Kai Kaarniranta

A New Generation of Gene Therapies as the Future of Wet AMD Treatment

Blasiak, Janusz; Pawlowska, Elzbieta; Ciupińska, Justyna; Derwich, Marcin; Szczepanska, Joanna; Kaarniranta, Kai. 2024. International journal of molecular sciences. 25:

Acta Ophthalmologica 100 years-Overview of selected articles during Acta Ophthalmologica history

Kaarniranta, Kai; Pawlikowska-Lagod, Katarzyna; Jääskeläinen, Juha E; Grzybowski, Andrzej E. 2024. Acta ophthalmologica. 102: 367-373

Analysis of prognostic and predictive factors in neovascular age-related macular degeneration Kuopio cohort

Heloterä, Hanna; Siintamo, Leea; Kivinen, Niko; Abrahamsson, Nicholas; Aaltonen, Vesa; Kaarniranta, Kai. 2024. Acta ophthalmologica. [Epub ahead of print 10 April 2024]: 1-11

Konsensusehdotukset dosentin arvon myöntämiseen liittyvistä käytänteistä ja näkökulmista

Axelin, Anna; Heikinheimo, Markku; Heistaro, Sami; Kaarniranta, Kai; Kähönen, Mika; Lehenkari, Petri; Parkkila, Seppo; Rautalahti, Matti; Riipinen, Pirkko; Rämet, Mika; Saharinen, Pipsa; Toppari, Jorma; Vainionpää, Anne. 2024. Duodecim. 140: 77-82

PGC‐1α regulates the interplay between oxidative stress, senescence and autophagy in the ageing retina important in age‐related macular degeneration

Gurubaran, Iswariyaraja Sridevi; Watala, Cezary; Kostanek, Joanna; Szczepanska, Joanna; Pawlowska, Elzbieta; Kaarniranta, Kai; Blasiak, Janusz. 2024. Journal of cellular and molecular medicine. 28: 1-13

Silmänpohjan ikärappeuman esiintyminen ja hoitomahdollisuudet

Purola, Petri; Kaarniranta, Kai; Uusitalo, Hannu. 2024. Duodecim. 140: 215-222

The incidence and prevalence of diabetic macular edema and proliferative diabetic retinopathy, their progression to visual impairment and patterns in their intravitreal treatment in the Finnish population

Heloterä, Hanna; Arffman, Martti; Sund, Reijo; Keskimäki, Ilmo; Kaarniranta, Kai. 2024. Acta ophthalmologica. [First published: 24 March 2024]: 1-10

Tissue fibroblasts are versatile immune regulators: An evaluation of their impact on the aging process

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2024. Ageing research reviews. 97:

Acta Ophthalmologica for 100 years

Kaarniranta, Kai; Stefansson, Einar. 2023. Acta ophthalmologica. 101: 7

Association of APOE Haplotypes With Common Age-Related Ocular Diseases in 412,171 Individuals

Liuska, Perttu J; Rämö, Joel T; Lemmelä, Susanna; Kaarniranta, Kai; Uusitalo, Hannu; Lahtela, Elisa; Daly, Mark J; Harju, Mika; Palotie, Aarno; Turunen, Joni A. 2023. Investigative ophthalmology and visual science. 64:

Cis-urocanic acid improves cell viability and suppresses inflammasome activation in human retinal pigment epithelial cells

Korhonen, Eveliina; Piippo, Niina; Hytti, Maria; Kaarniranta, Kai; Kauppinen, Anu. 2023. Biochemical pharmacology. 216:

Comparison of barrier properties of outer blood-retinal barrier models - Human stem cell-based models as a novel tool for ocular drug discovery

Hellinen, Laura; Hongisto, Heidi; Ramsay, Eva; Kaarniranta, Kai; Vellonen, Kati-Sisko; Skottman, Heli; Ruponen, Marika. 2023. European journal of pharmaceutics and biopharmaceutics. 184: 181-188

Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients

Karema-Jokinen, Viivi; Koskela, Ali; Hytti, Maria; Hongisto, Heidi; Viheriälä, Taina; Liukkonen, Mikko; Torsti, Tommi; Skottman, Heli; Kauppinen, Anu; Nymark, Soile; Kaarniranta, Kai. 2023. Journal of biological chemistry. 299:

Epigallocatechin-3-Gallate, an Active Green Tea Component to Support Anti-VEGFA Therapy in Wet Age-Related Macular Degeneration

Blasiak, Janusz; Chojnacki, Jan; Szczepanska, Joanna; Fila, Michal; Chojnacki, Cezary; Kaarniranta, Kai; Pawlowska, Elzbieta. 2023. Nutrients. 15:

Extracellular vesicles in degenerative retinal diseases: A new therapeutic paradigm

Manai, Federico; Smedowski, Adrian; Kaarniranta, Kai; Comincini, Sergio; Amadio, Marialaura. 2023. Journal of controlled release. 2024; 365: 448-468

Non-Coding RNAs Regulating Mitochondrial Functions and the Oxidative Stress Response as Putative Targets against Age-Related Macular Degeneration (AMD)

Hyttinen, Juha MT; Blasiak, Janusz; Kaarniranta, Kai. 2023. International journal of molecular sciences. 24:

Overlap of Genetic Loci for Central Serous Chorioretinopathy With Age-Related Macular Degeneration

Rämö, Joel T.; Abner, Erik; van Dijk, Elon HC; Wang, Xin; Brinks, Joost; Nikopensius, Tiit; Nõukas, Margit; Marjonen, Heidi; Silander, Kaisa; Jukarainen, Sakari; Kiiskinen, Tuomo; Choi, Seung Hoan; Kajanne, Risto; Mehtonen, Juha; Palta, Priit; Lubitz, Steven A.; Kaarniranta, Kai; Sobrin, Lucia; Kurki, Mitja; Yzer, Suzanne; Ellinor, Patrick T; Esko, Tõnu; Daly, Mark J; den Hollander, Anneke I; Palotie, Aarno; Turunen, Joni A.; Boon, Camiel JF; Rossin, Elizabeth J; for the FinnGen Study; for the E. 2023. JAMA ophthalmology. 141: 449-457

Oxidative Stress and Cellular Protein Accumulation Are Present in Keratoconus, Macular Corneal Dystrophy, and Fuchs Endothelial Corneal Dystrophy

Vottonen, Linda; Koskela, Ali; Felszeghy, Szabolcs; Wylegala, Adam; Kryszan, Katarzyna; Gurubaran, Iswariyaraja Sridevi; Kaarniranta, Kai; Wylegala, Edward. 2023. Journal of clinical medicine. 12:

The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance

Toppila, Maija; Hytti, Maria; Korhonen, Eveliina; Ranta-aho, Sofia; Harju, Niina; Forsberg, Markus M.; Kaarniranta, Kai; Jalkanen, Aaro; Kauppinen, Anu. 2023. Antioxidants. 12:

A Linkage between Angiogenesis and Inflammation in Neovascular Age-Related Macular Degeneration

Heloterä, Hanna; Kaarniranta, Kai. 2022. Cells. 11:

Acta Ophthalmologica 2021

Kaarniranta, Kai; Stefánsson, Einar. 2022. Acta ophthalmologica. 100: 483-485

Ajokorttitodistusten näkövaatimukset

Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 680. Kustannus Oy Duodecim

Angioid streak

Kaarniranta, Kai; Uusitalo-Järvinen, Hannele. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 272-273. Kustannus Oy Duodecim

Autophagy in age-related macular degeneration

Kaarniranta, Kai; Blasiak, Janusz; Liton, Paloma; Boulton, Michael; Klionsky, Daniel J.; Sinha, Debasish. 2022. Autophagy. 2023; 19: 388-400

Bestin tauti

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 265. Kustannus Oy Duodecim

Brolusitsumabi

Kaarniranta, Kai; Kajander, Maria. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 773. Kustannus Oy Duodecim

Computer-based Eye-tracking Analysis of King-Devick Test Differentiates Persons With Idiopathic Normal Pressure Hydrocephalus From Cognitively Unimpaired

Lehtola, Juha-Matti; Kärkkäinen, Virve; Andberg, Sami; Hannonen, Sanna; Rusanen, Minna; Saari, Toni; Korhonen, Ville; Hokkanen, Laura; Hallikainen, Merja; Hänninen, Tuomo; Kaarniranta, Kai; Bednarik, Roman; Leinonen, Ville; Koivisto, Anne M. 2022. Alzheimer disease and associated disorders. 36: 340-346

Epidemia-ajan erityistoimet silmäpotilailla

Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 67-68. Kustannus Oy Duodecim

Epidemia-ajan kiireellinen ja kiireetön hoito silmätaudeilla

Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 59-66. Kustannus Oy Duodecim

Epoxomicin, a Selective Proteasome Inhibitor, Activates AIM2 Inflammasome in Human Retinal Pigment Epithelium Cells

Sridevi Gurubaran, Iswariyaraja; Hytti, Maria; Kaarniranta, Kai; Kauppinen, Anu. 2022. Antioxidants. 11:

Etukammionäytteen ja lasiaisnäytteen otto

Kaarniranta, Kai; Marttila, Liisa; Seppänen, Matti. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 631. Kustannus Oy Duodecim

Fluoreseiiniangiografia (FAG)

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 579-580. Kustannus Oy Duodecim

Fotodynaaminen hoito (PDT)

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 657. Kustannus Oy Duodecim

Hormetic Heat Shock Enhances Autophagy through HSF1 in Retinal Pigment Epithelium Cells

Amirkavei, Mooud; Plastino, Flavia; Kvanta, Anders; Kaarniranta, Kai; André, Helder; Koskelainen, Ari. 2022. Cells. 11:

Hydroquinone increases risk for retinal pigment epithelial (RPE) cell degeneration

Bhattarai, Niina; Hytti, Maria; Mysore, Yashavanthi; Kaarniranta, Kai; Kauppinen, Anu. 2022. Acta ophthalmologica

Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions

Bhattarai, Niina; Hytti, Maria; Reinisalo, Mika; Kaarniranta, Kai; Mysore, Yashavanthi; Kauppinen, Anu. 2022. Immunologic research. 70: 678-687

Incidence of cataract surgeries in relation to diagnosis of Parkinson's disease

Lampela, Pasi; Tolppanen, Anna-Maija; Kaarniranta, Kai; Hokkinen, Kaisa; Hartikainen, Sirpa. 2022. Archives of gerontology and geriatrics. 2023; 104:

Indosyaaniinivihreä

Kivinen, Niko; Kaarniranta, Kai; Kajander, Maria. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 766-767. Kustannus Oy Duodecim

Interplay between aging and other factors of the pathogenesis of age-related macular degeneration

Blasiak, Janusz; Sobczuk, Piotr; Pawlowska, Elzbieta; Kaarniranta, Kai. 2022. Ageing research reviews. 81:

Ketotifeeni

Marttila, Liisa; Kivinen, Niko; Kaarniranta, Kai; Seppänen, Matti; Kaustiala, Klaudia. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 755. Kustannus Oy Duodecim

Lasiaisinjektion toteutus

Kaarniranta, Kai; Seppänen, Matti. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 704-. Kustannus Oy Duodecim

Leikkauksenjälkeinen silmämunan sisäosien yleistulehdus

Kaarniranta, Kai; Marttila, Liisa; Seppänen, Matti. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 211-215. Kustannus Oy Duodecim

Microglia–Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model

Boyce, Maeve; Xin, Ying; Chowdhury, Olivia; Shang, Peng; Liu, Haitao; Koontz, Victoria; Strizhakova, Anastasia; Nemani, Mihir; Hose, Stacey; Zigler, J. Samuel; Campbell, Matthew; Sinha, Debasish; Handa, James T.; Kaarniranta, Kai; Qian, Jiang; Ghosh, Sayan. 2022. Cells. 11:

Mikrobinäytteen otto silmästä

Kaarniranta, Kai, Setälä, Niko. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 627-629. Kustannus Oy Duodecim

Myooppinen degeneraatio

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 264-265. Kustannus Oy Duodecim

Nature-Inspired Hybrids (NIH) Improve Proteostasis by Activating Nrf2-Mediated Protective Pathways in Retinal Pigment Epithelial Cells

Koskela, Ali; Manai, Federico; Basagni, Filippo; Liukkonen, Mikko; Rosini, Michela; Govoni, Stefano; Monte, Massimo Dal; Smedowski, Adrian; Kaarniranta, Kai; Amadio, Marialaura. 2022. Antioxidants. 11: . 1385

Optic pit -makulopatia

Kaarniranta, Kai; Seppänen, Matti. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 385-386. Kustannus Oy Duodecim

Optinen valokerroskuvaus (OCT)

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 583-594. Kustannus Oy Duodecim

Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2022. Inflammation research. 71: 817-831

Polyyppimainen suonikalvoston rappeuma

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 260. Kustannus Oy Duodecim

Ravistellun vauvan oireyhtymä

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 523-524. Kustannus Oy Duodecim

Retraction: Hellinen et al. Drug Flux across RPE Cell Models: The Hunt for an Appropriate Outer Blood–Retinal Barrier Model for Use in Early Drug Discovery. Pharmaceutics 2020, 12, 176

Hellinen, Laura; Hongisto, Heidi; Ramsay, Eva; Kaarniranta, Kai; Vellonen, Kati-Sisko; Skottman, Heli; Ruponen, Marika. 2022. Pharmaceutics. 14: 595

Secretory autophagy: a turn key for understanding AMD pathology and developing new therapeutic targets?

Blasiak, Janusz; Kaarniranta, Kai. 2022. Expert opinion on therapeutic targets. 26: 883-895

Shortening of Saccades as a Possible Easy-to-Use Biomarker to Detect Risk of Alzheimer’s Disease

Hannonen, Sanna; Andberg, Sami; Kärkkäinen, Virve; Rusanen, Minna; Lehtola, Juha-Matti; Saari, Toni; Korhonen, Ville; Hokkanen, Laura; Hallikainen, Merja; Hänninen, Tuomo; Leinonen, Ville; Kaarniranta, Kai; Bednarik, Roman; Koivisto, Anne M.. 2022. Journal of Alzheimer's disease. 88: 609-618

Siklosporiini

Seppänen, Matti; Kaarniranta, Kai; Kajander, Maria. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 777-778. Kustannus Oy Duodecim

Silmälääkkeet ja niiden vaikutukset

Hautala, Nina; Kaarniranta, Kai; Uusitalo, Hannu. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 699-702. Kustannus Oy Duodecim

Silmänpohjan ikärappeumat

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 257-259. Kustannus Oy Duodecim

Silmänvärve (nystagmus)

Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 395. Kustannus Oy Duodecim

Silmätautien käsikirja

Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. 2022. . 3., uudistettu painos. Kustannus Oy Duodecim

Sisäsyntyisen silmämunan sisäosien tulehdus

Marttila, Liisa; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 215-216. Kustannus Oy Duodecim

Stargardtin tauti/Fundus flavimaculatus

Kaarniranta, Kai; Seppänen, Matti. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 266-267. Kustannus Oy Duodecim

Telangiekstasiat

Kaarniranta, Kai; Setälä, Niko. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 273-274. Kustannus Oy Duodecim

The Effect of Dietary Supplementations on Delaying the Progression of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis

Csader, Susanne; Korhonen, Sonja; Kaarniranta, Kai; Schwab, Ursula. 2022. Nutrients. 14:

Topical treatment of diabetic macular edema using dexamethasone ophthalmic suspension: A randomized, double‐masked, vehicle‐controlled study

Stefansson, Einar; Loftsson, Thorstein; Larsen, Michael; Papp, András; Kaarniranta, Kai; Munk, Marion R.; Dugel, Pravin; Tadayoni, Ramin. 2022. Acta ophthalmologica. 2023; 101: 22-33

Valsalva retinopatia

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 276. Kustannus Oy Duodecim

Verkkokalvo-oksimetri

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 583. Kustannus Oy Duodecim

Verkkokalvohalkio

Kaarniranta, Kai; Marttila, Liisa. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 281-282. Kustannus Oy Duodecim

Verkkokalvon angiomaattinen proliferaatio

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 261-262. Kustannus Oy Duodecim

Verkkokalvon keskeinen nesteirtauma

Kivinen, Niko; Kaarniranta, Kai; Seppänen Matti. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 262-264. Kustannus Oy Duodecim

Verkkokalvon makroaneurysma

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 274-275. Kustannus Oy Duodecim

Verkkokalvon reunaosien rappeumat

Marttila, Liisa, Kaarniranta, Kai . Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 282-284. Kustannus Oy Duodecim

Visual impairment due to age‐related macular degeneration during 40 years in Finland and the impact of novel therapies

Purola, Petri; Kaarniranta, Kai; Ojamo, Matti; Gissler, Mika; Uusitalo, Hannu. 2022. Acta ophthalmologica. 2023; 101: 57-64

Antimycin A-induced mitochondrial dysfunction regulates inflammasome signaling in human retinal pigment epithelial cells

Korhonen, Eveliina; Hytti, Maria; Piippo, Niina; Kaarniranta, Kai; Kauppinen, Anu. 2021. Experimental eye research. 209: 108687

Association of the MYOC p.(Gln368Ter) Variant With Glaucoma in a Finnish Population

Liuska, PJ; Lemmelä, S; Havulinna, AS; Kaarniranta, K; Uusitalo, H; Laivuori, H; Kiiskinen, T; Daly, MJ; Palotie, A; Turunen, JA. 2021. JAMA ophthalmology. 139: 762-768

Differential Expression of Inflammasome-Related Genes in Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells with or without History of Age-Related Macular Degeneration

Hytti, Maria; Korhonen, Eveliina; Hongisto, Heidi; Kaarniranta, Kai; Skottman, Heli; Kauppinen, Anu. 2021. International journal of molecular sciences. 22: 6800

Dysregulated Tear Film Proteins in Macular Edema Due to the Neovascular Age-Related Macular Degeneration Are Involved in the Regulation of Protein Clearance, Inflammation, and Neovascularization

Winiarczyk, Mateusz; Winiarczyk, Dagmara; Michalak, Katarzyna; Kaarniranta, Kai; Adaszek, Lukasz; Winiarczyk, Stanislaw; Mackiewicz, Jerzy. 2021. Journal of clinical medicine. 10: 3060

Effect of cataract surgery on wet age-related macular degeneration activity

Karesvuo, Petteri; Elbaz, Uri; Achiron, Asaf; Hecht, Idan; Kaarniranta, Kai; Tuuminen, Raimo. 2021. Acta ophthalmologica. 2022; 100: e262-e269

Effects of Resvega on Inflammasome Activation in Conjunction with Dysfunctional Intracellular Clearance in Retinal Pigment Epithelial (RPE) Cells

Bhattarai, Niina; Piippo, Niina; Ranta-aho, Sofia; Mysore, Yashavanthi; Kaarniranta, Kai; Kauppinen, Anu. 2021. Antioxidants. 10: 67

Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice

Blasiak, Janusz; Koskela, Ali; Pawlowska, Elzbieta; Liukkonen, Mikko; Ruuth, Johanna; Toropainen, Elisa; Hyttinen, Juha MT; Viiri, Johanna; Eriksson, John E.; Xu, Heping; Chen, Mei; Felszeghy, Szabolcs; Kaarniranta, Kai. 2021. International journal of molecular sciences. 22: 1684

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Klionsky, Daniel J; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; Abildgaard, Marie H; Abudu, Yakubu Princely; Acevedo-Arozena, Abraham; Adamopoulos, Iannis E; Adeli, Khosrow; Adolph, Timon E; Adornetto, Annagrazia; Aflaki, Elma; Agam, Galila; Agarwal, Anupam; Aggarwal, Bharat B; Agnello, Maria; Agostinis, Patrizia et al. [Incl. Haapasalo, Annakaisa; Leskelä, Stina; Kaarniranta, Kai; Kauppinen, Anu; Koskela, Ali]. 2021. Autophagy. 17: 1-382

Hydroquinone Induces NLRP3-Independent IL-18 Release from ARPE-19 Cells

Bhattarai, Niina; Korhonen, Eveliina; Mysore, Yashavanthi; Kaarniranta, Kai; Kauppinen, Anu. 2021. Cells. 10: 1405

Hypoxia/ischemia impairs CD33 (Siglec-3)/TREM2 signaling: Potential role in Alzheimer's pathogenesis

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2021. Neurochemistry international. 150: 105186

Incidence of cataract surgeries in people with and without Alzheimer's disease

Hokkinen, K; Kaarniranta, K; Jämsen, E; Lampela, P; Hartikainen, S; Tolppanen, AM. 2021. Acta ophthalmologica. 2022; 100: 68-73

Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Hellinen, Laura; Koskela, Ali; Vattulainen, Elina; Liukkonen, Mikko; Wegler, Christine; Treyer, Andrea; Handin, Niklas; Svensson, Richard; Myöhänen, Timo; Poso, Antti; Kaarniranta, Kai; Artursson, Per; Urtti, Arto. 2021. Biomedicine and pharmacotherapy. 2022; 146: 112501

Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2021. Inflammation research. 70: 1043-1061

Lasiaisinjektiot mullistivat silmänpohjan kostean ikärappeuman hoidon

Kivinen, Niko; Kaarniranta, Kai. 2021. Lääkärilehti. 76: 2055-2058

MicroRNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy

Hyttinen, Juha M T; Blasiak, Janusz; Felszeghy, Szabolcs; Kaarniranta, Kai. 2021. Ageing research reviews. 67: 101260

Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1[alpha] -/- Mouse Model Evoke Complement Component C5a Independent of C3

Sridevi Gurubaran, Iswariyaraja; Heloterä, Hanna; Marry, Stephen; Koskela, Ali; Hyttinen, Juha MT; Paterno, Jussi J; Urtti, Arto; Chen, Mei; Xu, Heping; Kauppinen, Anu; Kaarniranta, Kai. 2021. Biology. 10: 622

Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice

Tamminen, Toni; Koskela, Ali; Toropainen, Elisa; Gurubaran, Iswariyaraja Sridevi; Winiarczyk, Mateusz; Liukkonen, Mikko; Paterno, Jussi J; Lackman, Petri; Sadeghi, Amir; Viiri, Johanna; Hyttinen, Juha MT; Koskelainen, Ari; Kaarniranta, Kai. 2021. Oxidative medicine and cellular longevity. 2021:

Potential of Long Non-Coding RNAs in Age-Related Macular Degeneration

Blasiak, Janusz; Hyttinen, Juha M. T.; Szczepanska, Joanna; Pawlowska, Elzbieta; Kaarniranta, Kai. 2021. International journal of molecular sciences. 22: 9178

Potential of Telomerase in Age-Related Macular Degeneration-Involvement of Senescence, DNA Damage Response and Autophagy and a Key Role of PGC-1α

Blasiak, J; Szczepanska, J; Fila, M; Pawlowska, E; Kaarniranta, K. 2021. International journal of molecular sciences. 22: 7194

Serum Levels of Plasmalogens and Fatty Acid Metabolites Associate with Retinal Microangiopathy in Participants from the Finnish Diabetes Prevention Study

de Mello, Vanessa Derenji; Selander, Tuomas; Lindström, Jaana; Tuomilehto, Jaakko; Uusitupa, Matti; Kaarniranta, Kai. 2021. Nutrients. 13: 4452

Successful years of collaboration between Acta Ophthalmologica and the European Association for Vision and Eye Research

Kaarniranta, Kai; Stefansson, Einar. 2021. Acta ophthalmologica. 99: 239

TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells

Ranta-aho, Sofia; Piippo, Niina; Korhonen, Eveliina; Kaarniranta, Kai; Hytti, Maria; Kauppinen, Anu. 2021. International journal of molecular sciences. 22: 4875

The most successful year in the history of Acta Ophthalmologica

Kaarniranta, Kai; Stefánsson, Einar. 2021. Acta ophthalmologica. 99: 117-117

The state of your journal Acta Ophthalmologica 2020

Kaarniranta, Kai; Stefánsson, Einar. 2021. Acta ophthalmologica. 99: 467-469

Therapeutic potential of PGC-1α in age-related macular degeneration (AMD) - the involvement of mitochondrial quality control, autophagy, and antioxidant response

Hyttinen, Juha; Blasiak, Janusz; Tavi, Pasi; Kaarniranta, Kai. 2021. Expert opinion on therapeutic targets. 25: 773-785

Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application

Rousou, Charis; Schuurmans, Carl C. L.; Urtti, Arto; Mastrobattista, Enrico; Storm, Gert; Moonen, Chrit; Kaarniranta, Kai; Deckers, Roel. 2021. Pharmaceutics. 13: 1782

Autophagy Genes for Wet Age-Related Macular Degeneration in a Finnish Case-Control Study

Paterno, Jussi J; Koskela, Ali; Hyttinen, Juha M T; Vattulainen, Elina; Synowiec, Ewelina; Tuuminen, Raimo; Watala, Cezary; Blasiak, Janusz; Kaarniranta, Kai. 2020. Genes. 11: 1318

Comparison of Two Different Treat-and-Extend Protocols with Afibercept in Wet Age-Related Macular Degeneration: Two-Year Results

Taipale, Claudia; Lindholm, Juha-Matti; Kaarniranta, Kai; Tuuminen, Raimo. 2020. Advances in therapy. 37: 2256-2266

Correlation Between the Rate of Intravitreal Injections, Use of Aflibercept as a Second-Line Treatment and Visual Impairment for Wet AMD in Finland

Karesvuo, Petteri; Hakkala, Laura; Kaarniranta, Kai; Uusitalo, Hannu; Ojamo, Matti; Tuuminen, Raimo. 2020. Acta ophthalmologica. 98: 472-476

DICER1 in the Pathogenesis of Age-related Macular Degeneration (AMD) - Alu RNA Accumulation versus miRNA Dysregulation

Kaarniranta, Kai; Pawlowska, Elzbieta; Szczepanska, Joanna; Blasiak, Janusz. 2020. Aging and disease. 11: 851-862

Drug Flux Across RPE Cell Models: The Hunt for An Appropriate Outer Blood-Retinal Barrier Model for Use in Early Drug Discovery

Hellinen, Laura; Hongisto, Heidi; Ramsay, Eva; Kaarniranta, Kai; Vellonen, Kati-Sisko; Skottman, Heli; Ruponen, Marika. 2020. Pharmaceutics. 12: 176

ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2020. Journal of molecular medicine: jmm. 98: 633-650

Exosomal vesicles enhance immunosuppression in chronic inflammation: Impact in cellular senescence and the aging process

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2020. Cellular signalling. 75: 109771

Immunological biomarkers of the vitreous responsible for proliferative alteration in the different forms of retinal detachment

Balogh, Anikó; Milibák, Tibor; Szabó, Viktória; Nagy, Zoltán Zsolt; Kaarniranta, Kai; Resch, Miklós D. 2020. Bmc ophthalmology. 20: 491

In vitro stem cell modelling demonstrates a proof-of-concept for excess functional mutant TIMP3 as the cause of Sorsby Fundus Dystrophy

Hongisto, H; Dewing, JM; Christensen, DRG; Scott, J; Cree, AJ; Nättinen, J; Määttä, J; Jylhä, A; Aapola, U; Uusitalo, H; Kaarniranta, K; Ratnayaka, JA; Skottman, H; Lotery, AJ. 2020. Journal of pathology. 252: 138-150

Induction of Heat Shock Protein 70 in Mouse RPE as an In Vivo Model of Transpupillary Thermal Stimulation

Amirkavei, Mooud; Pitkänen, Marja; Kaikkonen, Ossi; Kaarniranta, Kai; André, Helder; Koskelainen, Ari. 2020. International journal of molecular sciences. 21: 2063

Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration

Kaarniranta, Kai; Uusitalo, Hannu; Blasiak, Janusz; Felszeghy, Szabolcs; Kannan, Ram; Kauppinen, Anu; Salminen, Antero; Sinha, Debasish; Ferrington, Deborah. 2020. Progress in retinal and eye research. 78: 100858

Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model

Sridevi Gurubaran, Iswariyaraja; Viiri, Johanna; Koskela, Ali; Hyttinen, Juha M; Paterno, Jussi; Kis, Gréta; Antal, Miklós; Urtti, Arto; Kauppinen, Anu; Felszeghy, Szabolcs; Kaarniranta, Kai. 2020. International journal of molecular sciences. 21: 1976

Only IL-1ß release is inflammasome-dependent upon ultraviolet B irradiation although IL-18 is also secreted

Korhonen, Eveliina; Piippo, Niina; Hytti, Maria; Hyttinen, Juha; Kaarniranta, Kai; Kauppinen, Anu. 2020. Faseb journal. 34: 6437-6448

Potential Role of Myeloid-Derived Suppressor Cells (MDSCs) in Age-Related Macular Degeneration (AMD)

Kauppinen, Anu; Kaarniranta, Kai; Salminen, Antero. 2020. Frontiers in immunology. 11: 384

Resvega Alleviates Hydroquinone-Induced Oxidative Stress in ARPE-19 Cells

Bhattarai, Niina; Korhonen, Eveliina; Toppila, Maija; Koskela, Ali; Kaarniranta, Kai; Mysore, Yashavanthi; Kauppinen, Anu. 2020. International journal of molecular sciences. 21: 2066

Resveratrol as Inducer of Autophagy, Pro-Survival, and Anti-Inflammatory Stimuli in Cultured Human RPE Cells

Josifovska, N; Albert, R; Nagymihály, R; Lytvynchuk, L; Moe, MC; Kaarniranta, K; Veréb, ZJ; Petrovski, G. 2020. International journal of molecular sciences. 21: 813

The Aging Stress Response and Its Implication for AMD Pathogenesis

Blasiak, Janusz; Pawlowska, Elzbieta; Sobczuk, Anna; Szczepanska, Joanna; Kaarniranta, Kai. 2020. International journal of molecular sciences. 21: 8840

The role of vision-related problems in fatal road accidents in Finland

Wedenoja, Juho; Kalsi, Juhani; Salenius, Salla; Parkkari, Kalle; Kaarniranta, Kai; Tervo, Timo. 2020. Acta ophthalmologica. 2021; 99: 427-430

Trehalose for Ocular Surface Health

Laihia, Jarmo; Kaarniranta, Kai. 2020. Biomolecules. 10: 809

UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells

Korhonen, Eveliina; Bisevac, Jovana; Hyttinen, Juha MT; Piippo, Niina; Hytti, Maria; Kaarniranta, Kai; Petrovski, Goran; Kauppinen, Anu. 2020. Investigative ophthalmology and visual science. 61: 7

Yhtenäiset vaatimukset lääketieteen ja hammaslääketieteen tohtorintutkinnolle Suomessa

Lehenkari, Petri; Tuovinen, Timo; Alahuhta, Seppo; Risteli, Leila; Ylöstalo, Pekka; Rämet, Mika; Parkkila, Seppo; Happo, Saara; Kaarniranta, Kai; Blom, Nina; Ritvos, Olli; Kähäri, Veli-Matti; Leivo, Ilmo; Heikinheimo, Markku. 2020. Duodecim. 136: 633-640

Zinc and Autophagy in Age-Related Macular Degeneration

Blasiak, Janusz; Pawlowska, Elzbieta; Chojnacki, Jan; Szczepanska, Joanna; Chojnacki, Cezary; Kaarniranta, Kai. 2020. International journal of molecular sciences. 21: 4994

AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging

Salminen, Antero; Kauppinen, Anu; Kaarniranta, Kai. 2019. Journal of molecular medicine: jmm. 97: 1049-1064

Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy

Hytti, Maria; Korhonen, Eveliina; Hyttinen, Juha M T; Roehrich, Heidi; Kaarniranta, Kai; Ferrington, Deborah A; Kauppinen, Anu. 2019. Oxidative medicine and cellular longevity. 2019: 1583656

Can vitamin D protect against age-related macular degeneration or slow its progression?

Kaarniranta, K; Pawlowska, E; Szczepanska, J; Jablkowska, A; Blasiak, J. 2019. Acta biochimica polonica. 66: 147-158

Changes in ocular signs and symptoms in patients switching from bimatoprost-timolol to tafluprost-timolol eye drops: an open-label phase IV study

Bourne, RRA; Kaarniranta, K; Lorenz, K; Traverso, CE; Vuorinen, J; Ropo, A. 2019. BMJ open. 9: e024129

Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients

Kiamehr, M; Klettner, A; Richert, E; Koskela, A; Koistinen, A; Skottman, H; Kaarniranta, K; Aalto-Setälä, K; Juuti-Uusitalo, K. 2019. International journal of molecular sciences. 20: 3773

Dietary Polyphenols in Age-Related Macular Degeneration: Protection against Oxidative Stress and Beyond

Pawlowska, E; Szczepanska, J; Koskela, A; Kaarniranta, K; Blasiak, J. 2019. Oxidative medicine and cellular longevity. 2019: 9682318

Disease aetiology-based design of multifunctional microemulsion eye drops for moderate or severe dry eye: a randomized, quadruple-masked and active-controlled clinical trial

Laihia, J; Järvinen, R; Wylegala, E; Kaarniranta, K. 2019. Acta ophthalmologica. 2020; 98: 244-254

Electrical synapses interconnecting axons revealed in the optic nerve head - a novel model of gap junctions' involvement in optic nerve function

Smedowski, A; Akhtar, S; Liu, X; Pietrucha-Dutczak, M; Podracka, L; Toropainen, E; Alkanaan, A; Ruponen, M; Urtti, A; Varjosalo, M; Kaarniranta, K; Lewin-Kowalik, J. 2019. Acta ophthalmologica. [Epub ahead of print 10 Oct 2019]: 1-10

Expression of VEGFA-regulating miRNAs and mortality in wet AMD

Blasiak, J; Watala, C; Tuuminen, R; Kivinen, N; Koskela, A; Uusitalo-Järvinen, H; Tuulonen, A; Winiarczyk, M; Mackiewicz, J; Zmorzynski, S; Filip, A; Kaarniranta, K. 2019. Journal of cellular and molecular medicine. 23: 8464-8471

Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration

Kaarniranta, Kai; Koskela, Ali; Felszeghy, Szabolcs; Kivinen, Niko; Salminen, Antero; Kauppinen, Aanu. 2019. Biochimie. 159: 49-54

Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium-Role in Dead Cell Clearance and Inflammation

Szatmári-Tóth, M; Ilmarinen, T; Mikhailova, A; Skottman, H; Kauppinen, A; Kaarniranta, K; Kristóf, E; Lytvynchuk, L; Veréb, Z; Fésüs, L; Petrovski, G. 2019. International journal of molecular sciences. 20: 926

Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2019. Cellular and molecular life sciences. 76: 1901-1918

Interplay between Autophagy and the Ubiquitin-Proteasome System and Its Role in the Pathogenesis of Age-Related Macular Degeneration

Blasiak, J; Pawlowska, E; Szczepanska, J; Kaarniranta, K. 2019. International journal of molecular sciences. 20: 210

Life Style Intervention Improves Retinopathy Status - The Finnish Diabetes Prevention Study

Aro, A; Kauppinen, A; Kivinen, N; Selander, T; Kinnunen, K; Tuomilehto, J; Keinänen-Kiukaanniemi, S; Lindström, J; Uusitupa, M; Kaarniranta, K. 2019. Nutrients. 11: 1691

Real Life Experience of Dexamethasone Implant in Refractory Diabetic Macular Oedema

Karttunen, Tommi; Nummelin, Lasse; Kaarniranta, Kai; Kinnunen, Kati. 2019. Clinical ophthalmology. 13: 2583-2590

Resvega alleviates oxidative stress and inflammasome activation in retinal pigment epithelial cells

Bhattarai, Niina; Korhonen, Eveliina; Toppila, Maija; Kaarniranta, Kai; Kauppinen, Anu. 2019. Acta ophthalmologica

Role of Mitochondrial DNA Damage in ROS-Mediated Pathogenesis of Age-Related Macular Degeneration (AMD).

Kaarniranta, K; Pawlowska, E; Szczepanska, J; Jablkowska, A; Blasiak, J. 2019. International journal of molecular sciences. 20: 2374

SQSTM1/p62 regulates the production of IL-8 and MCP-1 in IL-1ß-stimulated human retinal pigment epithelial cells

Korhonen, E; Piippo, N; Hytti, M; Hyttinen, JMT; Kaarniranta, K; Kauppinen, A. 2019. Cytokine. 116: 70-77

Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage

Zeiner, J; Loukovaara, S; Losenkova, K; Zuccarini, M; Korhonen, AM; Lehti, K; Kauppinen, A; Kaarniranta, K; Müller, CE; Jalkanen, S; Yegutkin, GG. 2019. Journal of molecular medicine: jmm. 97: 341-354

The Regulation of NFE2L2 (NRF2) Signalling and Epithelial-to-Mesenchymal Transition in Age-Related Macular Degeneration Pathology

Hyttinen, JMT; Kannan, R; Felszeghy, S; Niittykoski, M; Salminen, A; Kaarniranta, K. 2019. International journal of molecular sciences. 20: 5800

The first ophthalmic Choosing Wisely recommendations in Finland for glaucoma and wet age-related macular degeneration

Tuuminen, R; Sipilä, R; Komulainen, J; Saarela, V; Kaarniranta, K; Tuulonen, A. 2019. Acta ophthalmologica. 97: e808-e810

Ajokorttitodistusten näkövaatimukset

Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 376. Duodecim

Asikloviiri

Seppänen, Matti; Setälä, Niko; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 433-434. Duodecim

Atselastiini

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 469. Duodecim

Atsitromysiini

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 434. Duodecim

Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways

Marchesi, Nicoletta; Thongon, Natthakan; Pascale, Alessia; Provenzani, Alessandro; Koskela, Ali; Korhonen, Eveliina; Smedowski, Adrian; Govoni, Stefano; Kauppinen, Anu; Kaarniranta, Kai; Amadio, Marialaura. 2018. Oxidative medicine and cellular longevity. 2018: 4956080

Bestin tauti

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 194-195. Duodecim

Dinatriumkromoglikaatti

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 470-471. Duodecim

Emedastiini

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 470. Duodecim

Fluoreseiiniangiografia (FAG)

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 394-395. Duodecim

Fluorokinolonit

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 434-435. Duodecim

Fotodynaaminen hoito (PDT)

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 422. Duodecim

Fusidiinihappo

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 435-436. Duodecim

Gansikloviiri

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 436-437. Duodecim

Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome

Piippo, N; Korhonen, E; Hytti, M; Skottman, H; Kinnunen, K; Josifovska, N; Petrovski, G; Kaarniranta, K; Kauppinen, A. 2018. Scientific reports. 8: 6720

Kefuroksiimi

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 437. Duodecim

Klooritetrasykliini

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 437-438. Duodecim

Kloramfenikoli

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 438-439. Duodecim

Leikkauksenjälkeisen silmämunan sisäosien yleistulehduksen hoito

Kaarniranta, Kai; Marttila, Liisa; Seppänen, Matti. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 185-188. Duodecim

Levokabastiini

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 471-472. Duodecim

Lodoksamidi

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 472. Duodecim

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. 2018. Redox biology. 2019; 20: 1-12

Mechanistical retinal drug targets and challenges

Kaarniranta; Kai; Xu, Heping; Kauppinen, Anu. 2018. Advanced drug delivery reviews. 126: 177-184

Mikrobinäytteen otto silmästä

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 407-409. Duodecim

Mitochondrial quality control in AMD: does mitophagy play a pivotal role?

Hyttinen, Juha MT; Viiri, Johanna; Kaarniranta, Kai; Blasiak, Janusz. 2018. Cellular and molecular life sciences. 75: 2991-3008

Molecular Mechanisms Underlying Age-Related Ocular Diseases

Amadio, Marialaura; Kaarniranta, Kai; Xu, Heping; Smedowski, Adrian; Ferrington, Deborah A. 2018. Oxidative medicine and cellular longevity. 2018: 1-2

Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence

Salminen, Antero; Kauppinen, Anu; Kaarniranta, Kai. 2018. Biogerontology. 19: 325-329

Natamysiini

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 439-440. Duodecim

Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolemic mice

Ruotsalainen, Anna-Kaisa; Lappalainen, Jari P; Heiskanen, Emmi; Merentie, Mari; Näpänkangas, Juha; Lottonen-Raikaslehto, Line; Kansanen, Emilia; Adinolfi, Simone; Kaarniranta, Kai; Ylä-Herttuala, Seppo; Jauhiainen, Matti; Pirinen, Eija; Levonen, Anna-Liisa. 2018. Cardiovascular research. 2019; 115: 243-254

Olopatadiini

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 472-473. Duodecim

Optinen valokerroskuvaus (OCT)

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 396-397. Duodecim

Oxidative Stress is the Principal Contributor to Inflammasome Activation in Retinal Pigment Epithelium Cells with Defunct Proteasomes and Autophagy

Piippo, Niina; Korhonen, Eveliina; Hytti, Maria; Kinnunen, Kati; Kaarniranta, Kai; Kauppinen, Anu. 2018. Cellular physiology and biochemistry. 49: 359-367

PGC-1alfa Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD Pathogenesis

Kaarniranta, Kai; Kajdanek, Jakub; Morawiec, Jan; Pawlowska, Elzbieta; Blasiak, Janusz. 2018. International journal of molecular sciences. 19: 2317

Phytochemicals inhibit the immunosuppressive functions of myeloid-derived suppressor cells (MDSC): Impact on cancer and age-related chronic inflammatory disorders.

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2018. International immunopharmacology. 61: 231-240

Propamidiini

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 440. Duodecim

Seroosi retinopatia, nesteinen keskeisen verkkokalvon sairaus

Kivinen, Niko; Kaarniranta, Kai. 2018. Lääkärilehti. 73: 1940-1943

Siklosporiini

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 480-481. Duodecim

Silmänpohjan ikärappeumat

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 192-194. Duodecim

Silmänpohjan kuvantaminen yleistyy ja tarkentuu

Kivinen, Niko; Tuulonen, Anja; Kaarniranta, Kai. 2018. Duodecim. 134: 1235-1243

Silmätautien käsikirja

Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. 2018. . . Duodecim

Silmävärve (nystagmus)

Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 290-291. Duodecim

Special issue on Molecular Mechanisms Underlying Age-Related Ocular Diseases

Amadio, Marialaura; Kaarniranta, Kai; Xu, Heping; Smedowski, Adrian; Ferrington, Deborah A. 2018. Oxidative medicine and cellular longevity. . Hindawi publishing corporation

Suppressed heat shock protein response in the kidney of exercise-trained diabetic rats

Lappalainen, J; Oksala, NKJ; Laaksonen, DE; Khanna, S; Kokkola, T; Kaarniranta, K; Sen, CK; Atalay, M. 2018. Scandinavian journal of medicine and science in sports. 28: 1808-1817

Survival and functionality of xeno-free human embryonic stem cell-derived retinal pigment epithelial cells on polyester substrate after transplantation in rabbits

Ilmarinen, T; Thieltges, F; Hongisto, H; Juuti-Uusitalo, K; Koistinen, A; Kaarniranta, K; Brinken, R; Braun, N; Holz, FG; Skottman, H; Stanzel, BV. 2018. Acta ophthalmologica. 2019; 97: e688-e699

Tear film proteome in age-related macular degeneration

Winiarczyk, Mateusz; Kaarniranta, Kai; Winiarczyk, Stanislaw; Adaszek, Lukasz; Winiarczyk, Dagmara; Mackiewicz, Jerzy. 2018. Graefes archive for clinical and experimental ophthalmology. 256: 1127-1139

The potential importance of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of Alzheimer's disease

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2018. Cellular and molecular life sciences. 75: 3099-3120

The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2018. Ageing research reviews. 48: 1-10

Tobramysiini

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 440-441. Duodecim

Verkkokalvohalkio

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 182-183. Duodecim

Verkkokalvon keskeinen nesteirtauma

Kivinen, Niko; Kaarniranta, Kai; Seppänen, Matti. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 184-185. Duodecim

Wound healing of human embryonic stem cell-derived retinal pigment epithelial cells is affected by maturation stage

Khamidakh, Amna E Abu; Rodriguez-Martinez, Alejandra; Kaarniranta, Kai; Kallioniemi, Anne; Skottman, Heli; Hyttinen, Jari; Juuti-Uusitalo, Kati. 2018. Biomedical engineering online. 17: 102

Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells

Juuti-Uusitalo K, Koskela A, Kivinen N, Viiri J, Hyttinen JMT, Reinisalo M, Koistinen A, Uusitalo H, Sinha D, Skottman H, Kaarniranta K. 2017. International journal of molecular sciences. 18: 1089

CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells

Hytti M, Andjelic S, Josifovska N, Piippo N, Korhonen E, Hawlina M, Kaarniranta K, Nevalainen TJ, Petrovski G, Parkkari T, Kauppinen A. 2017. Scientific reports. 7: 16169

Cellular Senescence in Age-Related Macular Degeneration: Can Autophagy and DNA Damage Response Play a Role?

Blasiak Janusz, Piechota Malgorzata, Pawlowska Elzbieta, Szatkowska Magdalena, Sikora Ewa, Kaarniranta Kai. 2017. Oxidative medicine and cellular longevity. 2017: 5293258

Contacting co-culture of human retinal microvascular endothelial cells alters barrier function of human embryonic stem cell derived retinal pigment epithelial cells

Skottman H, Muranen J, Lähdekorpi H, Pajula E, Mäkelä K, Koivusalo L, Koistinen A, Uusitalo H, Kaarniranta K, Juuti-Uusitalo K. 2017. Experimental cell research. 359: 101-111

Cytoarchitecture of epithelial inflammatory infiltration indicates the aetiology of infectious keratitis

Smedowski A, Tarnawska D, Orski M, Wroblewska-Czajka E, Kaarniranta K, Aragona P, Wylegala E. 2017. Acta ophthalmologica. 95: 405-413

DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells - Implications for age-related macular degeneration (AMD)

Hyttinen JMT, Blasiak J, Niittykoski M, Kinnunen K, Kauppinen A, Salminen A, Kaarniranta K. 2017. Ageing research reviews. 36: 64-77

Depletion of the Third Complement Component Ameliorates Age-Dependent Oxidative Stress and Positively Modulates Autophagic Activity in Aged Retinas in a Mouse Model

Roginska Dorota, Kawa Milosz P, Pius-Sadowska Ewa, Lejkowska Renata, Luczkowska Karolina, Wiszniewska Barbara, Kaarniranta Kai, Paterno Jussi J, Schmidt Christian A, Machalinski Boguslaw, Machalinska Anna. 2017. Oxidative medicine and cellular longevity. 2017: 5306790

Hypoxia and inflammation in the release of VEGF and interleukins from human retinal pigment epithelial cells

Arjamaa Olli, Aaltonen Vesa, Piippo Niina, Csont Tamás, Petrovski Goran, Kaarniranta Kai, Kauppinen Anu. 2017. Graefes archive for clinical and experimental ophthalmology. 255: 1757-1762

Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease

Salminen Antero, Kauppinen Anu, Kaarniranta Kai. 2017. Journal of neurochemistry. 140: 536-549

Increased intraocular pressure alters the cellular distribution of HuR protein in retinal ganglion cells : a possible sign of endogenous neuroprotection failure

Smedowski A, Liu X, Podracka L, Akhtar S, Trzeciecka A, Pietrucha-Dutczak M, Lewin-Kowalik J, Urtti A, Ruponen M, Kaarniranta K, Varjosalo M, Amadio M. 2017. Biochimica et biophysica acta: molecular basis of disease. 2018; 1864: 296-306

Individual benefits of enoxaparin treatment in branch vein occlusion

Dragoni, Francesco; Kaarniranta, Kai. 2017. Graefes archive for clinical and experimental ophthalmology. 2018; 256: 1031-1033

Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity

Salminen A, Kaarniranta K, Kauppinen A. 2017. Cellular signalling. 40: 10-21

Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs)

Kinnunen K, Piippo N, Loukovaara S, Hytti M, Kaarniranta K, Kauppinen A. 2017. Journal of cell communication and signaling. 11: 275-279

NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy

Loukovaara S, Piippo N, Kinnunen K, Hytti M, Kaarniranta K, Kauppinen A. 2017. Acta ophthalmologica. 95: 803-808

Outcome of anti-vascular endothelial growth factor therapy for neovascular age-related macular degeneration in real-life setting

Kataja, M; Hujanen, P; Huhtala, H; Kaarniranta, K; Tuulonen, A; Uusitalo-Jarvinen, H. 2017. British journal of ophthalmology. 2018; 102: 959-965

Oxidative Stress, Epigenetics, Environment, and Epidemiology of Diabetic Retinopathy

Petrovski G, Kaarniranta K, Petrovic D. 2017. Journal of Diabetes Research. [Published online 2017 Feb 22]: 1-2

Oxidized low-density lipoprotein, lipid and calcium aggregates reveal oxidative stress and inflammation in the conjunctiva of glaucoma patients

Helin-Toiviainen M, Rönkkö S, Kaarniranta K, Puustjärvi T, Rekonen P, Ollikainen M, Uusitalo H. 2017. Acta ophthalmologica. 95: 378-385

Predictive factors in endonasal endoscopic lacrimal surgery: a review

Penttilä E, Smirnov G, Kaarniranta K, Seppä J, Tuomilehto H. 2017. B-ent. 13: 129-135

Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses

Salminen Antero, Kaarniranta Kai, Kauppinen Anu. 2017. Ageing research reviews. 37: 79-93

Silmänpohjan ikärappeuman patogeneesi - autofagian ja inflammasomien vuoropuhelua

Kivinen Niko, Koskela Ali, Kauppinen Anu, Kaarniranta kai. 2017. Duodecim. 133: 641-646

The Finnish national guideline for diagnosis, treatment and follow-up of patients with wet age related macular degeneration

Tuuminen Raimo, Uusitalo-Järvinen Hannele, Aaltonen Vesa, Hautala Nina, Kaipiainen Sulevi, Laitamäki Nina, Ollila Marko, Rantanen Jari, Välimäki Satu, Sipilä Raija, Laukkala Tanja, Komulainen Jorma, Tommila Petri, Immonen Ilkka, Tuulonen Anja, Kaarniranta Kai. 2017. Acta ophthalmologica. 95: 1-9

The Finnish national guideline for diagnosis, treatment and follow-up of patients with wet age-related macular degeneration

Tuuminen R, Tuulonen A, Kaarniranta K. 2017. Acta ophthalmologica. 95: 649-650

The Nobel Prized cellular target autophagy in eye diseases

Kaarniranta Kai, Petrovski Goran, Kauppinen Anu. 2017. Acta ophthalmologica. 95: 335-336

Topical cis-urocanic acid prevents ocular surface irritation in both IgE -independent and -mediated rat model

Jauhonen HM, Laihia J, Oksala O, Viiri J, Sironen R, Alajuuma P, Kaarniranta K, Leino L. 2017. Graefes archive for clinical and experimental ophthalmology. 255: 2357-2362

Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cell

Hytti M, Szabó D, Piippo N, Korhonen E, Honkakoski P, Kaarniranta K, Petrovski G, Kauppinen A. 2017. Journal of nutritional biochemistry. 42: 37-42

Visual processing in patients with age-related macular degeneration performing a face detection test

Vottonen Pasi, Kaarniranta Kai, Pääkkönen Ari, Tarkka Ina M. 2017. Clinical ophthalmology. 11: 1245-1252

AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms

Salminen Antero, Kaarniranta Kai, Kauppinen Anu. 2016. Biogerontology. 17: 655-680

AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions

Salminen Antero, Kauppinen Anu, Kaarniranta Kai. 2016. Cellular signalling. 28: 887-895

Absence of collagen XVIII in mice causes age-related insufficiency in retinal pigment epithelium proteostasis

Kivinen Niko, Felszeghy Szabolcs, Kinnunen Aino I, Setälä Niko, Aikio Mari, Kinnunen Kati, Sironen Reijo, Pihlajaniemi Taina, Kauppinen Anu, Kaarniranta Kai. 2016. Biogerontology. 17: 749-761

Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways

Salminen Antero, Kaarniranta Kai, Kauppinen Anu. 2016. Ageing research reviews. 28: 15-26

All-Trans Retinoic Acid Modulates DNA Damage Response and the Expression of the VEGF-A and MKI67 Genes in ARPE-19 Cells Subjected to Oxidative Stress

Tokarz Paulina, Piastowska-Ciesielska Agnieszka Wanda, Kaarniranta Kai, Blasiak Janusz. 2016. International journal of molecular sciences. 17: 898

Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration

Kaarniranta K, Tokarz P, Koskela A, Paterno J, Blasiak J. 2016. Cell biology and toxicology. 2017; 33: 113-128

Benefits of switching from latanoprost to preservative-free tafluprost eye drops: a meta-analysis of two Phase IIIb clinical trials

Uusitalo Hannu, Egorov Evjeniy, Kaarniranta Kai, Astakhov Yuri, Ropo Auli. 2016. Clinical ophthalmology. 10: 445-454

Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration

Szatmári-Tóth M, Kristóf E, Veréb Z, Akhtar S, Facskó A, Fésus L, Kauppinen A, Kaarniranta K, Petrovski G. 2016. Cell death and disease. 7: e2367

Dry Eye Disease - Nordic Guidelines 2016

Heegaard S, Knudsen LL, van Setten G, Koranyi G, Holopainen J, Kaarniranta K, Klyve P, Raeder S. 2016. . . -

FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process

Salminen Antero, Kauppinen Anu, Kaarniranta Kai. 2016. Journal of molecular medicine: jmm. 2017; 95: 123-131

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky Daniel J, Abdelmohsen Kotb, Abe Akihisa, Abedin Md Joynal, Abeliovich Hagai, Acevedo Arozena Abraham, Adachi Hiroaki, Adams Christopher M, Adams Peter D, Adeli Khosrow, Adhihetty Peter J, Adler Sharon G, Agam Galila, Agarwal Rajesh, Aghi Manish K, Agnello Maria, Agostinis Patrizia, Aguilar Patricia V, Aguirre-Ghiso Julio, Airoldi Eduardo M et al. 2016. Autophagy. 12: 1-222

Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases

Salminen Antero, Kaarniranta Kai, Kauppinen Anu. 2016. Aging and disease. 7: 180-200

Inflammation and its role in age-related macular degeneration

Kauppinen Anu, Paterno Jussi J, Blasiak Janusz, Salminen Antero, Kaarniranta Kai. 2016. Cellular and molecular life sciences. 73: 1765-1786

Inhibition of BET bromodomains alleviates inflammation in human RPE cells

Hytti Maria, Tokarz P, Määttä E, Piippo Niina, Korhonen Eveliina, Suuronen T, Honkakoski Paavo, Kaarniranta Kai, Lahtela-Kakkonen Maija, Kauppinen Anu. 2016. Biochemical pharmacology. 110-111: 71-79

Inhibition of DNA methyltransferase or histone deacetylase protects retinal pigment epithelial cells from DNA damage induced by oxidative stress by the stimulation of antioxidant enzymes

Tokarz Paulina, Kaarniranta Kai, Blasiaka Janusz. 2016. European journal of pharmacology. 776: 167-175

Kostea silmänpohjan ikärappeuma (AMD)

Tuuminen R, Uusitalo-Järvinen H, Aaltonen V, Hautala N, Kaipiainen S, Laitamäki N, Ollila M, Rantanen J, Välimäki S, Sipilä R, Laukkala T, Komulainen J, Tommila P, Immonen I, Tuulonen A, Kaarniranta K. Teoksessa: -(toim.) , 2016. Käypä hoito. Suomalaisen Lääkäriseuran Duodecimin ja Suomen Fysiatriyhdistyksen asettama työryhmä. s. -. Duodecim

Long-term topical application of preservative-free prostaglandin analogues evokes macrophage infiltration in the ocular adnexa

Trzeciecka Anna, Paterno J Jussi, Toropainen Elisa, Koskela Ali, Podracka Lucia, Korhonen Eveliina, Kauppinen Anu, Kaarniranta Kai, Smedowski Adrian. 2016. European journal of pharmacology. 788: 12-20

Lääketieteen Nobelin palkinto autofagian tutkijalle

Kaarniranta Kai, Meri Seppo, Eskelinen Eeva-Liisa. 2016. Duodecim. 132: 2141-2144

Melatonin in retinal physiology and pathology: the case of age-related macular degeneration

Blasiak J, Reiter RJ, Kaarniranta K. 2016. Oxidative medicine and cellular longevity. 2016: 6819736, 12 pages

Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells

Koskela Ali, Reinisalo Mika, Petrovski Goran, Sinha Debasish, Olmiere Céline, Karjalainen Reijo, Kaarniranta Kai. 2016. Nutrients. 8: 284

Nya behandlingar vid synhotande makulasjukdomer

Paterno J, Ikäheimo K, Kinnunen K, Kaarniranta K. 2016. Finska läkaresällskapets handlingar. 176: 10-14

2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process

Salminen Antero, Kauppinen Anu, Kaarniranta Kai. 2015. Cellular and molecular life sciences. 72: 3897-3914

A novel proteotoxic stress associated mechanism for macular corneal dystrophy

Kaarniranta Kai, Szalai Eszter, Smedowski Adrian, Hegyi Zoltán, Kivinen Niko, Viiri Johanna, Wowra Bogumil, Dobrowolski Dariusz, Módis Jr. László, Berta András, Wylegala Edward, Felszeghy Szabolcs. 2015. Histology and histopathology. 30: 921-930

A randomized phase I clinical study of cis-urocanic acid eye drops in healthy adult subjects

Jauhonen Hanna-Mari, Kari Eeva, Pylkkänen Liisa, Poutanen Jutta, Laihia Jarmo, Kaarniranta Kai, Leino Lasse. 2015. Acta ophthalmologica. 93: 368-376

Ageing of the vitreous: From acute onset floaters and flashes to retinal detachment

Lumi Xhevat, Hawlina Marko, Glavac Damjan, Facsko Andrea, Moe Morten C, Kaarniranta Kai, Petrovski Goran. 2015. Ageing research reviews. 21: 71-77

Autophagy in DNA Damage Response

Czarny Piotr, Pawlowska Elzbieta, Bialkowska-Warzecha Jolanta, Kaarniranta Kai, Blasiak Janusz. 2015. International journal of molecular sciences. 16: 2641-2662

Best-corrected visual acuity and retinal thickness are associated with improved cortical visual processing in treated wet AMD patients

Vottonen Pasi, Pääkkönen Ari, Tarkka Ina M, Kaarniranta Kai. 2015. Acta ophthalmologica. 93: 621-25

Climatic droplet keratopathy: an old disease in new clothes

Serra Horacio M, Holopainen Juha M, Beuerman Roger, Kaarniranta Kai, Suarez Maria F, Urrets-Zavalia Julio A. 2015. Acta ophthalmologica. 93: 496-504

Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration

Ferrington Deborah A, Sinha Debasish, Kaarniranta Kai. 2015. Progress in retinal and eye research. 2016; 51: 69-89

Diabeettisen retinopatian uudet hoidot ja diagnostiikka

Karttunen Tommi, Kaarniranta Kai, Kinnunen Kati. 2015. DIABETES JA LÄÄKÄRI. 44: 17-22

Endoscopic dacryocystorhinostomy as treatment for lower lacrimal pathway obstructions in adults : Review article

Penttilä Elina, Smirnov Grigori, Tuomilehto Henri, Kaarniranta Kai, Seppä Juha. 2015. Allergy and rhinology. 6: e12-e19

Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation

Hytti Maria, Piippo Niina, Korhonen Eveliina, Honkakoski Paavo, Kaarniranta Kai, Kauppinen Anu. 2015. Scientific reports. 5:

Health-related quality of life after caract surgery with the phacoemulsification technique and intraocular lens implantation

Porela-Tiihonen Susanna, Roine Risto P, Sintonen Harri, Kaarniranta Kai, Kokki Merja, Kokki Hannu. 2015. Acta ophthalmologica. 2016; 94: 21-25

Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape

Salminen Antero, Haapasalo Annakaisa, Kauppinen Anu, Kaarniranta Kai, Soininen Hilkka, Hiltunen Mikko. 2015. Progress in neurobiology. epub ahead of print 19 May 2015:

Lysosomes: Regulators of autophagy in the retinal pigmented epithelium

Sinha Debasish, Valapala Mallika, Shang Peng, Hose Stacey, Grebe Rhonda, Lutty Gerard A, Zigler Jr J Samuel, Kaarniranta Kai, Handa James T. 2015. Experimental eye research. 144 (2016): 46-53

Pharmacokinetics, Efficacy, and Safety of the Preservative-free Fixed Combination of Tafluprost 0.0015 % and Timolol 0.5 % in Healthy Volunteers: A Phase I Comparison vs. the Corresponding Preservative-free Monotherapies

Kaarniranta Kai, Ikäheimo Kirsi, Mannermaa Eliisa, Ropo Auli. 2015. Clinical pharmacokinetics. [epub ahead of print 21 Sep 2015]: 1-10

Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases

Reinisalo Mika, Kårlund Anna, Koskela Ali, Kaaniranta Kai, Karjalainen Reijo O.. 2015. Oxidative medicine and cellular longevity. 2015, Article ID 340520: 24 p.

Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells

Hytti Maria, Piippo Niina, Salminen Antero, Honkakoski Paavo, Kaarniranta Kai, Kauppinen Anu. 2015. Experimental eye research. 132: 208-215

Role of the cell cycle re-initiation in DNA damage response of post-mitotic cells and its implication in the pathogenesis of neurodegenerative diseases

Tokarz Paulina, Kaarniranta Kai, Blasiak Janusz. 2015. Rejuvenation research. 19: 1-9

The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells

Johansson Ida, Monsen Vivi Talstad, Pettersen Kristine, Mildenberger Jennifer, Misund Kristine, Kaarniranta Kai, Schønberg Svanhild, Bjørkøy Geir. 2015. Autophagy. 11: 1636-1651

A 6-month study comparing efficacy, safety, and tolerability of the preservative-free fixed combination of tafluprost 0.0015% and timolol 0.5% versus each of its individual preservative-free components

Pfeiffer N, Traverso CE, Lorenz K, Saarela V, Liinamaa J, Uusitalo H, Astakhov Y, Boiko E, Ropo A, Preservative-free Tafluprost/Timolol Fixed Combination Study Group Collaborators: Uusitalo H, Kaarniranta K,Saarela V, Pfeiffer N, Bartz-Schmidt U, Dunker S, Hamacher T, Heidemann K,Hofmann G, et al.. 2014. Advances in therapy. 31: 1228-1246

A rat experimental model of glaucoma incorporating rapid-onset elevation of intraocular pressure

Smedowski A, Pietrucha-Dutczak M, Kaarniranta K, Lewin-Kowalik J. 2014. Scientific reports. 4: 5910; 1-11

ADAMTS9 locus associates with increased risk of wet AMD

Helisalmi Seppo, Immonen Ilkka, Losonczy Gergely, Resch Miklos D, Benedek Szabolcs, Balogh Istvan, Papp Andras, Berta Andras, Uusitupa Matti, Hiltunen Mikko, Kaarniranta Kai. 2014. Acta ophthalmologica. 2014: 1

Bevacizumab does not affect autophagy clearance during proteasomal inhibition in human retinal pigment epithelial cells

Kivinen Niko, Dithmer Michaela, Kinnunen Kati, Lucius Ralph, Roider Johann, Kaarniranta Kai, Klettner Alexa. 2014. Journal of biochemical and pharmacological research. 2: 44-53

CB2 receptor as a potential target in age-related diseases

Kauppinen Anu, Nevalainen Tapio, Hytti Maria, Salminen Antero, Kaarniranta Kai, Parkkari Teija. 2014. Journal of biochemical and pharmacological research. 2: 33-43

Cationorm shows good tolerability on human HCE-2 corneal epithelial cell cultures

Kinnunen Kati, Kauppinen Anu, Piippo Niina, Koistinen Arto, Toropainen Elisa, Kaarniranta Kai. 2014. Experimental eye research. 120: 82-89

Clearance of misfolded and aggregated proteins by aggrephagy and implications for aggregation diseases

Hyttinen JM, Amadio M, Viiri J, Pascale A, Salminen A, Kaarniranta K. 2014. Ageing research reviews. 18: 16-28

Comparison of three intraocular pressure measurement methods including biomechanical properties of the cornea

Smedowski Adrian, Weglarz Beata, Tarnawska Dorota, Kaarniranta Kai, Wylegala Edward. 2014. Investigative ophthalmology and visual science. 55: 666-673

Decline in cellular clearance systems induces inflammasome signaling in human ARPE-19 cells

Piippo N, Korkmaz A, Hytti M, Kinnunen K, Salminen A, Atalay M, Kaarniranta K, Kauppinen A. 2014. Biochimica et biophysica acta: molecular cell research. 1843: 3038-3046

Estrogen Signalling in the Pathogenesis of Age-Related Macular Degeneration

Kaarniranta Kai, Machalinska Anna, Veréb Zoltán, Salminen Antero, Petrovski Goran, Kauppinen Anu. 2014. Current eye research. 2014: 1-8

Excipients of preservative-free latanoprost induced inflammatory response and cytotoxicity in immortalized human HCE-2 corneal epithelial cells

Smedowski Adrian, Paterno Jussi J, Toropainen Elisa,Sinha Debasish, Wylegala Edward, Kaarniranta Kai. 2014. Journal of biochemical and pharmacological research. 2: 175-184

Herpes simplex virus types 1 and 2 modulate autophagy in SIRC corneal cells

Petrovski G, Pásztor K, Orosz L, Albert R, Mencel E, Moe MC, Kaarniranta K, Facskó A, Megyeri K. 2014. Journal of biosciences. 39: 683-692

Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process

Salminen Antero, Kaarniranta Kai, Hiltunen Mikko, Kauppinen Anu. 2014. Journal of molecular medicine: jmm. -: -

Hsp70 binds reversibly to proteasome inhibitor-induced protein aggregates and evades autophagic clearance in ARPE-19 cells

Kivinen Niko, Hyttinen Juha MT, Viiri Johanna, Paterno Jussi, Felszheghy Szabolcs, Kauppinen Anu, Salminen Antero, Kaarniranta Kai. 2014. Journal of biochemical and pharmacological research. 2: 1-7

Hypoxic conditions stimulate the release of B-type natriuretic peptide from human retinal pigment epithelium cell culture

Aaltonen Vesa, Kinnunen Kati, Jouhilahti Eeva-Mari, Peltonen Juha, Nikinmaa Mikko, Kaarniranta Kai, Arjamaa Olli. 2014. Acta ophthalmologica. 92: 740-744

Inflammaging Signaling in Health Span and Life Span Regulation: Next Generation Targets for Longevity

Salminen A, Kauppinen A, Kaarniranta K. Teoksessa: Irfan Rahman and Debasis Bagchi(toim.) , 2014. Inflammation, Advancing Age and Nutrition: Research and Clinical Interventions. s. 323-332. Academic press

Krebs cycle dysfunction shapes epigenetic landscape of chromatin: Novel insights into mitochondrial regulation of aging process

Salminen Antero, Kaarniranta Kai, Hiltunen Mikko, Kauppinen Anu. 2014. Cellular signalling. 26: 1598-1603

Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process

Salminen Antero, Kauppinen Anu, Hiltunen Mikko, Kaarniranta Kai. 2014. Ageing research reviews. 16: 45-65

Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress

Oksala Niku KJ, Ekmekci F Güler, Özsoy Ergi, Kirankaya Serife, Kokkola Tarja, Emecen Güzin, Lappalainen Jani, Kaarniranta Kai, Atalay Mustafa. 2014. Redox biology. 3: 25-28

Oxidative Stress Protection by Exogenous Delivery of rhHsp70 Chaperone to the Retinal Pigment Epithelium (RPE), a Possible Therapeutic Strategy Against RPE Degeneration

Subrizi Astrid, Toropainen Elisa, Ramsay Eva, Airaksinen Anu J, Kaarniranta Kai, Urtti Arto. 2014. Pharmaceutical research. 2015; 32: 211-221

Oxidative stress plays an important role in zoledronic acid-induced autophagy

Khandelwal VK, Mitrofan LM, Hyttinen JM, Chaudhari KR, Buccione R, Kaarniranta K, Ravingerová T, Mönkkönen J. 2014. Physiological research. 63: S601-S612

Oxidative stress, hypoxia, and autophagy in the neovascular processes of age-related macular degeneration

Blasiak Janusz, Petrovski Goran, Veréb Zoltan, Facskó Andrea, Kaarniranta Kai. 2014. Journal of biomedicine and biotechnology. 2014: 1-7

Pinosylvin-mediated protection against oxidative stress in human retinal pigment epithelial cells

Koskela Ali, Reinisalo Mika, Hyttinen Juha MT, Kaarniranta Kai, Karjalainen Reijo O. 2014. Molecular vision. 20: 760-769

Recovery and patient satisfaction after cataract surgery. A one-year prospective follow-up study

Porela-Tiihonen S, Kaarniranta K, Kokki M, Kokki H. 2014. Acta ophthalmologica. 93: e172-e173

Silmänpohjan kostea ikärappeuma pitää hoitaa ajoissa

Kinnunen K, Kaarniranta K. 2014. Lääkärilehti. 69: 2265-2268

Structure and barrier properties of human embryonic stem cell-derived retinal pigment epithelial cells are affected by extracellular matrix protein coating

Sorkio Anni, Hongisto Heidi, Kaarniranta Kai, Uusitalo Hannu, Juuti-Uusitalo Kati, Skottman Heli. 2014. Tissue engineering. 20: 622-634

Upregulation of inflammatory genes in the nasal mucosa of patients undergoing endonasal dacryocystorhinostomy

Penttilä E, Hyttinen JMT, Hytti M, Kauppinen A, Smirnov G, Tuomilehto H, Seppä J, Nuutinen J, Kaarniranta K. 2014. Clinical ophthalmology. 8: 799-805

A prospective study on postoperative pain after cataract surgery.

Porela-Tiihonen S, Kaarniranta K, Kokki M, Purhonen S, Kokki H. 2013. Clinical ophthalmology. 7: 1429-1435

Antagonistic crosstalk between NF-kappaB and SIRT1 in the regulation of inflammation and metabolic disorders

Kauppinen A, Suuronen T, Ojala J, Kaarniranta K, Salminen A. 2013. Cellular signalling. 25: 1939-1948

Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells

Viiri J, Amadio M, Marchesi N, Hyttinen JM, Kivinen N, Sironen R, Rilla K, Akhtar S, Provenzani A, D'Agostino VG, Govoni S, Pascale A, Agostini H, Petrovski G, Salminen A, Kaarniranta K. 2013. PLoS ONE. 8: e6963, 16 pages

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

Kaarniranta K, Sinha D, Blasiak J, Kauppinen A, Vereb Z, Salminen A, Boulton ME, Petrovski G. 2013. Autophagy. 9: 1-12

Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process

Salminen A, Kaarniranta K, Kauppinen A. 2013. Ageing research reviews. 12: 520-534

Cellular and molecular mechanisms of age-related macular degeneration: From impaired autophagy to neovascularization

Klettner A, Kauppinen A, Blasiak J, Roider J, Salminen A, Kaarniranta K. 2013. International journal of biochemistry and cell biology. 45: 1457-1467

Changes in neurophysiologic markers of visual processing following beneficial anti-VEGF treatment in macular degeneration

Vottonen P, Kaarniranta K, Pääkkönen A, Tarkka IM. 2013. Clinical ophthalmology. 7: 437-442

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process

Salminen A, Kaarniranta K, Kauppinen A. 2013. International journal of molecular sciences. 14: 3834-3859

Epigenetic regulation of ASC/TMS1 expression: potential role in apoptosis and inflammasome function

Salminen A, Kauppinen A, Hiltunen M, Kaarniranta K. 2013. Cellular and molecular life sciences. -: -

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. 2013. Progress in neurobiology. 106-107: 33-54

Inflammation as a target of minocycline: special interest in the regulation of inflammasome signaling

Kauppinen A, Salminen A, Kaarniranta K. 2013. Inflammasome. 1: 2-14

Maturation of autophagosomes and endosomes: A key role for Rab7

Hyttinen JMT, Niittykoski M, Salminen A, Kaarniranta K. 2013. Biochimica et biophysica acta: international journal of biochemistry and biophysics. 1833: 503-510

Mitochondrial and nuclear DNA damage and repair in age-related macular degeneration

Blasiak J, Glowacki S, Kauppinen A, Kaarniranta K. 2013. International journal of molecular sciences. 14: 2996-3010

Oxidative DNA Damage and Proteostasis in Age-Related Macular Degeneration

Tokarz P, Kauppinen A, Kaarniranta K, Blasiak J. 2013. Journal of biochemical and pharmacological research. 1: 106-113

Postoperative pain after cataract surgery

Porela-Tiihonen S, Kaarniranta K, Kokki H. 2013. Journal of cataract and refractive surgery. 39: 789-98

Potential of epigenetic mechanisms in AMD pathology

Blasiak J, Salminen A, Kaarniranta K. 2013. FRONTIERS IN BIOSCIENCE. 5: 412-425

Retinal arterial macroaneurysms

Pitkänen L, Tommila P, Kaarniranta K, Jääskeläinen JE, Kinnunen K. 2013. Acta ophthalmologica. 2013: 1-4

Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD)

Tokarz P, Kaarniranta K, Blasiak J. 2013. Biogerontology. 14: 461-82

Silmänpohjan kostean ikärappeuman hoito

Kaarniranta K. 2013. Terveydenhoitoviesti. 1: 20

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

Salminen A, Kaarniranta K. 2012. Ageing research reviews. 11: 230-241

Adiponectin receptor 1 gene (ADIPOR1) variant is associated with advanced age-related macular degeneration in Finnish population

Kaarniranta K, Paananen J, Nevalainen T, Sorri I, Seitsonen S, Immonen I, Salminen A, Pulkkinen L, Uusitupa M. 2012. Neuroscience letters. 513: 233-237

Aikuisten alakyyneltietukosten kirurginen hoito

Seppä J, Smirnov G, Kaarniranta K, Tuomilehto H. 2012. Duodecim. 128: 205-2011

Autophagy in the eye: a double-edged sword, (Chapter 8)

Petrovski, G; Albert, R; Kaarniranta, K; Morten, CM; Fésus, L; Berta, A; Das, DK. Teoksessa: Ed. Gorbunov, Nikolai(toim.) , 2012. Autophagy: Principles, Regulation & Roles in Disease.. s. 157-180. Nova science publishers

Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration

Kaarniranta K, Kauppinen A, Blasiak J, Salminen A. 2012. Future medicinal chemistry. 4: 2153-2161

Bilberries potentially alleviate stress-related retinal gene expression induced by a high-fat diet in mice

Mykkänen OT, Kalesnykas G, Adriaens M, Evelo CT, Törrönen R, Kaarniranta K. 2012. Molecular vision. 18: 2338-2351

Context-dependent regulation of autophagy by IKK-NF-kappaB signaling: Impact on the aging process

Salminen A, Hyttinen JMT, Kauppinen A, Kaarniranta K. 2012. International journal of cell biology. 2012: 15 pages

Efflux Protein Expression in Human Stem Cell-Derived Retinal Pigment Epithelial Cells

Juuti-Uusitalo, K; Vaajasaari, H; Ryhänen, T; Narkilahti, S; Suuronen, R; Mannermaa, E; Kaarniranta, K; Skottman, H. 2012. PLoS ONE. 7: 1-10

Emerging role of NF-kappaB signaling in the induction of senescence-associated secretory phenotype (SASP)

Salminen A, Kauppinen A, Kaarniranta K. 2012. Cellular signalling. 24: 835-845

Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease

Salminen, A; Kaarniranta, K; Haapasalo, A; Hiltunen, M; Soininen, H; Alafuzoff, I. 2012. Progress in neurobiology. 96: 87-95

Fibrillin-2, tenascin-C, matrilin-2, and matrilin-4 are strongly expressed in the epithelium of human granular and lattice type I corneal dystrophies

Szalai, E; Felszeghy, S; Hegyi, Z; Módis, L Jr; Berta, A; Kaarniranta, K. 2012. Molecular vision. 18: 1927-1936

Genetic Variability in DNA Repair Proteins in Age-Related Macular Degeneration

Blasiak, J; Synowiec, E; Salminen, A; Kaarniranta, K. 2012. International journal of molecular sciences. 13: 13378-13379

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, DJ, Abdalla, FC; Abeliovich, H; Abraham, RT; Acevedo-Arozena, A; Adeli, K; Agholme, L; Agnello, M; Agostinis, P; Aguirre-Ghiso, JA; Ait-Mohamed, O; Ait-Si-Ali, S; Akematsu, T; Akira, S; Al-Younes, HM; Al-Zeer, MA; Albert, ML; Albin, RL; Alegre-Abarrategui, J; Kaarniranta, K; et al.. 2012. Autophagy. 8: 445-544

Inflammaging: disturbed interplay between autophagy and inflammasomes

Salminen, A; Kaarniranta, K; Kauppinen, A. 2012. Aging. 4: 166-175

Mitochondrial dysfunction and oxidative stress active inflammasomes: impact on the aging process and age-related diseases

Salminen A, Ojala J, Kaarniranta K, Kauppinen A. 2012. Cellular and molecular life sciences. 69: 2999-3013

Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration

Kinnunen, K; Petrovski, G; Moe, MC; Berta, A; Kaarniranta, K. 2012. Acta ophthalmologica. 90: 299-309

Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells - Implications for age-related macular degeneration (AMD)

Kauppinen A, Niskanen H, Suuronen T, Kinnunen K, Salminen A, Kaarniranta K. 2012. Immunology letters. 147: 29-33

Phytochemicals suppress nuclear factor-kappaB signaling: impact on health span and the aging process

Salminen A, Kauppinen A, Kaarniranta K. 2012. Current opinion in clinical nutrition and metabolic care. 15: 23-28

Protective function of wood-derived stilbenes against oxidative stress and inflammation in ARPE-19 cells

Mika Reinisalo, Tuomas Paimela, Tuomas Ryhänen, Anu Kauppinen, Ali Koskela, Tuula Soininen, Kai Kaarniranta, Reijo Karjalainen. 2012.

Protein-oxidized phospholipid interactions in cellular signaling for cell death: From biophysics to clinical correlations

Kinnunen, PK; Kaarniranta, K; Mahalka, AK. 2012. Biochimica et biophysica acta: biomembranes. 1818: 2446-2455

Relation of biometric eye profile with intraocular pressure corrections in healthy myopes

Pärssinen, O; Hiltunen, H; Kaarniranta, K. 2012. Acta ophthalmologica. 90: e410-412

Silmänpohjan ikärappeuma yleistyy

Kaarniranta, K. 2012. OPTOMETRIA. 3: 39-41

The preservative polyquaternium-1 increases cytoxicity and NF-kappaB linked inflammation in human corneal epithelial cells

Paimela, T; Ryhänen, T; Kauppinen, A; Marttila, L; Salminen, A; Kaarniranta, K. 2012. Molecular vision. 18: 1189-1196

5'-adenosine monophosphate-activated protein kinase-Mammalian target of rapamycin axis as therapeutic target for age-related macular degeneration

Hyttinen JM, Petrovski G, Salminen A, Kaarniranta K. 2011. Rejuvenation research. 14: 651-660

AMP-activated protein kinase inhibits NF-kappaB signaling and inflammation: impact on healthspan and lifespan

Salminen A, Hyttinen JMT, Kaarniranta K. 2011. Journal of molecular medicine: jmm. 89: 667-676

AMP-activated protein kinase: a potential player in Alzheimer's disease

Salminen A, Kaarniranta K, Haapasalo A, Soininen H, Hiltunen M. 2011. Journal of neurochemistry. 118: 460-474

Age-related macular degeneration (AMD): Alzheimer's Disease in the eye

Kaarniranta K, Salminen A, Haapasalo A, Soininen H, Hiltunen M. 2011. Journal of Alzheimer's disease. 24: 615-631

Apoptosis and aging: increased resistance to apoptosis enhances the aging process

Salminen A, Ojala J, Kaarniranta K. 2011. Cellular and molecular life sciences. 68: 1021-1031

Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype

Salminen A, Ojala J, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H. 2011. European journal of neuroscience. 34: 3-11

Biocompatibility of different poly(lactide-coglycolide) polymers implanted into the subconjunctival space in rats

Seppo Rönkkö, Kai Kaarniranta, Giedrius Kalesnykas, Hannu Uusitalo. 2011. Ophthalmic research. 46: 55-65

Celastrol regulates innate immunity response via NF-kappaB and Hsp70 in human retinal pigment epithelial cells

Paimela T, Hyttinen JMT, Viiri J, Ryhänen T, Karjalainen RO, Salminen A, Kaarniranta K. 2011. Pharmacological research. 64: 501-508

Cis-urocanic acid inhibits SAPK/JNK signaling pathway in UV-B exposed human corneal epithelial cells in vitro

Jauhonen H-M, Kauppinen A, Paimela T, Laihia JK, Leino L, Salminen A, Kaarniranta K. 2011. Molecular vision. 17: 2311-2317

Control of p53 and NF-kB signaling by WIP1 and MIF: Role in cellular senescence and organismal aging

Salminen Antero, Kaarniranta Kai. 2011. Cellular signalling. 23: 747-752

Emerging role of p62/sequestosome-1 in th pathogenesis of Alzheimer's disease

Salminen A, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H, Alafuzoff I. 2011. Progress in neurobiology. 96: 87-95

Increased IL-6 levels are not related to NF-kappaB or HIF-1alfa: transcription factors activity in the vitreous of proliferative diabetic retinopathy

Arjamaa O, Pöllönen M, Kinnunen K, Ryhänen T, Kaarniranta K. 2011. Journal of diabetes and its complications. 25: 393-397

Mitomycin C in revision endoscopic dacryocystorhinostomy: A prospective randomized study

Penttilä E, Smirnov G, Seppä J, Kaarniranta K, Tuomilehto H. 2011. American journal of rhinology and allergy. 25: 425-428

Plant flavonol quercetin and isoflavone biochanin-A differentially induce protection against oxidative stress and inflammation in ARPE-cells

Saviranta Niina, Veeroos Laura, Granlund Lars, Hassinen Viivi, Kaarniranta Kai, Karjalainen Reijo. 2011. Food research international. 44: 109-113

Ravistellun lapsen oireyhtymään liittyvät silmälöydökset

Nevalainen T, Kaarniranta K, Puustjärvi T, Kontkanen M. 2011. Lääkärilehti. 66: 453-455

Silmänpohjan ikärappeuman hoidossa halvempi on tehokas ja turvallinen

Kaarniranta K. 2011. Lääkärilehti. 22: 1812

Strong expression of HSP47 in metaplastic nasal mucosa may predict a poor outcome after primary endoscopic dacryocystorhinostomy: a prospective study

Smirnov G, Pirinen R, Tuomilehto H, Seppä J, Teräsvirta M, Uusitalo H, Nuutinen J, Kaarniranta K. 2011. Acta ophthalmologica. 89: e132-e136

Altered calcium signaling in a experimental model of glaucoma

Niittykoski M, Kalesnykas G, Larsson KP, Kaarniranta K, Åkerman KEO, Uusitalo H. 2010. Investigative ophthalmology and visual science. 51: 6387-6393

Autophagy - hot topic in AMD

Kaarniranta K. 2010. Acta ophthalmologica. 88: 387-388

Celastrol: Molecular targets of Thunder God Vine

Salminen A, Lehtonen M, Paimela T & Kaarniranta K. 2010. Biochemical and biophysical research communications. 394: 439 - 442

ER stress and hormetic regulation of the aging process

Salminen A & Kaarniranta K. 2010. Ageing research reviews. 9: 211-217

Endoplasmic reticulum stress in age-related macular degeneration: Trigger for neovascularization

Salminen A, Kauppinen A, Hyttinen JMT, Toropainen E & Kaarniranta K. 2010. MOLECULAR MEDICINE TODAY. 16: 535-542

Filter-cultured ARPE-19 cells as outer blood-retinal barrier model

Mannermaa E, Reinisalo M, Ranta V-P, Vellonen K-S, Kokki H, Saarikko A, Kaarniranta K & Urtti A. 2010. European journal of pharmaceutical sciences. 40: 289-296

Genetics vs. entrophy: Longevity factors suppress the NF-kB-driven entropic aging process

Salminen A & Kaarniranta K. 2010. Ageing research reviews. 9: 298-314

Glycolysis Links p53 Function With NF-kB Signaling: Impact on Cancer and Aging Process

Salminen A & Kaarniranta K. 2010. Journal of cellular physiology. 224: 1-6

Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease

Salminen A, Ojala J, Kaarniranta K, Hiltunen M & Soininen H. 2010. Progress in neurobiology. 93: 99-110

Influence of Hsp90 and HDAC Inhibition and Tubulin Acetylation on Perinuclear Protein Aggregation in Human Retinal Pigment Epithelial Cells

Ryhänen T, Viiri J, Hyttinen JTM, Uusitalo H, Salminen A & Kaarniranta K. 2010. Journal of biomedicine and biotechnology. 2011;2011;798052. Epub 2010 Oct 24: 1-8

Influence of selective estrogen receptor modulators on interleukin-6 expression in human retinal pigment epithelial cells (ARPE-19)

Paimela T, Hyttinen JMT, Viiri J, Ryhänen T, Karvonen MK, Unkila M, Uusitalo H, Salminen A & Kaarniranta K. 2010. European journal of pharmacology. 640: 219-225

Insulin/IGF-1 paradox of aging: Regulation via AKT/IKK/NF-kB signaling

Salminen A & Kaarniranta K. 2010. Cellular signalling. 22: 573-577

Mechanisms of protein aggregation in the retinal pigment epithelial cells

Kai Kaarniranta, Juha Hyttinen, Tuomas Ryhanen, Johanna Viiri, Tuomas Paimela, Elisa Toropainen, Iiris Sorri & Antero Salminen. 2010. FRONTIERS IN BIOSCIENCE. E2: 1374-1384

Regression of necrotizing scleritis in Wegener's granulomatosis after infiximab treatment

Kaarniranta K. 2010. Acta ophthalmologica. 88: e96-97

Switching from a preserved toa preservative-free prostaglandin preparation in topical glaucoma medication

Uusitalo H, Chen E, Pfeiffer N, Brignole-Baudouin F, Kaarniranta K, Leino M, Puska P, Palmgren E, Hamacher T, Hofmann G, Petzold G, Richter U, Riedel T, Winter M & Ropo A. 2010. Acta ophthalmologica. 88: 329-336

Symptom score questionnaire for nasolacrimal duct obstruction in adults - a novel tool to assess the outcome after endoscopic dacryocystorhinostomy

Smirnov G, Tuomilehto H, Kokki H, Kemppainen T, Kiviniemi V, Nuutinen J, Kaarniranta K & Seppä J. 2010. Rhinology. 48: 446-451

p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells

Viiri J, Hyttinen JMT, Ryhänen T, Rilla K, Paimela T, Kuusisto E, Siitonen A, Urtti A, Salminen A & Kaarniranta K. 2010. Molecular vision. 16: 1399-1414

Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors

Kaarniranta K, Salminen A. 2009. Journal of molecular medicine: jmm. 87: 117-123

Cis-urocanic acid suppresses UV-B-induced interleukin-6 and -8 secretion and cytotoxicity in human corneal and conjunctival epithelial cells in vitro

Viiri J, Jauhonen HM, Kauppinen A, Ryhänen T, Paimela T, Hyttinen J, Sorri I, Laihia JK, Leino L, Kaarniranta K. 2009. Molecular vision. 15: 1799-1805

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

Salminen A, Kauppinen A, Suuronen T, Kaarniranta K, Ojala J. 2009. Journal of neuroinflammation. 6: [13 p.]

Efflux protein expression in human retinal pigment epithelium cell lines

Mannermaa E, Vellonen K-S, Ryhänen T, Kokkonen K, Ranta V-P, Kaarniranta K, Urtti A. 2009. Pharmaceutical research. 26: 1785-1791

Heat shock proteins as gatekeepers of proteolytic pathways - Implications for age-related macular generation (AMD)

Kaarniranta K, Salminen A, Eskelinen E-L, Kopitz J. 2009. Ageing research reviews. 8: 128-139

Inflammation in Alzheimer's disease: Amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors

Salminen A, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. 2009. Progress in neurobiology. 87: 181-194

NF-kappaB signaling as a putative target for omega-3 metabolites in the prevention of age-related macular degeneration (AMD)

Kaarniranta K, Salminen A. 2009. Experimental gerontology. 44: 685-688

NF-kappaB signaling in the aging process

Salminen A, Kaarniranta K. 2009. Journal of clinical immunology. 29: 397-405

Regulation of the aging process by autophagy

Salminen A, Kaarniranta K. 2009. Trends in molecular medicine. 15: 217-224

Regulatory role of HIF-1alfa in the pathogenesis of age-related macular degeneration (AMD)

Arjamaa O, Nikinmaa M, Salminen A, Kaarniranta K. 2009. Ageing research reviews. 8: 349-358

Retinal haemorrhages in shaken baby syndrome

Kontkanen M, Kaarniranta K. 2009. Acta ophthalmologica

SIRT1 regulates the ribosomal DNA locus: Epigenetic candles twinkle longevity in the Christmas tree

Salminen A, Kaarniranta K. 2009. Biochemical and biophysical research communications. 378: 6-9

SIRT1: Regulation of longevity via autophagy

Salminen A, Kaarniranta K. 2009. Cellular signalling. 21: 1356-1360

Siglec receptors and hiding plaques in Alzheimer's disease

Salminen A, Kaarniranta K. 2009. Journal of molecular medicine: jmm. 87: 697-701

Silmänpohjan ikärappeuman patogeneesi

Kaarniranta K, Seitsonen S, Paimela T, Meri S, Immonen I. 2009. Duodecim. 125: 145-153

Silmänpohjan ikärappeuman riskitekijät ja hoito

Kaarniranta K, Puustjärvi T, Sorri I. 2009. TERVEYDENHOITOVIESTI, KESKI-SUOMI PIRKANMAA. : s. 16, 29

Single nucleotide polymorphisms of the tenomodulin gene (TNMD) in age-related macular degeneration

Tolppanen A-M, Nevalainen T, Kolehmainen M, Seitsonen S, Immonen I, Uusitupa M, Kaarniranta K, Pulkkinen L, Tolppanen A-M, Kolehmainen M, Uusitupa M, Pulkkinen L. 2009. Molecular vision. 15: 762-770

Vääristyvä kuva silmänpohjan ikärappeumassa - kuinka hoidetaan?

Kaarniranta K. 2009. Lääkärilehti. 64: 3759-3763

Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

Salminen A, Huuskonen J, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. 2008. Ageing research reviews. 7: 83-105

Amyloid-beta oligomers set fire to inflammasomes and induce Alzherimer's pathology

Salminen A, Ojala J, Suuronen T, Kaarniranta K, Kauppinen A. 2008. Journal of cellular and molecular medicine. 12: 2255-2262

Diabeteksen aiheuttamat silmämuutokset

Kaarniranta K, Sorri I. 2008. Lääkärilehti. 63: 621-624

Histopathology of the three implanted degradable biopolymers in rabbit eye

Rönkkö S, Rekonen P, Sihvola R, Kaarniranta K, Puustjärvi T, Teräsvirta M, Uusitalo H. 2008. Journal of biomedical materials research part a. 88: 717-724

In vitro biocompatibility of degradable biopolymers in cell line cultures from various ocular tissues: extraction studies

Huhtala A, Pohjonen T, Salminen L, Salminen A, Kaarniranta K, Uusitalo H. 2008. Journal of materials science: materials in medicine. 19: 645-649

Innate immunity meets with cellular stress at the IKK complex: Regulation of the IKK complex by HSP70 and HSP90

Salminen A, Paimela T, Suuronen T, Kaarniranta K. 2008. Immunology letters. 117: 9-15

Interaction of aging-associated signaling cascades: Inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1

Salminen A, Ojala J, Huuskonen J, Kauppinen A, Suuronen T, Kaarniranta K. 2008. Cellular and molecular life sciences. 65: 1049-1058

Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration

Seitsonen SP, Onkamo P, Peng G, Xiong M, Tommila PV, Ranta PH, Holopainen JM, Moilanen JA, Palosaari T, Kaarniranta K, Meri S, Immonen IR, Järvelä IE. 2008. PLoS ONE. 3: e3833

NEMO shuttle: a link between DNA damage and NF-kappaB activation in progeroid syndromes?

Salminen A, Suuronen T, Huuskonen J, Kaarniranta K. 2008. Biochemical and biophysical research communications. 367: 715-718

Pharmacokinetics, efficacy and safety profiles of preserved and preservative-free tafluprost in healthy volunteers

Uusitalo H, Kaarniranta K, Ropo A. 2008. Acta ophthalmologica. Supplement. 86: 7-13

ROCK, PAK, and Toll of synapses in Alzheimer's disease

Salminen A, Suuronen T, Kaarniranta K. 2008. Biochemical and biophysical research communications. 371: 587-590

Radicicol but not geldanamycin evokes oxidative stress response and efflux protein inhibition in ARPE-19 human retinal pigment epithelial cells

Ryhänen T, Mannermaa E, Oksala N, Viiri J, Paimela T, Salminen A, Atalay M, Kaarniranta K. 2008. European journal of pharmacology. 584: 229-236

Regulation of ERalfa signaling pathway in neuronal HN10 cells: role of protein acetylation and Hsp90

Suuronen T, Ojala J, Hyttinen JMT, Kaarniranta K, Thornell A, Kyrylenko S, Salminen A. 2008. Neurochemical research. 33: 1768-1775

SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation?

Salminen A, Kauppinen A, Suuronen T, Kaarniranta K. 2008. Bioessays. 30: 939-942

Terpenoids: natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential

Salminen A, Lehtonen M, Suuronen T, Kaarniranta K, Huuskonen J. 2008. Cellular and molecular life sciences. 65: 2979-2999

Alpha-lipoic acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney

Oksala NKJ, Lappalainen J, Laaksonen DE, Khanna S, Kaarniranta K, Sen CK, Atalay M. 2007. Antioxidants and redox signaling. 9: 497-506

Corneal epithelium as a platform for secretion of transgene products after transfection with liposomal gene eyedrops

Toropainen E, Hornof M, Kaarniranta K, Johansson P, Urtti A. 2007. Journal of gene medicine. 9: 208-216

Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells

Suuronen T, Nuutinen T, Ryhänen T, Kaarniranta K, Salminen A. 2007. Biochemical and biophysical research communications. 357: 397-401

Imiquimod in the treatment of eyelid basal cell carcinoma

Leppälä J, Kaarniranta K, Uusitalo H, Kontkanen M. 2007. Acta ophthalmologica. 85: 566-568

In vitro biocompatibility of degradable biopolymers in cell line cultures from various ocular tissues:Direct contact studies

Huhtala A, Pohjonen T, Salminen L, Salminen A, Kaarniranta K, Uusitalo H. 2007. Journal of biomedical materials research part a. 83A: 407-413

Leucine 7-proline 7 polymorphism in the signal peptide of neuropeptide Y is not a risk factor for exudative age-related macular degeneration

Kaarniranta K, Holopainen JM , Karvonen MK, Koulu M, Kallio J, Pesonen U, Teräsvirta M, Uusitalo H, Immonen I. 2007. Acta ophthalmologica. 85: 188-191

Maculopathy in Pierre Robin sequences

Kaarniranta K, Tuppurainen K, Nikolajev K. 2007. Journal of pediatric ophthalmology and strabismus

Matrix metalloproteinases and their inhibitors in the chamber angle of normal eyes and patients with primary open-angle glaucoma and exfoliation glaucoma

Rönkkö S, Rekonen P, Kaarniranta K, Puustjärvi T, Teräsvirta M, Uusitalo M. 2007. Graefes archive for clinical and experimental ophthalmology. 245: 697-704

Phospholipase A2 in chamber angle of normal eyes and patients with primary open angle glaucoma and exfoliation glaucoma

Rönkkö S, Rekonen P, Kaarniranta K, Puustjärvi T, Teräsvirta M, Uusitalo H. 2007. Molecular vision. 13: 408-417

Silmänpohjan nesteisen ikärappeuman uudet lääkkeet

Mannermaa E, Urtti A, Kaarniranta K. 2007. Duodecim. 123: 2229-2237

The effect of 17beta-estradiol on IL-6 secretion and NF-kappaB DNA-binding activity in human retinal pigment epithelial cells

Paimela T, Ryhänen T, Mannermaa E, Ojala J, Kalesnykas G, Salminen A, Kaarniranta K, Ojala J. 2007. Immunology letters. 110: 139-144

The expression of heat shock protein 27 in retinal ganglion and glial cells in a rat glaucoma model

Kalesnykas G, Niittykoski M, Rantala J, Miettinen R, Salminen A, Kaarniranta K, Uusitalo H. 2007. Neuroscience. 150: 692-704

A mouse model for Stickler's syndrome: Ocular phenotype of mice carrying a targeted heterozygous inactivation of type II (pro)collagen gene (Col2al)

Kaarniranta K, Ihanamäki T, Sahlman J, Pulkkinen H, Uusitalo H, Arita M, Tammi R, Lammi MJ, Helminen H. 2006. Experimental eye research. 83: 297-303

Analysis of variants in the complement factor H, the elongation of very long chain fatty acids-like 4 and the hemicentin 1 genes of age-related macular degeneration in the Finnish population

Seitsonen S, Lemmelä S, Holopainen J, Tommila P, Ranta P, Kotamies A, Moilanen J, Palosaari T, Kaarniranta K, Meri S, Immonen I, Järvelä I. 2006. Molecular vision. 12: 796-801

Immunolocalization of EMMPRIN (Cd147) in the human eye and detection of soluble form of EMMPRIN in ocular fluids

Määttä M, Tervahartiala T, Kaarniranta K, Tang Y, Yan L, Tuukkanen J, Sorsa T. 2006. Current eye research. 31: 917-924

Geldanamycin activates Hsp70 response and attenuates okadaic acid-induced cytotoxicity in human retinal pigment epithelial cells

Kaarniranta K, Ryhänen T, Sironen RK, Suuronen T, Elo MA, Karjalainen HM, Lammi MJ, Teräsvirta M, Uusitalo H, Salminen A. 2005. MOLECULAR BRAIN RESEARCH. 137: 126-131

Geldanamycin increases 4-hydroxynonenal (HNE)-induced cell death in human retinal pigment epithelial cells

Kaarniranta K, Ryhänen T, Karjalainen HM, Lammi MJ, Suuronen T, Huhtala A, Kontkanen M, Teräsvirta M, Uusitalo H, Salminen A. 2005. Neuroscience letters. 382: 185-190

Hsp90 inhibitor geldanamycin increases hsp70 mRNA stabilisation but fails to activate HSF1 in cells exposed to hydrostatic pressure

Elo MA, Kaarniranta K, Helminen HJ, Lammi MJ. 2005. Biochimica et biophysica acta: molecular cell research. 1743: 115-119

Solustressi yhdistyy silmänpohjan ikärappeumaan

Kaarniranta K. 2005. SILMÄHOITAJA. : 4-5

Hydrostatic pressure-induced changes in cellular protein syntheisis

Lammi MJ, Elo MA, Sironen RK, Karjalainen HM, Kaarniranta K, Helminen HJ. 2004. Biorheology. 41: 309-313

Gene expression profiles in chondrosarcoma cells subjected to cyclic stretching and hydrostatic pressure. A cDNA array study

Karjalainen HM, Sironen RK, Elo MA, Kaarniranta K, Takigawa M, Helminen HJ, Lammi MJ. 2003. Biorheology. 40: 93-100

Silmänpohjan ikärappeuma - vaikea ongelma sekä potilaalle että silmälääkärille

Kaarniranta K, Sihvola R, Salminen A, Lammi MJ, Teräsvirta M, Kontkanen M. 2003. Duodecim. 119: 935-942

Specific induction of heat shock protein 90 beta by high hydrostatic pressure

Elo MA, Sironen RK, Karjalainen HM, Kaarniranta K, Helminen HJ, Lammi MJ. 2003. Biorheology. 40: 141-146

Stress responses of mammalian cells to high hydrostatic pressure

Kaarniranta K, Elo MA, Sironen RK, Karjalainen HM, Helminen HJ, Lammi MJ. 2003. Biorheology. 40: 87-92

High pressure effects on cellular expression profile and mRNA stability. A cDNA array analysis

Sironen RK, Karjalainen HM, Törrönen K, Elo MA, Kaarniranta K, Takigawa M, Helminen HJ, Lammi MJ. 2002. Biorheology. 39: 111-117

Hyaluronan stimulates keratinocyte migration and activates the transcription factor AP-1 in keratinocytes through the JNK pathway

Törrönen K, Yabal M, Rilla K, Kaarniranta K, Tammi R, Lammi MJ, Tammi M. Teoksessa: Kennedy JF, Phillips GO, Williams PA, Hascall VC(toim.) , 2002. Hyaluronan. Chemical, Biochemical and Biological Aspects.. s. 551-556. Woodhead

Neuronal cells show regulatory differences in the hsp70 gene response

Kaarniranta K, Oksala N, Karjalainen HM, Suuronen T, Sistonen L, Helminen HJ, Salminen A, Lammi MJ. 2002. MOLECULAR BRAIN RESEARCH. 101: 136-140

Regulatory Differences of the hsp70 Gene Response in Mammalian Cells

Kaarniranta K. 2002. Kuopio University Publications D. Medical Sciences

cDNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure

Sironen RK, Karjalainen HM, Elo MA, Kaarniranta K, Törrönen K, Takigawa M, Helminen HJ, Lammi MJ. 2002. Biochimica et biophysica acta: molecular cell research. 1591: 45-54

Primary chondrocytes resist hydrostatic pressure-induced stress while primary synovial cells and fibroblasts show modified Hsp70 response

Kaarniranta K, Holmberg CI, Lammi MJ, Eriksson JE, Sistonen L, Helminen HJ. 2001. Osteoarthritis and cartilage. 9: 7-13

Responses of mammalian cells to mechanical forces

Lammi MJ, Sironen RK, Elo MA, Oksala N, Kaarniranta K, Karjalainen HM, Helminen HJ. Teoksessa: Pandalai SG(toim.) , 2001. Recent Research Developments in Biophysics and Biochemistry. s. 77-98. Research Signpost

Solustressin tutkimuksesta kliinisiin läpimurtoihin?

Kaarniranta K, Oksala N, Lammi MJ, Helminen HJ, Sistonen L. 2001. Duodecim. 117: 2266-2272

Differential regulation of stress proteins by high hydrostatic pressure, heat shock, and unbalanced calcium homeostasis in chondrocytis cells

Elo MA, Sironen RK, Kaarniranta K, Auriola S, Helminen HJ, Lammi MJ. 2000. Journal of cellular biochemistry. 79: 610-619

Protein synthesis is required for stabilization of hsp70 mRNA upon exposure to both hydrostatic pressurization and elevated temperature

Kaarniranta K, Holmberg CI, Helminen HJ, Eriksson JE, Sistonen L, Lammi MJ. 2000. Febs letters. 475: 283-286

Transcriptional activation in chondrocytes submitted to hydrostatic pressure

Sironen R, Elo M, Kaarniranta K, Helminen HJ, Lammi MJ. 2000. Biorheology. 37: 85-93

Cytoskeleton and proteoglycan synthesis in chondrocytes under hydrostatic pressure

Parkkinen JJ, Lammi MJ, Jortikka MO, Inkinen RI, Kaarniranta K, Helminen HJ, Tammi MI. Teoksessa: Tanaka S, Hamanishi C(toim.) , 1999. Advances in Osteoarthritis. s. 21-34. Springer

Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation

Kaarniranta K, Elo M, Sironen R, Lammi MJ, Goldring MB, Eriksson JE, Sistonen L, Helminen HJ. 1998. Proceedings of the National Academy of Sciences of the United States of America. 95: 2319-2324

Stage-specific expression and cellular localization of the heat shock factor 2 isoforms in the rat seminiferous epithelium

Alastalo T-P, Lönnström M, Leppä S, Kaarniranta K, Pelto-Huikko M, Sistonen L, Parvinen M. 1998. Experimental cell research. 240: 16-27

Refine your search

Research groups

Projects

A New Generation of Gene Therapies as the Future of Wet AMD Treatment

Acta Ophthalmologica 100 years-Overview of selected articles during Acta Ophthalmologica history

Analysis of prognostic and predictive factors in neovascular age-related macular degeneration Kuopio cohort

Konsensusehdotukset dosentin arvon myöntämiseen liittyvistä käytänteistä ja näkökulmista

PGC‐1α regulates the interplay between oxidative stress, senescence and autophagy in the ageing retina important in age‐related macular degeneration

Silmänpohjan ikärappeuman esiintyminen ja hoitomahdollisuudet

The incidence and prevalence of diabetic macular edema and proliferative diabetic retinopathy, their progression to visual impairment and patterns in their intravitreal treatment in the Finnish population

Tissue fibroblasts are versatile immune regulators: An evaluation of their impact on the aging process

Acta Ophthalmologica for 100 years

Association of APOE Haplotypes With Common Age-Related Ocular Diseases in 412,171 Individuals

Cis-urocanic acid improves cell viability and suppresses inflammasome activation in human retinal pigment epithelial cells

Comparison of barrier properties of outer blood-retinal barrier models - Human stem cell-based models as a novel tool for ocular drug discovery

Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients

Epigallocatechin-3-Gallate, an Active Green Tea Component to Support Anti-VEGFA Therapy in Wet Age-Related Macular Degeneration

Extracellular vesicles in degenerative retinal diseases: A new therapeutic paradigm

FinnGen provides genetic insights from a well-phenotyped isolated population

Geographic atrophy ends Acta Ophthalmologica centennial

Lysosomes in retinal health and disease

Non-Coding RNAs Regulating Mitochondrial Functions and the Oxidative Stress Response as Putative Targets against Age-Related Macular Degeneration (AMD)

Overlap of Genetic Loci for Central Serous Chorioretinopathy With Age-Related Macular Degeneration

Oxidative Stress and Cellular Protein Accumulation Are Present in Keratoconus, Macular Corneal Dystrophy, and Fuchs Endothelial Corneal Dystrophy

The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance

A Linkage between Angiogenesis and Inflammation in Neovascular Age-Related Macular Degeneration

Acta Ophthalmologica 2021

Ajokorttitodistusten näkövaatimukset

Angioid streak

Autophagy in age-related macular degeneration

Bestin tauti

Brolusitsumabi

Computer-based Eye-tracking Analysis of King-Devick Test Differentiates Persons With Idiopathic Normal Pressure Hydrocephalus From Cognitively Unimpaired

Epidemia-ajan erityistoimet silmäpotilailla

Epidemia-ajan kiireellinen ja kiireetön hoito silmätaudeilla

Epoxomicin, a Selective Proteasome Inhibitor, Activates AIM2 Inflammasome in Human Retinal Pigment Epithelium Cells

Etukammionäytteen ja lasiaisnäytteen otto

Fluoreseiiniangiografia (FAG)

Fotodynaaminen hoito (PDT)

Hormetic Heat Shock Enhances Autophagy through HSF1 in Retinal Pigment Epithelium Cells

Hydroquinone increases risk for retinal pigment epithelial (RPE) cell degeneration

Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions

Incidence of cataract surgeries in relation to diagnosis of Parkinson's disease

Indosyaaniinivihreä

Interplay between aging and other factors of the pathogenesis of age-related macular degeneration

Ketotifeeni

Lasiaisinjektion toteutus

Leikkauksenjälkeinen silmämunan sisäosien yleistulehdus

Microglia–Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model

Mikrobinäytteen otto silmästä

Myooppinen degeneraatio

Nature-Inspired Hybrids (NIH) Improve Proteostasis by Activating Nrf2-Mediated Protective Pathways in Retinal Pigment Epithelial Cells

Optic pit -makulopatia

Optinen valokerroskuvaus (OCT)

Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin

Polyyppimainen suonikalvoston rappeuma

Ravistellun vauvan oireyhtymä

Retraction: Hellinen et al. Drug Flux across RPE Cell Models: The Hunt for an Appropriate Outer Blood–Retinal Barrier Model for Use in Early Drug Discovery. Pharmaceutics 2020, 12, 176

Secretory autophagy: a turn key for understanding AMD pathology and developing new therapeutic targets?

Shortening of Saccades as a Possible Easy-to-Use Biomarker to Detect Risk of Alzheimer’s Disease

Siklosporiini

Silmälääkkeet ja niiden vaikutukset

Silmänpohjan ikärappeumat

Silmänvärve (nystagmus)

Silmätautien käsikirja

Sisäsyntyisen silmämunan sisäosien tulehdus

Stargardtin tauti/Fundus flavimaculatus

Telangiekstasiat

The Effect of Dietary Supplementations on Delaying the Progression of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis

Topical treatment of diabetic macular edema using dexamethasone ophthalmic suspension: A randomized, double‐masked, vehicle‐controlled study

Valsalva retinopatia

Verkkokalvo-oksimetri

Verkkokalvohalkio

Verkkokalvon angiomaattinen proliferaatio

Verkkokalvon keskeinen nesteirtauma

Verkkokalvon makroaneurysma

Verkkokalvon reunaosien rappeumat

Visual impairment due to age‐related macular degeneration during 40 years in Finland and the impact of novel therapies

Antimycin A-induced mitochondrial dysfunction regulates inflammasome signaling in human retinal pigment epithelial cells