KATJA KANNINEN

Contact info

Keywords

RESEARCH GROUPS - UEF

• 
  Neurobiology of disease
• 
  Neuro-Innovation

Links

• Twitter @KanninenL

Publications

• Belaya, Irina; Kucháriková, Nina; Górová, Veronika; Kysenius, Kai; Hare, Dominic J.; Crouch, Peter J.; Malm, Tarja; Atalay, Mustafa; White, Anthony R.; Liddell, Jeffrey R.; Kanninen, Katja M.. 2021. Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer's Disease International journal of molecular sciences 22 16: 8715. 2021
• Puris, Elena; Auriola, Seppo; Korhonen, Paula; Loppi, Sanna; Kanninen, Katja M; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. 2021. Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model Journal of pharmaceutical sciences [In Press, Journal Pre-proof 14.8.]: 30 pages. 2021
• Puris, Elena; Kouril, Štepán; Najdekr, Lukáš; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Friedecký, David; Gynther, Mikko. 2021. Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice Scientific reports 11 1: 13076. 2021
• Talvio, Karo; Kanninen, Katja M; White, Anthony R; Koistinaho, Jari; Castrén, Maija L. 2021. Increased iron content in the heart of the Fmr1 knockout mouse Biometals 34 4: 947-954. 2021
• Keuters, Meike Hedwig; Keksa-Goldsteine, Velta; Dhungana, Hiramani; Huuskonen, Mikko T; Pomeshchik, Yuriy; Savchenko, Ekaterina; Korhonen, Paula K; Singh, Yajuvinder; Wojciechowski, Sara; Lehtonen, Šárka; Kanninen, Katja M; Malm, Tarja; Sirviö, Jouni; Muona, Anu; Koistinaho, Milla; Goldsteins, Gundars; Koistinaho, Jari. 2021. An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo Scientific reports 11 1: 3518. 2021
• Gómez-Budia, Mireia; Konttinen, Henna; Saveleva, Liudmila; Korhonen, Paula; Jalava, Pasi; Kanninen, Katja; Malm, Tarja. 2020. Glial smog: Interplay between air pollution and astrocyte-microglia interactions Neurochemistry international 136: 104715. 2020
• White, Anthony; Kanninen, Katja; Malm, Tarja; Schins, Roel. 2020. Editorial: Air Pollution and Brain Health Neurochemistry international 141: 104900. 2020
• Loppi, Sanna; Korhonen, Paula; Bouvy-Liivrand, Maria; Cagliola, Simone; Turunen, Tiia A; Turunen, Mikko P; Hernandez de Sande, Ana; Kolosowska, Natalia; Scoyni, Flavia; Rosell, Anna; García-Berrocoso, Teresa; Lemarchant, Sighild; Dhungana, Hiramani; Montaner, Joan; Koistinaho, Jari; Kanninen, Katja M; Kaikkonen, Minna U; Giugno, Rosalba; Heinäniemi, Merja; Malm, Tarja. 2020. Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals Aging cell 2021; 20 1: e13287. 2020
• Kolosowska, Natalia; Gotkiewicz, Maria; Dhungana, Hiramani; Giudice, Luca; Giugno, Rosalba; Box, Daphne; Huuskonen, Mikko T.; Korhonen, Paula; Scoyni, Flavia; Kanninen, Katja M.; Ylä-Herttuala, Seppo; Turunen, Tiia A.; Turunen, Mikko P.; Koistinaho, Jari; Malm, Tarja. 2020. Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation Journal of neuroinflammation 17: 194. 2020
• Kanninen, KM; Lampinen, R; Rantanen, LM; Odendaal, L; Jalava, P; Chew, S; White, AR. 2020. Olfactory cell cultures to investigate health effects of air pollution exposure: implications for neurodegeneration Neurochemistry international 136: 104729. 2020
• Doccini, S; Morani, F; Nesti, C; Pezzini, F; Calza, G; Soliymani, R; Signore, G; Rocchiccioli, S; Kanninen, KM; Huuskonen, MT; Baumann, MH; Simonati, A; Lalowski, MM; Santorelli, FM. 2020. Proteomic and functional analyses in disease models reveal CLN5 protein involvement in mitochondrial dysfunction Cell death discovery 6 1: 18. 2020
• Chew, Sweelin; Lampinen, Riikka; Saveleva, Liudmila; Korhonen, Paula; Mikhailov, Nikita; Grubman, Alexandra; Polo, Jose M; Wilson, Trevor; Komppula, Mika; Rönkkö, Teemu; Gu, Cheng; Mackay-Sim, Alan; Malm, Tarja; White, Anthony R; Jalava, Pasi; Kanninen, Katja M. 2020. Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells Particle and fibre toxicology 17 1: 18. 2020
• Chew, S; Kolosowska, N; Saveleva, L; Malm, T; Kanninen, KM. 2020. Impairment of mitochondrial function by particulate matter: Implications for the brain Neurochemistry international 135: 104694. 2020
• Carare, RO; Aldea, R; Agarwal, N; Bacskai, BJ; Bechman, I; Boche, D; Bu, G; Bulters, D; Clemens, A; Counts, SE; de Leon, M; Eide, PK; Fossati, S; Greenberg, SM; Hamel, E; Hawkes, CA; Koronyo-Hamaoui, M; Hainsworth, AH; Holtzman, D; Ihara, M; et al [incl. Kanninen, K; Leinonen, V; Malm, T]. 2020. Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy Alzheimer's & dementia : diagnosis, assessment & disease monitoring 21 1: e12053. 2020
• Belaya, Irina; Ivanova, Mariia; Sorvari, Annika; Ilicic, Marina; Loppi, Sanna; Koivisto, Hennariikka; Varricchio, Alessandra; Tikkanen, Heikki; Walker, Frederick R; Atalay, Mustafa; Malm, Tarja; Grubman, Alexandra; Tanila, Heikki; Kanninen, Katja M. 2020. Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease Journal of neuroinflammation 17 1: 271. 2020
• Konttinen, H; Cabral-da-Silva, MEC; Ohtonen, S; Wojciechowski, S; Shakirzyanova, A; Caligola, S; Giugno, R; Ishchenko, Y; Hernández, D; Fazaludeen, MF; Eamen, S; Budia, MG; Fagerlund, I; Scoyni, F; Korhonen, P; Huber, N; Haapasalo, A; Hewitt, AW; Vickers, J; Smith, GC; et al.. 2019. PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia Stem cell reports 13 4: 669-683. 2019
• Korhonen, P; Pollari, E; Kanninen, KM; Savchenko, E; Lehtonen, Š; Wojciechowski; S; Pomeshchik, Y; Van Den Bosch, L; Goldsteins, G; Koistinaho, J; Malm, T. 2019. Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis IBRO Reports 6: 74-86. 2019
• Oksanen, M; Hyötyläinen, I; Trontti, K; Rolova, T; Wojciechowski, S; Koskuvi, M; Viitanen, M; Levonen, AL; Hovatta, I; Roybon, L; Lehtonen, Š; Kanninen, KM; Hämäläinen, RH; Koistinaho, J. 2019. NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes Glia 2020; 68 3: 589-599. 2019
• Singh, Y; Leinonen, H; Fazaludeen, F; Jaronen, M; Guest, D; Buckley, N; Byts, N; Oksa, P; Jalkanen, K; Iqbal, I; Huuskonen, M; Savchenko, E; Keksa-Goldsteine, V; Chew, S; Myllyharju, J; Tanila, H; Ooi, L; Koistinaho, J; Kanninen, KM; Malm, T. 2019. Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice Human molecular genetics 28 11: 3309-3322. 2019
• Konttinen, H; Gureviciene, I; Oksanen, M; Grubman, A; Loppi, S; Huuskonen, MT; Korhonen, P; Lampinen, R; Keuters, M; Belaya, I; Tanila, H; Kanninen, KM; Goldsteins, G; Landreth, G; Koistinaho, J; Malm, T. 2018. PPARß/DELTA-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes GLIA 2019; 67 1: 146-159. 2018
• Mitochondrial Function in Alzheimer's Disease: Focus on Astrocytes. Lampinen, Riikka; Belaya, Irina; Boccuni, Isabella; Malm, Tarja; Kanninen, Katja M / Astrocyte: Physiology and Pathology. 2018. 2018
• Loppi, S; Kolosowska, N; Kärkkäinen, O; Korhonen, P; Huuskonen, M; Grubman, A; Dhungana, H; Wojciechowski, S; Pomeshchik, Y; Giordano, M; Kagechika, H; White, A; Auriola, S; Koistinaho, J; Landreth, G; Hanhineva, K; Kanninen, K; Malm, T. 2018. HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage Brain, behavior, and immunity 73: 670-681. 2018
• Belaya, Irina; Suwa, Masataka; Chen, Tao; Giniatullin, Rashid; Kanninen, Katja; Atalay, Mustafa; Kumagai, Shuzo. 2018. Long-term exercise protects against cellular stresses in aged mice. Oxidative Medicine and Cellular Longevity 2018: 2894247. 2018
• Gynther, Mikko; Puris, Elena; Peltokangas, Soile; Auriola, Seppo; Kanninen, Katja M; Koistinaho, Jari; Huttunen, Kristiina M; Ruponen, Marika; Vellonen, Kati-Sisko. 2018. Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes PHARMACEUTICAL RESEARCH 2019; 36: 17. 2018
• Choo, Xin Yi; Liddell, Jeffrey R; Huuskonen, Mikko T; Grubman, Alexandra; Moujalled, Diane; Roberts, Jessica; Kysenius, Kai; Patten, Lauren; Quek, Hazel; Oikari, Lotta E; Duncan, Clare; James, Simon A; McInnes, Lachlan E; Hayne, David J; Donnelly, Paul S; Pollari, Eveliina; Vähätalo, Suvi; Lejavová, Katarína; Kettunen, Mikko I; Malm, Tarja; et al. [Incl Koistinaho, Jari; Kanninen, Katja]. 2018. CuII(atsm) Attenuates Neuroinflammation Frontiers in neuroscience 12: 668. 2018
• Abdalkader, Moataz; Lampinen, Riikka; Kanninen, Katja M; Malm, Tarja M; Liddell, Jeffrey R. 2018. Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration Frontiers in Neuroscience 12: 466. 2018
• Vellonen KS, Ihalainen J, Boucau M-C, Gosselet F, Picardat T, Gynther M, Kanninen KM, White AR, Malm T, Koistinaho J, Forsberg MM, Ruponen M. 2017. Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease. PHARMACEUTICAL RESEARCH 34 12: 2652-2662. 2017
• Savchenko E, Singh Y, Konttinen H, Lejavova K, Mediavilla Santos L, Grubman A, Kärkkäinen V, Keksa-Goldsteine V, Naumenko N, Tavi P, White AR, Malm TM, Koistinaho J, Kanninen KM. 2017. Loss of CLN5 causes altered neurogenesis in a childhood neurodegenerative disorder. Disease models & mechanisms 10 9: 1089-1100. 2017
• Oksanen M, Petersen AJ, Naumenko N, Puttonen K, Lehtonen Š, Gubert Olivé M, Shakirzyanova A, Leskelä S, Sarajärvi T, Viitanen M, Rinne JO, Hiltunen M, Haapasalo A, Giniatullin R, Tavi P, Zhang SC, Kanninen KM, Hämäläinen RH, Koistinaho J. 2017. PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease. Stem Cell Reports 9 6: 1885-1897. 2017
• Nissinen J, Andrade P, Natunen T, Hiltunen M, Malm T, Kanninen K, Soares JI, Shatilloa O, Sallinen J, Ndode-Ekanea XE, Pitkänen A. 2017. Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy. EPILEPSY RESEARCH 136: 18-34. 2017
• Leinonen Henri, Keksa-Goldsteine Velta, Ragauskas Symantas, Kohlmann Philip, Signh Yajuvinder, Savchencko Ekaterina, Puranen Jooseppi, Malm Tarja, Kalesnykas Giedrius, Koistinaho Jari, Tanila Heikki, Kanninen Katja M. 2017. Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy. Scientific Reports 7: 1597. 2017
• Konttinen Henna, Lejavová Katarína, Malm Tarja, Kanninen Katja M. 2017. Metals and lysosomal storage disorders. In: White Anthony R, Aschner Michael, Costa Lucio G, Bush Ashley I (ed.) Biometals in neurodegenerative diseases : mechanisms and therapeutics. Academic press. s. 195-215. 2017
• Kanninen KM, White AR. 2017. Type-I interferons in Parkinson's disease: innate inflammatory response drives fate of neurons in model of degenerative brain disorder: An editorial comment on 'Type-I interferons mediate the neuroinflammatory response and neurotoxicity induced by rotenone' Journal of neurochemistry 141 1: 9-11. 2017
• Kanninen Katja M, White Anthony R. 2017. Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases. In: White Anthony R, Aschner Michael, Costa Lucio G, Bush Ashley I (ed.) Biometals in neurodegenerative diseases : mechanisms and therapeutics. Academic press. s. 415-438. 2017
• Huuskonen, MT; Tuo, QZ; Loppi, S; Dhungana, H; Korhonen, P; McInnes, LE; Donnelly, PS; Grubman, A; Wojciechowski, S; Lejavova, K; Pomeshchik, Y; Periviita, L; Kosonen, L; Giordano, M; Walker, FR; Liu, R; Bush, AI; Koistinaho, J; Malm, T; White, AR; et al.. 2017. The Copper bis(thiosemicarbazone) Complex Cu(II)(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu NEUROTHERAPEUTICS 14 2: 519-532. 2017
• Dhungana Hiramani, Huuskonen Mikko T, Pihlajaniemi Taina, Heljasvaara Ritva, Vivien Denis, Kanninen Katja M, Malm Tarja, Koistinaho Jari, Lemarchant Sighild. 2017. Lack of collagen XV is protective after ischemic stroke in mice. Cell Death and Disease 8 January: 1-8. 2017
• Dhungana H, Huuskonen MT, Jaronen M, Lemarchant S, Ali H, Keksa-Goldsteine V, Goldsteins G, Kanninen KM, Koistinaho J, Malm T. 2017. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 14 11: 237. 2017
• Malm Tarja, Loppi Sanna, Kanninen Katja M. 2016. Exosomes in Alzheimer's disease NEUROCHEMISTRY INTERNATIONAL 97: 193-199. 2016
• Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. 2016. Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. MOLECULAR NEURODEGENERATION 11: 15. 2016
• Liddell Jeffrey R, Lehtonen Sarka, Duncan Clare, Keksa-Goldsteine Velta, Levonen Anna-Liisa, Goldsteins Gundars, Malm Tarja, White Anthony R, Koistinaho Jari, Kanninen Katja M. 2016. Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 13 49: 1-14. 2016
• Huuskonen MT, Loppi S, Dhungana H, Keksa-Goldsteine V, Lemarchant S, Korhonen P, Wojciechowski S, Pollari E, Valonen P, Koponen J, Takashima A, Landreth G, Goldsteins G, Malm T, Koistinaho J, Kanninen KM. 2016. Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy Scientific Reports 6: 33176. 2016
• Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. 2016. ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. MOLECULAR NEURODEGENERATION 11: 10. 2016
• Grubman Alexandra, Kanninen Katja M, Malm Tarja. 2016. Multitasking Microglia and Alzheimer's Disease: Diversity, Tools and Therapeutic Targets. JOURNAL OF MOLECULAR NEUROSCIENCE 60 3: 390-404. 2016
• Lemarchant S, Dunghana H, Pomeshchik Y, Leinonen H, Kolosowska N, Korhonen P, Kanninen KM, García-Berrocoso T, Montaner J, Malm T, Koistinaho J. 2016. Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke. GLIA 64 9: 1492-507. 2016
• Kanninen K, Malm T. 2016. Eksosomit aivosairauksissa - solujenvälisen kommunikoinnin uusi muoto. DUODECIM 132 21: 1957-63. 2016
• Kanninen Katja M, Bister Nea, Koistinaho Jari, Malm Tarja. 2015. Exosomes as new diagnostic tools in CNS diseases. BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR BASIS OF DISEASE 2016; 1862 3: 403-410. 2015
• Kanninen Katja M, Pomeshchik Yuriy, Leinonen Hanna, Malm Tarja, Koistinaho Jari, Levonen Anna-Liisa. 2015. Applications of the Keap1-Nrf2 system for gene and cell therapy. FREE RADICAL BIOLOGY & MEDICINE 88 Part B: 350-361. 2015
• Korhonen Paula, Kanninen Katja M, Lehtonen Sarka, Lemarchant Sighild, Puttonen Katja A, Oksanen Minna, Dhungana Hiramani, Loppi Sanna, Pollari Eveliina, Wojciechowski Sara, Kidin Iurii, Garcia-Berrocoso Teresa, Giralt Dolors, Montaner Joan, Koistinaho Jan I, Malm Tarja. 2015. Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation Brain, behavior, and immunity 49: 322-336. 2015
• Rolova Taisia, Dhungana Hiramani, Korhonen Paula, Valonen Piia, Kolosowska Natalia, Konttinen Henna, Kanninen Katja, Tanila Heikki, Malm Tarja, Koistinaho Jari. 2015. Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage. Aging and disease [epub ahead of print 3 Dec 2015]: -. 2015
• White Anthony R, Kanninen Katja M, Crouch Peter J. 2015. Editorial: Metals and neurodegeneration: restoring the balance. Frontiers in aging neuroscience 7: 127. 2015
• Grubman Alexandra, Lidgerwood Grace E, Duncan Clare, Bica Laura, Tan Jiang-Li, Parker Sarah J, Caragounis Aphrodite, Meyerowitz Jodi, Volitakis Irene, Moujalled Diane, Liddell Jeffrey R, Hickey James L, Horne Malcolm, Longmuir Shoshanah, Koistinaho Jari, Donnelly Paul S, Crouch Peter J, Tammen Imke, White Anthony R, Kanninen Katja M. 2014. Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder. Acta neuropathologica communications 2014 Feb 28:2:25: --. 2014
• Grubman Alexandra, Pollari Eveliina, Duncan Clare, Caragounis Aphrodite, Blom Tea, Volitakis Irene, Wong Andrew, Cooper Jonathan, Crouch Peter J, Koistinaho Jari, Jalanko Anu, White Anthony R, Kanninen Katja M. 2014. Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?. Metallomics 2014 Apr;6(4): 932-943. 2014
• Kärkkäinen Virve, Pomeshchik Yuriy, Savchenko Ekaterina, Dhungana Hiramani, Kurronen Antti, Lehtonen Sarka, Naumenko Nikolay, Tavi Pasi, Levonen Anna-Liisa, Yamamoto Masayaki, Malm Tarja, Magga Johanna, Kanninen Katja M, Koistinaho Jari. 2014. Nrf2 regulates neurogenesis and protects neural progenitor cells against aß toxicity. STEM CELLS 32 7: 1904-1916. 2014
• Moujalled Diane, James Janine L, Yang Shu, Zhang Katharine, Duncan Clare, Moujalled Donia M, Parker Sarah J, Caragounis Aphrodite, Lidgerwood Grace, Turner Bradley J, Atkin Julie D, Grubman Alexandra, Liddell Jeffrey R, Proepper Christian, Boeckers Tobias M, Kanninen Katja M, Blair Ian, Crouch Peter J, White Anthony R. 2014. Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43. HUMAN MOLECULAR GENETICS 2015; 24 6: 1655-1669. 2014
• Pomeshchik Y, Kidin I, Korhonen P, Savchenko E, Jaronen M, Lehtonen S, Wojciechowski S, Kanninen K, Koistinaho J, Malm T. 2014. Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury. Brain, behavior, and immunity 2014 Aug 18 ePub ahead of print: --. 2014
• Roberts Blaine R, Lim Nastasia KH, McAllum Erin J, Donnelly Paul S, Hare Dominic J, Doble Philip A, Turner Bradley J, Price Katherine A, Lim Sin Chun, Paterson Brett M, Hickey James L, Rhoads Timothy W, Williams Jared R, Kanninen Katja M, Hung Lin W, Liddell Jeffrey R, Grubman Alexandra, Monty Jean-Francois, Llanos Roxana M, Kramer David R, Mercer Julian FB, Bush Ashley I, Masters Colin L, Duce Ja. 2014. Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis. JOURNAL OF NEUROSCIENCE 2014 Jun 4;34(23): 8021-8031. 2014
• Grubman A, James SA, James J, Duncan C, Volitakis I, Hickey JL, Crouch PJ, Donnelly PS, Kanninen KM, Liddell JR, Cotman SL, de Jonge MD, White AR. 2014. X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder. Chemical science 2014 Jun;5(6): 2503-2516. 2014
• Pomeshchik Y, Kidin I, Savchenko E, Rolova T, Yamamoto M, Levonen AL, Ylä-Herttuala S, Malm T, Kanninen K, Koistinaho J. 2013. Does Nrf2 Gene Transfer Facilitate Recovery After Contusion Spinal Cord Injury?. ANTIOXIDANTS AND REDOX SIGNALING 2013 Aug 20. [Epub ahead of print]: x-x. 2013
• Rolova T, Puli L, Magga J, Dhungana H, Kanninen K, Wojciehowski S, Salminen A, Tanila H, Koistinaho J, Malm T. 2013. Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) [Epub ahead of print] 64C: 16-29. 2013
• Lemarchant S, Pruvost M, Montaner J, Emery E, Vivien D, Kanninen K, Koistinaho J. 2013. ADAMTS proteoglycanases in the physiological and pathological central nervous system. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 2013 Oct 31;10(1): 133. 2013
• Parker SJ, Koistinaho J, White AR, Kanninen KM. 2013. Biometals in rare neurodegenerative disorders of childhood. Frontiers in aging neuroscience 5 14: x-x. 2013
• Moujalled D, James JL, Parker SJ, Lidgerwood GE, Duncan C, Meyerowitz J, Nonaka T, Hasegawa M, Kanninen KM, Grubman A, Liddell JR, Crouch PJ, White AR. 2013. Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress. PLOS ONE [ONLINE] 8(6): e67433.: e67433. 2013
• Kanninen KM, Grubman A, Meyerowitz J, Duncan C, Tan JL, Parker SJ, Crouch PJ, Paterson BM, Hickey JL, Donnelly PS, Volitakis I, Tammen I, Palmer DN, White AR. 2013. Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis. PLOS ONE [ONLINE] 8 3: e58644. 2013
• Kurronen A, Pihlaja R, Pollari E, Kanninen K, Storvik M, Wong G, Koistinaho M, Koistinaho J. 2012. Adult and neonatal astrocytes exhibit diverse gene expression profiles in response to beta amyloid ex vivo. World Journal of Neuroscience 2/2012: 57-67. 2012
• Kanninen K, White AR, Koistinaho J, Malm T. 2011. Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway International Journal of Alzheimer's Disease 2011;2011:985085. Epub 2011 May 2: --. 2011
• Malm T, Koistinaho J, Kanninen K. 2011. Utilization of APPswe/PS1dE9 Transgenic Mice in Research of Alzheimer's Disease: Focus on Gene Therapy and Cell-Based Therapy Applications International Journal of Alzheimer's Disease 2011;2011:517160. Epub 2011 Oct 30: --. 2011
• Pollari Eveliina, Savchenko Ekaterina, Jaronen Merja, Kanninen Katja, Malm Tarja, Wojciechowski Sara, Ahtoniemi Toni, Goldsteins Gundars, Giniatullina Raisa, Giniatullin Rashid, Koistinaho Jari, Magga Johanna. 2011. Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 84: 1-14. 2011
• Magga J, Puli L, Pihlaja R, Kanninen K, Neulamaa S, Malm T, Härtig W, Grosche J, Goldsteins G, Tanila H et al. 2010. Human intravenous immunoglobulin provides protection against Aβ toxicity by multiple mechanisms in a mouse model of Alzheimer's disease. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 7: 90. 2010
• Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J. 2009. Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106 38: 16505-16510. 2009
• Kanninen K. 2009. Nrf2 in Alzheimer's Disease. Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti. 2009
• Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL, Koistinaho J. 2008. Nuclear factor erythroid 2-related factor 2 protects against beta amyloid. MOLECULAR AND CELLULAR NEUROSCIENCE (SAN DIEGO CA) 39 3: 302-313. 2008
• Ahtoniemi T, Goldsteins G, Keksa-Goldsteine V, Malm T, Kanninen K, Salminen A, Koistinaho J. 2007. Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis MOLECULAR PHARMACOLOGY 71: 30-37. 2007
• Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, van Groen T, Tanila H, Koistinaho J. 2007. Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden JOURNAL OF NEUROSCIENCE 27 14: 3712-3721. 2007
• Malm T, Ort M, Tähtivaara L, Jukarainen N, Goldsteins G, Puoliväli J, Nurmi A, Pussinen R, Ahtoniemi T, Miettinen T-K, Kanninen K, Leskinen S, Vartiainen N, Yrjänheikki J, Laatikainen R, Harris-White ME, Koistinaho M, Frautschy SA, Bures J. 2006. Beta-amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 103 23: 8852-8857. 2006
• The Eleventh Annual Post-Graduate Symposium of the A.I. Virtanen Institute Graduate School. AIVI Winter School 2006. Abstracts. Keinänen R, Huttunen J, Häkkinen S-K, Kanninen K, Lipponen A, Louhivuori L, Mäkelä K, Mäntylä T, Tusa M. 2006 2006
• Kanninen K, Goldsteins G, Auriola S, Alafuzoff I, Koistinaho J. 2004. Glycosylation changes in Alzheimer's disease as revealed by a proteomic approach. NEUROSCIENCE LETTERS 367 2: 235-240. 2004