Merja Heinäniemi
Deputy Head of Unit
Professor
Institute of Biomedicine, School of Medicine, Faculty of Health Sciences
merja.heinaniemi@uef.fi | +358 40 355 3842
Research groups
Publications
20/66 items-
Comparison of high-throughput single-cell RNA-seq methods for ex vivo drug screening
Gezelius, Henrik; Enblad, Anna Pia; Lundmark, Anders; Åberg, Martin; Blom, Kristin; Rudfeldt, Jakob; Raine, Amanda; Harila, Arja; Rendo, Verónica; Heinäniemi, Merja; Andersson, Claes; Nordlund, Jessica. 2024. NAR genomics and bioinformatics. 6: . lqae001 -
A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies
Härkönen, Jouni; Pölönen, Petri; Deen, Ashik Jawahar; Selvarajan, Ilakya; Teppo, Hanna-Riikka; Dimova, Elitsa Y.; Kietzmann, Thomas; Ahtiainen, Maarit; Väyrynen, Juha P.; Väyrynen, Sara A.; Elomaa, Hanna; Tynkkynen, Niko; Eklund, Tiia; Kuopio, Teijo; Talvitie, Eva-Maria; Taimen, Pekka; Kallajoki, Markku; Kaikkonen, Minna U.; Heinäniemi, Merja; Levonen, Anna-Liisa. 2023. Redox biology. 61: -
Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia
Kuusanmäki, Heikki; Dufva, Olli; Vähä-Koskela, Markus; Leppä, Aino-Maija; Huuhtanen, Jani; Vänttinen, Ida Maria; Nygren, Petra Johanna; Klievink, Jay; Bouhlal, Jonas Otto Vilhelm; Pölönen, Petri; Zhang, Qi; Adnan Awad, Shady; Mancebo-Pérez, Cristina; Saad, Joseph; Miettinen, Juho J.; Javarappa, Komal Kumar; Aakko, Sofia; Ruokoranta, Tanja; Eldfors, Samuli; Heinäniemi, Merja; Theilgaard-Mönch, Kim; Wartiovaara-Kautto, Ulla; Keränen, Mikko A I; Porkka, Kimmo; Konopleva, Marina; Wennerberg, Krister. 2023. Blood. 141: 1610-1625 -
Generation of a Zebrafish Knock-In Model Recapitulating Childhood ETV6::RUNX1-Positive B-Cell Precursor Acute Lymphoblastic Leukemia
Zapilko, Veronika; Moisio, Sanni; Parikka, Mataleena; Heinäniemi, Merja; Lohi, Olli. 2023. Cancers. 15: -
Genomic Determinants of Therapy Response in ETV6::RUNX1 Leukemia
Oksa, Laura; Moisio, Sanni; Maqbool, Khurram; Foroughi-Asl, Hassan; Kramer, Roger; Nikkilä, Atte; Vepsäläinen, Kaisa; Duque-Afonso, Jesus; Hauer, Julia; Nordlund, Jessica; Wirta, Valtteri; Lohi, Olli; Heinäniemi, Merja. 2023. Blood -
In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution
Fischer, Anja; Lersch, Robert; de Andrade Krätzig, Niklas; Strong, Alexander; Friedrich, Mathias J.; Weber, Julia; Engleitner, Thomas; Öllinger, Rupert; Yen, Hsi-Yu; Kohlhofer, Ursula; Gonzalez-Menendez, Irene; Sailer, David; Kogan, Liz; Lahnalampi, Mari; Laukkanen, Saara; Kaltenbacher, Thorsten; Klement, Christine; Rezaei, Majdaddin; Ammon, Tim; Montero, Juan J.; Schneider, Günter; Mayerle, Julia; Heikenwälder, Mathias; Schmidt-Supprian, Marc; Quintanilla-Martinez, Leticia; Steiger, Katja; Liu,. 2023. Cell genomics. 3: -
Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia
Krali, Olga; Marincevic-Zuniga, Yanara; Arvidsson, Gustav; Enblad, Anna Pia; Lundmark, Anders; Sayyab, Shumaila; Zachariadis, Vasilios; Heinäniemi, Merja; Suhonen, Janne; Oksa, Laura; Vepsäläinen, Kaisa; Öfverholm, Ingegerd; Barbany, Gisela; Nordgren, Ann; Lilljebjörn, Henrik; Fioretos, Thoas; Madsen, Hans O; Marquart, Hanne Vibeke; Flaegstad, Trond; Forestier, Erik; Jónsson, Ólafur G; Kanerva, Jukka; Lohi, Olli; Norén-Nyström, Ulrika; Schmiegelow, Kjeld; Harila, Arja; Heyman, Mats; Lönnerholm, . 2023. npj precision oncology. 7: . 131 -
Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers
Dufva, Olli; Gandolfi, Sara; Huuhtanen, Jani; Dashevsky, Olga; Duàn, Hanna; Saeed, Khalid; Klievink, Jay; Nygren, Petra; Bouhlal, Jonas; Lahtela, Jenni; Näätänen, Anna; Ghimire, Bishwa R.; Hannunen, Tiina; Ellonen, Pekka; Lähteenmäki, Hanna; Rumm, Pauliina; Theodoropoulos, Jason; Laajala, Essi; Härkönen, Jouni; Pölönen, Petri; Heinäniemi, Merja; Hollmén, Maija; Yamano, Shizuka; Shirasaki, Ryosuke; Barbie, David A.; Roth, Jennifer A.; Romee, Rizwan; Sheffer, Michal; Lähdesmäki, Harri; Lee, Dean A. 2023. Immunity. 56: 2816-2835.e13 -
Combination therapies to inhibit LCK tyrosine kinase and mTOR signaling in T-cell Acute Lymphoblastic Leukemia
Laukkanen, Saara; Bacquelaine Veloso, Alexandra; Yan, Chuan; Oksa, Laura; Alpert, Eric J.; Do, Daniel; Hyvärinen, Noora; McCarthy, Karin; Adhikari, Abhinav; Yang, Qiqi; Iyer, Sowmya; Garcia, Sara P.; Pello, Annukka; Ruokoranta, Tanja; Moisio, Sanni; Adhikari, Sadiksha; Yoder, Jeffrey A.; Gallagher, Kayleigh Mary; Whelton, Lauren; Allen, James R.; Jin, Alexander Hai; Loontiens, Siebe; Heinäniemi, Merja; Kelliher, Michelle A; Heckman, Caroline A.; Lohi, Olli; Langenau, David M. 2022. Blood. 140: 1891–1906 -
Recurrent Germline Variant in RAD21 Predisposes Children to Lymphoblastic Leukemia or Lymphoma
Schedel, Anne; Friedrich, Ulrike Anne; Morcos, Mina N. F.; Wagener, Rabea; Mehtonen, Juha; Watrin, Titus; Saitta, Claudia; Brozou, Triantafyllia; Michler, Pia; Walter, Carolin; Försti, Asta; Baksi, Arka; Menzel, Maria; Horak, Peter; Paramasivam, Nagarajan; Fazio, Grazia; Autry, Robert J; Fröhling, Stefan; Suttorp, Meinolf; Gertzen, Christoph; Gohlke, Holger; Bhatia, Sanil; Wadt, Karin; Schmiegelow, Kjeld; Dugas, Martin; Richter, Daniela; Glimm, Hanno; Heinäniemi, Merja; Jessberger, Rolf; Cazzani. 2022. International journal of molecular sciences. 23: