Kaisa Paldanius

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Coordinator, Brain Research Unit. Responsibilities include coordination of Brain Research Unit activities in EU-funded research projects related to aging and dementia risk reduction, e.g. AD-RIDDLE, PROMINENT and 2D-BioPAD (Horizon, IHI)

Information Publications

Keywords

Aging Research Alzheimer's disease biomarker research clinical drug research clinical drug trials dementia prevention lifestyle factors memory disorders

Publications

24/24 items

Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aß
Marttinen, Mikael; Ferreira, Catarina B; Paldanius, Kaisa M A; Takalo, Mari; Natunen, Teemu; Mäkinen, Petra; Leppänen, Luukas; Leinonen, Ville; Tanigaki, Kenji; Kang, Gina; Hiroi, Noboru; Soininen, Hilkka; Rilla, Kirsi; Haapasalo, Annakaisa; Hiltunen, Mikko. 2020. Cells. 9: 2482
Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury
Das Gupta, S; Lipponen, A; Paldanius, KMA; Puhakka, N; Pitkänen, A. 2019. Scientific reports. 9: 20208
Using online game-based platforms to improve student performance and engagement in histology teaching
Felszeghy, S; Pasonen-Seppänen, S; Koskela, A; Nieminen, P; Härkönen, K; Paldanius, KMA; Gabbouj, S; Ketola, K; Hiltunen, M; Lundin, M; Haapaniemi, T; Sointu, E; Bauman, EB; Gilbert, GE; Morton, D; Mahonen, A. 2019. Bmc medical education. 19: 273
A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology
Marttinen, M; Paananen, J; Neme, A; Mitra, V; Takalo, M; Natunen, T; Paldanius, KMA; Mäkinen, P; Bremang, M; Kurki, MI; Rauramaa, T; Leinonen, V; Soininen, H; Haapasalo, A; Pike, I; Hiltunen, M. 2018. Neurobiology of disease. 2019; 124: 454-468
Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice
Gabbouj, S; Natunen, T; Koivisto, H; Jokivarsi, K; Takalo, M; Marttinen, M; Wittrahm, R; Kemppainen, S; Naderi, R; Posado-Fernández, A; Ryhänen, S; Mäkinen, P; Paldanius, KMA; Doria, G; Poutiainen, P; Flores, O; Haapasalo, A; Tanila, H; Hiltunen, M. 2018. Neurobiology of aging. 2019; 75: 98-108
Protein kinase C -activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations
Sarajärvi, T; Jäntti, M; Paldanius, KMA; Natunen, T; Wu, JC; Mäkinen, P; Tarvainen, I; Tuominen, RK; Talman, V; Hiltunen, M. 2018. Neuropharmacology. 141: 76-88
Behavioral testing of mice exposed to intermediate frequency magnetic fields indicates mild memory impairment
Kumari K, Koivisto H, Viluksela M, Paldanius KMA, Marttinen M, Hiltunen M, Naarala J, Tanila H, Juutilainen J. 2017. PLoS ONE. 12: e0188880
DHCR24 exerts neuroprotection upon inflammation-induced neuronal death
Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M. 2017. Journal of neuroinflammation. : 215
New Implications for the Role for Ubiquilin-1 in Molecular Mechanisms of Alzheimer's Disease: Interrelationship with BACE1
Takalo Mari, Natunen Teemu, Leskelä Stina, Paldanius Kaisa MA, Soininen Hilkka, Hiltunen MIkko, Haapasalo Annakaisa. 2017. Journal of Alzheimer's disease & Parkinsonism. 7: 365
Effects of Alzheimer's Disease-Associated Risk Loci on Cerebrospinal Fluid Biomarkers and Disease Progression: A Polygenic Risk Score Approach
Martiskainen Henna, Helisalmi Seppo, Viswanathan Jayashree, Kurki Mitja, Hall Anette, Herukka Sanna-Kaisa, Sarajärvi Timo, Natunen Teemu, Kurkinen Kaisa M.A., Huovinen Jaakko, Mäkinen Petra, Laitinen Marjo, Koivisto Anne M., Mattila Kari M., Lehtimäki Terho, Remes Anne M., Leinonen Ville, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2015. Journal of Alzheimer's disease. 43: 565-573
Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models
Natunen Teemu, Takalo Mari, Kemppainen Ssusanna, Leskelä Stina, Marttinen Mikael, Kurkinen Kaisa MA, Pursiheimo Juha-Pekka, Sarajärvi Timo, Viswanathan Jayashree, Gabbouj Sami, Solje Eino, Tahvanainen Eveliina, Pirttimäki Tiina, Kurki Mitja, Paananen Jussi, Rauramaa Tuomas, Miettinen Pasi, Mäkinen Petra, Leinonen Ville, Soininen Hilkka et al. 2015. Neurobiology of disease. 2016; 85: 187-205
Synaptic dysfunction and septin protein family members in neurodegenerative diseases
Marttinen Mikael, Kurkinen Kaisa MA, Soininen Hilkka, Haapasalo Annakaisa, Hiltunen Mikko. 2015. Molecular neurodegeneration. 10: 12 p
High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status
Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. 2014. Journal of nutritional biochemistry. 25: 634-641
Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models
Martiskainen H, Viswanathan J, Nykänen NP, Kurki M, Helisalmi S, Natunen T, Sarajärvi T, Kurkinen KM, Pursiheimo JP, Rauramaa T, Alafuzoff I, Jääskeläinen JE, Leinonen V, Soininen H, Haapasalo A, Huttunen HJ, Hiltunen M. 2014. Neurobiology of aging. 36: 1221.e15-1221.e28
Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's Disease
Natunen T, Parrado AR, Helisalmi S, Pursiheimo J-P, Sarajärvi T, Mäkinen P, Kurkinen KMA, Mullin K, Alafuzoff I, Haapasalo A, Bertram L, Soininen H, Tanzi RE, Hiltunen M. 2013. Journal of Alzheimer's disease. 37: 217-232
Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease
Martiskainen H, Haapasalo A, Kurkinen KM, Pihlajamäki J, Soininen H, Hiltunen M. 2013. Expert opinion on therapeutic targets. 17: 781-794
Targeting ubiquilin-1 in Alzheimer's disease
Takalo M, Haapasalo A, Natunen T, Viswanathan J, Kurkinen KMA, Tanzi RE, Soininen H, Hiltunen M. 2013. Expert opinion on therapeutic targets. 17: 795-810
Ubiquilin-1 modulates gamma-secretase-mediated epsilon-site cleavage in neuronal cells
Viswanathan J, Haapasalo A, Kurkinen KMA, Natunen T, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Hiltunen M. 2013. Biochemistry. 52: 3899-3912
Alzheimer's disese-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation
Viswanathan Jayashree, Haapasalo Annakaisa, Böttcher Claudia, Miettinen Riitta, Kurkinen Kaisa MA, Lu Alice, Thomas Anne, Maynard Christa J, Romano Donna, Hyman Bradley T, Berezovska Oksana, Bertram Lars, Soininen Hilkka, Dantuma Nico P, Tanzi RE, Hiltunen Mikko. 2011. Traffic. 12: 330-348
Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation
Haapasalo A, Viswanathan J, Kurkinen KMA, Bertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M. 2011. Communicative & integrative biology. 4: 428-432
Prevention of NMDA-induced death of cortical neurons by inhibition of protein kinase Czeta
Koponen S, Kurkinen K, Åkerman KEO, Mochly-Rosen D, Chan PH, Koistinaho J. 2003. Journal of neurochemistry. 86: 442-450
Molecular Cloning of the Brain Ischemia - Inducible Rat Protein Kinase C delta (PKCdelta) and its Activation in Neuronal Preconditioning Models
Kurkinen K. 2002. Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti
Preconditioning with spreading depression activates specifically protein kinase Cdelta
Kurkinen K, Keinänen R, Li W, Koistinaho J. 2001. Neuroreport. 12: 269-273
Genomic structure and chromosomal localization of the rat protein kinase Cdelta-gene
Kurkinen KMA, Keinänen RA, Karhu R, Koistinaho J. 2000. Gene. 242: 115-123

Refine your search

Keywords

Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aß

Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury

Using online game-based platforms to improve student performance and engagement in histology teaching

A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice

Protein kinase C -activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations

Behavioral testing of mice exposed to intermediate frequency magnetic fields indicates mild memory impairment

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death

New Implications for the Role for Ubiquilin-1 in Molecular Mechanisms of Alzheimer's Disease: Interrelationship with BACE1

Effects of Alzheimer's Disease-Associated Risk Loci on Cerebrospinal Fluid Biomarkers and Disease Progression: A Polygenic Risk Score Approach

Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models

Synaptic dysfunction and septin protein family members in neurodegenerative diseases

High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status

Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models

Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's Disease

Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease

Targeting ubiquilin-1 in Alzheimer's disease

Ubiquilin-1 modulates gamma-secretase-mediated epsilon-site cleavage in neuronal cells

Alzheimer's disese-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation

Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation

Prevention of NMDA-induced death of cortical neurons by inhibition of protein kinase Czeta

Molecular Cloning of the Brain Ischemia - Inducible Rat Protein Kinase C delta (PKCdelta) and its Activation in Neuronal Preconditioning Models

Preconditioning with spreading depression activates specifically protein kinase Cdelta

Genomic structure and chromosomal localization of the rat protein kinase Cdelta-gene