KAI KAARNIRANTA

Contact info

Publications

• Amirkavei, Mooud; Pitkänen, Marja; Kaikkonen, Ossi; Kaarniranta, Kai; André, Helder; Koskelainen, Ari. 2020. Induction of Heat Shock Protein 70 in Mouse RPE as an In Vivo Model of Transpupillary Thermal Stimulation International journal of molecular sciences 21 6: 2063. 2020
• Korhonen, Eveliina; Piippo, Niina; Hytti, Maria; Hyttinen, Juha; Kaarniranta, Kai; Kauppinen, Anu. 2020. Only IL-1ß release is inflammasome-dependent upon ultraviolet B irradiation although IL-18 is also secreted Faseb journal 34 5: 6437-6448. 2020
• Bhattarai, Niina; Korhonen, Eveliina; Toppila, Maija; Koskela, Ali; Kaarniranta, Kai; Mysore, Yashavanthi; Kauppinen, Anu. 2020. Resvega Alleviates Hydroquinone-Induced Oxidative Stress in ARPE-19 Cells International journal of molecular sciences 21 6: 2066. 2020
• Wedenoja, Juho; Kalsi, Juhani; Salenius, Salla; Parkkari, Kalle; Kaarniranta, Kai; Tervo, Timo. 2020. The role of vision-related problems in fatal road accidents in Finland Acta ophthalmologica [First published: 09 September 20]: 1-4. 2020
• Taipale, Claudia; Lindholm, Juha-Matti; Kaarniranta, Kai; Tuuminen, Raimo. 2020. Comparison of Two Different Treat-and-Extend Protocols with Afibercept in Wet Age-Related Macular Degeneration: Two-Year Results Advances in therapy 37: 2256-2266. 2020
• Sridevi Gurubaran, Iswariyaraja; Viiri, Johanna; Koskela, Ali; Hyttinen, Juha M; Paterno, Jussi; Kis, Gréta; Antal, Miklós; Urtti, Arto; Kauppinen, Anu; Felszeghy, Szabolcs; Kaarniranta, Kai. 2020. Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model International journal of molecular sciences 21 6: 1976. 2020
• Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2020. Exosomal vesicles enhance immunosuppression in chronic inflammation: Impact in cellular senescence and the aging process Cellular signalling In Press, Journal Pre-proof 9.9.20: 1-29. 2020
• Lehenkari, Petri; Tuovinen, Timo; Alahuhta, Seppo; Risteli, Leila; Ylöstalo, Pekka; Rämet, Mika; Parkkila, Seppo; Happo, Saara; Kaarniranta, Kai; Blom, Nina; Ritvos, Olli; Kähäri, Veli-Matti; Leivo, Ilmo; Heikinheimo, Markku. 2020. Yhtenäiset vaatimukset lääketieteen ja hammaslääketieteen tohtorintutkinnolle Suomessa Duodecim 136 6: 633-640. 2020
• Laihia, Jarmo; Kaarniranta, Kai. 2020. Trehalose for Ocular Surface Health Biomolecules 10 5: 809. 2020
• Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2020. ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease Journal of molecular medicine: jmm [Online ahead of print 11 April 20]: 1-18. 2020
• Korhonen, Eveliina; Bisevac, Jovana; Hyttinen, Juha MT; Piippo, Niina; Hytti, Maria; Kaarniranta, Kai; Petrovski, Goran; Kauppinen, Anu. 2020. UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells Investigative ophthalmology and visual science 61 4: 7. 2020
• Josifovska, N; Albert, R; Nagymihály, R; Lytvynchuk, L; Moe, MC; Kaarniranta, K; Veréb, ZJ; Petrovski, G. 2020. Resveratrol as Inducer of Autophagy, Pro-Survival, and Anti-Inflammatory Stimuli in Cultured Human RPE Cells International journal of molecular sciences 21 3: 813. 2020
• Kauppinen, Anu; Kaarniranta, Kai; Salminen, Antero. 2020. Potential Role of Myeloid-Derived Suppressor Cells (MDSCs) in Age-Related Macular Degeneration (AMD) Frontiers in immunology 11: 384. 2020
• Hellinen, Laura; Hongisto, Heidi; Ramsay, Eva; Kaarniranta, Kai; Vellonen, Kati-Sisko; Skottman, Heli; Ruponen, Marika. 2020. Drug Flux Across RPE Cell Models: The Hunt for An Appropriate Outer Blood-Retinal Barrier Model for Use in Early Drug Discovery Pharmaceutics 12 2: 176. 2020
• Hongisto, H; Dewing, JM; Christensen, DRG; Scott, J; Cree, AJ; Nättinen, J; Määttä, J; Jylhä, A; Aapola, U; Uusitalo, H; Kaarniranta, K; Ratnayaka, JA; Skottman, H; Lotery, AJ. 2020. In vitro stem cell modelling demonstrates a proof-of-concept for excess functional mutant TIMP3 as the cause of Sorsby Fundus Dystrophy Journal of pathology First published: 15 July 2020: -. 2020
• Blasiak, Janusz; Pawlowska, Elzbieta; Chojnacki, Jan; Szczepanska, Joanna; Chojnacki, Cezary; Kaarniranta, Kai. 2020. Zinc and Autophagy in Age-Related Macular Degeneration International journal of molecular sciences 21 14: 4994. 2020
• Kaarniranta, Kai; Pawlowska, Elzbieta; Szczepanska, Joanna; Blasiak, Janusz. 2020. DICER1 in the Pathogenesis of Age-related Macular Degeneration (AMD) - Alu RNA Accumulation versus miRNA Dysregulation Aging and disease 11 4: 851-862. 2020
• Kaarniranta, Kai; Uusitalo, Hannu; Blasiak, Janusz; Felszeghy, Szabolcs; Kannan, Ram; Kauppinen, Anu; Salminen, Antero; Sinha, Debasish; Ferrington, Deborah. 2020. Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration Progress in retinal and eye research [Online ahead of print 2020 Apr 13]: 1-19. 2020
• Karesvuo, Petteri; Hakkala, Laura; Kaarniranta, Kai; Uusitalo, Hannu; Ojamo, Matti; Tuuminen, Raimo. 2020. Correlation Between the Rate of Intravitreal Injections, Use of Aflibercept as a Second-Line Treatment and Visual Impairment for Wet AMD in Finland Acta ophthalmologica [Epub ahead of print 24 Feb 2020]: 1-5. 2020
• Korhonen, E; Piippo, N; Hytti, M; Hyttinen, JMT; Kaarniranta, K; Kauppinen, A. 2019. SQSTM1/p62 regulates the production of IL-8 and MCP-1 in IL-1ß-stimulated human retinal pigment epithelial cells Cytokine 116: 70-77. 2019
• Zeiner, J; Loukovaara, S; Losenkova, K; Zuccarini, M; Korhonen, AM; Lehti, K; Kauppinen, A; Kaarniranta, K; Müller, CE; Jalkanen, S; Yegutkin, GG. 2019. Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage Journal of molecular medicine: jmm 97 3: 341-354. 2019
• Tuuminen, R; Sipilä, R; Komulainen, J; Saarela, V; Kaarniranta, K; Tuulonen, A. 2019. The first ophthalmic Choosing Wisely recommendations in Finland for glaucoma and wet age-related macular degeneration Acta ophthalmologica 97 5: e808-e810. 2019
• Szatmári-Tóth, M; Ilmarinen, T; Mikhailova, A; Skottman, H; Kauppinen, A; Kaarniranta, K; Kristóf, E; Lytvynchuk, L; Veréb, Z; Fésüs, L; Petrovski, G. 2019. Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium-Role in Dead Cell Clearance and Inflammation International journal of molecular sciences 20 4: 926. 2019
• Smedowski, A; Akhtar, S; Liu, X; Pietrucha-Dutczak, M; Podracka, L; Toropainen, E; Alkanaan, A; Ruponen, M; Urtti, A; Varjosalo, M; Kaarniranta, K; Lewin-Kowalik, J. 2019. Electrical synapses interconnecting axons revealed in the optic nerve head - a novel model of gap junctions' involvement in optic nerve function Acta ophthalmologica [Epub ahead of print 10 Oct 2019]: 1-10. 2019
• Salminen, Antero; Kauppinen, Anu; Kaarniranta, Kai. 2019. AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging Journal of molecular medicine: jmm 97 8: 1049-1064. 2019
• Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2019. Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency Cellular and molecular life sciences 76 10: 1901-1918. 2019
• Resvega alleviates oxidative stress and inflammasome activation in retinal pigment epithelial cells. Bhattarai, Niina; Korhonen, Eveliina; Toppila, Maija; Kaarniranta, Kai; Kauppinen, Anu. Acta ophthalmologica. 2019. 2019
• Laihia, J; Järvinen, R; Wylegala, E; Kaarniranta, K. 2019. Disease aetiology-based design of multifunctional microemulsion eye drops for moderate or severe dry eye: a randomized, quadruple-masked and active-controlled clinical trial Acta ophthalmologica 2020; 98 3: 244-254. 2019
• Pawlowska, E; Szczepanska, J; Koskela, A; Kaarniranta, K; Blasiak, J. 2019. Dietary Polyphenols in Age-Related Macular Degeneration: Protection against Oxidative Stress and Beyond Oxidative medicine and cellular longevity 2019: 9682318. 2019
• Kiamehr, M; Klettner, A; Richert, E; Koskela, A; Koistinen, A; Skottman, H; Kaarniranta, K; Aalto-Setälä, K; Juuti-Uusitalo, K. 2019. Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients International journal of molecular sciences 20 15: 3773. 2019
• Hytti, Maria; Korhonen, Eveliina; Hyttinen, Juha M T; Roehrich, Heidi; Kaarniranta, Kai; Ferrington, Deborah A; Kauppinen, Anu. 2019. Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy Oxidative medicine and cellular longevity 2019: 1583656. 2019
• Karttunen, Tommi; Nummelin, Lasse; Kaarniranta, Kai; Kinnunen, Kati. 2019. Real Life Experience of Dexamethasone Implant in Refractory Diabetic Macular Oedema Clinical ophthalmology 13: 2583-2590. 2019
• Blasiak, J; Pawlowska, E; Szczepanska, J; Kaarniranta, K. 2019. Interplay between Autophagy and the Ubiquitin-Proteasome System and Its Role in the Pathogenesis of Age-Related Macular Degeneration International journal of molecular sciences 20 1: 210. 2019
• Blasiak, J; Watala, C; Tuuminen, R; Kivinen, N; Koskela, A; Uusitalo-Järvinen, H; Tuulonen, A; Winiarczyk, M; Mackiewicz, J; Zmorzynski, S; Filip, A; Kaarniranta, K. 2019. Expression of VEGFA-regulating miRNAs and mortality in wet AMD Journal of cellular and molecular medicine 23 12: 8464-8471. 2019
• Bourne, RRA; Kaarniranta, K; Lorenz, K; Traverso, CE; Vuorinen, J; Ropo, A. 2019. Changes in ocular signs and symptoms in patients switching from bimatoprost-timolol to tafluprost-timolol eye drops: an open-label phase IV study BMJ open 9: e024129. 2019
• Aro, A; Kauppinen, A; Kivinen, N; Selander, T; Kinnunen, K; Tuomilehto, J; Keinänen-Kiukaanniemi, S; Lindström, J; Uusitupa, M; Kaarniranta, K. 2019. Life Style Intervention Improves Retinopathy Status - The Finnish Diabetes Prevention Study Nutrients 11 7: 1691. 2019
• Hyttinen, JMT; Kannan, R; Felszeghy, S; Niittykoski, M; Salminen, A; Kaarniranta, K. 2019. The Regulation of NFE2L2 (NRF2) Signalling and Epithelial-to-Mesenchymal Transition in Age-Related Macular Degeneration Pathology International journal of molecular sciences 20 22: 5800. 2019
• Kaarniranta, K; Pawlowska, E; Szczepanska, J; Jablkowska, A; Blasiak, J. 2019. Can vitamin D protect against age-related macular degeneration or slow its progression? Acta biochimica polonica 66 2: 147-158. 2019
• Kaarniranta, K; Pawlowska, E; Szczepanska, J; Jablkowska, A; Blasiak, J. 2019. Role of Mitochondrial DNA Damage in ROS-Mediated Pathogenesis of Age-Related Macular Degeneration (AMD). International journal of molecular sciences 20 10: 2374. 2019
• Kaarniranta, Kai; Koskela, Ali; Felszeghy, Szabolcs; Kivinen, Niko; Salminen, Antero; Kauppinen, Aanu. 2019. Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration Biochimie 159: 49-54. 2019
• Seppänen, Matti; Kaarniranta, Kai. 2018. Atselastiini. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 469. 2018
• Seppänen, Matti; Kaarniranta, Kai. 2018. Levokabastiini. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 471-472. 2018
• Seppänen, Matti; Kaarniranta, Kai. 2018. Atsitromysiini. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 434. 2018
• Seppänen, Matti; Kaarniranta, Kai. 2018. Dinatriumkromoglikaatti. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 470-471. 2018
• Seppänen, Matti; Kaarniranta, Kai. 2018. Emedastiini. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 470. 2018
• Seppänen, Matti; Kaarniranta, Kai. 2018. Fluorokinolonit. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 434-435. 2018
• Seppänen, Matti; Kaarniranta, Kai. 2018. Fusidiinihappo. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 435-436. 2018
• Seppänen, Matti; Kaarniranta, Kai. 2018. Gansikloviiri. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 436-437. 2018
• Seppänen, Matti; Kaarniranta, Kai. 2018. Kefuroksiimi. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 437. 2018
• Seppänen, Matti; Kaarniranta, Kai. 2018. Klooritetrasykliini. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 437-438. 2018
• Seppänen, Matti; Kaarniranta, Kai. 2018. Kloramfenikoli. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 438-439. 2018
• Seppänen, Matti; Kaarniranta, Kai. 2018. Tobramysiini. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 440-441. 2018
• Seppänen, Matti; Kaarniranta, Kai. 2018. Lodoksamidi. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 472. 2018
• Seppänen, Matti; Kaarniranta, Kai. 2018. Natamysiini. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 439-440. 2018
• Seppänen, Matti; Kaarniranta, Kai. 2018. Olopatadiini. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 472-473. 2018
• Seppänen, Matti; Kaarniranta, Kai. 2018. Propamidiini. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 440. 2018
• Seppänen, Matti; Kaarniranta, Kai. 2018. Siklosporiini. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 480-481. 2018
• Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. 2018. Silmävärve (nystagmus). In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 290-291. 2018
• Seppänen, Matti; Setälä, Niko; Kaarniranta, Kai. 2018. Asikloviiri. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 433-434. 2018
• Silmätautien käsikirja. Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. 2018 2018
• Special issue on Molecular Mechanisms Underlying Age-Related Ocular Diseases. Amadio, Marialaura; Kaarniranta, Kai; Xu, Heping; Smedowski, Adrian; Ferrington, Deborah A. 2018 2018
• Winiarczyk, Mateusz; Kaarniranta, Kai; Winiarczyk, Stanislaw; Adaszek, Lukasz; Winiarczyk, Dagmara; Mackiewicz, Jerzy. 2018. Tear film proteome in age-related macular degeneration GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 256 6: 1127-1139. 2018
• Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2018. The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process AGEING RESEARCH REVIEWS 48: 1-10. 2018
• Salminen, Antero; Kauppinen, Anu; Kaarniranta, Kai. 2018. Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence Biogerontology 19 5: 325-329. 2018
• Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. 2018. Ajokorttitodistusten näkövaatimukset. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 376. 2018
• Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2018. The potential importance of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of Alzheimer's disease Cellular and molecular life sciences 75 17: 3099-3120. 2018
• Kaarniranta, Kai. 2018. Verkkokalvohalkio. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 182-183. 2018
• Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2018. Phytochemicals inhibit the immunosuppressive functions of myeloid-derived suppressor cells (MDSC): Impact on cancer and age-related chronic inflammatory disorders. International Immunopharmacology 61: 231-240. 2018
• Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. 2018. Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration Redox biology 2019; 20: 1-12. 2018
• Hyttinen, Juha MT; Viiri, Johanna; Kaarniranta, Kai; Blasiak, Janusz. 2018. Mitochondrial quality control in AMD: does mitophagy play a pivotal role? Cellular and molecular life sciences 75 16: 2991-3008. 2018
• Ilmarinen, T; Thieltges, F; Hongisto, H; Juuti-Uusitalo, K; Koistinen, A; Kaarniranta, K; Brinken, R; Braun, N; Holz, FG; Skottman, H; Stanzel, BV. 2018. Survival and functionality of xeno-free human embryonic stem cell-derived retinal pigment epithelial cells on polyester substrate after transplantation in rabbits Acta ophthalmologica 2019; 97 5: e688-e699. 2018
• Kaarniranta, Kai. 2018. Bestin tauti. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 194-195. 2018
• Kaarniranta, Kai. 2018. Fluoreseiiniangiografia (FAG). In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 394-395. 2018
• Amadio, Marialaura; Kaarniranta, Kai; Xu, Heping; Smedowski, Adrian; Ferrington, Deborah A. 2018. Molecular Mechanisms Underlying Age-Related Ocular Diseases Oxidative Medicine and Cellular Longevity 2018: 1-2. 2018
• Kaarniranta, Kai. 2018. Mikrobinäytteen otto silmästä. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 407-409. 2018
• Kaarniranta, Kai. 2018. Optinen valokerroskuvaus (OCT). In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 396-397. 2018
• Kaarniranta, Kai. 2018. Silmänpohjan ikärappeumat. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 192-194. 2018
• Kaarniranta, Kai. 2018. Fotodynaaminen hoito (PDT). In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 422. 2018
• Kaarniranta, Kai; Kajdanek, Jakub; Morawiec, Jan; Pawlowska, Elzbieta; Blasiak, Janusz. 2018. PGC-1alfa Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD Pathogenesis INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19 8: 2317. 2018
• Lappalainen, J; Oksala, NKJ; Laaksonen, DE; Khanna, S; Kokkola, T; Kaarniranta, K; Sen, CK; Atalay, M. 2018. Suppressed heat shock protein response in the kidney of exercise-trained diabetic rats SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS 28 7: 1808-1817. 2018
• Kaarniranta, Kai; Marttila, Liisa; Seppänen, Matti. 2018. Leikkauksenjälkeisen silmämunan sisäosien yleistulehduksen hoito. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 185-188. 2018
• Piippo, Niina; Korhonen, Eveliina; Hytti, Maria; Kinnunen, Kati; Kaarniranta, Kai; Kauppinen, Anu. 2018. Oxidative Stress is the Principal Contributor to Inflammasome Activation in Retinal Pigment Epithelium Cells with Defunct Proteasomes and Autophagy Cellular physiology and biochemistry 49 1: 359-367. 2018
• Piippo, N; Korhonen, E; Hytti, M; Skottman, H; Kinnunen, K; Josifovska, N; Petrovski, G; Kaarniranta, K; Kauppinen, A. 2018. Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome. Scientific Reports 8: 6720. 2018
• Marchesi, Nicoletta; Thongon, Natthakan; Pascale, Alessia; Provenzani, Alessandro; Koskela, Ali; Korhonen, Eveliina; Smedowski, Adrian; Govoni, Stefano; Kauppinen, Anu; Kaarniranta, Kai; Amadio, Marialaura. 2018. Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways Oxidative medicine and cellular longevity 2018: 4956080. 2018
• Ruotsalainen, Anna-Kaisa; Lappalainen, Jari P; Heiskanen, Emmi; Merentie, Mari; Näpänkangas, Juha; Lottonen-Raikaslehto, Line; Kansanen, Emilia; Adinolfi, Simone; Kaarniranta, Kai; Ylä-Herttuala, Seppo; Jauhiainen, Matti; Pirinen, Eija; Levonen, Anna-Liisa. 2018. Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolemic mice CARDIOVASCULAR RESEARCH 2019; 115 1: 243-254. 2018
• Kivinen, Niko; Tuulonen, Anja; Kaarniranta, Kai. 2018. Silmänpohjan kuvantaminen yleistyy ja tarkentuu Duodecim 134 12: 1235-1243. 2018
• Kivinen, Niko; Kaarniranta, Kai. 2018. Seroosi retinopatia, nesteinen keskeisen verkkokalvon sairaus Lääkärilehti 73 36: 1940-1943. 2018
• Khamidakh, Amna E Abu; Rodriguez-Martinez, Alejandra; Kaarniranta, Kai; Kallioniemi, Anne; Skottman, Heli; Hyttinen, Jari; Juuti-Uusitalo, Kati. 2018. Wound healing of human embryonic stem cell-derived retinal pigment epithelial cells is affected by maturation stage Biomedical engineering online 17: 102. 2018
• Kaarniranta; Kai; Xu, Heping; Kauppinen, Anu. 2018. Mechanistical retinal drug targets and challenges Advanced drug delivery reviews 126: 177-184. 2018
• Kivinen, Niko; Kaarniranta, Kai; Seppänen, Matti. 2018. Verkkokalvon keskeinen nesteirtauma. In: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (ed.) Silmätautien käsikirja. Duodecim. s. 184-185. 2018
• Skottman H, Muranen J, Lähdekorpi H, Pajula E, Mäkelä K, Koivusalo L, Koistinen A, Uusitalo H, Kaarniranta K, Juuti-Uusitalo K. 2017. Contacting co-culture of human retinal microvascular endothelial cells alters barrier function of human embryonic stem cell derived retinal pigment epithelial cells. EXPERIMENTAL CELL RESEARCH 359 1: 101-111. 2017
• Roginska Dorota, Kawa Milosz P, Pius-Sadowska Ewa, Lejkowska Renata, Luczkowska Karolina, Wiszniewska Barbara, Kaarniranta Kai, Paterno Jussi J, Schmidt Christian A, Machalinski Boguslaw, Machalinska Anna. 2017. Depletion of the Third Complement Component Ameliorates Age-Dependent Oxidative Stress and Positively Modulates Autophagic Activity in Aged Retinas in a Mouse Model Oxidative medicine and cellular longevity 2017: 5306790. 2017
• Salminen A, Kaarniranta K, Kauppinen A. 2017. Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity. CELLULAR SIGNALLING 40: 10-21. 2017
• Salminen Antero, Kaarniranta Kai, Kauppinen Anu. 2017. Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses. AGEING RESEARCH REVIEWS 37: 79-93. 2017
• Salminen Antero, Kauppinen Anu, Kaarniranta Kai. 2017. Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease. JOURNAL OF NEUROCHEMISTRY 140 4: 536-549. 2017
• Tuuminen R, Tuulonen A, Kaarniranta K. 2017. The Finnish national guideline for diagnosis, treatment and follow-up of patients with wet age-related macular degeneration. ACTA OPHTHALMOLOGICA 95 7: 649-650. 2017
• Smedowski A, Liu X, Podracka L, Akhtar S, Trzeciecka A, Pietrucha-Dutczak M, Lewin-Kowalik J, Urtti A, Ruponen M, Kaarniranta K, Varjosalo M, Amadio M. 2017. Increased intraocular pressure alters the cellular distribution of HuR protein in retinal ganglion cells : a possible sign of endogenous neuroprotection failure. Biochimica et Biophysica Acta: Molecular Basis of Disease 2018; 1864 1: 296-306. 2017
• Smedowski A, Tarnawska D, Orski M, Wroblewska-Czajka E, Kaarniranta K, Aragona P, Wylegala E. 2017. Cytoarchitecture of epithelial inflammatory infiltration indicates the aetiology of infectious keratitis. ACTA OPHTHALMOLOGICA 95 4: 405-413. 2017
• Tuuminen Raimo, Uusitalo-Järvinen Hannele, Aaltonen Vesa, Hautala Nina, Kaipiainen Sulevi, Laitamäki Nina, Ollila Marko, Rantanen Jari, Välimäki Satu, Sipilä Raija, Laukkala Tanja, Komulainen Jorma, Tommila Petri, Immonen Ilkka, Tuulonen Anja, Kaarniranta Kai. 2017. The Finnish national guideline for diagnosis, treatment and follow-up of patients with wet age related macular degeneration. ACTA OPHTHALMOLOGICA 95 A105: 1-9. 2017
• Vottonen Pasi, Kaarniranta Kai, Pääkkönen Ari, Tarkka Ina M. 2017. Visual processing in patients with age-related macular degeneration performing a face detection test. Clinical Ophthalmology 11: 1245-1252. 2017
• Penttilä E, Smirnov G, Kaarniranta K, Seppä J, Tuomilehto H. 2017. Predictive factors in endonasal endoscopic lacrimal surgery: a review. B-ENT 13: 129-135. 2017
• Petrovski G, Kaarniranta K, Petrovic D. 2017. Oxidative Stress, Epigenetics, Environment, and Epidemiology of Diabetic Retinopathy. Journal of Diabetes Research [Published online 2017 Feb 22]: 1-2. 2017
• Hytti M, Szabó D, Piippo N, Korhonen E, Honkakoski P, Kaarniranta K, Petrovski G, Kauppinen A. 2017. Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cell. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 42: 37-42. 2017
• Loukovaara S, Piippo N, Kinnunen K, Hytti M, Kaarniranta K, Kauppinen A. 2017. NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy. ACTA OPHTHALMOLOGICA 95 8: 803-808. 2017
• Hytti M, Andjelic S, Josifovska N, Piippo N, Korhonen E, Hawlina M, Kaarniranta K, Nevalainen TJ, Petrovski G, Parkkari T, Kauppinen A. 2017. CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells. Scientific Reports 7 1: 16169. 2017
• Arjamaa Olli, Aaltonen Vesa, Piippo Niina, Csont Tamás, Petrovski Goran, Kaarniranta Kai, Kauppinen Anu. 2017. Hypoxia and inflammation in the release of VEGF and interleukins from human retinal pigment epithelial cells. GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 255 9: 1757-1762. 2017
• Blasiak Janusz, Piechota Malgorzata, Pawlowska Elzbieta, Szatkowska Magdalena, Sikora Ewa, Kaarniranta Kai. 2017. Cellular Senescence in Age-Related Macular Degeneration: Can Autophagy and DNA Damage Response Play a Role?. Oxidative Medicine and Cellular Longevity 2017: 5293258. 2017
• Kivinen Niko, Koskela Ali, Kauppinen Anu, Kaarniranta kai. 2017. Silmänpohjan ikärappeuman patogeneesi - autofagian ja inflammasomien vuoropuhelua. DUODECIM 133 7: 641-646. 2017
• Helin-Toiviainen M, Rönkkö S, Kaarniranta K, Puustjärvi T, Rekonen P, Ollikainen M, Uusitalo H. 2017. Oxidized low-density lipoprotein, lipid and calcium aggregates reveal oxidative stress and inflammation in the conjunctiva of glaucoma patients. ACTA OPHTHALMOLOGICA 95 4: 378-385. 2017
• Dragoni, Francesco; Kaarniranta, Kai. 2017. Individual benefits of enoxaparin treatment in branch vein occlusion GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 2018; 256 5: 1031-1033. 2017
• Hyttinen JMT, Blasiak J, Niittykoski M, Kinnunen K, Kauppinen A, Salminen A, Kaarniranta K. 2017. DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells - Implications for age-related macular degeneration (AMD). AGEING RESEARCH REVIEWS 36: 64-77. 2017
• Jauhonen HM, Laihia J, Oksala O, Viiri J, Sironen R, Alajuuma P, Kaarniranta K, Leino L. 2017. Topical cis-urocanic acid prevents ocular surface irritation in both IgE -independent and -mediated rat model. GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 255 12: 2357-2362. 2017
• Juuti-Uusitalo K, Koskela A, Kivinen N, Viiri J, Hyttinen JMT, Reinisalo M, Koistinen A, Uusitalo H, Sinha D, Skottman H, Kaarniranta K. 2017. Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18 5: 1089. 2017
• Kaarniranta Kai, Petrovski Goran, Kauppinen Anu. 2017. The Nobel Prized cellular target autophagy in eye diseases. ACTA OPHTHALMOLOGICA 95 4: 335-336. 2017
• Kataja, M; Hujanen, P; Huhtala, H; Kaarniranta, K; Tuulonen, A; Uusitalo-Jarvinen, H. 2017. Outcome of anti-vascular endothelial growth factor therapy for neovascular age-related macular degeneration in real-life setting British journal of ophthalmology 2018; 102 7: 959-965. 2017
• Kinnunen K, Piippo N, Loukovaara S, Hytti M, Kaarniranta K, Kauppinen A. 2017. Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs). Journal of Cell Communication and Signaling 11 3: 275-279. 2017
• Salminen Antero, Kaarniranta Kai, Kauppinen Anu. 2016. AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms. BIOGERONTOLOGY 17 4: 655-680. 2016
• Uusitalo Hannu, Egorov Evjeniy, Kaarniranta Kai, Astakhov Yuri, Ropo Auli. 2016. Benefits of switching from latanoprost to preservative-free tafluprost eye drops: a meta-analysis of two Phase IIIb clinical trials. Clinical Ophthalmology 10: 445-454. 2016
• Tuuminen R, Uusitalo-Järvinen H, Aaltonen V, Hautala N, Kaipiainen S, Laitamäki N, Ollila M, Rantanen J, Välimäki S, Sipilä R, Laukkala T, Komulainen J, Tommila P, Immonen I, Tuulonen A, Kaarniranta K. 2016. Kostea silmänpohjan ikärappeuma (AMD). In: - (ed.) Käypä hoito. Suomalaisen Lääkäriseuran Duodecimin ja Suomen Fysiatriyhdistyksen asettama työryhmä. Duodecim. s. -. 2016
• Trzeciecka Anna, Paterno J Jussi, Toropainen Elisa, Koskela Ali, Podracka Lucia, Korhonen Eveliina, Kauppinen Anu, Kaarniranta Kai, Smedowski Adrian. 2016. Long-term topical application of preservative-free prostaglandin analogues evokes macrophage infiltration in the ocular adnexa European journal of pharmacology 788: 12-20. 2016
• Tokarz Paulina, Piastowska-Ciesielska Agnieszka Wanda, Kaarniranta Kai, Blasiak Janusz. 2016. All-Trans Retinoic Acid Modulates DNA Damage Response and the Expression of the VEGF-A and MKI67 Genes in ARPE-19 Cells Subjected to Oxidative Stress. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 17 6: 898. 2016
• Tokarz Paulina, Kaarniranta Kai, Blasiaka Janusz. 2016. Inhibition of DNA methyltransferase or histone deacetylase protects retinal pigment epithelial cells from DNA damage induced by oxidative stress by the stimulation of antioxidant enzymes. EUROPEAN JOURNAL OF PHARMACOLOGY 776: 167-175. 2016
• Szatmári-Tóth M, Kristóf E, Veréb Z, Akhtar S, Facskó A, Fésus L, Kauppinen A, Kaarniranta K, Petrovski G. 2016. Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration. Cell Death and Disease 7 9: e2367. 2016
• Salminen Antero, Kauppinen Anu, Kaarniranta Kai. 2016. FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process. JOURNAL OF MOLECULAR MEDICINE 2017; 95 2: 123-131. 2016
• Salminen Antero, Kauppinen Anu, Kaarniranta Kai. 2016. AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions. CELLULAR SIGNALLING 28 8: 887-895. 2016
• Salminen Antero, Kaarniranta Kai, Kauppinen Anu. 2016. Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases. Aging and disease 7 2: 180-200. 2016
• Dry Eye Disease - Nordic Guidelines 2016. Heegaard S, Knudsen LL, van Setten G, Koranyi G, Holopainen J, Kaarniranta K, Klyve P, Raeder S. 2016 2016
• Salminen Antero, Kaarniranta Kai, Kauppinen Anu. 2016. Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways. AGEING RESEARCH REVIEWS 28: 15-26. 2016
• Kaarniranta Kai, Meri Seppo, Eskelinen Eeva-Liisa. 2016. Lääketieteen Nobelin palkinto autofagian tutkijalle. DUODECIM 132 22: 2141-2144. 2016
• Hytti Maria, Tokarz P, Määttä E, Piippo Niina, Korhonen Eveliina, Suuronen T, Honkakoski Paavo, Kaarniranta Kai, Lahtela-Kakkonen Maija, Kauppinen Anu. 2016. Inhibition of BET bromodomains alleviates inflammation in human RPE cells. BIOCHEMICAL PHARMACOLOGY 110-111: 71-79. 2016
• Kaarniranta K, Tokarz P, Koskela A, Paterno J, Blasiak J. 2016. Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration Cell biology and toxicology 2017; 33: 113-128. 2016
• Blasiak J, Reiter RJ, Kaarniranta K. 2016. Melatonin in retinal physiology and pathology: the case of age-related macular degeneration. Oxidative Medicine and Cellular Longevity 2016: 6819736, 12 pages. 2016
• Kauppinen Anu, Paterno Jussi J, Blasiak Janusz, Salminen Antero, Kaarniranta Kai. 2016. Inflammation and its role in age-related macular degeneration Cellular and molecular life sciences 73 9: 1765-1786. 2016
• Kivinen Niko, Felszeghy Szabolcs, Kinnunen Aino I, Setälä Niko, Aikio Mari, Kinnunen Kati, Sironen Reijo, Pihlajaniemi Taina, Kauppinen Anu, Kaarniranta Kai. 2016. Absence of collagen XVIII in mice causes age-related insufficiency in retinal pigment epithelium proteostasis. BIOGERONTOLOGY 17 4: 749-761. 2016
• Klionsky Daniel J, Abdelmohsen Kotb, Abe Akihisa, Abedin Md Joynal, Abeliovich Hagai, Acevedo Arozena Abraham, Adachi Hiroaki, Adams Christopher M, Adams Peter D, Adeli Khosrow, Adhihetty Peter J, Adler Sharon G, Agam Galila, Agarwal Rajesh, Aghi Manish K, Agnello Maria, Agostinis Patrizia, Aguilar Patricia V, Aguirre-Ghiso Julio, Airoldi Eduardo M et al. 2016. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). AUTOPHAGY 12 1: 1-222. 2016
• Koskela Ali, Reinisalo Mika, Petrovski Goran, Sinha Debasish, Olmiere Céline, Karjalainen Reijo, Kaarniranta Kai. 2016. Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells. Nutrients 8 5: 284. 2016
• Paterno J, Ikäheimo K, Kinnunen K, Kaarniranta K. 2016. Nya behandlingar vid synhotande makulasjukdomer Finska läkaresällskapets handlingar 176 1: 10-14. 2016
• Penttilä Elina, Smirnov Grigori, Tuomilehto Henri, Kaarniranta Kai, Seppä Juha. 2015. Endoscopic dacryocystorhinostomy as treatment for lower lacrimal pathway obstructions in adults : Review article. Allergy and Rhinology 6 1: e12-e19. 2015
• Vottonen Pasi, Pääkkönen Ari, Tarkka Ina M, Kaarniranta Kai. 2015. Best-corrected visual acuity and retinal thickness are associated with improved cortical visual processing in treated wet AMD patients. ACTA OPHTHALMOLOGICA 93 7: 621-25. 2015
• Tokarz Paulina, Kaarniranta Kai, Blasiak Janusz. 2015. Role of the cell cycle re-initiation in DNA damage response of post-mitotic cells and its implication in the pathogenesis of neurodegenerative diseases. REJUVENATION RESEARCH 19 2: 1-9. 2015
• Sinha Debasish, Valapala Mallika, Shang Peng, Hose Stacey, Grebe Rhonda, Lutty Gerard A, Zigler Jr J Samuel, Kaarniranta Kai, Handa James T. 2015. Lysosomes: Regulators of autophagy in the retinal pigmented epithelium. EXPERIMENTAL EYE RESEARCH 144 (2016): 46-53. 2015
• Serra Horacio M, Holopainen Juha M, Beuerman Roger, Kaarniranta Kai, Suarez Maria F, Urrets-Zavalia Julio A. 2015. Climatic droplet keratopathy: an old disease in new clothes. ACTA OPHTHALMOLOGICA 93 6: 496-504. 2015
• Salminen Antero, Kauppinen Anu, Kaarniranta Kai. 2015. 2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process. CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS 72 20: 3897-3914. 2015
• Salminen Antero, Haapasalo Annakaisa, Kauppinen Anu, Kaarniranta Kai, Soininen Hilkka, Hiltunen Mikko. 2015. Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape. PROGRESS IN NEUROBIOLOGY epub ahead of print 19 May 2015. 2015
• Reinisalo Mika, Kårlund Anna, Koskela Ali, Kaaniranta Kai, Karjalainen Reijo O.. 2015. Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases. Oxidative Medicine and Cellular Longevity 2015, Article ID 340520: 24 p.. 2015
• Porela-Tiihonen Susanna, Roine Risto P, Sintonen Harri, Kaarniranta Kai, Kokki Merja, Kokki Hannu. 2015. Health-related quality of life after caract surgery with the phacoemulsification technique and intraocular lens implantation. ACTA OPHTHALMOLOGICA 2016; 94 1: 21-25. 2015
• Lumi Xhevat, Hawlina Marko, Glavac Damjan, Facsko Andrea, Moe Morten C, Kaarniranta Kai, Petrovski Goran. 2015. Ageing of the vitreous: From acute onset floaters and flashes to retinal detachment. AGEING RESEARCH REVIEWS 21: 71-77. 2015
• Kaarniranta Kai, Szalai Eszter, Smedowski Adrian, Hegyi Zoltán, Kivinen Niko, Viiri Johanna, Wowra Bogumil, Dobrowolski Dariusz, Módis Jr. László, Berta András, Wylegala Edward, Felszeghy Szabolcs. 2015. A novel proteotoxic stress associated mechanism for macular corneal dystrophy. HISTOLOGY AND HISTOPATHOLOGY 30: 921-930. 2015
• Kaarniranta Kai, Ikäheimo Kirsi, Mannermaa Eliisa, Ropo Auli. 2015. Pharmacokinetics, Efficacy, and Safety of the Preservative-free Fixed Combination of Tafluprost 0.0015 % and Timolol 0.5 % in Healthy Volunteers: A Phase I Comparison vs. the Corresponding Preservative-free Monotherapies. CLINICAL PHARMACOKINETICS [epub ahead of print 21 Sep 2015]: 1-10. 2015
• Johansson Ida, Monsen Vivi Talstad, Pettersen Kristine, Mildenberger Jennifer, Misund Kristine, Kaarniranta Kai, Schønberg Svanhild, Bjørkøy Geir. 2015. The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells. AUTOPHAGY 11 9: 1636-1651. 2015
• Jauhonen Hanna-Mari, Kari Eeva, Pylkkänen Liisa, Poutanen Jutta, Laihia Jarmo, Kaarniranta Kai, Leino Lasse. 2015. A randomized phase I clinical study of cis-urocanic acid eye drops in healthy adult subjects. ACTA OPHTHALMOLOGICA 93 4: 368-376. 2015
• Hytti Maria, Piippo Niina, Salminen Antero, Honkakoski Paavo, Kaarniranta Kai, Kauppinen Anu. 2015. Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells. EXPERIMENTAL EYE RESEARCH 132: 208-215. 2015
• Hytti Maria, Piippo Niina, Korhonen Eveliina, Honkakoski Paavo, Kaarniranta Kai, Kauppinen Anu. 2015. Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation. Scientific Reports 5 17645 (2015). 2015
• Ferrington Deborah A, Sinha Debasish, Kaarniranta Kai. 2015. Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration. PROGRESS IN RETINAL AND EYE RESEARCH 2016; 51: 69-89. 2015
• Czarny Piotr, Pawlowska Elzbieta, Bialkowska-Warzecha Jolanta, Kaarniranta Kai, Blasiak Janusz. 2015. Autophagy in DNA Damage Response. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16 2: 2641-2662. 2015
• Karttunen Tommi, Kaarniranta Kai, Kinnunen Kati. 2015. Diabeettisen retinopatian uudet hoidot ja diagnostiikka. DIABETES JA LÄÄKÄRI 44 4 (syyskuu): 17-22. 2015
• Salminen Antero, Kaarniranta Kai, Hiltunen Mikko, Kauppinen Anu. 2014. Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process. JOURNAL OF MOLECULAR MEDICINE -: -. 2014
• Piippo N, Korkmaz A, Hytti M, Kinnunen K, Salminen A, Atalay M, Kaarniranta K, Kauppinen A. 2014. Decline in cellular clearance systems induces inflammasome signaling in human ARPE-19 cells. BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR CELL RESEARCH 1843 12: 3038-3046. 2014
• Porela-Tiihonen S, Kaarniranta K, Kokki M, Kokki H. 2014. Recovery and patient satisfaction after cataract surgery. A one-year prospective follow-up study. ACTA OPHTHALMOLOGICA 93 2: e172-e173. 2014
• Petrovski G, Pásztor K, Orosz L, Albert R, Mencel E, Moe MC, Kaarniranta K, Facskó A, Megyeri K. 2014. Herpes simplex virus types 1 and 2 modulate autophagy in SIRC corneal cells. Journal of Biosciences 39 4: 683-692. 2014
• Salminen A, Kauppinen A, Kaarniranta K. 2014. Inflammaging Signaling in Health Span and Life Span Regulation: Next Generation Targets for Longevity: Irfan Rahman and Debasis Bagchi, Inflammation, Advancing Age and Nutrition: Research and Clinical Interventions. 323-332. 2014
• Sorkio Anni, Hongisto Heidi, Kaarniranta Kai, Uusitalo Hannu, Juuti-Uusitalo Kati, Skottman Heli. 2014. Structure and barrier properties of human embryonic stem cell-derived retinal pigment epithelial cells are affected by extracellular matrix protein coating. TISSUE ENGINEERING 20 3-4: 622-634. 2014
• Salminen Antero, Kaarniranta Kai, Hiltunen Mikko, Kauppinen Anu. 2014. Krebs cycle dysfunction shapes epigenetic landscape of chromatin: Novel insights into mitochondrial regulation of aging process. CELLULAR SIGNALLING 26: 1598-1603. 2014
• Salminen Antero, Kauppinen Anu, Hiltunen Mikko, Kaarniranta Kai. 2014. Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process. AGEING RESEARCH REVIEWS 16: 45-65. 2014
• Smedowski A, Pietrucha-Dutczak M, Kaarniranta K, Lewin-Kowalik J. 2014. A rat experimental model of glaucoma incorporating rapid-onset elevation of intraocular pressure. Scientific Reports 4: 5910; 1-11. 2014
• Smedowski Adrian, Paterno Jussi J, Toropainen Elisa,Sinha Debasish, Wylegala Edward, Kaarniranta Kai. 2014. Excipients of preservative-free latanoprost induced inflammatory response and cytotoxicity in immortalized human HCE-2 corneal epithelial cells Journal of biochemical and pharmacological research 2 4: 175-184. 2014
• Smedowski Adrian, Weglarz Beata, Tarnawska Dorota, Kaarniranta Kai, Wylegala Edward. 2014. Comparison of three intraocular pressure measurement methods including biomechanical properties of the cornea. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55 2: 666-673. 2014
• Subrizi Astrid, Toropainen Elisa, Ramsay Eva, Airaksinen Anu J, Kaarniranta Kai, Urtti Arto. 2014. Oxidative Stress Protection by Exogenous Delivery of rhHsp70 Chaperone to the Retinal Pigment Epithelium (RPE), a Possible Therapeutic Strategy Against RPE Degeneration. PHARMACEUTICAL RESEARCH 2015; 32: 211-221. 2014
• Pfeiffer N, Traverso CE, Lorenz K, Saarela V, Liinamaa J, Uusitalo H, Astakhov Y, Boiko E, Ropo A, Preservative-free Tafluprost/Timolol Fixed Combination Study Group Collaborators: Uusitalo H, Kaarniranta K,Saarela V, Pfeiffer N, Bartz-Schmidt U, Dunker S, Hamacher T, Heidemann K,Hofmann G, et al.. 2014. A 6-month study comparing efficacy, safety, and tolerability of the preservative-free fixed combination of tafluprost 0.0015% and timolol 0.5% versus each of its individual preservative-free components. Advances in therapy 31 12: 1228-1246. 2014
• Kivinen Niko, Dithmer Michaela, Kinnunen Kati, Lucius Ralph, Roider Johann, Kaarniranta Kai, Klettner Alexa. 2014. Bevacizumab does not affect autophagy clearance during proteasomal inhibition in human retinal pigment epithelial cells. Journal of Biochemical and Pharmacological Research 2 1: 44-53. 2014
• Penttilä E, Hyttinen JMT, Hytti M, Kauppinen A, Smirnov G, Tuomilehto H, Seppä J, Nuutinen J, Kaarniranta K. 2014. Upregulation of inflammatory genes in the nasal mucosa of patients undergoing endonasal dacryocystorhinostomy. Clinical Ophthalmology 8: 799-805. 2014
• Kaarniranta Kai, Machalinska Anna, Veréb Zoltán, Salminen Antero, Petrovski Goran, Kauppinen Anu. 2014. Estrogen Signalling in the Pathogenesis of Age-Related Macular Degeneration. CURRENT EYE RESEARCH 2014: 1-8. 2014
• Oksala Niku KJ, Ekmekci F Güler, Özsoy Ergi, Kirankaya Serife, Kokkola Tarja, Emecen Güzin, Lappalainen Jani, Kaarniranta Kai, Atalay Mustafa. 2014. Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress. Redox Biology 3: 25-28. 2014
• Aaltonen Vesa, Kinnunen Kati, Jouhilahti Eeva-Mari, Peltonen Juha, Nikinmaa Mikko, Kaarniranta Kai, Arjamaa Olli. 2014. Hypoxic conditions stimulate the release of B-type natriuretic peptide from human retinal pigment epithelium cell culture. ACTA OPHTHALMOLOGICA 92 8: 740-744. 2014
• Helisalmi Seppo, Immonen Ilkka, Losonczy Gergely, Resch Miklos D, Benedek Szabolcs, Balogh Istvan, Papp Andras, Berta Andras, Uusitupa Matti, Hiltunen Mikko, Kaarniranta Kai. 2014. ADAMTS9 locus associates with increased risk of wet AMD. ACTA OPHTHALMOLOGICA 2014: 1. 2014
• Hyttinen JM, Amadio M, Viiri J, Pascale A, Salminen A, Kaarniranta K. 2014. Clearance of misfolded and aggregated proteins by aggrephagy and implications for aggregation diseases. AGEING RESEARCH REVIEWS 18: 16-28. 2014
• Blasiak Janusz, Petrovski Goran, Veréb Zoltan, Facskó Andrea, Kaarniranta Kai. 2014. Oxidative stress, hypoxia, and autophagy in the neovascular processes of age-related macular degeneration. BioMed Research International 2014: 1-7. 2014
• Kauppinen Anu, Nevalainen Tapio, Hytti Maria, Salminen Antero, Kaarniranta Kai, Parkkari Teija. 2014. CB2 receptor as a potential target in age-related diseases. Journal of Biochemical and Pharmacological Research 2 1: 33-43. 2014
• Khandelwal VK, Mitrofan LM, Hyttinen JM, Chaudhari KR, Buccione R, Kaarniranta K, Ravingerová T, Mönkkönen J. 2014. Oxidative stress plays an important role in zoledronic acid-induced autophagy. PHYSIOLOGICAL RESEARCH 63 Suppl. 4: S601-S612. 2014
• Kinnunen K, Kaarniranta K. 2014. Silmänpohjan kostea ikärappeuma pitää hoitaa ajoissa. SUOMEN LÄÄKÄRILEHTI 69 37: 2265-2268. 2014
• Kinnunen Kati, Kauppinen Anu, Piippo Niina, Koistinen Arto, Toropainen Elisa, Kaarniranta Kai. 2014. Cationorm shows good tolerability on human HCE-2 corneal epithelial cell cultures. EXPERIMENTAL EYE RESEARCH 120: 82-89. 2014
• Kivinen Niko, Hyttinen Juha MT, Viiri Johanna, Paterno Jussi, Felszheghy Szabolcs, Kauppinen Anu, Salminen Antero, Kaarniranta Kai. 2014. Hsp70 binds reversibly to proteasome inhibitor-induced protein aggregates and evades autophagic clearance in ARPE-19 cells Journal of biochemical and pharmacological research 2 1: 1-7. 2014
• Koskela Ali, Reinisalo Mika, Hyttinen Juha MT, Kaarniranta Kai, Karjalainen Reijo O. 2014. Pinosylvin-mediated protection against oxidative stress in human retinal pigment epithelial cells. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 20: 760-769. 2014
• Porela-Tiihonen S, Kaarniranta K, Kokki M, Purhonen S, Kokki H. 2013. A prospective study on postoperative pain after cataract surgery.. Clinical Ophthalmology 7: 1429-1435. 2013
• Vottonen P, Kaarniranta K, Pääkkönen A, Tarkka IM. 2013. Changes in neurophysiologic markers of visual processing following beneficial anti-VEGF treatment in macular degeneration. Clinical Ophthalmology 7: 437-442. 2013
• Viiri J, Amadio M, Marchesi N, Hyttinen JM, Kivinen N, Sironen R, Rilla K, Akhtar S, Provenzani A, D'Agostino VG, Govoni S, Pascale A, Agostini H, Petrovski G, Salminen A, Kaarniranta K. 2013. Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells. PLOS ONE [ONLINE] 8 7: e6963, 16 pages. 2013
• Tokarz P, Kauppinen A, Kaarniranta K, Blasiak J. 2013. Oxidative DNA Damage and Proteostasis in Age-Related Macular Degeneration. Journal of Biochemical and Pharmacological Research 1 2: 106-113. 2013
• Tokarz P, Kaarniranta K, Blasiak J. 2013. Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD). BIOGERONTOLOGY 14 5: 461-82. 2013
• Salminen A, Kauppinen A, Hiltunen M, Kaarniranta K. 2013. Epigenetic regulation of ASC/TMS1 expression: potential role in apoptosis and inflammasome function. CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS -: -. 2013
• Salminen A, Kaarniranta K, Kauppinen A. 2013. Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 14: 3834-3859. 2013
• Salminen A, Kaarniranta K, Kauppinen A. 2013. Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process. AGEING RESEARCH REVIEWS 12: 520-534. 2013
• Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. 2013. Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome. PROGRESS IN NEUROBIOLOGY 106-107: 33-54. 2013
• Pitkänen L, Tommila P, Kaarniranta K, Jääskeläinen JE, Kinnunen K. 2013. Retinal arterial macroaneurysms. ACTA OPHTHALMOLOGICA 2013: 1-4. 2013
• Porela-Tiihonen S, Kaarniranta K, Kokki H. 2013. Postoperative pain after cataract surgery. JOURNAL OF CATARACT AND REFRACTIVE SURGERY 39 5: 789-98. 2013
• Klettner A, Kauppinen A, Blasiak J, Roider J, Salminen A, Kaarniranta K. 2013. Cellular and molecular mechanisms of age-related macular degeneration: From impaired autophagy to neovascularization. International Journal of Biochemistry & Cell Biology 45: 1457-1467. 2013
• Kauppinen A, Suuronen T, Ojala J, Kaarniranta K, Salminen A. 2013. Antagonistic crosstalk between NF-kappaB and SIRT1 in the regulation of inflammation and metabolic disorders. CELLULAR SIGNALLING 25: 1939-1948. 2013
• Kauppinen A, Salminen A, Kaarniranta K. 2013. Inflammation as a target of minocycline: special interest in the regulation of inflammasome signaling. INFLAMMASOME 1: 2-14. 2013
• Kaarniranta K. 2013. Silmänpohjan kostean ikärappeuman hoito. LÄNSI-SUOMEN TERVEYDENHOITOLEHTI 1: 20. 2013
• Kaarniranta K, Sinha D, Blasiak J, Kauppinen A, Vereb Z, Salminen A, Boulton ME, Petrovski G. 2013. Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. AUTOPHAGY 9 7: 1-12. 2013
• Hyttinen JMT, Niittykoski M, Salminen A, Kaarniranta K. 2013. Maturation of autophagosomes and endosomes: A key role for Rab7. BIOCHIMICA ET BIOPHYSICA ACTA 1833: 503-510. 2013
• Blasiak J, Salminen A, Kaarniranta K. 2013. Potential of epigenetic mechanisms in AMD pathology. FRONTIERS IN BIOSCIENCE 5: 412-425. 2013
• Blasiak J, Glowacki S, Kauppinen A, Kaarniranta K. 2013. Mitochondrial and nuclear DNA damage and repair in age-related macular degeneration. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 14 2: 2996-3010. 2013
• Salminen A, Kauppinen A, Kaarniranta K. 2012. Phytochemicals suppress nuclear factor-kappaB signaling: impact on health span and the aging process CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE 15: 23-28. 2012
• Salminen A, Hyttinen JMT, Kauppinen A, Kaarniranta K. 2012. Context-dependent regulation of autophagy by IKK-NF-kappaB signaling: Impact on the aging process. International Journal of Cell Biology 2012 ID 849541: 15 pages. 2012
• Salminen A, Kaarniranta K. 2012. AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network AGEING RESEARCH REVIEWS 11: 230-241. 2012
• Salminen A, Kauppinen A, Kaarniranta K. 2012. Emerging role of NF-kappaB signaling in the induction of senescence-associated secretory phenotype (SASP) CELLULAR SIGNALLING 24: 835-845. 2012
• Seppä J, Smirnov G, Kaarniranta K, Tuomilehto H. 2012. Aikuisten alakyyneltietukosten kirurginen hoito. DUODECIM 128 2: 205-2011. 2012
• Salminen A, Ojala J, Kaarniranta K, Kauppinen A. 2012. Mitochondrial dysfunction and oxidative stress active inflammasomes: impact on the aging process and age-related diseases CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS 69: 2999-3013. 2012
• Salminen, A; Kaarniranta, K; Haapasalo, A; Hiltunen, M; Soininen, H; Alafuzoff, I. 2012. Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease. PROGRESS IN NEUROBIOLOGY 96: 87-95. 2012
• Salminen, A; Kaarniranta, K; Kauppinen, A. 2012. Inflammaging: disturbed interplay between autophagy and inflammasomes. AGING 4 3: 166-175. 2012
• Petrovski, G; Albert, R; Kaarniranta, K; Morten, CM; Fésus, L; Berta, A; Das, DK. 2012. Autophagy in the eye: a double-edged sword, (Chapter 8): Ed. Gorbunov, Nikolai, Autophagy: Principles, Regulation & Roles in Disease.. 157-180. 2012
• Szalai, E; Felszeghy, S; Hegyi, Z; Módis, L Jr; Berta, A; Kaarniranta, K. 2012. Fibrillin-2, tenascin-C, matrilin-2, and matrilin-4 are strongly expressed in the epithelium of human granular and lattice type I corneal dystrophies. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 18: 1927-1936. 2012
• Pärssinen, O; Hiltunen, H; Kaarniranta, K. 2012. Relation of biometric eye profile with intraocular pressure corrections in healthy myopes. ACTA OPHTHALMOLOGICA 90 5: e410-412. 2012
• Klionsky, DJ, Abdalla, FC; Abeliovich, H; Abraham, RT; Acevedo-Arozena, A; Adeli, K; Agholme, L; Agnello, M; Agostinis, P; Aguirre-Ghiso, JA; Ait-Mohamed, O; Ait-Si-Ali, S; Akematsu, T; Akira, S; Al-Younes, HM; Al-Zeer, MA; Albert, ML; Albin, RL; Alegre-Abarrategui, J; Kaarniranta, K; et al.. 2012. Guidelines for the use and interpretation of assays for monitoring autophagy. AUTOPHAGY 8 4: 445-544. 2012
• Paimela, T; Ryhänen, T; Kauppinen, A; Marttila, L; Salminen, A; Kaarniranta, K. 2012. The preservative polyquaternium-1 increases cytoxicity and NF-kappaB linked inflammation in human corneal epithelial cells MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 18: 1189-1196. 2012
• Kaarniranta, K. 2012. Silmänpohjan ikärappeuma yleistyy. OPTOMETRIA 3: 39-41. 2012
• Blasiak, J; Synowiec, E; Salminen, A; Kaarniranta, K. 2012. Genetic Variability in DNA Repair Proteins in Age-Related Macular Degeneration. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 13 10: 13378-13379. 2012
• Kaarniranta K, Kauppinen A, Blasiak J, Salminen A. 2012. Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration. Future Medicinal Chemistry 4 17: 2153-2161. 2012
• Kaarniranta K, Paananen J, Nevalainen T, Sorri I, Seitsonen S, Immonen I, Salminen A, Pulkkinen L, Uusitupa M. 2012. Adiponectin receptor 1 gene (ADIPOR1) variant is associated with advanced age-related macular degeneration in Finnish population. NEUROSCIENCE LETTERS 513 2: 233-237. 2012
• Juuti-Uusitalo, K; Vaajasaari, H; Ryhänen, T; Narkilahti, S; Suuronen, R; Mannermaa, E; Kaarniranta, K; Skottman, H. 2012. Efflux Protein Expression in Human Stem Cell-Derived Retinal Pigment Epithelial Cells PLOS ONE [ONLINE] 7 1: 1-10. 2012
• Kauppinen A, Niskanen H, Suuronen T, Kinnunen K, Salminen A, Kaarniranta K. 2012. Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells - Implications for age-related macular degeneration (AMD) IMMUNOLOGY LETTERS 147: 29-33. 2012
• Kinnunen, K; Petrovski, G; Moe, MC; Berta, A; Kaarniranta, K. 2012. Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration ACTA OPHTHALMOLOGICA 90 4: 299-309. 2012
• Kinnunen, PK; Kaarniranta, K; Mahalka, AK. 2012. Protein-oxidized phospholipid interactions in cellular signaling for cell death: From biophysics to clinical correlations BIOCHIMICA ET BIOPHYSICA ACTA - BIOMEMBRANES 1818 10: 2446-2455. 2012
• Mika Reinisalo, Tuomas Paimela, Tuomas Ryhänen, Anu Kauppinen, Ali Koskela, Tuula Soininen, Kai Kaarniranta, Reijo Karjalainen. 2012. Protective function of wood-derived stilbenes against oxidative stress and inflammation in ARPE-19 cells. In: (ed.) , XXVIth International Conference on Polyphenols, Polyphenols Communications 2012. ss. 501-502. 2012
• Mykkänen OT, Kalesnykas G, Adriaens M, Evelo CT, Törrönen R, Kaarniranta K. 2012. Bilberries potentially alleviate stress-related retinal gene expression induced by a high-fat diet in mice MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 18: 2338-2351. 2012
• Salminen A, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H, Alafuzoff I. 2011. Emerging role of p62/sequestosome-1 in th pathogenesis of Alzheimer's disease PROGRESS IN NEUROBIOLOGY 96: 87-95. 2011
• Smirnov G, Pirinen R, Tuomilehto H, Seppä J, Teräsvirta M, Uusitalo H, Nuutinen J, Kaarniranta K. 2011. Strong expression of HSP47 in metaplastic nasal mucosa may predict a poor outcome after primary endoscopic dacryocystorhinostomy: a prospective study ACTA OPHTHALMOLOGICA 89 2: e132-e136. 2011
• Seppo Rönkkö, Kai Kaarniranta, Giedrius Kalesnykas, Hannu Uusitalo. 2011. Biocompatibility of different poly(lactide-coglycolide) polymers implanted into the subconjunctival space in rats OPHTHALMIC RESEARCH 46: 55-65. 2011
• Saviranta Niina, Veeroos Laura, Granlund Lars, Hassinen Viivi, Kaarniranta Kai, Karjalainen Reijo. 2011. Plant flavonol quercetin and isoflavone biochanin-A differentially induce protection against oxidative stress and inflammation in ARPE-cells FOOD RESEARCH INTERNATIONAL 44: 109-113. 2011
• Salminen Antero, Kaarniranta Kai. 2011. Control of p53 and NF-kB signaling by WIP1 and MIF: Role in cellular senescence and organismal aging. CELLULAR SIGNALLING 23: 747-752. 2011
• Salminen A, Ojala J, Kaarniranta K. 2011. Apoptosis and aging: increased resistance to apoptosis enhances the aging process CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS 68: 1021-1031. 2011
• Salminen A, Ojala J, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H. 2011. Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 34: 3-11. 2011
• Salminen A, Kaarniranta K, Haapasalo A, Soininen H, Hiltunen M. 2011. AMP-activated protein kinase: a potential player in Alzheimer's disease JOURNAL OF NEUROCHEMISTRY 118: 460-474. 2011
• Penttilä E, Smirnov G, Seppä J, Kaarniranta K, Tuomilehto H. 2011. Mitomycin C in revision endoscopic dacryocystorhinostomy: A prospective randomized study American Journal of Rhinology & Allergy 25 6: 425-428. 2011
• Salminen A, Hyttinen JMT, Kaarniranta K. 2011. AMP-activated protein kinase inhibits NF-kappaB signaling and inflammation: impact on healthspan and lifespan. JOURNAL OF MOLECULAR MEDICINE 89: 667-676. 2011
• Paimela T, Hyttinen JMT, Viiri J, Ryhänen T, Karjalainen RO, Salminen A, Kaarniranta K. 2011. Celastrol regulates innate immunity response via NF-kappaB and Hsp70 in human retinal pigment epithelial cells. PHARMACOLOGICAL RESEARCH 64: 501-508. 2011
• Nevalainen T, Kaarniranta K, Puustjärvi T, Kontkanen M. 2011. Ravistellun lapsen oireyhtymään liittyvät silmälöydökset SUOMEN LÄÄKÄRILEHTI 66 6: 453-455. 2011
• Kaarniranta K. 2011. Silmänpohjan ikärappeuman hoidossa halvempi on tehokas ja turvallinen SUOMEN LÄÄKÄRILEHTI 22: 1812. 2011
• Kaarniranta K, Salminen A, Haapasalo A, Soininen H, Hiltunen M. 2011. Age-related macular degeneration (AMD): Alzheimer's Disease in the eye Journal of Alzheimer's Disease 24: 615-631. 2011
• Jauhonen H-M, Kauppinen A, Paimela T, Laihia JK, Leino L, Salminen A, Kaarniranta K. 2011. Cis-urocanic acid inhibits SAPK/JNK signaling pathway in UV-B exposed human corneal epithelial cells in vitro. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 17: 2311-2317. 2011
• Hyttinen JM, Petrovski G, Salminen A, Kaarniranta K. 2011. 5'-adenosine monophosphate-activated protein kinase-Mammalian target of rapamycin axis as therapeutic target for age-related macular degeneration REJUVENATION RESEARCH 14 6: 651-660. 2011
• Arjamaa O, Pöllönen M, Kinnunen K, Ryhänen T, Kaarniranta K. 2011. Increased IL-6 levels are not related to NF-kappaB or HIF-1alfa; transcription factors activity in the vitreous of proliferative diabetic retinopathy JOURNAL OF DIABETES AND ITS COMPLICATIONS 25 6: 393-397. 2011
• Viiri J, Hyttinen JMT, Ryhänen T, Rilla K, Paimela T, Kuusisto E, Siitonen A, Urtti A, Salminen A & Kaarniranta K. 2010. p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 16: 1399-1414. 2010
• Uusitalo H, Chen E, Pfeiffer N, Brignole-Baudouin F, Kaarniranta K, Leino M, Puska P, Palmgren E, Hamacher T, Hofmann G, Petzold G, Richter U, Riedel T, Winter M & Ropo A. 2010. Switching from a preserved toa preservative-free prostaglandin preparation in topical glaucoma medication. ACTA OPHTHALMOLOGICA 88: 329-336. 2010
• Smirnov G, Tuomilehto H, Kokki H, Kemppainen T, Kiviniemi V, Nuutinen J, Kaarniranta K & Seppä J. 2010. Symptom score questionnaire for nasolacrimal duct obstruction in adults - a novel tool to assess the outcome after endoscopic dacryocystorhinostomy RHINOLOGY 48: 446-451. 2010
• Salminen A, Ojala J, Kaarniranta K, Hiltunen M & Soininen H. 2010. Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease. PROGRESS IN NEUROBIOLOGY 93: 99-110. 2010
• Salminen A, Lehtonen M, Paimela T & Kaarniranta K. 2010. Celastrol: Molecular targets of Thunder God Vine. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 394: 439 - 442. 2010
• Salminen A, Kauppinen A, Hyttinen JMT, Toropainen E & Kaarniranta K. 2010. Endoplasmic reticulum stress in age-related macular degeneration: Trigger for neovascularization MOLECULAR MEDICINE TODAY 16 11-12: 535-542. 2010
• Salminen A & Kaarniranta K. 2010. Insulin/IGF-1 paradox of aging: Regulation via AKT/IKK/NF-kB signaling. CELLULAR SIGNALLING 22: 573-577. 2010
• Salminen A & Kaarniranta K. 2010. Glycolysis Links p53 Function With NF-kB Signaling: Impact on Cancer and Aging Process. JOURNAL OF CELLULAR PHYSIOLOGY 224: 1-6. 2010
• Salminen A & Kaarniranta K. 2010. Genetics vs. entrophy: Longevity factors suppress the NF-kB-driven entropic aging process. AGEING RESEARCH REVIEWS 9: 298-314. 2010
• Salminen A & Kaarniranta K. 2010. ER stress and hormetic regulation of the aging process AGEING RESEARCH REVIEWS 9: 211-217. 2010
• Paimela T, Hyttinen JMT, Viiri J, Ryhänen T, Karvonen MK, Unkila M, Uusitalo H, Salminen A & Kaarniranta K. 2010. Influence of selective estrogen receptor modulators on interleukin-6 expression in human retinal pigment epithelial cells (ARPE-19). EUROPEAN JOURNAL OF PHARMACOLOGY 640: 219-225. 2010
• Niittykoski M, Kalesnykas G, Larsson KP, Kaarniranta K, Åkerman KEO, Uusitalo H. 2010. Altered calcium signaling in a experimental model of glaucoma. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 51 12: 6387-6393. 2010
• Mannermaa E, Reinisalo M, Ranta V-P, Vellonen K-S, Kokki H, Saarikko A, Kaarniranta K & Urtti A. 2010. Filter-cultured ARPE-19 cells as outer blood-retinal barrier model. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 40: 289-296. 2010
• Kai Kaarniranta, Juha Hyttinen, Tuomas Ryhanen, Johanna Viiri, Tuomas Paimela, Elisa Toropainen, Iiris Sorri & Antero Salminen. 2010. Mechanisms of protein aggregation in the retinal pigment epithelial cells FRONTIERS IN BIOSCIENCE E2: 1374-1384. 2010
• Kaarniranta K. 2010. Regression of necrotizing scleritis in Wegener's granulomatosis after infiximab treatment ACTA OPHTHALMOLOGICA 88 3: e96-97. 2010
• Kaarniranta K. 2010. Autophagy - hot topic in AMD. ACTA OPHTHALMOLOGICA 88: 387-388. 2010
• Ryhänen T, Viiri J, Hyttinen JTM, Uusitalo H, Salminen A & Kaarniranta K. 2010. Influence of Hsp90 and HDAC Inhibition and Tubulin Acetylation on Perinuclear Protein Aggregation in Human Retinal Pigment Epithelial Cells Journal of biomedicine and biotechnology 2011;2011;798052. Epub 2010 Oct 24: 1-8. 2010
• Salminen A, Kaarniranta K. 2009. Regulation of the aging process by autophagy. TRENDS IN MOLECULAR MEDICINE 15 5: 217-224. 2009
• Viiri J, Jauhonen HM, Kauppinen A, Ryhänen T, Paimela T, Hyttinen J, Sorri I, Laihia JK, Leino L, Kaarniranta K. 2009. Cis-urocanic acid suppresses UV-B-induced interleukin-6 and -8 secretion and cytotoxicity in human corneal and conjunctival epithelial cells in vitro MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 15: 1799-1805. 2009
• Tolppanen A-M, Nevalainen T, Kolehmainen M, Seitsonen S, Immonen I, Uusitupa M, Kaarniranta K, Pulkkinen L, Tolppanen A-M, Kolehmainen M, Uusitupa M, Pulkkinen L. 2009. Single nucleotide polymorphisms of the tenomodulin gene (TNMD) in age-related macular degeneration MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 15: 762-770. 2009
• Salminen A, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. 2009. Inflammation in Alzheimer's disease: Amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors PROGRESS IN NEUROBIOLOGY 87: 181-194. 2009
• Salminen A, Kauppinen A, Suuronen T, Kaarniranta K, Ojala J. 2009. ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 6 41: [13 p.]. 2009
• Salminen A, Kaarniranta K. 2009. SIRT1: Regulation of longevity via autophagy CELLULAR SIGNALLING 21: 1356-1360. 2009
• Salminen A, Kaarniranta K. 2009. SIRT1 regulates the ribosomal DNA locus: Epigenetic candles twinkle longevity in the Christmas tree. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 378: 6-9. 2009
• Salminen A, Kaarniranta K. 2009. Siglec receptors and hiding plaques in Alzheimer's disease. JOURNAL OF MOLECULAR MEDICINE 87: 697-701. 2009
• Mannermaa E, Vellonen K-S, Ryhänen T, Kokkonen K, Ranta V-P, Kaarniranta K, Urtti A. 2009. Efflux protein expression in human retinal pigment epithelium cell lines. PHARMACEUTICAL RESEARCH 26 7: 1785-1791. 2009
• Salminen A, Kaarniranta K. 2009. NF-kappaB signaling in the aging process. JOURNAL OF CLINICAL IMMUNOLOGY 29: 397-405. 2009
• Kontkanen M, Kaarniranta K. 2009. Retinal haemorrhages in shaken baby syndrome. ACTA OPHTHALMOLOGICA 87 4: 471-473. 2009
• Kaarniranta K. 2009. Vääristyvä kuva silmänpohjan ikärappeumassa - kuinka hoidetaan? SUOMEN LÄÄKÄRILEHTI 64 44: 3759-3763. 2009
• Kaarniranta K, Seitsonen S, Paimela T, Meri S, Immonen I. 2009. Silmänpohjan ikärappeuman patogeneesi. DUODECIM 125: 145-153. 2009
• Kaarniranta K, Salminen A. 2009. NF-kappaB signaling as a putative target for omega-3 metabolites in the prevention of age-related macular degeneration (AMD). EXPERIMENTAL GERONTOLOGY 44: 685-688. 2009
• Kaarniranta K, Salminen A. 2009. Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors. JOURNAL OF MOLECULAR MEDICINE 87: 117-123. 2009
• Kaarniranta K, Salminen A, Eskelinen E-L, Kopitz J. 2009. Heat shock proteins as gatekeepers of proteolytic pathways - Implications for age-related macular generation (AMD). AGEING RESEARCH REVIEWS 8: 128-139. 2009
• Kaarniranta K, Puustjärvi T, Sorri I. 2009. Silmänpohjan ikärappeuman riskitekijät ja hoito. TERVEYDENHOITOVIESTI, KESKI-SUOMI PIRKANMAA 1: s. 16, 29. 2009
• Arjamaa O, Nikinmaa M, Salminen A, Kaarniranta K. 2009. Regulatory role of HIF-1alfa in the pathogenesis of age-related macular degeneration (AMD). AGEING RESEARCH REVIEWS 8: 349-358. 2009
• Salminen A, Ojala J, Suuronen T, Kaarniranta K, Kauppinen A. 2008. Amyloid-beta oligomers set fire to inflammasomes and induce Alzherimer's pathology. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 12 6A: 2255-2262. 2008
• Uusitalo H, Kaarniranta K, Ropo A. 2008. Pharmacokinetics, efficacy and safety profiles of preserved and preservative-free tafluprost in healthy volunteers. ACTA OPHTHALMOLOGICA. SUPPLEMENT 86 S242: 7-13. 2008
• Seitsonen SP, Onkamo P, Peng G, Xiong M, Tommila PV, Ranta PH, Holopainen JM, Moilanen JA, Palosaari T, Kaarniranta K, Meri S, Immonen IR, Järvelä IE. 2008. Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration. PLOS ONE [ONLINE] 3 12: e3833. 2008
• Salminen A, Suuronen T, Kaarniranta K. 2008. ROCK, PAK, and Toll of synapses in Alzheimer's disease. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 371: 587-590. 2008
• Salminen A, Suuronen T, Huuskonen J, Kaarniranta K. 2008. NEMO shuttle: a link between DNA damage and NF-kappaB activation in progeroid syndromes?. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 367: 715-718. 2008
• Salminen A, Paimela T, Suuronen T, Kaarniranta K. 2008. Innate immunity meets with cellular stress at the IKK complex: Regulation of the IKK complex by HSP70 and HSP90. IMMUNOLOGY LETTERS 117: 9-15. 2008
• Suuronen T, Ojala J, Hyttinen JMT, Kaarniranta K, Thornell A, Kyrylenko S, Salminen A. 2008. Regulation of ERalfa signaling pathway in neuronal HN10 cells: role of protein acetylation and Hsp90. NEUROCHEMICAL RESEARCH 33: 1768-1775. 2008
• Salminen A, Ojala J, Huuskonen J, Kauppinen A, Suuronen T, Kaarniranta K. 2008. Interaction of aging-associated signaling cascades: Inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1. CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS 65: 1049-1058. 2008
• Ryhänen T, Mannermaa E, Oksala N, Viiri J, Paimela T, Salminen A, Atalay M, Kaarniranta K. 2008. Radicicol but not geldanamycin evokes oxidative stress response and efflux protein inhibition in ARPE-19 human retinal pigment epithelial cells. EUROPEAN JOURNAL OF PHARMACOLOGY 584: 229-236. 2008
• Huhtala A, Pohjonen T, Salminen L, Salminen A, Kaarniranta K, Uusitalo H. 2008. In vitro biocompatibility of degradable biopolymers in cell line cultures from various ocular tissues: extraction studies. JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE 19: 645-649. 2008
• Kaarniranta K, Sorri I. 2008. Diabeteksen aiheuttamat silmämuutokset. SUOMEN LÄÄKÄRILEHTI 63 7: 621-624. 2008
• Salminen A, Lehtonen M, Suuronen T, Kaarniranta K, Huuskonen J. 2008. Terpenoids: natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential. CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS 65: 2979-2999. 2008
• Rönkkö S, Rekonen P, Sihvola R, Kaarniranta K, Puustjärvi T, Teräsvirta M, Uusitalo H. 2008. Histopathology of the three implanted degradable biopolymers in rabbit eye. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART A 88 3: 717-724. 2008
• Salminen A, Huuskonen J, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. 2008. Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging. AGEING RESEARCH REVIEWS 7: 83-105. 2008
• Salminen A, Kauppinen A, Suuronen T, Kaarniranta K. 2008. SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation?. BIOESSAYS 30: 939-942. 2008
• Toropainen E, Hornof M, Kaarniranta K, Johansson P, Urtti A. 2007. Corneal epithelium as a platform for secretion of transgene products after transfection with liposomal gene eyedrops. JOURNAL OF GENE MEDICINE 9: 208-216. 2007
• Suuronen T, Nuutinen T, Ryhänen T, Kaarniranta K, Salminen A. 2007. Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 357: 397-401. 2007
• Rönkkö S, Rekonen P, Kaarniranta K, Puustjärvi T, Teräsvirta M, Uusitalo M. 2007. Matrix metalloproteinases and their inhibitors in the chamber angle of normal eyes and patients with primary open-angle glaucoma and exfoliation glaucoma. GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 245: 697-704. 2007
• Rönkkö S, Rekonen P, Kaarniranta K, Puustjärvi T, Teräsvirta M, Uusitalo H. 2007. Phospholipase A2 in chamber angle of normal eyes and patients with primary open angle glaucoma and exfoliation glaucoma. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 13: 408-417. 2007
• Paimela T, Ryhänen T, Mannermaa E, Ojala J, Kalesnykas G, Salminen A, Kaarniranta K, Ojala J. 2007. The effect of 17beta-estradiol on IL-6 secretion and NF-kappaB DNA-binding activity in human retinal pigment epithelial cells. IMMUNOLOGY LETTERS 110: 139-144. 2007
• Oksala NKJ, Lappalainen J, Laaksonen DE, Khanna S, Kaarniranta K, Sen CK, Atalay M. 2007. Alpha-lipoic acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney ANTIOXIDANTS AND REDOX SIGNALING 9 4: 497-506. 2007
• Mannermaa E, Urtti A, Kaarniranta K. 2007. Silmänpohjan nesteisen ikärappeuman uudet lääkkeet. DUODECIM 123: 2229-2237. 2007
• Kalesnykas G, Niittykoski M, Rantala J, Miettinen R, Salminen A, Kaarniranta K, Uusitalo H. 2007. The expression of heat shock protein 27 in retinal ganglion and glial cells in a rat glaucoma model NEUROSCIENCE 150: 692-704. 2007
• Kaarniranta K, Tuppurainen K, Nikolajev K. 2007. Maculopathy in Pierre Robin sequences. JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS 44 1: 10-11. 2007
• Kaarniranta K, Holopainen JM , Karvonen MK, Koulu M, Kallio J, Pesonen U, Teräsvirta M, Uusitalo H, Immonen I. 2007. Leucine 7-proline 7 polymorphism in the signal peptide of neuropeptide Y is not a risk factor for exudative age-related macular degeneration. ACTA OPHTHALMOLOGICA 85: 188-191. 2007
• Huhtala A, Pohjonen T, Salminen L, Salminen A, Kaarniranta K, Uusitalo H. 2007. In vitro biocompatibility of degradable biopolymers in cell line cultures from various ocular tissues:Direct contact studies. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART A 83A 2: 407-413. 2007
• Leppälä J, Kaarniranta K, Uusitalo H, Kontkanen M. 2007. Imiquimod in the treatment of eyelid basal cell carcinoma. ACTA OPHTHALMOLOGICA 85: 566-568. 2007
• Kaarniranta K, Ihanamäki T, Sahlman J, Pulkkinen H, Uusitalo H, Arita M, Tammi R, Lammi MJ, Helminen H. 2006. A mouse model for Stickler's syndrome: Ocular phenotype of mice carrying a targeted heterozygous inactivation of type II (pro)collagen gene (Col2al) EXPERIMENTAL EYE RESEARCH 83: 297-303. 2006
• Määttä M, Tervahartiala T, Kaarniranta K, Tang Y, Yan L, Tuukkanen J, Sorsa T. 2006. Immunolocalization of EMMPRIN (Cd147) in the human eye and detection of soluble form of EMMPRIN in ocular fluids. CURRENT EYE RESEARCH 31 11: 917-924. 2006
• Seitsonen S, Lemmelä S, Holopainen J, Tommila P, Ranta P, Kotamies A, Moilanen J, Palosaari T, Kaarniranta K, Meri S, Immonen I, Järvelä I. 2006. Analysis of variants in the complement factor H, the elongation of very long chain fatty acids-like 4 and the hemicentin 1 genes of age-related macular degeneration in the Finnish population. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 12: 796-801. 2006
• Kaarniranta K. 2005. Solustressi yhdistyy silmänpohjan ikärappeumaan. SILMÄHOITAJA 2: 4-5. 2005
• Elo MA, Kaarniranta K, Helminen HJ, Lammi MJ. 2005. Hsp90 inhibitor geldanamycin increases hsp70 mRNA stabilisation but fails to activate HSF1 in cells exposed to hydrostatic pressure BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR CELL RESEARCH 1743 1-2: 115-119. 2005
• Kaarniranta K, Ryhänen T, Sironen RK, Suuronen T, Elo MA, Karjalainen HM, Lammi MJ, Teräsvirta M, Uusitalo H, Salminen A. 2005. Geldanamycin activates Hsp70 response and attenuates okadaic acid-induced cytotoxicity in human retinal pigment epithelial cells MOLECULAR BRAIN RESEARCH 137: 126-131. 2005
• Kaarniranta K, Ryhänen T, Karjalainen HM, Lammi MJ, Suuronen T, Huhtala A, Kontkanen M, Teräsvirta M, Uusitalo H, Salminen A. 2005. Geldanamycin increases 4-hydroxynonenal (HNE)-induced cell death in human retinal pigment epithelial cells. NEUROSCIENCE LETTERS 382: 185-190. 2005
• Lammi MJ, Elo MA, Sironen RK, Karjalainen HM, Kaarniranta K, Helminen HJ. 2004. Hydrostatic pressure-induced changes in cellular protein syntheisis BIORHEOLOGY 41: 309-313. 2004
• Elo MA, Sironen RK, Karjalainen HM, Kaarniranta K, Helminen HJ, Lammi MJ. 2003. Specific induction of heat shock protein 90 beta by high hydrostatic pressure BIORHEOLOGY 40 1-3: 141-146. 2003
• Kaarniranta K, Elo MA, Sironen RK, Karjalainen HM, Helminen HJ, Lammi MJ. 2003. Stress responses of mammalian cells to high hydrostatic pressure. BIORHEOLOGY 40 1-3: 87-92. 2003
• Kaarniranta K, Sihvola R, Salminen A, Lammi MJ, Teräsvirta M, Kontkanen M. 2003. Silmänpohjan ikärappeuma - vaikea ongelma sekä potilaalle että silmälääkärille. DUODECIM 119: 935-942. 2003
• Karjalainen HM, Sironen RK, Elo MA, Kaarniranta K, Takigawa M, Helminen HJ, Lammi MJ. 2003. Gene expression profiles in chondrosarcoma cells subjected to cyclic stretching and hydrostatic pressure. A cDNA array study BIORHEOLOGY 40 1-3: 93-100. 2003
• Törrönen K, Yabal M, Rilla K, Kaarniranta K, Tammi R, Lammi MJ, Tammi M. 2002. Hyaluronan stimulates keratinocyte migration and activates the transcription factor AP-1 in keratinocytes through the JNK pathway. In: Kennedy JF, Phillips GO, Williams PA, Hascall VC (ed.) , Hyaluronan. Chemical, Biochemical and Biological Aspects..Woodhead. ss. 551-556. 2002
• Sironen RK, Karjalainen HM, Törrönen K, Elo MA, Kaarniranta K, Takigawa M, Helminen HJ, Lammi MJ. 2002. High pressure effects on cellular expression profile and mRNA stability. A cDNA array analysis. BIORHEOLOGY 39 1,2: 111-117. 2002
• Sironen RK, Karjalainen HM, Elo MA, Kaarniranta K, Törrönen K, Takigawa M, Helminen HJ, Lammi MJ. 2002. cDNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure. BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR CELL RESEARCH 1591: 45-54. 2002
• Kaarniranta K. 2002. Regulatory Differences of the hsp70 Gene Response in Mammalian Cells. Kuopion yliopiston julkaisuja D. Lääketiede. 2002
• Kaarniranta K, Oksala N, Karjalainen HM, Suuronen T, Sistonen L, Helminen HJ, Salminen A, Lammi MJ. 2002. Neuronal cells show regulatory differences in the hsp70 gene response MOLECULAR BRAIN RESEARCH 101: 136-140. 2002
• Kaarniranta K, Holmberg CI, Lammi MJ, Eriksson JE, Sistonen L, Helminen HJ. 2001. Primary chondrocytes resist hydrostatic pressure-induced stress while primary synovial cells and fibroblasts show modified Hsp70 response OSTEOARTHRITIS AND CARTILAGE 9 1: 7-13. 2001
• Kaarniranta K, Oksala N, Lammi MJ, Helminen HJ, Sistonen L. 2001. Solustressin tutkimuksesta kliinisiin läpimurtoihin?. DUODECIM 117: 2266-2272. 2001
• Lammi MJ, Sironen RK, Elo MA, Oksala N, Kaarniranta K, Karjalainen HM, Helminen HJ. 2001. Responses of mammalian cells to mechanical forces: Pandalai SG, Recent Research Developments in Biophysics and Biochemistry.Research Signpost. 77-98. 2001
• Elo MA, Sironen RK, Kaarniranta K, Auriola S, Helminen HJ, Lammi MJ. 2000. Differential regulation of stress proteins by high hydrostatic pressure, heat shock, and unbalanced calcium homeostasis in chondrocytis cells. JOURNAL OF CELLULAR BIOCHEMISTRY 79: 610-619. 2000
• Kaarniranta K, Holmberg CI, Helminen HJ, Eriksson JE, Sistonen L, Lammi MJ. 2000. Protein synthesis is required for stabilization of hsp70 mRNA upon exposure to both hydrostatic pressurization and elevated temperature. FEBS LETTERS 475: 283-286. 2000
• Sironen R, Elo M, Kaarniranta K, Helminen HJ, Lammi MJ. 2000. Transcriptional activation in chondrocytes submitted to hydrostatic pressure BIORHEOLOGY 37: 85-93. 2000
• Parkkinen JJ, Lammi MJ, Jortikka MO, Inkinen RI, Kaarniranta K, Helminen HJ, Tammi MI. 1999. Cytoskeleton and proteoglycan synthesis in chondrocytes under hydrostatic pressure: Tanaka S, Hamanishi C, Advances in Osteoarthritis.Springer. 21-34. 1999
• Alastalo T-P, Lönnström M, Leppä S, Kaarniranta K, Pelto-Huikko M, Sistonen L, Parvinen M. 1998. Stage-specific expression and cellular localization of the heat shock factor 2 isoforms in the rat seminiferous epithelium. EXPERIMENTAL CELL RESEARCH 240: 16-27. 1998
• Kaarniranta K, Elo M, Sironen R, Lammi MJ, Goldring MB, Eriksson JE, Sistonen L, Helminen HJ. 1998. Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 95: 2319-2324. 1998

Research groups

• Kaarniranta AMD Lab