Noora Puhakka

Discovery and Validation of Circulating microRNAs as Biomarkers for Epileptogenesis after Experimental Traumatic Brain Injury–The EPITARGET Cohort

Heiskanen, Mette; Das Gupta, Shalini; Mills, James D; van Vliet, Erwin A; Manninen, Eppu; Ciszek, Robert; Andrade, Pedro; Puhakka, Noora; Aronica, Eleonora; Pitkänen, Asla. 2023. International journal of molecular sciences. 24:

Gene Expression Profile as a Predictor of Seizure Liability

Lipponen, Anssi; Kajevu, Natallie; Natunen, Teemu; Ciszek, Robert; Puhakka, Noora; Hiltunen, Mikko; Pitkänen, Asla. 2023. International journal of molecular sciences. 24:

Image data harmonization tools for the analysis of post-traumatic epilepsy development in preclinical multisite MRI studies

Bhagavatula, Sweta; Cabeen, Ryan; Harris, Neil G.; Gröhn, Olli; Wright, David K.; Garner, Rachael; Bennett, Alexis; Alba, Celina; Martinez, Aubrey; Ndode-Ekane, Xavier Ekolle; Andrade, Pedro; Paananen, Tomi; Ciszek, Robert; Immonen, Riikka; Manninen, Eppu; Puhakka, Noora; Tohka, Jussi; Heiskanen, Mette; Ali, Idrish; Shultz, Sandy R.; Casillas-Espinosa, Pablo M.; Yamakawa, Glenn R.; Jones, Nigel C.; Hudson, Matthew R.; Silva, Juliana C.; Braine, Emma L.; Brady, Rhys D.; Santana-Gomez, Cesar E.; S. 2023. Epilepsy research. 195:

Proteomics of Deep Cervical Lymph Nodes After Experimental Traumatic Brain Injury

Puhakka, Noora; Das Gupta, Shalini; Leskinen, Sara; Heiskanen, Mette; Nattinen, Janika; Aapola, Ulla; Uusitalo, Hannu; Pitkanen, Asla. 2023. Neurotrauma reports. 4: 359-366

Treatment of Status Epilepticus after Traumatic Brain Injury Using an Antiseizure Drug Combined with a Tissue Recovery Enhancer Revealed by Systems Biology

Kajevu, Natallie; Lipponen, Anssi; Andrade, Pedro; Bañuelos, Ivette; Puhakka, Noora; Hämäläinen, Elina; Natunen, Teemu; Hiltunen, Mikko; Pitkänen, Asla. 2023. International journal of molecular sciences. 24: . 14049

Plasma Neurofilament Light Chain (NF-L) Is a Prognostic Biomarker for Cortical Damage Evolution but Not for Cognitive Impairment or Epileptogenesis Following Experimental TBI

Heiskanen, Mette; Jääskeläinen, Olli; Manninen, Eppu; Das Gupta, Shalini; Andrade, Pedro; Ciszek, Robert; Gröhn, Olli; Herukka, Sanna-Kaisa; Puhakka, Noora; Pitkänen, Asla. 2022. International journal of molecular sciences. 23:

Transfer RNA-Derived Fragments and isomiRs Are Novel Components of Chronic TBI-Induced Neuropathology

Puhakka, Noora; Das Gupta, Shalini; Vuokila, Niina; Pitkänen, Asla. 2022. Biomedicines. 10:

Biomarkers for posttraumatic epilepsy

Pitkänen, Asla; Paananen, Tomi; Kyyriäinen, Jenni; Das Gupta, Shalini; Heiskanen, Mette; Vuokila, Niina; Bañuelos-Cabrera, Ivette; Lapinlampi, Niina; Kajevu, Natallie; Andrade, Pedro; Ciszek, Robert; Lara-Valderrábano, Leonardo; Ekolle Ndode-Ekane, Xavier; Puhakka, Noora. 2021. Epilepsy and behavior. 121: 107080

Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury

Das Gupta, Shalini; Ciszek, Robert; Heiskanen, Mette; Lapinlampi, Niina; Kukkonen, Janne; Leinonen, Ville; Puhakka, Noora; Pitkänen, Asla. 2021. International journal of molecular sciences. 22: 1563

Regulation of parvalbumin interactome in the perilesional cortex after experimental traumatic brain injury

Hiltunen, Johanna; Ndode-Ekane, Xavier Ekolle; Lipponen, Anssi; Drexel, Meinrad; Sperk, Günther; Puhakka, Noora; Pitkänen, Asla. 2021. Neuroscience. 475: 52-72

Chronic Regulation of miR-124-3p in the Perilesional Cortex After Experimental and Human TBI

Vuokila, Niina; Aronica, Eleonora; Korotkov, Anatoly; van Vliet, Erwin Alexander; Nuzhat, Salma; Puhakka, Noora; Pitkänen, Asla. 2020. International journal of molecular sciences. 21: 2418

Droplet digital polymerase chain reaction-based quantification of circulating microRNAs using small RNA concentration normalization

Das Gupta, Shalini; Ndode-Ekane, Xavier Ekolle; Puhakka, Noora; Pitkänen, Asla. 2020. Scientific reports. 10: 9012

Elevated acute plasma miR-124-3p level relates to evolution of larger cortical lesion area after traumatic brain injury

Vuokila, Niina; Gupta, Shalini Das; Huusko, Riina; Tohka, Jussi; Puhakka, Noora; Pitkänen, Asla. 2020. Neuroscience. 433: 21-35

Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation

Korotkov, Anatoly; Puhakka, Noora; Gupta, Shalini Das; Vuokila, Niina; Broekaart, Diede W M; Anink, Jasper J; Heiskanen, Mette; Karttunen, Jenni; van Scheppingen, Jackelien; Huitinga, Inge; Mills, James D; van Vliet, Erwin A; Pitkänen, Asla; Aronica, Eleonora. 2020. Brain pathology. 30: 897-912

Postinjury weight rather than cognitive or behavioral impairment predicts development of posttraumatic epilepsy after lateral fluid-percussion injury in rats

Lapinlampi, N; Andrade, P; Paananen, T; Hämäläinen, E; Ekolle Ndode-Ekane, X; Puhakka, N; Pitkänen, A. 2020. Epilepsia. 61: 2035-2052

Acute downregulation of novel hypothalamic protein sushi repeat-containing protein X-Linked 2 (SRPX2) after experimental traumatic brain injury

Anwer, Mehwish; Lara-Valderrabano, Leonardo; Karttunen, Jenni; Ndode-Ekane, Xavier Ekolle; Puhakka, Noora; Pitkänen, Asla. 2019. Journal of neurotrauma. 2020; 37: 924-938

Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury

Das Gupta, S; Lipponen, A; Paldanius, KMA; Puhakka, N; Pitkänen, A. 2019. Scientific reports. 9: 20208

Epilepsy biomarkers - Toward etiology and pathology specificity

Pitkänen, Asla; Ekolle, Ndode-Ekane Xavier; Lapinlampi, Niina; Puhakka, Noora. 2019. Neurobiology of disease. 123: 42-58

Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2)

Anwer, M; Bolkvadze, T; Puhakka, N; Ndode-Ekane, XE; Pitkänen, A. 2019. Neuroscience. 415: 184-200

Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis

Ndode-Ekane, XE; Santana-Gomez, C; Casillas-Espinosa, PM; Ali, I; Brady, RD; Smith, G; Andrade, P; Immonen, R; Puhakka, N; Hudson, MR; Braine, EL; Shultz, SR; Staba, RJ; O'Brien, TJ; Pitkänen, A. 2019. Epilepsy research. 151: 7-16

Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis

Santana-Gomez, C; Andrade, P; Hudson, MR; Paananen, T; Ciszek, R; Smith, G; Ali, I; Rundle, BK; Ndode-Ekane, XE; Casillas-Espinosa, PM; Immonen, R; Puhakka, N; Jones, N; Brady, RD; Perucca, P; Shultz, SR; Pitkänen, A; O'Brien, TJ; Staba, R. 2019. Epilepsy research. 156: 106110

Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis

Immonen, R; Smith, G; Brady, RD; Wright, D; Johnston, L; Harris, NG; Manninen, E; Salo, R; Branch, C; Duncan, D; Cabeen, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Shultz, SR; Andrade, P; Puhakka, N; Staba, RJ; O'Brien, TJ; et al.. 2019. Epilepsy research. 150: 46-57

Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis

Casillas-Espinosa, PM; Andrade, P; Santana-Gomez, C; Paananen, T; Smith, G; Ali, I; Ciszek, R; Ndode-Ekane, XE; Brady, RD; Tohka, J; Hudson, MR; Perucca, P; Braine, EL; Immonen, R; Puhakka, N; Shultz, SR; Jones, NC; Staba, RJ; Pitkänen, A; O'Brien, TJ. 2019. Epilepsy research. 156: 106131

Lateral fluid-percussion injury leads to pituitary atrophy in rats

Anwer, M; Immonen, R; Hayward, NMEA; Ndode-Ekane, XE; Puhakka, N; Gröhn, O; Pitkänen, A. 2019. Scientific reports. 9: 11819

Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis

Kamnaksh, A; Puhakka, N; Ali, I; Smith, G; Aniceto, R; McCullough, J; Das Gupta, S; Ndode-Ekane, XE; Brady, R; Casillas-Espinosa, P; Hudson, M; Santana-Gomez, C; Immonen, R; Abreu, PA; Jones, N; Shultz, S; Staba, RJ; O'Brien, TJ; Agoston, D; Pitkänen, A. 2018. Epilepsy research. 2019; 149: 92-101

Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis

Ciszek, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Smith, G; Puhakka, N; Lapinlampi, N; Andrade, P; Kamnaksh, A; Immonen, R; Paananen, T; Hudson, MR; Brady, RD; Shultz, SR; O'Brien, TJ; Staba, RJ; Tohka, J; Pitkänen, A. 2018. Epilepsy research. 2019; 150: 17-26

Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs

Karttunen, Jenni; Heiskanen, Mette; Navarro-Ferrandis, Vicente; Das Gupta, Shalini; Lipponen, Anssi; Puhakka, Noora; Rilla, Kirsi; Koistinen, Arto; Pitkänen, Asla. 2018. Journal of extracellular vesicles. 2019; 8: 1555410

Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein

Anwer, M; Bolkvadze, T; Ndode-Ekane, XE; Puhakka, N; Rauramaa, T; Leinonen, V; van Vliet, EA; Swaab, DF; Haapasalo, A; Leskelä, S; Bister, N; Malm, T; Carlson, S; Aronica, E; Pitkänen, A. 2018. Journal of comparative neurology. 526: 1806-1819

Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury

Lipponen, Anssi; El-Osta, Assam; Kaspi, Antony; Ziemann, Mark; Khurana, Ishant; Harikrishnan, K N; Navarro-Ferrandis, Vicente; Puhakka, Noora; Paananen, Jussi; Pitkänen, Asla. 2018. Acta neuropathologica communications. 6: 17

miR-124-3p is a chronic regulator of gene expression after brain injury

Vuokila, Niina; Lukasiuk, Katarzyna; Bot, Anna Maria; van Vliet, Erwin A; Aronica, Eleonora; Pitkänen, Asla; Puhakka Niina. 2018. Cellular and molecular life sciences. 75: 4557-4581

Chronically dysregulated NOTCH1 interactome in the dentate gyrus after traumatic brain injury

Puhakka Noora, Bot Anna Maria, Vuokila Niina, Debski Konrad Jozef, Lukasiuk Katarzyna, Pitkänen Asla. 2017. PLoS ONE. 12: e0172521

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks-Kayal AR, Engel J Jr, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, Pearl PL, Pitkänen A, Puhakka N, Rogawski MA, Schmidt D et al.. 2017. Epilepsia. 2018; 59: 37-66

Standardization procedure for plasma biomarker analysis in rat models of epileptogenesis: Focus on circulating microRNAs

van Vliet Erwin A, Puhakka Noora, Mills James D, Srivastava Prashant K, Johnson Michael R, Roncon Paolo, Das Gupta Shalini, Karttunen Jenni, Simonato Michele, Lukasiuk Katarzyna, Gorter Jan A, Aronica Eleonora, Pitkänen Asla. 2017. Epilepsia. 58: 2013-2024

Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44, and S100a4 as Treatment Targets

Lipponen Anssi, Paananen Jussi, Puhakka Noora, Pitkänen Asla. 2016. Scientific reports. 6: 31570

Epileptogenesis after traumatic brain injury in Plaur-deficient mice

Bolkvadze T, Puhakka N, Pitkänen A. 2016. Epilepsy and behavior. 60: 187-196

Etiology matters - Genomic DNA methylation patterns in three rat models of acquired epilepsy

Debski KJ, Pitkanen A, Puhakka N, Bot AM, Khurana I, Harikrishnan KN, Ziemann M, Kaspi A, El-Osta A, Lukasiuk K, Kobow K. 2016. Scientific reports. 6: 25668

Epileptogenesis after traumatic brain injury in Plau-deficient mice

Bolkvadze Tamuna, Rantala Jukka, Puhakka Noora, Andrade Petro, Pitkänen Asla. 2015. Epilepsy and behavior. 51: 19-27

Expression of GABA receptor subunits in the hippocampus and thalamus after experimental traumatic brain injury

Drexel M, Puhakka N, Kirchmair E, Hörtnagl H, Pitkänen A, Sperk G. 2014. Neuropharmacology. 2014 Sep 16: pii: S0028-3908(14)00306-2

GABAergic network alterations in rat models of acquired epilepsy

Huusko Noora. 2014. Publications of the University of Eastern Finland. Dissertations in Health Sciences

Gender issues in antiepileptogenic treatments

Pitkänen A, Huusko N, Ndode-Ekane XE, Kyyriäinen J, Lipponen A, Lipsanen A, Sierra A, Bolkvadze T. 2014. Neurobiology of disease. 2014 Jun 6 ePub ahead of print: pii: S0969-9961(14)00163-6

Parvalbumin immunoreactivity and expression of GABAA receptor subunits in the thalamus after experimental TBI

Huusko N, Pitkänen A. 2014. Neuroscience. : 30-45.

Posttraumatic epilepsy - Disease or comorbidity?

Pitkänen Asla, Kemppainen Samuli, Ndode-Ekane Xavier Ekolle, Huusko Noora, Huttunen Joanna K, Gröhn Olli, Immonen Riikka, Sierra Alejandra, Bolkvadze Tamuna. 2014. Epilepsy and behavior. 2014 Feb 11.: --

Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsy

Huusko N, Römer C, Ndode-Ekane XE, Lukasiuk K, Pitkänen A. 2013. Brain structure and function. 2015; 220: 153-191

The Seventh Annual Post-Graduate Symposium of the doctoral program in molecular medicine Winter School 2013. Abstracts

Belt H, Huusko N, Kaminska D, Munoz Ruiz M, Paasonen J, Pellinen R. 2013. Publications of the University of Eastern Finland. Reports and studies in health sciences. . Itä-Suomen yliopisto

The Sixth Annual Post-Graduate Symposium of the Doctoral Program in Molecular Medicine: Winter School 2012. Abstracts

Natunen T, Belt H, Huusko N, Jääskeläinen A, Sutinen P, Pellinen R. 2012. Publications of the University of Eastern Finland. Reports and studies in health sciences. . Eastern Finland University Library/ Sales of Publications

Progressive loss of phasic, but not tonic, GABAA receptor-mediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats

Pavlov I,Huusko N,Drexel M,Kirchmair E,Sperk G,Pitkänen A,Walker MC. 2011. Neuroscience. 194: 208-219

Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus

Lahtinen L, Huusko N, Myöhänen H, Lehtivarjo AK, Pellinen R, Turunen MP, Ylä-Herttuala S, Pirinen E, Pitkänen A. 2009. Neuroscience. 163: 316-328

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Discovery and Validation of Circulating microRNAs as Biomarkers for Epileptogenesis after Experimental Traumatic Brain Injury–The EPITARGET Cohort

Gene Expression Profile as a Predictor of Seizure Liability

Image data harmonization tools for the analysis of post-traumatic epilepsy development in preclinical multisite MRI studies

Proteomics of Deep Cervical Lymph Nodes After Experimental Traumatic Brain Injury

Treatment of Status Epilepticus after Traumatic Brain Injury Using an Antiseizure Drug Combined with a Tissue Recovery Enhancer Revealed by Systems Biology

Plasma Neurofilament Light Chain (NF-L) Is a Prognostic Biomarker for Cortical Damage Evolution but Not for Cognitive Impairment or Epileptogenesis Following Experimental TBI

Transfer RNA-Derived Fragments and isomiRs Are Novel Components of Chronic TBI-Induced Neuropathology

Biomarkers for posttraumatic epilepsy

Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury

Regulation of parvalbumin interactome in the perilesional cortex after experimental traumatic brain injury

Chronic Regulation of miR-124-3p in the Perilesional Cortex After Experimental and Human TBI

Droplet digital polymerase chain reaction-based quantification of circulating microRNAs using small RNA concentration normalization

Elevated acute plasma miR-124-3p level relates to evolution of larger cortical lesion area after traumatic brain injury

Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation

Postinjury weight rather than cognitive or behavioral impairment predicts development of posttraumatic epilepsy after lateral fluid-percussion injury in rats

Acute downregulation of novel hypothalamic protein sushi repeat-containing protein X-Linked 2 (SRPX2) after experimental traumatic brain injury

Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury

Epilepsy biomarkers - Toward etiology and pathology specificity

Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2)

Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis

Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis

Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis

Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis

Lateral fluid-percussion injury leads to pituitary atrophy in rats

Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis

Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis

Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs

Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein

Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury

miR-124-3p is a chronic regulator of gene expression after brain injury

Chronically dysregulated NOTCH1 interactome in the dentate gyrus after traumatic brain injury

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

Standardization procedure for plasma biomarker analysis in rat models of epileptogenesis: Focus on circulating microRNAs

Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44, and S100a4 as Treatment Targets

Epileptogenesis after traumatic brain injury in Plaur-deficient mice

Etiology matters - Genomic DNA methylation patterns in three rat models of acquired epilepsy

Epileptogenesis after traumatic brain injury in Plau-deficient mice

Expression of GABA receptor subunits in the hippocampus and thalamus after experimental traumatic brain injury

GABAergic network alterations in rat models of acquired epilepsy

Gender issues in antiepileptogenic treatments

Parvalbumin immunoreactivity and expression of GABAA receptor subunits in the thalamus after experimental TBI

Posttraumatic epilepsy - Disease or comorbidity?

Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsy

The Seventh Annual Post-Graduate Symposium of the doctoral program in molecular medicine Winter School 2013. Abstracts

The Sixth Annual Post-Graduate Symposium of the Doctoral Program in Molecular Medicine: Winter School 2012. Abstracts

Progressive loss of phasic, but not tonic, GABAA receptor-mediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats

Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus