Maria Pikkarainen

Obesity and Brain Vulnerability in Normal and Abnormal Aging: A Multimodal MRI Study

Dake, Manmohi D; De Marco, Matteo; Blackburn, Daniel J; Wilkinson, Iain D; Remes, Anne; Liu, Yawu; Pikkarainen, Maria; Hallikainen, Merja; Soininen, Hilkka; Venneri, Annalena. 2021. Journal of Alzheimer's disease reports. 5: 65-77

Metabolic Profiles Help Discriminate Mild Cognitive Impairment from Dementia Stage in Alzheimer's Disease.

Jääskeläinen, O; Hall, A; Tiainen, M; van Gils, M; Lötjönen, J; Kangas, AJ; Helisalmi, S; Pikkarainen, M; Hallikainen, M; Koivisto, A; Hartikainen, P; Hiltunen, M; Ala-Korpela, M; Soininen, P; Soininen, H; Herukka, S-K. 2020. Journal of Alzheimer's disease. 74: 277-286

White Matter Hyperintensities are No Major Confounder for Alzheimer's Disease Cerebrospinal Fluid Biomarkers

van Waalwijk van Doorn, Linda J C; Ghafoorian, Mohsen; van Leijsen, Esther M C; Claassen, Jurgen A H R; Arighi, Andrea; Bozzali, Marco; Cannas, Jorge; Cavedo, Enrica; Eusebi, Paolo; Farotti, Lucia; Fenoglio, Chiara; Fortea, Juan; Frisoni, Giovanni B; Galimberti, Daniela; Greco, Viviana; Herukka, Sanna-Kaisa; Liu, Yawu; Lleó, Alberto; de Mendonça, Alexandre; Nobili, Flavio M; et al. [incl. Pikkarainen, Maria; Soininen, Hilkka]. 2020. Journal of Alzheimer's disease. 2021; 79: 163-175

cCOG: A web-based cognitive test tool for detecting neurodegenerative disorders

Rhodius-Meester, HFM; Paajanen, T; Koikkalainen, J; Mahdiani, S; Bruun, M; Baroni, M; Lemstra, AW; Scheltens, P; Herukka, SK; Pikkarainen, M; Hall, A; Hänninen, T; Ngandu, T; Kivipelto, M; van Gils, M; Hasselbalch, SG; Mecocci, P; Remes, A; Soininen, H; van der Flier, WM; Lötjönen, J. 2020. Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 12: e12083

Low Serum High-Density Lipoprotein Cholesterol Levels Associate with the C9orf72 Repeat Expansion in Frontotemporal Lobar Degeneration Patients

Jääskeläinen, O; Solje, E; Hall, A; Katisko, K; Korhonen, V; Tiainen, M; Kangas, AJ; Helisalmi, S; Pikkarainen, M; Koivisto, A; Hartikainen, P; Hiltunen, M; Ala-Korpela, M; Soininen, H; Soininen, P; Haapasalo, A; Remes, AM; Herukka, SK. 2019. Journal of Alzheimer's disease. 72: 127-137

Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study

Reijs BLR, Vos SJB, Soininen H, Lötjonen J, Koikkalainen J, Pikkarainen M, Hall A, Vanninen R, Liu Y, Herukka SK, Freund-Levi Y, Frisoni GB, Frölich L, Nobili F, Rikkert MO, Spiru L, Tsolaki M, Wallin ÅK, Scheltens P1, Verhey F, Visser PJ. 2017. Journal of Alzheimer's disease. 60: 1387-1395

Hippocampal Sclerosis and Epilepsy in Elderly Population

Rauramaa Tuomas, Solomon Alina, Pikkarainen Maria, Kälviäinen Reetta, Alafuzoff Irina. 2017. Journal of Alzheimer's disease & Parkinsonism. 7: 384

Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes

van Waalwijk van Doorn LC, Gispert JD, Kuiperij HB, Claassen, JAHR, Arighi A, Baldeiras I, Blennow K, Bozzali M, Castelo-Branco M, Cavedo E, Emek-Savas D, Eren E, Eusebi P, Farotti L, Fenoglio C, Ormaechea JF, Freund-Levi Y, Frisoni G, Galimberti D, Genc S et al. 2017. Journal of Alzheimer's disease. 56: 543-555

The Modified Frontal Behavioral Inventory (FBI-mod) for Patients with Frontotemporal Lobar Degeneration, Alzheimer's Disease, and Mild Cognitive Impairment

Suhonen NM, Hallikainen I, Hänninen T, Jokelainen J, Krüger J, Hall A, Pikkarainen M, Soininen H, Remes AM. 2017. Journal of Alzheimer's disease. 56: 1241-1251

The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology

Westwood S, Liu B, Baird AL, Anand S, Nevado-Holgado AJ, Newby D, Pikkarainen M, Hallikainen M, Kuusisto J, Streffer JR, Novak G, Blennow K, Andreasson U, Zetterberg H, Smith U, Laakso M, Soininen H, Lovestone S. 2017. Alzheimer's research and therapy. 9: 31

Biological confounders for the values of cerebrospinal fluid proteins in Parkinson's disease and related disorders

Mollenhauer Brit, Parnetti Lucilla, Rektorova Irena, Kramberger Milica G, Pikkarainen Maria, Schulz-Schaeffer Walter J, Aarsland Dag, Svenningsson Per, Farotti Lucia, Verbeek Marcel M, Schlossmacher Michael G. 2016. Journal of neurochemistry. 139: 290-317

Alzheimer's disease: a report from the 7th Kuopio Alzheimer symposium

Haapasalo Annakaisa, Pikkarainen Maria, Soininen Hilkka. 2015. Neurodegenerative disease management. 5: 379-382

Chasing the effects of pre-analytical confounders - a multicenter study on CSF-AD biomarkers

Leitão Maria João, Baldeiras Inês, Herukka Sanna-Kaisa, Pikkarainen Maria, Leinonen Ville, Simonsen Anja Hviid, Perret-Liaudet Armand, Fourier Anthony, Quadrio Isabelle, Veiga Pedro Mota, de Oliveira Catarina Resende. 2015. Frontiers in neurology. 6: 153

Erratum to: Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium (vol 122, pg 957, 2015)

Alafuzoff Irina, Pikkarainen Maria, Neumann Manuela, Arzberger Thomas, Al-Sarraj Safa, Bodi Istvan, Bogdanovic Nenad, Bugiani Orso, Ferrer Isidro, Gelpi Ellen, Gentleman Stephen, Giaccone Giorgio, Graeber Manuel B., Hortobagyi Tibor, Ince Paul G., Ironside James W., Kavantzas Nikolaos, King Andrew, Korkolopoulou Penelope, Kovacs Gabor G. et al.. 2015. Journal of neural transmission. 122: 973-974

Synucleinopathies

Alafuzoff Irina, Pikkarainen Maria, Parkkinen Laura. Teoksessa: Kovacs Gabor G(toim.) , 2015. Neuropathology of Neurodegenerative Diseases: A Practical Guide. s. 149-175. Cambridge University Press

Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium

Alafuzoff I, Pikkarainen M, Neumann M, Arzberger T, Al-Sarraj S, Bodi I, Bogdanovic N, Bugiani O, Ferrer I, Gelpi E, Gentleman S, Giaccone G, Graeber MB, Hortobagyi T, Ince PG, Ironside JW, Kavantzas N, King A, Korkolopoulou P, Kovács GG, et al.. 2014. Journal of neural transmission. 2014: 1-16; Published online: 20 September 2014

Consensus recommendations on pathologic changes in the hippocampus: A postmortem multicenter inter-rater study

Rauramaa T, Pikkarainen M, Englund E, Ince PG, Jellinger K, Paetau A, Alafuzoff I. 2013. Journal of neuropathology and experimental neurology. 72: 452-461

GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients

Kämäläinen A, Viswanathan J, Natunen T, Helisalmi S, Kauppinen T, Pikkarainen M, Pursiheimo J-P, Alafuzoff I, Kivipelto M, Haapasalo A, Soininen H, Herukka S-K, Hiltunen M. 2013. Journal of Alzheimer's disease. 33: 23-27

An antibody with high reactivity for disease-associated alfa-synuclein reveals extensive brain pathology

Kovacs G, Wagner U, Dumont B, Pikkarainen M, Osman AA, Streichenberger N, Leisser I, Verchere J, Baron T, Alafuzoff I, Budka H, Perret-Liaudet A, Lachmann I. 2012. Acta neuropathologica. 124: 37-50

Unusual clinical presentation and neuropathology in two subjects with fused-in sarcoma (FUS) positive inclusions

Hartikainen PH, Pikkarainen M, Hänninen T, Soininen H, Alafuzoff I. 2012. Neuropathology. 32: 60-68

Cardiovascular diseases and hippocampal infarcts

Rauramaa T, Pikkarainen M, Englund E, Ince PG, Jellinger K, Paetau A, Parkkinen L, Alafuzoff I. 2011. Hippocampus. 21: 281-287

Distribution and pattern of pathology in subjects with familial or sporadic late-onset cerebellar Ataxia as assessed by p62/Sequestosome immunohistochemistry

Pikkarainen M, Hartikainen P, Soininen H, Alafuzoff I. 2011. Cerebellum. 10: 720-731

TAR-DNA binding protein-43 and anterations in the hippocampus

Rauramaa T, Pikkarainen M, Englund E, Ince PG, Jellinger K, Paetau A, Alafuzoff I. 2011. Journal of neural transmission. 118: 683-689

Brain pathology in three subjects from the same pedigree with presenilin-1 (PSEN1) P264L mutation

Martikainen P, Pikkarainen M, Pöntynen K, Hiltunen M, Lehtovirta M, Tuisku S, Soininen H & Alafuzoff I. 2010. Neuropathology and applied neurobiology. 36: 41-54

Immunohistochemical visualization of amyloid-beta protein precursor and amyloid-beta in extra- and intracellular compartments in the human brain

Aho L, Pikkarainen M, Hiltunen M, Leinonen V, Alafuzoff I. 2010. Journal of Alzheimer's disease. 20: 1015-1028

The effect of prolonged fixation time on immunohistochemical staining of common neurodegenerative disease markers

Pikkarainen M, Martikainen P & Alafuzoff I. 2010. Journal of neuropathology and experimental neurology. 69: 40-52

Ubiquitinated p62-positive, TDP-43-negative inclusions in cerebellum in frontotemporal lobar degeneration with TAR DNA binding protein 43

Pikkarainen M, Hartikainen P & Alafuzoff I. 2010. Neuropathology. 30: 197-199

Assessment of beta-amyloid deposits in human brain: a study of the BrainNet Europe Consortium

Alafuzoff I, Thal DR, Arzberger T, Bogdanovic N, Ala-sarraj S, Bodi I, Boluda S, Bugiani O, Duyckaerts C, Gelpi E..., Pikkarainen M, Revesz T.... 2009. Acta neuropathologica. 117: 309-320

Expression of collagen XVII and ubiquitin-binding protein p62 in motor neuron disease

Seppänen A, Pikkarainen M, Hartikainen P, Hofmann SC, Majamaa K, Alafuzoff I. 2009. Brain research. 1247: 171-177

Hyperphosphorylated Tau in the occipital cortex in aged nondemented subjects

Pikkarainen M, Kauppinen T, Alafuzoff I. 2009. Journal of neuropathology and experimental neurology. 68: 653-660

Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions visualized with ubiquitin-binding protein p62 immunohistochemistry

Pikkarainen M, Hartikainen P, Alafuzoff I. 2008. Journal of neuropathology and experimental neurology. 67: 280-298

Interlaboratory comparison of assessments of Alzheimer disease-related lesions: a study of the BrainNet Europe consortium

Alafuzoff I, Pikkarainen M, Al-Sarraj S, Arzberger T, Bell J, Bodi I, Bogdanovic N, Budka H, Bugiani O, Ferrer I, Gelpi E, Giaccone G, ... et al.. 2006. Journal of neuropathology and experimental neurology. 65: 740-757

Projections from the amygdaloid complex to the claustrum and the endopiriform nucleus: a Phaseolus vulgaris leucoagglutinin study in the rat

Majak K, Pikkarainen M, Kemppainen S, Jolkkonen E, Pitkänen A. 2002. Journal of comparative neurology. 451: 236-249

Projections from the amygdaloid complex to the magnocellular cholinergic basal forebrain in rat

Jolkkonen E, Miettinen R, Pikkarainen M, Pitkänen A. 2002. Neuroscience. 111: 133-149

Interconnectivity between the amygdaloid complex and the amygdalostriatal transition area: a PHA-L study in rat

Jolkkonen E, Pikkarainen M, Kemppainen S, Pitkänen A. 2001. Journal of comparative neurology. 431: 39-58

Projections from the lateral, basal and accessory basal nuclei of the amygdala to the perirhinal and postrhinal cortices in rat

Pikkarainen M, Pitkanen A. 2001. Cerebral cortex. 11: 1064-1082

The Rat Parahippocampal Region. Chemoarchitectonics and Afferent Connections from the Amygdala with Special Emphasis on the Entorhinal Cortex

Pikkarainen M. 2001. Kuopion yliopiston julkaisuja C. Luonnontieteet ja ympäristötieteet

Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat: a review

Pitkänen A, Pikkarainen M, Nurminen N, Ylinen A. 2000. Annals of the New York Academy of Sciences. 911: 369-391

Projections from the lateral, basal, and accessory basal nuclei of the amygdala to the hippocampal formation in rat

Pikkarainen M, Rönkkö S, Savander V, Insausti R, Pitkänen A. 1999. Journal of comparative neurology. 403: 229-260

Distribution of calretinin-immunoreactivity in the rat entorhinal cortex:coexistence with GABA

Miettinen M, Pitkänen A, Miettinen R. 1997. Journal of comparative neurology. 378: 363-378

Coexistence of parvalbumin and GABA in nonpyramidal neurons of the rat entorhinal cortex

Miettinen M, Koivisto E, Riekkinen P Sr, Miettinen R. 1996. Brain research. 706: 113-122

Research groups

Projects

Obesity and Brain Vulnerability in Normal and Abnormal Aging: A Multimodal MRI Study

Metabolic Profiles Help Discriminate Mild Cognitive Impairment from Dementia Stage in Alzheimer's Disease.

White Matter Hyperintensities are No Major Confounder for Alzheimer's Disease Cerebrospinal Fluid Biomarkers

cCOG: A web-based cognitive test tool for detecting neurodegenerative disorders

Low Serum High-Density Lipoprotein Cholesterol Levels Associate with the C9orf72 Repeat Expansion in Frontotemporal Lobar Degeneration Patients

Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study

Hippocampal Sclerosis and Epilepsy in Elderly Population

Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes

The Modified Frontal Behavioral Inventory (FBI-mod) for Patients with Frontotemporal Lobar Degeneration, Alzheimer's Disease, and Mild Cognitive Impairment

The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology

Biological confounders for the values of cerebrospinal fluid proteins in Parkinson's disease and related disorders

Alzheimer's disease: a report from the 7th Kuopio Alzheimer symposium

Chasing the effects of pre-analytical confounders - a multicenter study on CSF-AD biomarkers

Erratum to: Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium (vol 122, pg 957, 2015)

Synucleinopathies

Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium

Consensus recommendations on pathologic changes in the hippocampus: A postmortem multicenter inter-rater study

GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients

An antibody with high reactivity for disease-associated alfa-synuclein reveals extensive brain pathology

Unusual clinical presentation and neuropathology in two subjects with fused-in sarcoma (FUS) positive inclusions

Cardiovascular diseases and hippocampal infarcts

Distribution and pattern of pathology in subjects with familial or sporadic late-onset cerebellar Ataxia as assessed by p62/Sequestosome immunohistochemistry

TAR-DNA binding protein-43 and anterations in the hippocampus

Brain pathology in three subjects from the same pedigree with presenilin-1 (PSEN1) P264L mutation

Immunohistochemical visualization of amyloid-beta protein precursor and amyloid-beta in extra- and intracellular compartments in the human brain

The effect of prolonged fixation time on immunohistochemical staining of common neurodegenerative disease markers

Ubiquitinated p62-positive, TDP-43-negative inclusions in cerebellum in frontotemporal lobar degeneration with TAR DNA binding protein 43

Assessment of beta-amyloid deposits in human brain: a study of the BrainNet Europe Consortium

Expression of collagen XVII and ubiquitin-binding protein p62 in motor neuron disease

Hyperphosphorylated Tau in the occipital cortex in aged nondemented subjects

Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions visualized with ubiquitin-binding protein p62 immunohistochemistry

Interlaboratory comparison of assessments of Alzheimer disease-related lesions: a study of the BrainNet Europe consortium

Projections from the amygdaloid complex to the claustrum and the endopiriform nucleus: a Phaseolus vulgaris leucoagglutinin study in the rat

Projections from the amygdaloid complex to the magnocellular cholinergic basal forebrain in rat

Interconnectivity between the amygdaloid complex and the amygdalostriatal transition area: a PHA-L study in rat

Projections from the lateral, basal and accessory basal nuclei of the amygdala to the perirhinal and postrhinal cortices in rat

The Rat Parahippocampal Region. Chemoarchitectonics and Afferent Connections from the Amygdala with Special Emphasis on the Entorhinal Cortex

Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat: a review

Projections from the lateral, basal, and accessory basal nuclei of the amygdala to the hippocampal formation in rat

Distribution of calretinin-immunoreactivity in the rat entorhinal cortex:coexistence with GABA

Coexistence of parvalbumin and GABA in nonpyramidal neurons of the rat entorhinal cortex