NOORA PUHAKKA

Contact info

RESEARCH GROUPS - UEF

• 
  Epilepsy Research

Publications

• Das Gupta, Shalini; Ciszek, Robert; Heiskanen, Mette; Lapinlampi, Niina; Kukkonen, Janne; Leinonen, Ville; Puhakka, Noora; Pitkänen, Asla. 2021. Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury International journal of molecular sciences 22 4: 1563. 2021
• Pitkänen, Asla; Paananen, Tomi; Kyyriäinen, Jenni; Das Gupta, Shalini; Heiskanen, Mette; Vuokila, Niina; Bañuelos-Cabrera, Ivette; Lapinlampi, Niina; Kajevu, Natallie; Andrade, Pedro; Ciszek, Robert; Lara-Valderrábano, Leonardo; Ekolle Ndode-Ekane, Xavier; Puhakka, Noora. 2021. Biomarkers for posttraumatic epilepsy Epilepsy and behavior in press, corrected proof: 1-22. 2021
• Das Gupta, Shalini; Ndode-Ekane, Xavier Ekolle; Puhakka, Noora; Pitkänen, Asla. 2020. Droplet digital polymerase chain reaction-based quantification of circulating microRNAs using small RNA concentration normalization Scientific reports 10: 9012. 2020
• Korotkov, Anatoly; Puhakka, Noora; Gupta, Shalini Das; Vuokila, Niina; Broekaart, Diede W M; Anink, Jasper J; Heiskanen, Mette; Karttunen, Jenni; van Scheppingen, Jackelien; Huitinga, Inge; Mills, James D; van Vliet, Erwin A; Pitkänen, Asla; Aronica, Eleonora. 2020. Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation Brain pathology 30 5: 897-912. 2020
• Lapinlampi, N; Andrade, P; Paananen, T; Hämäläinen, E; Ekolle Ndode-Ekane, X; Puhakka, N; Pitkänen, A. 2020. Postinjury weight rather than cognitive or behavioral impairment predicts development of posttraumatic epilepsy after lateral fluid-percussion injury in rats Epilepsia 61 9: 2035-2052. 2020
• Vuokila, Niina; Aronica, Eleonora; Korotkov, Anatoly; van Vliet, Erwin Alexander; Nuzhat, Salma; Puhakka, Noora; Pitkänen, Asla. 2020. Chronic Regulation of miR-124-3p in the Perilesional Cortex After Experimental and Human TBI International journal of molecular sciences 21 7: 2418. 2020
• Vuokila, Niina; Gupta, Shalini Das; Huusko, Riina; Tohka, Jussi; Puhakka, Noora; Pitkänen, Asla. 2020. Elevated acute plasma miR-124-3p level relates to evolution of larger cortical lesion area after traumatic brain injury Neuroscience 433: 21-35. 2020
• Immonen, R; Smith, G; Brady, RD; Wright, D; Johnston, L; Harris, NG; Manninen, E; Salo, R; Branch, C; Duncan, D; Cabeen, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Shultz, SR; Andrade, P; Puhakka, N; Staba, RJ; O'Brien, TJ; et al.. 2019. Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis Epilepsy research 150: 46-57. 2019
• Santana-Gomez, C; Andrade, P; Hudson, MR; Paananen, T; Ciszek, R; Smith, G; Ali, I; Rundle, BK; Ndode-Ekane, XE; Casillas-Espinosa, PM; Immonen, R; Puhakka, N; Jones, N; Brady, RD; Perucca, P; Shultz, SR; Pitkänen, A; O'Brien, TJ; Staba, R. 2019. Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis Epilepsy research 156: 106110. 2019
• Pitkänen, Asla; Ekolle, Ndode-Ekane Xavier; Lapinlampi, Niina; Puhakka, Noora. 2019. Epilepsy biomarkers - Toward etiology and pathology specificity Neurobiology of disease 123: 42-58. 2019
• Ndode-Ekane, XE; Santana-Gomez, C; Casillas-Espinosa, PM; Ali, I; Brady, RD; Smith, G; Andrade, P; Immonen, R; Puhakka, N; Hudson, MR; Braine, EL; Shultz, SR; Staba, RJ; O'Brien, TJ; Pitkänen, A. 2019. Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis Epilepsy research 151: 7-16. 2019
• Anwer, Mehwish; Lara-Valderrabano, Leonardo; Karttunen, Jenni; Ndode-Ekane, Xavier Ekolle; Puhakka, Noora; Pitkänen, Asla. 2019. Acute downregulation of novel hypothalamic protein sushi repeat-containing protein X-Linked 2 (SRPX2) after experimental traumatic brain injury Journal of neurotrauma 2020; 37 7: 924-938. 2019
• Das Gupta, S; Lipponen, A; Paldanius, KMA; Puhakka, N; Pitkänen, A. 2019. Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury Scientific reports 9: 20208. 2019
• Casillas-Espinosa, PM; Andrade, P; Santana-Gomez, C; Paananen, T; Smith, G; Ali, I; Ciszek, R; Ndode-Ekane, XE; Brady, RD; Tohka, J; Hudson, MR; Perucca, P; Braine, EL; Immonen, R; Puhakka, N; Shultz, SR; Jones, NC; Staba, RJ; Pitkänen, A; O'Brien, TJ. 2019. Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis Epilepsy research 156: 106131. 2019
• Anwer, M; Immonen, R; Hayward, NMEA; Ndode-Ekane, XE; Puhakka, N; Gröhn, O; Pitkänen, A. 2019. Lateral fluid-percussion injury leads to pituitary atrophy in rats Scientific reports 9 1: 11819. 2019
• Anwer, M; Bolkvadze, T; Puhakka, N; Ndode-Ekane, XE; Pitkänen, A. 2019. Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2) Neuroscience 415: 184-200. 2019
• Vuokila, Niina; Lukasiuk, Katarzyna; Bot, Anna Maria; van Vliet, Erwin A; Aronica, Eleonora; Pitkänen, Asla; Puhakka Niina. 2018. miR-124-3p is a chronic regulator of gene expression after brain injury Cellular and molecular life sciences 75 24: 4557-4581. 2018
• Lipponen, Anssi; El-Osta, Assam; Kaspi, Antony; Ziemann, Mark; Khurana, Ishant; Harikrishnan, K N; Navarro-Ferrandis, Vicente; Puhakka, Noora; Paananen, Jussi; Pitkänen, Asla. 2018. Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury. Acta neuropathologica communications 6: 17. 2018
• Karttunen, Jenni; Heiskanen, Mette; Navarro-Ferrandis, Vicente; Das Gupta, Shalini; Lipponen, Anssi; Puhakka, Noora; Rilla, Kirsi; Koistinen, Arto; Pitkänen, Asla. 2018. Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs Journal of Extracellular Vesicles 2019; 8 1: 1555410. 2018
• Kamnaksh, A; Puhakka, N; Ali, I; Smith, G; Aniceto, R; McCullough, J; Das Gupta, S; Ndode-Ekane, XE; Brady, R; Casillas-Espinosa, P; Hudson, M; Santana-Gomez, C; Immonen, R; Abreu, PA; Jones, N; Shultz, S; Staba, RJ; O'Brien, TJ; Agoston, D; Pitkänen, A. 2018. Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis EPILEPSY RESEARCH 2019; 149: 92-101. 2018
• Anwer, M; Bolkvadze, T; Ndode-Ekane, XE; Puhakka, N; Rauramaa, T; Leinonen, V; van Vliet, EA; Swaab, DF; Haapasalo, A; Leskelä, S; Bister, N; Malm, T; Carlson, S; Aronica, E; Pitkänen, A. 2018. Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein JOURNAL OF COMPARATIVE NEUROLOGY 526 11: 1806-1819. 2018
• Ciszek, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Smith, G; Puhakka, N; Lapinlampi, N; Andrade, P; Kamnaksh, A; Immonen, R; Paananen, T; Hudson, MR; Brady, RD; Shultz, SR; O'Brien, TJ; Staba, RJ; Tohka, J; Pitkänen, A. 2018. Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis EPILEPSY RESEARCH 2019; 150: 17-26. 2018
• Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks-Kayal AR, Engel J Jr, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, Pearl PL, Pitkänen A, Puhakka N, Rogawski MA, Schmidt D et al.. 2017. Commonalities in epileptogenic processes from different acute brain insults: Do they translate?. EPILEPSIA (NY) 2018; 59 1: 37-66. 2017
• Puhakka Noora, Bot Anna Maria, Vuokila Niina, Debski Konrad Jozef, Lukasiuk Katarzyna, Pitkänen Asla. 2017. Chronically dysregulated NOTCH1 interactome in the dentate gyrus after traumatic brain injury. PLOS ONE 12 3: e0172521. 2017
• van Vliet Erwin A, Puhakka Noora, Mills James D, Srivastava Prashant K, Johnson Michael R, Roncon Paolo, Das Gupta Shalini, Karttunen Jenni, Simonato Michele, Lukasiuk Katarzyna, Gorter Jan A, Aronica Eleonora, Pitkänen Asla. 2017. Standardization procedure for plasma biomarker analysis in rat models of epileptogenesis: Focus on circulating microRNAs. EPILEPSIA (NY) 58 12: 2013-2024. 2017
• Bolkvadze T, Puhakka N, Pitkänen A. 2016. Epileptogenesis after traumatic brain injury in Plaur-deficient mice. EPILEPSY & BEHAVIOR 60 July 2016: 187-196. 2016
• Debski KJ, Pitkanen A, Puhakka N, Bot AM, Khurana I, Harikrishnan KN, Ziemann M, Kaspi A, El-Osta A, Lukasiuk K, Kobow K. 2016. Etiology matters - Genomic DNA methylation patterns in three rat models of acquired epilepsy. Scientific Reports 6: 25668. 2016
• Lipponen Anssi, Paananen Jussi, Puhakka Noora, Pitkänen Asla. 2016. Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44, and S100a4 as Treatment Targets. Scientific Reports 6: 31570. 2016
• Bolkvadze Tamuna, Rantala Jukka, Puhakka Noora, Andrade Petro, Pitkänen Asla. 2015. Epileptogenesis after traumatic brain injury in Plau-deficient mice. EPILEPSY & BEHAVIOR 51: 19-27. 2015
• Pitkänen A, Huusko N, Ndode-Ekane XE, Kyyriäinen J, Lipponen A, Lipsanen A, Sierra A, Bolkvadze T. 2014. Gender issues in antiepileptogenic treatments. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 2014 Jun 6 ePub ahead of print: pii: S0969-9961(14)00163-6. 2014
• Pitkänen Asla, Kemppainen Samuli, Ndode-Ekane Xavier Ekolle, Huusko Noora, Huttunen Joanna K, Gröhn Olli, Immonen Riikka, Sierra Alejandra, Bolkvadze Tamuna. 2014. Posttraumatic epilepsy - Disease or comorbidity?. EPILEPSY & BEHAVIOR 2014 Feb 11. [Epub ahead of print]: --. 2014
• Drexel M, Puhakka N, Kirchmair E, Hörtnagl H, Pitkänen A, Sperk G. 2014. Expression of GABA receptor subunits in the hippocampus and thalamus after experimental traumatic brain injury. NEUROPHARMACOLOGY 2014 Sep 16: pii: S0028-3908(14)00306-2. 2014
• Huusko Noora. 2014. GABAergic network alterations in rat models of acquired epilepsy. Publications of the University of Eastern Finland. Dissertations in Health Sciences 223. 2014
• Huusko N, Pitkänen A. 2014. Parvalbumin immunoreactivity and expression of GABAA receptor subunits in the thalamus after experimental TBI. NEUROSCIENCE 2014 May 16;267: 30-45.. 2014
• Huusko N, Römer C, Ndode-Ekane XE, Lukasiuk K, Pitkänen A. 2013. Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsy. Brain structure & function 2015; 220 1: 153-191. 2013
• The Seventh Annual Post-Graduate Symposium of the doctoral program in molecular medicine Winter School 2013. Abstracts. Belt H, Huusko N, Kaminska D, Munoz Ruiz M, Paasonen J, Pellinen R. 2013 2013
• The Sixth Annual Post-Graduate Symposium of the Doctoral Program in Molecular Medicine: Winter School 2012. Abstracts. Natunen T, Belt H, Huusko N, Jääskeläinen A, Sutinen P, Pellinen R. 2012 2012
• Pavlov I,Huusko N,Drexel M,Kirchmair E,Sperk G,Pitkänen A,Walker MC. 2011. Progressive loss of phasic, but not tonic, GABAA receptor-mediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats NEUROSCIENCE 194: 208-219. 2011
• Lahtinen L, Huusko N, Myöhänen H, Lehtivarjo AK, Pellinen R, Turunen MP, Ylä-Herttuala S, Pirinen E, Pitkänen A. 2009. Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus. NEUROSCIENCE 163: 316-328. 2009