Lilian Fernandes Silva

Genome-wide characterization of circulating metabolic biomarkers

Karjalainen, Minna K.; Karthikeyan, Savita; Oliver-Williams, Clare; Sliz, Eeva; Allara, Elias; Fung, Wing Tung; Surendran, Praveen; Zhang, Weihua; Jousilahti, Pekka; Kristiansson, Kati; Salomaa, Veikko; Goodwin, Matt; Hughes, David A.; Boehnke, Michael; Fernandes Silva, Lilian; Yin, Xianyong; Mahajan, Anubha; Neville, Matt J.; van Zuydam, Natalie R.; de Mutsert, Renée; Li-Gao, Ruifang; Mook-Kanamori, Dennis O.; Demirkan, Ayse; Liu, Jun; Noordam, Raymond; Trompet, Stella; Chen, Zhengming; Kartson. 2024. Nature. [Epub ahead of print 06 March 2024]: 1-21

Relationships and Mendelian Randomization of Gut Microbe-Derived Metabolites with Metabolic Syndrome Traits in the METSIM Cohort

Mirzaei, Sahereh; DeVon, Holli A; Cantor, Rita M; Cupido, Arjen J; Pan, Calvin; Ha, Sung Min; Silva, Lilian Fernandes; Hilser, James R; Hartiala, Jaana; Allayee, Hooman; Rey, Federico E; Laakso, Markku; Lusis, Aldons J. 2024. Metabolites. 14:

A cross-ancestry genome-wide meta-analysis, fine-mapping, and gene prioritization approach to characterize the genetic architecture of adiponectin

Sarsani, Vishal; Brotman, Sarah M; Xianyong, Yin; Fernandes Silva, Lillian; Laakso, Markku; Spracklen, Cassandra N. 2023. HGG advances. 2024; 5:

Cell-type composition affects adipose gene expression associations with cardiometabolic traits

Brotman, Sarah M; Oravilahti, Anniina; Rosen, Jonathan D; Alvarez, Marcus; Heinonen, Sini; van der Kolk, Birgitta; Silva, Lilian Fernandes; Perrin, Hannah J; Vadlamudi, Swarooparani; Pylant, Cortney; Deochand, Sonia; Basta, Patricia V; Valone, Jordan M; Narain, Morgan N; Stringham, Heather M; Boehnke, Michael; Kuusisto, Johanna; Love, Michael I; Pietiläinen, Kirsi H; Pajukanta, Päivi; Laakso, Markku; Mohlke, Karen L. 2023. Diabetes. 72: 1707-1718

Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood

Hawkes, Gareth; Beaumont, Robin N; Tyrrell, Jessica; Power, Grace M; Wood, Andrew; Laakso, Markku; Silva, Lilian Fernandes; Boehnke, Michael; Yin, Xianyong; Richardson, Tom G; Smith, George Davey; Frayling, Timothy M. 2023. Diabetologia. 66: 1472-1480

Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

Williamson, Alice; Norris, Dougall M.; Yin, Xianyong; Broadaway, K. Alaine; Moxley, Anne H.; Vadlamudi, Swarooparani; Wilson, Emma P.; Jackson, Anne U.; Ahuja, Vasudha; Andersen, Mette K.; Arzumanyan, Zorayr; Bonnycastle, Lori L.; Bornstein, Stefan R.; Bretschneider, Maxi P.; Buchanan, Thomas A.; Chang, Yi-Cheng; Chuang, Lee-Ming; Chung, Ren-Hua; Clausen, Tine D.; Damm, Peter; Delgado, Graciela E.; de Mello, Vanessa D.; Dupuis, Josée; Dwivedi, Om P.; Erdos, Michael R.; Silva, Lilian Fernandes; F. 2023. Nature genetics. 55: 973-983

Loci for insulin processing and secretion provide insight into type 2 diabetes risk

Broadaway, K. Alaine; Yin, Xianyong; Williamson, Alice; Parsons, Victoria A.; Wilson, Emma P.; Moxley, Anne H.; Vadlamudi, Swarooparani; Varshney, Arushi; Jackson, Anne U.; Ahuja, Vasudha; Bornstein, Stefan R.; Corbin, Laura J.; Delgado, Graciela E.; Dwivedi, Om P.; Fernandes Silva, Lilian; Frayling, Timothy M.; Grallert, Harald; Gustafsson, Stefan; Hakaste, Liisa; Hammar, Ulf; Herder, Christian; Herrmann, Sandra; Højlund, Kurt; Hughes, David A.; Kleber, Marcus E.; Lindgren, Cecilia M.; Liu, Chi. 2023. American journal of human genetics. 110: 284-299

Metabolites as Risk Factors for Diabetic Retinopathy in Patients with Type 2 Diabetes: a 12-year Follow-up Study

Fernandes Silva, Lilian; Hokkanen, Jenna; Vangipurapu, Jagadish; Oravilahti, Anniina; Laakso, Markku. 2023. Journal of clinical endocrinology and metabolism. 2024; 109: 100–106

Plasma Metabolite Signatures in Male Carriers of Genetic Variants Associated with Non-Alcoholic Fatty Liver Disease

Fernandes Silva, Lilian; Vangipurapu, Jagadish; Oravilahti, Anniina; Männistö, Ville; Laakso, Markku. 2023. Metabolites. 13:

Effects of SLCO1B1 Genetic Variant on Metabolite Profile in Participants on Simvastatin Treatment

Fernandes Silva, Lilian; Ravi, Rowmika; Vangipurapu, Jagadish; Oravilahti, Anniina; Laakso, Markku. 2022. Metabolites. 12:

Genetics of Type 2 Diabetes: Past, Present, and Future

Laakso, Markku; Fernandes Silva, Lilian. 2022. Nutrients. 14: . 3201

Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci

Yin, Xianyong; Chan, Lap Sum; Bose, Debraj; Jackson, Anne U; VandeHaar, Peter; Locke, Adam E; Fuchsberger, Christian; Stringham, Heather M; Welch, Ryan; Yu, Ketian; Fernandes Silva, Lilian; Service, Susan K; Zhang, Daiwei; Hector, Emily C; Young, Erica; Ganel, Liron; Das, Indraniel; Abel, Haley; Erdos, Michael R; Bonnycastle, Lori L; Kuusisto, Johanna; Stitziel, Nathan O; Hall, Ira M; Wagner, Gregory R; Ripatti, Samuli; Palotie, Aarno; Kang, Jian; Morrison, Jean; Burant, Charles F; Collins, Fran. 2022. Nature communications. 13: . 1644

Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk

Yin, Xianyong; Bose, Debraj; Kwon, Annie; Hanks, Sarah C.; Jackson, Anne U.; Stringham, Heather M.; Welch, Ryan; Oravilahti, Anniina; Fernandes Silva, Lilian; Locke, Adam E.; Fuchsberger, Christian; Service, Susan K.; Erdos, Michael R.; Bonnycastle, Lori L.; Kuusisto, Johanna; Stitziel, Nathan O.; Hall, Ira M.; Morrison, Jean; Ripatti, Samuli; Palotie, Aarno; Freimer, Nelson B.; Collins, Francis S.; Mohlke, Karen L.; Scott, Laura J.; Fauman, Eric B.; Burant, Charles; Boehnke, Michael; Laakso, Ma. 2022. American journal of human genetics. 109: 1727-1741

Metabolite Signature in the Carriers of Pathogenic Genetic Variants for Cardiomyopathy: A Population-Based METSIM Study

Ravi, Rowmika; Fernandes Silva, Lilian; Vangipurapu, Jagadish; Maria, Maleeha; Raivo, Joose; Helisalmi, Seppo; Laakso, Markku. 2022. Metabolites. 12:

Metabolite Signature of Physical Activity and the Risk of Type 2 Diabetes in 7271 Men

Kemppainen, Susanna Maria; Silva, Lilian Fernandes; Lankinen, Maria Anneli; Schwab, Ursula; Laakso, Markku. 2022. Metabolites. 12:

Metabolite Signature of Simvastatin Treatment Involves Multiple Metabolic Pathways

Fernandes Silva, Lilian; Ravi, Rowmika; Vangipurapu, Jagadish; Laakso, Markku. 2022. Metabolites. 12:

The "Common Soil Hypothesis" Revisited - Risk Factors for Type 2 Diabetes and Cardiovascular Disease

Fernandes Silva, Lilian; Vangipurapu, Jagadish; Laakso, Markku. 2021. Metabolites. 11: 691

The Obesity Risk SNP (rs17782313) near the MC4R Gene Is Not Associated with Brain Glucose Uptake during Insulin Clamp-A Study in Finns

Rebelos, Eleni; Honka, Miikka-Juhani; Ekblad, Laura; Bucci, Marco; Hannukainen, Jarna C; Fernandes Silva, Lilian; Virtanen, Kirsi A; Nummenmaa, Lauri; Nuutila, Pirjo. 2021. Journal of clinical medicine. 10: 1312

Metabolite signature of albuminuria involves amino acid pathways in 8,661 Finnish men without diabetes

Fernandes Silva, Lilian; Vangipurapu, Jagadish; Smith, Ulf; Laakso, Markku. 2020. Journal of clinical endocrinology and metabolism. 2021; 106: 143-152

Microbiota-Related Metabolites and the Risk of Type 2 Diabetes

Vangipurapu, Jagadish; Fernandes Silva, Lilian; Kuulasmaa, Teemu; Smith, Ulf; Laakso, Markku. 2020. Diabetes care. 43: 1319-1325

Phenotypic characterization of genetic variants associated with the risk of type 2 diabetes and non-alcoholic fatty liver disease

Fernandes Silva, Lilian. 2020. Publications of the University of Eastern Finland. Dissertations in Health Sciences

An intronic variant in the GCKR gene is associated with multiple lipids

Fernandes, Silva L; Vangipurapu, J; Kuulasmaa, T; Laakso, M. 2019. Scientific reports. 9: 10240

Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia

López Rodríguez, Maykel; Fernandes Silva, Lilian; Vangipurapu, Jagadish; Modi, Shalem; Kuusisto, Johanna; Kaikkonen, Minna U; Laakso, Markku. 2018. Scientific reports. 8: 15989

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Lilian Fernandes Silva

Genome-wide characterization of circulating metabolic biomarkers

Relationships and Mendelian Randomization of Gut Microbe-Derived Metabolites with Metabolic Syndrome Traits in the METSIM Cohort

A cross-ancestry genome-wide meta-analysis, fine-mapping, and gene prioritization approach to characterize the genetic architecture of adiponectin

Cell-type composition affects adipose gene expression associations with cardiometabolic traits

Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood

Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

Loci for insulin processing and secretion provide insight into type 2 diabetes risk

Metabolites as Risk Factors for Diabetic Retinopathy in Patients with Type 2 Diabetes: a 12-year Follow-up Study

Plasma Metabolite Signatures in Male Carriers of Genetic Variants Associated with Non-Alcoholic Fatty Liver Disease

Effects of SLCO1B1 Genetic Variant on Metabolite Profile in Participants on Simvastatin Treatment

Genetics of Type 2 Diabetes: Past, Present, and Future

Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci

Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk

Metabolite Signature in the Carriers of Pathogenic Genetic Variants for Cardiomyopathy: A Population-Based METSIM Study

Metabolite Signature of Physical Activity and the Risk of Type 2 Diabetes in 7271 Men

Metabolite Signature of Simvastatin Treatment Involves Multiple Metabolic Pathways

The "Common Soil Hypothesis" Revisited - Risk Factors for Type 2 Diabetes and Cardiovascular Disease

The Obesity Risk SNP (rs17782313) near the MC4R Gene Is Not Associated with Brain Glucose Uptake during Insulin Clamp-A Study in Finns

Metabolite signature of albuminuria involves amino acid pathways in 8,661 Finnish men without diabetes

Microbiota-Related Metabolites and the Risk of Type 2 Diabetes

Phenotypic characterization of genetic variants associated with the risk of type 2 diabetes and non-alcoholic fatty liver disease

An intronic variant in the GCKR gene is associated with multiple lipids

Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia