Olli Gröhn
Professor
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
olli.grohn@uef.fi | +358 50 359 0963
0503590963
050 3590963
050 359 0963
+358 50 359 0963
+35850 359 0963
050 3590 963
+358 50 3590 963
+35850 3590 963
+358 50 3590963
+35850 3590963
+358503590963
050 3590963
050 359 0963
+358 50 359 0963
+35850 359 0963
050 3590 963
+358 50 3590 963
+35850 3590 963
+358 50 3590963
+35850 3590963
+358503590963
Publications
207 items-
A consensus protocol for functional connectivity analysis in the rat brain
Grandjean, Joanes; Desrosiers-Gregoire, Gabriel; Anckaerts, Cynthia; Angeles-Valdez, Diego; Ayad, Fadi; Barrière, David A.; Blockx, Ines; Bortel, Aleksandra; Broadwater, Margaret; Cardoso, Beatriz M.; Célestine, Marina; Chavez-Negrete, Jorge E.; Choi, Sangcheon; Christiaen, Emma; Clavijo, Perrin; Colon-Perez, Luis; Cramer, Samuel; Daniele, Tolomeo; Dempsey, Elaine; Diao, Yujian; Doelemeyer, Arno; Dopfel, David; Dvořáková, Lenka; Falfán-Melgoza, Claudia; Fernandes, Francisca F.; Fowler, Caitlin F. 2023. Nature neuroscience. 26: 673-681 -
Axon fiber orientation as the source of T1 relaxation anisotropy in white matter: A study on corpus callosum in vivo and ex vivo
Kauppinen, Risto A; Thothard, Jeromy; Leskinen, Henri PP; Pisharady, Pramod K; Manninen, Eppu; Kettunen, Mikko; Lenglet, Christophe; Gröhn, Olli HJ; Garwood, Michael; Nissi, Mikko J. 2023. Magnetic resonance in medicine. 90: 708-721 -
Diffusion MRI approaches for investigating microstructural complexity in a rat model of traumatic brain injury
Chary, Karthik; Manninen, Eppu; Claessens, Jade; Ramirez-Manzanares, Alonso; Gröhn, Olli; Sierra, Alejandra. 2023. Scientific reports. 13: . 2219 -
Orientation selective stimulation with tetrahedral electrodes of the rat infralimbic cortex to indirectly target the amygdala
Gureviciene, Irina; Laakso, Hanne; Narvaez, Omar; Paasonen, Ekaterina; Lehto, Lauri; Gurevicius, Kestutis; Mangia, Silvia; Michaeli, Shalom; Gröhn, Olli; Sierra, Alejandra; Tanila, Heikki. 2023. Frontiers in neuroscience. 17: . 1147547 -
A companion to the preclinical common data elements and case report forms for in vivo rodent neuroimaging: A report of the TASK3-WG3 Neuroimaging Working Group of the ILAE/AES Joint Translational Task Force
van Vliet, Erwin A.; Immonen, Riikka; Prager, Ofer; Friedman, Alon; Bankstahl, Jens P.; Wright, David K.; O'Brien, Terence J.; Potschka, Heidrun; Gröhn, Olli; Harris, Neil G.. 2022. Epilepsia open. [First published: 13 August 2022]: 1-47 -
Acute Hippocampal Damage as a Prognostic Biomarker for Cognitive Decline but Not for Epileptogenesis after Experimental Traumatic Brain Injury
Manninen, Eppu; Chary, Karthik; De Feo, Riccardo; Hämäläinen, Elina; Andrade, Pedro; Paananen, Tomi; Sierra, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkänen, Asla. 2022. Biomedicines. 10: -
Chronic hypometabolism in striatum and hippocampal network after traumatic brain injury and their relation with memory impairment – [18F]-FDG-PET and MRI 4 months after fluid percussion injury in rat
Yasmin, Amna; Jokivarsi, Kimmo; Poutiainen, Pekka; Pitkänen, Asla; Gröhn, Olli; Immonen, Riikka. 2022. Brain research. 1788: -
Convolutional Neural Networks Enable Robust Automatic Segmentation of the Rat Hippocampus in MRI After Traumatic Brain Injury
De Feo, Riccardo; Hämäläinen, Elina; Manninen, Eppu; Immonen, Riikka; Valverde, Juan Miguel; Ndode-Ekane, Xavier Ekolle; Gröhn, Olli; Pitkänen, Asla; Tohka, Jussi. 2022. Frontiers in neurology. 13: . 820267 -
Event‐recurring multiband SWIFT functional MRI with 200‐ms temporal resolution during deep brain stimulation and isoflurane‐induced burst suppression in rat
Paasonen, Ekaterina; Paasonen, Jaakko; Lehto, Lauri J; Pirttimäki, Tiina; Laakso, Hanne; Wu, Lin; Ma, Jun; Idiyatullin, Djaudat; Tanila, Heikki; Mangia, Silvia; Michaeli, Shalom; Gröhn, Olli. 2022. Magnetic resonance in medicine. 87: 2872-2884 -
Hippocampal position and orientation as prognostic biomarkers for posttraumatic epileptogenesis: An experimental study in a rat lateral fluid percussion model
De Feo, Riccardo; Manninen, Eppu; Chary, Karthik; Hämäläinen, Elina; Immonen, Riikka; Andrade, Pedro; Ndode‐Ekane, Xavier Ekolle; Gröhn, Olli; Pitkänen, Asla; Tohka, Jussi. 2022. Epilepsia. 63: 1849-1861 -
Histopathological modeling of status epilepticus-induced brain damage based on in vivo diffusion tensor imaging in rats
San Martín Molina, Isabel; Salo, Raimo A.; Gröhn, Olli; Tohka, Jussi; Sierra, Alejandra. 2022. Frontiers in neuroscience. 16: . 944432 -
MRI-Guided Electrode Implantation for Chronic Intracerebral Recordings in a Rat Model of Post−Traumatic Epilepsy—Challenges and Gains
Ndode-Ekane, Xavier Ekolle; Immonen, Riikka; Hämäläinen, Elina; Manninen, Eppu; Andrade, Pedro; Ciszek, Robert; Paananen, Tomi; Gröhn, Olli; Pitkänen, Asla. 2022. Biomedicines. 10: -
Orientation selective DBS of entorhinal cortex and medial septal nucleus modulates activity of rat brain areas involved in memory and cognition
Wu, Lin; Canna, Antonietta; Narvaez, Omar; Ma, Jun; Sang, Sheng; Lehto, Lauri J.; Sierra, Alejandra; Tanila, Heikki; Zhang, Yuan; Gröhn, Olli; Low, Walter C.; Filip, Pavel; Mangia, Silvia; Michaeli, Shalom. 2022. Scientific reports. 12: . 8565 -
Plasma Neurofilament Light Chain (NF-L) Is a Prognostic Biomarker for Cortical Damage Evolution but Not for Cognitive Impairment or Epileptogenesis Following Experimental TBI
Heiskanen, Mette; Jääskeläinen, Olli; Manninen, Eppu; Das Gupta, Shalini; Andrade, Pedro; Ciszek, Robert; Gröhn, Olli; Herukka, Sanna-Kaisa; Puhakka, Noora; Pitkänen, Asla. 2022. International journal of molecular sciences. 23: -
Relaxation anisotropy of quantitative MRI parameters in biological tissues
Hänninen, Nina Elina; Liimatainen, Timo; Hanni, Matti; Gröhn, Olli; Nieminen, Miika Tapio; Nissi, Mikko Johannes. 2022. Scientific reports. 12: . 12155 -
Spatial signatures of anesthesia-induced burst-suppression differ between primates and rodents
Sirmpilatze, Nikoloz; Mylius, Judith; Ortiz-Rios, Michael; Baudewig, Jürgen; Paasonen, Jaakko; Golkowski, Daniel; Ranft, Andreas; Ilg, Rüdiger; Gröhn, Olli; Boretius, Susann. 2022. eLife. 11: . e74813 -
State Estimation of Time-Varying MRI with Radial Golden Angle Sampling
Wettenhovi, Ville-Veikko; Kolehmainen, Ville; Kettunen, Mikko; Gröhn, Olli; Vauhkonen, Marko. 2022. Journal of mathematical imaging and vision. 64: 825-844 -
Whole-brain studies of spontaneous behavior in head-fixed rats enabled by zero echo time MB-SWIFT fMRI
Paasonen, Jaakko; Stenroos, Petteri; Laakso, Hanne; Pirttimäki, Tiina; Paasonen, Ekaterina; Salo, Raimo A.; Tanila, Heikki; Idiyatullin, Djaudat; Garwood, Michael; Michaeli, Shalom; Mangia, Silvia; Gröhn, Olli. 2022. Neuroimage. 250: -
Acute thalamic damage as a prognostic biomarker for post-traumatic epileptogenesis
Manninen, Eppu; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkänen, Asla. 2021. Epilepsia. 62: 1852-1864 -
Automated joint skull-stripping and segmentation with Multi-Task U-Net in large mouse brain MRI databases
De Feo, Riccardo; Shatillo, Artem; Sierra, Alejandra; Valverde, Juan Miguel; Gröhn, Olli; Giove, Federico; Tohka, Jussi. 2021. Neuroimage. 229: 117734 -
Brain fMRI during orientation selective epidural spinal cord stimulation
Canna, Antonietta; Lehto, Lauri J; Wu, Lin; Sang, Sheng; Laakso, Hanne; Ma, Jun; Filip, Pavel; Zhang, Yuan; Gröhn, Olli; Esposito, Fabrizio; Chen, Clark C; Lavrov, Igor; Michaeli, Shalom; Mangia, Silvia. 2021. Scientific reports. 11: 5504 -
Data-Driven Regularization Parameter Selection in Dynamic MRI
Hanhela, Matti; Gröhn, Olli; Kettunen, Mikko; Niinimäki, Kati; Vauhkonen, Marko; Kolehmainen, Ville. 2021. Journal of imaging. 7: 38 -
Infantile status epilepticus disrupts myelin development
Bencurova, Petra; Laakso, Hanne; Salo, Raimo A; Paasonen, Ekaterina; Manninen, Eppu; Paasonen, Jaakko; Michaeli, Shalom; Mangia, Silvia; Bares, Martin; Brazdil, Milan; Kubova, Hana; Gröhn, Olli. 2021. Neurobiology of disease. 2022; 162: 105566 -
Isoflurane affects brain functional connectivity in rats 1 month after exposure
Stenroos, Petteri; Pirttimäki, Tiina; Paasonen, Jaakko; Paasonen, Ekaterina; Salo, Raimo A; Koivisto, Hennariikka; Natunen, Teemu; Mäkinen, Petra; Kuulasmaa, Teemu; Hiltunen, Mikko; Tanila, Heikki; Gröhn, Olli. 2021. Neuroimage. 234: 117987 -
Light sedation with short habituation time for large-scale functional magnetic resonance imaging studies in rats
Dvoráková, Lenka; Stenroos, Petteri; Paasonen, Ekaterina; Salo, Raimo A.; Paasonen, Jaakko; Gröhn, Olli. 2021. Nmr in biomedicine. 2022; 35: -
Metabolism of hyperpolarised [1-13C]pyruvate in awake and anaesthetised rat brains
Hyppönen, Viivi; Stenroos, Petteri; Nivajärvi, Riikka; Ardenkjaer-Larsen, Jan Henrik; Gröhn, Olli; Paasonen, Jaakko; Kettunen, Mikko I. 2021. Nmr in biomedicine. 2022; 35: e4635 -
Microstructural Tissue Changes in a Rat Model of Mild Traumatic Brain Injury
Chary Karthik, Narvaez Omar, Salo Raimo A, San Martín Molina Isabel, Tohka Jussi, Aggarwal Manisha, Gröhn Olli, Sierra Alejandra. 2021. Frontiers in neuroscience. 15: 746214 -
Post-injury ventricular enlargement associates with iron in choroid plexus but not with seizure susceptibility nor lesion atrophy - 6-month MRI follow-up after experimental traumatic brain injury
Yasmin, Amna; Pitkänen, Asla; Andrade, Pedro; Paananen, Tomi; Gröhn, Olli; Immonen, Riikka. 2021. Brain structure and function. 2022; 227: 145-158 -
RAFF-4, Magnetization Transfer and Diffusion Tensor MRI of Lysophosphatidylcholine Induced Demyelination and Remyelination in Rats
Holikova, Klara; Laakso, Hanne; Salo, Raimo; Shatillo, Artem; Nurmi, Antti; Bares, Martin; Vanicek, Jiri; Michaeli, Shalom; Mangia, Silvia; Sierra, Alejandra; Gröhn, Olli. 2021. Frontiers in neuroscience. 15: 625167 -
Ratiometric magnetic resonance imaging: Contrast agent design towards better specificity and quantification
Genicio, Nuria; Bañobre-López, Manuel; Gröhn, Olli; Gallo, Juan. 2021. Coordination chemistry reviews. 447: 214150 -
Relaxation Anisotropy in Biological Tissues
Hänninen N; Nissi MJ; Hanni M; Gröhn OHJ; Nieminen MT; Liimatainen T. 2021. -
Spinal cord fMRI with MB-SWIFT for assessing epidural spinal cord stimulation in rats
Laakso, Hanne; Lehto, Lauri J; Paasonen, Jaakko; Salo, Raimo; Canna, Antonietta; Lavrov, Igor; Michaeli, Shalom; Gröhn, Olli; Mangia, Silvia. 2021. Magnetic resonance in medicine. 86: 2137-2145 -
Steerable3D: An ImageJ plugin for neurovascular enhancement in 3-D segmentation
Miocchi, Paolo; Sierra, Alejandra; Maugeri, Laura; Stefanutti, Eleonora; Abdollahzadeh, Ali; Mangini, Fabio; Moraschi, Marta; Bukreeva, Inna; Massimi, Lorenzo; Brun, Francesco; Tohka, Jussi; Gröhn, Olli; Mittone, Alberto; Bravin, Alberto; Nicaise, Charles; Giove, Federico; Cedola, Alessia; Fratini, Michela. 2021. Physica medica. 81: 197-209 -
A Computational Diffusion MRI Framework for Biomarker Discovery in a Rodent Model of Post-Traumatic Epileptogenesis
Cabeen, Ryan P; Immonen, Riikka; Harris, Neil G; Gröhn, Olli; Smith, Gregory; Manninen, Eppu; Garner, Rachael; Duncan, Dominique; Pitkänen, Asla; Toga, Arthur W. Teoksessa: -(toim.) , 2020. 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI). s. 1013-1017. IEEE -
Assessment of the structural complexity of diffusion MRI voxels using 3D electron microscopy in the rat brain
Salo, Raimo A; Belevich, Ilya; Jokitalo, Eija; Gröhn, Olli; Sierra, Alejandra. 2020. Neuroimage. 225: 117529 -
Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1-13 C]pyruvate
Nivajärvi, R; Olsson, V; Hyppönen, V; Bowen, S; Leinonen, HM; Lesch, HP; Ardenkjaer-Larsen, JH; Gröhn, OHJ; Ylä-Herttuala, S; Kettunen, MI. 2020. Nmr in biomedicine. 33: e4250 -
Early increase in cortical T2 relaxation is a prognostic biomarker for the evolution of severe cortical damage, but not for epileptogenesis, after experimental traumatic brain injury
Manninen, Eppu Matias; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra Lopez, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkanen, Asla. 2020. Journal of neurotrauma. 37: 2580-2594 -
In vivo diffusion tensor imaging in acute and subacute phases of mild traumatic brain injury in rats
San Martín Molina, Isabel; Salo, Raimo A; Abdollahzadeh, Ali; Tohka, Jussi; Gröhn, Olli; Sierra, Alejandra. 2020. eNeuro. 7: ENEURO.0476-19.2020 -
Individual head models for estimating the TMS-induced electric field in rat brain
Koponen, Lari M; Stenroos, Matti; Nieminen, Jaakko O; Jokivarsi, Kimmo; Gröhn, Olli; Ilmoniemi, Risto J. 2020. Scientific reports. 10: 17397 -
Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury
van Vliet, Erwin A; Ndode-Ekane, Xavier Ekolle; Lehto, Lauri J; Gorter, Jan A; Andrade, Pedro; Aronica, Eleonora; Gröhn, Olli; Pitkänen, Asla. 2020. Neurobiology of disease. 145: 1-20 -
Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat
Paasonen, J; Laakso, H; Pirttimäki, T; Stenroos, P; Salo, RA; Zhurakovskaya, E; Lehto, LJ; Tanila, H; Garwood, M; Michaeli, S; Idiyatullin, D; Mangia, S; Gröhn, O. 2020. Neuroimage. 206: 116338 -
Multiscale Imaging Approach for Studying the Central Nervous System: Methodology and Perspective
Fratini, Michela; Abdollahzadeh, Ali; DiNuzzo, Mauro; Salo, Raimo; Maugeri, Laura; Cedola, Alessia; Giove, Federico; Gröhn, Olli; Tohka, Jussi; Sierra, Alejandra. 2020. Frontiers in neuroscience. 14: 72 -
Orientation selective deep brain stimulation of the subthalamic nucleus in rats
Lehto, Lauri; Canna, Antonietta; Wu, Lin; Sierra, Alejandra; Zhurakovskaya, E; Ma, Jun; Pearce, Clairice; Shaio, Maple; Filip, Pavel; Johnson, Matthew; Low, Walter; Gröhn, Olli; Tanila, Heikki; Mangia, Silvia; Michaeli, Shalom. 2020. Neuroimage. 213: 116750 -
RatLesNetv2: A Fully Convolutional Network for Rodent Brain Lesion Segmentation
Valverde, Juan Miguel; Shatillo, Artem; De Feo, Riccardo; Gröhn, Olli; Sierra, Alejandra; Tohka, Jussi. 2020. Frontiers in neuroscience. 14: 610239 -
Temporal Huber Regularization for DCE-MRI
Hanhela, Matti; Kettunen, Mikko; Gröhn, Olli; Vauhkonen, Marko; Kolehmainen, Ville. 2020. Journal of mathematical imaging and vision. 62: 1334-1346 -
Automatic Rodent Brain MRI Lesion Segmentation with Fully Convolutional Networks
Valverde, JM; Shatillo, A; De Feo, R; Gröhn, O; Sierra, A; Tohka, J. Teoksessa: Suk, HI; Liu, M; Yan, P; Lian, C(toim.) , 2019. Machine Learning in Medical Imaging. MLMI 2019. s. 195-202. Springer -
Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain
Knight, MJ; Damion, RA; McGarry, BL; Bosnell, R; Jokivarsi, KT; Gröhn, OHJ; Jezzard, P; Harston, GWJ; Carone, D; Kennedy, J; El-Tawil, S; Elliot, J; Muir, KW; Clatworthy, P; Kauppinen, RA. 2019. Biomedical spectroscopy and imaging. 8: 11-28 -
Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis
Immonen, R; Smith, G; Brady, RD; Wright, D; Johnston, L; Harris, NG; Manninen, E; Salo, R; Branch, C; Duncan, D; Cabeen, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Shultz, SR; Andrade, P; Puhakka, N; Staba, RJ; O'Brien, TJ; et al.. 2019. Epilepsy research. 150: 46-57 -
Impaired hippocampal-cortical coupling but preserved local synchrony during sleep in APP/PS1 mice modeling Alzheimer's disease
Zhurakovskaya, E; Ishchenko, I; Gureviciene, I; Aliev, R; Gröhn, O; Tanila, H. 2019. Scientific reports. 9: 5380 -
Lateral fluid-percussion injury leads to pituitary atrophy in rats
Anwer, M; Immonen, R; Hayward, NMEA; Ndode-Ekane, XE; Puhakka, N; Gröhn, O; Pitkänen, A. 2019. Scientific reports. 9: 11819 -
MRS Reveals Chronic Inflammation in T2w MRI-Negative Perilesional Cortex - A 6-Months Multimodal Imaging Follow-Up Study
Yasmin, Amna; Pitkänen, Asla; Jokivarsi, Kimmo; Poutiainen, Pekka; Gröhn, Olli; Immonen, Riikka. 2019. Frontiers in neuroscience. 13: 863 -
Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine?
Mikhailov, N; Leskinen, J; Fagerlund, I; Poguzhelskaya, E; Giniatullina, R; Gafurov, O; Malm, T; Karjalainen, T; Gröhn, O; Giniatullin, R. 2019. Neuropharmacology. 149: 113-123 -
Sleep-State Dependent Alterations in Brain Functional Connectivity under Urethane Anesthesia in a Rat Model of Early-Stage Parkinson's Disease
Zhurakovskaya, Ekaterina; Leikas, Juuso; Pirttimäki, Tiina; Casas Mon, Francesc; Gynther, Mikko; Aliev, Rubin; Rantamäki, Tomi; Tanila, Heikki; Forsberg, Markus M; Gröhn, Olli; Paasonen, Jaakko; Jalkanen, Aaro J. 2019. eNeuro. 6: 1-12 -
The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol
Vespa, PM; Shrestha, V; Abend, N; Agoston, D; Au, A; Bell, MJ; Bleck, TP; Blanco, MB; Claassen, J; Diaz-Arrastia, R; Duncan, D; Ellingson, B; Foreman, B; Gilmore, EJ; Hirsch, L; Hunn, M; Kamnaksh, A; McArthur, D; Morokoff, A; O'Brien, T; et al. (incl. Gröhn, Olli). 2019. Neurobiology of disease. 123: 110-114 -
Awake Rat Brain Functional Magnetic Resonance Imaging Using Standard Radio Frequency Coils and a 3D Printed Restraint Kit
Stenroos, Petteri; Paasonen, Jaakko; Salo, Raimo A; Jokivarsi, Kimmo; Shatillo, Artem; Tanila, Heikki; Gröhn, Olli. 2018. Frontiers in neuroscience. 12: 548 -
Clinical deep brain stimulation strategies for orientation-selective pathway activation
Slopsema, Julia P; Peña, Edgar; Patriat, Remi; Lehto, Lauri J; Gröhn, Olli; Mangia, Silvia; Harel, Noam; Michaeli, Shalom; Johnson, Matthew D. 2018. Journal of neural engineering. 15: 56029 -
Detection of Hyperexcitability by fMRI After Experimental Traumatic Brain Injury
Huttunen, JK; Airaksinen, AM; Barba, C; Colicchio, G; Niskanen, JP; Shatillo, A; Sierra Lopez, A; Ndode-Ekane, XE; Pitkanen, A; Gröhn, O. 2018. Journal of neurotrauma. 35: 2708-2717 -
Dynamic MRI reconstruction from undersampled data with an anatomical prescan
Rasch, Julian; Kolehmainen, Ville; Nivajärvi, Riikka; Kettunen, Mikko; Grohn, Olli; Burger, Martin; Brinkmann, Eva-Maria. 2018. Inverse problems. 34: 74001 -
Functional connectivity under six anesthesia protocols and the awake condition in rat brain
Paasonen, Jaakko; Stenroos, Petteri; Salo, Raimo A; Kiviniemi, Vesa; Gröhn Olli. 2018. Neuroimage. 172: 9-20 -
Imaging biomarkers of epileptogenecity after traumatic brain injury - Preclinical frontiers
Immonen, Riikka; Harris, Neil G; Wright, David; Johnston, Leigh; Manninen, Eppu; Smith, Gregory; Paydar, Afshin; Branch, Craig; Grohn Olli. 2018. Neurobiology of disease. 2019; 123: 75-85 -
Quantification of anisotropy and orientation in 3D electron microscopy and diffusion tensor imaging in injured rat brain
Salo, Raimo A; Belevich, Ilya; Manninen, Eppu; Jokitalo, Eija; Gröhn, Olli; Sierra, Alejandra. 2018. Neuroimage. 172: 404-414 -
Spontaneous BOLD waves - A novel hemodynamic activity in Sprague-Dawley rat brain detected by functional magnetic resonance imaging
Shatillo, A; Lipponen, A; Salo, RA; Tanila, H; Verkhratsky, A; Giniatullin, R; Gröhn, OH. 2018. Journal of cerebral blood flow and metabolism. 2019; 39: 1949-1960 -
State estimation in dynamic MRI
Wettenhovi, Ville-Veikko; Kolehmainen, Ville; Huttunen, Joanna; Kettunen, Mikko; Gröhn, Olli; Vauhkonen, Marko. Teoksessa: -(toim.) , 2018. 2018 IEEE Nuclear Science Symposium and Medical Imaging (NSS/MIC): Conference Proceedings. s. 1-6. IEEE -
Tuning Neuromodulation Effects by Orientation Selective Deep Brain Stimulation in the Rat Medial Frontal Cortex
Lehto, Lauri J; Filip, Pavel; Laakso, Hanne; Sierra, Alejandra; Slopsema, Julia P; Johnson, Matthew D; Eberly, Lynn E; Low, Walter C; Gröhn, Olli; Tanila, Heikki; Mangia, Silvia; Michael, Shalom. 2018. Frontiers in neuroscience. 12: 899 -
A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
McGarry BL, Jokivarsi KT, Knight MJ, Grohn OHJ, Kauppinen RA. 2017. Journal of visualized experiments. 127: 1-6 -
Conceptual Design of Flex-DBS, a Mechanically Reconfigurable Deep Brain Stimulation Probe
Johnson G, Lehto L, Mangia S, Gröhn O, Michaeli S, Kodandaramaiah S. Teoksessa: -(toim.) , 2017. Proceedings of the 2017 Design of Medical Devices Conference. s. V001T02A001. American Society of Mechanical Engineers -
Diffusion tensor MRI shows progressive changes in the hippocampus and dentate gyrus after status epilepticus in rat - histological validation with Fourier-based analysis
Salo RA, Miettinen T, Laitinen T, Gröhn O, Sierra A. 2017. Neuroimage. 152: 221-236 -
Dose-response effect of acute phencyclidine on functional connectivity and dopamine levels, and their association with schizophrenia-like symptom classes in rat
Paasonen J, Salo RA, Ihalainen J, Leikas JV, Savolainen K, Lehtonen M, Forsberg MM, Gröhn O. 2017. Neuropharmacology. 119: 15-25 -
In Vivo Imaging in Rodents
Gröhn O, Deleye S, Bertoglio D, Dedeurwaerdere S. Teoksessa: Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL(toim.) , 2017. Models of Seizures and Epilepsy (Second Edition). s. 197-215. Elsevier -
Lysophosphatidyl Choline Induced Demyelination in Rat Probed by Relaxation along a Fictitious Field in High Rank Rotating Frame
Lehto Lauri J, Albors Aloma A. Sierra Alejandra, Tolppanen Laura, Eberly Lynn E, Mangia Silvia, Nurmi Antti, Michaeli Shalom, Gröhn Olli. 2017. Frontiers in neuroscience. 11: 433 -
MB-SWIFT functional MRI during deep brain stimulation in rats
Lehto Lauri J, Idiyatullin Djaudat, Zhang Jinjin, Utecht Lynn, Adriany Gregor, Garwood Michael, Gröhn Olli, Michaeli Shalom, Mangia Silvia. 2017. Neuroimage. 159: 443-448 -
Magnetization transfer SWIFT MRI consistently detects histologically verified myelin loss in the thalamocortical pathway after a traumatic brain injury in rat
Lehto LJ, Sierra A, Gröhn O. 2017. Nmr in biomedicine. 30: e3678 -
Neuroimaging in animal models of epilepsy
Bertoglio Daniele, Verhaeghe Jeroen, Dedeurwaerdere Stefanie, Gröhn Olli. 2017. Neuroscience. 358: 277-299 -
Nuclei-specific deposits of iron and calcium in the rat thalamus after status epilepticus revealed with quantitative susceptibility mapping (QSM)
Aggarwal M, Li X, Gröhn O, Sierra A. 2017. Journal of magnetic resonance imaging. 2018; 47: 554-564 -
Orientation selective deep brain stimulation
Lehto Lauri J, Slopsema Julia P, Johnson Matthew D, Shatillo Artem, Teplitzky Benjamin A, Utecht Lynn, Adriany Gregor, Mangia Silvia, Sierra Alejandra, Low Walter C, Gröhn Olli, Michaeli Shalom. 2017. Journal of neural engineering. 14: 16016 -
Searching for epilepsy's crystal ball
Gröhn Olli, Sierra Alejandra. 2017. eLife. 6: e29853 -
State Estimation with Structural Priors in fMRI
Wettenhovi Ville-Veikko, Kolehmainen Ville, Huttunen Joanna, Kettunen Mikko, Gröhn Olli, Vauhkonen Marko. 2017. Journal of mathematical imaging and vision. 2018; 60: 174-188 -
Stroke onset time determination using MRI relaxation times without non-ischaemic reference in a rat stroke model
Norton Terence JT, Pereyra Marcelo, Knight Michael J, McGarry Bryony M, Jokivarsi Kimmo T, Grohn Olli HJ, Kauppinen Risto A. 2017. Biomedical spectroscopy and imaging. 6: 25-35 -
A spatiotemporal theory for MRI T2 relaxation time and apparent diffusion coefficient in the brain during acute ischaemia: application and validation in a rat acute stroke model
Knight MJ, Mcgarry BL, Rogers HJ, Jokivarsi KT, Gröhn OHJ, Kauppinen RA. 2016. Journal of cerebral blood flow and metabolism. 36: 1232-1243 -
Advances in the development of biomarkers for epilepsy
Pitkänen A, Löscher W, Vezzani A, Becker AJ, Simonato M, Lukasiuk K, Gröhn O, Bankstahl JP, Friedman A, Aronica E, Gorter JA, Ravizza T, Sisodiya SM, Kokaia M, Beck H. 2016. The Lancet Neurology. 15: 843-856 -
Common data elements and data management: Remedy to cure underpowered preclinical studies
Lapinlampi N, Melin E, Aronica E, Bankstahl JP, Becker A, Bernard C, Gorter JA, Gröhn O, Lipsanen A, Lukasiuk K, Löscher W, Paananen J, Ravizza T, Roncon P, Simonato M, Vezzani A, Kokaia M, Pitkänen A. 2016. Epilepsy research. 129: 87-90 -
Comparison of seven different anesthesia protocols for nicotine pharmacologic magnetic resonance imaging in rat
Paasonen Jaakko, Salo Raimo A, Shatillo Artem, Forsberg Markus M, Närväinen Johanna, Huttunen Joanna K, Gröhn Olli. 2016. European neuropsychopharmacology. 26: 518-531 -
Determining stroke onset time using quantitative MRI: High accuracy, sensitivity and specificity obtained from magnetic resonance relaxation times
McGarry BL, Rogers HJ, Knight MJ, Jokivarsi KT, Gröhn OHJ, Kauppinen RA. 2016. Cerebrovascular diseases extra. 6: 60-65 -
Effect of collagen cross-linking on quantitative MRI parameters of articular cartilage
Rautiainen J, Nieminen MT, Salo EN, Kokkonen HT, Mangia S, Michaeli S, Gröhn O, Jurvelin JS, Töyräs J, Nissi MJ. 2016. Osteoarthritis and cartilage. 24: 1656-1664 -
Global Functional Connectivity Differences between Sleep-Like States in Urethane Anesthetized Rats Measured by fMRI
Zhurakovskaya Ekaterina, Paasonen Jaakko, Shatillo Artem, Lipponen Arto, Salo Raimo, Aliev Raimo, Tanila Heikki, Gröhn Olli. 2016. PLoS ONE. 11: e0155343 -
Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents
Pirttimäki T, Salo RA, Shatillo A, Kettunen MI, Paasonen J, Sierra A, Jokivarsi K, Leinonen V, Andrade P, Quittek S, Pitkänen A, Gröhn O. 2016. Journal of neuroscience methods. 274: 154-163 -
Protective Effects and Magnetic Resonance Imaging Temperature Mapping of Systemic and Focal Hypothermia in Cerebral Ischemia
Vieites-Prado Alba, Iglesias-Rey Ramón, Fernández-Susavila Héctor, da Silva-Candal Andrés, Rodríguez-Castro Emilio, Gröhn Olli HJ, Wellmann Sven, Sobrino Tomás, Castillo José, Campos Francisco. 2016. Stroke. 47: 2386-2396 -
Resting-state functional MRI as a tool for evaluating brain hemodynamic responsiveness to external stimuli in rats
Paasonen Jaakko, Salo Raimo A, Huttunen Joanna K, Gröhn Olli. 2016. Magnetic resonance in medicine. 78: 1136-1146 -
Stroke onset time estimation from multispectral quantitative magnetic resonance imaging in a rat model of focal permanent cerebral ischemia
McGarry BL, Rogers HJ, Knight MJ, Jokivarsi KT, Sierra A, Gröhn OHJ, Kauppinen RA. 2016. International journal of stroke. 11: 677-82 -
Tailored Dual PEGylation of Inorganic Porous Nanocarriers for Extremely Long Blood Circulation in Vivo
Nissinen Tuomo, Näkki Simo, Laakso Hanne, Kuciauskas Dalius, Kaupinis Algirdas, Kettunen Mikko I, Liimatainen Timo, Hyvönen Mervi, Valius Mindaugas, Gröhn Olli, Lehto Vesa-Pekka. 2016. Acs applied materials and interfaces. 8: 32723-32731 -
Brain amyloidosis and BDNF deficiency have opposite effects on brain volumes in AßPP/PS1 mice both in vivo and ex vivo
Kärkkäinen Elisa, Lahtinen Hanna-Maija, Närväinen Johanna, Gröhn Olli, Tanila Heikki. 2015. Journal of Alzheimer's disease. 46: 926-946 -
Diffusion tensor imaging detects chronic microstructural changes in white and gray matter after traumatic brain injury in rat
Laitinen Teemu, Sierra Alejandra, Bolkvadze Tamuna, Pitkänen Asla, Gröhn Olli. 2015. Frontiers in neuroscience. 9: 12 p -
Early maternal alcohol consumption alters hippocampal DNA methylation, gene expression and volume in a mouse model
Heidi Marjonen, Alejandra Sierra, Anna Nyman, Vladimir Rogojin, Olli Gröhn, Anni-Maija Linden, Sampsa Hautaniemi, Nina Kaminen-Ahola. 2015. PLoS ONE. 10: e0124931 -
Imaging microstructural damage and plasticity in the hippocampus during epileptogenesis
Sierra A, Gröhn O, Pitkänen A. 2015. Neuroscience. 309: 162-172 -
Involvement of NMDA receptor subtypes in cortical spreading depression in rats assessed by fMRI
Shatillo Artem, Salo Raimo A, Giniatullin Rashid, Gröhn Olli H. 2015. Neuropharmacology. 93: 164-170 -
Levosimendan alone and in combination with valsartan prevents stroke in Dahl salt-sensitive rats
Levijoki Jouko, Kivikko Matti, Pollesello Piero, Sallinen Jukka, Hyttilä-Hopponen Minja, Kuoppamäki Mikko, Haasio Kristiina, Gröhn Olli, Miettinen Riitta, Puoliväli Jukka, Tähtivaara Leena, Yrjänheikki Juha, Haapalinna Antti. 2015. European journal of pharmacology. 750: 132-140 -
MRI relaxation in the presence of fictitious fields correlates with myelin content in normal rat brain
Hakkarainen Hanne, Sierra Alejandra, Mangia Silvia, Garwood Michael, Michaeli Shalom, Gröhn Olli, Liimatainen Timo. 2015. Magnetic resonance in medicine. first published online: 3 FEB 2015: 8 p -
Phase imaging in brain using SWIFT
Lehto Lauri Juhani, Garwood Michael, Grohn Olli, Corum Curtis Andrew. 2015. Journal of magnetic resonance. 252: 20-28 -
Decreased resting functional connectivity after traumatic brain injury in the rat
Mishra Asht Mangal, Bai Xiaoxiao, Sanganahalli Basavaraju G, Waxman Stephen G, Shatillo Olena, Gröhn Olli, Hyder Fahmeed, Pitkänen Asla, Blumenfeld Hal. 2014. PLoS ONE. 2014 Apr 18;9(4): e95280 -
Effect of lacosamide on structural damage and functional recovery after traumatic brain injury in rats
Pitkänen A, Immonen R, Ndode-Ekane X, Gröhn O, Stöhr T, Nissinen J. 2014. Epilepsy research. 2014 May;108(4): 653-65 -
Facile synthesis of biocompatible superparamagnetic mesoporous nanoparticles for imageable drug delivery
Nissinen Tuomo, Näkki Simo, Latikka Mika, Heinonen Markku, Liimatainen Timo, Xu Wujun, Ras Robin HA, Gröhn Olli, Riikonen Joakim, Lehto Vesa-Pekka. 2014. Microporous and mesoporous materials. 195: 2-8 -
Fast vascular component of cortical spreading depression revealed in rats by blood pulsation imaging
Teplov Victor, Shatillo Artem, Nippolainen Ervin, Gröhn Olli, Giniatullin Rashid, Kamshilin Alexei A. 2014. Journal of biomedical optics. 19: 046011-1-9 -
Measurement of T1 relaxation time of osteochondral specimens using VFA-SWIFT
Nissi Mikko J, Lehto Lauri J, Corum Curtis A, Idiyatullin Djaudat, Ellermann Jutta M, Gröhn Olli HJ, Nieminen Miika T. 2014. Magnetic resonance in medicine. -: - -
Opposite reactivity of meningeal versus cortical microvessels to the nitric oxide donor glyceryl trinitrate evaluated in vivo with two-photon imaging
Pryazhnikov E, Kislin M, Tibeykina M, Toptunov D, Ptukha A, Shatillo A, Gröhn O, Giniatullin R, Khiroug L. 2014. PLoS ONE. 2014 Feb 28;9(2):e89699: e89699 -
Parenchymal spin-lock fMRI signals associated with cortical spreading depression
Autio JA, Shatillo A, Giniatullin R, Gröhn OH. 2014. Journal of cerebral blood flow and metabolism. 34: 768-775 -
Posttraumatic epilepsy - Disease or comorbidity?
Pitkänen Asla, Kemppainen Samuli, Ndode-Ekane Xavier Ekolle, Huusko Noora, Huttunen Joanna K, Gröhn Olli, Immonen Riikka, Sierra Alejandra, Bolkvadze Tamuna. 2014. Epilepsy and behavior. 2014 Feb 11.: -- -
Progressive volume loss and white matter degeneration in cstb-deficient mice: a diffusion tensor and longitudinal volumetry MRI study
Manninen O, Laitinen T, Lehtimäki KK, Tegelberg S, Lehesjoki AE, Gröhn O, Kopra O. 2014. PLoS ONE. 2014 Mar 6;9(3):e90709.: e90709 -
Timing the ischaemic stroke by 1H-MRI: improved accuracy using absolute relaxation times over signal intensities
Rogers Harriet J, McGarry Bryony L, Knight Michael J, Jokivarsi Kimmo T, Gröhn Olli H, Kauppinen Risto A. 2014. Neuroreport. 2014 Oct 22;25(15): 1180-1185 -
Ultrasound imaging with bolus delivered contrast agent for the detection of angiogenesis and blood flow irregularities
Korpisalo P, Hytönen JP, Laitinen JT, Närväinen J, Rissanen TT, Gröhn OH, Ylä-Herttuala S. 2014. American journal of physiology : heart and circulatory physiology. 307: H1226-H1232 -
Cortical spreading depression induces oxidative stress in the trigeminal nociceptive system
Shatillo A, Koroleva K, Giniatullina R, Naumenko N, Slastnikova AA, Aliev RR, Bart G, Atalay M, Gu C, Khazipov R, Davletov B, Grohn O, Giniatullin R. 2013. Neuroscience. 2013 Sep 11;253C: 341-349 -
Diffusion tensor imaging of hippocampal network plasticity
Sierra A, Laitinen T, Gröhn O, Pitkänen A. 2013. Brain structure and function. 220: 781-801 -
In vivo magnetic resonance imaging and spectroscopy identifies oncolytic adenovirus responders
Hemminki O, Immonen R, Närväinen J, Kipar A, Paasonen J, Jokivarsi KT, Yli-Ollila H, Soininen P, Partanen K, Joensuu T, Parvianen S, Pesonen SK, Koski A, Vähä-Koskela M, Cerullo V, Pesonen S, Gröhn OH, Hemminki A. 2013. International journal of cancer. 6 DEC 2013: -- -
MRI biomarkers for post-traumatic epileptogenesis.
Immonen R, Kharatishvili I, Gröhn O, Pitkänen A. 2013. Journal of neurotrauma. 2013 Jul 15;30(14): 1305-9 -
Monitoring functional impairment and recovery after traumatic brain injury in rats by FMRI
Niskanen JP, Airaksinen AM, Sierra A, Huttunen JK, Nissinen J, Karjalainen PA, Pitkänen A, Gröhn OH. 2013. Journal of neurotrauma. : 546-56 -
Relaxation Along a Fictitious Field (RAFF) and Z-spectroscopy using Alternating-Phase Irradiation (ZAPI) in Permanent Focal Cerebral Ischemia in Rat
Jokivarsi KT, Liimatainen T, Kauppinen RA, Gröhn OH, Närväinen J. 2013. PLoS ONE. 2013 Jul 17;8(7):e69157: -- -
White Matter Degeneration with Unverricht-Lundborg Progressive Myoclonus Epilepsy: A Translational Diffusion-Tensor Imaging Study in Patients and Cystatin B-Deficient Mice
Manninen O, Koskenkorva P, Lehtimäki KK, Hyppönen J, Könönen M, Laitinen T, Kalimo H, Kopra O, Kälviäinen R, Gröhn O, Lehesjoki AE, Vanninen R. 2013. Radiology. : -- -
Detection of Calcifications In Vivo and Ex Vivo after Brain Injury in Rat Using SWIFT
Lehto LJ, Sierra A, Corum CA, Zhang J, Idiyatullin D, Pitkänen A, Garwood M, Gröhn O. 2012. Neuroimage. 2012 Jul 16;61(4): 761-72 -
Longitudinal rotating frame relaxation time measurements in infarcted mouse myocardium in vivo
Musthafa HS, Dragneva G, Lottonen L, Merentie M, Petrov L, Heikura T, Ylä-Herttuala E, Ylä-Herttuala S, Gröhn O, Liimatainen T. 2012. Magnetic resonance in medicine. 2012 Jun 26: -- -
Mild cognitive impairment associates with concurrent decreases in serum cholesterol and cholesterol-related lipoprotein subclasses
Tukiainen T, Jylänki P, Mäkinen VP, Gröhn O, Hallikainen M, Soininen H, Kivipelto M, Kaski K, Groop PH, Savolainen MJ, Pirttilä T, Soininen P, Ala-Korpela M. 2012. Journal of nutrition health and aging. 16: 631-635 -
Rats bred for low aerobic capacity become promptly fatigued and have slow metabolic recovery after stimulated, maximal muscle contractions
Torvinen S, Silvennoinen M, Piitulainen H, Närväinen J, Tuunanen P, Gröhn O, Koch LG, Britton SL, Kainulainen H. 2012. PLoS ONE. 2012;7(11):e48345: -- -
Simultaneous BOLD fMRI and local field potential measurements during kainic acid-induced seizures
Airaksinen AM, Hekmatyar SK, Jerome N, Niskanen JP, Huttunen JK, Pitkänen A, Kauppinen RA, Gröhn OH. 2012. Epilepsia. 2012 Jul;53(7): 1245-53 -
Chronic hyperperfusion and angiogenesis follow subacute hypoperfusion in the thalamus of rats with focal cerebral ischemia
Hayward Nick MEA, Yanev Pavel, Haapasalo Annakaisa, Miettinen Riitta, Hiltunen Mikko, Gröhn Olli, Jolkkonen Jukka. 2011. Journal of cerebral blood flow and metabolism. 31: 1119-1132 -
Diffusion tensor MRI with tract-based spatial statistics and histology reveals undiscovered lesioned areas in kainate model of epilepsy in rat
Sierra Alejandra, Laitinen Teemu, Lehtimäki Kimmo, Rieppo Lassi, Pitkänen Asla, Gröhn Olli. 2011. Brain structure and function. 216: 123-135 -
Evoked local field potentials can explain temporal variation in blood oxygenation level-dependent responses in rat somatosensory cortex
Huttunen Joanna K, Niskanen Juha-Pekka, Lehto Lauri J, Airaksinen Antti M, Niskanen Eini I, Penttonen Markku, Gröhn Olli. 2011. Nmr in biomedicine. 24: 209-215 -
Galactolipid deficiency in the early pathogenesis of neuronal ceroid lipofuscinosis model Cln8(mnd) : implications to delayed myelination and oligodendrocyte maturation
Kuronen M, Hermansson M, Manninen O, Zech I, Talvitie M, Laitinen T, Gröhn O, Somerharju P, Eckhardt M, Cooper JD, Lehesjoki AE, Lahtinen U, Kopra O. 2011. Neuropathology and applied neurobiology. 2012 Aug;38(5): 471-86 -
Glioma cell density in a rat gene therapy model gauged by water relaxation rate along a fictitious magnetic field. Magn. Reson. Med. 67: 269-277, 2012
Liimatainen T, Sierra A, Hanson T, Sorce DJ, Ylä-Herttuala S, Garwood M, Michaeli S, Gröhn O. 2011. Magnetic resonance in medicine. 2012 Jan;67(1): 269-277 -
Magnetic resonance imaging of regional hemodynamic and cerebrovascular recovery after lateral fluid-percussion brain injury in rats
Hayward Nick Mark Edward Alexander, Tuunanen Pasi, Immonen Riikka, Ndode-Ekane Xavier Ekolle, Pitkänen Asla, Gröhn Olli. 2011. Journal of cerebral blood flow and metabolism. 31: 166-177 -
Multimodal MRI assessment of damage and plasticity caused by status epilepticus in the rat brain
Gröhn O, Sierra A, Immonen R, Laitinen T, Lehtimäki K, Airaksinen A, Hayward N, Nairismagi J, Lehto L, Pitkänen A. 2011. Epilepsia. : 57-60 -
VEGFR-1 and -3 and angiopoietin receptor Tie2 targeted gene therapy prevents the growth of solid human ovarian cancer in mice compared to cotargeting Tie1 and Tie2
Sallinen H, Anttila M, Gröhn O, Koponen J, Hämäläinen K, Kholova I, Heikura T, Kosma VM, Heinonen S, Alitalo K, Ylä-Herttuala S. 2011. Cancer gene therapy. 18: 100-9 -
Association of chronic vascular changes with functional outcome after traumatic brain injury in rats
Hayward NM, Immonen R, Tuunanen PI, Ndode-Ekane XE, Gröhn O & Pitkänen A. 2010. Journal of neurotrauma. 27: 2203-2219 -
Cerebral blood volume alterations in the perilesional areas in the rat brain after traumatic brain injury¿comparison with behavioral outcome
Immonen R, Heikkinen T, Tähtivaara L, Nurmi A, Stenius TK, Puoliväli J, Tuinstra T, Phinney AL, Van Vliet B, Yrjänheikki J et al. 2010. Journal of cerebral blood flow and metabolism. 30: 1318 -1328 -
Correlating tissue outcome with quantitative multiparametric MRI of acute cerebral ischemia in rats
Jokivarsi KT, Hiltunen Y, Tuunanen PI, Kauppinen RA & Gröhn OH. 2010. Journal of cerebral blood flow and metabolism. 30: 415-427 -
Cotargeting of VEGFR-1 and -3 and angiopoietin receptor Tie2 reduces the growth of solid human ovarian cancer in mice
Sallinen H, Anttila M, Gröhn O, Koponen J, Hämäläinen K, Kholova I, Kosma VM, Heinonen S, Alitalo K & Ylä-Herttuala S. 2010. Cancer gene therapy. 18: 100-109 -
Diffusion tensor MRI of axonal plasticity in the rat hippocampus
Laitinen T, Sierra A, Pitkänen A & Gröhn O. 2010. Neuroimage. 51: 251-530 -
Elevated cerebral blood flow and vascular density in the amygdala after status epilepticus in rats
Hayward NM, Ndode-Ekane XE, Kutchiashvili N, Gröhn O Pitkänen A.. 2010. Neuroscience letters. 484: 39-42 -
Estimation of the onset time of cerebral ischemia using T1rho and T2 MRI in rats
Jokivarsi KT, Hiltunen Y, Gröhn H, Tuunanen P, Gröhn OH & Kauppinen RA. 2010. Stroke. 41: 2335-2340 -
NMR relaxation times of trabecular bone - reproducibility, relationships to tissue structure and effects of sample freezing
Prantner V, Isaksson H, Närväinen J, Lammentausta E, Nissi MJ, Avela J, Gröhn OH, Jurvelin JS. 2010. Physics in medicine and biology. 55(2010): 1-13 -
Simultaneous fMRI and local field potential measurements during epileptic seizures in medetomidine-sedated rats using raser pulse sequence
Airaksinen AM, Niskanen JP, Chamberlain R, Huttunen JK, Nissinen J, Garwood M, Pitkänen A & Gröhn O. 2010. Magnetic resonance in medicine. 64: 1191-1199 -
Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy
Ndode-Ekane XE, Hayward N, Gröhn O & Pitkänen A. 2010. Neuroscience. 166: 312-332 -
(Strept)avidin-displaying lentiviruses as versatile tools for targeting and dual imaging of gene delivery
Kaikkonen MU, Lesch HP, Pikkarainen J, Räty JK, Vuorio T, Huhtala T, Taavitsainen M, Laitinen T, Tuunanen P, Gröhn O, Närvänen A, Airenne KJ, Ylä-Herttuala S. 2009. Gene therapy. 16: 894-904 -
Distinct MRI pattern in lesional and perilesional area after traumatic brain injury in rat - 11 months follow-up
Immonen RJ, Kharatishvili I, Niskanen J-P, Gröhn H, Pitkänen A, Gröhn OHJ. 2009. Experimental neurology. 215: 29-40 -
From traumatic brain injury to posttraumatic epilepsy: what animal models tell us about the process and treatment options
Pitkänen A, Immonen RJ, Gröhn OH, Kharatishvili I. 2009. EPILEPSIA. SUPPLEMENT. 50: 21-29 -
Quantitative MRI predicts long-term structural and functional outcome after experimental traumatic brain injury
Immonen RJ, Kharatishvili I, Gröhn H, Pitkänen A, Gröhn OHJ. 2009. Neuroimage. 45: 1-9 -
Quantitative T2 mapping as a potential marker for the initial assessment of the severity of damage after traumatic brain injury in rat
Kharatishvili I, Sierra A, Immonen RJ, Gröhn OHJ, Pitkänen A. 2009. Experimental neurology. 217: 154-164 -
Quantitative assessment of water pools by T1rho and T2rho MRI in acute cerebral ischemia of the rat
Jokivarsi KT, Niskanen J-P, Michaeli S, Gröhn HI, Garwood M, Kauppinen RA, Gröhn OH. 2009. Journal of cerebral blood flow and metabolism. 29: 206-216 -
1H MR spectroscopic imaging of phospholipase-mediated membrane lipid release in apoptotic rat glioma in vivo
Liimatainen TJ, Erkkilä AT, Valonen P, Vidgren H, Lakso M, Wong G, Gröhn OHJ, Ylä-Herttuala S, Hakumäki JM. 2008. Magnetic resonance in medicine. 59: 1232-1238 -
A multi-metabolite analysis of serum by 1H NMR spectroscopy: Early systemic signs of Alzheimer's disease
Tukiainen T, Tynkkynen T, Mäkinen V-P, Jylänki P, Kangas A, Hokkanen J, Vehtari A, Gröhn O, Hallikainen M, Soininen H, Kivipelto M, Groop P-H, Kaski K, Laatikainen R, Soininen P, Pirttilä T, Ala-Korpela M, Soininen H, Pirttilä. 2008. Biochemical and biophysical research communications. 375: 356-361 -
Coupling between simultaneously recorded BOLD response and neuronal activity in the rat somatosensory cortex
Huttunen JK, Gröhn O, Penttonen M. 2008. Neuroimage. 39: 775-785 -
High-resolution ultrasound perfusion imaging of therapeutic angiogenesis
Rissanen TT, Korpisalo P, Karvinen H, Liimatainen T, Laidinen S, Gröhn OH, Ylä-Herttuala S. 2008. JACC : cardiovascular imaging. 1: 83 - 91 -
Interleukin-1 exacerbates focal cerebral ischemia and reduces ischemic brain temperature in the rat
Parry-Jones AR, Liimatainen T, Kauppinen RA, Gröhn OH, Rothwell NJ. 2008. Magnetic resonance in medicine. 59: 1239-1249 -
Manganese enhanced MRI detects mossy fiber sprouting rather than neurodegeneration, gliosis or seizure-activity in the epileptic rat hippocampus
Immonen RJ, Kharatishvili I, Sierra A, Einula C, Pitkänen A, Gröhn OH. 2008. Neuroimage. 40: 1718-1730 -
T2, Carr-Purcell T2 and T1rho of fat and water as surrogate markers of trabecular bone structure
Lammentausta E, Silvast TS, Närväinen J, Jurvelin JS, Nieminen MT, Gröhn OHJ. 2008. Physics in medicine and biology. 53: 543-555 -
Therapeutic angiogenesis with placental growth factor improves exercise tolerance of ischaemic rabbit hindlimbs
Korpisalo P, Rissanen TT, Bengtsson T, Liimatainen T, Laidinen S, Karvinen H, Markkanen JE, Gröhn OH, Ylä-Herttuala S. 2008. Cardiovascular research. 80: 263-270 -
Water spin dynamics during apoptotic cell death in glioma gene therapy probed by T1rho and T2rho
Sierra A, Michaeli S, Niskanen J-P, Valonen PK, Gröhn HI, Ylä-Herttuala S, Garwood M, Gröhn OH. 2008. Magnetic resonance in medicine. 59: 1311-1319 -
Adenovirus-mediated gene transfer of human vascular endothelial growth factor-d induces transient angiogenic effects in mouse hind limb muscle
Kholová I, Koota S, Kaskenpää N, Leppänen P, Närväinen J, Kavec M, Rissanen TT, Hazes T, Korpisalo P, Gröhn O, Ylä-Herttuala S. 2007. Human gene therapy. 18: 232-244 -
Epileptogenesis in experimental models
Pitkänen A, Kharatisvili I, Karhunen H, Lukasiuk K, Immonen R, Nairismägi J, Gröhn O, Nissinen J. 2007. EPILEPSIA. SUPPLEMENT. 48: 13-20 -
Low spin-lock field T1 relaxation in the rotating frame as a sensitive MR imaging marker for gene therapy treatment response in rat glioma
Kettunen MI, Sierra A, Närväinen MJ, Valonen PK, Ylä-Herttuala S, Kauppinen RA, Gröhn OHJ. 2007. Radiology. 243: 796-803 -
Magnetic resonance imaging in animal models of epilepsy-noninvasive detection of structural alterations
Gröhn O, Pitkänen A. 2007. EPILEPSIA. SUPPLEMENT. 48: 3-10 -
Non-invasive imaging in gene therapy
Räty JK, Liimatainen T, Kaikkonen MU, Gröhn O, Airenne KJ, Ylä-Herttuala S. 2007. Molecular therapy. 15: 1579-1586 -
Proton transfer ratio, lactate, and intracellular pH in acute cerebral ischemia
Jokivarsi KT, Gröhn HI, Gröhn OH, Kauppinen RA. 2007. Magnetic resonance in medicine. 57: 647-653 -
Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis
Kharatishvili I, Immonen R, Gröhn O, Pitkänen A. 2007. Brain. 130: 3155-3168 -
Spectroscopic imaging with volume selection by unpaired adiabatic pi pulses: Theory and application
Valette J, Park J-Y, Gröhn O, Ugurbil K, Garwood M, Henry P-G. 2007. Journal of magnetic resonance. 189: 1-12 -
Subacute hemorrhage and resolution of edema in Rose Bengal stroke model in rats coincides with improved sensorimotor functions
Jolkkonen J, Jokivarsi K, Laitinen T, Gröhn O. 2007. Neuroscience letters. 428: 99-102 -
Antioxidant pyrrolidine dithiocarbamate activates Akt-GSK signaling and is neuroprotective in neonatal hypoxia¿ischemia
Nurmi A, Goldsteins G, Närväinen J, Pihlaja R, Ahtoniemi T, Gröhn O, Koistinaho J. 2006. Free radical biology and medicine. 40: 1776-1784 -
Manganese-enhanced magnetic resonance imaging of mossy fiber plasticity in vivo
Nairismägi J, Pitkänen A, Narkilahti S, Huttunen J, Kauppinen RA, Gröhn OHJ. 2006. Neuroimage. 30: 130-135 -
Ultra-short echo time spectroscopic imaging in rats: implications for monitoring lipids in glioma gene therapy
Liimatainen T, Hakumäki J, Tkác I, Gröhn O. 2006. Nmr in biomedicine. 19: 554-559 -
Blood flow remodels growing vasculature during vascular endothelial growth factor gene therapy and determines between capillary arterialization and sprouting angiogenesis
Rissanen TT, Korpisalo P, Markkanen JE, Liimatainen T, Ordén M-R, Kholová I, de Goede A, Heikura T, Gröhn OH, Ylä-Herttuala S. 2005. Circulation. 112: 3937-3946 -
Dispersion of cerebral on-resonance T1 in the rotating frame (T1 rho) in global ischaemia
Kettunen MI, Kauppinen RA, Gröhn OHJ. 2005. Applied magnetic resonance. 29: 89-106 -
Dynamic dephasing changes in developing ischemic cerebral infarction in rats studied by Carr-Purcell T2 magnetic resonance imaging
Kavec M, Gröhn OHJ, Gröhn HI, Garwood M, Kauppinen RA. 2005. Magnetic resonance in medicine. 53: 960-964 -
Exchange-influenced T2rho contrast in human brain images measured with adiabatic radio frequency pulses
Michaeli S, Gröhn H, Gröhn O, Sorce DJ, Kauppinen R, Springer CS Jr, Ugurbil K, Garwood M. 2005. Magnetic resonance in medicine. 53: 823-829 -
Experimental febrile seizures require an undetermined factor for induction of hippocampal sclerosis in immature rat brain
Pitkänen A, Gröhn O. 2005. Epilepsy currents -
High-resolution magic-angle-spinning 1H NMR spectroscopy reveals different responses in choline-containing metabolites upon gene therapy-induced programmed cell death in rat brain glioma
Valonen PK, Griffin JL, Lehtimäki KK, Liimatainen T, Nicholson JK, Gröhn OHJ, Kauppinen RA. 2005. Nmr in biomedicine. 18: 252-259 -
Quantitative T(1rho) and adiabatic Carr-Purcell T2 magnetic resonance imaging of human occipital lobe at 4 T
Gröhn HI, Michaeli S, Garwood M, Kauppinen RA, Gröhn OHJ. 2005. Magnetic resonance in medicine. 54: 14-19 -
Tumour gene therapy monitoring using magnetic resonance imaging and spectroscopy
Kettunen MI, Gröhn OHJ. 2005. Current gene therapy. 5: 685-696 -
Acute cerebral ischemia in rats studied by Carr-Purcell spin-echo magnetic resonance imaging: Assessment of blood oxygenation level-dependent and tissue effects on the transverse relaxation
Kavec M, Gröhn OHJ, Kettunen MI, Silvennoinen MJ, Garwood M, Kauppinen RA. 2004. Magnetic resonance in medicine. 51: 1138-1146 -
B0 dependence of the on-resonance longitudinal relaxation time in the rotating frame (T1rho) in protein phantoms and rat brain in vivo
Mäkelä HI, De Vita E, Gröhn OHJ, Kettunen MI, Kavec M, Lythgoe M, Garwood M, Ordidge R, Kauppinen RA. 2004. Magnetic resonance in medicine. 51: 4-8 -
In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent
Jack CR Jr, Garwood M, Wengenack TM, Borowski B, Curran GL, Lin J, Adriany G, Gröhn OHJ, Grimm R, Poduslo JF. 2004. Magnetic resonance in medicine. 52: 1263-1271 -
Progression of brain damage after status epilepticus and its association with epileptogenesis: a quantitative MRI study in a rat model of temporal lobe epilepy
Nairismägi J, Gröhn OHJ, Kettunen MI, Nissinen J, Kauppinen RA, Pitkänen A. 2004. Epilepsia. 45: 1024-1034 -
Quantitative T1rho NMR spectroscopy of rat cerebral metabolites in vivo: Effects of global ischemia
Kettunen MI, Gröhn OHJ, Kauppinen RA. 2004. Magnetic resonance in medicine. 51: 875-880 -
Water diffusion in a rat glioma during ganciclovir-thymidine kinase gene therapy-induced programmed cell death in vivo: Correlation with cell density
Valonen PK, Lehtimäki KK, Väisänen TH, Kettunen MI, Gröhn OHJ, Ylä-Herttuala S, Kauppinen RA. 2004. Journal of magnetic resonance imaging. 19: 389-396 -
Assignment of 1H nuclear magnetic resonance visible polyunsaturated fatty acids in BT4C gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death
Griffin JL, Lehtimäki KK, Valonen PK, Gröhn OHJ, Kettunen MI, Ylä-Herttuala S, Pitkänen A, Nicholson JK, Kauppinen RA. 2003. Cancer research. 63: 3195-3201 -
Metabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro*
Lehtimäki KK, Valonen PK, Griffin JL, Väisänen TH, Gröhn OHJ, Kettunen MI, Vepsäläinen J, Ylä-Herttuala S, Nicholson J, Kauppinen RA. 2003. Journal of biological chemistry. 278: 45915-45923 -
Novel magnetic resonance imaging contrasts for monitoring response to gene therapy in rat glioma
Gröhn OHJ, Valonen PK, Lehtimäki KK, Väisänen TH, Kettunen MI, Ylä-Herttuala S, Kauppinen RA, Garwood M. 2003. Cancer research. 63: 7571-7574 -
On- and off-resonance T1rho MRI in acute cerebral ischemia of the rat
Gröhn OHJ, Mäkelä HI, Lukkarinen JA, DelaBarre L, Lin J, Garwood M, Kauppinen RA. 2003. Magnetic resonance in medicine. 49: 172-176 -
Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice
Kaasinen SK, Gröhn OHJ, Keinänen TA, Alhonen L, Jänne J. 2003. Experimental neurology. 183: 645-652 -
Diazepam does not reduce infarct size in rats subjected to transient occlusion of the middle cerebral artery when normothermia is maintained
Kuhmonen J, Lukkarinen J, Gröhn O, Jolkkonen J, Sivenius J. 2002. Journal of pharmacy and pharmacology. 54: 1565-1569 -
Early gene therapy - induced apoptotic response in BT4C gliomas by magnetic resonance relaxation contrast T1 in the rotating frame
Hakumäki JM, Gröhn OHJ, Tyynelä K, Valonen P, Ylä-Herttuala S, Kauppinen RA. 2002. Cancer gene therapy. 9: 338-345 -
Effects of intracellular pH, blood, and tissue oxygen tension on T-1rho relaxation in rat brain
Kettunen MI, Gröhn OHJ, Silvennoinen MJ, Penttonen M, Kauppinen RA. 2002. Magnetic resonance in medicine. 48: 470-477 -
Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy
Pitkänen A, Nissinen J, Nairismägi J, Lukasiuk K, Gröhn OHJ, Miettinen R, Kauppinen R. Teoksessa: Sutula T, Pitkänen A(toim.) , 2002. Do Seizures Damage the Brain. s. 67-83. Elsevier -
Quantitative T (1rho) and magnetization transfer magnetic resonance imaging of acute cerebral ischemia in the rat
Mäkelä HI, Kettunen MI, Gröhn OHJ, Kauppinen RA. 2002. Journal of cerebral blood flow and metabolism. 22: 547-558 -
Quantitative assessment of the balance between oxygen delivery and consumption in the rat brain after transient ischemia with T2-BOLD magnetic resonance imaging
Kettunen MI, Gröhn OHJ, Silvennoinen MJ, Penttonen M, Kauppinen RA. 2002. Journal of cerebral blood flow and metabolism. 22: 262-270 -
Assessment of brain tissue viability in acute ischemic stroke by BOLD NMR
Gröhn OHJ, Kauppinen RA. 2001. Nmr in biomedicine. 14: 432-440 -
Cerebral T1rho relaxation time increases immediately upon global ischemia in the rat independently of blood glucose and anoxic depolarization
Kettunen MI, Gröhn OHJ, Penttonen M, Kauppinen RA. 2001. Magnetic resonance in medicine. 46: 565-572 -
Proton exchange as a relaxation mechanism for T1 in the rotating frame in native and immobilized protein solutions
Mäkelä HI, Gröhn OHJ, Kettunen MI, Kauppinen RA. 2001. Biochemical and biophysical research communications. 289: 813-818 -
Use of spin echo T2 BOLD in assessment of cerebral misery perfusion at 1.5 T
Kavec M, Gröhn OHJ, Kettunen MI, Silvennoinen MJ, Penttonen M, Kauppinen RA. 2001. Magnetic resonance materials in physics biology and medicine. 12: 32-39 -
Early detection of irreversible cerebral ischemia in the rat using dispersion of the magnetic resonance imaging relaxation time, T1rho
Gröhn OHJ, Kettunen MI, Mäkelä HI, Penttonen M, Pitkänen A, Lukkarinen JA, Kauppinen RA. 2000. Journal of cerebral blood flow and metabolism. 20: 1457-1466 -
Graded reduction of cerebral blood flow in rat as detected by the nuclear magnetic resonance relaxation time T2: a theoretical and experimental approach
Gröhn OHJ, Kettunen MI, Penttonen M, Oja JME, van Zijl PCM, Kauppinen RA. 2000. Journal of cerebral blood flow and metabolism. 20: 316-326 -
Interrelations of T1 and diffusion of water in acute cerebral ischemia of the rat
Kettunen MI, Gröhn OHJ, Lukkarinen JA, Vainio P, Silvennoinen MJ, Kauppinen RA. 2000. Magnetic resonance in medicine. 44: 833-839 -
Magnetic Resonance Imaging of Acute Cerebral Ischaemia. Novel Haemodynamic and Parenchymal Indicators of Reversible and Irreversible Ischaemia
Gröhn O. 2000. Kuopion yliopiston julkaisuja C. Luonnontieteet ja ympäristötieteet -
Transgenic mice overexpressing truncated trkB neurotophin receptors in neurons show incresed susceptibility to cortical injury after focal cerebral inschemia
Saarelainen T, Lukkarinen JA, Koponen S, Gröhn OHJ, Jolkkonen J, Koponen E, Haapasalo A, Alhonen L, Wong G, Koistinaho J, Kauppinen RA, Castrén E. 2000. Molecular and cellular neuroscience. 16: 87-96 -
Enhanced ornithine decarboxylase activity is associated with attenuated rate of damage evolution and reduction of infarct volume in transient middle cerebral artery occlusion in the rat
Lukkarinen JA, Gröhn OHJ, Alhonen LI, Jänne J, Kauppinen RA. 1999. Brain research. 826: 325-329 -
Quantitative magnetic resonance imaging assessment of cerebral ischemia in rat using on-resonance T1 in the rotating frame
Gröhn OHJ, Lukkarinen JA, Silvennoinen MJ, Pitkänen A, van Zijl PCM, Kauppinen RA. 1999. Magnetic resonance in medicine. 42: 268-276 -
Monitoring thymidine kinase and ganciclovir-induced changes in rat malignant glioma in vivo by nuclear magnetic resonance imaging
Poptani H, Puumalainen A-M, Gröhn OH, Loimas S, Kainulainen R, Ylä-Herttuala S, Kauppinen RA. 1998. Cancer gene therapy. 5: 101-109 -
Neuroprotective role of ornithine decarboxylase activation in transient focal cerebral ischaemia: a study using ornithine decarboxylase-overexpressing transgenic rats
Lukkarinen JA, Kauppinen RA, Gröhn OHJ, Oja JME, Sinervirta R, Järvinen A, Alhonen LI, Jänne J. 1998. European journal of neuroscience. 10: 2046-2055 -
Noninvasive detection of cerebral hypoperfusion and reversible ischemia from reductions in the magnetic resonance imaging relaxation time, T2
Gröhn OHJ, Lukkarinen JA, Oja JME, van Zijl PCM, Ulatowski JA, Traystman RJ, Kauppinen RA. 1998. Journal of cerebral blood flow and metabolism. 18: 911-920 -
Transgenic rats as models for studying the role of ornithine decarboxylase expression in permanent middle cerebral artery occlusion
Lukkarinen J, Gröhn OHJ, Sinervirta R, Järvinen A, Kauppinen RA, Jänne J, Alhonen LI. 1997. Stroke. 28: 639-645 -
Increased macromolecular resonances in the rat cerebral cortex during severe energy failure as detected by 1H nuclear magnetic resonance spectroscopy
Hakumäki JM, Gröhn OHJ, Pirttilä T-RM, Kauppinen RA. 1996. Neuroscience letters. 212: 151-154