Kai Kaarniranta
Professor
Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences
kai.kaarniranta@uef.fi
Research groups
Publications
424 items-
Association of APOE Haplotypes With Common Age-Related Ocular Diseases in 412,171 Individuals
Liuska, Perttu J; Rämö, Joel T; Lemmelä, Susanna; Kaarniranta, Kai; Uusitalo, Hannu; Lahtela, Elisa; Daly, Mark J; Harju, Mika; Palotie, Aarno; Turunen, Joni A. 2023. Investigative ophthalmology and visual science. 64: -
Cis-urocanic acid improves cell viability and suppresses inflammasome activation in human retinal pigment epithelial cells
Korhonen, Eveliina; Piippo, Niina; Hytti, Maria; Kaarniranta, Kai; Kauppinen, Anu. 2023. Biochemical pharmacology. 216: -
Comparison of barrier properties of outer blood-retinal barrier models - Human stem cell-based models as a novel tool for ocular drug discovery
Hellinen, Laura; Hongisto, Heidi; Ramsay, Eva; Kaarniranta, Kai; Vellonen, Kati-Sisko; Skottman, Heli; Ruponen, Marika. 2023. European journal of pharmaceutics and biopharmaceutics. 184: 181-188 -
Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients
Karema-Jokinen, Viivi; Koskela, Ali; Hytti, Maria; Hongisto, Heidi; Viheriälä, Taina; Liukkonen, Mikko; Torsti, Tommi; Skottman, Heli; Kauppinen, Anu; Nymark, Soile; Kaarniranta, Kai. 2023. Journal of biological chemistry. 299: -
Epigallocatechin-3-Gallate, an Active Green Tea Component to Support Anti-VEGFA Therapy in Wet Age-Related Macular Degeneration
Blasiak, Janusz; Chojnacki, Jan; Szczepanska, Joanna; Fila, Michal; Chojnacki, Cezary; Kaarniranta, Kai; Pawlowska, Elzbieta. 2023. Nutrients. 15: -
FinnGen provides genetic insights from a well-phenotyped isolated population
Kurki, Mitja I.; Karjalainen, Juha; Palta, Priit; Sipilä, Timo P.; Kristiansson, Kati; Donner, Kati M.; Reeve, Mary P.; Laivuori, Hannele; Aavikko, Mervi; Kaunisto, Mari A.; Loukola, Anu; Lahtela, Elisa; Mattsson, Hannele; Laiho, Päivi; Della Briotta Parolo, Pietro; Lehisto, Arto A.; Kanai, Masahiro; Mars, Nina; Rämö, Joel; Kiiskinen, Tuomo; Heyne, Henrike O.; Veerapen, Kumar; Rüeger, Sina; Lemmelä, Susanna; Zhou, Wei; Ruotsalainen, Sanni; Pärn, Kalle; Hiekkalinna, Tero; Koskelainen, Sami; Paaja. 2023. Nature. 613: 508-518 -
Geographic atrophy ends Acta Ophthalmologica centennial
Kaarniranta, Kai; Stefánsson, Einar. 2023. Acta ophthalmologica. 101: 837-838 -
Lysosomes in retinal health and disease
Boya, Patricia; Kaarniranta, Kai; Handa, James T; Sinha, Debasish. 2023. Trends in neurosciences. 46: 1067-1082 -
Non-Coding RNAs Regulating Mitochondrial Functions and the Oxidative Stress Response as Putative Targets against Age-Related Macular Degeneration (AMD)
Hyttinen, Juha MT; Blasiak, Janusz; Kaarniranta, Kai. 2023. International journal of molecular sciences. 24: -
Overlap of Genetic Loci for Central Serous Chorioretinopathy With Age-Related Macular Degeneration
Rämö, Joel T.; Abner, Erik; van Dijk, Elon HC; Wang, Xin; Brinks, Joost; Nikopensius, Tiit; Nõukas, Margit; Marjonen, Heidi; Silander, Kaisa; Jukarainen, Sakari; Kiiskinen, Tuomo; Choi, Seung Hoan; Kajanne, Risto; Mehtonen, Juha; Palta, Priit; Lubitz, Steven A.; Kaarniranta, Kai; Sobrin, Lucia; Kurki, Mitja; Yzer, Suzanne; Ellinor, Patrick T; Esko, Tõnu; Daly, Mark J; den Hollander, Anneke I; Palotie, Aarno; Turunen, Joni A.; Boon, Camiel JF; Rossin, Elizabeth J; for the FinnGen Study; for the E. 2023. JAMA ophthalmology. 141: 449-457 -
Oxidative Stress and Cellular Protein Accumulation Are Present in Keratoconus, Macular Corneal Dystrophy, and Fuchs Endothelial Corneal Dystrophy
Vottonen, Linda; Koskela, Ali; Felszeghy, Szabolcs; Wylegala, Adam; Kryszan, Katarzyna; Gurubaran, Iswariyaraja Sridevi; Kaarniranta, Kai; Wylegala, Edward. 2023. Journal of clinical medicine. 12: -
The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance
Toppila, Maija; Hytti, Maria; Korhonen, Eveliina; Ranta-aho, Sofia; Harju, Niina; Forsberg, Markus M.; Kaarniranta, Kai; Jalkanen, Aaro; Kauppinen, Anu. 2023. Antioxidants. 12: -
A Linkage between Angiogenesis and Inflammation in Neovascular Age-Related Macular Degeneration
Heloterä, Hanna; Kaarniranta, Kai. 2022. Cells. 11: -
Acta Ophthalmologica 2021
Kaarniranta, Kai; Stefánsson, Einar. 2022. Acta ophthalmologica. 100: 483-485 -
Ajokorttitodistusten näkövaatimukset
Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 680. Kustannus Oy Duodecim -
Angioid streak
Kaarniranta, Kai; Uusitalo-Järvinen, Hannele. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 272-273. Kustannus Oy Duodecim -
Autophagy in age-related macular degeneration
Kaarniranta, Kai; Blasiak, Janusz; Liton, Paloma; Boulton, Michael; Klionsky, Daniel J.; Sinha, Debasish. 2022. Autophagy. 2023; 19: 388-400 -
Bestin tauti
Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 265. Kustannus Oy Duodecim -
Brolusitsumabi
Kaarniranta, Kai; Kajander, Maria. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 773. Kustannus Oy Duodecim -
Computer-based Eye-tracking Analysis of King-Devick Test Differentiates Persons With Idiopathic Normal Pressure Hydrocephalus From Cognitively Unimpaired
Lehtola, Juha-Matti; Kärkkäinen, Virve; Andberg, Sami; Hannonen, Sanna; Rusanen, Minna; Saari, Toni; Korhonen, Ville; Hokkanen, Laura; Hallikainen, Merja; Hänninen, Tuomo; Kaarniranta, Kai; Bednarik, Roman; Leinonen, Ville; Koivisto, Anne M. 2022. Alzheimer disease and associated disorders. 36: 340-346 -
Epidemia-ajan erityistoimet silmäpotilailla
Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 67-68. Kustannus Oy Duodecim -
Epidemia-ajan kiireellinen ja kiireetön hoito silmätaudeilla
Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 59-66. Kustannus Oy Duodecim -
Epoxomicin, a Selective Proteasome Inhibitor, Activates AIM2 Inflammasome in Human Retinal Pigment Epithelium Cells
Sridevi Gurubaran, Iswariyaraja; Hytti, Maria; Kaarniranta, Kai; Kauppinen, Anu. 2022. Antioxidants. 11: -
Etukammionäytteen ja lasiaisnäytteen otto
Kaarniranta, Kai; Marttila, Liisa; Seppänen, Matti. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 631. Kustannus Oy Duodecim -
Fluoreseiiniangiografia (FAG)
Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 579-580. Kustannus Oy Duodecim -
Fotodynaaminen hoito (PDT)
Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 657. Kustannus Oy Duodecim -
Hormetic Heat Shock Enhances Autophagy through HSF1 in Retinal Pigment Epithelium Cells
Amirkavei, Mooud; Plastino, Flavia; Kvanta, Anders; Kaarniranta, Kai; André, Helder; Koskelainen, Ari. 2022. Cells. 11: -
Hydroquinone increases risk for retinal pigment epithelial (RPE) cell degeneration
Bhattarai, Niina; Hytti, Maria; Mysore, Yashavanthi; Kaarniranta, Kai; Kauppinen, Anu. 2022. Acta ophthalmologica -
Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions
Bhattarai, Niina; Hytti, Maria; Reinisalo, Mika; Kaarniranta, Kai; Mysore, Yashavanthi; Kauppinen, Anu. 2022. Immunologic research. 70: 678-687 -
Incidence of cataract surgeries in relation to diagnosis of Parkinson's disease
Lampela, Pasi; Tolppanen, Anna-Maija; Kaarniranta, Kai; Hokkinen, Kaisa; Hartikainen, Sirpa. 2022. Archives of gerontology and geriatrics. 2023; 104: -
Indosyaaniinivihreä
Kivinen, Niko; Kaarniranta, Kai; Kajander, Maria. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 766-767. Kustannus Oy Duodecim -
Interplay between aging and other factors of the pathogenesis of age-related macular degeneration
Blasiak, Janusz; Sobczuk, Piotr; Pawlowska, Elzbieta; Kaarniranta, Kai. 2022. Ageing research reviews. 81: -
Ketotifeeni
Marttila, Liisa; Kivinen, Niko; Kaarniranta, Kai; Seppänen, Matti; Kaustiala, Klaudia. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 755. Kustannus Oy Duodecim -
Lasiaisinjektion toteutus
Kaarniranta, Kai; Seppänen, Matti. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 704-. Kustannus Oy Duodecim -
Leikkauksenjälkeinen silmämunan sisäosien yleistulehdus
Kaarniranta, Kai; Marttila, Liisa; Seppänen, Matti. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 211-215. Kustannus Oy Duodecim -
Microglia–Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model
Boyce, Maeve; Xin, Ying; Chowdhury, Olivia; Shang, Peng; Liu, Haitao; Koontz, Victoria; Strizhakova, Anastasia; Nemani, Mihir; Hose, Stacey; Zigler, J. Samuel; Campbell, Matthew; Sinha, Debasish; Handa, James T.; Kaarniranta, Kai; Qian, Jiang; Ghosh, Sayan. 2022. Cells. 11: -
Mikrobinäytteen otto silmästä
Kaarniranta, Kai, Setälä, Niko. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 627-629. Kustannus Oy Duodecim -
Myooppinen degeneraatio
Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 264-265. Kustannus Oy Duodecim -
Nature-Inspired Hybrids (NIH) Improve Proteostasis by Activating Nrf2-Mediated Protective Pathways in Retinal Pigment Epithelial Cells
Koskela, Ali; Manai, Federico; Basagni, Filippo; Liukkonen, Mikko; Rosini, Michela; Govoni, Stefano; Monte, Massimo Dal; Smedowski, Adrian; Kaarniranta, Kai; Amadio, Marialaura. 2022. Antioxidants. 11: . 1385 -
Optic pit -makulopatia
Kaarniranta, Kai; Seppänen, Matti. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 385-386. Kustannus Oy Duodecim -
Optinen valokerroskuvaus (OCT)
Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 583-594. Kustannus Oy Duodecim -
Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2022. Inflammation research. 71: 817-831 -
Polyyppimainen suonikalvoston rappeuma
Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 260. Kustannus Oy Duodecim -
Ravistellun vauvan oireyhtymä
Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 523-524. Kustannus Oy Duodecim -
Retraction: Hellinen et al. Drug Flux across RPE Cell Models: The Hunt for an Appropriate Outer Blood–Retinal Barrier Model for Use in Early Drug Discovery. Pharmaceutics 2020, 12, 176
Hellinen, Laura; Hongisto, Heidi; Ramsay, Eva; Kaarniranta, Kai; Vellonen, Kati-Sisko; Skottman, Heli; Ruponen, Marika. 2022. Pharmaceutics. 14: 595 -
Secretory autophagy: a turn key for understanding AMD pathology and developing new therapeutic targets?
Blasiak, Janusz; Kaarniranta, Kai. 2022. Expert opinion on therapeutic targets. 26: 883-895 -
Shortening of Saccades as a Possible Easy-to-Use Biomarker to Detect Risk of Alzheimer’s Disease
Hannonen, Sanna; Andberg, Sami; Kärkkäinen, Virve; Rusanen, Minna; Lehtola, Juha-Matti; Saari, Toni; Korhonen, Ville; Hokkanen, Laura; Hallikainen, Merja; Hänninen, Tuomo; Leinonen, Ville; Kaarniranta, Kai; Bednarik, Roman; Koivisto, Anne M.. 2022. Journal of Alzheimer's disease. 88: 609-618 -
Siklosporiini
Seppänen, Matti; Kaarniranta, Kai; Kajander, Maria. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 777-778. Kustannus Oy Duodecim -
Silmälääkkeet ja niiden vaikutukset
Hautala, Nina; Kaarniranta, Kai; Uusitalo, Hannu. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 699-702. Kustannus Oy Duodecim -
Silmänpohjan ikärappeumat
Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 257-259. Kustannus Oy Duodecim -
Silmänvärve (nystagmus)
Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 395. Kustannus Oy Duodecim -
Silmätautien käsikirja
Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. 2022. . 3., uudistettu painos. Kustannus Oy Duodecim -
Sisäsyntyisen silmämunan sisäosien tulehdus
Marttila, Liisa; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 215-216. Kustannus Oy Duodecim -
Stargardtin tauti/Fundus flavimaculatus
Kaarniranta, Kai; Seppänen, Matti. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 266-267. Kustannus Oy Duodecim -
Telangiekstasiat
Kaarniranta, Kai; Setälä, Niko. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 273-274. Kustannus Oy Duodecim -
The Effect of Dietary Supplementations on Delaying the Progression of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis
Csader, Susanne; Korhonen, Sonja; Kaarniranta, Kai; Schwab, Ursula. 2022. Nutrients. 14: -
Topical treatment of diabetic macular edema using dexamethasone ophthalmic suspension: A randomized, double‐masked, vehicle‐controlled study
Stefansson, Einar; Loftsson, Thorstein; Larsen, Michael; Papp, András; Kaarniranta, Kai; Munk, Marion R.; Dugel, Pravin; Tadayoni, Ramin. 2022. Acta ophthalmologica. 2023; 101: 22-33 -
Valsalva retinopatia
Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 276. Kustannus Oy Duodecim -
Verkkokalvo-oksimetri
Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 583. Kustannus Oy Duodecim -
Verkkokalvohalkio
Kaarniranta, Kai; Marttila, Liisa. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 281-282. Kustannus Oy Duodecim -
Verkkokalvon angiomaattinen proliferaatio
Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 261-262. Kustannus Oy Duodecim -
Verkkokalvon keskeinen nesteirtauma
Kivinen, Niko; Kaarniranta, Kai; Seppänen Matti. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 262-264. Kustannus Oy Duodecim -
Verkkokalvon makroaneurysma
Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 274-275. Kustannus Oy Duodecim -
Verkkokalvon reunaosien rappeumat
Marttila, Liisa, Kaarniranta, Kai . Teoksessa: Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2022. Silmätautien käsikirja. s. 282-284. Kustannus Oy Duodecim -
Visual impairment due to age‐related macular degeneration during 40 years in Finland and the impact of novel therapies
Purola, Petri; Kaarniranta, Kai; Ojamo, Matti; Gissler, Mika; Uusitalo, Hannu. 2022. Acta ophthalmologica. 2023; 101: 57-64 -
Antimycin A-induced mitochondrial dysfunction regulates inflammasome signaling in human retinal pigment epithelial cells
Korhonen, Eveliina; Hytti, Maria; Piippo, Niina; Kaarniranta, Kai; Kauppinen, Anu. 2021. Experimental eye research. 209: 108687 -
Association of the MYOC p.(Gln368Ter) Variant With Glaucoma in a Finnish Population
Liuska, PJ; Lemmelä, S; Havulinna, AS; Kaarniranta, K; Uusitalo, H; Laivuori, H; Kiiskinen, T; Daly, MJ; Palotie, A; Turunen, JA. 2021. JAMA ophthalmology. 139: 762-768 -
Differential Expression of Inflammasome-Related Genes in Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells with or without History of Age-Related Macular Degeneration
Hytti, Maria; Korhonen, Eveliina; Hongisto, Heidi; Kaarniranta, Kai; Skottman, Heli; Kauppinen, Anu. 2021. International journal of molecular sciences. 22: 6800 -
Dysregulated Tear Film Proteins in Macular Edema Due to the Neovascular Age-Related Macular Degeneration Are Involved in the Regulation of Protein Clearance, Inflammation, and Neovascularization
Winiarczyk, Mateusz; Winiarczyk, Dagmara; Michalak, Katarzyna; Kaarniranta, Kai; Adaszek, Lukasz; Winiarczyk, Stanislaw; Mackiewicz, Jerzy. 2021. Journal of clinical medicine. 10: 3060 -
Effect of cataract surgery on wet age-related macular degeneration activity
Karesvuo, Petteri; Elbaz, Uri; Achiron, Asaf; Hecht, Idan; Kaarniranta, Kai; Tuuminen, Raimo. 2021. Acta ophthalmologica. 2022; 100: e262-e269 -
Effects of Resvega on Inflammasome Activation in Conjunction with Dysfunctional Intracellular Clearance in Retinal Pigment Epithelial (RPE) Cells
Bhattarai, Niina; Piippo, Niina; Ranta-aho, Sofia; Mysore, Yashavanthi; Kaarniranta, Kai; Kauppinen, Anu. 2021. Antioxidants. 10: 67 -
Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice
Blasiak, Janusz; Koskela, Ali; Pawlowska, Elzbieta; Liukkonen, Mikko; Ruuth, Johanna; Toropainen, Elisa; Hyttinen, Juha MT; Viiri, Johanna; Eriksson, John E.; Xu, Heping; Chen, Mei; Felszeghy, Szabolcs; Kaarniranta, Kai. 2021. International journal of molecular sciences. 22: 1684 -
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Klionsky, Daniel J; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; Abildgaard, Marie H; Abudu, Yakubu Princely; Acevedo-Arozena, Abraham; Adamopoulos, Iannis E; Adeli, Khosrow; Adolph, Timon E; Adornetto, Annagrazia; Aflaki, Elma; Agam, Galila; Agarwal, Anupam; Aggarwal, Bharat B; Agnello, Maria; Agostinis, Patrizia et al. [Incl. Haapasalo, Annakaisa; Leskelä, Stina; Kaarniranta, Kai; Kauppinen, Anu; Koskela, Ali]. 2021. Autophagy. 17: 1-382 -
Hydroquinone Induces NLRP3-Independent IL-18 Release from ARPE-19 Cells
Bhattarai, Niina; Korhonen, Eveliina; Mysore, Yashavanthi; Kaarniranta, Kai; Kauppinen, Anu. 2021. Cells. 10: 1405 -
Hypoxia/ischemia impairs CD33 (Siglec-3)/TREM2 signaling: Potential role in Alzheimer's pathogenesis
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2021. Neurochemistry international. 150: 105186 -
Incidence of cataract surgeries in people with and without Alzheimer's disease
Hokkinen, K; Kaarniranta, K; Jämsen, E; Lampela, P; Hartikainen, S; Tolppanen, AM. 2021. Acta ophthalmologica. 2022; 100: 68-73 -
Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration
Hellinen, Laura; Koskela, Ali; Vattulainen, Elina; Liukkonen, Mikko; Wegler, Christine; Treyer, Andrea; Handin, Niklas; Svensson, Richard; Myöhänen, Timo; Poso, Antti; Kaarniranta, Kai; Artursson, Per; Urtti, Arto. 2021. Biomedicine and pharmacotherapy. 2022; 146: 112501 -
Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2021. Inflammation research. 70: 1043-1061 -
Lasiaisinjektiot mullistivat silmänpohjan kostean ikärappeuman hoidon
Kivinen, Niko; Kaarniranta, Kai. 2021. Lääkärilehti. 76: 2055-2058 -
MicroRNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy
Hyttinen, Juha M T; Blasiak, Janusz; Felszeghy, Szabolcs; Kaarniranta, Kai. 2021. Ageing research reviews. 67: 101260 -
Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1[alpha] -/- Mouse Model Evoke Complement Component C5a Independent of C3
Sridevi Gurubaran, Iswariyaraja; Heloterä, Hanna; Marry, Stephen; Koskela, Ali; Hyttinen, Juha MT; Paterno, Jussi J; Urtti, Arto; Chen, Mei; Xu, Heping; Kauppinen, Anu; Kaarniranta, Kai. 2021. Biology. 10: 622 -
Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice
Tamminen, Toni; Koskela, Ali; Toropainen, Elisa; Gurubaran, Iswariyaraja Sridevi; Winiarczyk, Mateusz; Liukkonen, Mikko; Paterno, Jussi J; Lackman, Petri; Sadeghi, Amir; Viiri, Johanna; Hyttinen, Juha MT; Koskelainen, Ari; Kaarniranta, Kai. 2021. Oxidative medicine and cellular longevity. 2021: -
Potential of Long Non-Coding RNAs in Age-Related Macular Degeneration
Blasiak, Janusz; Hyttinen, Juha M. T.; Szczepanska, Joanna; Pawlowska, Elzbieta; Kaarniranta, Kai. 2021. International journal of molecular sciences. 22: 9178 -
Potential of Telomerase in Age-Related Macular Degeneration-Involvement of Senescence, DNA Damage Response and Autophagy and a Key Role of PGC-1α
Blasiak, J; Szczepanska, J; Fila, M; Pawlowska, E; Kaarniranta, K. 2021. International journal of molecular sciences. 22: 7194 -
Serum Levels of Plasmalogens and Fatty Acid Metabolites Associate with Retinal Microangiopathy in Participants from the Finnish Diabetes Prevention Study
de Mello, Vanessa Derenji; Selander, Tuomas; Lindström, Jaana; Tuomilehto, Jaakko; Uusitupa, Matti; Kaarniranta, Kai. 2021. Nutrients. 13: 4452 -
Successful years of collaboration between Acta Ophthalmologica and the European Association for Vision and Eye Research
Kaarniranta, Kai; Stefansson, Einar. 2021. Acta ophthalmologica. 99: 239 -
TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells
Ranta-aho, Sofia; Piippo, Niina; Korhonen, Eveliina; Kaarniranta, Kai; Hytti, Maria; Kauppinen, Anu. 2021. International journal of molecular sciences. 22: 4875 -
The most successful year in the history of Acta Ophthalmologica
Kaarniranta, Kai; Stefánsson, Einar. 2021. Acta ophthalmologica. 99: 117-117 -
The state of your journal Acta Ophthalmologica 2020
Kaarniranta, Kai; Stefánsson, Einar. 2021. Acta ophthalmologica. 99: 467-469 -
Therapeutic potential of PGC-1α in age-related macular degeneration (AMD) - the involvement of mitochondrial quality control, autophagy, and antioxidant response
Hyttinen, Juha; Blasiak, Janusz; Tavi, Pasi; Kaarniranta, Kai. 2021. Expert opinion on therapeutic targets. 25: 773-785 -
Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application
Rousou, Charis; Schuurmans, Carl C. L.; Urtti, Arto; Mastrobattista, Enrico; Storm, Gert; Moonen, Chrit; Kaarniranta, Kai; Deckers, Roel. 2021. Pharmaceutics. 13: 1782 -
Autophagy Genes for Wet Age-Related Macular Degeneration in a Finnish Case-Control Study
Paterno, Jussi J; Koskela, Ali; Hyttinen, Juha M T; Vattulainen, Elina; Synowiec, Ewelina; Tuuminen, Raimo; Watala, Cezary; Blasiak, Janusz; Kaarniranta, Kai. 2020. Genes. 11: 1318 -
Comparison of Two Different Treat-and-Extend Protocols with Afibercept in Wet Age-Related Macular Degeneration: Two-Year Results
Taipale, Claudia; Lindholm, Juha-Matti; Kaarniranta, Kai; Tuuminen, Raimo. 2020. Advances in therapy. 37: 2256-2266 -
Correlation Between the Rate of Intravitreal Injections, Use of Aflibercept as a Second-Line Treatment and Visual Impairment for Wet AMD in Finland
Karesvuo, Petteri; Hakkala, Laura; Kaarniranta, Kai; Uusitalo, Hannu; Ojamo, Matti; Tuuminen, Raimo. 2020. Acta ophthalmologica. 98: 472-476 -
DICER1 in the Pathogenesis of Age-related Macular Degeneration (AMD) - Alu RNA Accumulation versus miRNA Dysregulation
Kaarniranta, Kai; Pawlowska, Elzbieta; Szczepanska, Joanna; Blasiak, Janusz. 2020. Aging and disease. 11: 851-862 -
Drug Flux Across RPE Cell Models: The Hunt for An Appropriate Outer Blood-Retinal Barrier Model for Use in Early Drug Discovery
Hellinen, Laura; Hongisto, Heidi; Ramsay, Eva; Kaarniranta, Kai; Vellonen, Kati-Sisko; Skottman, Heli; Ruponen, Marika. 2020. Pharmaceutics. 12: 176 -
ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2020. Journal of molecular medicine: jmm. 98: 633-650 -
Exosomal vesicles enhance immunosuppression in chronic inflammation: Impact in cellular senescence and the aging process
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2020. Cellular signalling. 75: 109771 -
Immunological biomarkers of the vitreous responsible for proliferative alteration in the different forms of retinal detachment
Balogh, Anikó; Milibák, Tibor; Szabó, Viktória; Nagy, Zoltán Zsolt; Kaarniranta, Kai; Resch, Miklós D. 2020. Bmc ophthalmology. 20: 491 -
In vitro stem cell modelling demonstrates a proof-of-concept for excess functional mutant TIMP3 as the cause of Sorsby Fundus Dystrophy
Hongisto, H; Dewing, JM; Christensen, DRG; Scott, J; Cree, AJ; Nättinen, J; Määttä, J; Jylhä, A; Aapola, U; Uusitalo, H; Kaarniranta, K; Ratnayaka, JA; Skottman, H; Lotery, AJ. 2020. Journal of pathology. 252: 138-150 -
Induction of Heat Shock Protein 70 in Mouse RPE as an In Vivo Model of Transpupillary Thermal Stimulation
Amirkavei, Mooud; Pitkänen, Marja; Kaikkonen, Ossi; Kaarniranta, Kai; André, Helder; Koskelainen, Ari. 2020. International journal of molecular sciences. 21: 2063 -
Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration
Kaarniranta, Kai; Uusitalo, Hannu; Blasiak, Janusz; Felszeghy, Szabolcs; Kannan, Ram; Kauppinen, Anu; Salminen, Antero; Sinha, Debasish; Ferrington, Deborah. 2020. Progress in retinal and eye research. 78: 100858 -
Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model
Sridevi Gurubaran, Iswariyaraja; Viiri, Johanna; Koskela, Ali; Hyttinen, Juha M; Paterno, Jussi; Kis, Gréta; Antal, Miklós; Urtti, Arto; Kauppinen, Anu; Felszeghy, Szabolcs; Kaarniranta, Kai. 2020. International journal of molecular sciences. 21: 1976 -
Only IL-1ß release is inflammasome-dependent upon ultraviolet B irradiation although IL-18 is also secreted
Korhonen, Eveliina; Piippo, Niina; Hytti, Maria; Hyttinen, Juha; Kaarniranta, Kai; Kauppinen, Anu. 2020. Faseb journal. 34: 6437-6448 -
Potential Role of Myeloid-Derived Suppressor Cells (MDSCs) in Age-Related Macular Degeneration (AMD)
Kauppinen, Anu; Kaarniranta, Kai; Salminen, Antero. 2020. Frontiers in immunology. 11: 384 -
Resvega Alleviates Hydroquinone-Induced Oxidative Stress in ARPE-19 Cells
Bhattarai, Niina; Korhonen, Eveliina; Toppila, Maija; Koskela, Ali; Kaarniranta, Kai; Mysore, Yashavanthi; Kauppinen, Anu. 2020. International journal of molecular sciences. 21: 2066 -
Resveratrol as Inducer of Autophagy, Pro-Survival, and Anti-Inflammatory Stimuli in Cultured Human RPE Cells
Josifovska, N; Albert, R; Nagymihály, R; Lytvynchuk, L; Moe, MC; Kaarniranta, K; Veréb, ZJ; Petrovski, G. 2020. International journal of molecular sciences. 21: 813 -
The Aging Stress Response and Its Implication for AMD Pathogenesis
Blasiak, Janusz; Pawlowska, Elzbieta; Sobczuk, Anna; Szczepanska, Joanna; Kaarniranta, Kai. 2020. International journal of molecular sciences. 21: 8840 -
The role of vision-related problems in fatal road accidents in Finland
Wedenoja, Juho; Kalsi, Juhani; Salenius, Salla; Parkkari, Kalle; Kaarniranta, Kai; Tervo, Timo. 2020. Acta ophthalmologica. 2021; 99: 427-430 -
Trehalose for Ocular Surface Health
Laihia, Jarmo; Kaarniranta, Kai. 2020. Biomolecules. 10: 809 -
UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells
Korhonen, Eveliina; Bisevac, Jovana; Hyttinen, Juha MT; Piippo, Niina; Hytti, Maria; Kaarniranta, Kai; Petrovski, Goran; Kauppinen, Anu. 2020. Investigative ophthalmology and visual science. 61: 7 -
Yhtenäiset vaatimukset lääketieteen ja hammaslääketieteen tohtorintutkinnolle Suomessa
Lehenkari, Petri; Tuovinen, Timo; Alahuhta, Seppo; Risteli, Leila; Ylöstalo, Pekka; Rämet, Mika; Parkkila, Seppo; Happo, Saara; Kaarniranta, Kai; Blom, Nina; Ritvos, Olli; Kähäri, Veli-Matti; Leivo, Ilmo; Heikinheimo, Markku. 2020. Duodecim. 136: 633-640 -
Zinc and Autophagy in Age-Related Macular Degeneration
Blasiak, Janusz; Pawlowska, Elzbieta; Chojnacki, Jan; Szczepanska, Joanna; Chojnacki, Cezary; Kaarniranta, Kai. 2020. International journal of molecular sciences. 21: 4994 -
AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging
Salminen, Antero; Kauppinen, Anu; Kaarniranta, Kai. 2019. Journal of molecular medicine: jmm. 97: 1049-1064 -
Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy
Hytti, Maria; Korhonen, Eveliina; Hyttinen, Juha M T; Roehrich, Heidi; Kaarniranta, Kai; Ferrington, Deborah A; Kauppinen, Anu. 2019. Oxidative medicine and cellular longevity. 2019: 1583656 -
Can vitamin D protect against age-related macular degeneration or slow its progression?
Kaarniranta, K; Pawlowska, E; Szczepanska, J; Jablkowska, A; Blasiak, J. 2019. Acta biochimica polonica. 66: 147-158 -
Changes in ocular signs and symptoms in patients switching from bimatoprost-timolol to tafluprost-timolol eye drops: an open-label phase IV study
Bourne, RRA; Kaarniranta, K; Lorenz, K; Traverso, CE; Vuorinen, J; Ropo, A. 2019. BMJ open. 9: e024129 -
Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients
Kiamehr, M; Klettner, A; Richert, E; Koskela, A; Koistinen, A; Skottman, H; Kaarniranta, K; Aalto-Setälä, K; Juuti-Uusitalo, K. 2019. International journal of molecular sciences. 20: 3773 -
Dietary Polyphenols in Age-Related Macular Degeneration: Protection against Oxidative Stress and Beyond
Pawlowska, E; Szczepanska, J; Koskela, A; Kaarniranta, K; Blasiak, J. 2019. Oxidative medicine and cellular longevity. 2019: 9682318 -
Disease aetiology-based design of multifunctional microemulsion eye drops for moderate or severe dry eye: a randomized, quadruple-masked and active-controlled clinical trial
Laihia, J; Järvinen, R; Wylegala, E; Kaarniranta, K. 2019. Acta ophthalmologica. 2020; 98: 244-254 -
Electrical synapses interconnecting axons revealed in the optic nerve head - a novel model of gap junctions' involvement in optic nerve function
Smedowski, A; Akhtar, S; Liu, X; Pietrucha-Dutczak, M; Podracka, L; Toropainen, E; Alkanaan, A; Ruponen, M; Urtti, A; Varjosalo, M; Kaarniranta, K; Lewin-Kowalik, J. 2019. Acta ophthalmologica. [Epub ahead of print 10 Oct 2019]: 1-10 -
Expression of VEGFA-regulating miRNAs and mortality in wet AMD
Blasiak, J; Watala, C; Tuuminen, R; Kivinen, N; Koskela, A; Uusitalo-Järvinen, H; Tuulonen, A; Winiarczyk, M; Mackiewicz, J; Zmorzynski, S; Filip, A; Kaarniranta, K. 2019. Journal of cellular and molecular medicine. 23: 8464-8471 -
Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration
Kaarniranta, Kai; Koskela, Ali; Felszeghy, Szabolcs; Kivinen, Niko; Salminen, Antero; Kauppinen, Aanu. 2019. Biochimie. 159: 49-54 -
Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium-Role in Dead Cell Clearance and Inflammation
Szatmári-Tóth, M; Ilmarinen, T; Mikhailova, A; Skottman, H; Kauppinen, A; Kaarniranta, K; Kristóf, E; Lytvynchuk, L; Veréb, Z; Fésüs, L; Petrovski, G. 2019. International journal of molecular sciences. 20: 926 -
Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2019. Cellular and molecular life sciences. 76: 1901-1918 -
Interplay between Autophagy and the Ubiquitin-Proteasome System and Its Role in the Pathogenesis of Age-Related Macular Degeneration
Blasiak, J; Pawlowska, E; Szczepanska, J; Kaarniranta, K. 2019. International journal of molecular sciences. 20: 210 -
Life Style Intervention Improves Retinopathy Status - The Finnish Diabetes Prevention Study
Aro, A; Kauppinen, A; Kivinen, N; Selander, T; Kinnunen, K; Tuomilehto, J; Keinänen-Kiukaanniemi, S; Lindström, J; Uusitupa, M; Kaarniranta, K. 2019. Nutrients. 11: 1691 -
Real Life Experience of Dexamethasone Implant in Refractory Diabetic Macular Oedema
Karttunen, Tommi; Nummelin, Lasse; Kaarniranta, Kai; Kinnunen, Kati. 2019. Clinical ophthalmology. 13: 2583-2590 -
Resvega alleviates oxidative stress and inflammasome activation in retinal pigment epithelial cells
Bhattarai, Niina; Korhonen, Eveliina; Toppila, Maija; Kaarniranta, Kai; Kauppinen, Anu. 2019. Acta ophthalmologica -
Role of Mitochondrial DNA Damage in ROS-Mediated Pathogenesis of Age-Related Macular Degeneration (AMD).
Kaarniranta, K; Pawlowska, E; Szczepanska, J; Jablkowska, A; Blasiak, J. 2019. International journal of molecular sciences. 20: 2374 -
SQSTM1/p62 regulates the production of IL-8 and MCP-1 in IL-1ß-stimulated human retinal pigment epithelial cells
Korhonen, E; Piippo, N; Hytti, M; Hyttinen, JMT; Kaarniranta, K; Kauppinen, A. 2019. Cytokine. 116: 70-77 -
Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage
Zeiner, J; Loukovaara, S; Losenkova, K; Zuccarini, M; Korhonen, AM; Lehti, K; Kauppinen, A; Kaarniranta, K; Müller, CE; Jalkanen, S; Yegutkin, GG. 2019. Journal of molecular medicine: jmm. 97: 341-354 -
The Regulation of NFE2L2 (NRF2) Signalling and Epithelial-to-Mesenchymal Transition in Age-Related Macular Degeneration Pathology
Hyttinen, JMT; Kannan, R; Felszeghy, S; Niittykoski, M; Salminen, A; Kaarniranta, K. 2019. International journal of molecular sciences. 20: 5800 -
The first ophthalmic Choosing Wisely recommendations in Finland for glaucoma and wet age-related macular degeneration
Tuuminen, R; Sipilä, R; Komulainen, J; Saarela, V; Kaarniranta, K; Tuulonen, A. 2019. Acta ophthalmologica. 97: e808-e810 -
Ajokorttitodistusten näkövaatimukset
Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 376. Duodecim -
Asikloviiri
Seppänen, Matti; Setälä, Niko; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 433-434. Duodecim -
Atselastiini
Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 469. Duodecim -
Atsitromysiini
Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 434. Duodecim -
Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways
Marchesi, Nicoletta; Thongon, Natthakan; Pascale, Alessia; Provenzani, Alessandro; Koskela, Ali; Korhonen, Eveliina; Smedowski, Adrian; Govoni, Stefano; Kauppinen, Anu; Kaarniranta, Kai; Amadio, Marialaura. 2018. Oxidative medicine and cellular longevity. 2018: 4956080 -
Bestin tauti
Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 194-195. Duodecim -
Dinatriumkromoglikaatti
Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 470-471. Duodecim -
Emedastiini
Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 470. Duodecim -
Fluoreseiiniangiografia (FAG)
Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 394-395. Duodecim -
Fluorokinolonit
Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 434-435. Duodecim -
Fotodynaaminen hoito (PDT)
Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 422. Duodecim -
Fusidiinihappo
Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 435-436. Duodecim -
Gansikloviiri
Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 436-437. Duodecim -
Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome
Piippo, N; Korhonen, E; Hytti, M; Skottman, H; Kinnunen, K; Josifovska, N; Petrovski, G; Kaarniranta, K; Kauppinen, A. 2018. Scientific reports. 8: 6720 -
Kefuroksiimi
Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 437. Duodecim -
Klooritetrasykliini
Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 437-438. Duodecim -
Kloramfenikoli
Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 438-439. Duodecim -
Leikkauksenjälkeisen silmämunan sisäosien yleistulehduksen hoito
Kaarniranta, Kai; Marttila, Liisa; Seppänen, Matti. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 185-188. Duodecim -
Levokabastiini
Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 471-472. Duodecim -
Lodoksamidi
Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 472. Duodecim -
Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. 2018. Redox biology. 2019; 20: 1-12 -
Mechanistical retinal drug targets and challenges
Kaarniranta; Kai; Xu, Heping; Kauppinen, Anu. 2018. Advanced drug delivery reviews. 126: 177-184 -
Mikrobinäytteen otto silmästä
Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 407-409. Duodecim -
Mitochondrial quality control in AMD: does mitophagy play a pivotal role?
Hyttinen, Juha MT; Viiri, Johanna; Kaarniranta, Kai; Blasiak, Janusz. 2018. Cellular and molecular life sciences. 75: 2991-3008 -
Molecular Mechanisms Underlying Age-Related Ocular Diseases
Amadio, Marialaura; Kaarniranta, Kai; Xu, Heping; Smedowski, Adrian; Ferrington, Deborah A. 2018. Oxidative medicine and cellular longevity. 2018: 1-2 -
Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence
Salminen, Antero; Kauppinen, Anu; Kaarniranta, Kai. 2018. Biogerontology. 19: 325-329 -
Natamysiini
Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 439-440. Duodecim -
Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolemic mice
Ruotsalainen, Anna-Kaisa; Lappalainen, Jari P; Heiskanen, Emmi; Merentie, Mari; Näpänkangas, Juha; Lottonen-Raikaslehto, Line; Kansanen, Emilia; Adinolfi, Simone; Kaarniranta, Kai; Ylä-Herttuala, Seppo; Jauhiainen, Matti; Pirinen, Eija; Levonen, Anna-Liisa. 2018. Cardiovascular research. 2019; 115: 243-254 -
Olopatadiini
Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 472-473. Duodecim -
Optinen valokerroskuvaus (OCT)
Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 396-397. Duodecim -
Oxidative Stress is the Principal Contributor to Inflammasome Activation in Retinal Pigment Epithelium Cells with Defunct Proteasomes and Autophagy
Piippo, Niina; Korhonen, Eveliina; Hytti, Maria; Kinnunen, Kati; Kaarniranta, Kai; Kauppinen, Anu. 2018. Cellular physiology and biochemistry. 49: 359-367 -
PGC-1alfa Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD Pathogenesis
Kaarniranta, Kai; Kajdanek, Jakub; Morawiec, Jan; Pawlowska, Elzbieta; Blasiak, Janusz. 2018. International journal of molecular sciences. 19: 2317 -
Phytochemicals inhibit the immunosuppressive functions of myeloid-derived suppressor cells (MDSC): Impact on cancer and age-related chronic inflammatory disorders.
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2018. International immunopharmacology. 61: 231-240 -
Propamidiini
Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 440. Duodecim -
Seroosi retinopatia, nesteinen keskeisen verkkokalvon sairaus
Kivinen, Niko; Kaarniranta, Kai. 2018. Lääkärilehti. 73: 1940-1943 -
Siklosporiini
Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 480-481. Duodecim -
Silmänpohjan ikärappeumat
Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 192-194. Duodecim -
Silmänpohjan kuvantaminen yleistyy ja tarkentuu
Kivinen, Niko; Tuulonen, Anja; Kaarniranta, Kai. 2018. Duodecim. 134: 1235-1243 -
Silmätautien käsikirja
Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. 2018. . . Duodecim -
Silmävärve (nystagmus)
Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 290-291. Duodecim -
Special issue on Molecular Mechanisms Underlying Age-Related Ocular Diseases
Amadio, Marialaura; Kaarniranta, Kai; Xu, Heping; Smedowski, Adrian; Ferrington, Deborah A. 2018. Oxidative medicine and cellular longevity. . Hindawi publishing corporation -
Suppressed heat shock protein response in the kidney of exercise-trained diabetic rats
Lappalainen, J; Oksala, NKJ; Laaksonen, DE; Khanna, S; Kokkola, T; Kaarniranta, K; Sen, CK; Atalay, M. 2018. Scandinavian journal of medicine and science in sports. 28: 1808-1817 -
Survival and functionality of xeno-free human embryonic stem cell-derived retinal pigment epithelial cells on polyester substrate after transplantation in rabbits
Ilmarinen, T; Thieltges, F; Hongisto, H; Juuti-Uusitalo, K; Koistinen, A; Kaarniranta, K; Brinken, R; Braun, N; Holz, FG; Skottman, H; Stanzel, BV. 2018. Acta ophthalmologica. 2019; 97: e688-e699 -
Tear film proteome in age-related macular degeneration
Winiarczyk, Mateusz; Kaarniranta, Kai; Winiarczyk, Stanislaw; Adaszek, Lukasz; Winiarczyk, Dagmara; Mackiewicz, Jerzy. 2018. Graefes archive for clinical and experimental ophthalmology. 256: 1127-1139 -
The potential importance of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of Alzheimer's disease
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2018. Cellular and molecular life sciences. 75: 3099-3120 -
The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2018. Ageing research reviews. 48: 1-10 -
Tobramysiini
Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 440-441. Duodecim -
Verkkokalvohalkio
Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 182-183. Duodecim -
Verkkokalvon keskeinen nesteirtauma
Kivinen, Niko; Kaarniranta, Kai; Seppänen, Matti. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu(toim.) , 2018. Silmätautien käsikirja. s. 184-185. Duodecim -
Wound healing of human embryonic stem cell-derived retinal pigment epithelial cells is affected by maturation stage
Khamidakh, Amna E Abu; Rodriguez-Martinez, Alejandra; Kaarniranta, Kai; Kallioniemi, Anne; Skottman, Heli; Hyttinen, Jari; Juuti-Uusitalo, Kati. 2018. Biomedical engineering online. 17: 102 -
Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells
Juuti-Uusitalo K, Koskela A, Kivinen N, Viiri J, Hyttinen JMT, Reinisalo M, Koistinen A, Uusitalo H, Sinha D, Skottman H, Kaarniranta K. 2017. International journal of molecular sciences. 18: 1089 -
CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells
Hytti M, Andjelic S, Josifovska N, Piippo N, Korhonen E, Hawlina M, Kaarniranta K, Nevalainen TJ, Petrovski G, Parkkari T, Kauppinen A. 2017. Scientific reports. 7: 16169 -
Cellular Senescence in Age-Related Macular Degeneration: Can Autophagy and DNA Damage Response Play a Role?
Blasiak Janusz, Piechota Malgorzata, Pawlowska Elzbieta, Szatkowska Magdalena, Sikora Ewa, Kaarniranta Kai. 2017. Oxidative medicine and cellular longevity. 2017: 5293258 -
Contacting co-culture of human retinal microvascular endothelial cells alters barrier function of human embryonic stem cell derived retinal pigment epithelial cells
Skottman H, Muranen J, Lähdekorpi H, Pajula E, Mäkelä K, Koivusalo L, Koistinen A, Uusitalo H, Kaarniranta K, Juuti-Uusitalo K. 2017. Experimental cell research. 359: 101-111 -
Cytoarchitecture of epithelial inflammatory infiltration indicates the aetiology of infectious keratitis
Smedowski A, Tarnawska D, Orski M, Wroblewska-Czajka E, Kaarniranta K, Aragona P, Wylegala E. 2017. Acta ophthalmologica. 95: 405-413 -
DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells - Implications for age-related macular degeneration (AMD)
Hyttinen JMT, Blasiak J, Niittykoski M, Kinnunen K, Kauppinen A, Salminen A, Kaarniranta K. 2017. Ageing research reviews. 36: 64-77 -
Depletion of the Third Complement Component Ameliorates Age-Dependent Oxidative Stress and Positively Modulates Autophagic Activity in Aged Retinas in a Mouse Model
Roginska Dorota, Kawa Milosz P, Pius-Sadowska Ewa, Lejkowska Renata, Luczkowska Karolina, Wiszniewska Barbara, Kaarniranta Kai, Paterno Jussi J, Schmidt Christian A, Machalinski Boguslaw, Machalinska Anna. 2017. Oxidative medicine and cellular longevity. 2017: 5306790 -
Hypoxia and inflammation in the release of VEGF and interleukins from human retinal pigment epithelial cells
Arjamaa Olli, Aaltonen Vesa, Piippo Niina, Csont Tamás, Petrovski Goran, Kaarniranta Kai, Kauppinen Anu. 2017. Graefes archive for clinical and experimental ophthalmology. 255: 1757-1762 -
Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease
Salminen Antero, Kauppinen Anu, Kaarniranta Kai. 2017. Journal of neurochemistry. 140: 536-549 -
Increased intraocular pressure alters the cellular distribution of HuR protein in retinal ganglion cells : a possible sign of endogenous neuroprotection failure
Smedowski A, Liu X, Podracka L, Akhtar S, Trzeciecka A, Pietrucha-Dutczak M, Lewin-Kowalik J, Urtti A, Ruponen M, Kaarniranta K, Varjosalo M, Amadio M. 2017. Biochimica et biophysica acta: molecular basis of disease. 2018; 1864: 296-306 -
Individual benefits of enoxaparin treatment in branch vein occlusion
Dragoni, Francesco; Kaarniranta, Kai. 2017. Graefes archive for clinical and experimental ophthalmology. 2018; 256: 1031-1033 -
Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity
Salminen A, Kaarniranta K, Kauppinen A. 2017. Cellular signalling. 40: 10-21 -
Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs)
Kinnunen K, Piippo N, Loukovaara S, Hytti M, Kaarniranta K, Kauppinen A. 2017. Journal of cell communication and signaling. 11: 275-279 -
NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy
Loukovaara S, Piippo N, Kinnunen K, Hytti M, Kaarniranta K, Kauppinen A. 2017. Acta ophthalmologica. 95: 803-808 -
Outcome of anti-vascular endothelial growth factor therapy for neovascular age-related macular degeneration in real-life setting
Kataja, M; Hujanen, P; Huhtala, H; Kaarniranta, K; Tuulonen, A; Uusitalo-Jarvinen, H. 2017. British journal of ophthalmology. 2018; 102: 959-965 -
Oxidative Stress, Epigenetics, Environment, and Epidemiology of Diabetic Retinopathy
Petrovski G, Kaarniranta K, Petrovic D. 2017. Journal of Diabetes Research. [Published online 2017 Feb 22]: 1-2 -
Oxidized low-density lipoprotein, lipid and calcium aggregates reveal oxidative stress and inflammation in the conjunctiva of glaucoma patients
Helin-Toiviainen M, Rönkkö S, Kaarniranta K, Puustjärvi T, Rekonen P, Ollikainen M, Uusitalo H. 2017. Acta ophthalmologica. 95: 378-385 -
Predictive factors in endonasal endoscopic lacrimal surgery: a review
Penttilä E, Smirnov G, Kaarniranta K, Seppä J, Tuomilehto H. 2017. B-ent. 13: 129-135 -
Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses
Salminen Antero, Kaarniranta Kai, Kauppinen Anu. 2017. Ageing research reviews. 37: 79-93 -
Silmänpohjan ikärappeuman patogeneesi - autofagian ja inflammasomien vuoropuhelua
Kivinen Niko, Koskela Ali, Kauppinen Anu, Kaarniranta kai. 2017. Duodecim. 133: 641-646 -
The Finnish national guideline for diagnosis, treatment and follow-up of patients with wet age related macular degeneration
Tuuminen Raimo, Uusitalo-Järvinen Hannele, Aaltonen Vesa, Hautala Nina, Kaipiainen Sulevi, Laitamäki Nina, Ollila Marko, Rantanen Jari, Välimäki Satu, Sipilä Raija, Laukkala Tanja, Komulainen Jorma, Tommila Petri, Immonen Ilkka, Tuulonen Anja, Kaarniranta Kai. 2017. Acta ophthalmologica. 95: 1-9 -
The Finnish national guideline for diagnosis, treatment and follow-up of patients with wet age-related macular degeneration
Tuuminen R, Tuulonen A, Kaarniranta K. 2017. Acta ophthalmologica. 95: 649-650 -
The Nobel Prized cellular target autophagy in eye diseases
Kaarniranta Kai, Petrovski Goran, Kauppinen Anu. 2017. Acta ophthalmologica. 95: 335-336 -
Topical cis-urocanic acid prevents ocular surface irritation in both IgE -independent and -mediated rat model
Jauhonen HM, Laihia J, Oksala O, Viiri J, Sironen R, Alajuuma P, Kaarniranta K, Leino L. 2017. Graefes archive for clinical and experimental ophthalmology. 255: 2357-2362 -
Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cell
Hytti M, Szabó D, Piippo N, Korhonen E, Honkakoski P, Kaarniranta K, Petrovski G, Kauppinen A. 2017. Journal of nutritional biochemistry. 42: 37-42 -
Visual processing in patients with age-related macular degeneration performing a face detection test
Vottonen Pasi, Kaarniranta Kai, Pääkkönen Ari, Tarkka Ina M. 2017. Clinical ophthalmology. 11: 1245-1252 -
AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms
Salminen Antero, Kaarniranta Kai, Kauppinen Anu. 2016. Biogerontology. 17: 655-680 -
AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions
Salminen Antero, Kauppinen Anu, Kaarniranta Kai. 2016. Cellular signalling. 28: 887-895 -
Absence of collagen XVIII in mice causes age-related insufficiency in retinal pigment epithelium proteostasis
Kivinen Niko, Felszeghy Szabolcs, Kinnunen Aino I, Setälä Niko, Aikio Mari, Kinnunen Kati, Sironen Reijo, Pihlajaniemi Taina, Kauppinen Anu, Kaarniranta Kai. 2016. Biogerontology. 17: 749-761 -
Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways
Salminen Antero, Kaarniranta Kai, Kauppinen Anu. 2016. Ageing research reviews. 28: 15-26 -
All-Trans Retinoic Acid Modulates DNA Damage Response and the Expression of the VEGF-A and MKI67 Genes in ARPE-19 Cells Subjected to Oxidative Stress
Tokarz Paulina, Piastowska-Ciesielska Agnieszka Wanda, Kaarniranta Kai, Blasiak Janusz. 2016. International journal of molecular sciences. 17: 898 -
Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration
Kaarniranta K, Tokarz P, Koskela A, Paterno J, Blasiak J. 2016. Cell biology and toxicology. 2017; 33: 113-128 -
Benefits of switching from latanoprost to preservative-free tafluprost eye drops: a meta-analysis of two Phase IIIb clinical trials
Uusitalo Hannu, Egorov Evjeniy, Kaarniranta Kai, Astakhov Yuri, Ropo Auli. 2016. Clinical ophthalmology. 10: 445-454 -
Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration
Szatmári-Tóth M, Kristóf E, Veréb Z, Akhtar S, Facskó A, Fésus L, Kauppinen A, Kaarniranta K, Petrovski G. 2016. Cell death and disease. 7: e2367 -
Dry Eye Disease - Nordic Guidelines 2016
Heegaard S, Knudsen LL, van Setten G, Koranyi G, Holopainen J, Kaarniranta K, Klyve P, Raeder S. 2016. . . - -
FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process
Salminen Antero, Kauppinen Anu, Kaarniranta Kai. 2016. Journal of molecular medicine: jmm. 2017; 95: 123-131 -
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Klionsky Daniel J, Abdelmohsen Kotb, Abe Akihisa, Abedin Md Joynal, Abeliovich Hagai, Acevedo Arozena Abraham, Adachi Hiroaki, Adams Christopher M, Adams Peter D, Adeli Khosrow, Adhihetty Peter J, Adler Sharon G, Agam Galila, Agarwal Rajesh, Aghi Manish K, Agnello Maria, Agostinis Patrizia, Aguilar Patricia V, Aguirre-Ghiso Julio, Airoldi Eduardo M et al. 2016. Autophagy. 12: 1-222 -
Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases
Salminen Antero, Kaarniranta Kai, Kauppinen Anu. 2016. Aging and disease. 7: 180-200 -
Inflammation and its role in age-related macular degeneration
Kauppinen Anu, Paterno Jussi J, Blasiak Janusz, Salminen Antero, Kaarniranta Kai. 2016. Cellular and molecular life sciences. 73: 1765-1786 -
Inhibition of BET bromodomains alleviates inflammation in human RPE cells
Hytti Maria, Tokarz P, Määttä E, Piippo Niina, Korhonen Eveliina, Suuronen T, Honkakoski Paavo, Kaarniranta Kai, Lahtela-Kakkonen Maija, Kauppinen Anu. 2016. Biochemical pharmacology. 110-111: 71-79 -
Inhibition of DNA methyltransferase or histone deacetylase protects retinal pigment epithelial cells from DNA damage induced by oxidative stress by the stimulation of antioxidant enzymes
Tokarz Paulina, Kaarniranta Kai, Blasiaka Janusz. 2016. European journal of pharmacology. 776: 167-175 -
Kostea silmänpohjan ikärappeuma (AMD)
Tuuminen R, Uusitalo-Järvinen H, Aaltonen V, Hautala N, Kaipiainen S, Laitamäki N, Ollila M, Rantanen J, Välimäki S, Sipilä R, Laukkala T, Komulainen J, Tommila P, Immonen I, Tuulonen A, Kaarniranta K. Teoksessa: -(toim.) , 2016. Käypä hoito. Suomalaisen Lääkäriseuran Duodecimin ja Suomen Fysiatriyhdistyksen asettama työryhmä. s. -. Duodecim -
Long-term topical application of preservative-free prostaglandin analogues evokes macrophage infiltration in the ocular adnexa
Trzeciecka Anna, Paterno J Jussi, Toropainen Elisa, Koskela Ali, Podracka Lucia, Korhonen Eveliina, Kauppinen Anu, Kaarniranta Kai, Smedowski Adrian. 2016. European journal of pharmacology. 788: 12-20 -
Lääketieteen Nobelin palkinto autofagian tutkijalle
Kaarniranta Kai, Meri Seppo, Eskelinen Eeva-Liisa. 2016. Duodecim. 132: 2141-2144 -
Melatonin in retinal physiology and pathology: the case of age-related macular degeneration
Blasiak J, Reiter RJ, Kaarniranta K. 2016. Oxidative medicine and cellular longevity. 2016: 6819736, 12 pages -
Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells
Koskela Ali, Reinisalo Mika, Petrovski Goran, Sinha Debasish, Olmiere Céline, Karjalainen Reijo, Kaarniranta Kai. 2016. Nutrients. 8: 284 -
Nya behandlingar vid synhotande makulasjukdomer
Paterno J, Ikäheimo K, Kinnunen K, Kaarniranta K. 2016. Finska läkaresällskapets handlingar. 176: 10-14 -
2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process
Salminen Antero, Kauppinen Anu, Kaarniranta Kai. 2015. Cellular and molecular life sciences. 72: 3897-3914 -
A novel proteotoxic stress associated mechanism for macular corneal dystrophy
Kaarniranta Kai, Szalai Eszter, Smedowski Adrian, Hegyi Zoltán, Kivinen Niko, Viiri Johanna, Wowra Bogumil, Dobrowolski Dariusz, Módis Jr. László, Berta András, Wylegala Edward, Felszeghy Szabolcs. 2015. Histology and histopathology. 30: 921-930 -
A randomized phase I clinical study of cis-urocanic acid eye drops in healthy adult subjects
Jauhonen Hanna-Mari, Kari Eeva, Pylkkänen Liisa, Poutanen Jutta, Laihia Jarmo, Kaarniranta Kai, Leino Lasse. 2015. Acta ophthalmologica. 93: 368-376 -
Ageing of the vitreous: From acute onset floaters and flashes to retinal detachment
Lumi Xhevat, Hawlina Marko, Glavac Damjan, Facsko Andrea, Moe Morten C, Kaarniranta Kai, Petrovski Goran. 2015. Ageing research reviews. 21: 71-77 -
Autophagy in DNA Damage Response
Czarny Piotr, Pawlowska Elzbieta, Bialkowska-Warzecha Jolanta, Kaarniranta Kai, Blasiak Janusz. 2015. International journal of molecular sciences. 16: 2641-2662 -
Best-corrected visual acuity and retinal thickness are associated with improved cortical visual processing in treated wet AMD patients
Vottonen Pasi, Pääkkönen Ari, Tarkka Ina M, Kaarniranta Kai. 2015. Acta ophthalmologica. 93: 621-25 -
Climatic droplet keratopathy: an old disease in new clothes
Serra Horacio M, Holopainen Juha M, Beuerman Roger, Kaarniranta Kai, Suarez Maria F, Urrets-Zavalia Julio A. 2015. Acta ophthalmologica. 93: 496-504 -
Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration
Ferrington Deborah A, Sinha Debasish, Kaarniranta Kai. 2015. Progress in retinal and eye research. 2016; 51: 69-89 -
Diabeettisen retinopatian uudet hoidot ja diagnostiikka
Karttunen Tommi, Kaarniranta Kai, Kinnunen Kati. 2015. DIABETES JA LÄÄKÄRI. 44: 17-22 -
Endoscopic dacryocystorhinostomy as treatment for lower lacrimal pathway obstructions in adults : Review article
Penttilä Elina, Smirnov Grigori, Tuomilehto Henri, Kaarniranta Kai, Seppä Juha. 2015. Allergy and rhinology. 6: e12-e19 -
Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation
Hytti Maria, Piippo Niina, Korhonen Eveliina, Honkakoski Paavo, Kaarniranta Kai, Kauppinen Anu. 2015. Scientific reports. 5: -
Health-related quality of life after caract surgery with the phacoemulsification technique and intraocular lens implantation
Porela-Tiihonen Susanna, Roine Risto P, Sintonen Harri, Kaarniranta Kai, Kokki Merja, Kokki Hannu. 2015. Acta ophthalmologica. 2016; 94: 21-25 -
Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape
Salminen Antero, Haapasalo Annakaisa, Kauppinen Anu, Kaarniranta Kai, Soininen Hilkka, Hiltunen Mikko. 2015. Progress in neurobiology. epub ahead of print 19 May 2015: -
Lysosomes: Regulators of autophagy in the retinal pigmented epithelium
Sinha Debasish, Valapala Mallika, Shang Peng, Hose Stacey, Grebe Rhonda, Lutty Gerard A, Zigler Jr J Samuel, Kaarniranta Kai, Handa James T. 2015. Experimental eye research. 144 (2016): 46-53 -
Pharmacokinetics, Efficacy, and Safety of the Preservative-free Fixed Combination of Tafluprost 0.0015 % and Timolol 0.5 % in Healthy Volunteers: A Phase I Comparison vs. the Corresponding Preservative-free Monotherapies
Kaarniranta Kai, Ikäheimo Kirsi, Mannermaa Eliisa, Ropo Auli. 2015. Clinical pharmacokinetics. [epub ahead of print 21 Sep 2015]: 1-10 -
Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases
Reinisalo Mika, Kårlund Anna, Koskela Ali, Kaaniranta Kai, Karjalainen Reijo O.. 2015. Oxidative medicine and cellular longevity. 2015, Article ID 340520: 24 p. -
Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells
Hytti Maria, Piippo Niina, Salminen Antero, Honkakoski Paavo, Kaarniranta Kai, Kauppinen Anu. 2015. Experimental eye research. 132: 208-215 -
Role of the cell cycle re-initiation in DNA damage response of post-mitotic cells and its implication in the pathogenesis of neurodegenerative diseases
Tokarz Paulina, Kaarniranta Kai, Blasiak Janusz. 2015. Rejuvenation research. 19: 1-9 -
The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells
Johansson Ida, Monsen Vivi Talstad, Pettersen Kristine, Mildenberger Jennifer, Misund Kristine, Kaarniranta Kai, Schønberg Svanhild, Bjørkøy Geir. 2015. Autophagy. 11: 1636-1651 -
A 6-month study comparing efficacy, safety, and tolerability of the preservative-free fixed combination of tafluprost 0.0015% and timolol 0.5% versus each of its individual preservative-free components
Pfeiffer N, Traverso CE, Lorenz K, Saarela V, Liinamaa J, Uusitalo H, Astakhov Y, Boiko E, Ropo A, Preservative-free Tafluprost/Timolol Fixed Combination Study Group Collaborators: Uusitalo H, Kaarniranta K,Saarela V, Pfeiffer N, Bartz-Schmidt U, Dunker S, Hamacher T, Heidemann K,Hofmann G, et al.. 2014. Advances in therapy. 31: 1228-1246 -
A rat experimental model of glaucoma incorporating rapid-onset elevation of intraocular pressure
Smedowski A, Pietrucha-Dutczak M, Kaarniranta K, Lewin-Kowalik J. 2014. Scientific reports. 4: 5910; 1-11 -
ADAMTS9 locus associates with increased risk of wet AMD
Helisalmi Seppo, Immonen Ilkka, Losonczy Gergely, Resch Miklos D, Benedek Szabolcs, Balogh Istvan, Papp Andras, Berta Andras, Uusitupa Matti, Hiltunen Mikko, Kaarniranta Kai. 2014. Acta ophthalmologica. 2014: 1 -
Bevacizumab does not affect autophagy clearance during proteasomal inhibition in human retinal pigment epithelial cells
Kivinen Niko, Dithmer Michaela, Kinnunen Kati, Lucius Ralph, Roider Johann, Kaarniranta Kai, Klettner Alexa. 2014. Journal of biochemical and pharmacological research. 2: 44-53 -
CB2 receptor as a potential target in age-related diseases
Kauppinen Anu, Nevalainen Tapio, Hytti Maria, Salminen Antero, Kaarniranta Kai, Parkkari Teija. 2014. Journal of biochemical and pharmacological research. 2: 33-43 -
Cationorm shows good tolerability on human HCE-2 corneal epithelial cell cultures
Kinnunen Kati, Kauppinen Anu, Piippo Niina, Koistinen Arto, Toropainen Elisa, Kaarniranta Kai. 2014. Experimental eye research. 120: 82-89 -
Clearance of misfolded and aggregated proteins by aggrephagy and implications for aggregation diseases
Hyttinen JM, Amadio M, Viiri J, Pascale A, Salminen A, Kaarniranta K. 2014. Ageing research reviews. 18: 16-28 -
Comparison of three intraocular pressure measurement methods including biomechanical properties of the cornea
Smedowski Adrian, Weglarz Beata, Tarnawska Dorota, Kaarniranta Kai, Wylegala Edward. 2014. Investigative ophthalmology and visual science. 55: 666-673 -
Decline in cellular clearance systems induces inflammasome signaling in human ARPE-19 cells
Piippo N, Korkmaz A, Hytti M, Kinnunen K, Salminen A, Atalay M, Kaarniranta K, Kauppinen A. 2014. Biochimica et biophysica acta: molecular cell research. 1843: 3038-3046 -
Estrogen Signalling in the Pathogenesis of Age-Related Macular Degeneration
Kaarniranta Kai, Machalinska Anna, Veréb Zoltán, Salminen Antero, Petrovski Goran, Kauppinen Anu. 2014. Current eye research. 2014: 1-8 -
Excipients of preservative-free latanoprost induced inflammatory response and cytotoxicity in immortalized human HCE-2 corneal epithelial cells
Smedowski Adrian, Paterno Jussi J, Toropainen Elisa,Sinha Debasish, Wylegala Edward, Kaarniranta Kai. 2014. Journal of biochemical and pharmacological research. 2: 175-184 -
Herpes simplex virus types 1 and 2 modulate autophagy in SIRC corneal cells
Petrovski G, Pásztor K, Orosz L, Albert R, Mencel E, Moe MC, Kaarniranta K, Facskó A, Megyeri K. 2014. Journal of biosciences. 39: 683-692 -
Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process
Salminen Antero, Kaarniranta Kai, Hiltunen Mikko, Kauppinen Anu. 2014. Journal of molecular medicine: jmm. -: - -
Hsp70 binds reversibly to proteasome inhibitor-induced protein aggregates and evades autophagic clearance in ARPE-19 cells
Kivinen Niko, Hyttinen Juha MT, Viiri Johanna, Paterno Jussi, Felszheghy Szabolcs, Kauppinen Anu, Salminen Antero, Kaarniranta Kai. 2014. Journal of biochemical and pharmacological research. 2: 1-7 -
Hypoxic conditions stimulate the release of B-type natriuretic peptide from human retinal pigment epithelium cell culture
Aaltonen Vesa, Kinnunen Kati, Jouhilahti Eeva-Mari, Peltonen Juha, Nikinmaa Mikko, Kaarniranta Kai, Arjamaa Olli. 2014. Acta ophthalmologica. 92: 740-744 -
Inflammaging Signaling in Health Span and Life Span Regulation: Next Generation Targets for Longevity
Salminen A, Kauppinen A, Kaarniranta K. Teoksessa: Irfan Rahman and Debasis Bagchi(toim.) , 2014. Inflammation, Advancing Age and Nutrition: Research and Clinical Interventions. s. 323-332. Academic press -
Krebs cycle dysfunction shapes epigenetic landscape of chromatin: Novel insights into mitochondrial regulation of aging process
Salminen Antero, Kaarniranta Kai, Hiltunen Mikko, Kauppinen Anu. 2014. Cellular signalling. 26: 1598-1603 -
Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process
Salminen Antero, Kauppinen Anu, Hiltunen Mikko, Kaarniranta Kai. 2014. Ageing research reviews. 16: 45-65 -
Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress
Oksala Niku KJ, Ekmekci F Güler, Özsoy Ergi, Kirankaya Serife, Kokkola Tarja, Emecen Güzin, Lappalainen Jani, Kaarniranta Kai, Atalay Mustafa. 2014. Redox biology. 3: 25-28 -
Oxidative Stress Protection by Exogenous Delivery of rhHsp70 Chaperone to the Retinal Pigment Epithelium (RPE), a Possible Therapeutic Strategy Against RPE Degeneration
Subrizi Astrid, Toropainen Elisa, Ramsay Eva, Airaksinen Anu J, Kaarniranta Kai, Urtti Arto. 2014. Pharmaceutical research. 2015; 32: 211-221 -
Oxidative stress plays an important role in zoledronic acid-induced autophagy
Khandelwal VK, Mitrofan LM, Hyttinen JM, Chaudhari KR, Buccione R, Kaarniranta K, Ravingerová T, Mönkkönen J. 2014. Physiological research. 63: S601-S612 -
Oxidative stress, hypoxia, and autophagy in the neovascular processes of age-related macular degeneration
Blasiak Janusz, Petrovski Goran, Veréb Zoltan, Facskó Andrea, Kaarniranta Kai. 2014. Journal of biomedicine and biotechnology. 2014: 1-7 -
Pinosylvin-mediated protection against oxidative stress in human retinal pigment epithelial cells
Koskela Ali, Reinisalo Mika, Hyttinen Juha MT, Kaarniranta Kai, Karjalainen Reijo O. 2014. Molecular vision. 20: 760-769 -
Recovery and patient satisfaction after cataract surgery. A one-year prospective follow-up study
Porela-Tiihonen S, Kaarniranta K, Kokki M, Kokki H. 2014. Acta ophthalmologica. 93: e172-e173 -
Silmänpohjan kostea ikärappeuma pitää hoitaa ajoissa
Kinnunen K, Kaarniranta K. 2014. Lääkärilehti. 69: 2265-2268 -
Structure and barrier properties of human embryonic stem cell-derived retinal pigment epithelial cells are affected by extracellular matrix protein coating
Sorkio Anni, Hongisto Heidi, Kaarniranta Kai, Uusitalo Hannu, Juuti-Uusitalo Kati, Skottman Heli. 2014. Tissue engineering. 20: 622-634 -
Upregulation of inflammatory genes in the nasal mucosa of patients undergoing endonasal dacryocystorhinostomy
Penttilä E, Hyttinen JMT, Hytti M, Kauppinen A, Smirnov G, Tuomilehto H, Seppä J, Nuutinen J, Kaarniranta K. 2014. Clinical ophthalmology. 8: 799-805 -
A prospective study on postoperative pain after cataract surgery.
Porela-Tiihonen S, Kaarniranta K, Kokki M, Purhonen S, Kokki H. 2013. Clinical ophthalmology. 7: 1429-1435 -
Antagonistic crosstalk between NF-kappaB and SIRT1 in the regulation of inflammation and metabolic disorders
Kauppinen A, Suuronen T, Ojala J, Kaarniranta K, Salminen A. 2013. Cellular signalling. 25: 1939-1948 -
Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells
Viiri J, Amadio M, Marchesi N, Hyttinen JM, Kivinen N, Sironen R, Rilla K, Akhtar S, Provenzani A, D'Agostino VG, Govoni S, Pascale A, Agostini H, Petrovski G, Salminen A, Kaarniranta K. 2013. PLoS ONE. 8: e6963, 16 pages -
Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration
Kaarniranta K, Sinha D, Blasiak J, Kauppinen A, Vereb Z, Salminen A, Boulton ME, Petrovski G. 2013. Autophagy. 9: 1-12 -
Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process
Salminen A, Kaarniranta K, Kauppinen A. 2013. Ageing research reviews. 12: 520-534 -
Cellular and molecular mechanisms of age-related macular degeneration: From impaired autophagy to neovascularization
Klettner A, Kauppinen A, Blasiak J, Roider J, Salminen A, Kaarniranta K. 2013. International journal of biochemistry and cell biology. 45: 1457-1467 -
Changes in neurophysiologic markers of visual processing following beneficial anti-VEGF treatment in macular degeneration
Vottonen P, Kaarniranta K, Pääkkönen A, Tarkka IM. 2013. Clinical ophthalmology. 7: 437-442 -
Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process
Salminen A, Kaarniranta K, Kauppinen A. 2013. International journal of molecular sciences. 14: 3834-3859 -
Epigenetic regulation of ASC/TMS1 expression: potential role in apoptosis and inflammasome function
Salminen A, Kauppinen A, Hiltunen M, Kaarniranta K. 2013. Cellular and molecular life sciences. -: - -
Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome
Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. 2013. Progress in neurobiology. 106-107: 33-54 -
Inflammation as a target of minocycline: special interest in the regulation of inflammasome signaling
Kauppinen A, Salminen A, Kaarniranta K. 2013. Inflammasome. 1: 2-14 -
Maturation of autophagosomes and endosomes: A key role for Rab7
Hyttinen JMT, Niittykoski M, Salminen A, Kaarniranta K. 2013. Biochimica et biophysica acta: international journal of biochemistry and biophysics. 1833: 503-510 -
Mitochondrial and nuclear DNA damage and repair in age-related macular degeneration
Blasiak J, Glowacki S, Kauppinen A, Kaarniranta K. 2013. International journal of molecular sciences. 14: 2996-3010 -
Oxidative DNA Damage and Proteostasis in Age-Related Macular Degeneration
Tokarz P, Kauppinen A, Kaarniranta K, Blasiak J. 2013. Journal of biochemical and pharmacological research. 1: 106-113 -
Postoperative pain after cataract surgery
Porela-Tiihonen S, Kaarniranta K, Kokki H. 2013. Journal of cataract and refractive surgery. 39: 789-98 -
Potential of epigenetic mechanisms in AMD pathology
Blasiak J, Salminen A, Kaarniranta K. 2013. FRONTIERS IN BIOSCIENCE. 5: 412-425 -
Retinal arterial macroaneurysms
Pitkänen L, Tommila P, Kaarniranta K, Jääskeläinen JE, Kinnunen K. 2013. Acta ophthalmologica. 2013: 1-4 -
Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD)
Tokarz P, Kaarniranta K, Blasiak J. 2013. Biogerontology. 14: 461-82 -
Silmänpohjan kostean ikärappeuman hoito
Kaarniranta K. 2013. Terveydenhoitoviesti. 1: 20 -
AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
Salminen A, Kaarniranta K. 2012. Ageing research reviews. 11: 230-241 -
Adiponectin receptor 1 gene (ADIPOR1) variant is associated with advanced age-related macular degeneration in Finnish population
Kaarniranta K, Paananen J, Nevalainen T, Sorri I, Seitsonen S, Immonen I, Salminen A, Pulkkinen L, Uusitupa M. 2012. Neuroscience letters. 513: 233-237 -
Aikuisten alakyyneltietukosten kirurginen hoito
Seppä J, Smirnov G, Kaarniranta K, Tuomilehto H. 2012. Duodecim. 128: 205-2011 -
Autophagy in the eye: a double-edged sword, (Chapter 8)
Petrovski, G; Albert, R; Kaarniranta, K; Morten, CM; Fésus, L; Berta, A; Das, DK. Teoksessa: Ed. Gorbunov, Nikolai(toim.) , 2012. Autophagy: Principles, Regulation & Roles in Disease.. s. 157-180. Nova science publishers -
Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration
Kaarniranta K, Kauppinen A, Blasiak J, Salminen A. 2012. Future medicinal chemistry. 4: 2153-2161 -
Bilberries potentially alleviate stress-related retinal gene expression induced by a high-fat diet in mice
Mykkänen OT, Kalesnykas G, Adriaens M, Evelo CT, Törrönen R, Kaarniranta K. 2012. Molecular vision. 18: 2338-2351 -
Context-dependent regulation of autophagy by IKK-NF-kappaB signaling: Impact on the aging process
Salminen A, Hyttinen JMT, Kauppinen A, Kaarniranta K. 2012. International journal of cell biology. 2012: 15 pages -
Efflux Protein Expression in Human Stem Cell-Derived Retinal Pigment Epithelial Cells
Juuti-Uusitalo, K; Vaajasaari, H; Ryhänen, T; Narkilahti, S; Suuronen, R; Mannermaa, E; Kaarniranta, K; Skottman, H. 2012. PLoS ONE. 7: 1-10 -
Emerging role of NF-kappaB signaling in the induction of senescence-associated secretory phenotype (SASP)
Salminen A, Kauppinen A, Kaarniranta K. 2012. Cellular signalling. 24: 835-845 -
Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease
Salminen, A; Kaarniranta, K; Haapasalo, A; Hiltunen, M; Soininen, H; Alafuzoff, I. 2012. Progress in neurobiology. 96: 87-95 -
Fibrillin-2, tenascin-C, matrilin-2, and matrilin-4 are strongly expressed in the epithelium of human granular and lattice type I corneal dystrophies
Szalai, E; Felszeghy, S; Hegyi, Z; Módis, L Jr; Berta, A; Kaarniranta, K. 2012. Molecular vision. 18: 1927-1936 -
Genetic Variability in DNA Repair Proteins in Age-Related Macular Degeneration
Blasiak, J; Synowiec, E; Salminen, A; Kaarniranta, K. 2012. International journal of molecular sciences. 13: 13378-13379 -
Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, DJ, Abdalla, FC; Abeliovich, H; Abraham, RT; Acevedo-Arozena, A; Adeli, K; Agholme, L; Agnello, M; Agostinis, P; Aguirre-Ghiso, JA; Ait-Mohamed, O; Ait-Si-Ali, S; Akematsu, T; Akira, S; Al-Younes, HM; Al-Zeer, MA; Albert, ML; Albin, RL; Alegre-Abarrategui, J; Kaarniranta, K; et al.. 2012. Autophagy. 8: 445-544 -
Inflammaging: disturbed interplay between autophagy and inflammasomes
Salminen, A; Kaarniranta, K; Kauppinen, A. 2012. Aging. 4: 166-175 -
Mitochondrial dysfunction and oxidative stress active inflammasomes: impact on the aging process and age-related diseases
Salminen A, Ojala J, Kaarniranta K, Kauppinen A. 2012. Cellular and molecular life sciences. 69: 2999-3013 -
Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration
Kinnunen, K; Petrovski, G; Moe, MC; Berta, A; Kaarniranta, K. 2012. Acta ophthalmologica. 90: 299-309 -
Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells - Implications for age-related macular degeneration (AMD)
Kauppinen A, Niskanen H, Suuronen T, Kinnunen K, Salminen A, Kaarniranta K. 2012. Immunology letters. 147: 29-33 -
Phytochemicals suppress nuclear factor-kappaB signaling: impact on health span and the aging process
Salminen A, Kauppinen A, Kaarniranta K. 2012. Current opinion in clinical nutrition and metabolic care. 15: 23-28 -
Protective function of wood-derived stilbenes against oxidative stress and inflammation in ARPE-19 cells
Mika Reinisalo, Tuomas Paimela, Tuomas Ryhänen, Anu Kauppinen, Ali Koskela, Tuula Soininen, Kai Kaarniranta, Reijo Karjalainen. 2012. -
Protein-oxidized phospholipid interactions in cellular signaling for cell death: From biophysics to clinical correlations
Kinnunen, PK; Kaarniranta, K; Mahalka, AK. 2012. Biochimica et biophysica acta: biomembranes. 1818: 2446-2455 -
Relation of biometric eye profile with intraocular pressure corrections in healthy myopes
Pärssinen, O; Hiltunen, H; Kaarniranta, K. 2012. Acta ophthalmologica. 90: e410-412 -
Silmänpohjan ikärappeuma yleistyy
Kaarniranta, K. 2012. OPTOMETRIA. 3: 39-41 -
The preservative polyquaternium-1 increases cytoxicity and NF-kappaB linked inflammation in human corneal epithelial cells
Paimela, T; Ryhänen, T; Kauppinen, A; Marttila, L; Salminen, A; Kaarniranta, K. 2012. Molecular vision. 18: 1189-1196 -
5'-adenosine monophosphate-activated protein kinase-Mammalian target of rapamycin axis as therapeutic target for age-related macular degeneration
Hyttinen JM, Petrovski G, Salminen A, Kaarniranta K. 2011. Rejuvenation research. 14: 651-660 -
AMP-activated protein kinase inhibits NF-kappaB signaling and inflammation: impact on healthspan and lifespan
Salminen A, Hyttinen JMT, Kaarniranta K. 2011. Journal of molecular medicine: jmm. 89: 667-676 -
AMP-activated protein kinase: a potential player in Alzheimer's disease
Salminen A, Kaarniranta K, Haapasalo A, Soininen H, Hiltunen M. 2011. Journal of neurochemistry. 118: 460-474 -
Age-related macular degeneration (AMD): Alzheimer's Disease in the eye
Kaarniranta K, Salminen A, Haapasalo A, Soininen H, Hiltunen M. 2011. Journal of Alzheimer's disease. 24: 615-631 -
Apoptosis and aging: increased resistance to apoptosis enhances the aging process
Salminen A, Ojala J, Kaarniranta K. 2011. Cellular and molecular life sciences. 68: 1021-1031 -
Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype
Salminen A, Ojala J, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H. 2011. European journal of neuroscience. 34: 3-11 -
Biocompatibility of different poly(lactide-coglycolide) polymers implanted into the subconjunctival space in rats
Seppo Rönkkö, Kai Kaarniranta, Giedrius Kalesnykas, Hannu Uusitalo. 2011. Ophthalmic research. 46: 55-65 -
Celastrol regulates innate immunity response via NF-kappaB and Hsp70 in human retinal pigment epithelial cells
Paimela T, Hyttinen JMT, Viiri J, Ryhänen T, Karjalainen RO, Salminen A, Kaarniranta K. 2011. Pharmacological research. 64: 501-508 -
Cis-urocanic acid inhibits SAPK/JNK signaling pathway in UV-B exposed human corneal epithelial cells in vitro
Jauhonen H-M, Kauppinen A, Paimela T, Laihia JK, Leino L, Salminen A, Kaarniranta K. 2011. Molecular vision. 17: 2311-2317 -
Control of p53 and NF-kB signaling by WIP1 and MIF: Role in cellular senescence and organismal aging
Salminen Antero, Kaarniranta Kai. 2011. Cellular signalling. 23: 747-752 -
Emerging role of p62/sequestosome-1 in th pathogenesis of Alzheimer's disease
Salminen A, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H, Alafuzoff I. 2011. Progress in neurobiology. 96: 87-95 -
Increased IL-6 levels are not related to NF-kappaB or HIF-1alfa: transcription factors activity in the vitreous of proliferative diabetic retinopathy
Arjamaa O, Pöllönen M, Kinnunen K, Ryhänen T, Kaarniranta K. 2011. Journal of diabetes and its complications. 25: 393-397 -
Mitomycin C in revision endoscopic dacryocystorhinostomy: A prospective randomized study
Penttilä E, Smirnov G, Seppä J, Kaarniranta K, Tuomilehto H. 2011. American journal of rhinology and allergy. 25: 425-428 -
Plant flavonol quercetin and isoflavone biochanin-A differentially induce protection against oxidative stress and inflammation in ARPE-cells
Saviranta Niina, Veeroos Laura, Granlund Lars, Hassinen Viivi, Kaarniranta Kai, Karjalainen Reijo. 2011. Food research international. 44: 109-113 -
Ravistellun lapsen oireyhtymään liittyvät silmälöydökset
Nevalainen T, Kaarniranta K, Puustjärvi T, Kontkanen M. 2011. Lääkärilehti. 66: 453-455 -
Silmänpohjan ikärappeuman hoidossa halvempi on tehokas ja turvallinen
Kaarniranta K. 2011. Lääkärilehti. 22: 1812 -
Strong expression of HSP47 in metaplastic nasal mucosa may predict a poor outcome after primary endoscopic dacryocystorhinostomy: a prospective study
Smirnov G, Pirinen R, Tuomilehto H, Seppä J, Teräsvirta M, Uusitalo H, Nuutinen J, Kaarniranta K. 2011. Acta ophthalmologica. 89: e132-e136 -
Altered calcium signaling in a experimental model of glaucoma
Niittykoski M, Kalesnykas G, Larsson KP, Kaarniranta K, Åkerman KEO, Uusitalo H. 2010. Investigative ophthalmology and visual science. 51: 6387-6393 -
Autophagy - hot topic in AMD
Kaarniranta K. 2010. Acta ophthalmologica. 88: 387-388 -
Celastrol: Molecular targets of Thunder God Vine
Salminen A, Lehtonen M, Paimela T & Kaarniranta K. 2010. Biochemical and biophysical research communications. 394: 439 - 442 -
ER stress and hormetic regulation of the aging process
Salminen A & Kaarniranta K. 2010. Ageing research reviews. 9: 211-217 -
Endoplasmic reticulum stress in age-related macular degeneration: Trigger for neovascularization
Salminen A, Kauppinen A, Hyttinen JMT, Toropainen E & Kaarniranta K. 2010. MOLECULAR MEDICINE TODAY. 16: 535-542 -
Filter-cultured ARPE-19 cells as outer blood-retinal barrier model
Mannermaa E, Reinisalo M, Ranta V-P, Vellonen K-S, Kokki H, Saarikko A, Kaarniranta K & Urtti A. 2010. European journal of pharmaceutical sciences. 40: 289-296 -
Genetics vs. entrophy: Longevity factors suppress the NF-kB-driven entropic aging process
Salminen A & Kaarniranta K. 2010. Ageing research reviews. 9: 298-314 -
Glycolysis Links p53 Function With NF-kB Signaling: Impact on Cancer and Aging Process
Salminen A & Kaarniranta K. 2010. Journal of cellular physiology. 224: 1-6 -
Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease
Salminen A, Ojala J, Kaarniranta K, Hiltunen M & Soininen H. 2010. Progress in neurobiology. 93: 99-110 -
Influence of Hsp90 and HDAC Inhibition and Tubulin Acetylation on Perinuclear Protein Aggregation in Human Retinal Pigment Epithelial Cells
Ryhänen T, Viiri J, Hyttinen JTM, Uusitalo H, Salminen A & Kaarniranta K. 2010. Journal of biomedicine and biotechnology. 2011;2011;798052. Epub 2010 Oct 24: 1-8 -
Influence of selective estrogen receptor modulators on interleukin-6 expression in human retinal pigment epithelial cells (ARPE-19)
Paimela T, Hyttinen JMT, Viiri J, Ryhänen T, Karvonen MK, Unkila M, Uusitalo H, Salminen A & Kaarniranta K. 2010. European journal of pharmacology. 640: 219-225 -
Insulin/IGF-1 paradox of aging: Regulation via AKT/IKK/NF-kB signaling
Salminen A & Kaarniranta K. 2010. Cellular signalling. 22: 573-577 -
Mechanisms of protein aggregation in the retinal pigment epithelial cells
Kai Kaarniranta, Juha Hyttinen, Tuomas Ryhanen, Johanna Viiri, Tuomas Paimela, Elisa Toropainen, Iiris Sorri & Antero Salminen. 2010. FRONTIERS IN BIOSCIENCE. E2: 1374-1384 -
Regression of necrotizing scleritis in Wegener's granulomatosis after infiximab treatment
Kaarniranta K. 2010. Acta ophthalmologica. 88: e96-97 -
Switching from a preserved toa preservative-free prostaglandin preparation in topical glaucoma medication
Uusitalo H, Chen E, Pfeiffer N, Brignole-Baudouin F, Kaarniranta K, Leino M, Puska P, Palmgren E, Hamacher T, Hofmann G, Petzold G, Richter U, Riedel T, Winter M & Ropo A. 2010. Acta ophthalmologica. 88: 329-336 -
Symptom score questionnaire for nasolacrimal duct obstruction in adults - a novel tool to assess the outcome after endoscopic dacryocystorhinostomy
Smirnov G, Tuomilehto H, Kokki H, Kemppainen T, Kiviniemi V, Nuutinen J, Kaarniranta K & Seppä J. 2010. Rhinology. 48: 446-451 -
p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells
Viiri J, Hyttinen JMT, Ryhänen T, Rilla K, Paimela T, Kuusisto E, Siitonen A, Urtti A, Salminen A & Kaarniranta K. 2010. Molecular vision. 16: 1399-1414 -
Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors
Kaarniranta K, Salminen A. 2009. Journal of molecular medicine: jmm. 87: 117-123 -
Cis-urocanic acid suppresses UV-B-induced interleukin-6 and -8 secretion and cytotoxicity in human corneal and conjunctival epithelial cells in vitro
Viiri J, Jauhonen HM, Kauppinen A, Ryhänen T, Paimela T, Hyttinen J, Sorri I, Laihia JK, Leino L, Kaarniranta K. 2009. Molecular vision. 15: 1799-1805 -
ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology
Salminen A, Kauppinen A, Suuronen T, Kaarniranta K, Ojala J. 2009. Journal of neuroinflammation. 6: [13 p.] -
Efflux protein expression in human retinal pigment epithelium cell lines
Mannermaa E, Vellonen K-S, Ryhänen T, Kokkonen K, Ranta V-P, Kaarniranta K, Urtti A. 2009. Pharmaceutical research. 26: 1785-1791 -
Heat shock proteins as gatekeepers of proteolytic pathways - Implications for age-related macular generation (AMD)
Kaarniranta K, Salminen A, Eskelinen E-L, Kopitz J. 2009. Ageing research reviews. 8: 128-139 -
Inflammation in Alzheimer's disease: Amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors
Salminen A, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. 2009. Progress in neurobiology. 87: 181-194 -
NF-kappaB signaling as a putative target for omega-3 metabolites in the prevention of age-related macular degeneration (AMD)
Kaarniranta K, Salminen A. 2009. Experimental gerontology. 44: 685-688 -
NF-kappaB signaling in the aging process
Salminen A, Kaarniranta K. 2009. Journal of clinical immunology. 29: 397-405 -
Regulation of the aging process by autophagy
Salminen A, Kaarniranta K. 2009. Trends in molecular medicine. 15: 217-224 -
Regulatory role of HIF-1alfa in the pathogenesis of age-related macular degeneration (AMD)
Arjamaa O, Nikinmaa M, Salminen A, Kaarniranta K. 2009. Ageing research reviews. 8: 349-358 -
Retinal haemorrhages in shaken baby syndrome
Kontkanen M, Kaarniranta K. 2009. Acta ophthalmologica -
SIRT1 regulates the ribosomal DNA locus: Epigenetic candles twinkle longevity in the Christmas tree
Salminen A, Kaarniranta K. 2009. Biochemical and biophysical research communications. 378: 6-9 -
SIRT1: Regulation of longevity via autophagy
Salminen A, Kaarniranta K. 2009. Cellular signalling. 21: 1356-1360 -
Siglec receptors and hiding plaques in Alzheimer's disease
Salminen A, Kaarniranta K. 2009. Journal of molecular medicine: jmm. 87: 697-701 -
Silmänpohjan ikärappeuman patogeneesi
Kaarniranta K, Seitsonen S, Paimela T, Meri S, Immonen I. 2009. Duodecim. 125: 145-153 -
Silmänpohjan ikärappeuman riskitekijät ja hoito
Kaarniranta K, Puustjärvi T, Sorri I. 2009. TERVEYDENHOITOVIESTI, KESKI-SUOMI PIRKANMAA. : s. 16, 29 -
Single nucleotide polymorphisms of the tenomodulin gene (TNMD) in age-related macular degeneration
Tolppanen A-M, Nevalainen T, Kolehmainen M, Seitsonen S, Immonen I, Uusitupa M, Kaarniranta K, Pulkkinen L, Tolppanen A-M, Kolehmainen M, Uusitupa M, Pulkkinen L. 2009. Molecular vision. 15: 762-770 -
Vääristyvä kuva silmänpohjan ikärappeumassa - kuinka hoidetaan?
Kaarniranta K. 2009. Lääkärilehti. 64: 3759-3763 -
Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging
Salminen A, Huuskonen J, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. 2008. Ageing research reviews. 7: 83-105 -
Amyloid-beta oligomers set fire to inflammasomes and induce Alzherimer's pathology
Salminen A, Ojala J, Suuronen T, Kaarniranta K, Kauppinen A. 2008. Journal of cellular and molecular medicine. 12: 2255-2262 -
Diabeteksen aiheuttamat silmämuutokset
Kaarniranta K, Sorri I. 2008. Lääkärilehti. 63: 621-624 -
Histopathology of the three implanted degradable biopolymers in rabbit eye
Rönkkö S, Rekonen P, Sihvola R, Kaarniranta K, Puustjärvi T, Teräsvirta M, Uusitalo H. 2008. Journal of biomedical materials research part a. 88: 717-724 -
In vitro biocompatibility of degradable biopolymers in cell line cultures from various ocular tissues: extraction studies
Huhtala A, Pohjonen T, Salminen L, Salminen A, Kaarniranta K, Uusitalo H. 2008. Journal of materials science: materials in medicine. 19: 645-649 -
Innate immunity meets with cellular stress at the IKK complex: Regulation of the IKK complex by HSP70 and HSP90
Salminen A, Paimela T, Suuronen T, Kaarniranta K. 2008. Immunology letters. 117: 9-15 -
Interaction of aging-associated signaling cascades: Inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1
Salminen A, Ojala J, Huuskonen J, Kauppinen A, Suuronen T, Kaarniranta K. 2008. Cellular and molecular life sciences. 65: 1049-1058 -
Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration
Seitsonen SP, Onkamo P, Peng G, Xiong M, Tommila PV, Ranta PH, Holopainen JM, Moilanen JA, Palosaari T, Kaarniranta K, Meri S, Immonen IR, Järvelä IE. 2008. PLoS ONE. 3: e3833 -
NEMO shuttle: a link between DNA damage and NF-kappaB activation in progeroid syndromes?
Salminen A, Suuronen T, Huuskonen J, Kaarniranta K. 2008. Biochemical and biophysical research communications. 367: 715-718 -
Pharmacokinetics, efficacy and safety profiles of preserved and preservative-free tafluprost in healthy volunteers
Uusitalo H, Kaarniranta K, Ropo A. 2008. Acta ophthalmologica. Supplement. 86: 7-13 -
ROCK, PAK, and Toll of synapses in Alzheimer's disease
Salminen A, Suuronen T, Kaarniranta K. 2008. Biochemical and biophysical research communications. 371: 587-590 -
Radicicol but not geldanamycin evokes oxidative stress response and efflux protein inhibition in ARPE-19 human retinal pigment epithelial cells
Ryhänen T, Mannermaa E, Oksala N, Viiri J, Paimela T, Salminen A, Atalay M, Kaarniranta K. 2008. European journal of pharmacology. 584: 229-236 -
Regulation of ERalfa signaling pathway in neuronal HN10 cells: role of protein acetylation and Hsp90
Suuronen T, Ojala J, Hyttinen JMT, Kaarniranta K, Thornell A, Kyrylenko S, Salminen A. 2008. Neurochemical research. 33: 1768-1775 -
SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation?
Salminen A, Kauppinen A, Suuronen T, Kaarniranta K. 2008. Bioessays. 30: 939-942 -
Terpenoids: natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential
Salminen A, Lehtonen M, Suuronen T, Kaarniranta K, Huuskonen J. 2008. Cellular and molecular life sciences. 65: 2979-2999 -
Alpha-lipoic acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney
Oksala NKJ, Lappalainen J, Laaksonen DE, Khanna S, Kaarniranta K, Sen CK, Atalay M. 2007. Antioxidants and redox signaling. 9: 497-506 -
Corneal epithelium as a platform for secretion of transgene products after transfection with liposomal gene eyedrops
Toropainen E, Hornof M, Kaarniranta K, Johansson P, Urtti A. 2007. Journal of gene medicine. 9: 208-216 -
Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells
Suuronen T, Nuutinen T, Ryhänen T, Kaarniranta K, Salminen A. 2007. Biochemical and biophysical research communications. 357: 397-401 -
Imiquimod in the treatment of eyelid basal cell carcinoma
Leppälä J, Kaarniranta K, Uusitalo H, Kontkanen M. 2007. Acta ophthalmologica. 85: 566-568 -
In vitro biocompatibility of degradable biopolymers in cell line cultures from various ocular tissues:Direct contact studies
Huhtala A, Pohjonen T, Salminen L, Salminen A, Kaarniranta K, Uusitalo H. 2007. Journal of biomedical materials research part a. 83A: 407-413 -
Leucine 7-proline 7 polymorphism in the signal peptide of neuropeptide Y is not a risk factor for exudative age-related macular degeneration
Kaarniranta K, Holopainen JM , Karvonen MK, Koulu M, Kallio J, Pesonen U, Teräsvirta M, Uusitalo H, Immonen I. 2007. Acta ophthalmologica. 85: 188-191 -
Maculopathy in Pierre Robin sequences
Kaarniranta K, Tuppurainen K, Nikolajev K. 2007. Journal of pediatric ophthalmology and strabismus -
Matrix metalloproteinases and their inhibitors in the chamber angle of normal eyes and patients with primary open-angle glaucoma and exfoliation glaucoma
Rönkkö S, Rekonen P, Kaarniranta K, Puustjärvi T, Teräsvirta M, Uusitalo M. 2007. Graefes archive for clinical and experimental ophthalmology. 245: 697-704 -
Phospholipase A2 in chamber angle of normal eyes and patients with primary open angle glaucoma and exfoliation glaucoma
Rönkkö S, Rekonen P, Kaarniranta K, Puustjärvi T, Teräsvirta M, Uusitalo H. 2007. Molecular vision. 13: 408-417 -
Silmänpohjan nesteisen ikärappeuman uudet lääkkeet
Mannermaa E, Urtti A, Kaarniranta K. 2007. Duodecim. 123: 2229-2237 -
The effect of 17beta-estradiol on IL-6 secretion and NF-kappaB DNA-binding activity in human retinal pigment epithelial cells
Paimela T, Ryhänen T, Mannermaa E, Ojala J, Kalesnykas G, Salminen A, Kaarniranta K, Ojala J. 2007. Immunology letters. 110: 139-144 -
The expression of heat shock protein 27 in retinal ganglion and glial cells in a rat glaucoma model
Kalesnykas G, Niittykoski M, Rantala J, Miettinen R, Salminen A, Kaarniranta K, Uusitalo H. 2007. Neuroscience. 150: 692-704 -
A mouse model for Stickler's syndrome: Ocular phenotype of mice carrying a targeted heterozygous inactivation of type II (pro)collagen gene (Col2al)
Kaarniranta K, Ihanamäki T, Sahlman J, Pulkkinen H, Uusitalo H, Arita M, Tammi R, Lammi MJ, Helminen H. 2006. Experimental eye research. 83: 297-303 -
Analysis of variants in the complement factor H, the elongation of very long chain fatty acids-like 4 and the hemicentin 1 genes of age-related macular degeneration in the Finnish population
Seitsonen S, Lemmelä S, Holopainen J, Tommila P, Ranta P, Kotamies A, Moilanen J, Palosaari T, Kaarniranta K, Meri S, Immonen I, Järvelä I. 2006. Molecular vision. 12: 796-801 -
Immunolocalization of EMMPRIN (Cd147) in the human eye and detection of soluble form of EMMPRIN in ocular fluids
Määttä M, Tervahartiala T, Kaarniranta K, Tang Y, Yan L, Tuukkanen J, Sorsa T. 2006. Current eye research. 31: 917-924 -
Geldanamycin activates Hsp70 response and attenuates okadaic acid-induced cytotoxicity in human retinal pigment epithelial cells
Kaarniranta K, Ryhänen T, Sironen RK, Suuronen T, Elo MA, Karjalainen HM, Lammi MJ, Teräsvirta M, Uusitalo H, Salminen A. 2005. MOLECULAR BRAIN RESEARCH. 137: 126-131 -
Geldanamycin increases 4-hydroxynonenal (HNE)-induced cell death in human retinal pigment epithelial cells
Kaarniranta K, Ryhänen T, Karjalainen HM, Lammi MJ, Suuronen T, Huhtala A, Kontkanen M, Teräsvirta M, Uusitalo H, Salminen A. 2005. Neuroscience letters. 382: 185-190 -
Hsp90 inhibitor geldanamycin increases hsp70 mRNA stabilisation but fails to activate HSF1 in cells exposed to hydrostatic pressure
Elo MA, Kaarniranta K, Helminen HJ, Lammi MJ. 2005. Biochimica et biophysica acta: molecular cell research. 1743: 115-119 -
Solustressi yhdistyy silmänpohjan ikärappeumaan
Kaarniranta K. 2005. SILMÄHOITAJA. : 4-5 -
Hydrostatic pressure-induced changes in cellular protein syntheisis
Lammi MJ, Elo MA, Sironen RK, Karjalainen HM, Kaarniranta K, Helminen HJ. 2004. Biorheology. 41: 309-313 -
Gene expression profiles in chondrosarcoma cells subjected to cyclic stretching and hydrostatic pressure. A cDNA array study
Karjalainen HM, Sironen RK, Elo MA, Kaarniranta K, Takigawa M, Helminen HJ, Lammi MJ. 2003. Biorheology. 40: 93-100 -
Silmänpohjan ikärappeuma - vaikea ongelma sekä potilaalle että silmälääkärille
Kaarniranta K, Sihvola R, Salminen A, Lammi MJ, Teräsvirta M, Kontkanen M. 2003. Duodecim. 119: 935-942 -
Specific induction of heat shock protein 90 beta by high hydrostatic pressure
Elo MA, Sironen RK, Karjalainen HM, Kaarniranta K, Helminen HJ, Lammi MJ. 2003. Biorheology. 40: 141-146 -
Stress responses of mammalian cells to high hydrostatic pressure
Kaarniranta K, Elo MA, Sironen RK, Karjalainen HM, Helminen HJ, Lammi MJ. 2003. Biorheology. 40: 87-92 -
High pressure effects on cellular expression profile and mRNA stability. A cDNA array analysis
Sironen RK, Karjalainen HM, Törrönen K, Elo MA, Kaarniranta K, Takigawa M, Helminen HJ, Lammi MJ. 2002. Biorheology. 39: 111-117 -
Hyaluronan stimulates keratinocyte migration and activates the transcription factor AP-1 in keratinocytes through the JNK pathway
Törrönen K, Yabal M, Rilla K, Kaarniranta K, Tammi R, Lammi MJ, Tammi M. Teoksessa: Kennedy JF, Phillips GO, Williams PA, Hascall VC(toim.) , 2002. Hyaluronan. Chemical, Biochemical and Biological Aspects.. s. 551-556. Woodhead -
Neuronal cells show regulatory differences in the hsp70 gene response
Kaarniranta K, Oksala N, Karjalainen HM, Suuronen T, Sistonen L, Helminen HJ, Salminen A, Lammi MJ. 2002. MOLECULAR BRAIN RESEARCH. 101: 136-140 -
Regulatory Differences of the hsp70 Gene Response in Mammalian Cells
Kaarniranta K. 2002. Kuopio University Publications D. Medical Sciences -
cDNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure
Sironen RK, Karjalainen HM, Elo MA, Kaarniranta K, Törrönen K, Takigawa M, Helminen HJ, Lammi MJ. 2002. Biochimica et biophysica acta: molecular cell research. 1591: 45-54 -
Primary chondrocytes resist hydrostatic pressure-induced stress while primary synovial cells and fibroblasts show modified Hsp70 response
Kaarniranta K, Holmberg CI, Lammi MJ, Eriksson JE, Sistonen L, Helminen HJ. 2001. Osteoarthritis and cartilage. 9: 7-13 -
Responses of mammalian cells to mechanical forces
Lammi MJ, Sironen RK, Elo MA, Oksala N, Kaarniranta K, Karjalainen HM, Helminen HJ. Teoksessa: Pandalai SG(toim.) , 2001. Recent Research Developments in Biophysics and Biochemistry. s. 77-98. Research Signpost -
Solustressin tutkimuksesta kliinisiin läpimurtoihin?
Kaarniranta K, Oksala N, Lammi MJ, Helminen HJ, Sistonen L. 2001. Duodecim. 117: 2266-2272 -
Differential regulation of stress proteins by high hydrostatic pressure, heat shock, and unbalanced calcium homeostasis in chondrocytis cells
Elo MA, Sironen RK, Kaarniranta K, Auriola S, Helminen HJ, Lammi MJ. 2000. Journal of cellular biochemistry. 79: 610-619 -
Protein synthesis is required for stabilization of hsp70 mRNA upon exposure to both hydrostatic pressurization and elevated temperature
Kaarniranta K, Holmberg CI, Helminen HJ, Eriksson JE, Sistonen L, Lammi MJ. 2000. Febs letters. 475: 283-286 -
Transcriptional activation in chondrocytes submitted to hydrostatic pressure
Sironen R, Elo M, Kaarniranta K, Helminen HJ, Lammi MJ. 2000. Biorheology. 37: 85-93 -
Cytoskeleton and proteoglycan synthesis in chondrocytes under hydrostatic pressure
Parkkinen JJ, Lammi MJ, Jortikka MO, Inkinen RI, Kaarniranta K, Helminen HJ, Tammi MI. Teoksessa: Tanaka S, Hamanishi C(toim.) , 1999. Advances in Osteoarthritis. s. 21-34. Springer -
Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation
Kaarniranta K, Elo M, Sironen R, Lammi MJ, Goldring MB, Eriksson JE, Sistonen L, Helminen HJ. 1998. Proceedings of the National Academy of Sciences of the United States of America. 95: 2319-2324 -
Stage-specific expression and cellular localization of the heat shock factor 2 isoforms in the rat seminiferous epithelium
Alastalo T-P, Lönnström M, Leppä S, Kaarniranta K, Pelto-Huikko M, Sistonen L, Parvinen M. 1998. Experimental cell research. 240: 16-27