Merja Heinäniemi
Professor
Institute of Biomedicine, School of Medicine, Faculty of Health Sciences
merja.heinaniemi@uef.fi | +358 40 355 3842
Research groups
Publications
15 items-
A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies
Härkönen, Jouni; Pölönen, Petri; Deen, Ashik Jawahar; Selvarajan, Ilakya; Teppo, Hanna-Riikka; Dimova, Elitsa Y.; Kietzmann, Thomas; Ahtiainen, Maarit; Väyrynen, Juha P.; Väyrynen, Sara A.; Elomaa, Hanna; Tynkkynen, Niko; Eklund, Tiia; Kuopio, Teijo; Talvitie, Eva-Maria; Taimen, Pekka; Kallajoki, Markku; Kaikkonen, Minna U.; Heinäniemi, Merja; Levonen, Anna-Liisa. 2023. Redox biology. 61: -
Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia
Kuusanmäki, Heikki; Dufva, Olli; Vähä-Koskela, Markus; Leppä, Aino-Maija; Huuhtanen, Jani; Vänttinen, Ida Maria; Nygren, Petra Johanna; Klievink, Jay; Bouhlal, Jonas Otto Vilhelm; Pölönen, Petri; Zhang, Qi; Adnan Awad, Shady; Mancebo-Pérez, Cristina; Saad, Joseph; Miettinen, Juho J.; Javarappa, Komal Kumar; Aakko, Sofia; Ruokoranta, Tanja; Eldfors, Samuli; Heinäniemi, Merja; Theilgaard-Mönch, Kim; Wartiovaara-Kautto, Ulla; Keränen, Mikko A I; Porkka, Kimmo; Konopleva, Marina; Wennerberg, Krister. 2023. Blood. 141: 1610-1625 -
In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution
Fischer, Anja; Lersch, Robert; de Andrade Krätzig, Niklas; Strong, Alexander; Friedrich, Mathias J.; Weber, Julia; Engleitner, Thomas; Öllinger, Rupert; Yen, Hsi-Yu; Kohlhofer, Ursula; Gonzalez-Menendez, Irene; Sailer, David; Kogan, Liz; Lahnalampi, Mari; Laukkanen, Saara; Kaltenbacher, Thorsten; Klement, Christine; Rezaei, Majdaddin; Ammon, Tim; Montero, Juan J.; Schneider, Günter; Mayerle, Julia; Heikenwälder, Mathias; Schmidt-Supprian, Marc; Quintanilla-Martinez, Leticia; Steiger, Katja; Liu,. 2023. Cell genomics. 3: -
Combination therapies to inhibit LCK tyrosine kinase and mTOR signaling in T-cell Acute Lymphoblastic Leukemia
Laukkanen, Saara; Bacquelaine Veloso, Alexandra; Yan, Chuan; Oksa, Laura; Alpert, Eric J.; Do, Daniel; Hyvärinen, Noora; McCarthy, Karin; Adhikari, Abhinav; Yang, Qiqi; Iyer, Sowmya; Garcia, Sara P.; Pello, Annukka; Ruokoranta, Tanja; Moisio, Sanni; Adhikari, Sadiksha; Yoder, Jeffrey A.; Gallagher, Kayleigh Mary; Whelton, Lauren; Allen, James R.; Jin, Alexander Hai; Loontiens, Siebe; Heinäniemi, Merja; Kelliher, Michelle A; Heckman, Caroline A.; Lohi, Olli; Langenau, David M. 2022. Blood. 140: 1891–1906 -
Recurrent Germline Variant in RAD21 Predisposes Children to Lymphoblastic Leukemia or Lymphoma
Schedel, Anne; Friedrich, Ulrike Anne; Morcos, Mina N. F.; Wagener, Rabea; Mehtonen, Juha; Watrin, Titus; Saitta, Claudia; Brozou, Triantafyllia; Michler, Pia; Walter, Carolin; Försti, Asta; Baksi, Arka; Menzel, Maria; Horak, Peter; Paramasivam, Nagarajan; Fazio, Grazia; Autry, Robert J; Fröhling, Stefan; Suttorp, Meinolf; Gertzen, Christoph; Gohlke, Holger; Bhatia, Sanil; Wadt, Karin; Schmiegelow, Kjeld; Dugas, Martin; Richter, Daniela; Glimm, Hanno; Heinäniemi, Merja; Jessberger, Rolf; Cazzani. 2022. International journal of molecular sciences. 23: -
Genome-wide analysis of primary microRNA expression using H3K36me3 ChIP-seq data
Turunen, Tanja; Hernández de Sande, Ana; Pölönen, Petri; Heinäniemi, Merja. 2021. Computational and Structural Biotechnology Journal. 19: 1944-1955 -
Immunogenomic Landscape of Hematological Malignancies
Dufva, Olli; Pölönen, Petri; Brück, Oscar; Keränen, Mikko AI; Klievink, Jay; Mehtonen, Juha; Huuhtanen, Jani; Kumar, Ashwini; Malani, Disha; Siitonen, Sanna; Kankainen, Matti; Ghimire, Bishwa; Lahtela, Jenni; Mattila, Pirkko; Vähä-Koskela, Markus; Wennerberg, Krister; Granberg, Kirsi; Leivonen, Suvi-Katri; Meriranta, Leo; Heckman, Caroline; et al. [incl. Heinäniemi, Merja]. 2020. Cancer cell. 38: 380-399.e13 -
Signalling input from divergent pathways subverts B cell transformation
Chan, Lai N; Murakami, Mark A; Robinson, Mark E; Caeser, Rebecca; Sadras, Teresa; Lee, Jaewoong; Cosgun, Kadriye Nehir; Kume, Kohei; Khairnar, Vishal; Xiao, Gang; Ahmed, Mohamed A; Aghania, Eamon; Deb, Gauri; Hurtz, Christian; Shojaee, Seyedmehdi; Hong, Chao; Pölönen, Petri; Nix, Matthew A; Chen, Zhengshan; Chen, Chun Wei; Chen, Jianjun. 2020. Nature. 583: 845-851 -
Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities
Mehtonen, Juha; Teppo, Susanna; Lahnalampi, Mari; Kokko, Aleksi; Kaukonen, Riina; Oksa, Laura; Bouvy-Liivrand, Maria; Malyukova, Alena; Mäkinen, Artturi; Laukkanen, Saara; Mäkinen, Petri I; Rounioja, Samuli; Ruusuvuori, Pekka; Sangfelt, Olle; Lund, Riikka; Lönnberg, Tapio; Lohi, Olli; Heinäniemi, Merja. 2020. Genome medicine. 12: Article number: 99 -
Hemap: An interactive online resource for characterizing molecular phenotypes across hematologic malignancies
Pölönen, P; Mehtonen, J; Lin, J; Liuksiala, T; Häyrynen, S; Teppo, S; Mäkinen, A; Kumar, A; Malani, D; Pohjolainen, V; Porkka, K; Heckman, CA; May, P; Hautamäki, V; Granberg, KJ; Lohi, O; Nykter, M; Heinäniemi, M. 2019. Cancer research. 79: 2466-2479