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Katja Kanninen

Katja Kanninen

Professori

A.I. Virtanen -instituutti, Terveystieteiden tiedekunta

[email protected] | 046 921 0065

Tiedot Julkaisut

Johdan ’Soluneurobiologia’ -tutkimusryhmää A.I.Virtanen -instituutissa, jossa toimin professorina. Tutkimme ympäristön vaikutuksia aivoterveyteen ja Alzheimerin tautiin. Käytämme tutkimuksessa potilasperäisiä solumalleja.

Lisätietoa tutkimusryhmästä osoitteessa: https://uefconnect.uef.fi/en/group/cellular-neurobiology/#information

Tutkimusryhmät

Soluneurobiologia 01.01.2017 -

Projektit

Neuro-Innovation 01.05.2021 - 30.04.2026

Avainsanat

aivoterveys Alzheimerin tauti astrosyytit biomarkkerit elintavat gliasolut hajuepiteelisolut ilmansaasteet sairauden neurobiologia ympäristötekijät

Julkaisut

123/123 kappaletta

Importance of sub-23 nm particles in traffic environments: Particle number emission factors and extrathoracic deposition doses
Lintusaari, Henna; Lepistö, Teemu; Saarikoski, Sanna; Salo, Laura; Silvonen, Ville; Barreira, Luis M.F.; Aurela, Minna; Hoivala, Jussi; Markkula, Lassi; Ondracek, Jakub; Wahle, Tina; Vojtisek-Lom, Michal; Topinka, Jan; Schins, Roel PF; Jalava, Pasi; Timonen, Hilkka; Kanninen, Katja M; Rönkkö, Topi. 2025. Environmental pollution. 369: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
A technological comparison of freeze-dried poly-ɛ-caprolactone (PCL) and poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with clozapine for nose-to-brain delivery
Lombardo, Rosamaria; Ruponen, Marika; Rautio, Jarkko; Lampinen, Riikka; Kanninen, Katja M.; Koivisto, Anne M.; Penttilä, Elina; Löppönen, Heikki; Demartis, Sara; Giunchedi, Paolo; Rassu, Giovanna; Fragalà, Maria Elena; Pignatello, Rosario. 2024. Journal of drug delivery science and technology. 93: . 105419 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Adverse outcome pathway for the neurotoxicity of Per- and polyfluoroalkyl substances: A systematic review
Li, Shenpan; Qin, Shuangjian; Zeng, Huixian; Chou, Weichun; Oudin, Anna; Kanninen, Katja M.; Jalava, Pasi; Dong, Guanghui; Zeng, Xiaowen. 2024. Eco-environment & health. 3: 476-493 A2 Katsausartikkeli tieteellisessä aikakauslehdessä
Blood cytokines in major depressive disorder in drug-naïve adolescents: A systematic review and meta-analysis
Jadhav, Kaustubh Kishor; Daouk, Joud; Kurkinen, Karoliina; Kraav, Siiri-Liisi; Eriksson, Päivi; Tolmunen, Tommi; Kanninen, Katja M. 2024. Journal of affective disorders. 2025; 372: 48-55 A2 Katsausartikkeli tieteellisessä aikakauslehdessä
Circular RNA circ_0061183 regulates microglial polarization induced by airborne ultrafine particles in HMC3 cells via sponging miR-98-5p
Zeng, Hui-Xian; Qin, Shuang-Jian; Wu, Qi-Zhen; Zeng, Qing-Guo; Li, Jia-Hui; Oudin, Anna; Kanninen, Katja M.; Yang, Mo; Jalava, Pasi; Dong, Guang-Hui; Zeng, Xiao-Wen. 2024. Journal of hazardous materials. 2025; 484: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Exposure to source-specific air pollution in residential areas and its association with dementia incidence: a cohort study in Northern Sweden
Oudin, Anna; Raza, Wasif; Flanagan, Erin; Segersson, David; Jalava, Pasi; Kanninen, Katja M.; Rönkkö, Topi; Giugno, Rosalba; Sandström, Thomas; Muala, Ala; Topinka, Jan; Sommar, Johan. 2024. Scientific reports. 14: . 15521 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Exposure to urban particulate matter alters responses of olfactory mucosal cells to SARS-CoV-2 infection
Shahbaz, Muhammad Ali; Kuivanen, Suvi; Mussalo, Laura; Afonin, Alexey M; Kumari, Kajal; Behzadpour, Donya; Kalapudas, Juho; Koivisto, Anne M; Penttilä, Elina; Löppönen, Heikki; Jalava, Pasi; Vapalahti, Olli; Balistreri, Giuseppe; Lampinen, Riikka; Kanninen, Katja M. 2024. Environmental research. 249: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Increased Expression of Transferrin Receptor 1 in the Brain Cortex of 5xFAD Mouse Model of Alzheimer’s Disease Is Associated with Activation of HIF-1 Signaling Pathway
Petralla, Sabrina; Saveleva, Liudmila; Kanninen, Katja M; Oster, Julia S; Panayotova, Maria; Fricker, Gert; Puris, Elena. 2024. Molecular neurobiology. 61: 6383-6394 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles
Drouard, Gabin; Wang, Zhiyang; Heikkinen, Aino; Foraster, Maria; Julvez, Jordi; Kanninen, Katja M.; van Kamp, Irene; Pirinen, Matti; Ollikainen, Miina; Kaprio, Jaakko. 2024. Scientific reports. 14: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Long-term exposure to major constituents of fine particulate matter and neurodegenerative diseases: A population-based survey in the Pearl River Delta Region, China
Wu, Qi-Zhen; Zeng, Hui-Xian; Andersson, John; Oudin, Anna; Kanninen, Katja M.; Xu, Mu-Wu; Qin, Shuang-Jian; Zeng, Qing-Guo; Zhao, Bin; Zheng, Mei; Jin, Nanxiang; Chou, Wei-Chun; Jalava, Pasi; Dong, Guang-Hui; Zeng, Xiao-Wen. 2024. Journal of hazardous materials. 470: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Metabolic profiles associated with exposure to ambient particulate air pollution: findings from the Betula cohort
Raza, Wasif; Öhman, Anders; Kanninen, Katja M; Jalava, Pasi; Zeng, Xiao-wen; de Crom, Tosca OE; Ikram, M Arfan; Oudin, Anna. 2024. Frontiers in public health. 12: . 1401006 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Neurotoxicity of fine and ultrafine particulate matter: A comprehensive review using a toxicity pathway-oriented adverse outcome pathway framework
Qin, Shuang-Jian; Zeng, Qing-Guo; Zeng, Hui-Xian; Li, Shen-Pan; Andersson, John; Zhao, Bin; Oudin, Anna; Kanninen, Katja M; Jalava, Pasi; Jin, Nan-Xiang; Yang, Mo; Lin, Li-Zi; Liu, Ru-Qing; Dong, Guang-Hui; Zeng, Xiao-Wen. 2024. Science of the total environment. 947: A2 Katsausartikkeli tieteellisessä aikakauslehdessä
Particulate matter from car exhaust alters function of human iPSC-derived microglia
Jäntti, Henna; Jonk, Steffi; Gómez Budia, Mireia; Ohtonen, Sohvi; Fagerlund, Ilkka; Fazaludeen, Mohammad Feroze; Aakko-Saksa, Päivi; Pebay, Alice; Lehtonen, Šárka; Koistinaho, Jari; Kanninen, Katja M; Jalava, Pasi I; Malm, Tarja; Korhonen, Paula. 2024. Particle and fibre toxicology. 21: . 6 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Proteomic insights into mental health status: plasma markers in young adults
Afonin, Alexey M; Piironen, Aino-Kaisa; de Sousa Maciel, Izaque; Ivanova, Mariia; Alatalo, Arto; Whipp, Alyce M; Pulkkinen, Lea; Rose, Richard J; van Kamp, Irene; Kaprio, Jaakko; Kanninen, Katja M. 2024. Translational psychiatry. 14: . 55 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Sex-specific changes in protein expression of membrane transporters in the brain cortex of 5xFAD mouse model of Alzheimer’s disease
Puris, Elena; Saveleva, Liudmila; Auriola, Seppo; Gynther, Mikko; Kanninen, Katja M; Fricker, Gert. 2024. Frontiers in pharmacology. 15: . 1365051 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
The association between oral diseases and neurodegenerative disorders
Soiniemi, Lauriina; Solje, Eino; Suominen, Anna Liisa; Kanninen, Katja M; Kullaa, Arja M. 2024. Journal of Alzheimer's disease. 102: 577-586 A2 Katsausartikkeli tieteellisessä aikakauslehdessä
The emerging roles of particulate matter-changed non-coding RNAs in the pathogenesis of Alzheimer's disease: A comprehensive in silico analysis and review
Zeng, Hui-Xian; Qin, Shuang-Jian; Andersson, John; Li, Shen-Pan; Zeng, Qing-Guo; Li, Jia-Hui; Wu, Qi-Zhen; Meng, Wen-Jie; Oudin, Anna; Kanninen, Katja M.; Jalava, Pasi; Dong, Guang-Hui; Zeng, Xiao-Wen. 2024. Environmental pollution. 2025; 366: A2 Katsausartikkeli tieteellisessä aikakauslehdessä
Traffic-related ultrafine particles impair mitochondrial functions in human olfactory mucosa cells – Implications for Alzheimer's disease
Mussalo, Laura; Lampinen, Riikka; Avesani, Simone; Závodná, Táňa; Krejčík, Zdeněk; Kalapudas, Juho; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Malm, Tarja; Topinka, Jan; Giugno, Rosalba; Jalava, Pasi; Kanninen, Katja M. 2024. Redox biology. 75: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Transcriptomic and epigenomic profiling reveals altered responses to diesel emissions in Alzheimer's disease both in vitro and in population-based data
Saveleva, Liudmila; Cervena, Tereza; Mengoni, Claudia; Sima, Michal; Krejcik, Zdenek; Vrbova, Kristyna; Sikorova, Jitka; Mussalo, Laura; de Crom, Tosca O E; Šímová, Zuzana; Ivanova, Mariia; Shahbaz, Muhammad Ali; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Ikram, M Arfan; Jalava, Pasi I; Malm, Tarja; Chew, Sweelin; Vojtisek‐Lom, Michal; Topinka, Jan; Giugno, Rosalba; Rössner, Pavel; Kanninen, Katja M. 2024. Alzheimer's & dementia. 20: 8825-8843 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse model
Ivanova, Mariia; Belaya, Irina; Kucháriková, Nina; de Sousa Maciel, Izaque; Saveleva, Liudmila; Alatalo, Arto; Juvonen, Ilona; Thind, Navjot; Andrès, Clarisse; Lampinen, Riikka; Chew, Sweelin; Kanninen, Katja M. 2024. Neurobiology of disease. 191: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Adopting a child perspective for exposome research on mental health and cognitive development - Conceptualisation and opportunities
Person Waye, Kerstin; Löve, Jesper; Lercher, Peter; Dzhambov, Angel M.; Klatte, Maria; Schreckenberg, Dirk; Belke, Christin; Leist, Larisa; Ristovska, Gordana; Jeram, Sonja; Kanninen, Katja M.; Selander, Jenny; Arat, Arzu; Lachmann, Thomas; Clark, Charlotte; Botteldooren, Dick; White, Kim; Julvez, Jordi; Foraster, Maria; Kaprio, Jaakko; Bolte, Gabriele; Psyllidis, Achilleas; Gulliver, John; Boshuizen, Hendriek; Bozzon, Alessandro; Fels, Janina; Hornikx, Maarten; van den Hazel, Peter; Weber, Miri. 2023. Environmental research. 239: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Dynamic release of neuronal extracellular vesicles containing miR‐21a‐5p is induced by hypoxia
Korvenlaita, Nea; Gómez‐Budia, Mireia; Scoyni, Flavia; Pistono, Cristiana; Giudice, Luca; Eamen, Shaila; Loppi, Sanna; de Sande, Ana Hernández; Huremagic, Benjamin; Bouvy‐Liivrand, Maria; Heinäniemi, Merja; Kaikkonen, Minna U.; Cheng, Lesley; Hill, Andrew F.; Kanninen, Katja M.; Jenster, Guido W.; van Royen, Martin E.; Ramiro, Laura; Montaner, Joan; Batkova, Tereza; Mikulik, Robert; Giugno, Rosalba; Jolkkonen, Jukka; Korhonen, Paula; Malm, Tarja. 2023. Journal of extracellular vesicles. 12: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Emissions from modern engines induce distinct effects in human olfactory mucosa cells, depending on fuel and aftertreatment
Mussalo, Laura; Avesani, Simone; Shahbaz, Muhammad Ali; Zavodna, Tana; Saveleva, Liudmila; Järvinen, Anssi; Lampinen, Riikka; Belaya, Irina; Krejcik, Zdenek; Ivanova, Mariia; Hakkarainen, Henri; Kalapudas, Juho; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Malm, Tarja; Topinka, Jan; Giugno, Rosalba; Aakko-Saksa, Päivi; Chew, Sweelin; Rönkkö, Topi; Jalava, Pasi; Kanninen, Katja M. 2023. Science of the total environment. 905: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Exploring plasma biomarker candidates for mental health risk assessment in adolescents
Piironen, Aino-Kaisa; Kanninen, Katja. 2023. Nature mental health. 1: 532-533 B1 Kirjoitus tieteellisessä aikakauslehdessä
Human-derived air–liquid interface cultures decipher Alzheimer’s disease–SARS-CoV-2 crosstalk in the olfactory mucosa
Shahbaz, Muhammad Ali; Kuivanen, Suvi; Lampinen, Riikka; Mussalo, Laura; Hron, Tomáš; Závodná, Táňa; Ojha, Ravi; Krejčík, Zdeněk; Saveleva, Liudmila; Tahir, Numan Ahmad; Kalapudas, Juho; Koivisto, Anne M; Penttilä, Elina; Löppönen, Heikki; Singh, Prateek; Topinka, Jan; Vapalahti, Olli; Chew, Sweelin; Balistreri, Giuseppe; Kanninen, Katja M. 2023. Journal of neuroinflammation. 20: . 299 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins
Drouard, Gabin; Hagenbeek, Fiona A; Whipp, Alyce M.; Pool, René; Hottenga, Jouke Jan; Jansen, Rick; Hubers, Nikki; Afonin, Aleksei; Willemsen, Gonneke; de Geus, Eco JC; Ripatti, Samuli; Pirinen, Matti; Kanninen, Katja M; Boomsma, Dorret I; van Dongen, Jenny; Kaprio, Jaakko. 2023. Bmc medicine. 21: . 508 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Plasma proteomics discovery of mental health risk biomarkers in adolescents
de Sousa Maciel, Izaque; Piironen, Aino-Kaisa; Afonin, Alexey M; Ivanova, Mariia; Alatalo, Arto; Jadhav, Kaustubh Kishor; Julvez, Jordi; Foraster, Maria; van Kamp, Irene; Kanninen, Katja M. 2023. Nature mental health. 1: 596-605 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Protective effect of restorative possibilities on cognitive function and mental health in children and adolescents: A scoping review including the role of physical activity
Dzhambov, Angel M; Lercher, Peter; Vincens, Natalia; Persson Waye, Kerstin; Klatte, Maria; Leist, Larisa; Lachmann, Thomas; Schreckenberg, Dirk; Belke, Christin; Ristovska, Gordana; Kanninen, Katja M; Botteldooren, Dick; Van Renterghem, Timothy; Jeram, Sonja; Selander, Jenny; Arat, Arzu; White, Kim; Julvez, Jordi; Clark, Charlotte; Foraster, Maria; van Kamp, Irene. 2023. Environmental research. 233: . 116452 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
The Interaction between Circulating Cell-Free Mitochondrial DNA and Inflammatory Cytokines in Predicting Human Mental Health Issue Risk in Adolescents: An Explorative Study
Alatalo, Arto; de Sousa Maciel, Izaque; Kucháriková, Nina; Chew, Sweelin; van Kamp, Irene; Foraster, Maria; Julvez, Jordi; Kanninen, Katja M. 2023. Biomedicines. 11: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Transcriptomic Alterations in the Olfactory Bulb Induced by Exposure to Air Pollution: Identification of Potential Biomarkers and Insights into Olfactory System Function
Saveleva, Liudmila; Sima, Michal; Klema, Jiri; Krejčík, Zdeněk; Vartiainen, Petra; Sitnikova, Valeriia; Belaya, Irina; Malm, Tarja; Jalava, Pasi I; Rössner, Pavel; Kanninen, Katja M. 2023. Environmental toxicology and pharmacology. 104: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
9th Kuopio Alzheimer Symposium and 3rd Nordic Memory Clinic Conference: Program and Abstracts
Kanninen, Katja; Górová, Veronika. 2022. Publications of the University of Eastern Finland. Reports and studies in health sciences. . Itä-Suomen yliopisto D6 Toimitettu ammatillinen teos
Air Pollution Exposure Increases ABCB1 and ASCT1 Transporter Levels in Mouse Cortex
Puris, Elena; Saveleva, Liudmila; Górová, Veronika; Vartiainen, Petra; Kortelainen, Miika; Lamberg, Heikki; Sippula, Olli; Malm, Tarja; Jalava, Pasi I; Auriola, Seppo; Fricker, Gert; Kanninen, Katja M. 2022. Environmental toxicology and pharmacology. 96: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
An Alzheimer’s Disease Patient-Derived Olfactory Stem Cell Model Identifies Gene Expression Changes Associated with Cognition
Rantanen, Laura M.; Bitar, Maina; Lampinen, Riikka; Stewart, Romal; Quek, Hazel; Oikari, Lotta E.; Cunί-Lόpez, Carla; Sutharsan, Ratneswary; Thillaiyampalam, Gayathri; Iqbal, Jamila; Russell, Daniel; Penttilä, Elina; Löppönen, Heikki; Lehtola, Juha-Matti; Saari, Toni; Hannonen, Sanna; Koivisto, Anne M.; Haupt, Larisa M.; Mackay-Sim, Alan; Cristino, Alexandre S.; Kanninen, Katja M.; White, Anthony R.. 2022. Cells. 11: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Biometal Dyshomeostasis in Olfactory Mucosa of Alzheimer’s Disease Patients
Lampinen, Riikka; Górová, Veronika; Avesani, Simone; Liddell, Jeffrey R; Penttilä, Elina; Závodná, Táňa; Krejčík, Zdeněk; Lehtola, Juha-Matti; Saari, Toni; Kalapudas, Juho; Hannonen, Sanna; Löppönen, Heikki; Topinka, Jan; Koivisto, Anne M; White, Anthony R; Giugno, Rosalba; Kanninen, Katja M. 2022. International journal of molecular sciences. 23: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Early environmental quality and life-course mental health effects: The Equal-Life project
Kamp, Irene van; Persson Waye, Kerstin; Kanninen, Katja; Gulliver, John; Bozzon, Alessandro; Psyllidis, Achilleas; Boshuizen, Hendriek; Selander, Jenny; van den Hazel, Peter; Brambilla, Marco; Foraster, Maria; Julvez, Jordi; Klatte, Maria; Jeram, Sonja; Lercher, Peter; Botteldooren, Dick; Ristovska, Gordana; Kaprio, Jaakko; Schreckenberg, Dirk; Hornikx, Maarten; Fels, Janina; Weber, Miriam; Braat-Eggen, Ella; Hartmann, Julia; Clark, Charlotte; Vrijkotte, Tanja; Brown, Lex; Bolte, Gabriele; Equal. 2022. Environmental epidemiology. 6: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease
Gynther, Mikko; Estrada, Mariana Leal; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Auriola, Seppo; Fricker, Gert; Puris, Elena. 2022. Pharmaceutics. 14: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Lysosomal Proteomics Links Disturbances in Lipid Homeostasis and Sphingolipid Metabolism to CLN5 Disease
Doccini, Stefano; Marchese, Maria; Morani, Federica; Gammaldi, Nicola; Mero, Serena; Pezzini, Francesco; Soliymani, Rabah; Santi, Melissa; Signore, Giovanni; Ogi, Asahi; Rocchiccioli, Silvia; Kanninen, Katja M.; Simonati, Alessandro; Lalowski, Maciej M.; Santorelli, Filippo M.. 2022. Cells. 11: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Mechanistic Understanding of the Olfactory Neuroepithelium Involvement Leading to Short-Term Anosmia in COVID-19 Using the Adverse Outcome Pathway Framework
Shahbaz, Muhammad Ali; De Bernardi, Francesca; Alatalo, Arto; Sachana, Magdalini; Clerbaux, Laure-Alix; Muñoz, Amalia; Parvatam, Surat; Landesmann, Brigitte; Kanninen, Katja M.; Coecke, Sandra. 2022. Cells. 11: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Metabolomic, Lipidomic and Proteomic Characterisation of Lipopolysaccharide-induced Inflammation Mouse Model
Puris, Elena; Kouřil, Štěpán; Najdekr, Lukáš; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Gómez-Budia, Mireia; Fricker, Gert; Kanninen, Katja M; Malm, Tarja; Friedecký, David; Gynther, Mikko. 2022. Neuroscience. 496: 165-178 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Microglial amyloid beta clearance is driven by PIEZO1 channels
Jäntti, Henna; Sitnikova, Valeriia; Ishchenko, Yevheniia; Shakirzyanova, Anastasia; Giudice, Luca; Ugidos, Irene F; Gómez-Budia, Mireia; Korvenlaita, Nea; Ohtonen, Sohvi; Belaya, Irina; Fazaludeen, Feroze; Mikhailov, Nikita; Gotkiewicz, Maria; Ketola, Kirsi; Lehtonen, Šárka; Koistinaho, Jari; Kanninen, Katja M; Hernández, Damian; Pébay, Alice; Giugno, Rosalba; Korhonen, Paula; Giniatullin, Rashid; Malm, Tarja. 2022. Journal of neuroinflammation. 19: . 147 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Neuron-astrocyte transmitophagy is altered in Alzheimer's disease
Lampinen, Riikka; Belaya, Irina; Saveleva, Liudmila; Liddell, Jeffrey R; Rait, Dzhessi; Huuskonen, Mikko T; Giniatullina, Raisa; Sorvari, Annika; Soppela, Liisi; Mikhailov, Nikita; Boccuni, Isabella; Giniatullin, Rashid; Cruz-Haces, Marcela; Konovalova, Julia; Koskuvi, Marja; Domanskyi, Andrii; Hämäläinen, Riikka H; Goldsteins, Gundars; Koistinaho, Jari; Malm, Tarja; Chew, Sweelin; Rilla, Kirsi; White, Anthony R; Marsh-Armstrong, Nicholas; Kanninen, Katja M. 2022. Neurobiology of disease. 170: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex
Choo, Xin Yi; McInnes, Lachlan E; Grubman, Alexandra; Wasielewska, Joanna M; Belaya, Irina; Burrows, Emma; Quek, Hazel; Martín, Jorge Cañas; Loppi, Sanna; Sorvari, Annika; Rait, Dzhessi; Powell, Andrew; Duncan, Clare; Liddell, Jeffrey R.; Tanila, Heikki; Polo, Jose M; Malm, Tarja; Kanninen, Katja M.; Donnelly, Paul S; White, Anthony R. 2022. International journal of molecular sciences. 23: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer’s Disease
Puris, Elena; Saveleva, Liudmila; de Sousa Maciel, Izaque; Kanninen, Katja M.; Auriola, Seppo; Fricker, Gert. 2022. Molecular neurobiology. 2023; 60: 732-748 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Single-Cell RNA-Seq Analysis of Olfactory Mucosal Cells of Alzheimer’s Disease Patients
Lampinen, Riikka; Fazaludeen, Mohammad Feroze; Avesani, Simone; Örd, Tiit; Penttilä, Elina; Lehtola, Juha-Matti; Saari, Toni; Hannonen, Sanna; Saveleva, Liudmila; Kaartinen, Emma; Fernández Acosta, Francisco; Cruz-Haces, Marcela; Löppönen, Heikki; Mackay-Sim, Alan; Kaikkonen, Minna U; Koivisto, Anne M; Malm, Tarja; White, Anthony R; Giugno, Rosalba; Chew, Sweelin; Kanninen, Katja M. 2022. Cells. 11: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Subacute inhalation of ultrafine particulate matter triggers inflammation without altering amyloid beta load in 5xFAD mice
Saveleva, Liudmila; Vartiainen, Petra; Górová, Veronika; Chew, Sweelin; Belaya, Irina; Konttinen, Henna; Zucchelli, Martina; Korhonen, Paula; Kaartinen, Emma; Kortelainen, Miika; Lamberg, Heikki; Sippula, Olli; Malm, Tarja; Jalava, Pasi I; Kanninen, Katja M. 2022. Neurotoxicology. 89: 55-66 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice
Puris, Elena; Jalkanen, Aaro; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. 2022. Brain disorders. 6: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
TUBE Project: Transport-Derived Ultrafines and the Brain Effects
Martikainen, Maria-Viola; Aakko-Saksa, Päivi; van den Broek, Lenie; Cassee, Flemming R; Carare, Roxana O; Chew, Sweelin; Dinnyes, Andras; Giugno, Rosalba; Kanninen, Katja M; Malm, Tarja; Muala, Ala; Nedergaard, Maiken; Oudin, Anna; Oyola, Pedro; Pfeiffer, Tobias V; Rönkkö, Topi; Saarikoski, Sanna; Sandström, Thomas; Schins, Roel PF; Topinka, Jan; Yang, Mo; Zeng, Xiaowen; Westerink, Remco HS; Jalava, Pasi I. 2022. International journal of environmental research and public health. 19: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
The Adverse Outcome Pathway Framework Applied to Neurological Symptoms of COVID-19
Hogberg, Helena T.; Lam, Ann; Ohayon, Elan; Shahbaz, Muhammad Ali; Clerbaux, Laure-Alix; Bal-Price, Anna; Coecke, Sandra; Concha, Rachel; De Bernardi, Francesca; Edrosa, Eizleayne; Hargreaves, Alan J.; Kanninen, Katja M.; Munoz, Amalia; Pistollato, Francesca; Saravanan, Surat; Garcia-Reyero, Natàlia; Wittwehr, Clemens; Sachana, Magdalini. 2022. Cells. 11: A2 Katsausartikkeli tieteellisessä aikakauslehdessä
An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo
Keuters, Meike Hedwig; Keksa-Goldsteine, Velta; Dhungana, Hiramani; Huuskonen, Mikko T; Pomeshchik, Yuriy; Savchenko, Ekaterina; Korhonen, Paula K; Singh, Yajuvinder; Wojciechowski, Sara; Lehtonen, ¦árka; Kanninen, Katja M; Malm, Tarja; Sirviö, Jouni; Muona, Anu; Koistinaho, Milla; Goldsteins, Gundars; Koistinaho, Jari. 2021. Scientific reports
Increased iron content in the heart of the Fmr1 knockout mouse
Talvio, Karo; Kanninen, Katja M; White, Anthony R; Koistinaho, Jari; Castrén, Maija L. 2021. Biometals
Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice
Puris, Elena; Kouril, ¦tepán; Najdekr, Luká¨; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Friedecký, David; Gynther, Mikko. 2021. Scientific reports
Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer's Disease
Belaya, Irina; Kucháriková, Nina; Górová, Veronika; Kysenius, Kai; Hare, Dominic J.; Crouch, Peter J.; Malm, Tarja; Atalay, Mustafa; White, Anthony R.; Liddell, Jeffrey R.; Kanninen, Katja M.. 2021. International journal of molecular sciences
Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model
Puris, Elena; Auriola, Seppo; Korhonen, Paula; Loppi, Sanna; Kanninen, Katja M; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. 2021. Journal of pharmaceutical sciences
Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease
Belaya, Irina; Ivanova, Mariia; Sorvari, Annika; Ilicic, Marina; Loppi, Sanna; Koivisto, Hennariikka; Varricchio, Alessandra; Tikkanen, Heikki; Walker, Frederick R; Atalay, Mustafa; Malm, Tarja; Grubman, Alexandra; Tanila, Heikki; Kanninen, Katja M. 2020. Journal of neuroinflammation
Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy
Carare, RO; Aldea, R; Agarwal, N; Bacskai, BJ; Bechman, I; Boche, D; Bu, G; Bulters, D; Clemens, A; Counts, SE; de Leon, M; Eide, PK; Fossati, S; Greenberg, SM; Hamel, E; Hawkes, CA; Koronyo-Hamaoui, M; Hainsworth, AH; Holtzman, D; Ihara, M; et al [incl. Kanninen, K; Leinonen, V; Malm, T]. 2020. Alzheimer's & dementia : diagnosis, assessment & disease monitoring
Editorial: Air Pollution and Brain Health
White, Anthony; Kanninen, Katja; Malm, Tarja; Schins, Roel. 2020. Neurochemistry international
Glial smog: Interplay between air pollution and astrocyte-microglia interactions
Gómez-Budia, Mireia; Konttinen, Henna; Saveleva, Liudmila; Korhonen, Paula; Jalava, Pasi; Kanninen, Katja; Malm, Tarja. 2020. Neurochemistry international
Impairment of mitochondrial function by particulate matter: Implications for the brain
Chew, S; Kolosowska, N; Saveleva, L; Malm, T; Kanninen, KM. 2020. Neurochemistry international
Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation
Kolosowska, Natalia; Gotkiewicz, Maria; Dhungana, Hiramani; Giudice, Luca; Giugno, Rosalba; Box, Daphne; Huuskonen, Mikko T.; Korhonen, Paula; Scoyni, Flavia; Kanninen, Katja M.; Ylä-Herttuala, Seppo; Turunen, Tiia A.; Turunen, Mikko P.; Koistinaho, Jari; Malm, Tarja. 2020. Journal of neuroinflammation
Olfactory cell cultures to investigate health effects of air pollution exposure: implications for neurodegeneration
Kanninen, KM; Lampinen, R; Rantanen, LM; Odendaal, L; Jalava, P; Chew, S; White, AR. 2020. Neurochemistry international
Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals
Loppi, Sanna; Korhonen, Paula; Bouvy-Liivrand, Maria; Cagliola, Simone; Turunen, Tiia A; Turunen, Mikko P; Hernandez de Sande, Ana; Kolosowska, Natalia; Scoyni, Flavia; Rosell, Anna; García-Berrocoso, Teresa; Lemarchant, Sighild; Dhungana, Hiramani; Montaner, Joan; Koistinaho, Jari; Kanninen, Katja M; Kaikkonen, Minna U; Giugno, Rosalba; Heinäniemi, Merja; Malm, Tarja. 2020. Aging cell
Proteomic and functional analyses in disease models reveal CLN5 protein involvement in mitochondrial dysfunction
Doccini, S; Morani, F; Nesti, C; Pezzini, F; Calza, G; Soliymani, R; Signore, G; Rocchiccioli, S; Kanninen, KM; Huuskonen, MT; Baumann, MH; Simonati, A; Lalowski, MM; Santorelli, FM. 2020. Cell death discovery
Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells
Chew, Sweelin; Lampinen, Riikka; Saveleva, Liudmila; Korhonen, Paula; Mikhailov, Nikita; Grubman, Alexandra; Polo, Jose M; Wilson, Trevor; Komppula, Mika; Rönkkö, Teemu; Gu, Cheng; Mackay-Sim, Alan; Malm, Tarja; White, Anthony R; Jalava, Pasi; Kanninen, Katja M. 2020. Particle and fibre toxicology
Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis
Korhonen, P; Pollari, E; Kanninen, KM; Savchenko, E; Lehtonen, ¦; Wojciechowski; S; Pomeshchik, Y; Van Den Bosch, L; Goldsteins, G; Koistinaho, J; Malm, T. 2019. IBRO reports
Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice
Singh, Y; Leinonen, H; Fazaludeen, F; Jaronen, M; Guest, D; Buckley, N; Byts, N; Oksa, P; Jalkanen, K; Iqbal, I; Huuskonen, M; Savchenko, E; Keksa-Goldsteine, V; Chew, S; Myllyharju, J; Tanila, H; Ooi, L; Koistinaho, J; Kanninen, KM; Malm, T. 2019. Human molecular genetics
NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes
Oksanen, M; Hyötyläinen, I; Trontti, K; Rolova, T; Wojciechowski, S; Koskuvi, M; Viitanen, M; Levonen, AL; Hovatta, I; Roybon, L; Lehtonen, ¦; Kanninen, KM; Hämäläinen, RH; Koistinaho, J. 2019. Glia
PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia
Konttinen, H; Cabral-da-Silva, MEC; Ohtonen, S; Wojciechowski, S; Shakirzyanova, A; Caligola, S; Giugno, R; Ishchenko, Y; Hernández, D; Fazaludeen, MF; Eamen, S; Budia, MG; Fagerlund, I; Scoyni, F; Korhonen, P; Huber, N; Haapasalo, A; Hewitt, AW; Vickers, J; Smith, GC; et al.. 2019. Stem cell reports
Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes
Gynther, Mikko; Puris, Elena; Peltokangas, Soile; Auriola, Seppo; Kanninen, Katja M; Koistinaho, Jari; Huttunen, Kristiina M; Ruponen, Marika; Vellonen, Kati-Sisko. 2018. Pharmaceutical research
CuII(atsm) Attenuates Neuroinflammation
Choo, Xin Yi; Liddell, Jeffrey R; Huuskonen, Mikko T; Grubman, Alexandra; Moujalled, Diane; Roberts, Jessica; Kysenius, Kai; Patten, Lauren; Quek, Hazel; Oikari, Lotta E; Duncan, Clare; James, Simon A; McInnes, Lachlan E; Hayne, David J; Donnelly, Paul S; Pollari, Eveliina; Vähätalo, Suvi; Lejavová, Katarína; Kettunen, Mikko I; Malm, Tarja; et al. [Incl Koistinaho, Jari; Kanninen, Katja]. 2018. Frontiers in neuroscience
HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage
Loppi, S; Kolosowska, N; Kärkkäinen, O; Korhonen, P; Huuskonen, M; Grubman, A; Dhungana, H; Wojciechowski, S; Pomeshchik, Y; Giordano, M; Kagechika, H; White, A; Auriola, S; Koistinaho, J; Landreth, G; Hanhineva, K; Kanninen, K; Malm, T. 2018. Brain behavior and immunity
Long-term exercise protects against cellular stresses in aged mice
Belaya, Irina; Suwa, Masataka; Chen, Tao; Giniatullin, Rashid; Kanninen, Katja; Atalay, Mustafa; Kumagai, Shuzo. 2018. Oxidative medicine and cellular longevity
Mitochondrial Function in Alzheimer's Disease: Focus on Astrocytes
Lampinen, Riikka; Belaya, Irina; Boccuni, Isabella; Malm, Tarja; Kanninen, Katja M. 2018. InTech Open
PPARß/DELTA-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes
Konttinen, H; Gureviciene, I; Oksanen, M; Grubman, A; Loppi, S; Huuskonen, MT; Korhonen, P; Lampinen, R; Keuters, M; Belaya, I; Tanila, H; Kanninen, KM; Goldsteins, G; Landreth, G; Koistinaho, J; Malm, T. 2018. Glia
Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration
Abdalkader, Moataz; Lampinen, Riikka; Kanninen, Katja M; Malm, Tarja M; Liddell, Jeffrey R. 2018. Frontiers in neuroscience
Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases
Kanninen Katja M, White Anthony R. 2017. Academic press
Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease
Vellonen KS, Ihalainen J, Boucau M-C, Gosselet F, Picardat T, Gynther M, Kanninen KM, White AR, Malm T, Koistinaho J, Forsberg MM, Ruponen M. 2017. Pharmaceutical research
Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy
Nissinen J, Andrade P, Natunen T, Hiltunen M, Malm T, Kanninen K, Soares JI, Shatilloa O, Sallinen J, Ndode-Ekanea XE, Pitkänen A. 2017. Epilepsy research
Lack of collagen XV is protective after ischemic stroke in mice
Dhungana Hiramani, Huuskonen Mikko T, Pihlajaniemi Taina, Heljasvaara Ritva, Vivien Denis, Kanninen Katja M, Malm Tarja, Koistinaho Jari, Lemarchant Sighild. 2017. Cell death and disease
Loss of CLN5 causes altered neurogenesis in a childhood neurodegenerative disorder
Savchenko E, Singh Y, Konttinen H, Lejavova K, Mediavilla Santos L, Grubman A, Kärkkäinen V, Keksa-Goldsteine V, Naumenko N, Tavi P, White AR, Malm TM, Koistinaho J, Kanninen KM. 2017. Disease models and mechanisms
Metals and lysosomal storage disorders
Konttinen Henna, Lejavová Katarína, Malm Tarja, Kanninen Katja M. 2017. Academic press
PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease
Oksanen M, Petersen AJ, Naumenko N, Puttonen K, Lehtonen ¦, Gubert Olivé M, Shakirzyanova A, Leskelä S, Sarajärvi T, Viitanen M, Rinne JO, Hiltunen M, Haapasalo A, Giniatullin R, Tavi P, Zhang SC, Kanninen KM, Hämäläinen RH, Koistinaho J. 2017. Stem cell reports
Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy
Leinonen Henri, Keksa-Goldsteine Velta, Ragauskas Symantas, Kohlmann Philip, Signh Yajuvinder, Savchencko Ekaterina, Puranen Jooseppi, Malm Tarja, Kalesnykas Giedrius, Koistinaho Jari, Tanila Heikki, Kanninen Katja M. 2017. Scientific reports
Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation
Dhungana H, Huuskonen MT, Jaronen M, Lemarchant S, Ali H, Keksa-Goldsteine V, Goldsteins G, Kanninen KM, Koistinaho J, Malm T. 2017. Journal of neuroinflammation
The Copper bis(thiosemicarbazone) Complex Cu(II)(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu
Huuskonen, MT; Tuo, QZ; Loppi, S; Dhungana, H; Korhonen, P; McInnes, LE; Donnelly, PS; Grubman, A; Wojciechowski, S; Lejavova, K; Pomeshchik, Y; Periviita, L; Kosonen, L; Giordano, M; Walker, FR; Liu, R; Bush, AI; Koistinaho, J; Malm, T; White, AR; et al.. 2017. Neurotherapeutics
Type-I interferons in Parkinson's disease: innate inflammatory response drives fate of neurons in model of degenerative brain disorder: An editorial comment on 'Type-I interferons mediate the neuroinflammatory response and neurotoxicity induced by rotenone'
Kanninen KM, White AR. 2017. Journal of neurochemistry
ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. 2016. Molecular neurodegeneration
Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke
Lemarchant S, Dunghana H, Pomeshchik Y, Leinonen H, Kolosowska N, Korhonen P, Kanninen KM, García-Berrocoso T, Montaner J, Malm T, Koistinaho J. 2016. Glia
Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy
Huuskonen MT, Loppi S, Dhungana H, Keksa-Goldsteine V, Lemarchant S, Korhonen P, Wojciechowski S, Pollari E, Valonen P, Koponen J, Takashima A, Landreth G, Goldsteins G, Malm T, Koistinaho J, Kanninen KM. 2016. Scientific reports
Eksosomit aivosairauksissa - solujenvälisen kommunikoinnin uusi muoto
Kanninen K, Malm T. 2016. Duodecim
Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. 2016. Molecular neurodegeneration
Exosomes in Alzheimer's disease
Malm Tarja, Loppi Sanna, Kanninen Katja M. 2016. Neurochemistry international
Multitasking Microglia and Alzheimer's Disease: Diversity, Tools and Therapeutic Targets
Grubman Alexandra, Kanninen Katja M, Malm Tarja. 2016. Journal of molecular neuroscience
Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes
Liddell Jeffrey R, Lehtonen Sarka, Duncan Clare, Keksa-Goldsteine Velta, Levonen Anna-Liisa, Goldsteins Gundars, Malm Tarja, White Anthony R, Koistinaho Jari, Kanninen Katja M. 2016. Journal of neuroinflammation
Applications of the Keap1-Nrf2 system for gene and cell therapy
Kanninen Katja M, Pomeshchik Yuriy, Leinonen Hanna, Malm Tarja, Koistinaho Jari, Levonen Anna-Liisa. 2015. Free radical biology and medicine
Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage
Rolova Taisia, Dhungana Hiramani, Korhonen Paula, Valonen Piia, Kolosowska Natalia, Konttinen Henna, Kanninen Katja, Tanila Heikki, Malm Tarja, Koistinaho Jari. 2015. Aging and disease
Editorial: Metals and neurodegeneration: restoring the balance
White Anthony R, Kanninen Katja M, Crouch Peter J. 2015. Frontiers in aging neuroscience
Exosomes as new diagnostic tools in CNS diseases
Kanninen Katja M, Bister Nea, Koistinaho Jari, Malm Tarja. 2015. Biochimica et biophysica acta: molecular basis of disease
Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation
Korhonen Paula, Kanninen Katja M, Lehtonen Sarka, Lemarchant Sighild, Puttonen Katja A, Oksanen Minna, Dhungana Hiramani, Loppi Sanna, Pollari Eveliina, Wojciechowski Sara, Kidin Iurii, Garcia-Berrocoso Teresa, Giralt Dolors, Montaner Joan, Koistinaho Jan I, Malm Tarja. 2015. Brain behavior and immunity
Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?
Grubman Alexandra, Pollari Eveliina, Duncan Clare, Caragounis Aphrodite, Blom Tea, Volitakis Irene, Wong Andrew, Cooper Jonathan, Crouch Peter J, Koistinaho Jari, Jalanko Anu, White Anthony R, Kanninen Katja M. 2014. Metallomics
Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder
Grubman Alexandra, Lidgerwood Grace E, Duncan Clare, Bica Laura, Tan Jiang-Li, Parker Sarah J, Caragounis Aphrodite, Meyerowitz Jodi, Volitakis Irene, Moujalled Diane, Liddell Jeffrey R, Hickey James L, Horne Malcolm, Longmuir Shoshanah, Koistinaho Jari, Donnelly Paul S, Crouch Peter J, Tammen Imke, White Anthony R, Kanninen Katja M. 2014. Acta neuropathologica communications
Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury
Pomeshchik Y, Kidin I, Korhonen P, Savchenko E, Jaronen M, Lehtonen S, Wojciechowski S, Kanninen K, Koistinaho J, Malm T. 2014. Brain behavior and immunity
Nrf2 regulates neurogenesis and protects neural progenitor cells against aß toxicity
Kärkkäinen Virve, Pomeshchik Yuriy, Savchenko Ekaterina, Dhungana Hiramani, Kurronen Antti, Lehtonen Sarka, Naumenko Nikolay, Tavi Pasi, Levonen Anna-Liisa, Yamamoto Masayaki, Malm Tarja, Magga Johanna, Kanninen Katja M, Koistinaho Jari. 2014. Stem cells
Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis
Roberts Blaine R, Lim Nastasia KH, McAllum Erin J, Donnelly Paul S, Hare Dominic J, Doble Philip A, Turner Bradley J, Price Katherine A, Lim Sin Chun, Paterson Brett M, Hickey James L, Rhoads Timothy W, Williams Jared R, Kanninen Katja M, Hung Lin W, Liddell Jeffrey R, Grubman Alexandra, Monty Jean-Francois, Llanos Roxana M, Kramer David R, Mercer Julian FB, Bush Ashley I, Masters Colin L, Duce James A, Li Qiao-Xin, Beckman Joseph S, Barnham Kevin J, White Anthony R, Crouch Peter J. 2014. Journal of neuroscience
Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43
Moujalled Diane, James Janine L, Yang Shu, Zhang Katharine, Duncan Clare, Moujalled Donia M, Parker Sarah J, Caragounis Aphrodite, Lidgerwood Grace, Turner Bradley J, Atkin Julie D, Grubman Alexandra, Liddell Jeffrey R, Proepper Christian, Boeckers Tobias M, Kanninen Katja M, Blair Ian, Crouch Peter J, White Anthony R. 2014. Human molecular genetics
X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder
Grubman A, James SA, James J, Duncan C, Volitakis I, Hickey JL, Crouch PJ, Donnelly PS, Kanninen KM, Liddell JR, Cotman SL, de Jonge MD, White AR. 2014. Chemical science
ADAMTS proteoglycanases in the physiological and pathological central nervous system
Lemarchant S, Pruvost M, Montaner J, Emery E, Vivien D, Kanninen K, Koistinaho J. 2013. Journal of neuroinflammation
Biometals in rare neurodegenerative disorders of childhood
Parker SJ, Koistinaho J, White AR, Kanninen KM. 2013. Frontiers in aging neuroscience
Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit
Rolova T, Puli L, Magga J, Dhungana H, Kanninen K, Wojciehowski S, Salminen A, Tanila H, Koistinaho J, Malm T. 2013. Neurobiology of disease
Does Nrf2 Gene Transfer Facilitate Recovery After Contusion Spinal Cord Injury?
Pomeshchik Y, Kidin I, Savchenko E, Rolova T, Yamamoto M, Levonen AL, Ylä-Herttuala S, Malm T, Kanninen K, Koistinaho J. 2013. Antioxidants and redox signaling
Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis
Kanninen KM, Grubman A, Meyerowitz J, Duncan C, Tan JL, Parker SJ, Crouch PJ, Paterson BM, Hickey JL, Donnelly PS, Volitakis I, Tammen I, Palmer DN, White AR. 2013. PLoS ONE
Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress
Moujalled D, James JL, Parker SJ, Lidgerwood GE, Duncan C, Meyerowitz J, Nonaka T, Hasegawa M, Kanninen KM, Grubman A, Liddell JR, Crouch PJ, White AR. 2013. PLoS ONE
Adult and neonatal astrocytes exhibit diverse gene expression profiles in response to beta amyloid ex vivo
Kurronen A, Pihlaja R, Pollari E, Kanninen K, Storvik M, Wong G, Koistinaho M, Koistinaho J. 2012. World journal of neuroscience
Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis
Pollari Eveliina, Savchenko Ekaterina, Jaronen Merja, Kanninen Katja, Malm Tarja, Wojciechowski Sara, Ahtoniemi Toni, Goldsteins Gundars, Giniatullina Raisa, Giniatullin Rashid, Koistinaho Jari, Magga Johanna. 2011. Journal of neuroinflammation
Targeting Glycogen Synthase Kinase-3&#946 for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway
Kanninen K, White AR, Koistinaho J, Malm T. 2011. International journal of alzheimers disease
Utilization of APPswe/PS1dE9 Transgenic Mice in Research of Alzheimer's Disease: Focus on Gene Therapy and Cell-Based Therapy Applications
Malm T, Koistinaho J, Kanninen K. 2011. International journal of alzheimers disease
Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease
Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J. 2009. Proceedings of the National Academy of Sciences of the United States of America
Nrf2 in Alzheimer's Disease
Kanninen K. 2009. Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti
Nuclear factor erythroid 2-related factor 2 protects against beta amyloid
Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL, Koistinaho J. 2008. Molecular and cellular neuroscience
Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden
Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, van Groen T, Tanila H, Koistinaho J. 2007. Journal of neuroscience
Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis
Ahtoniemi T, Goldsteins G, Keksa-Goldsteine V, Malm T, Kanninen K, Salminen A, Koistinaho J. 2007. Molecular pharmacology
Beta-amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits
Malm T, Ort M, Tähtivaara L, Jukarainen N, Goldsteins G, Puoliväli J, Nurmi A, Pussinen R, Ahtoniemi T, Miettinen T-K, Kanninen K, Leskinen S, Vartiainen N, Yrjänheikki J, Laatikainen R, Harris-White ME, Koistinaho M, Frautschy SA, Bures J. 2006. Proceedings of the National Academy of Sciences of the United States of America
The Eleventh Annual Post-Graduate Symposium of the A.I. Virtanen Institute Graduate School. AIVI Winter School 2006. Abstracts
Keinänen R, Huttunen J, Häkkinen S-K, Kanninen K, Lipponen A, Louhivuori L, Mäkelä K, Mäntylä T, Tusa M. 2006. Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti
Glycosylation changes in Alzheimer's disease as revealed by a proteomic approach
Kanninen K, Goldsteins G, Auriola S, Alafuzoff I, Koistinaho J. 2004. Neuroscience letters

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Tekninen tallennus tai pääsy on tarpeen laillisessa tarkoituksessa sellaisten asetusten tallentamiseen, joita tilaaja tai käyttäjä ei ole pyytänyt.

Tilastot Tilastot

Tekninen tallennus tai pääsy, jota käytetään yksinomaan tilastollisiin tarkoituksiin. Tekninen tallennus tai pääsy, jota käytetään yksinomaan anonyymeihin tilastollisiin tarkoituksiin. Ilman haastetta, Internet-palveluntarjoajasi vapaaehtoista suostumusta tai kolmannen osapuolen lisätietueita pelkästään tähän tarkoitukseen tallennettuja tai haettuja tietoja ei yleensä voida käyttää tunnistamaan sinua.

Markkinointi Markkinointi

Teknistä tallennustilaa tai pääsyä tarvitaan käyttäjäprofiilien luomiseen mainosten lähettämistä varten tai käyttäjän seuraamiseksi verkkosivustolla tai useilla verkkosivustoilla vastaavia markkinointitarkoituksia varten.

Näytä asetukset

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Tarkenna hakuasi

Katja Kanninen

Tutkimusryhmät

Projektit

Avainsanat

Importance of sub-23 nm particles in traffic environments: Particle number emission factors and extrathoracic deposition doses

A technological comparison of freeze-dried poly-ɛ-caprolactone (PCL) and poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with clozapine for nose-to-brain delivery

Adverse outcome pathway for the neurotoxicity of Per- and polyfluoroalkyl substances: A systematic review

Blood cytokines in major depressive disorder in drug-naïve adolescents: A systematic review and meta-analysis

Circular RNA circ_0061183 regulates microglial polarization induced by airborne ultrafine particles in HMC3 cells via sponging miR-98-5p

Exposure to source-specific air pollution in residential areas and its association with dementia incidence: a cohort study in Northern Sweden

Exposure to urban particulate matter alters responses of olfactory mucosal cells to SARS-CoV-2 infection

Increased Expression of Transferrin Receptor 1 in the Brain Cortex of 5xFAD Mouse Model of Alzheimer’s Disease Is Associated with Activation of HIF-1 Signaling Pathway

Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles

Long-term exposure to major constituents of fine particulate matter and neurodegenerative diseases: A population-based survey in the Pearl River Delta Region, China

Metabolic profiles associated with exposure to ambient particulate air pollution: findings from the Betula cohort

Neurotoxicity of fine and ultrafine particulate matter: A comprehensive review using a toxicity pathway-oriented adverse outcome pathway framework

Particulate matter from car exhaust alters function of human iPSC-derived microglia

Proteomic insights into mental health status: plasma markers in young adults

Sex-specific changes in protein expression of membrane transporters in the brain cortex of 5xFAD mouse model of Alzheimer’s disease

The association between oral diseases and neurodegenerative disorders

The emerging roles of particulate matter-changed non-coding RNAs in the pathogenesis of Alzheimer's disease: A comprehensive in silico analysis and review

Traffic-related ultrafine particles impair mitochondrial functions in human olfactory mucosa cells – Implications for Alzheimer's disease

Transcriptomic and epigenomic profiling reveals altered responses to diesel emissions in Alzheimer's disease both in vitro and in population-based data

Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse model

Adopting a child perspective for exposome research on mental health and cognitive development - Conceptualisation and opportunities

Dynamic release of neuronal extracellular vesicles containing miR‐21a‐5p is induced by hypoxia

Emissions from modern engines induce distinct effects in human olfactory mucosa cells, depending on fuel and aftertreatment

Exploring plasma biomarker candidates for mental health risk assessment in adolescents

Human-derived air–liquid interface cultures decipher Alzheimer’s disease–SARS-CoV-2 crosstalk in the olfactory mucosa

Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins

Plasma proteomics discovery of mental health risk biomarkers in adolescents

Protective effect of restorative possibilities on cognitive function and mental health in children and adolescents: A scoping review including the role of physical activity

The Interaction between Circulating Cell-Free Mitochondrial DNA and Inflammatory Cytokines in Predicting Human Mental Health Issue Risk in Adolescents: An Explorative Study

Transcriptomic Alterations in the Olfactory Bulb Induced by Exposure to Air Pollution: Identification of Potential Biomarkers and Insights into Olfactory System Function

9th Kuopio Alzheimer Symposium and 3rd Nordic Memory Clinic Conference: Program and Abstracts

Air Pollution Exposure Increases ABCB1 and ASCT1 Transporter Levels in Mouse Cortex

An Alzheimer’s Disease Patient-Derived Olfactory Stem Cell Model Identifies Gene Expression Changes Associated with Cognition

Biometal Dyshomeostasis in Olfactory Mucosa of Alzheimer’s Disease Patients

Early environmental quality and life-course mental health effects: The Equal-Life project

Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease

Lysosomal Proteomics Links Disturbances in Lipid Homeostasis and Sphingolipid Metabolism to CLN5 Disease

Mechanistic Understanding of the Olfactory Neuroepithelium Involvement Leading to Short-Term Anosmia in COVID-19 Using the Adverse Outcome Pathway Framework

Metabolomic, Lipidomic and Proteomic Characterisation of Lipopolysaccharide-induced Inflammation Mouse Model

Microglial amyloid beta clearance is driven by PIEZO1 channels

Neuron-astrocyte transmitophagy is altered in Alzheimer's disease

Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex

Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer’s Disease

Single-Cell RNA-Seq Analysis of Olfactory Mucosal Cells of Alzheimer’s Disease Patients

Subacute inhalation of ultrafine particulate matter triggers inflammation without altering amyloid beta load in 5xFAD mice

Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice

TUBE Project: Transport-Derived Ultrafines and the Brain Effects

The Adverse Outcome Pathway Framework Applied to Neurological Symptoms of COVID-19

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo

Increased iron content in the heart of the Fmr1 knockout mouse

Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice

Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer's Disease

Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease

Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy

Editorial: Air Pollution and Brain Health

Glial smog: Interplay between air pollution and astrocyte-microglia interactions

Impairment of mitochondrial function by particulate matter: Implications for the brain

Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation

Olfactory cell cultures to investigate health effects of air pollution exposure: implications for neurodegeneration

Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals

Proteomic and functional analyses in disease models reveal CLN5 protein involvement in mitochondrial dysfunction

Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis

Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice

NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes

CuII(atsm) Attenuates Neuroinflammation

HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage

Long-term exercise protects against cellular stresses in aged mice

Mitochondrial Function in Alzheimer's Disease: Focus on Astrocytes

PPARß/DELTA-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration

Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases