Lilian Fernandes Silva
Tutkijatohtori
Apulaisprofessori (Dosentti) metabolisairauksissa
Kliinisen lääketieteen yksikkö, Lääketieteen laitos, Terveystieteiden tiedekunta
I am a researcher in the field of precision medicine at the Department of Internal Medicine at the University of Eastern Finland and a fellow researcher at the David Geffen School of Medicine, UCLA
. My research focuses on the identification and characterization of metabolites associated with metabolic diseases, especially understanding metabolic pathways in different physiological states such as normal glucose tolerance, prediabetes and type 2 diabetes, utilizing advanced metabolomics and clinical data. My goal is to develop individualized approaches to the early detection and treatment of metabolic disorders, promoting the development of precision medicine in metabolic diseases. With a strong background in pharmacy, I combine biochemical expertise with clinical insights, helping to interpret findings into potential therapeutic interventions.
Avainsanat
Julkaisut
26/26 kappaletta-
Genome-wide characterization of circulating metabolic biomarkers
Karjalainen, Minna K.; Karthikeyan, Savita; Oliver-Williams, Clare; Sliz, Eeva; Allara, Elias; Fung, Wing Tung; Surendran, Praveen; Zhang, Weihua; Jousilahti, Pekka; Kristiansson, Kati; Salomaa, Veikko; Goodwin, Matt; Hughes, David A.; Boehnke, Michael; Fernandes Silva, Lilian; Yin, Xianyong; Mahajan, Anubha; Neville, Matt J.; van Zuydam, Natalie R.; de Mutsert, Renée; Li-Gao, Ruifang; Mook-Kanamori, Dennis O.; Demirkan, Ayse; Liu, Jun; Noordam, Raymond; Trompet, Stella; Chen, Zhengming; Kartson. 2024. Nature. 628: 130-138 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Gut microbe-derived metabolites and the risk of cardiovascular disease in the METSIM cohort
Mirzaei, Sahereh; DeVon, Holli A; Cantor, Rita M.; Cupido, Arjen; Fernandes Silva, Lilian; Laakso, Markku; Lusis, Aldons J. 2024. Frontiers in microbiology. 15: . 1411328 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Metabolomics-Based Machine Learning for Predicting Mortality: Unveiling Multisystem Impacts on Health
Oravilahti, Anniina; Vangipurapu, Jagadish; Laakso, Markku; Fernandes Silva, Lilian. 2024. International journal of molecular sciences. 25: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Novel Metabolites Associated with Decreased GFR in Finnish Men: A 12-Year Follow-Up of the METSIM Cohort
Fernandes Silva, Lilian; Vangipurapu, Jagadish; Oravilahti, Anniina; Laakso, Markku. 2024. International journal of molecular sciences. 25: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Relationships and Mendelian Randomization of Gut Microbe-Derived Metabolites with Metabolic Syndrome Traits in the METSIM Cohort
Mirzaei, Sahereh; DeVon, Holli A; Cantor, Rita M; Cupido, Arjen J; Pan, Calvin; Ha, Sung Min; Silva, Lilian Fernandes; Hilser, James R; Hartiala, Jaana; Allayee, Hooman; Rey, Federico E; Laakso, Markku; Lusis, Aldons J. 2024. Metabolites. 14: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
A cross-ancestry genome-wide meta-analysis, fine-mapping, and gene prioritization approach to characterize the genetic architecture of adiponectin
Sarsani, Vishal; Brotman, Sarah M; Xianyong, Yin; Fernandes Silva, Lillian; Laakso, Markku; Spracklen, Cassandra N. 2023. HGG advances. 2024; 5: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Cell-type composition affects adipose gene expression associations with cardiometabolic traits
Brotman, Sarah M; Oravilahti, Anniina; Rosen, Jonathan D; Alvarez, Marcus; Heinonen, Sini; van der Kolk, Birgitta; Silva, Lilian Fernandes; Perrin, Hannah J; Vadlamudi, Swarooparani; Pylant, Cortney; Deochand, Sonia; Basta, Patricia V; Valone, Jordan M; Narain, Morgan N; Stringham, Heather M; Boehnke, Michael; Kuusisto, Johanna; Love, Michael I; Pietiläinen, Kirsi H; Pajukanta, Päivi; Laakso, Markku; Mohlke, Karen L. 2023. Diabetes. 72: 1707-1718 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood
Hawkes, Gareth; Beaumont, Robin N; Tyrrell, Jessica; Power, Grace M; Wood, Andrew; Laakso, Markku; Silva, Lilian Fernandes; Boehnke, Michael; Yin, Xianyong; Richardson, Tom G; Smith, George Davey; Frayling, Timothy M. 2023. Diabetologia. 66: 1472-1480 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
Williamson, Alice; Norris, Dougall M.; Yin, Xianyong; Broadaway, K. Alaine; Moxley, Anne H.; Vadlamudi, Swarooparani; Wilson, Emma P.; Jackson, Anne U.; Ahuja, Vasudha; Andersen, Mette K.; Arzumanyan, Zorayr; Bonnycastle, Lori L.; Bornstein, Stefan R.; Bretschneider, Maxi P.; Buchanan, Thomas A.; Chang, Yi-Cheng; Chuang, Lee-Ming; Chung, Ren-Hua; Clausen, Tine D.; Damm, Peter; Delgado, Graciela E.; de Mello, Vanessa D.; Dupuis, Josée; Dwivedi, Om P.; Erdos, Michael R.; Silva, Lilian Fernandes; F. 2023. Nature genetics. 55: 973-983 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Loci for insulin processing and secretion provide insight into type 2 diabetes risk
Broadaway, K. Alaine; Yin, Xianyong; Williamson, Alice; Parsons, Victoria A.; Wilson, Emma P.; Moxley, Anne H.; Vadlamudi, Swarooparani; Varshney, Arushi; Jackson, Anne U.; Ahuja, Vasudha; Bornstein, Stefan R.; Corbin, Laura J.; Delgado, Graciela E.; Dwivedi, Om P.; Fernandes Silva, Lilian; Frayling, Timothy M.; Grallert, Harald; Gustafsson, Stefan; Hakaste, Liisa; Hammar, Ulf; Herder, Christian; Herrmann, Sandra; Højlund, Kurt; Hughes, David A.; Kleber, Marcus E.; Lindgren, Cecilia M.; Liu, Chi. 2023. American journal of human genetics. 110: 284-299 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä