Katja Kanninen
Professor
Professor
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
[email protected] | +358 46 921 0065
I lead the Cellular Neurobiology research group at the A.I.Virtanen Institute for Molecular Sciences where I work as a professor. Our research interest is centered on how environmental factors and agents such as air pollutants and viral infections affect brain health. We also study Alzheimer’s disease with patient-derived cells.
More information on the research group found at: https://uefconnect.uef.fi/en/group/cellular-neurobiology/#information
Research groups
Projects
Publications
124/124 items-
Importance of sub-23 nm particles in traffic environments: Particle number emission factors and extrathoracic deposition doses
Lintusaari, Henna; Lepistö, Teemu; Saarikoski, Sanna; Salo, Laura; Silvonen, Ville; Barreira, Luis M.F.; Aurela, Minna; Hoivala, Jussi; Markkula, Lassi; Ondracek, Jakub; Wahle, Tina; Vojtisek-Lom, Michal; Topinka, Jan; Schins, Roel PF; Jalava, Pasi; Timonen, Hilkka; Kanninen, Katja M; Rönkkö, Topi. 2025. Environmental pollution. 369: A1 Journal article (refereed), original research -
Traffic-related ultrafine particles influence gene regulation in olfactory mucosa cells altering PI3K/AKT signaling
Mussalo, Laura; Afonin, Alexey M.; Zavodna, Tana; Krejcik, Zdenek; Honkova, Katerina; Fayad, Claire; Shahbaz, Muhammad Ali; Kalapudas, Juho; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Malm, Tarja; Topinka, Jan; Jalava, Pasi; Lampinen, Riikka; Kanninen, Katja M. 2025. Environment international. 199: A1 Journal article (refereed), original research -
A technological comparison of freeze-dried poly-ɛ-caprolactone (PCL) and poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with clozapine for nose-to-brain delivery
Lombardo, Rosamaria; Ruponen, Marika; Rautio, Jarkko; Lampinen, Riikka; Kanninen, Katja M.; Koivisto, Anne M.; Penttilä, Elina; Löppönen, Heikki; Demartis, Sara; Giunchedi, Paolo; Rassu, Giovanna; Fragalà, Maria Elena; Pignatello, Rosario. 2024. Journal of drug delivery science and technology. 93: . 105419 A1 Journal article (refereed), original research -
Adverse outcome pathway for the neurotoxicity of Per- and polyfluoroalkyl substances: A systematic review
Li, Shenpan; Qin, Shuangjian; Zeng, Huixian; Chou, Weichun; Oudin, Anna; Kanninen, Katja M.; Jalava, Pasi; Dong, Guanghui; Zeng, Xiaowen. 2024. Eco-environment & health. 3: 476-493 A2 Review article, Literature review, Systematic review -
Blood cytokines in major depressive disorder in drug-naïve adolescents: A systematic review and meta-analysis
Jadhav, Kaustubh Kishor; Daouk, Joud; Kurkinen, Karoliina; Kraav, Siiri-Liisi; Eriksson, Päivi; Tolmunen, Tommi; Kanninen, Katja M. 2024. Journal of affective disorders. 2025; 372: 48-55 A2 Review article, Literature review, Systematic review -
Circular RNA circ_0061183 regulates microglial polarization induced by airborne ultrafine particles in HMC3 cells via sponging miR-98-5p
Zeng, Hui-Xian; Qin, Shuang-Jian; Wu, Qi-Zhen; Zeng, Qing-Guo; Li, Jia-Hui; Oudin, Anna; Kanninen, Katja M.; Yang, Mo; Jalava, Pasi; Dong, Guang-Hui; Zeng, Xiao-Wen. 2024. Journal of hazardous materials. 2025; 484: A1 Journal article (refereed), original research -
Exposure to source-specific air pollution in residential areas and its association with dementia incidence: a cohort study in Northern Sweden
Oudin, Anna; Raza, Wasif; Flanagan, Erin; Segersson, David; Jalava, Pasi; Kanninen, Katja M.; Rönkkö, Topi; Giugno, Rosalba; Sandström, Thomas; Muala, Ala; Topinka, Jan; Sommar, Johan. 2024. Scientific reports. 14: . 15521 A1 Journal article (refereed), original research -
Exposure to urban particulate matter alters responses of olfactory mucosal cells to SARS-CoV-2 infection
Shahbaz, Muhammad Ali; Kuivanen, Suvi; Mussalo, Laura; Afonin, Alexey M; Kumari, Kajal; Behzadpour, Donya; Kalapudas, Juho; Koivisto, Anne M; Penttilä, Elina; Löppönen, Heikki; Jalava, Pasi; Vapalahti, Olli; Balistreri, Giuseppe; Lampinen, Riikka; Kanninen, Katja M. 2024. Environmental research. 249: A1 Journal article (refereed), original research -
Increased Expression of Transferrin Receptor 1 in the Brain Cortex of 5xFAD Mouse Model of Alzheimer’s Disease Is Associated with Activation of HIF-1 Signaling Pathway
Petralla, Sabrina; Saveleva, Liudmila; Kanninen, Katja M; Oster, Julia S; Panayotova, Maria; Fricker, Gert; Puris, Elena. 2024. Molecular neurobiology. 61: 6383-6394 A1 Journal article (refereed), original research -
Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles
Drouard, Gabin; Wang, Zhiyang; Heikkinen, Aino; Foraster, Maria; Julvez, Jordi; Kanninen, Katja M.; van Kamp, Irene; Pirinen, Matti; Ollikainen, Miina; Kaprio, Jaakko. 2024. Scientific reports. 14: A1 Journal article (refereed), original research -
Long-term exposure to major constituents of fine particulate matter and neurodegenerative diseases: A population-based survey in the Pearl River Delta Region, China
Wu, Qi-Zhen; Zeng, Hui-Xian; Andersson, John; Oudin, Anna; Kanninen, Katja M.; Xu, Mu-Wu; Qin, Shuang-Jian; Zeng, Qing-Guo; Zhao, Bin; Zheng, Mei; Jin, Nanxiang; Chou, Wei-Chun; Jalava, Pasi; Dong, Guang-Hui; Zeng, Xiao-Wen. 2024. Journal of hazardous materials. 470: A1 Journal article (refereed), original research -
Metabolic profiles associated with exposure to ambient particulate air pollution: findings from the Betula cohort
Raza, Wasif; Öhman, Anders; Kanninen, Katja M; Jalava, Pasi; Zeng, Xiao-wen; de Crom, Tosca OE; Ikram, M Arfan; Oudin, Anna. 2024. Frontiers in public health. 12: . 1401006 A1 Journal article (refereed), original research -
Neurotoxicity of fine and ultrafine particulate matter: A comprehensive review using a toxicity pathway-oriented adverse outcome pathway framework
Qin, Shuang-Jian; Zeng, Qing-Guo; Zeng, Hui-Xian; Li, Shen-Pan; Andersson, John; Zhao, Bin; Oudin, Anna; Kanninen, Katja M; Jalava, Pasi; Jin, Nan-Xiang; Yang, Mo; Lin, Li-Zi; Liu, Ru-Qing; Dong, Guang-Hui; Zeng, Xiao-Wen. 2024. Science of the total environment. 947: A2 Review article, Literature review, Systematic review -
Particulate matter from car exhaust alters function of human iPSC-derived microglia
Jäntti, Henna; Jonk, Steffi; Gómez Budia, Mireia; Ohtonen, Sohvi; Fagerlund, Ilkka; Fazaludeen, Mohammad Feroze; Aakko-Saksa, Päivi; Pebay, Alice; Lehtonen, Šárka; Koistinaho, Jari; Kanninen, Katja M; Jalava, Pasi I; Malm, Tarja; Korhonen, Paula. 2024. Particle and fibre toxicology. 21: . 6 A1 Journal article (refereed), original research -
Proteomic insights into mental health status: plasma markers in young adults
Afonin, Alexey M; Piironen, Aino-Kaisa; de Sousa Maciel, Izaque; Ivanova, Mariia; Alatalo, Arto; Whipp, Alyce M; Pulkkinen, Lea; Rose, Richard J; van Kamp, Irene; Kaprio, Jaakko; Kanninen, Katja M. 2024. Translational psychiatry. 14: . 55 A1 Journal article (refereed), original research -
Sex-specific changes in protein expression of membrane transporters in the brain cortex of 5xFAD mouse model of Alzheimer’s disease
Puris, Elena; Saveleva, Liudmila; Auriola, Seppo; Gynther, Mikko; Kanninen, Katja M; Fricker, Gert. 2024. Frontiers in pharmacology. 15: . 1365051 A1 Journal article (refereed), original research -
The association between oral diseases and neurodegenerative disorders
Soiniemi, Lauriina; Solje, Eino; Suominen, Anna Liisa; Kanninen, Katja M; Kullaa, Arja M. 2024. Journal of Alzheimer's disease. 102: 577-586 A2 Review article, Literature review, Systematic review -
The emerging roles of particulate matter-changed non-coding RNAs in the pathogenesis of Alzheimer's disease: A comprehensive in silico analysis and review
Zeng, Hui-Xian; Qin, Shuang-Jian; Andersson, John; Li, Shen-Pan; Zeng, Qing-Guo; Li, Jia-Hui; Wu, Qi-Zhen; Meng, Wen-Jie; Oudin, Anna; Kanninen, Katja M.; Jalava, Pasi; Dong, Guang-Hui; Zeng, Xiao-Wen. 2024. Environmental pollution. 2025; 366: A2 Review article, Literature review, Systematic review -
Traffic-related ultrafine particles impair mitochondrial functions in human olfactory mucosa cells – Implications for Alzheimer's disease
Mussalo, Laura; Lampinen, Riikka; Avesani, Simone; Závodná, Táňa; Krejčík, Zdeněk; Kalapudas, Juho; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Malm, Tarja; Topinka, Jan; Giugno, Rosalba; Jalava, Pasi; Kanninen, Katja M. 2024. Redox biology. 75: A1 Journal article (refereed), original research -
Transcriptomic and epigenomic profiling reveals altered responses to diesel emissions in Alzheimer's disease both in vitro and in population-based data
Saveleva, Liudmila; Cervena, Tereza; Mengoni, Claudia; Sima, Michal; Krejcik, Zdenek; Vrbova, Kristyna; Sikorova, Jitka; Mussalo, Laura; de Crom, Tosca O E; Šímová, Zuzana; Ivanova, Mariia; Shahbaz, Muhammad Ali; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Ikram, M Arfan; Jalava, Pasi I; Malm, Tarja; Chew, Sweelin; Vojtisek‐Lom, Michal; Topinka, Jan; Giugno, Rosalba; Rössner, Pavel; Kanninen, Katja M. 2024. Alzheimer's & dementia. 20: 8825-8843 A1 Journal article (refereed), original research -
Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse model
Ivanova, Mariia; Belaya, Irina; Kucháriková, Nina; de Sousa Maciel, Izaque; Saveleva, Liudmila; Alatalo, Arto; Juvonen, Ilona; Thind, Navjot; Andrès, Clarisse; Lampinen, Riikka; Chew, Sweelin; Kanninen, Katja M. 2024. Neurobiology of disease. 191: A1 Journal article (refereed), original research -
Adopting a child perspective for exposome research on mental health and cognitive development - Conceptualisation and opportunities
Person Waye, Kerstin; Löve, Jesper; Lercher, Peter; Dzhambov, Angel M.; Klatte, Maria; Schreckenberg, Dirk; Belke, Christin; Leist, Larisa; Ristovska, Gordana; Jeram, Sonja; Kanninen, Katja M.; Selander, Jenny; Arat, Arzu; Lachmann, Thomas; Clark, Charlotte; Botteldooren, Dick; White, Kim; Julvez, Jordi; Foraster, Maria; Kaprio, Jaakko; Bolte, Gabriele; Psyllidis, Achilleas; Gulliver, John; Boshuizen, Hendriek; Bozzon, Alessandro; Fels, Janina; Hornikx, Maarten; van den Hazel, Peter; Weber, Miri. 2023. Environmental research. 239: A1 Journal article (refereed), original research -
Dynamic release of neuronal extracellular vesicles containing miR‐21a‐5p is induced by hypoxia
Korvenlaita, Nea; Gómez‐Budia, Mireia; Scoyni, Flavia; Pistono, Cristiana; Giudice, Luca; Eamen, Shaila; Loppi, Sanna; de Sande, Ana Hernández; Huremagic, Benjamin; Bouvy‐Liivrand, Maria; Heinäniemi, Merja; Kaikkonen, Minna U.; Cheng, Lesley; Hill, Andrew F.; Kanninen, Katja M.; Jenster, Guido W.; van Royen, Martin E.; Ramiro, Laura; Montaner, Joan; Batkova, Tereza; Mikulik, Robert; Giugno, Rosalba; Jolkkonen, Jukka; Korhonen, Paula; Malm, Tarja. 2023. Journal of extracellular vesicles. 12: A1 Journal article (refereed), original research -
Emissions from modern engines induce distinct effects in human olfactory mucosa cells, depending on fuel and aftertreatment
Mussalo, Laura; Avesani, Simone; Shahbaz, Muhammad Ali; Zavodna, Tana; Saveleva, Liudmila; Järvinen, Anssi; Lampinen, Riikka; Belaya, Irina; Krejcik, Zdenek; Ivanova, Mariia; Hakkarainen, Henri; Kalapudas, Juho; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Malm, Tarja; Topinka, Jan; Giugno, Rosalba; Aakko-Saksa, Päivi; Chew, Sweelin; Rönkkö, Topi; Jalava, Pasi; Kanninen, Katja M. 2023. Science of the total environment. 905: A1 Journal article (refereed), original research -
Exploring plasma biomarker candidates for mental health risk assessment in adolescents
Piironen, Aino-Kaisa; Kanninen, Katja. 2023. Nature mental health. 1: 532-533 B1 Non-refereed journal articles -
Human-derived air–liquid interface cultures decipher Alzheimer’s disease–SARS-CoV-2 crosstalk in the olfactory mucosa
Shahbaz, Muhammad Ali; Kuivanen, Suvi; Lampinen, Riikka; Mussalo, Laura; Hron, Tomáš; Závodná, Táňa; Ojha, Ravi; Krejčík, Zdeněk; Saveleva, Liudmila; Tahir, Numan Ahmad; Kalapudas, Juho; Koivisto, Anne M; Penttilä, Elina; Löppönen, Heikki; Singh, Prateek; Topinka, Jan; Vapalahti, Olli; Chew, Sweelin; Balistreri, Giuseppe; Kanninen, Katja M. 2023. Journal of neuroinflammation. 20: . 299 A1 Journal article (refereed), original research -
Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins
Drouard, Gabin; Hagenbeek, Fiona A; Whipp, Alyce M.; Pool, René; Hottenga, Jouke Jan; Jansen, Rick; Hubers, Nikki; Afonin, Aleksei; Willemsen, Gonneke; de Geus, Eco JC; Ripatti, Samuli; Pirinen, Matti; Kanninen, Katja M; Boomsma, Dorret I; van Dongen, Jenny; Kaprio, Jaakko. 2023. Bmc medicine. 21: . 508 A1 Journal article (refereed), original research -
Plasma proteomics discovery of mental health risk biomarkers in adolescents
de Sousa Maciel, Izaque; Piironen, Aino-Kaisa; Afonin, Alexey M; Ivanova, Mariia; Alatalo, Arto; Jadhav, Kaustubh Kishor; Julvez, Jordi; Foraster, Maria; van Kamp, Irene; Kanninen, Katja M. 2023. Nature mental health. 1: 596-605 A1 Journal article (refereed), original research -
Protective effect of restorative possibilities on cognitive function and mental health in children and adolescents: A scoping review including the role of physical activity
Dzhambov, Angel M; Lercher, Peter; Vincens, Natalia; Persson Waye, Kerstin; Klatte, Maria; Leist, Larisa; Lachmann, Thomas; Schreckenberg, Dirk; Belke, Christin; Ristovska, Gordana; Kanninen, Katja M; Botteldooren, Dick; Van Renterghem, Timothy; Jeram, Sonja; Selander, Jenny; Arat, Arzu; White, Kim; Julvez, Jordi; Clark, Charlotte; Foraster, Maria; van Kamp, Irene. 2023. Environmental research. 233: . 116452 A1 Journal article (refereed), original research -
The Interaction between Circulating Cell-Free Mitochondrial DNA and Inflammatory Cytokines in Predicting Human Mental Health Issue Risk in Adolescents: An Explorative Study
Alatalo, Arto; de Sousa Maciel, Izaque; Kucháriková, Nina; Chew, Sweelin; van Kamp, Irene; Foraster, Maria; Julvez, Jordi; Kanninen, Katja M. 2023. Biomedicines. 11: A1 Journal article (refereed), original research -
Transcriptomic Alterations in the Olfactory Bulb Induced by Exposure to Air Pollution: Identification of Potential Biomarkers and Insights into Olfactory System Function
Saveleva, Liudmila; Sima, Michal; Klema, Jiri; Krejčík, Zdeněk; Vartiainen, Petra; Sitnikova, Valeriia; Belaya, Irina; Malm, Tarja; Jalava, Pasi I; Rössner, Pavel; Kanninen, Katja M. 2023. Environmental toxicology and pharmacology. 104: A1 Journal article (refereed), original research -
9th Kuopio Alzheimer Symposium and 3rd Nordic Memory Clinic Conference: Program and Abstracts
Kanninen, Katja; Górová, Veronika. 2022. Publications of the University of Eastern Finland. Reports and studies in health sciences. . Itä-Suomen yliopisto D6 Edited professional book -
Air Pollution Exposure Increases ABCB1 and ASCT1 Transporter Levels in Mouse Cortex
Puris, Elena; Saveleva, Liudmila; Górová, Veronika; Vartiainen, Petra; Kortelainen, Miika; Lamberg, Heikki; Sippula, Olli; Malm, Tarja; Jalava, Pasi I; Auriola, Seppo; Fricker, Gert; Kanninen, Katja M. 2022. Environmental toxicology and pharmacology. 96: A1 Journal article (refereed), original research -
An Alzheimer’s Disease Patient-Derived Olfactory Stem Cell Model Identifies Gene Expression Changes Associated with Cognition
Rantanen, Laura M.; Bitar, Maina; Lampinen, Riikka; Stewart, Romal; Quek, Hazel; Oikari, Lotta E.; Cunί-Lόpez, Carla; Sutharsan, Ratneswary; Thillaiyampalam, Gayathri; Iqbal, Jamila; Russell, Daniel; Penttilä, Elina; Löppönen, Heikki; Lehtola, Juha-Matti; Saari, Toni; Hannonen, Sanna; Koivisto, Anne M.; Haupt, Larisa M.; Mackay-Sim, Alan; Cristino, Alexandre S.; Kanninen, Katja M.; White, Anthony R.. 2022. Cells. 11: A1 Journal article (refereed), original research -
Biometal Dyshomeostasis in Olfactory Mucosa of Alzheimer’s Disease Patients
Lampinen, Riikka; Górová, Veronika; Avesani, Simone; Liddell, Jeffrey R; Penttilä, Elina; Závodná, Táňa; Krejčík, Zdeněk; Lehtola, Juha-Matti; Saari, Toni; Kalapudas, Juho; Hannonen, Sanna; Löppönen, Heikki; Topinka, Jan; Koivisto, Anne M; White, Anthony R; Giugno, Rosalba; Kanninen, Katja M. 2022. International journal of molecular sciences. 23: A1 Journal article (refereed), original research -
Early environmental quality and life-course mental health effects: The Equal-Life project
Kamp, Irene van; Persson Waye, Kerstin; Kanninen, Katja; Gulliver, John; Bozzon, Alessandro; Psyllidis, Achilleas; Boshuizen, Hendriek; Selander, Jenny; van den Hazel, Peter; Brambilla, Marco; Foraster, Maria; Julvez, Jordi; Klatte, Maria; Jeram, Sonja; Lercher, Peter; Botteldooren, Dick; Ristovska, Gordana; Kaprio, Jaakko; Schreckenberg, Dirk; Hornikx, Maarten; Fels, Janina; Weber, Miriam; Braat-Eggen, Ella; Hartmann, Julia; Clark, Charlotte; Vrijkotte, Tanja; Brown, Lex; Bolte, Gabriele; Equal. 2022. Environmental epidemiology. 6: A1 Journal article (refereed), original research -
Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease
Gynther, Mikko; Estrada, Mariana Leal; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Auriola, Seppo; Fricker, Gert; Puris, Elena. 2022. Pharmaceutics. 14: A1 Journal article (refereed), original research -
Lysosomal Proteomics Links Disturbances in Lipid Homeostasis and Sphingolipid Metabolism to CLN5 Disease
Doccini, Stefano; Marchese, Maria; Morani, Federica; Gammaldi, Nicola; Mero, Serena; Pezzini, Francesco; Soliymani, Rabah; Santi, Melissa; Signore, Giovanni; Ogi, Asahi; Rocchiccioli, Silvia; Kanninen, Katja M.; Simonati, Alessandro; Lalowski, Maciej M.; Santorelli, Filippo M.. 2022. Cells. 11: A1 Journal article (refereed), original research -
Mechanistic Understanding of the Olfactory Neuroepithelium Involvement Leading to Short-Term Anosmia in COVID-19 Using the Adverse Outcome Pathway Framework
Shahbaz, Muhammad Ali; De Bernardi, Francesca; Alatalo, Arto; Sachana, Magdalini; Clerbaux, Laure-Alix; Muñoz, Amalia; Parvatam, Surat; Landesmann, Brigitte; Kanninen, Katja M.; Coecke, Sandra. 2022. Cells. 11: A1 Journal article (refereed), original research -
Metabolomic, Lipidomic and Proteomic Characterisation of Lipopolysaccharide-induced Inflammation Mouse Model
Puris, Elena; Kouřil, Štěpán; Najdekr, Lukáš; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Gómez-Budia, Mireia; Fricker, Gert; Kanninen, Katja M; Malm, Tarja; Friedecký, David; Gynther, Mikko. 2022. Neuroscience. 496: 165-178 A1 Journal article (refereed), original research -
Microglial amyloid beta clearance is driven by PIEZO1 channels
Jäntti, Henna; Sitnikova, Valeriia; Ishchenko, Yevheniia; Shakirzyanova, Anastasia; Giudice, Luca; Ugidos, Irene F; Gómez-Budia, Mireia; Korvenlaita, Nea; Ohtonen, Sohvi; Belaya, Irina; Fazaludeen, Feroze; Mikhailov, Nikita; Gotkiewicz, Maria; Ketola, Kirsi; Lehtonen, Šárka; Koistinaho, Jari; Kanninen, Katja M; Hernández, Damian; Pébay, Alice; Giugno, Rosalba; Korhonen, Paula; Giniatullin, Rashid; Malm, Tarja. 2022. Journal of neuroinflammation. 19: . 147 A1 Journal article (refereed), original research -
Neuron-astrocyte transmitophagy is altered in Alzheimer's disease
Lampinen, Riikka; Belaya, Irina; Saveleva, Liudmila; Liddell, Jeffrey R; Rait, Dzhessi; Huuskonen, Mikko T; Giniatullina, Raisa; Sorvari, Annika; Soppela, Liisi; Mikhailov, Nikita; Boccuni, Isabella; Giniatullin, Rashid; Cruz-Haces, Marcela; Konovalova, Julia; Koskuvi, Marja; Domanskyi, Andrii; Hämäläinen, Riikka H; Goldsteins, Gundars; Koistinaho, Jari; Malm, Tarja; Chew, Sweelin; Rilla, Kirsi; White, Anthony R; Marsh-Armstrong, Nicholas; Kanninen, Katja M. 2022. Neurobiology of disease. 170: A1 Journal article (refereed), original research -
Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex
Choo, Xin Yi; McInnes, Lachlan E; Grubman, Alexandra; Wasielewska, Joanna M; Belaya, Irina; Burrows, Emma; Quek, Hazel; Martín, Jorge Cañas; Loppi, Sanna; Sorvari, Annika; Rait, Dzhessi; Powell, Andrew; Duncan, Clare; Liddell, Jeffrey R.; Tanila, Heikki; Polo, Jose M; Malm, Tarja; Kanninen, Katja M.; Donnelly, Paul S; White, Anthony R. 2022. International journal of molecular sciences. 23: A1 Journal article (refereed), original research -
Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer’s Disease
Puris, Elena; Saveleva, Liudmila; de Sousa Maciel, Izaque; Kanninen, Katja M.; Auriola, Seppo; Fricker, Gert. 2022. Molecular neurobiology. 2023; 60: 732-748 A1 Journal article (refereed), original research -
Single-Cell RNA-Seq Analysis of Olfactory Mucosal Cells of Alzheimer’s Disease Patients
Lampinen, Riikka; Fazaludeen, Mohammad Feroze; Avesani, Simone; Örd, Tiit; Penttilä, Elina; Lehtola, Juha-Matti; Saari, Toni; Hannonen, Sanna; Saveleva, Liudmila; Kaartinen, Emma; Fernández Acosta, Francisco; Cruz-Haces, Marcela; Löppönen, Heikki; Mackay-Sim, Alan; Kaikkonen, Minna U; Koivisto, Anne M; Malm, Tarja; White, Anthony R; Giugno, Rosalba; Chew, Sweelin; Kanninen, Katja M. 2022. Cells. 11: A1 Journal article (refereed), original research -
Subacute inhalation of ultrafine particulate matter triggers inflammation without altering amyloid beta load in 5xFAD mice
Saveleva, Liudmila; Vartiainen, Petra; Górová, Veronika; Chew, Sweelin; Belaya, Irina; Konttinen, Henna; Zucchelli, Martina; Korhonen, Paula; Kaartinen, Emma; Kortelainen, Miika; Lamberg, Heikki; Sippula, Olli; Malm, Tarja; Jalava, Pasi I; Kanninen, Katja M. 2022. Neurotoxicology. 89: 55-66 A1 Journal article (refereed), original research -
Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice
Puris, Elena; Jalkanen, Aaro; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. 2022. Brain disorders. 6: A1 Journal article (refereed), original research -
TUBE Project: Transport-Derived Ultrafines and the Brain Effects
Martikainen, Maria-Viola; Aakko-Saksa, Päivi; van den Broek, Lenie; Cassee, Flemming R; Carare, Roxana O; Chew, Sweelin; Dinnyes, Andras; Giugno, Rosalba; Kanninen, Katja M; Malm, Tarja; Muala, Ala; Nedergaard, Maiken; Oudin, Anna; Oyola, Pedro; Pfeiffer, Tobias V; Rönkkö, Topi; Saarikoski, Sanna; Sandström, Thomas; Schins, Roel PF; Topinka, Jan; Yang, Mo; Zeng, Xiaowen; Westerink, Remco HS; Jalava, Pasi I. 2022. International journal of environmental research and public health. 19: A1 Journal article (refereed), original research -
The Adverse Outcome Pathway Framework Applied to Neurological Symptoms of COVID-19
Hogberg, Helena T.; Lam, Ann; Ohayon, Elan; Shahbaz, Muhammad Ali; Clerbaux, Laure-Alix; Bal-Price, Anna; Coecke, Sandra; Concha, Rachel; De Bernardi, Francesca; Edrosa, Eizleayne; Hargreaves, Alan J.; Kanninen, Katja M.; Munoz, Amalia; Pistollato, Francesca; Saravanan, Surat; Garcia-Reyero, Natàlia; Wittwehr, Clemens; Sachana, Magdalini. 2022. Cells. 11: A2 Review article, Literature review, Systematic review -
An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo
Keuters, Meike Hedwig; Keksa-Goldsteine, Velta; Dhungana, Hiramani; Huuskonen, Mikko T; Pomeshchik, Yuriy; Savchenko, Ekaterina; Korhonen, Paula K; Singh, Yajuvinder; Wojciechowski, Sara; Lehtonen, ¦árka; Kanninen, Katja M; Malm, Tarja; Sirviö, Jouni; Muona, Anu; Koistinaho, Milla; Goldsteins, Gundars; Koistinaho, Jari. 2021. Scientific reports. 11: 3518 A1 Journal article (refereed), original research -
Increased iron content in the heart of the Fmr1 knockout mouse
Talvio, Karo; Kanninen, Katja M; White, Anthony R; Koistinaho, Jari; Castrén, Maija L. 2021. Biometals. 34: 947-954 A1 Journal article (refereed), original research -
Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice
Puris, Elena; Kouril, ¦tepán; Najdekr, Luká¨; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Friedecký, David; Gynther, Mikko. 2021. Scientific reports. 11: 13076 A1 Journal article (refereed), original research -
Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer's Disease
Belaya, Irina; Kucháriková, Nina; Górová, Veronika; Kysenius, Kai; Hare, Dominic J.; Crouch, Peter J.; Malm, Tarja; Atalay, Mustafa; White, Anthony R.; Liddell, Jeffrey R.; Kanninen, Katja M.. 2021. International journal of molecular sciences. 22: 8715 A1 Journal article (refereed), original research -
Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model
Puris, Elena; Auriola, Seppo; Korhonen, Paula; Loppi, Sanna; Kanninen, Katja M; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. 2021. Journal of pharmaceutical sciences. 110: 3953-3962 A1 Journal article (refereed), original research -
Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease
Belaya, Irina; Ivanova, Mariia; Sorvari, Annika; Ilicic, Marina; Loppi, Sanna; Koivisto, Hennariikka; Varricchio, Alessandra; Tikkanen, Heikki; Walker, Frederick R; Atalay, Mustafa; Malm, Tarja; Grubman, Alexandra; Tanila, Heikki; Kanninen, Katja M. 2020. Journal of neuroinflammation. 17: 271 A1 Journal article (refereed), original research -
Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy
Carare, RO; Aldea, R; Agarwal, N; Bacskai, BJ; Bechman, I; Boche, D; Bu, G; Bulters, D; Clemens, A; Counts, SE; de Leon, M; Eide, PK; Fossati, S; Greenberg, SM; Hamel, E; Hawkes, CA; Koronyo-Hamaoui, M; Hainsworth, AH; Holtzman, D; Ihara, M; et al [incl. Kanninen, K; Leinonen, V; Malm, T]. 2020. Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 21: e12053 A1 Journal article (refereed), original research -
Editorial: Air Pollution and Brain Health
White, Anthony; Kanninen, Katja; Malm, Tarja; Schins, Roel. 2020. Neurochemistry international. 141: 104900 B1 Non-refereed journal articles -
Glial smog: Interplay between air pollution and astrocyte-microglia interactions
Gómez-Budia, Mireia; Konttinen, Henna; Saveleva, Liudmila; Korhonen, Paula; Jalava, Pasi; Kanninen, Katja; Malm, Tarja. 2020. Neurochemistry international. 136: 104715 A2 Review article, Literature review, Systematic review -
Impairment of mitochondrial function by particulate matter: Implications for the brain
Chew, S; Kolosowska, N; Saveleva, L; Malm, T; Kanninen, KM. 2020. Neurochemistry international. 135: 104694 A2 Review article, Literature review, Systematic review -
Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation
Kolosowska, Natalia; Gotkiewicz, Maria; Dhungana, Hiramani; Giudice, Luca; Giugno, Rosalba; Box, Daphne; Huuskonen, Mikko T.; Korhonen, Paula; Scoyni, Flavia; Kanninen, Katja M.; Ylä-Herttuala, Seppo; Turunen, Tiia A.; Turunen, Mikko P.; Koistinaho, Jari; Malm, Tarja. 2020. Journal of neuroinflammation. 17: 194 A1 Journal article (refereed), original research -
Olfactory cell cultures to investigate health effects of air pollution exposure: implications for neurodegeneration
Kanninen, KM; Lampinen, R; Rantanen, LM; Odendaal, L; Jalava, P; Chew, S; White, AR. 2020. Neurochemistry international. 136: 104729 A2 Review article, Literature review, Systematic review -
Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals
Loppi, Sanna; Korhonen, Paula; Bouvy-Liivrand, Maria; Cagliola, Simone; Turunen, Tiia A; Turunen, Mikko P; Hernandez de Sande, Ana; Kolosowska, Natalia; Scoyni, Flavia; Rosell, Anna; García-Berrocoso, Teresa; Lemarchant, Sighild; Dhungana, Hiramani; Montaner, Joan; Koistinaho, Jari; Kanninen, Katja M; Kaikkonen, Minna U; Giugno, Rosalba; Heinäniemi, Merja; Malm, Tarja. 2020. Aging cell. 2021; 20: e13287 A1 Journal article (refereed), original research -
Proteomic and functional analyses in disease models reveal CLN5 protein involvement in mitochondrial dysfunction
Doccini, S; Morani, F; Nesti, C; Pezzini, F; Calza, G; Soliymani, R; Signore, G; Rocchiccioli, S; Kanninen, KM; Huuskonen, MT; Baumann, MH; Simonati, A; Lalowski, MM; Santorelli, FM. 2020. Cell death discovery. 6: 18 A1 Journal article (refereed), original research -
Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells
Chew, Sweelin; Lampinen, Riikka; Saveleva, Liudmila; Korhonen, Paula; Mikhailov, Nikita; Grubman, Alexandra; Polo, Jose M; Wilson, Trevor; Komppula, Mika; Rönkkö, Teemu; Gu, Cheng; Mackay-Sim, Alan; Malm, Tarja; White, Anthony R; Jalava, Pasi; Kanninen, Katja M. 2020. Particle and fibre toxicology. 17: 18 A1 Journal article (refereed), original research -
Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis
Korhonen, P; Pollari, E; Kanninen, KM; Savchenko, E; Lehtonen, ¦; Wojciechowski; S; Pomeshchik, Y; Van Den Bosch, L; Goldsteins, G; Koistinaho, J; Malm, T. 2019. IBRO reports. 6: 74-86 A1 Journal article (refereed), original research -
Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice
Singh, Y; Leinonen, H; Fazaludeen, F; Jaronen, M; Guest, D; Buckley, N; Byts, N; Oksa, P; Jalkanen, K; Iqbal, I; Huuskonen, M; Savchenko, E; Keksa-Goldsteine, V; Chew, S; Myllyharju, J; Tanila, H; Ooi, L; Koistinaho, J; Kanninen, KM; Malm, T. 2019. Human molecular genetics. 28: 3309-3322 A1 Journal article (refereed), original research -
NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes
Oksanen, M; Hyötyläinen, I; Trontti, K; Rolova, T; Wojciechowski, S; Koskuvi, M; Viitanen, M; Levonen, AL; Hovatta, I; Roybon, L; Lehtonen, ¦; Kanninen, KM; Hämäläinen, RH; Koistinaho, J. 2019. Glia. 2020; 68: 589-599 A1 Journal article (refereed), original research -
PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia
Konttinen, H; Cabral-da-Silva, MEC; Ohtonen, S; Wojciechowski, S; Shakirzyanova, A; Caligola, S; Giugno, R; Ishchenko, Y; Hernández, D; Fazaludeen, MF; Eamen, S; Budia, MG; Fagerlund, I; Scoyni, F; Korhonen, P; Huber, N; Haapasalo, A; Hewitt, AW; Vickers, J; Smith, GC; et al.. 2019. Stem cell reports. 13: 669-683 A1 Journal article (refereed), original research -
Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes
Gynther, Mikko; Puris, Elena; Peltokangas, Soile; Auriola, Seppo; Kanninen, Katja M; Koistinaho, Jari; Huttunen, Kristiina M; Ruponen, Marika; Vellonen, Kati-Sisko. 2018. Pharmaceutical research. 2019; 36: 17 A1 Journal article (refereed), original research -
CuII(atsm) Attenuates Neuroinflammation
Choo, Xin Yi; Liddell, Jeffrey R; Huuskonen, Mikko T; Grubman, Alexandra; Moujalled, Diane; Roberts, Jessica; Kysenius, Kai; Patten, Lauren; Quek, Hazel; Oikari, Lotta E; Duncan, Clare; James, Simon A; McInnes, Lachlan E; Hayne, David J; Donnelly, Paul S; Pollari, Eveliina; Vähätalo, Suvi; Lejavová, Katarína; Kettunen, Mikko I; Malm, Tarja; et al. [Incl Koistinaho, Jari; Kanninen, Katja]. 2018. Frontiers in neuroscience. 12: 668 A1 Journal article (refereed), original research -
HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage
Loppi, S; Kolosowska, N; Kärkkäinen, O; Korhonen, P; Huuskonen, M; Grubman, A; Dhungana, H; Wojciechowski, S; Pomeshchik, Y; Giordano, M; Kagechika, H; White, A; Auriola, S; Koistinaho, J; Landreth, G; Hanhineva, K; Kanninen, K; Malm, T. 2018. Brain behavior and immunity. 73: 670-681 A1 Journal article (refereed), original research -
Long-term exercise protects against cellular stresses in aged mice
Belaya, Irina; Suwa, Masataka; Chen, Tao; Giniatullin, Rashid; Kanninen, Katja; Atalay, Mustafa; Kumagai, Shuzo. 2018. Oxidative medicine and cellular longevity. 2018: 2894247 A1 Journal article (refereed), original research -
Mitochondrial Function in Alzheimer's Disease: Focus on Astrocytes
Lampinen, Riikka; Belaya, Irina; Boccuni, Isabella; Malm, Tarja; Kanninen, Katja M. Teoksessa: Gentile, Maria Teresa(toim.) , 2018. Astrocyte: Physiology and Pathology. s. 139-162. InTech Open A3 Book section, Chapters in research books -
PPARß/DELTA-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes
Konttinen, H; Gureviciene, I; Oksanen, M; Grubman, A; Loppi, S; Huuskonen, MT; Korhonen, P; Lampinen, R; Keuters, M; Belaya, I; Tanila, H; Kanninen, KM; Goldsteins, G; Landreth, G; Koistinaho, J; Malm, T. 2018. Glia. 2019; 67: 146-159 A1 Journal article (refereed), original research -
Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration
Abdalkader, Moataz; Lampinen, Riikka; Kanninen, Katja M; Malm, Tarja M; Liddell, Jeffrey R. 2018. Frontiers in neuroscience. 12: 466 A2 Review article, Literature review, Systematic review -
Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases
Kanninen Katja M, White Anthony R. Teoksessa: White Anthony R, Aschner Michael, Costa Lucio G, Bush Ashley I(toim.) , 2017. Biometals in neurodegenerative diseases : mechanisms and therapeutics. s. 415-438. Academic press A3 Book section, Chapters in research books -
Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease
Vellonen KS, Ihalainen J, Boucau M-C, Gosselet F, Picardat T, Gynther M, Kanninen KM, White AR, Malm T, Koistinaho J, Forsberg MM, Ruponen M. 2017. Pharmaceutical research. 34: 2652-2662 A1 Journal article (refereed), original research -
Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy
Nissinen J, Andrade P, Natunen T, Hiltunen M, Malm T, Kanninen K, Soares JI, Shatilloa O, Sallinen J, Ndode-Ekanea XE, Pitkänen A. 2017. Epilepsy research. 136: 18-34 A1 Journal article (refereed), original research -
Lack of collagen XV is protective after ischemic stroke in mice
Dhungana Hiramani, Huuskonen Mikko T, Pihlajaniemi Taina, Heljasvaara Ritva, Vivien Denis, Kanninen Katja M, Malm Tarja, Koistinaho Jari, Lemarchant Sighild. 2017. Cell death and disease. 8: 1-8 A1 Journal article (refereed), original research -
Loss of CLN5 causes altered neurogenesis in a childhood neurodegenerative disorder
Savchenko E, Singh Y, Konttinen H, Lejavova K, Mediavilla Santos L, Grubman A, Kärkkäinen V, Keksa-Goldsteine V, Naumenko N, Tavi P, White AR, Malm TM, Koistinaho J, Kanninen KM. 2017. Disease models and mechanisms. 10: 1089-1100 A1 Journal article (refereed), original research -
Metals and lysosomal storage disorders
Konttinen Henna, Lejavová Katarína, Malm Tarja, Kanninen Katja M. Teoksessa: White Anthony R, Aschner Michael, Costa Lucio G, Bush Ashley I(toim.) , 2017. Biometals in neurodegenerative diseases : mechanisms and therapeutics. s. 195-215. Academic press A3 Book section, Chapters in research books -
PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease
Oksanen M, Petersen AJ, Naumenko N, Puttonen K, Lehtonen ¦, Gubert Olivé M, Shakirzyanova A, Leskelä S, Sarajärvi T, Viitanen M, Rinne JO, Hiltunen M, Haapasalo A, Giniatullin R, Tavi P, Zhang SC, Kanninen KM, Hämäläinen RH, Koistinaho J. 2017. Stem cell reports. 9: 1885-1897 A1 Journal article (refereed), original research -
Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy
Leinonen Henri, Keksa-Goldsteine Velta, Ragauskas Symantas, Kohlmann Philip, Signh Yajuvinder, Savchencko Ekaterina, Puranen Jooseppi, Malm Tarja, Kalesnykas Giedrius, Koistinaho Jari, Tanila Heikki, Kanninen Katja M. 2017. Scientific reports. 7: 1597 A1 Journal article (refereed), original research -
Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation
Dhungana H, Huuskonen MT, Jaronen M, Lemarchant S, Ali H, Keksa-Goldsteine V, Goldsteins G, Kanninen KM, Koistinaho J, Malm T. 2017. Journal of neuroinflammation. 14: 237 A1 Journal article (refereed), original research -
The Copper bis(thiosemicarbazone) Complex Cu(II)(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu
Huuskonen, MT; Tuo, QZ; Loppi, S; Dhungana, H; Korhonen, P; McInnes, LE; Donnelly, PS; Grubman, A; Wojciechowski, S; Lejavova, K; Pomeshchik, Y; Periviita, L; Kosonen, L; Giordano, M; Walker, FR; Liu, R; Bush, AI; Koistinaho, J; Malm, T; White, AR; et al.. 2017. Neurotherapeutics. 14: 519-532 A1 Journal article (refereed), original research -
Type-I interferons in Parkinson's disease: innate inflammatory response drives fate of neurons in model of degenerative brain disorder: An editorial comment on 'Type-I interferons mediate the neuroinflammatory response and neurotoxicity induced by rotenone'
Kanninen KM, White AR. 2017. Journal of neurochemistry. 141: 9-11 A1 Journal article (refereed), original research -
ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. 2016. Molecular neurodegeneration. 11: 10 A1 Journal article (refereed), original research -
Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke
Lemarchant S, Dunghana H, Pomeshchik Y, Leinonen H, Kolosowska N, Korhonen P, Kanninen KM, García-Berrocoso T, Montaner J, Malm T, Koistinaho J. 2016. Glia. 64: 1492-507 A1 Journal article (refereed), original research -
Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy
Huuskonen MT, Loppi S, Dhungana H, Keksa-Goldsteine V, Lemarchant S, Korhonen P, Wojciechowski S, Pollari E, Valonen P, Koponen J, Takashima A, Landreth G, Goldsteins G, Malm T, Koistinaho J, Kanninen KM. 2016. Scientific reports. 6: 33176 A1 Journal article (refereed), original research -
Eksosomit aivosairauksissa - solujenvälisen kommunikoinnin uusi muoto
Kanninen K, Malm T. 2016. Duodecim. 132: 1957-63 A1 Journal article (refereed), original research -
Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. 2016. Molecular neurodegeneration. 11: 15 A1 Journal article (refereed), original research -
Exosomes in Alzheimer's disease
Malm Tarja, Loppi Sanna, Kanninen Katja M. 2016. Neurochemistry international. 97: 193-199 A1 Journal article (refereed), original research -
Multitasking Microglia and Alzheimer's Disease: Diversity, Tools and Therapeutic Targets
Grubman Alexandra, Kanninen Katja M, Malm Tarja. 2016. Journal of molecular neuroscience. 60: 390-404 A1 Journal article (refereed), original research -
Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes
Liddell Jeffrey R, Lehtonen Sarka, Duncan Clare, Keksa-Goldsteine Velta, Levonen Anna-Liisa, Goldsteins Gundars, Malm Tarja, White Anthony R, Koistinaho Jari, Kanninen Katja M. 2016. Journal of neuroinflammation. 13: 1-14 A1 Journal article (refereed), original research -
Applications of the Keap1-Nrf2 system for gene and cell therapy
Kanninen Katja M, Pomeshchik Yuriy, Leinonen Hanna, Malm Tarja, Koistinaho Jari, Levonen Anna-Liisa. 2015. Free radical biology and medicine. 88: 350-361 A2 Review article, Literature review, Systematic review -
Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage
Rolova Taisia, Dhungana Hiramani, Korhonen Paula, Valonen Piia, Kolosowska Natalia, Konttinen Henna, Kanninen Katja, Tanila Heikki, Malm Tarja, Koistinaho Jari. 2015. Aging and disease. [epub ahead of print 3 Dec 2015]: - A1 Journal article (refereed), original research -
Editorial: Metals and neurodegeneration: restoring the balance
White Anthony R, Kanninen Katja M, Crouch Peter J. 2015. Frontiers in aging neuroscience. 7: 127 A1 Journal article (refereed), original research -
Exosomes as new diagnostic tools in CNS diseases
Kanninen Katja M, Bister Nea, Koistinaho Jari, Malm Tarja. 2015. Biochimica et biophysica acta: molecular basis of disease. 2016; 1862: 403-410 A2 Review article, Literature review, Systematic review -
Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation
Korhonen Paula, Kanninen Katja M, Lehtonen Sarka, Lemarchant Sighild, Puttonen Katja A, Oksanen Minna, Dhungana Hiramani, Loppi Sanna, Pollari Eveliina, Wojciechowski Sara, Kidin Iurii, Garcia-Berrocoso Teresa, Giralt Dolors, Montaner Joan, Koistinaho Jan I, Malm Tarja. 2015. Brain behavior and immunity. 49: 322-336 A1 Journal article (refereed), original research -
Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?
Grubman Alexandra, Pollari Eveliina, Duncan Clare, Caragounis Aphrodite, Blom Tea, Volitakis Irene, Wong Andrew, Cooper Jonathan, Crouch Peter J, Koistinaho Jari, Jalanko Anu, White Anthony R, Kanninen Katja M. 2014. Metallomics. 2014 Apr;6(4): 932-943 A1 Journal article (refereed), original research -
Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder
Grubman Alexandra, Lidgerwood Grace E, Duncan Clare, Bica Laura, Tan Jiang-Li, Parker Sarah J, Caragounis Aphrodite, Meyerowitz Jodi, Volitakis Irene, Moujalled Diane, Liddell Jeffrey R, Hickey James L, Horne Malcolm, Longmuir Shoshanah, Koistinaho Jari, Donnelly Paul S, Crouch Peter J, Tammen Imke, White Anthony R, Kanninen Katja M. 2014. Acta neuropathologica communications. : -- A1 Journal article (refereed), original research -
Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury
Pomeshchik Y, Kidin I, Korhonen P, Savchenko E, Jaronen M, Lehtonen S, Wojciechowski S, Kanninen K, Koistinaho J, Malm T. 2014. Brain behavior and immunity. 2014 Aug 18 ePub ahead of print: -- A1 Journal article (refereed), original research -
Nrf2 regulates neurogenesis and protects neural progenitor cells against aß toxicity
Kärkkäinen Virve, Pomeshchik Yuriy, Savchenko Ekaterina, Dhungana Hiramani, Kurronen Antti, Lehtonen Sarka, Naumenko Nikolay, Tavi Pasi, Levonen Anna-Liisa, Yamamoto Masayaki, Malm Tarja, Magga Johanna, Kanninen Katja M, Koistinaho Jari. 2014. Stem cells. 32: 1904-1916 A1 Journal article (refereed), original research -
Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis
Roberts Blaine R, Lim Nastasia KH, McAllum Erin J, Donnelly Paul S, Hare Dominic J, Doble Philip A, Turner Bradley J, Price Katherine A, Lim Sin Chun, Paterson Brett M, Hickey James L, Rhoads Timothy W, Williams Jared R, Kanninen Katja M, Hung Lin W, Liddell Jeffrey R, Grubman Alexandra, Monty Jean-Francois, Llanos Roxana M, Kramer David R, Mercer Julian FB, Bush Ashley I, Masters Colin L, Duce James A, Li Qiao-Xin, Beckman Joseph S, Barnham Kevin J, White Anthony R, Crouch Peter J. 2014. Journal of neuroscience. 2014 Jun 4;34(23): 8021-8031 A1 Journal article (refereed), original research -
Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43
Moujalled Diane, James Janine L, Yang Shu, Zhang Katharine, Duncan Clare, Moujalled Donia M, Parker Sarah J, Caragounis Aphrodite, Lidgerwood Grace, Turner Bradley J, Atkin Julie D, Grubman Alexandra, Liddell Jeffrey R, Proepper Christian, Boeckers Tobias M, Kanninen Katja M, Blair Ian, Crouch Peter J, White Anthony R. 2014. Human molecular genetics. 2015; 24: 1655-1669 A1 Journal article (refereed), original research -
X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder
Grubman A, James SA, James J, Duncan C, Volitakis I, Hickey JL, Crouch PJ, Donnelly PS, Kanninen KM, Liddell JR, Cotman SL, de Jonge MD, White AR. 2014. Chemical science. 2014 Jun;5(6): 2503-2516 A1 Journal article (refereed), original research -
ADAMTS proteoglycanases in the physiological and pathological central nervous system
Lemarchant S, Pruvost M, Montaner J, Emery E, Vivien D, Kanninen K, Koistinaho J. 2013. Journal of neuroinflammation. 2013 Oct 31;10(1): 133 A2 Review article, Literature review, Systematic review -
Biometals in rare neurodegenerative disorders of childhood
Parker SJ, Koistinaho J, White AR, Kanninen KM. 2013. Frontiers in aging neuroscience. 5: x-x A2 Review article, Literature review, Systematic review -
Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit
Rolova T, Puli L, Magga J, Dhungana H, Kanninen K, Wojciehowski S, Salminen A, Tanila H, Koistinaho J, Malm T. 2013. Neurobiology of disease. [Epub ahead of print]: 16-29 A1 Journal article (refereed), original research -
Does Nrf2 Gene Transfer Facilitate Recovery After Contusion Spinal Cord Injury?
Pomeshchik Y, Kidin I, Savchenko E, Rolova T, Yamamoto M, Levonen AL, Ylä-Herttuala S, Malm T, Kanninen K, Koistinaho J. 2013. Antioxidants and redox signaling. 2013 Aug 20. [Epub ahead of print]: x-x A1 Journal article (refereed), original research -
Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis
Kanninen KM, Grubman A, Meyerowitz J, Duncan C, Tan JL, Parker SJ, Crouch PJ, Paterson BM, Hickey JL, Donnelly PS, Volitakis I, Tammen I, Palmer DN, White AR. 2013. PLoS ONE. 8: e58644 A1 Journal article (refereed), original research -
Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress
Moujalled D, James JL, Parker SJ, Lidgerwood GE, Duncan C, Meyerowitz J, Nonaka T, Hasegawa M, Kanninen KM, Grubman A, Liddell JR, Crouch PJ, White AR. 2013. PLoS ONE. 8(6): e67433.: e67433 A1 Journal article (refereed), original research -
Adult and neonatal astrocytes exhibit diverse gene expression profiles in response to beta amyloid ex vivo
Kurronen A, Pihlaja R, Pollari E, Kanninen K, Storvik M, Wong G, Koistinaho M, Koistinaho J. 2012. World journal of neuroscience. 2/2012: 57-67 A1 Journal article (refereed), original research -
Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis
Pollari Eveliina, Savchenko Ekaterina, Jaronen Merja, Kanninen Katja, Malm Tarja, Wojciechowski Sara, Ahtoniemi Toni, Goldsteins Gundars, Giniatullina Raisa, Giniatullin Rashid, Koistinaho Jari, Magga Johanna. 2011. Journal of neuroinflammation. 84: 1-14 A1 Journal article (refereed), original research -
Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway
Kanninen K, White AR, Koistinaho J, Malm T. 2011. International journal of alzheimers disease. : -- A2 Review article, Literature review, Systematic review -
Utilization of APPswe/PS1dE9 Transgenic Mice in Research of Alzheimer's Disease: Focus on Gene Therapy and Cell-Based Therapy Applications
Malm T, Koistinaho J, Kanninen K. 2011. International journal of alzheimers disease. : -- A2 Review article, Literature review, Systematic review -
Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease
Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J. 2009. Proceedings of the National Academy of Sciences of the United States of America. 106: 16505-16510 A1 Journal article (refereed), original research -
Nrf2 in Alzheimer's Disease
Kanninen K. 2009. Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti G5 Doctoral dissertation (article) -
Nuclear factor erythroid 2-related factor 2 protects against beta amyloid
Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL, Koistinaho J. 2008. Molecular and cellular neuroscience. 39: 302-313 A1 Journal article (refereed), original research -
Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden
Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, van Groen T, Tanila H, Koistinaho J. 2007. Journal of neuroscience. 27: 3712-3721 A1 Journal article (refereed), original research -
Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis
Ahtoniemi T, Goldsteins G, Keksa-Goldsteine V, Malm T, Kanninen K, Salminen A, Koistinaho J. 2007. Molecular pharmacology. 71: 30-37 A1 Journal article (refereed), original research -
Beta-amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits
Malm T, Ort M, Tähtivaara L, Jukarainen N, Goldsteins G, Puoliväli J, Nurmi A, Pussinen R, Ahtoniemi T, Miettinen T-K, Kanninen K, Leskinen S, Vartiainen N, Yrjänheikki J, Laatikainen R, Harris-White ME, Koistinaho M, Frautschy SA, Bures J. 2006. Proceedings of the National Academy of Sciences of the United States of America. 103: 8852-8857 A1 Journal article (refereed), original research -
The Eleventh Annual Post-Graduate Symposium of the A.I. Virtanen Institute Graduate School. AIVI Winter School 2006. Abstracts
Keinänen R, Huttunen J, Häkkinen S-K, Kanninen K, Lipponen A, Louhivuori L, Mäkelä K, Mäntylä T, Tusa M. 2006. Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti. . - C2 Edited book, conference proceedings or special issue of a journal -
Glycosylation changes in Alzheimer's disease as revealed by a proteomic approach
Kanninen K, Goldsteins G, Auriola S, Alafuzoff I, Koistinaho J. 2004. Neuroscience letters. 367: 235-240 A1 Journal article (refereed), original research