct Activity of Endocannabinoid-Hydrolyzing Enzymes MAGL and FAAH in Key Regions of Peripheral and Central Nervous System Implicated in Migraine International journal of molecular sciences 22 3: 1204. 2021
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Aaltonen, Niina; Singha, Prosanta; Jakupovic, Hermina; Wirth, Thomas; Samaranayake, Haritha; Pasonen-Seppänen, Sanna; Rilla, Kirsi; Varjosalo, Markku; Edgington-Mitchell, Laura; Kasperkiewicz, Paulina; Drag, Marcin; Kälvälä, Sara; Moisio, Eemeli; Savinainen, Juha; Laitinen, Jarmo. 2020. High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils Biological procedures online 22: 6. 2020
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Grimsey, NL; Savinainen, JR; Attili, B; Ahamed, M. 2020. Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications Drug discovery today 25 2: 330-343. 2020
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Singha, Prosanta; Mäklin, Kiira; Vihavainen, Taina; Laitinen, Tuomo; Nevalainen, Tapio; Patil, Mahadeo; Tonduru, Arun; Poso, Antti; Laitinen, Jarmo; Savinainen, Juha. 2020. Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells European journal of pharmaceutical sciences 149: 105321. 2020
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Ahonen, Tiina J; Savinainen, Juha R; Yli-Kauhaluoma, Jari: Kalso, Eija; Laitinen, Jarmo T; Moreira, Vânia M. 2018. Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A ACS Medicinal Chemistry Letters 9 12: 1269-1273. 2018
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Ahamed Muneer, Attili Bala, van Veghel Daisy, Ooms Maarten, Berben Philippe, Celen Sofie, Koole Michel, Declercq Lieven, Savinainen Juha R, Laitinen Jarmo T, Verbruggen Alfons, Bormans Guy. 2017. Synthesis and preclinical evaluation of [11C]MA-PB-1 for in vivo imaging of brain monoacylglycerol lipase (MAGL). EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 136: 104-113. 2017
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Pantsar T, Singha P, Nevalainen TJ, Koshevoy I, Leppänen J, Poso A, Niskanen JMA, Pasonen-Seppänen S, Savinainen JR, Laitinen T, Laitinen JT. 2017. Design, Synthesis, and Biological Evaluation of 2,4-Dihydropyrano[2,3-c]pyrazole Derivatives as Autotaxin Inhibitors. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 107: 97-111. 2017
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Savinainen Juha R, Navia-Paldanius Dina, Laitinen Jarmo T. 2016. A sensitive and versatile fluorescent activity assay for ABHD6. In: Maccarrone Mauro (ed.) Endocannabinoid Signaling: Methods and Protocols. Springer. Methods in Molecular Biology 1412. s. 169-178. 2016
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Savinainen Juha R, Navia-Paldanius Dina, Laitinen Jarmo T. 2016. A sensitive and versatile fluorescent activity assay for ABHD12. In: Maccarrone Mauro (ed.) Endocannabinoid Signaling: Methods and Protocols. Springer. Methods in Molecular Biology 1412. s. 179-189. 2016
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Navia-Paldanius D, Patel JZ, López Navarro M, Jakupovic H, Goffart S, Pasonen-Seppänen S, Nevalainen TJ, Jääskeläinen T, Laitinen T, Laitinen JT, Savinainen JR. 2016. Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alfa/beta-hydrolase domain containing 11 (ABHD11). EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 93: 253-263. 2016