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Marjut Roponen

Marjut Roponen

Deputy Head of Department

Professor

Toxicology of environmental exposures

Department of Environmental and Biological Sciences, Faculty of Science, Forestry and Technology

marjut.roponen@uef.fi | +358 40 356 2521

Information Publications

My research focuses on the early-life environmental exposure, immune development and the risk of allergic diseases. I also study how climate change affects pollen allergenicity factors and the prevalence of allergic diseases in Finland. I have specialized in immunotoxicology and -epidemiology.

Research groups

Inhalation Toxicology Laboratory 01.01.2010 -

Keywords

air pollution childhood asthma environmental exposure environmental health immunology immunotoxicology inhalation toxicology

Publications

96/96 items

An integrated molecular risk score early in life for subsequent childhood asthma risk
Böck, Andreas; Urner, Kathrin; Eckert, Jana Kristin; Salvermoser, Michael; Laubhahn, Kristina; Kunze, Sonja; Kumbrink, Jörg; Hoeppner, Marc P; Kalkbrenner, Kathrin; Kreimeier, Simone; Beyer, Kirsten; Hamelmann, Eckard; Kabesch, Michael; Depner, Martin; Hansen, Gesine; Riedler, Josef; Roponen, Marjut; Schmausser‐Hechfellner, Elisabeth; Barnig, Cindy; Divaret‐Chauveau, Amandine; Karvonen, Anne M; Pekkanen, Juha; Frei, Remo; Roduit, Caroline; Lauener, Roger; Schaub, Bianca; CHAMP study group; PASTU. 2024. Clinical and experimental allergy. 54: 314-328
Immune modulation by rural exposures and allergy protection
Xing, Yuhan; Tsang, Miranda Sin‐Man; Yang, Zhaowei; Wang, Maggie Haitian; Pivniouk, Vadim; Leung, Agnes Sze‐Yin; Leung, Ting‐Fan; Roponen, Marjut; Schaub, Bianca; Vercelli, Donata; Wong, Chun‐Kwok; Li, Jing; Wong, Gary Wing‐Kin. 2024. Pediatric allergy and immunology. 35: . e14086
Impact of rising CO2 and temperature on grass phenology, physiology, and pollen release patterns in northern latitudes
Tossavainen, Tarleena; Kivimäenpää, Minna; Martikainen, Maria Viola; Leskinen, Ari; Heinonen, Tiina; Pessi, Anna Mari; Louna-Korteniemi, Maria; Pätsi, Sanna; Komppula, Mika; Saarto, Annika; Roponen, Marjut. 2024. Environmental and experimental botany. 228: . 105995
Sources of PM2.5 exposure misclassification in three Finnish register-based study populations and the impact on attenuation of health effect estimates
Korhonen, Antti; Rumrich, Isabell Katharina; Roponen, Marjut; Frohn, Lise M.; Geels, Camilla; Brandt, Jørgen; Tolppanen, Anna-Maija; Hänninen, Otto. 2024. Science of the total environment. 954:
Toxicological evaluation and concentration of airborne PM0.1 in high air pollution period in Guangzhou, China
Yang, Mo; Wu, Qi-Zhen; Zhang, Yun-Ting; Leskinen, Ari; Wang, Xin-Feng; Komppula, Mika; Hakkarainen, Henri; Roponen, Marjut; Jin, Nan-Xiang; Tan, Wei-Hong; Xu, Shu-Li; Lin, Li-Zi; Liu, Ru-Qing; Zeng, Xiao-Wen; Dong, Guang-Hui; Jalava, Pasi I. 2024. Science of the total environment. 921:
Cattle farm dust alters cytokine levels in human airway construct model
Martikainen, Maria-Viola; Huttunen, Kati; Tossavainen, Tarleena; Nordberg, Maria-Elisa; Roponen, Marjut. 2023. Toxicology in vitro. 88:
Common Pollen Modulate Immune Responses against Viral-Like Challenges in Airway Coculture Model
Tossavainen, Tarleena; Martikainen, Maria-Viola; Loukola, Hanna; Roponen, Marjut. 2023. Journal of immunology research. 2023:
Continuous rather than solely early farm exposure protect from hay fever development
Pechlivanis, Sonali; Depner, Martin; Kirjavainen, Pirkka V; Roduit, Caroline; Täubel, Martin; Frei, Remo; Skevaki, Chrysanthi; Hose, Alexander; Barnig, Cindy; Schmausser-Hechfellner, Elisabeth; Ege, Markus J; Schaub, Bianca; Divaret-Chauveau, Amandine; Lauener, Roger; Karvonen, Anne M; Pekkanen, Juha; Riedler, Josef; Illi, Sabina; von Mutius, Erika. 2023. Journal of allergy and clinical immunology : in practice. 11: 591-601
Development of an Integrated Exposure Pathway Model for Health Impact Assessment of Traffic Ultrafine Particles (H2020 Ultrhas-Project)
Korhonen, Antti; Lehtomäki, Heli; Rumrich, Isabell; Roponen, Marjut; Bølling, Anette; Aasvang, Gunn Marit; Jalava, Pasi; Rothen-Rutishauser, Barbara; Bucchianico, Sebastiano Di; Zimmermann, Ralf; Øvrevik, Johan; Hänninen, Otto. 2023. Annals of work exposures and health
Sources, chemical components, and toxicological responses of size segregated urban air PM samples in high air pollution season in Guangzhou, China
Yang, Mo; Zeng, Hui-Xian; Wang, Xin-Feng; Hakkarainen, Henri; Leskinen, Ari; Komppula, Mika; Roponen, Marjut; Wu, Qi-Zhen; Xu, Shu-Li; Lin, Li-Zi; Liu, Ru-Qing; Hu, Li-Wen; Yang, Bo-Yi; Zeng, Xiao-Wen; Dong, Guang-Hui; Jalava, Pasi. 2023. Science of the total environment. 865: 161092
Suomalaisten pienhiukkasaltistuksen kehitys 1979-2021
Hänninen, Otto; Korhonen, Antti; Lehtomäki, Heli; Roponen, Marjut, Rumrich, Isabell. 2023. Ilmansuojelu. 1: 19-23
Concentration, chemical composition and toxicological responses of the ultrafine fraction of urban air particles in PM1
Yang, Mo; Wu, Qi Zhen; Zhang, Yun Ting; Leskinen, Ari; Komppula, Mika; Hakkarainen, Henri; Roponen, Marjut; Xu, Shu Li; Lin, Li Zi; Liu, Ru Qing; Hu, Li Wen; Yang, Bo Yi; Zeng, Xiao Wen; Dong, Guang Hui; Jalava, Pasi. 2022. Environment international. 170: . 107661
Fine and ultrafine airborne PM influence inflammation response of young adults and toxicological responses in vitro
Yang, Mo; Jalava, Pasi; Hakkarainen, Henri; Roponen, Marjut; Leskinen, Ari; Komppula, Mika; Dong, Guo-Ping; Lao, Xiang-Qian; Wu, Qi-Zhen; Xu, Shu-Li; Lin, Li-Zi; Liu, Ru-Qing; Hu, Li-Wen; Yang, Bo-Yi; Zeng, Xiao-Wen; Dong, Guang-Hui. 2022. Science of the total environment. 836:
Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers
Illi, S; Depner, M; Pfefferle, PI; Renz, H; Roduit, C; Taft, DH; Kalanetra, KM; Mills, DA; Farquharson, FM; Louis, P; Schmausser-Hechfellner, E; Divaret-Chauveau, A; Lauener, R; Karvonen, AM; Pekkanen, J; Kirjavainen, PV; Roponen, M; Riedler, J; Kabesch, M; Schaub, B; von Mutius, E; PASTURE Study Group. 2022. American journal of respiratory and critical care medicine. 205: 641-650
Pollen, respiratory viruses, and climate change: Synergistic effects on human health
Martikainen, Maria-Viola; Tossavainen, Tarleena; Hannukka, Noora; Roponen, Marjut. 2022. Environmental research. 2023; 219:
Poultry exposure and environmental protection against asthma in rural children
Xing, Yuhan; Wang, Maggie H; Leung, Ting‐Fan; Wong, Chun‐Kwok; Roponen, Marjut; Schaub, Bianca; Li, Jing; Wong, Gary W K. 2022. Allergy. 77: 2949-2960
Raskaudenaikainen altistuminen ilmansaasteille
Korhonen, Antti; Rumrich, Isabell; Roponen, Marjut; Hänninen, Otto. 2022. Ilmansuojelu. 1: 10-13
Rural environment reduces allergic inflammation by modulating the gut microbiota
Yang, Zhaowei; Chen, Zhong; Lin, Xinliu; Yao, Siyang; Xian, Mo; Ning, Xiaoping; Fu, Wanyi; Jiang, Mei; Li, Naijian; Xiao, Xiaojun; Feng, Mulin; Lian, Zexuan; Yang, Wenqing; Ren, Xia; Zheng, Zhenyu; Zhao, Jiefeng; Wei, Nili; Lu, Wenju; Roponen, Marjut; Schaub, Bianca; Wong, Gary W. K.; Su, Zhong; Wang, Charles; Li, Jing. 2022. Gut microbes. 14: . 2125733
Systematic design of cell membrane coating to improve tumor targeting of nanoparticles
Liu, Lizhi; Pan, Dingyi; Chen, Sheng; Martikainen, Maria-Viola; Kårlund, Anna; Ke, Jing; Pulkkinen, Herkko; Ruhanen, Hanna; Roponen, Marjut; Käkelä, Reijo; Xu, Wujun; Wang, Jie; Lehto, Vesa-Pekka. 2022. Nature communications. 13:
Winter and spring variation in sources, chemical components and toxicological responses of urban air particulate matter samples in Guangzhou, China
Yang, Mo; Jalava, Pasi; Wang, Xin-Feng; Bloom, Michael S.; Leskinen, Ari; Hakkarainen, Henri; Roponen, Marjut; Komppula, Mika; Wu, Qi-Zhen; Xu, Shu-Li; Lin, Li-Zi; Liu, Ru-Qing; Hu, Li-Wen; Yang, Bo-Yi; Zeng, Xiao-Wen; Yu, Yun-Jiang; Dong, Guang-Hui. 2022. Science of the total environment. 845:
Associations of Particulate Matter Sizes and Chemical Constituents with Blood Lipids: A Panel Study in Guangzhou, China
He, Zhi-Zhou; Guo, Peng-Yue; Xu, Shu-Li; Zhou, Yang; Jalaludin, Bin; Leskinen, Ari; Knibbs, Luke D; Heinrich, Joachim; Morawska, Lidia; Yim, Steve Hung-Lam; Bui, Dinh; Komppula, Mika; Roponen, Marjut; Hu, Liwen; Chen, Gongbo; Zeng, Xiao-Wen; Yu, Yunjiang; Yang, Bo-Yi; Dong, Guanghui. 2021. Environmental science and technology. 55: 5065-5075
Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles
Liu, Lizhi; Bai, Xuan; Martikainen, Maria-Viola; Kårlund, Anna; Roponen, Marjut; Xu, Wujun; Hu, Guoqing; Tasciotti, Ennio; Lehto, Vesa-Pekka. 2021. Nature communications. 12: 5726
Early age exposure to moisture and mould is related to FeNO at the age of 6 years
Tischer, Christina; Karvonen, Anne M; Kirjavainen, Pirkka V; Flexeder, Claudia; Roponen, Marjut; Hyvärinen, Anne; Renz, Harald; Frey, Urs Peter; Fuchs, Oliver; Pekkanen, Juha. 2021. Pediatric allergy and immunology. 32: 1226-1237
Mitogen-activated protein kinase signaling in childhood asthma development and environment-mediated protection
Theodorou, J; Nowak, E; Böck, A; Salvermoser, M; Beerweiler, C; Zeber, K; Kulig, P; Tsang, MS; Wong, CK; Wong, GWK; Roponen, M; Kumbrink, J; Alhamdan, F; Michel, F; Garn, H; Tosevski, V; Schaub, B. 2021. Pediatric allergy and immunology. 2022; 33: e13657
Short-Term Effects of Particle Size and Constituents on Blood Pressure in Healthy Young Adults in Guangzhou, China
Guo, Peng-Yue; He, Zhi-Zhou; Jalaludin, Bin; Knibbs, Luke D; Leskinen, Ari; Roponen, Marjut; Komppula, Mika; Jalava, Pasi; Hu, Li-Wen; Chen, Gongbo; Zeng, Xiao-Wen; Yang, Bo-Yi; Dong, Guang-Hui. 2021. Journal of the american heart association: Cardiovascular and cerebrovascular disease. 10: e019063
Short-Term Effects of Particle Sizes and Constituents on Blood Biomarkers among Healthy Young Adults in Guangzhou, China
Feng, Dan; Cao, Ke; He, Zhi-Zhou; Knibbs, Luke D.; Jalaludin, Bin; Leskinen, Ari; Roponen, Marjut; Komppula, Mika; Jalava, Pasi; Guo, Peng-Yue; Xu, Shu-Li; Yang, Bo-Yi; Hu, Liwen; Zeng, Xiao-Wen; Chen, Gongbo; Yu, Hong-Yao; Lin, Lizi; Dong, Guanghui. 2021. Environmental science and technology. 55: 9
Toxicological and microbiological characterization of cow stable dust
Martikainen, Maria-Viola; Tossavainen, Tarleena; Täubel, Martin; Wolczkiewicz, Kirsi; Lähde, Anna; Roponen, Marjut. 2021. Toxicology in vitro. 75: 105202
Association Between Residential Greenness, Cardiometabolic Disorders, and Cardiovascular Disease Among Adults in China
Yang, Bo-Yi; Hu, Li-Wen; Jalaludin, Bin; Knibbs, Luke D; Markevych, Iana; Heinrich, Joachim; Bloom, Michael S; Morawska, Lidia; Lin, Shao; Jalava, Pasi; Roponen, Marjut; Gao, Meng; Chen, Duo-Hong; Zhou, Yang; Yu, Hong-Yao; Liu, Ru-Qing; Zeng, Xiao-Wen; Zeeshan, Mohammed; Guo, Yuming; Yu, Yunjiang et al.. 2020. JAMA network open. 3: e2017507
Cryopreservation Affected the Levels of Immune Responses of PBMCs and Antigen-Presenting Cells
Martikainen, Maria-Viola; Roponen, Marjut. 2020. Toxicology in vitro. 67: 104918
Greenness surrounding schools is associated with lower risk of asthma in schoolchildren.
Zeng, Xiao-Wen; Lowe, Adrian J; Lodge, Caroline J; Heinrich, Joachim; Roponen, Marjut; Jalava, Pasi; Guo, Yuming; Hu, Li-Wen; Yang, Bo-Yi; Dharmage, Shyamali C; Dong, Guang-Hui. 2020. Environment international. 143: 105967
Is PM 1 similar to PM 2.5? A new insight into the association of PM 1 and PM 2.5 with children's lung function
Yang, Mo; Guo, Yu-Ming; Bloom, Michael S; Dharmagee, Shyamali C; Morawska, Lidia; Heinrich, Joachim; Jalaludin, Bin; Markevychd, Iana; Knibbsf, Luke D; Lin, Shao; Hung Lan, Steve; Jalava, Pasi; Komppula, Mika; Roponen, Marjut; Hirvonen, Maija-Riitta; Guan, Qi-Hua; Liang, Zi-Mian; Yu, Hong-Yao; Hu, Li-Wen; Yang, Bo-Yi; et al.. 2020. Environment international. 145: 106092
Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma
Depner, Martin; Taft, Diana Hazard; Kirjavainen, Pirkka V; Kalanetra, Karen M; Karvonen, Anne M; Peschel, Stefanie; Schmausser-Hechfellner, Elisabeth; Roduit, Caroline; Frei, Remo; Lauener, Roger; Divaret-Chauveau, Amandine; Dalphin, Jean-Charles; Riedler, Josef; Roponen, Marjut; Kabesch, Michael; Renz, Harald; Pekkanen, Juha; Farquharson, Freda M; Louis, Petra; Mills, David A. et al.. 2020. Nature medicine. 26: 1766-1775
Modification of caesarean section on the associations between air pollution and childhood asthma in seven Chinese cities
Yu, Hongyao; Guo, Yuming; Zeng, Xiaoyun; Gao, Meng; Yang, Bo-Yi; Hu, Li-Wen; Yu, Yunjiang; Dong, Guang-Hui; Zhou, Yang; Qian, Zhengmin; Sun, Jia; McMillin, Stephen Edward; Bloom, Michael S; Heinrich, Joachim; Markevych, Iana; Morawska, Lidia; Dharmage, Shyamali C; Jalaludin, Bin; Knibbs, Luke; Lin, Shao; et al. [incl. Jalava, Pasi; Roponen, Marjut; Leskinen, Ari]. 2020. Environmental pollution. 267: 115443
Thermal dose as a universal tool to evaluate nanoparticle-induced photothermal therapy
Happonen, Emilia; Tamarov, Konstantin; Martikainen, Maria-Viola; Ketola, Kirsi; Roponen, Marjut; Lehto, Vesa-Pekka; Xu, Wujun. 2020. International journal of pharmaceutics. 587: 119657
Urban air PM modifies differently immune defense responses against bacterial and viral infections in vitro
Shahbaz, Muhammad Ali; Martikainen, Maria-Viola; Rönkkö, Teemu J; Komppula, Mika; Jalava, Pasi I; Roponen, Marjut. 2020. Environmental research. 192: 110244
Ambient Airborne Particulates of Diameter less than or equal to 1 micrometre, a Leading Contributor to the Association Between Ambient Airborne Particulates of Diameter less than or equal to 2.5 micrometres and Children's Blood Pressure
Wu, QZ; Li, S; Yang, BY; Bloom, M; Shi, Z; Knibbs, L; Dharmage, S; Leskinen, A; Jalaludin, B; Jalava, P; Roponen, M; Lin, S; Chen, G; Guo, Y; Xu, SL; Yu, HY; Zeeshan, M; Hu, LW; Yu, Y; Zeng, XW; et al.. 2019. Hypertension. 2020; 75: 347-355
Association between antibiotic treatment during pregnancy & infancy and the development of allergic diseases
Metzler, S; Frei, R; Schmaußer-Hechfellner, E; von Mutius, E; Pekkanen, J; Karvonen, AM; Kirjavainen, PV; Dalphin, JC; Divaret-Chauveau, A; Riedler, J; Lauener, R; Roduit, C; PASTURE/EFRAIM study group (incl. Roponen, Marjut). 2019. Pediatric allergy and immunology. 30: 423-433
Association of Breastfeeding and Air Pollution Exposure With Lung Function in Chinese Children
Zhang, C; Guo, Y; Xiao, X; Bloom, MS; Qian, Z; Rolling, CA; Xian, H; Lin, S; Li, S; Chen, G; Jalava, P; Roponen, M; Hirvonen, MR; Komppula, M; Leskinen, A; Yim, SHL; Chen, DH; Ma, H; Zeng, XW; Hu, LW; et al.. 2019. JAMA network open. 2: e194186
Benefits of influenza vaccination on the associations between ambient air pollution and allergic respiratory diseases in children and adolescents: New insights from the Seven Northeastern Cities study in China
Liu, Kangkang; Li, Shanshan; Qian, Zhengmin (Min); Dharmage, Shyamali C; Bloom, Michael S; Heinrich, Joachim; Jalaludin, Bin; Markevych, Iana; Morawska, Lidia; Knibbs, Luke D; Hinyard, Leslie; Xian, Hong; Liu, Shan; Lin, Shao; Leskinen, Ari; Komppula, Mika; Jalava, Pasi; Roponen, Marjut; Hu, Li-Wen; Zeng, Xiao-Wen; et al.. 2019. Environmental pollution. 2020; 256: 113434
Farm-like indoor microbiota in non-farm homes protects children from asthma development
Kirjavainen, PV; Karvonen, AM; Adams, RI; Täubel, M; Roponen, M; Tuoresmäki, P; Loss, G; Jayaprakash, B; Depner, M; Ege, MJ; Renz, H; Pfefferle, PI; Schaub, B; Lauener, R; Hyvärinen, A; Knight, R; Heederik, DJJ; von Mutius, E; Pekkanen, J. 2019. Nature medicine. 25: 1089-1095
Greenness around schools associated with lower risk of hypertension among children: Findings from the Seven Northeastern Cities Study in China
Xiao, Xiang; Yang, Bo-Yi; Markevych, Iana; Bloom, Michael S; Dharmage, Shyamali C; Jalaludin, Bin; Knibbs, Luke D; Heinrich, Joachim; Morawska, Lidia; Lin, Shao; Roponen, Marjut; Guo, Yuming; Hung Lam Yim, Steve; Leskinen, Ari; Komppula, Mika; Jalava, Pasi; Yu, Hong-Yao; Zeeshan, Mohammed; Zeng, Xiao-Wen; Dong, Guang-Hui. 2019. Environmental pollution. 2020; 256: 113422
Maatalomainen kodin mikrobisto voi suojata astmalta kaupungissakin
Kirjavainen, PV; Karvonen, AM; Adams, RI; Täubel, M; Roponen, M; Tuoresmäki, P; Loss, G; Jayaprakash, B; Depner, M; Ege, MJ; Renz, H; Pfefferle, PI; Schaub, B; Lauener, R; Hyvärinen, A; Knight, R; Heederik, DJJ; von Mutius, E; Pekkanen, J. 2019. Duodecim. 135: 1309
Parents know it best: Prediction of asthma and lung function by parental perception of early wheezing episodes
Brick, Tabea; Hose, Alexander; Wawretzka, Katharina; von Mutius, Erika; Roduit, Caroline; Lauener, Roger; Riedler, Josef; Karvonen, Anne M; Pekkanen, Juha; Divaret-Chauveau, Amandine; Dalphin, Jean-Charles; Ege, Markus J; PASTURE study group (incl. Roponen, Marjut; Hirvonen, Maija-Riitta; Kirjavainen, Pirkka Viljami). 2019. Pediatric allergy and immunology. 30: 795-802
Prenatal exposure to perfluoroalkyl substances is associated with lower hand, foot and mouth disease viruses antibody response in infancy: Findings from the Guangzhou Birth Cohort Study
Zeng, XW; Bloom, MS; Dharmage, SC; Lodge, CJ; Chen, D; Li, S; Guo, Y; Roponen, M; Jalava, P; Hirvonen, MR; Ma, H; Hao, YT; Chen, W; Yang, M; Chu, C; Li, QQ; Hu, LW; Liu, KK; Yang, BY; Liu, S; et al. 2019. Science of the total environment. 663: 60-67
TNF-α-induced protein 3 is a key player in childhood asthma development and environment-mediated protection
Krusche, Johanna; Twardziok, Monika; Rehbach, Katharina; Böck, Andreas; Tsang, Miranda S; Schröder, Paul C; Kumbrink, Jörg; Kirchner, Thomas; Xing, Yuhan; Riedler, Josef; Dalphin, Jean-Charles; Pekkanen, Juha; Lauener, Roger; Roponen, Marjut; Li, Jing; Wong, Chun K; Wong, Gary W K; Schaub, Bianca; Ege, Markus; Depner, Martin; et al.. 2019. Journal of allergy and clinical immunology. 144: 1684-1696.e12
A panel study of airborne particulate matter concentration and impaired cardiopulmonary function in young adults by two different exposure measurement
Hu, Li-Wen; Qian, Zhengmin (Min); Bloom, Michael S; Nelson, Erik J; Liu, Echu; Han, Bin; Zhang, Nan; Liu, Yimin; Ma, Huimin; Chen, Duo-Hong; Yang, Bo-Yi; Zeng, Xiao-Wen; Chen, Wen; Komppula, Mika; Leskinen, Ari; Hirvonen, Maija-Riitta; Roponen, Marjut; Jalava, Pasi; Bai, Zhipeng; Dong, Guang-Hui. 2018. Atmospheric environment. 180: 103-109
Early age exposure to moisture damage and systemic inflammation at the age of 6 years
Karvonen, AM; Tischer, C; Kirjavainen, PV; Roponen, M; Hyvärinen, A; Illi, S; Mustonen, K; Pfefferle, PI; Renz, H; Remes, S; Schaub, B; von Mutius, E; Pekkanen, J. 2018. Indoor air. 28: 450-458
High levels of Butyrate and Propionate in early life are associated with protection against atopy
Roduit, C; Frei, R; Ferstl, R; Loeliger, S; Westermann, P; Rhyner, C; Schiavi, E; Barcik, W; Rodriguez-Perez, N; Wawrzyniak, M; Chassard, C; Lacroix, C; Schmausser-Hechfellner, E; Depner, M; von Mutius, E; Braun-Fahrländer, C; Karvonen, A; Kirjavainen, P; Pekkanen, J; Dalphin, JC; et al. 2018. Allergy. 2019; 74: 799-809
Integrating farm and air pollution studies in search for immunoregulatory mechanisms operating in protective and high-risk environments
Martikainen, MV; Rönkkö, TJ; Schaub, B; Täubel, M; Gu, C; Wong, GW; Li, J; Pekkanen, J; Komppula, M; Hirvonen, MR; Jalava, PI; Roponen, M. 2018. Pediatric allergy and immunology. 29: 815-822
Is smaller worse? New insights about associations of PM1 and respiratory health in children and adolescents
Yang, M; Chu, C; Bloom, MS; Li, S; Chen, G; Heinrich, J; Markevych, I; Knibbs, LD; Bowatte, G; Dharmage, SC; Komppula, M; Leskinen, A; Hirvonen, MR; Roponen, M; Jalava, P; Wang, SQ; Lin, S; Zeng, XW; Hu, LW; Liu, KK; et al.. 2018. Environment international. 120: 516-524
Protective effects of breastfeeding on respiratory symptoms in infants with 17q21 asthma risk variants
Gorlanova, O; Illi, S; Toncheva, AA; Usemann, J; Latzin, P; Kabesch, M; Dalphin, JC; Lauener, R; Pekkanen, JR; Von Mutius, E; Riedler, J; Kuehni, CE; Röösli, M; Frey, U; et al.; BILD and PASTURE study groups (incl. Roponen, M). 2018. Allergy. 73: 2388-2392
Asthmatic farm children show increased CD3+CD8low T-cells compared to non-asthmatic farm children
Twardziok M, Schröder PC, Krusche J, Casaca VI, Illi S, Böck A, Loss GJ, Kabesch M, Toncheva A, Roduit C, Depner M, Genuneit J, Renz H, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Lauener R, Vuitton DA, Dalphin JC et al., the PASTURE Study Group. 2017. Clinical immunology. 183: 285-292
Exposure to nonmicrobial N-glycolylneuraminic acid protects farmers' children against airway inflammation and colitis
Frei Remo, Ferstl Ruth, Roduit Caroline, Ziegler Mario, Schiavi Elisa, Barcik Weronika, Rodriguez-Perez Noelia, Wirz Oliver F, Wawrzyniak Marcin, Pugin Benoit, Nehrbass Dirk, Jutel Marek, Smolinska Sylwia, Konieczna Patrycja, Bieli Christian, Loeliger Susanne, Waser Marco, Pershagen Göran, Riedler Josef, Depner Martin et al. (incl. Roponen Marjut, Hirvonen Marja-Riitta, Pekkanen Juha). 2017. Journal of allergy and clinical immunology. 2018; 141: 382-390.e7
Functional phenotypes determined by fluctuation-based clustering of lung function measurements in healthy and asthmatic cohort participants
Delgado-Eckert E, Fuchs O, Kumar N, Pekkanen J, Dalphin JC, Riedler J, Lauener R, Kabesch M, Kupczyk M, Dahlen SE, Mutius EV, Frey U et al., PASTURE Study group, BIOAIR Study group. 2017. Thorax. 2018; 73: 107-115
Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children
Zhou Y, Hu LW, Qian Z, Geiger SD, Parrish KL, Dharmage SC, Campbell B, Roponen M, Jalava P, Hirvonen MR, Heinrich J, Zeng XW, Yang BY, Qin XD, Lee YLL, Dong GH. 2017. Scientific reports. 7: 899
Latent class analysis reveals clinically relevant atopy phenotypes in two birth cohorts
Hose AJ, Depner M, Illi S, Lau S, Keil T, Wahn U, Fuchs O, Pfefferle PI, Schmaußer-Hechfellner E, Genuneit J, Lauener R, Karvonen AM, Roduit C, Dalphin JC, Riedler J, Pekkanen J, von Mutius E, Ege MJ, Bauer CP, Forster J et al., MAS and PASTURE Study Grops. 2017. Journal of allergy and clinical immunology. 139: 1935-1945.e12-
Phenotypes of atopic dermatitis depending on the timing of onset and progression in childhood
Roduit C, Frei R, Depner M, Karvonen AM, Renz H, Braun-Fahrländer C, Schmausser-Hechfellner E, Pekkanen J, Riedler J, Dalphin J-C, von Mutius E, Lauener RP and the PASTURE study group. 2017. JAMA pediatrics. 171: 655-662
The lack of natural processes of delivery and neonatal intensive care treatment lead to impaired cytokine responses later in life
Martikainen M-V, Keski-Nisula L, Jakupovic H, Karvonen AM, Pekkanen J, Hirvonen M-R, Roponen M. 2017. American journal of reproductive immunology. 77: -
A switch in regulatory T cells through farm-exposure during immune maturation in childhood
Schröder PC, Illi S, Casaca VI, Lluis A, Böck A, Roduit C, Depner M, Frei R, Genuneit J, Pfefferle PI, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Dalphin JC, Pekkanen J, Lauener R, von Mutius E, Schaub B, PASTURE study group (Hyvärinen A, Karvonen AM, Hirvonen MR, Tiittanen P, Remes S, Kaulek V, Dalphin ML, Ege MJ, Loss GJ, Renz H, Doekes G, Kabesch M). 2016. Allergy. [Epub ahead of print 17 Nov 2016]: -
Associations of Early Life Exposures and Environmental Factors With Asthma Among Children in Rural and Urban Areas of Guangdong, China
Feng M, Yang Z, Pan L, Lai X, Xian M, Huang X, Chen Y, Schröder PC, Roponen M, Schaub B, Wong GW, Li J. 2016. Chest. 149: 1030-1041
Enhanced T helper 1 and 2 cytokine responses at birth associate with lower risk of middle ear infections in infancy
Bergroth E, Roponen M, Karvonen AM, Keski-Nisula L, Remes S, Riedler J, Roduit C, Dalphin J-C, Kaulek V, Loss GJ, Lauener R, Hirvonen M-R, Genuneit J, Schmaußer-Hechfellner E, Renz H, Pfefferle PI, Krauss-Etschmann S, Schaub B, von Mutius E, Pekkanen J, the PASTURE study group. 2016. Pediatric allergy and immunology. 2017; 28: 53-59
IL-33 polymorphisms are associated with increased risk of hay fever and reduced regulatory T cells in a birth cohort
Schröder PC, Casaca VI, Illi S, Schieck M, Michel S, Böck A, Roduit C, Frei R, Lluis A, Genuneit J, Pfefferle P, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Lauener R, Vuitton DA, Dalphin J-C, Pekkanen J, von Mutius E et al.. 2016. Pediatric allergy and immunology. 27: 687-695
Maatila-altistuminen muokkaa lasten immuunivastetta sääteleviä mekanismeja
Martikainen Maria-Viola, Roponen Marjut. 2016. BestPractice Keuhkosairaudet: lääketieteen asiantuntijoiden ammattilehti. : 22-23
The Early Development of Wheeze: Environmental Determinants and Genetic Susceptibility at 17q21
Loss GJ, Depner M, Hose AJ, Genuneit J, Karvonen AM, Hyvärinen A, Roduit C, Kabesch M, Lauener R, Pfefferle PI, Pekkanen J, Dalphin JC, Riedler J, Braun-Fahrländer C, von Mutius E, Ege MJ, PASTURE study group (Dalphin M-L, Doekes G, Frei R, Hirvonen M-R, Illi S, Kaulek V, Schaub B, Remes S, Renz H, Roponen M, Tiittanen P). 2016. American journal of respiratory and critical care medicine. 193: 889-897
Circulating dendritic cells, farm exposure and asthma at early age
Kääriö Heidi, Nieminen Janne K, Karvonen Anne M, Huttunen Kati, Schröder Paul C, Vaarala Outi, von Mutius Erika, Pfefferle Petra Ina, Schaub Bianca, Pekkanen Juha, Hirvonen Maija-Riitta, Roponen Marjut. 2015. Scandinavian journal of immunology. 83 (2016): 18-25
Exposure to a farm environment is associated with Th1 and regulatory cytokines at age 4.5 years
Kääriö H, Huttunen K, Karvonen AM, Schaub B, von Mutius E, Pekkanen J, Hirvonen MR, Roponen M. 2015. Clinical and experimental allergy. 2016; 46: 71-77
Farm exposures are associated with lower percentage of circulating myeloid dendritic cell subtype 2 at age 6
Martikainen M-V, Kääriö H, Karvonen A Schröder PC, Renz H, Kaulek V, Dalphin J-C, von Mutius E, Schaub B, Pekkanen J, Hirvonen M-R, Roponen M. 2015. Allergy. 70: 1278-1287
High level of fecal calprotectin at age 2 months as a marker of intestinal inflammation predicts atopic dermatitis and asthma by age 6
Orivuori L, Mustonen K, de Goffau MC, Hakala S, Paasela M, Roduit C, Dalphin JC, Genuneit J, Lauener R, Riedler J, Weber J, von Mutius E, Pekkanen J, Harmsen HJ, Vaarala O, PASTURE Study Group (Hirvonen MR, Hyvärinen A, Karvonen AM, Remes S, Roponen M, Tiittanen P, Dalphin ML, Kaulek V, Depner M, Ege M, Illi S, Kabesch M, Pfefferle P, Renz H, Schaub B, Doekes G, Braun-Fahrländer C, Frei R, Loss G). 2015. Clinical and experimental allergy. 45: 928-939
Moisture damage in home associates with systemic inflammation in children
Mustonen K, Karvonen AM, Kirjavainen P, Roponen M, Schaub B, Hyvärinen A, Frey U, Renz H, Pfefferle PI, Genuneit J, Vaarala O, Pekkanen J. 2015. Indoor air. [epub ahead of print 23 May 2015]: -
Clinical and Epidemiologic Phenotypes of Childhood Asthma
Depner Martin, Fuchs Oliver, Genuneit Jon, Karvonen Anne M, Hyvärinen Anne, Kaulek Vincent, Roduit Caroline, Weber Juliane, Schaub Bianca, Lauener Roger, Kabesch Michael, Pfefferle Petra Ina, Frey Urs, Pekkanen Juha, Dalphin Jean-Charles, Riedler Joseph, Braun-Fahrländer Charlotte, von Mutius Erika, Ege Markus J and the PASTURE Study Group. 2014. American journal of respiratory and critical care medicine. 189: 129-138
Consumption of unprocessed cow's milk protects infants from common respiratory infections
Loss Georg, Depner Martin, Ulfman Laurien H, van Neerven RJ Joost, Hose Alexander J, Genuneit Jon, Karvonen Anne M, Hyvärinen Anne, Kaulek Vincent, Roduit Caroline, Weber Juliane, Lauener Roger, Pfefferle Petra Ina, Pekkanen Juha, Vaarala Outi, Dalphin Jean-Charles, Riedler Josef, Braun-Fahrländer Charlotte, von Mutius Erika, Ege Markus J. and the PASTURE study group. 2014. Journal of allergy and clinical immunology. 135: 56-62.E2
Determinants, reproducibility, and seasonal variation of bacterial cell wall components and viable counts in house dust
Leppänen HK, Täubel M, Roponen M, Vepsäläinen A, Rantakokko P, Pekkanen J, Nevalainen A, von Mutius E, Hyvärinen A.. 2014. Indoor air. 2015; 25: 260-272
Immunoglobulin A and immunoglobulin G antibodies against ß-lactoglobulin and gliadin at age 1 associate with immunoglobulin E sensitization at age 6
Orivuori L, Loss G, Roduit C, Dalphin JC, Depner M, Genuneit J, Lauener R, Pekkanen J, Pfefferle P, Riedler J, Roponen M, Weber J, von Mutius E, Braun-Fahrländer C, Vaarala O, PASTURE Study Group (Hirvonen MR, Hyvärinen A, Karvonen AM, Remes S, Roponen M, Tiittanen P, Dalphin ML, Kaulek V, Büchele G, Depner M, Ege M, Kabesch M, Pfefferle P, Renz H, Schaub B, Doekes G, Frei R). 2014. Pediatric allergy and immunology. 25: 329-337
Increased food diversity in the first year of life is inversely associated with allergic diseases
Roduit Caroline, Frei Remo, Depner Martin, Schaub Bianca, Loss Georg, Genuneit Jon, Pfefferle Petra, Hyvärinen Anne, Karvonen Anne M, Riedler Josef, Dalphin Jean-Charles, Pekkanen Juha, von Mutius Erika, Braun-Fahrländer Charlotte, Lauener Roger; PASTURE study group (Hirvonen Maija-Riitta, Remes Sami, Roponen Marjut, Tiittanen Petri, Dalphin Marie-Laure, Kaulek Vincent, Buchele Gisela, Ege Markus, Kabesch Michael, Renz Harald, Doekes Gert). 2014. Journal of allergy and clinical immunology. 133: 1056-1064
The effect of assay type and sample matrix on detected cytokine concentrations in human blood serum and nasal lavage fluid
Huttunen Kati, Tiihonen Kati, Roponen Marjut, Heederik Dick, Zock Jan-Paul, Täubel Martin, Hyvärinen Anne, Hirvonen Maija-Riitta. 2014. Journal of pharmaceutical and biomedical analysis. 96: 151-155
Atopic sensitization in the first year of life
Depner M, Ege MJ, Genuneit J, Pekkanen J, Roponen M, Hirvonen MR, Dalphin JC, Kaulek V, Krauss-Etschmann S, Riedler J, Braun-Fahrländer C, Roduit C, Lauener R, Pfefferle PI, Weber J, von Mutius E; PASTURE Study Group.. 2013. Journal of allergy and clinical immunology. 131: 781-788
Determinants, reproducibility, and seasonal variation of ergosterol levels in house dust
Leppänen HK, Nevalainen A, Vepsäläinen A, Roponen M, Täubel M, Laine O, Rantakokko P, von Mutius E, Pekkanen J, Hyvärinen A. 2013. Indoor air. 24: 248-259
Effect of moisture-damage intervention on the immunotoxic potential and microbial content of airborne particles and on occupants' upper airway inflammatory responses
Roponen M, Meklin T, Rintala H, Hyvärinen A, Hirvonen MR. 2013. Indoor air. 23: 295-302
Farm exposure and time trends in early childhood may influence DNA methylation in genes related to asthma and allergy
Michel S, Busato F, Genuneit J, Pekkanen J, Dalphin JC, Riedler J, Mazaleyrat N, Weber J, Karvonen AM, Hirvonen MR, Braun-Fahrländer C, Lauener R, von Mutius E, Kabesch M, Tost J; PASTURE study group.. 2013. Allergy. 68: 355-364
Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood
Lluis A, Depner M, Gaugler B, Saas P, Liu L, Genuneit J, Pfefferle P, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Lauener R, Vuitton D, Dalphin J-C, Pekkanen J, von Mutius E, Schaub B and the PASTURE study group. 2013. Journal of allergy and clinical immunology. -: -
Inflammatory response and IgE sensitization at early age
Mustonen K, Orivuori L, Keski-Nisula L, Hyvärinen A, Pfefferle PI, Riedler J, Dalphin JC, Genuneit J, Lauener R, Roduit C, Braun-Fahrländer C, Weber J, Schaub B, von Mutius E, Pekkanen J, Vaarala O; PASTURE Study Group.. 2013. Pediatric allergy and immunology. 24: 395-401
Soluble immunoglobulin A in breast milk is inversely associated with atopic dermatitis at early age: The PASTURE cohort study
Orivuori L, Loss G, Roduit C, Dalphin JC, Depner M, Genuneit J, Lauener R, Pekkanen J, Pfefferle P, Riedler J, Roponen M, Weber J, von Mutius E, Braun-Fahrländer C, Vaarala O; ThePASTURE Study Group. 2013. Clinical and experimental allergy. Epub: x-x
Development of atopic dermatitis according to age of onset and association with early-life exposures
Roduit Caroline, Frei Remo, Loss Georg, Büchele Gisela, Weber Juliane, Depner Martin, Loeliger Susanne, Dalphin Marie-Laure, Roponen Marjut, Hyvärinen Anne, Riedler Josef, Dalphin Jean-Charles, Pekkanen Juha, von Mutius Erika, Braun-Fahrländer Charlotte, Lauener Roger, PASTURE study group. 2012. Journal of allergy and clinical immunology. 130: 130-136
Exposure to microbial agents in house dust and wheezing, atopic dermatitis and atopic sensitization in early childhood: a birth cohort study in rural areas
Karvonen AM, Hyvärinen A, Gehring U, Korppi M, Doekes G, Riedler J, Braun-Fahrländer C, Bitter S, Schmid S, Keski-Nisula L, Roponen M, Kaulek V, Dalphin J-C, Pfefferle PI, Renz H, Büchele G, von Mutius E, Pekkanen J, the PASTURE Study Group. 2012. Clinical and experimental allergy. 42: 1246-1256
Few associations between high-sensitivity C-reactive protein and environmental factors in 4.5-year-old children
Mustonen K, Keski-Nisula L, Vaarala O, Pfefferle PI, Renz H, Riedler J, Dalphin JC, Buechele G, Lauener R, Braun-Fahrländer C, von Mutius E, Pekkanen J, the PASTURE Study Group, 19 jäsentä; Remes S. 2012. Pediatric allergy and immunology. 23: 522-528
High Indoor Microbial Levels Are Associated with Reduced Th1 Cytokine Secretion Capacity in Infancy
Lappalainen Mikko Harri Juhani, Hyvärinen Anne, Hirvonen Maija-Riitta, Rintala Helena, Roivainen Jarkko, Renz Harald, Pfefferle Petra Ina, Nevalainen Aino, Roponen Marjut, Pekkanen Juha. 2012. International archives of allergy and immunology. 159: 194-203
Occurrence of moisture problems in schools in three countries from different climatic regions of Europe based on questionnaires and building inspections - the HITEA study.
Haverinen-Shaughnessy U, Borras-Santos A, Turunen M, Zock JP, Jacobs J, Krop EJ, Casas L, Shaughnessy R, Täubel M, Heederik D, Hyvärinen A, Pekkanen J, Nevalainen A; HITEA study group (Bloom E, Chen CM, Doekes G, Heinrich J, Hirvonen MR, Huttunen K, Jarvis D, Krska R, Leppänen H, Peitzsch M,, Rintala H, Roponen M, Sulyok M, Sunyer J,Tischer C, Torrens M, Tiittanen P, Valkonen M, Vepsäläinen A, Vishwanath V, Wouters I). 2012. Indoor air. 22: 457-466
Prenatal and early-life exposures alter expression of innate immunity genes: The PASTURE cohort study
Loss Georg, Bitter Sondhja, Wohlgensinger Johanna, Frei Remo, Roduit Caroline, Genuneit Jon, Pekkanen Juha, Roponen Marjut, Hirvonen Maija-Riitta, Dalphin Jean-Charles, Dalphin Marie-Laure, Riedler Josef, von Mutius Erika, Weber Juliane, Kabesch Michael, Michel Sven, Braun-Fahrländer Charlotte, Lauener Roger, PASTURE study group. 2012. Journal of allergy and clinical immunology. 130: 523-530
Analytical performance of a multiplexed, bead-based cytokine detection system in small volume samples
Bomert M, Köllisch G, Roponen M, Lauener R, Renz H, Pfefferle PI, Al-Fakhri N. 2011. Clinical chemistry and laboratory medicine. 49: 1691-1693
Determinants of stimulated peripheral blood cytokine production among farming women
Lampi J, Roponen M, Hyvärinen A, Hirvonen MR, Larsson L, Nevalainen A, Pekkanen J. 2011. International journal of hygiene and environmental health. 214: 205-209
Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis
Roduit C, Wohlgensinger J, Frei R, Bitter S, Bieli C, Loeliger S, Büchele G, Riedler J, Dalphin JC, Remes S, Roponen M, Pekkanen J, Kabesch M, Schaub B, von Mutius E, Braun-Fahrländer C, Lauener R; PASTURE Study Group.. 2011. Journal of allergy and clinical immunology. 127: 179-185
Cord blood cytokines are modulated by maternal farming activities and consumption of farm dairy products during pregnancy: The PASTURE Study
Pfefferle PI, Büchele G, Blümer N, Roponen M, Ege MJ, Krauss-Etschmann S, Genuneit J, Hyvärinen A, Hirvonen MR, Lauener R, Pekkanen J, Riedler J, Dalphin JC, Brunekreef B, Braun-Fahrländer C, von Mutius E, Renz H & PASTURE Study Group. 2010. Journal of allergy and clinical immunology. 125: 108-115
Exposure to dogs is associated with a decreased tumour necrosis factor-&#945 -producing capacity in early life
Lappalainen MHJ, Huttunen K, Roponen M, Remes S, Hirvonen M-R & Pekkanen J. 2010. Clinical and experimental allergy. 40: 1498-1506
Maternal vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood
Rochat MK, Ege MJ, Plabst D, Steinle J, Bitter S, Braun-Fahrländer C, Dalphin J-C, Riedler J, Roponen M, Hirvonen M-R, Büchele G, Renz H, Lauener R, Krauss-Etschmann S, Von Mutius E &the PASTURE Study group. 2010. Clinical and experimental allergy. 40: 786-794
Production of interleukin-5, -10 and interferon-g in cord blood is strongly associated with the season of birth
Keski-Nisula L, Lappalainen MHJ, Mustonen K, Hirvonen M-R, Pfefferle PI, Renz H, Pekkanen J & Roponen M. 2010. Clinical and experimental allergy. 40: 1658-1668
Toll-like receptor 7 function is reduced in adolescents with asthma
Roponen M, Yerkovich ST, Hollams E, Sly PD, Holt PG & Upham JW. 2010. European respiratory journal. 35: 64-71

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Marjut Roponen

Research groups

Keywords

An integrated molecular risk score early in life for subsequent childhood asthma risk

Immune modulation by rural exposures and allergy protection

Impact of rising CO2 and temperature on grass phenology, physiology, and pollen release patterns in northern latitudes

Sources of PM2.5 exposure misclassification in three Finnish register-based study populations and the impact on attenuation of health effect estimates

Toxicological evaluation and concentration of airborne PM0.1 in high air pollution period in Guangzhou, China

Cattle farm dust alters cytokine levels in human airway construct model

Common Pollen Modulate Immune Responses against Viral-Like Challenges in Airway Coculture Model

Continuous rather than solely early farm exposure protect from hay fever development

Development of an Integrated Exposure Pathway Model for Health Impact Assessment of Traffic Ultrafine Particles (H2020 Ultrhas-Project)

Sources, chemical components, and toxicological responses of size segregated urban air PM samples in high air pollution season in Guangzhou, China

Suomalaisten pienhiukkasaltistuksen kehitys 1979-2021

Concentration, chemical composition and toxicological responses of the ultrafine fraction of urban air particles in PM1

Fine and ultrafine airborne PM influence inflammation response of young adults and toxicological responses in vitro

Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers

Pollen, respiratory viruses, and climate change: Synergistic effects on human health

Poultry exposure and environmental protection against asthma in rural children

Raskaudenaikainen altistuminen ilmansaasteille

Rural environment reduces allergic inflammation by modulating the gut microbiota

Systematic design of cell membrane coating to improve tumor targeting of nanoparticles

Winter and spring variation in sources, chemical components and toxicological responses of urban air particulate matter samples in Guangzhou, China

Associations of Particulate Matter Sizes and Chemical Constituents with Blood Lipids: A Panel Study in Guangzhou, China

Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles

Early age exposure to moisture and mould is related to FeNO at the age of 6 years

Mitogen-activated protein kinase signaling in childhood asthma development and environment-mediated protection

Short-Term Effects of Particle Size and Constituents on Blood Pressure in Healthy Young Adults in Guangzhou, China

Short-Term Effects of Particle Sizes and Constituents on Blood Biomarkers among Healthy Young Adults in Guangzhou, China

Toxicological and microbiological characterization of cow stable dust

Association Between Residential Greenness, Cardiometabolic Disorders, and Cardiovascular Disease Among Adults in China

Cryopreservation Affected the Levels of Immune Responses of PBMCs and Antigen-Presenting Cells

Greenness surrounding schools is associated with lower risk of asthma in schoolchildren.

Is PM 1 similar to PM 2.5? A new insight into the association of PM 1 and PM 2.5 with children's lung function

Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma

Modification of caesarean section on the associations between air pollution and childhood asthma in seven Chinese cities

Thermal dose as a universal tool to evaluate nanoparticle-induced photothermal therapy

Urban air PM modifies differently immune defense responses against bacterial and viral infections in vitro

Ambient Airborne Particulates of Diameter less than or equal to 1 micrometre, a Leading Contributor to the Association Between Ambient Airborne Particulates of Diameter less than or equal to 2.5 micrometres and Children's Blood Pressure

Association between antibiotic treatment during pregnancy & infancy and the development of allergic diseases

Association of Breastfeeding and Air Pollution Exposure With Lung Function in Chinese Children

Benefits of influenza vaccination on the associations between ambient air pollution and allergic respiratory diseases in children and adolescents: New insights from the Seven Northeastern Cities study in China

Farm-like indoor microbiota in non-farm homes protects children from asthma development

Greenness around schools associated with lower risk of hypertension among children: Findings from the Seven Northeastern Cities Study in China

Maatalomainen kodin mikrobisto voi suojata astmalta kaupungissakin

Parents know it best: Prediction of asthma and lung function by parental perception of early wheezing episodes

Prenatal exposure to perfluoroalkyl substances is associated with lower hand, foot and mouth disease viruses antibody response in infancy: Findings from the Guangzhou Birth Cohort Study

TNF-α-induced protein 3 is a key player in childhood asthma development and environment-mediated protection

A panel study of airborne particulate matter concentration and impaired cardiopulmonary function in young adults by two different exposure measurement

Early age exposure to moisture damage and systemic inflammation at the age of 6 years

High levels of Butyrate and Propionate in early life are associated with protection against atopy

Integrating farm and air pollution studies in search for immunoregulatory mechanisms operating in protective and high-risk environments

Is smaller worse? New insights about associations of PM1 and respiratory health in children and adolescents

Protective effects of breastfeeding on respiratory symptoms in infants with 17q21 asthma risk variants

Asthmatic farm children show increased CD3+CD8low T-cells compared to non-asthmatic farm children

Exposure to nonmicrobial N-glycolylneuraminic acid protects farmers' children against airway inflammation and colitis

Functional phenotypes determined by fluctuation-based clustering of lung function measurements in healthy and asthmatic cohort participants

Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children

Latent class analysis reveals clinically relevant atopy phenotypes in two birth cohorts

Phenotypes of atopic dermatitis depending on the timing of onset and progression in childhood

The lack of natural processes of delivery and neonatal intensive care treatment lead to impaired cytokine responses later in life

A switch in regulatory T cells through farm-exposure during immune maturation in childhood

Associations of Early Life Exposures and Environmental Factors With Asthma Among Children in Rural and Urban Areas of Guangdong, China

Enhanced T helper 1 and 2 cytokine responses at birth associate with lower risk of middle ear infections in infancy

IL-33 polymorphisms are associated with increased risk of hay fever and reduced regulatory T cells in a birth cohort

Maatila-altistuminen muokkaa lasten immuunivastetta sääteleviä mekanismeja

The Early Development of Wheeze: Environmental Determinants and Genetic Susceptibility at 17q21

Circulating dendritic cells, farm exposure and asthma at early age

Exposure to a farm environment is associated with Th1 and regulatory cytokines at age 4.5 years

Farm exposures are associated with lower percentage of circulating myeloid dendritic cell subtype 2 at age 6

High level of fecal calprotectin at age 2 months as a marker of intestinal inflammation predicts atopic dermatitis and asthma by age 6

Moisture damage in home associates with systemic inflammation in children

Clinical and Epidemiologic Phenotypes of Childhood Asthma

Consumption of unprocessed cow's milk protects infants from common respiratory infections

Determinants, reproducibility, and seasonal variation of bacterial cell wall components and viable counts in house dust

Immunoglobulin A and immunoglobulin G antibodies against ß-lactoglobulin and gliadin at age 1 associate with immunoglobulin E sensitization at age 6

Increased food diversity in the first year of life is inversely associated with allergic diseases

The effect of assay type and sample matrix on detected cytokine concentrations in human blood serum and nasal lavage fluid

Atopic sensitization in the first year of life