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Kirsi Rilla

Kirsi Rilla

Senior Researcher

Cell biologist and leader of a research group focused on the biology of extracellular vesicles (E...

Institute of Biomedicine, School of Medicine, Faculty of Health Sciences

kirsi.rilla@uef.fi | +358 40 355 3218

Information Publications

Research groups

Rilla Lab 01.09.2013 -

Projects

GeneCellNano Flagship 01.07.2020 - 30.06.2028

Publications

104/104 items

DPYSL5 is highly expressed in treatment-induced neuroendocrine prostate cancer and promotes lineage plasticity via EZH2/PRC2
Kaarijärvi, Roosa; Kaljunen, Heidi; Nappi, Lucia; Fazli, Ladan; Kung, Sonia H. Y.; Hartikainen, Jaana M.; Paakinaho, Ville; Capra, Janne; Rilla, Kirsi; Malinen, Marjo; Mäkinen, Petri I.; Ylä-Herttuala, Seppo; Zoubeidi, Amina; Wang, Yuzhuo; Gleave, Martin E.; Hiltunen, Mikko; Ketola, Kirsi. 2024. Communications biology. 7: . 108 A1 Journal article (refereed), original research
Development of Focused Ultrasound-Assisted Nanoplexes for RNA Delivery
Ranjan, Sanjeev; Bosch, Stef; Lukkari, Hannamari; Schirmer, Johanna; Aaltonen, Niina; Nieminen, Heikki J; Lehto, Vesa-Pekka; Urtti, Arto; Lajunen, Tatu; Rilla, Kirsi. 2024. Nanomaterials. 14: A1 Journal article (refereed), original research
EP300/CREBBP acetyltransferase inhibition limits steroid receptor and FOXA1 signaling in prostate cancer cells
Huttunen, Jasmin; Aaltonen, Niina; Helminen, Laura; Rilla, Kirsi; Paakinaho, Ville. 2024. Cellular and molecular life sciences. 81: . 160 A1 Journal article (refereed), original research
Increased secretion of adipocyte-derived extracellular vesicles is associated with adipose tissue inflammation and the mobilization of excess lipid in human obesity
Matilainen, Johanna; Berg, Viivi; Vaittinen, Maija; Impola, Ulla; Mustonen, Anne-Mari; Männistö, Ville; Malinen, Marjo; Luukkonen, Veera; Rosso, Natalia; Turunen, Tanja; Käkelä, Pirjo; Palmisano, Silvia; Arasu, Uma Thanigai; Sihvo, Sanna P.; Aaltonen, Niina; Härkönen, Kai; Caddeo, Andrea; Kaminska, Dorota; Pajukanta, Päivi; Kaikkonen, Minna U.; Tiribelli, Claudio; Käkelä, Reijo; Laitinen, Saara; Pihlajamäki, Jussi; Nieminen, Petteri; Rilla, Kirsi. 2024. Journal of translational medicine. 22: . 623 A1 Journal article (refereed), original research
PL3 CendR peptide shows specific uptake in cultured Y79 retinoblastoma cells with nucleolar accumulation
Korhonen, Sonja; Bosch, Stef; Erkinheimo, Antero; Lajunen, Tatu; Rilla, Kirsi; Teesalu, Tambet; Subrizi, Astrid; Ruponen, Marika; Urtti, Arto; Reinisalo, Mika. 2024. European journal of pharmaceutical sciences. 201: A1 Journal article (refereed), original research
Selective drug delivery to the retinal cells: Biological barriers and avenues
Ramsay, Eva; Lajunen, Tatu; Bhattacharya, Madhushree; Reinisalo, Mika; Rilla, Kirsi; Kidron, Heidi; Terasaki, Tetsuya; Urtti, Arto. 2023. Journal of controlled release. 361: 1-19 A1 Journal article (refereed), original research
The Hyaluronan-Rich Zones of Plasma Membrane Protrusions and Extracellular Vesicles
Rilla, Kirsi. Teoksessa: Passi, Alberto(toim.) , 2023. Hyaluronan: Structure, Biology and Biotechnology. s. 55-75. Springer B2 Book section
The prognostic and predictive role of tumor-infiltrating lymphocytes (FoxP3 + and CD8 +) and tumor-associated macrophages in early HER2 + breast cancer
Jääskeläinen, Minna M; Tiainen, Satu; Siiskonen, Hanna; Ahtiainen, Maarit; Kuopio, Teijo; Rönkä, Aino; Kettunen, Tiia; Hämäläinen, Kirsi; Rilla, Kirsi; Harvima, Ilkka; Mannermaa, Arto; Auvinen, Päivi. 2023. Breast cancer research and treatment. 201: 183-192 A1 Journal article (refereed), original research
A quick pipeline for the isolation of 3D cell culture‐derived extracellular vesicles
Kyykallio, Heikki; Faria, Alessandra V. S.; Hartmann, Rosabella; Capra, Janne; Rilla, Kirsi; Siljander, Pia R‐M. 2022. Journal of extracellular vesicles. 11: A1 Journal article (refereed), original research
Counts of hyaluronic acid-containing extracellular vesicles decrease in naturally occurring equine osteoarthritis
Mustonen, Anne-Mari; Lehmonen, Nina; Oikari, Sanna; Capra, Janne; Raekallio, Marja; Mykkänen, Anna; Paakkonen, Tommi; Rilla, Kirsi; Niemelä, Tytti; Nieminen, Petteri. 2022. Scientific reports. 12: . 17550 A1 Journal article (refereed), original research
Fatty Acid Fingerprints and Hyaluronic Acid in Extracellular Vesicles from Proliferating Human Fibroblast-like Synoviocytes
Mustonen, Anne-Mari; Paakkonen, Tommi; Matilainen, Johanna; Rilla, Kirsi; Käkelä, Reijo; Malinen, Marjo; Takabe, Piia; Oikari, Sanna; Capra, Janne; Sihvo, Sanna P; Ryökäs, Pauliina; Nieminen, Petteri. 2022. International journal of molecular sciences. 23: A1 Journal article (refereed), original research
Isolation of Extracellular Vesicles From the Bronchoalveolar Lavage Fluid of Healthy and Asthmatic Horses
Höglund, Nina; Koho, Ninna; Rossi, Heini; Karttunen, Jenni; Mustonen, Anne-Mari; Nieminen, Petteri; Rilla, Kirsi; Oikari, Sanna; Mykkänen, Anna. 2022. Frontiers in veterinary science. 9: . 894189 A1 Journal article (refereed), original research
MCF10CA Breast Cancer Cells Utilize Hyaluronan-Coated EV-Rich Trails for Coordinated Migration
Aaltonen, Niina; Kyykallio, Heikki; Tollis, Sylvain; Capra, Janne; Hartikainen, Jaana M.; Matilainen, Johanna; Oikari, Sanna; Rilla, Kirsi. 2022. Frontiers in oncology. 12: . 869417 A1 Journal article (refereed), original research
Microscopic characterization reveals the diversity of EVs secreted by GFP-HAS3 expressing MCF7 cells
Capra, Janne; Härkönen, Kai; Kyykallio, Heikki; Vihinen, Helena; Jokitalo, Eija; Rilla, Kirsi. 2022. European journal of cell biology. 101: A1 Journal article (refereed), original research
Neuron-astrocyte transmitophagy is altered in Alzheimer's disease
Lampinen, Riikka; Belaya, Irina; Saveleva, Liudmila; Liddell, Jeffrey R; Rait, Dzhessi; Huuskonen, Mikko T; Giniatullina, Raisa; Sorvari, Annika; Soppela, Liisi; Mikhailov, Nikita; Boccuni, Isabella; Giniatullin, Rashid; Cruz-Haces, Marcela; Konovalova, Julia; Koskuvi, Marja; Domanskyi, Andrii; Hämäläinen, Riikka H; Goldsteins, Gundars; Koistinaho, Jari; Malm, Tarja; Chew, Sweelin; Rilla, Kirsi; White, Anthony R; Marsh-Armstrong, Nicholas; Kanninen, Katja M. 2022. Neurobiology of disease. 170: A1 Journal article (refereed), original research
Advanced nanoengineered - customized point-of-care tools for prostate-specific antigen
Numan, Arshid; Singh, Sima; Zhan, Yiqiang; Li, Lijie; Khalid, Mohammad; Rilla, Kirsi; Ranjan, Sanjeev; Cinti, Stefano. 2021. Microchimica acta. 189: 27 A2 Review article, Literature review, Systematic review
Characterization of hyaluronan-coated extracellular vesicles in synovial fluid of patients with osteoarthritis and rheumatoid
Mustonen, Anne-Mari; Capra, Janne; Rilla, Kirsi; Lehenkari, Petri; Oikari, Sanna; Kääriäinen, Tommi; Joukainen, Antti; Kröger, Heikki; Paakkonen, Tommi; Matilainen, Johanna; Nieminen, Petteri. 2021. Bmc musculoskeletal disorders. 22: 247 A1 Journal article (refereed), original research
Diverse plasma membrane protrusions act as platforms for extracellular vesicle shedding
Rilla, Kirsi. 2021. Journal of extracellular vesicles. 10: e12148 A2 Review article, Literature review, Systematic review
Enhanced gene expression by a novel designed leucine zipper endosomolytic peptide
Ahmad, Aqeel; Rilla, Kirsi; Zou, Jing; Zhang, Weikai; Pyykkö, Ilmari; Kinnunen, Paavo; Ranjan, Sanjeev. 2021. International journal of pharmaceutics. 601: 120556 A1 Journal article (refereed), original research
Nano-enabled strategies to combat methicillin-resistant Staphylococcus aureus
Singh, Sima; Numan, Arshid; Somaily, Hamoud H.; Gorain, Bapi; Ranjan, Sanjeev; Rilla, Kirsi; Siddique, Hifzur R.; Kesharwani, Prashant. 2021. Materials science and engineering c: materials for biological applications. 129: 112384 A2 Review article, Literature review, Systematic review
The power of imaging to understand extracellular vesicle biology in vivo
Verweij, FJ; Balaj, L; Boulanger, CM; Carter, DR; Compeer, EB; D'Angelo, G; El Andaloussi, S; Goetz, JG; Gross, JC; Hyenne, V; Krämer-Albers, EM; Lai, CP; Loyer, X; Marki, A; Momma, S; Nolte-'t Hoen, ENM; Pegtel, DM; Peinado, H; Raposo, G; Rilla, K; Tahara, H; Théry, C; van Royen, ME; Vandenbroucke, RE; Wehman, AM; Witwer, K; Wu, Z; Wubbolts, R; van Niel, G. 2021. Nature methods. 18: 1013-1026 A2 Review article, Literature review, Systematic review
High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils
Aaltonen, Niina; Singha, Prosanta; Jakupovic, Hermina; Wirth, Thomas; Samaranayake, Haritha; Pasonen-Seppänen, Sanna; Rilla, Kirsi; Varjosalo, Markku; Edgington-Mitchell, Laura; Kasperkiewicz, Paulina; Drag, Marcin; Kälvälä, Sara; Moisio, Eemeli; Savinainen, Juha; Laitinen, Jarmo. 2020. Biological procedures online. 22: 6 A1 Journal article (refereed), original research
Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism
Matilainen, Johanna; Mustonen, Anne-Mari; Rilla, Kirsi; Käkelä, Reijo; Sihvo, Sanna; Nieminen, Petteri. 2020. Lipids in health and disease. 19: 70 A1 Journal article (refereed), original research
Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aß
Marttinen, Mikael; Ferreira, Catarina B; Paldanius, Kaisa M A; Takalo, Mari; Natunen, Teemu; Mäkinen, Petra; Leppänen, Luukas; Leinonen, Ville; Tanigaki, Kenji; Kang, Gina; Hiroi, Noboru; Soininen, Hilkka; Rilla, Kirsi; Haapasalo, Annakaisa; Hiltunen, Mikko. 2020. Cells. 9: 2482 A1 Journal article (refereed), original research
The density and length of filopodia associate with the activity of hyaluronan synthesis in tumor cells
Kyykallio, Heikki; Oikari, Sanna; Álvez, María Bueno; Dodd, Carlos José Gallardo; Capra, Janne; Rilla, Kirsi. 2020. Cancers. 12: 1908 A1 Journal article (refereed), original research
The prognostic and predictive role of the neutrophil-to-lymphocyte ratio and the monocyte-to-lymphocyte ratio in early breast cancer, especially in the HER2+ subtype
Tiainen, Satu; Rilla, Kirsi; Hämäläinen, Kirsi; Oikari, Sanna; Auvinen, Päivi. 2020. Breast cancer research and treatment. 2021; 185: 63-72 A1 Journal article (refereed), original research
Activated hyaluronan metabolism in the tumor matrix - Causes and consequences
Tammi, Markku I; Oikari, Sanna; Pasonen-Seppänen, Sanna; Rilla, Kirsi; Auvinen, Päivi; Tammi, Raija H. 2019. Matrix biology. 78-79: 147-164 A2 Review article, Literature review, Systematic review
CD44s Assembles Hyaluronan Coat on Filopodia and Extracellular Vesicles and Induces Tumorigenicity of MKN74 Gastric Carcinoma Cells
Härkönen, K; Oikari, S; Kyykallio, H; Capra, J; Hakkola, S; Ketola, K; Thanigai Arasu, U; Daaboul, G; Malloy, A; Oliveira, C; Jokelainen, O; Sironen, R; Hartikainen, JM; Rilla, K. 2019. Cells. 8: 276 A1 Journal article (refereed), original research
Correlative light and electron microscopy is a powerful tool to study interactions of extracellular vesicles with recipient cells
Arasu, Uma Thanigai; Härkönen, Kai; Koistinen, Arto; Rilla, Kirsi. 2019. Experimental cell research. 376: 149-158 A1 Journal article (refereed), original research
Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2)
Melero-Fernandez de Mera, RM; Arasu, UT; Kärnä, R; Oikari, S; Rilla, K; Vigetti, D; Passi, A; Heldin, P; Tammi, MI; Deen, AJ. 2019. Matrix biology. 80: 85-103 A1 Journal article (refereed), original research
Extracellular vesicles are integral and functional components of the extracellular matrix
Rilla, Kirsi; Mustonen, Anne-Mari; Thanigai, Arasu Uma; Härkönen, Kai; Matilainen, Johanna; Nieminen, Petteri. 2019. Matrix biology. 75-76: 201-219 A2 Review article, Literature review, Systematic review
HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells
Arasu, UT; Deen, AJ; Pasonen-Seppänen, S; Heikkinen, S; Lalowski, M; Kärnä, R; Härkönen, K; Mäkinen, P; Lázaro-Ibáñez, E; Siljander, PR; Oikari, S; Levonen, AL; Rilla, K. 2019. Cellular and molecular life sciences. [Published: 09 December 2019]: 1-23 A1 Journal article (refereed), original research
Hyaluronan histochemistry - A potential new tool to assess the progress of liver disease from simple steatosis to hepatocellular carcinoma
Mustonen, Anne-Mari; Salvén, Anu; Kärjä, Vesa; Rilla, Kirsi; Matilainen, Johanna; Nieminen, Petteri. 2019. Glycobiology. 29: 298-306 A1 Journal article (refereed), original research
Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters
Hellinen, Laura; Sato, Kazuki; Reinisalo, Mika; Kidron, Heidi; Rilla, Kirsi; Tachikawa, Masanori; Uchida, Yasuo; Terasaki, Tetsuya; Urtti, Arto. 2019. Investigative ophthalmology and visual science. 60: 5022-5034 A1 Journal article (refereed), original research
Tumor microenvironment and breast cancer survival: combined effects of breast fat, M2 macrophages and hyaluronan create a dismal prognosis
Tiainen, S; Masarwah, A; Oikari, S; Rilla, K; Hämäläinen, K; Sudah, M; Sutela, A; Vanninen, R; Ikonen, J; Tammi, R; Tammi, M; Auvinen, P. 2019. Breast cancer research and treatment. 2020; 179: 565-575 A1 Journal article (refereed), original research
Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas
Valkonen, Mari; Haapasalo, Hannu; Rilla, Kirsi; Tyynelä-Korhonen, Kristiina; Soini, Ylermi; Pasonen-Seppänen, Sanna. 2018. Bmc cancer. 18: 664 A1 Journal article (refereed), original research
Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs
Karttunen, Jenni; Heiskanen, Mette; Navarro-Ferrandis, Vicente; Das Gupta, Shalini; Lipponen, Anssi; Puhakka, Noora; Rilla, Kirsi; Koistinen, Arto; Pitkänen, Asla. 2018. Journal of extracellular vesicles. 2019; 8: 1555410 A1 Journal article (refereed), original research
DHCR24 exerts neuroprotection upon inflammation-induced neuronal death
Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M. 2017. Journal of neuroinflammation. : 215 A1 Journal article (refereed), original research
EMT induced by EGF and wounding activates hyaluronan synthesis machinery and EV shedding in rat primary mesothelial cells
Koistinen Ville, Härkönen Kai, Kärnä Riikka, Arasu Uma Thanigi, OIkari Sanna, Rilla Kirsi. 2017. Matrix biology. 63: 38-54 A1 Journal article (refereed), original research
Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles
Arasu UT, Kärnä R, Härkönen K, Oikari S, Koistinen A, Kröger H, Qu C, Lammi MJ, Rilla K. 2017. Matrix biology. 64: 54-68 A1 Journal article (refereed), original research
Metastatic state of parent cells influences the uptake and functionality of prostate cancer cell-derived extracellular vesicles
Lazaro-Ibanez Elisa, Neuvonen Maarit, Takatalo Maarit, Arasu Uma Thanigai, Capasso Cristian, Cerullo Vincenzo, Rhim Johng S, Rilla Kirsi, Yliperttula Marjo, Siljander Pia R -M. 2017. Journal of extracellular vesicles. 6: 1354645 A1 Journal article (refereed), original research
Molecular targets of chloropicrin in human airway epithelial cells
Pesonen M, Rysä J, Storvik M, Rilla K, Pasanen M, Vähäkangas K. 2017. Toxicology in vitro. 42: 247-254 A1 Journal article (refereed), original research
Ekstrasellulaarivesikkelit tulevaisuuden biomarkkereina
Rilla Kirsi, Hiltunen Mikko. 2016. BestPractice Psykiatria/neurologia: lääketieteen asiantuntijoiden ammattilehti. 4: 11-13 D1 Article in a trade journal
First in vivo detection and characterization of hyaluronan-coated extracellular vesicles in human synovial fluid
Mustonen A-M, Nieminen P, Joukainen A, Jaroma A, Kääriäinen T, Kröger H, Lázaro-Ibáñez E, Siljander PR-M, Kärjä V, Härkönen K, Koistinen A, Rilla K. 2016. Journal of orthopaedic research. 34: 1960-1968 A1 Journal article (refereed), original research
High extent of O-GlcNAcylation in breast cancer cells correlates with the levels of HAS enzymes, accumulation of hyaluronan, and poor outcome
Tiainen Satu, Oikari Sanna, Tammi Markku, Rilla Kirsi, Hämäläinen Kirsi, Tammi Raija, Kosma Veli-Matti, Auvinen Päivi. 2016. Breast cancer research and treatment. 160: 237-247 A1 Journal article (refereed), original research
Hyaluronan-positive plasma membrane protrusions exist on mesothelial cells in vivo
Koistinen Ville, Jokela Tiina, Oikari Sanna, Kärnä Riikka, Tammi Markku, Rilla Kirsi. 2016. Histochemistry and cell biology. 145: 531-544 A1 Journal article (refereed), original research
Mesotheliomas show higher hyaluronan positivity around tumor cells than metastatic pulmonary adenocarcinomas
Törrönen Kari, Soini Ylermi, Pääkkö Paavo, Parkkinen Jyrki, Sironen Reijo, Rilla Kirsi. 2016. Histology and histopathology. 31: 1113-1122 A1 Journal article (refereed), original research
UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression
Deen AJ, Arasu UT, Pasonen-Seppänen S, Hassinen A, Takabe P, Wojciechowski S, Kärnä R, Rilla K, Kellokumpu S, Tammi R, Tammi M, Oikari S. 2016. Cellular and molecular life sciences. 73: 3183-3204 A1 Journal article (refereed), original research
Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia
Koistinen Ville, Kärnä Riikka, Koistinen Arto, Arjonen Antti, Tammi Markku, Rilla Kirsi. 2015. Experimental cell research. 337: 179-191 A1 Journal article (refereed), original research
Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles
Rilla Kirsi, Koistinen Arto. 2015. International journal of cell biology. 2015: 8 pages A1 Journal article (refereed), original research
High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation
Sokka Miiko, Rilla Kirsi, Miinalainen Ilkka, Pospiech Helmut, Syväoja Juhani E.. 2015. Nucleic acids research. 43: 4975-4989 A1 Journal article (refereed), original research
Hyaluronan synthase 1: a mysterious enzyme with unexpected functions
Siiskonen Hanna, Oikari Sanna, Pasonen-Seppänen Sanna, Rilla Kirsi. 2015. Frontiers in immunology. epub: A2 Review article, Literature review, Systematic review
Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion
Takabe Piia, Bart Genevieve, Ropponen Antti, Rilla Kirsi, Tammi Markku, Tammi Raija, Pasonen-Seppanen Sanna. 2015. Experimental cell research. 337: 1-15 A1 Journal article (refereed), original research
Interleukin-1ß-induced Reduction of CD44 Ser-325 Phosphorylation in Human Epidermal Keratinocytes Promotes CD44 Homomeric Complexes, Binding to Ezrin, and Extended, Monocyte-adhesive Hyaluronan Coats
Jokela Tiina, Oikari Sanna, Takabe Piia, Rilla Kirsi, Kärnä Riikka, Tammi Markku, Tammi Raija. 2015. Journal of biological chemistry. 290: 12379-12393 A1 Journal article (refereed), original research
Chloropicrin-induced toxic responses in human lung epithelial cells
Pesonen Maija, Häkkinen Merja, Rilla Kirsi, Juvonen Risto, Kuitunen Tapio, Pasanen Markku, Vähäkangas Kirsi. 2014. Toxicology letters. 226: 236-244 A1 Journal article (refereed), original research
Chondrocytic cells express the taurine transporter on their plasma membrane and regulate its expression under anisotonic conditions
Karjalainen Hannu M, Qu Chengjuan, Leskelä Stina S, Rilla Kirsi, Lammi Mikko J. 2014. Amino acids. 47: 561-570 A1 Journal article (refereed), original research
Correlative light and electron microscopy reveals the morphological changes of HAS3 overexpressing breast cancer cells and their hyaluronan-dependent plasma membrane protrusions
Rilla K, Koistinen AP. 2014.
Extensive CD44-dependent hyaluronan coats on human bone marrow-derived mesenchymal stem cells produced by hyaluronan synthases HAS1, HAS2 and HAS3
Qu C, Rilla K, Tammi R, Tammi M, Kröger H, Lammi MJ. 2014. International journal of biochemistry and cell biology. 48: 45-54 A1 Journal article (refereed), original research
High numbers of macrophages, especially M2-like (CD163-positive), correlate with hyaluronan accumulation and poor outcome in breast cancer
Tiainen Satu, Tumelius Ritva, Rilla Kirsi, Hämäläinen Kirsi, Tammi Markku, Tammi Raija, Kosma Veli-Matti, Oikari Sanna, Auvinen Päivi. 2014. Histopathology. 2014; 66: 873-883 A1 Journal article (refereed), original research
Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival
Auvinen Päivi, Rilla Kirsi, Tumelius Ritva, Tammi Markku, Sironen Reijo, Soini Ylermi, Kosma Veli-Matti, Mannermaa Arto, Viikari Jukka, Tammi Raija. 2014. Breast cancer research and treatment. 143: 277-286 A1 Journal article (refereed), original research
Hyaluronan-coated extracellular vesicles - a novel link between hyaluronan and cancer
Rilla Kirsi, Siiskonen Hanna, Tammi Markku, Tammi Raija. 2014. Advances in cancer research. 123: 121-148 A2 Review article, Literature review, Systematic review
Rab10-mediated endocytosis of the hyaluronan synthase HAS3 regulates hyaluronan synthesis and cell adhesion to collagen
Deen Ashik Jawahar, Rilla Kirsi, Oikari Sanna, Kärnä Riikka, Bart Genevieve, Häyrinen Jukka, Bathina Avinash Rahul, Ropponen Antti, Makkonen Katri, Tammi Raija H, Tammi Markku I. 2014. Journal of biological chemistry. 289: 8375-89 A1 Journal article (refereed), original research
Aneuploidy facilitates oncogenic transformation via specific genetic alterations, including Twist2 upregulation
Högnäs G, Hämälistö S, Rilla K, Laine JO, Vilkki V, Murumägi A, Edgren H, Kallioniemi O, Ivaska J. 2013. Carcinogenesis. Epub: e1-10 A1 Journal article (refereed), original research
Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells
Viiri J, Amadio M, Marchesi N, Hyttinen JM, Kivinen N, Sironen R, Rilla K, Akhtar S, Provenzani A, D'Agostino VG, Govoni S, Pascale A, Agostini H, Petrovski G, Salminen A, Kaarniranta K. 2013. PLoS ONE. 8: e6963, 16 pages A1 Journal article (refereed), original research
Donor simvastatin treatment prevents ischemia-reperfusion and acute kidney injury by preserving microvascular barrier function
Tuuminen R, Nykänen AI, Saharinen P, Gautam P, Keränen MA, Arnaudova R, Rouvinen E, Helin H, Tammi R, Rilla K, Krebs R, Lemström KB. 2013. American journal of transplantation. 13: 2019-34 A1 Journal article (refereed), original research
Hyaluronan production enhances shedding of plasma membrane-derived microvesicles
Rilla K, Pasonen-Seppänen S, Deen AJ, Koistinen VVT, Wojciechowski S, Oikari S, Kärnä R, Bart G, Törrönen K, Tammi RH, Tammi MI. 2013. Experimental cell research. 319: 2006-2018 A1 Journal article (refereed), original research
Hyaluronan synthase 1 (HAS1) produces a cytokine- and glucose-inducible, CD44-dependent cell surface coat
Siiskonen H, Kärnä R, Hyttinen JM, Tammi RH, Tammi MI, Rilla K. 2013. Experimental cell research. online: - A1 Journal article (refereed), original research
Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GIcNAc concentration than HAS2 and HAS3
Rilla K, Oikari S, Jokela TA, Hyttinen JMT, Kärnä R, Tammi RH, Tammi MI. 2013. Journal of biological chemistry. 288: 5973-5983 A1 Journal article (refereed), original research
Mannose reduces hyaluronan and leukocytes in wound granulation tissue and inhibits migration and hyaluronan-dependent monocyte binding
Jokela TA, Kuokkanen J, Kärnä R, Pasonen-Seppänen S, Rilla K, Kössi J, Laato M, Tammi RH, Tammi MI. 2013. Wound repair and regeneration. 21: 247-255 A1 Journal article (refereed), original research
Re-evaluation of the role of P-glycoprotein in in vitro drug permeability studies with the bovine brain microvessel endothelial cells
Hakkarainen Jenni J, Rilla Kirsi, Suhonen Marjukka, Ruponen Marika, Forsberg Markus M. 2013. Xenobiotica. 2014:44: 283-294 A1 Journal article (refereed), original research
Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes
Törrönen K, Nikunen K, Kärnä R, Tammi M, Tammi R, Rilla K. 2013. Histochemistry and cell biology. 140: - A1 Journal article (refereed), original research
Amine Surface Modifications and Fluorescent Labeling of Thermally Stabilized Mesoporous Silicon Nanoparticles
Xu Wujun, Riikonen Joakim, Nissinen Tuomo, Suvanto Mika, Rilla Kirsi, Li Bojie, Wang Qiang, Deng Feng, Lehto Vesa-Pekka. 2012. Journal of physical chemistry c. 116: 22307-22314 A1 Journal article (refereed), original research
Hyaluronan in cytosol - microinjection-based probing of its existence and suggested functions
Siiskonen H, Rilla K, Kärnä R, Bart G, Jing W, Haller MF, DeAngelis PL, Tammi RH, Tammi MI. 2012. Glycobiology. online: - A1 Journal article (refereed), original research
Melanoma cell-derived factors stimulate hyaluronan in dermal fibroblasts by upregulating HAS2 through PDGFR-PI3K_AKT and p38 -signaling
Pasonen-Seppänen S, Takabe P, Edward M, Rauhala L, Rilla K, Tammi M, Tammi R. 2012. Histochemistry and cell biology. 138: 895-911 A1 Journal article (refereed), original research
Role of CD44 in the organization of keratinocyte pericellular hyaluronan
Pasonen-Seppänen S, Hyttinen JM, Rilla K, Jokela T, Noble PW, Tammi M, Tammi R. 2012. Histochemistry and cell biology. 137: 107-120 A1 Journal article (refereed), original research
Chronic UVR Causes Increased Immunostaining of CD44 and Accumulation of Hyaluronan in Mouse Epidermis
Siiskonen Hanna, Törrönen Kari, Kumlin Timo, Rilla Kirsi, Tammi Markku I, Tammi Raija H. 2011. Journal of histochemistry and cytochemistry. 59: 908-917 A1 Journal article (refereed), original research
HAS3-induced accumulation of hyaluronan in 3D MDCK cultures results in mitotic spindle misorientation and disturbed organization of epithelium
Rilla Kirsi, Pasonen-Seppänen Sanna, Kärnä Riikka, Karjalainen Hannu M, Törrönen Kari, Koistinen Ville, Tammi Markku I, Tammi Raija H, Teräväinen Terhi, Manninen Aki. 2011. Histochemistry and cell biology. 137: 153-164 A1 Journal article (refereed), original research
Transcriptional and post-translational regulation of hyaluronan synthesis
Tammi Raija H, Passi Alberto G, Rilla Kirsi, Karousou Evgenia, Vigetti Davide, Makkonen Katri, Tammi Markku I. 2011. Febs journal. 278: 1- 10 A1 Journal article (refereed), original research
Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma
Nykopp TK, Rilla K, Tammi MI, Tammi RH, Sironen R, Hämäläinen K, Kosma V-M, Heinonen S & Anttila M. 2010. Bmc cancer. 10: 512 A1 Journal article (refereed), original research
Methyl-&#946 -cyclodetextrin suppresses hyaluronan synthesis by down-regulation of hyaluronan synthase 2 through inhibition of Akt
Kultti A, Kärnä R, Rilla K, Nurminen P, Koli E, Makkonen KM, Si J, Tammi MI & Tammi R. 2010. Journal of biological chemistry. 285: 22901-22910 A1 Journal article (refereed), original research
Microvillus - a hyaluronan synthesizing organelle
Rilla Kirsi, Tammi Markku, Tammi Raija. 2010. Trends in Cell & Molecular Biology. 5: 1-8 A1 Journal article (refereed), original research
The enigma of hyaluronan-synthesizing membrane protrusions and hyaluronan coats
Rilla K, Tammi M & Tammi R. 2010. GlycoForum. HA35: 1-10 A1 Journal article (refereed), original research
p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells
Viiri J, Hyttinen JMT, Ryhänen T, Rilla K, Paimela T, Kuusisto E, Siitonen A, Urtti A, Salminen A & Kaarniranta K. 2010. Molecular vision. 16: 1399-1414 A1 Journal article (refereed), original research
4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3
Kultti A, Pasonen-Seppänen S, Jauhiainen Marjo, Rilla KJ, Kärnä R, Pyöriä E, Tammi RH, Tammi MI. 2009. Experimental cell research. 315: 1914-1923 A1 Journal article (refereed), original research
Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYALI and hyaluronan content
Nykopp TK, Rilla K, Sironen R, Tammi MI, Tammi RH, Hämäläinen K, Heikkinen A-M, Komulainen M, Kosma V-M, Anttila M. 2009. Bmc cancer. 9: [9 p.] A1 Journal article (refereed), original research
Induction of hyaluronan cables and monocyte adherence in epidermal keratinocytes
Jokela TA, Lindgren A, Rilla K, Maytin E, Hascall VC, Tammi RH, Tammi MI. 2008. Connective tissue research. 49: 115-119 A1 Journal article (refereed), original research
Pericellular hyaluronan coat visualized in live cells with a fluorescent probe is scaffolded by plasma membrane protrusions
Rilla K, Tiihonen R, Kultti A, Tammi M, Tammi R. 2008. Journal of histochemistry and cytochemistry. 56: 901-910 A1 Journal article (refereed), original research
Solunetti - biotieteitä verkossa (www.solunetti.fi)
Törrönen K, Rilla K. 2008. Solubiologi. 26: 16-19 D1 Article in a trade journal
Hyaluronan Synthase. Intracellular Traffic, Activity at Plasma Membrane, and Impact on Keratinocyte Micration, Proliferation and Formation of Microvilli
Rilla K. 2006. Kuopio University Publications D. Medical Sciences G5 Doctoral dissertation (article)
Hyaluronan synthesis induces microvillus-like cell surface protrusions
Kultti A, Rilla K, Tiihonen R, Spicer AP, Tammi R, Tammi M. 2006. Journal of biological chemistry. 281: 15821-15828 A1 Journal article (refereed), original research
4-methylumbelliferone inhibits hyaluronan synthesis, proliferation and migration by suppressing hyaluronan synthase 2 and 3 messenger RNA levels in breast cancer cells
Kultti A, Rilla K, Törrönen K, MacDonald J, Tammi R, Tammi M. Teoksessa: Balazs EA, Hascall VC(toim.) , 2005. Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications. Hyaluronan 2003. s. 283-287. Matrix Biology Institute A4 Conference proceedings
Hyaluronan and CD44 in epidermal activation
Tammi M, Törrönen K, Pasonen-Seppänen S, Karvinen S, Rilla K, Pienimäki J-P, Tammi R. Teoksessa: Balazs EA, Hascall VC(toim.) , 2005. Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications. Hyaluronan 2003.. s. 641-647. Matrix Biology Institute A4 Conference proceedings
Hyaluronan size dependent migration and mitogen activated protein kinase signalling in human keratinocytes
Törrönen K, Rilla K, Tammi R, Tammi M. Teoksessa: Balazs EA, Hascall VC(toim.) , 2005. Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications. s. 649-653. Matrix Biology Institute A4 Conference proceedings
Iho tarvitsee hyaluronaania
Rilla K, Tammi R. 2005. Solubiologi. 23: 10-15 A1 Journal article (refereed), original research
Plasma membrane residence of hyaluronan synthase is coupled to its entzymatic activity
Rilla K, Siiskonen H, Spicer AP, Hyttinen JMT, Tammi MI, Tammi RH. 2005. Journal of biological chemistry. 280: 31890-31897 A1 Journal article (refereed), original research
Suppression of hyaluronan synthesis by 4-methylumbelliferone retards keratinocyte migration and proliferation
Rilla K, Hyttinen JMT, Törrönen K, Pasonen-Seppänen S, Heldin P, Spicer AP, Rieppo J, Mättö M, Tammi M, Tammi R. Teoksessa: Balazs EA, Hascall VC(toim.) , 2005. Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications. Hyaluronan 2003.. s. 637-640. Matrix Biology Institute A4 Conference proceedings
The hyaluronan synthesis inhibitor 4-methylumbelliferone prevents keratinocyte activation and epidermal hyperproliferation induced by epidermal growth factor
Rilla K, Pasonen-Seppänen S, Rieppo J, Tammi M, Tammi R. 2004. Journal of investigative dermatology. 123: 708-714 A1 Journal article (refereed), original research
Changed lamellipodial extension, adhesion plaques and migration in epidermal keratinocytes containing constitutively expressed sense and antisense hyaluronan synthase 2 (Has2) genes
Rilla K, Lammi MJ, Sironen R, Törrönen K, Luukkonen M, Hascall VC, Midura RJ, Hyttinen M, Pelkonen J, Tammi M, Tammi R. 2002. Journal of cell science. 115: 3633-3643 A1 Journal article (refereed), original research
EGF regulates HAS2 expression, controls epidermal thickness and stimulates keratinocyte migration
Tammi MI, Pienimäki J-P, Rilla K, Fülöp C, Lammi MJ, Sironen R, Midura R, Hascall VC, Luukkonen M, Törrönen K, Lehto T, Tammi R. Teoksessa: Kennedy JF, Phillips GO, Williams PA, Hascall VC(toim.) , 2002. Hyaluronan. Chemical, Biochemical and Biological Aspects.. s. 561-570. Woodhead A3 Book section, Chapters in research books
Hyaluronan stimulates keratinocyte migration and activates the transcription factor AP-1 in keratinocytes through the JNK pathway
Törrönen K, Yabal M, Rilla K, Kaarniranta K, Tammi R, Lammi MJ, Tammi M. Teoksessa: Kennedy JF, Phillips GO, Williams PA, Hascall VC(toim.) , 2002. Hyaluronan. Chemical, Biochemical and Biological Aspects.. s. 551-556. Woodhead A3 Book section, Chapters in research books
Hyaluronan synthase 2 (HAS2) regulates migration of epidermal keratinocytes
Rilla K, Lammi M, Sironen R, Hascall VC, Midura R, Tammi M, Tammi R. Teoksessa: Kennedy JF, Phillips GO, Williams PA, Hascall VC(toim.) , 2002. Hyaluronan. Chemical, Biochemical and Biological Aspects. s. 557-560. Woodhead A3 Book section, Chapters in research books
Intracellular hyaluronan in epidermal keratinocytes
Tammi R, Rilla K, Pienimäki J-P, Hogg M, MacCallum DK, Hascall VC, Tammi M. Teoksessa: Kennedy JF, Phillips GO, Williams PA, Hascall VC(toim.) , 2002. Hyaluronan. Chemical, Biochemical and Biological Aspects. s. 517-524. Woodhead A3 Book section, Chapters in research books
Epidermal growth factor activates hyaluronan synthase 2 in epidermal keratinocytes and increases pericellular and intracellular hyaluronan
Pienimäki J-P, Rilla K, Csaba F, Sironen RK, Karvinen S, Pasonen S, Lammi MJ, Tammi R, Hascall VC, Tammi MI. 2001. Journal of biological chemistry. 276: 20428-20435 A1 Journal article (refereed), original research
Hyaluronan enters keratinocytes by a novel endocytic route for catabolism
Tammi R, Rilla K, Pienimäki J-P, MacCallum DK, Hogg M, Luukkonen M, Hascall VC, Tammi M. 2001. Journal of biological chemistry. 276: 35111-35122 B1 Non-refereed journal articles

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Kirsi Rilla

Research groups

Projects

DPYSL5 is highly expressed in treatment-induced neuroendocrine prostate cancer and promotes lineage plasticity via EZH2/PRC2

Development of Focused Ultrasound-Assisted Nanoplexes for RNA Delivery

EP300/CREBBP acetyltransferase inhibition limits steroid receptor and FOXA1 signaling in prostate cancer cells

Increased secretion of adipocyte-derived extracellular vesicles is associated with adipose tissue inflammation and the mobilization of excess lipid in human obesity

PL3 CendR peptide shows specific uptake in cultured Y79 retinoblastoma cells with nucleolar accumulation

Selective drug delivery to the retinal cells: Biological barriers and avenues

The Hyaluronan-Rich Zones of Plasma Membrane Protrusions and Extracellular Vesicles

The prognostic and predictive role of tumor-infiltrating lymphocytes (FoxP3 + and CD8 +) and tumor-associated macrophages in early HER2 + breast cancer

A quick pipeline for the isolation of 3D cell culture‐derived extracellular vesicles

Counts of hyaluronic acid-containing extracellular vesicles decrease in naturally occurring equine osteoarthritis

Fatty Acid Fingerprints and Hyaluronic Acid in Extracellular Vesicles from Proliferating Human Fibroblast-like Synoviocytes

Isolation of Extracellular Vesicles From the Bronchoalveolar Lavage Fluid of Healthy and Asthmatic Horses

MCF10CA Breast Cancer Cells Utilize Hyaluronan-Coated EV-Rich Trails for Coordinated Migration

Microscopic characterization reveals the diversity of EVs secreted by GFP-HAS3 expressing MCF7 cells

Neuron-astrocyte transmitophagy is altered in Alzheimer's disease

Advanced nanoengineered - customized point-of-care tools for prostate-specific antigen

Characterization of hyaluronan-coated extracellular vesicles in synovial fluid of patients with osteoarthritis and rheumatoid

Diverse plasma membrane protrusions act as platforms for extracellular vesicle shedding

Enhanced gene expression by a novel designed leucine zipper endosomolytic peptide

Nano-enabled strategies to combat methicillin-resistant Staphylococcus aureus

The power of imaging to understand extracellular vesicle biology in vivo

High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils

Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism

Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aß

The density and length of filopodia associate with the activity of hyaluronan synthesis in tumor cells

The prognostic and predictive role of the neutrophil-to-lymphocyte ratio and the monocyte-to-lymphocyte ratio in early breast cancer, especially in the HER2+ subtype

Activated hyaluronan metabolism in the tumor matrix - Causes and consequences

CD44s Assembles Hyaluronan Coat on Filopodia and Extracellular Vesicles and Induces Tumorigenicity of MKN74 Gastric Carcinoma Cells

Correlative light and electron microscopy is a powerful tool to study interactions of extracellular vesicles with recipient cells

Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2)

Extracellular vesicles are integral and functional components of the extracellular matrix

HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells

Hyaluronan histochemistry - A potential new tool to assess the progress of liver disease from simple steatosis to hepatocellular carcinoma

Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters

Tumor microenvironment and breast cancer survival: combined effects of breast fat, M2 macrophages and hyaluronan create a dismal prognosis

Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas

Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death

EMT induced by EGF and wounding activates hyaluronan synthesis machinery and EV shedding in rat primary mesothelial cells

Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles

Metastatic state of parent cells influences the uptake and functionality of prostate cancer cell-derived extracellular vesicles

Molecular targets of chloropicrin in human airway epithelial cells

Ekstrasellulaarivesikkelit tulevaisuuden biomarkkereina

First in vivo detection and characterization of hyaluronan-coated extracellular vesicles in human synovial fluid

High extent of O-GlcNAcylation in breast cancer cells correlates with the levels of HAS enzymes, accumulation of hyaluronan, and poor outcome

Hyaluronan-positive plasma membrane protrusions exist on mesothelial cells in vivo

Mesotheliomas show higher hyaluronan positivity around tumor cells than metastatic pulmonary adenocarcinomas

UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression

Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia

Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles

High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation

Hyaluronan synthase 1: a mysterious enzyme with unexpected functions

Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion

Interleukin-1ß-induced Reduction of CD44 Ser-325 Phosphorylation in Human Epidermal Keratinocytes Promotes CD44 Homomeric Complexes, Binding to Ezrin, and Extended, Monocyte-adhesive Hyaluronan Coats

Chloropicrin-induced toxic responses in human lung epithelial cells

Chondrocytic cells express the taurine transporter on their plasma membrane and regulate its expression under anisotonic conditions

Correlative light and electron microscopy reveals the morphological changes of HAS3 overexpressing breast cancer cells and their hyaluronan-dependent plasma membrane protrusions

Extensive CD44-dependent hyaluronan coats on human bone marrow-derived mesenchymal stem cells produced by hyaluronan synthases HAS1, HAS2 and HAS3

High numbers of macrophages, especially M2-like (CD163-positive), correlate with hyaluronan accumulation and poor outcome in breast cancer

Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival

Hyaluronan-coated extracellular vesicles - a novel link between hyaluronan and cancer

Rab10-mediated endocytosis of the hyaluronan synthase HAS3 regulates hyaluronan synthesis and cell adhesion to collagen

Aneuploidy facilitates oncogenic transformation via specific genetic alterations, including Twist2 upregulation

Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells

Donor simvastatin treatment prevents ischemia-reperfusion and acute kidney injury by preserving microvascular barrier function

Hyaluronan production enhances shedding of plasma membrane-derived microvesicles

Hyaluronan synthase 1 (HAS1) produces a cytokine- and glucose-inducible, CD44-dependent cell surface coat

Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GIcNAc concentration than HAS2 and HAS3

Mannose reduces hyaluronan and leukocytes in wound granulation tissue and inhibits migration and hyaluronan-dependent monocyte binding

Re-evaluation of the role of P-glycoprotein in in vitro drug permeability studies with the bovine brain microvessel endothelial cells

Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes

Amine Surface Modifications and Fluorescent Labeling of Thermally Stabilized Mesoporous Silicon Nanoparticles

Hyaluronan in cytosol - microinjection-based probing of its existence and suggested functions

Melanoma cell-derived factors stimulate hyaluronan in dermal fibroblasts by upregulating HAS2 through PDGFR-PI3K_AKT and p38 -signaling

Role of CD44 in the organization of keratinocyte pericellular hyaluronan

Chronic UVR Causes Increased Immunostaining of CD44 and Accumulation of Hyaluronan in Mouse Epidermis