OLLI GRöHN

Contact info

Research groups - UEF

• 
  Biomedical MRI
• 
  Neuro-Innovation

Publications

• Bencurova, Petra; Laakso, Hanne; Salo, Raimo A; Paasonen, Ekaterina; Manninen, Eppu; Paasonen, Jaakko; Michaeli, Shalom; Mangia, Silvia; Bares, Martin; Brazdil, Milan; Kubova, Hana; Gröhn, Olli. 2021. Infantile status epilepticus disrupts myelin development Neurobiology of disease 2022; 162: 105566. 2021
• Laakso, Hanne; Lehto, Lauri J; Paasonen, Jaakko; Salo, Raimo; Canna, Antonietta; Lavrov, Igor; Michaeli, Shalom; Gröhn, Olli; Mangia, Silvia. 2021. Spinal cord fMRI with MB-SWIFT for assessing epidural spinal cord stimulation in rats Magnetic resonance in medicine 86 4: 2137-2145. 2021
• Canna, Antonietta; Lehto, Lauri J; Wu, Lin; Sang, Sheng; Laakso, Hanne; Ma, Jun; Filip, Pavel; Zhang, Yuan; Gröhn, Olli; Esposito, Fabrizio; Chen, Clark C; Lavrov, Igor; Michaeli, Shalom; Mangia, Silvia. 2021. Brain fMRI during orientation selective epidural spinal cord stimulation Scientific reports 11 1: 5504. 2021
• Yasmin, Amna; Pitkänen, Asla; Andrade, Pedro; Paananen, Tomi; Gröhn, Olli; Immonen, Riikka. 2021. Post-injury ventricular enlargement associates with iron in choroid plexus but not with seizure susceptibility nor lesion atrophy - 6-month MRI follow-up after experimental traumatic brain injury Brain structure and function 2022; 227 1: 145-158. 2021
• Stenroos, Petteri; Pirttimäki, Tiina; Paasonen, Jaakko; Paasonen, Ekaterina; Salo, Raimo A; Koivisto, Hennariikka; Natunen, Teemu; Mäkinen, Petra; Kuulasmaa, Teemu; Hiltunen, Mikko; Tanila, Heikki; Gröhn, Olli. 2021. Isoflurane affects brain functional connectivity in rats 1 month after exposure Neuroimage 234: 117987. 2021
• Relaxation Anisotropy in Biological Tissues. Hänninen N; Nissi MJ; Hanni M; Gröhn OHJ; Nieminen MT; Liimatainen T / Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition. 2021. 2021
• Miocchi, Paolo; Sierra, Alejandra; Maugeri, Laura; Stefanutti, Eleonora; Abdollahzadeh, Ali; Mangini, Fabio; Moraschi, Marta; Bukreeva, Inna; Massimi, Lorenzo; Brun, Francesco; Tohka, Jussi; Gröhn, Olli; Mittone, Alberto; Bravin, Alberto; Nicaise, Charles; Giove, Federico; Cedola, Alessia; Fratini, Michela. 2021. Steerable3D: An ImageJ plugin for neurovascular enhancement in 3-D segmentation Physica medica 81: 197-209. 2021
• Manninen, Eppu; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkänen, Asla. 2021. Acute thalamic damage as a prognostic biomarker for post-traumatic epileptogenesis Epilepsia 62 8: 1852-1864. 2021
• Hyppönen, Viivi; Stenroos, Petteri; Nivajärvi, Riikka; Ardenkjaer-Larsen, Jan Henrik; Gröhn, Olli; Paasonen, Jaakko; Kettunen, Mikko I. 2021. Metabolism of hyperpolarised [1-13C]pyruvate in awake and anaesthetised rat brains Nmr in biomedicine 2022; 35 2: e4635. 2021
• Holikova, Klara; Laakso, Hanne; Salo, Raimo; Shatillo, Artem; Nurmi, Antti; Bares, Martin; Vanicek, Jiri; Michaeli, Shalom; Mangia, Silvia; Sierra, Alejandra; Gröhn, Olli. 2021. RAFF-4, Magnetization Transfer and Diffusion Tensor MRI of Lysophosphatidylcholine Induced Demyelination and Remyelination in Rats Frontiers in neuroscience 15: 625167. 2021
• Hanhela, Matti; Gröhn, Olli; Kettunen, Mikko; Niinimäki, Kati; Vauhkonen, Marko; Kolehmainen, Ville. 2021. Data-Driven Regularization Parameter Selection in Dynamic MRI Journal of imaging 7 2: 38. 2021
• Genicio, Nuria; Bañobre-López, Manuel; Gröhn, Olli; Gallo, Juan. 2021. Ratiometric magnetic resonance imaging: Contrast agent design towards better specificity and quantification Coordination chemistry reviews 447: 214150. 2021
• Dvoráková, Lenka; Stenroos, Petteri; Paasonen, Ekaterina; Salo, Raimo A.; Paasonen, Jaakko; Gröhn, Olli. 2021. Light sedation with short habituation time for large-scale functional magnetic resonance imaging studies in rats Nmr in biomedicine First published: 27 December 2021: 1 - 13. 2021
• De Feo, Riccardo; Shatillo, Artem; Sierra, Alejandra; Valverde, Juan Miguel; Gröhn, Olli; Giove, Federico; Tohka, Jussi. 2021. Automated joint skull-stripping and segmentation with Multi-Task U-Net in large mouse brain MRI databases Neuroimage 229: 117734. 2021
• Chary Karthik, Narvaez Omar, Salo Raimo A, San Martín Molina Isabel, Tohka Jussi, Aggarwal Manisha, Gröhn Olli, Sierra Alejandra. 2021. Microstructural Tissue Changes in a Rat Model of Mild Traumatic Brain Injury Frontiers in neuroscience 15: 746214. 2021
• Nivajärvi, R; Olsson, V; Hyppönen, V; Bowen, S; Leinonen, HM; Lesch, HP; Ardenkjaer-Larsen, JH; Gröhn, OHJ; Ylä-Herttuala, S; Kettunen, MI. 2020. Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1-13 C]pyruvate Nmr in biomedicine 33 4: e4250. 2020
• Valverde, Juan Miguel; Shatillo, Artem; De Feo, Riccardo; Gröhn, Olli; Sierra, Alejandra; Tohka, Jussi. 2020. RatLesNetv2: A Fully Convolutional Network for Rodent Brain Lesion Segmentation Frontiers in neuroscience 14: 610239. 2020
• San Martín Molina, Isabel; Salo, Raimo A; Abdollahzadeh, Ali; Tohka, Jussi; Gröhn, Olli; Sierra, Alejandra. 2020. In vivo diffusion tensor imaging in acute and subacute phases of mild traumatic brain injury in rats eNeuro 7 3: ENEURO.0476-19.2020. 2020
• Salo, Raimo A; Belevich, Ilya; Jokitalo, Eija; Gröhn, Olli; Sierra, Alejandra. 2020. Assessment of the structural complexity of diffusion MRI voxels using 3D electron microscopy in the rat brain Neuroimage 225: 117529. 2020
• Paasonen, J; Laakso, H; Pirttimäki, T; Stenroos, P; Salo, RA; Zhurakovskaya, E; Lehto, LJ; Tanila, H; Garwood, M; Michaeli, S; Idiyatullin, D; Mangia, S; Gröhn, O. 2020. Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat Neuroimage 206: 116338. 2020
• van Vliet, Erwin A; Ndode-Ekane, Xavier Ekolle; Lehto, Lauri J; Gorter, Jan A; Andrade, Pedro; Aronica, Eleonora; Gröhn, Olli; Pitkänen, Asla. 2020. Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury Neurobiology of disease 145: 1-20. 2020
• Manninen, Eppu Matias; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra Lopez, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkanen, Asla. 2020. Early increase in cortical T2 relaxation is a prognostic biomarker for the evolution of severe cortical damage, but not for epileptogenesis, after experimental traumatic brain injury Journal of neurotrauma 37 23: 2580-2594. 2020
• Koponen, Lari M; Stenroos, Matti; Nieminen, Jaakko O; Jokivarsi, Kimmo; Gröhn, Olli; Ilmoniemi, Risto J. 2020. Individual head models for estimating the TMS-induced electric field in rat brain Scientific reports 10 1: 17397. 2020
• Hanhela, Matti; Kettunen, Mikko; Gröhn, Olli; Vauhkonen, Marko; Kolehmainen, Ville. 2020. Temporal Huber Regularization for DCE-MRI Journal of mathematical imaging and vision 62: 1334-1346. 2020
• Fratini, Michela; Abdollahzadeh, Ali; DiNuzzo, Mauro; Salo, Raimo; Maugeri, Laura; Cedola, Alessia; Giove, Federico; Gröhn, Olli; Tohka, Jussi; Sierra, Alejandra. 2020. Multiscale Imaging Approach for Studying the Central Nervous System: Methodology and Perspective Frontiers in neuroscience 14: 72. 2020
• A Computational Diffusion MRI Framework for Biomarker Discovery in a Rodent Model of Post-Traumatic Epileptogenesis. Cabeen, Ryan P; Immonen, Riikka; Harris, Neil G; Gröhn, Olli; Smith, Gregory; Manninen, Eppu; Garner, Rachael; Duncan, Dominique; Pitkänen, Asla; Toga, Arthur W / 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI). 2020. 2020
• Lehto, Lauri; Canna, Antonietta; Wu, Lin; Sierra, Alejandra; Zhurakovskaya, E; Ma, Jun; Pearce, Clairice; Shaio, Maple; Filip, Pavel; Johnson, Matthew; Low, Walter; Gröhn, Olli; Tanila, Heikki; Mangia, Silvia; Michaeli, Shalom. 2020. Orientation selective deep brain stimulation of the subthalamic nucleus in rats Neuroimage 213: 116750. 2020
• Vespa, PM; Shrestha, V; Abend, N; Agoston, D; Au, A; Bell, MJ; Bleck, TP; Blanco, MB; Claassen, J; Diaz-Arrastia, R; Duncan, D; Ellingson, B; Foreman, B; Gilmore, EJ; Hirsch, L; Hunn, M; Kamnaksh, A; McArthur, D; Morokoff, A; O'Brien, T; et al. (incl. Gröhn, Olli). 2019. The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol Neurobiology of disease 123: 110-114. 2019
• Zhurakovskaya, Ekaterina; Leikas, Juuso; Pirttimäki, Tiina; Casas Mon, Francesc; Gynther, Mikko; Aliev, Rubin; Rantamäki, Tomi; Tanila, Heikki; Forsberg, Markus M; Gröhn, Olli; Paasonen, Jaakko; Jalkanen, Aaro J. 2019. Sleep-State Dependent Alterations in Brain Functional Connectivity under Urethane Anesthesia in a Rat Model of Early-Stage Parkinson's Disease eNeuro 6 1: 1-12. 2019
• Zhurakovskaya, E; Ishchenko, I; Gureviciene, I; Aliev, R; Gröhn, O; Tanila, H. 2019. Impaired hippocampal-cortical coupling but preserved local synchrony during sleep in APP/PS1 mice modeling Alzheimer's disease Scientific reports 9 1: 5380. 2019
• Yasmin, Amna; Pitkänen, Asla; Jokivarsi, Kimmo; Poutiainen, Pekka; Gröhn, Olli; Immonen, Riikka. 2019. MRS Reveals Chronic Inflammation in T2w MRI-Negative Perilesional Cortex - A 6-Months Multimodal Imaging Follow-Up Study Frontiers in neuroscience 13: 863. 2019
• Knight, MJ; Damion, RA; McGarry, BL; Bosnell, R; Jokivarsi, KT; Gröhn, OHJ; Jezzard, P; Harston, GWJ; Carone, D; Kennedy, J; El-Tawil, S; Elliot, J; Muir, KW; Clatworthy, P; Kauppinen, RA. 2019. Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain Biomedical spectroscopy and imaging 8 1-2: 11-28. 2019
• Mikhailov, N; Leskinen, J; Fagerlund, I; Poguzhelskaya, E; Giniatullina, R; Gafurov, O; Malm, T; Karjalainen, T; Gröhn, O; Giniatullin, R. 2019. Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine? Neuropharmacology 149: 113-123. 2019
• Immonen, R; Smith, G; Brady, RD; Wright, D; Johnston, L; Harris, NG; Manninen, E; Salo, R; Branch, C; Duncan, D; Cabeen, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Shultz, SR; Andrade, P; Puhakka, N; Staba, RJ; O'Brien, TJ; et al.. 2019. Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis Epilepsy research 150: 46-57. 2019
• Automatic Rodent Brain MRI Lesion Segmentation with Fully Convolutional Networks. Valverde, JM; Shatillo, A; De Feo, R; Gröhn, O; Sierra, A; Tohka, J / Machine Learning in Medical Imaging. MLMI 2019. 2019. 2019
• Anwer, M; Immonen, R; Hayward, NMEA; Ndode-Ekane, XE; Puhakka, N; Gröhn, O; Pitkänen, A. 2019. Lateral fluid-percussion injury leads to pituitary atrophy in rats Scientific reports 9 1: 11819. 2019
• Shatillo, A; Lipponen, A; Salo, RA; Tanila, H; Verkhratsky, A; Giniatullin, R; Gröhn, OH. 2018. Spontaneous BOLD waves - A novel hemodynamic activity in Sprague-Dawley rat brain detected by functional magnetic resonance imaging Journal of cerebral blood flow and metabolism 2019; 39 10: 1949-1960. 2018
• Stenroos, Petteri; Paasonen, Jaakko; Salo, Raimo A; Jokivarsi, Kimmo; Shatillo, Artem; Tanila, Heikki; Gröhn, Olli. 2018. Awake Rat Brain Functional Magnetic Resonance Imaging Using Standard Radio Frequency Coils and a 3D Printed Restraint Kit Frontiers in Neuroscience 12: 548. 2018
• State estimation in dynamic MRI. Wettenhovi, Ville-Veikko; Kolehmainen, Ville; Huttunen, Joanna; Kettunen, Mikko; Gröhn, Olli; Vauhkonen, Marko / 2018 IEEE Nuclear Science Symposium and Medical Imaging (NSS/MIC): Conference Proceedings. 2018. 2018
• Slopsema, Julia P; Peña, Edgar; Patriat, Remi; Lehto, Lauri J; Gröhn, Olli; Mangia, Silvia; Harel, Noam; Michaeli, Shalom; Johnson, Matthew D. 2018. Clinical deep brain stimulation strategies for orientation-selective pathway activation Journal of Neural Engineering 15 5: 056029. 2018
• Huttunen, JK; Airaksinen, AM; Barba, C; Colicchio, G; Niskanen, JP; Shatillo, A; Sierra Lopez, A; Ndode-Ekane, XE; Pitkanen, A; Gröhn, O. 2018. Detection of Hyperexcitability by fMRI After Experimental Traumatic Brain Injury Journal of neurotrauma 35 22: 2708-2717. 2018
• Salo, Raimo A; Belevich, Ilya; Manninen, Eppu; Jokitalo, Eija; Gröhn, Olli; Sierra, Alejandra. 2018. Quantification of anisotropy and orientation in 3D electron microscopy and diffusion tensor imaging in injured rat brain. NEUROIMAGE 172: 404-414. 2018
• Rasch, Julian; Kolehmainen, Ville; Nivajärvi, Riikka; Kettunen, Mikko; Grohn, Olli; Burger, Martin; Brinkmann, Eva-Maria. 2018. Dynamic MRI reconstruction from undersampled data with an anatomical prescan INVERSE PROBLEMS 34 7: 074001. 2018
• Paasonen, Jaakko; Stenroos, Petteri; Salo, Raimo A; Kiviniemi, Vesa; Gröhn Olli. 2018. Functional connectivity under six anesthesia protocols and the awake condition in rat brain. NEUROIMAGE 172: 9-20. 2018
• Lehto, Lauri J; Filip, Pavel; Laakso, Hanne; Sierra, Alejandra; Slopsema, Julia P; Johnson, Matthew D; Eberly, Lynn E; Low, Walter C; Gröhn, Olli; Tanila, Heikki; Mangia, Silvia; Michael, Shalom. 2018. Tuning Neuromodulation Effects by Orientation Selective Deep Brain Stimulation in the Rat Medial Frontal Cortex Frontiers in Neuroscience 12: 899. 2018
• Immonen, Riikka; Harris, Neil G; Wright, David; Johnston, Leigh; Manninen, Eppu; Smith, Gregory; Paydar, Afshin; Branch, Craig; Grohn Olli. 2018. Imaging biomarkers of epileptogenecity after traumatic brain injury - Preclinical frontiers Neurobiology of disease 2019; 123: 75-85. 2018
• Wettenhovi Ville-Veikko, Kolehmainen Ville, Huttunen Joanna, Kettunen Mikko, Gröhn Olli, Vauhkonen Marko. 2017. State Estimation with Structural Priors in fMRI. Journal of Mathematical Imaging and Vision 2018; 60 2: 174-188. 2017
• Lehto LJ, Sierra A, Gröhn O. 2017. Magnetization transfer SWIFT MRI consistently detects histologically verified myelin loss in the thalamocortical pathway after a traumatic brain injury in rat. NMR IN BIOMEDICINE 30 2: e3678. 2017
• Salo RA, Miettinen T, Laitinen T, Gröhn O, Sierra A. 2017. Diffusion tensor MRI shows progressive changes in the hippocampus and dentate gyrus after status epilepticus in rat - histological validation with Fourier-based analysis. NEUROIMAGE 152: 221-236. 2017
• Paasonen J, Salo RA, Ihalainen J, Leikas JV, Savolainen K, Lehtonen M, Forsberg MM, Gröhn O. 2017. Dose-response effect of acute phencyclidine on functional connectivity and dopamine levels, and their association with schizophrenia-like symptom classes in rat. NEUROPHARMACOLOGY 119: 15-25. 2017
• Norton Terence JT, Pereyra Marcelo, Knight Michael J, McGarry Bryony M, Jokivarsi Kimmo T, Grohn Olli HJ, Kauppinen Risto A. 2017. Stroke onset time determination using MRI relaxation times without non-ischaemic reference in a rat stroke model. Biomedical Spectroscopy and Imaging 6 1-2: 25-35. 2017
• McGarry BL, Jokivarsi KT, Knight MJ, Grohn OHJ, Kauppinen RA. 2017. A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia. Journal of visualized experiments 127: 1-6. 2017
• Bertoglio Daniele, Verhaeghe Jeroen, Dedeurwaerdere Stefanie, Gröhn Olli. 2017. Neuroimaging in animal models of epilepsy. NEUROSCIENCE 358: 277-299. 2017
• Lehto Lauri J, Slopsema Julia P, Johnson Matthew D, Shatillo Artem, Teplitzky Benjamin A, Utecht Lynn, Adriany Gregor, Mangia Silvia, Sierra Alejandra, Low Walter C, Gröhn Olli, Michaeli Shalom. 2017. Orientation selective deep brain stimulation. Journal of Neural Engineering 14 1: 016016. 2017
• Lehto Lauri J, Albors Aloma A. Sierra Alejandra, Tolppanen Laura, Eberly Lynn E, Mangia Silvia, Nurmi Antti, Michaeli Shalom, Gröhn Olli. 2017. Lysophosphatidyl Choline Induced Demyelination in Rat Probed by Relaxation along a Fictitious Field in High Rank Rotating Frame. Frontiers in Neuroscience 11: 433. 2017
• Johnson G, Lehto L, Mangia S, Gröhn O, Michaeli S, Kodandaramaiah S. 2017. Conceptual Design of Flex-DBS, a Mechanically Reconfigurable Deep Brain Stimulation Probe. In: - (ed.) , Proceedings of the 2017 Design of Medical Devices Conference. American society of mechanical engineers. s. V001T02A001. 2017
• Gröhn Olli, Sierra Alejandra. 2017. Searching for epilepsy's crystal ball. Elife 6: e29853. 2017
• Gröhn O, Deleye S, Bertoglio D, Dedeurwaerdere S. 2017. In Vivo Imaging in Rodents. In: Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL (ed.) Models of Seizures and Epilepsy (Second Edition). Elsevier. s. 197-215. 2017
• Aggarwal M, Li X, Gröhn O, Sierra A. 2017. Nuclei-specific deposits of iron and calcium in the rat thalamus after status epilepticus revealed with quantitative susceptibility mapping (QSM). JOURNAL OF MAGNETIC RESONANCE IMAGING 2018; 47 2: 554-564. 2017
• Lehto Lauri J, Idiyatullin Djaudat, Zhang Jinjin, Utecht Lynn, Adriany Gregor, Garwood Michael, Gröhn Olli, Michaeli Shalom, Mangia Silvia. 2017. MB-SWIFT functional MRI during deep brain stimulation in rats. NEUROIMAGE 159: 443-448. 2017
• Pirttimäki T, Salo RA, Shatillo A, Kettunen MI, Paasonen J, Sierra A, Jokivarsi K, Leinonen V, Andrade P, Quittek S, Pitkänen A, Gröhn O. 2016. Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents. JOURNAL OF NEUROSCIENCE METHODS 274: 154-163. 2016
• Zhurakovskaya Ekaterina, Paasonen Jaakko, Shatillo Artem, Lipponen Arto, Salo Raimo, Aliev Raimo, Tanila Heikki, Gröhn Olli. 2016. Global Functional Connectivity Differences between Sleep-Like States in Urethane Anesthetized Rats Measured by fMRI. PLOS ONE 11 5: e0155343. 2016
• Vieites-Prado Alba, Iglesias-Rey Ramón, Fernández-Susavila Héctor, da Silva-Candal Andrés, Rodríguez-Castro Emilio, Gröhn Olli HJ, Wellmann Sven, Sobrino Tomás, Castillo José, Campos Francisco. 2016. Protective Effects and Magnetic Resonance Imaging Temperature Mapping of Systemic and Focal Hypothermia in Cerebral Ischemia. STROKE 47 9: 2386-2396. 2016
• Rautiainen J, Nieminen MT, Salo EN, Kokkonen HT, Mangia S, Michaeli S, Gröhn O, Jurvelin JS, Töyräs J, Nissi MJ. 2016. Effect of collagen cross-linking on quantitative MRI parameters of articular cartilage. OSTEOARTHRITIS AND CARTILAGE 24 9: 1656-1664. 2016
• Pitkänen A, Löscher W, Vezzani A, Becker AJ, Simonato M, Lukasiuk K, Gröhn O, Bankstahl JP, Friedman A, Aronica E, Gorter JA, Ravizza T, Sisodiya SM, Kokaia M, Beck H. 2016. Advances in the development of biomarkers for epilepsy. LANCET NEUROLOGY 15 8: 843-856. 2016
• Nissinen Tuomo, Näkki Simo, Laakso Hanne, Kuciauskas Dalius, Kaupinis Algirdas, Kettunen Mikko I, Liimatainen Timo, Hyvönen Mervi, Valius Mindaugas, Gröhn Olli, Lehto Vesa-Pekka. 2016. Tailored Dual PEGylation of Inorganic Porous Nanocarriers for Extremely Long Blood Circulation in Vivo. ACS Applied Materials & Interfaces 8 48: 32723-32731. 2016
• Paasonen Jaakko, Salo Raimo A, Shatillo Artem, Forsberg Markus M, Närväinen Johanna, Huttunen Joanna K, Gröhn Olli. 2016. Comparison of seven different anesthesia protocols for nicotine pharmacologic magnetic resonance imaging in rat. EUROPEAN NEUROPSYCHOPHARMACOLOGY 26 3: 518-531. 2016
• Paasonen Jaakko, Salo Raimo A, Huttunen Joanna K, Gröhn Olli. 2016. Resting-state functional MRI as a tool for evaluating brain hemodynamic responsiveness to external stimuli in rats. MAGNETIC RESONANCE IN MEDICINE 78 3: 1136-1146. 2016
• McGarry BL, Rogers HJ, Knight MJ, Jokivarsi KT, Sierra A, Gröhn OHJ, Kauppinen RA. 2016. Stroke onset time estimation from multispectral quantitative magnetic resonance imaging in a rat model of focal permanent cerebral ischemia. INTERNATIONAL JOURNAL OF STROKE 11 6: 677-82. 2016
• McGarry BL, Rogers HJ, Knight MJ, Jokivarsi KT, Gröhn OHJ, Kauppinen RA. 2016. Determining stroke onset time using quantitative MRI: High accuracy, sensitivity and specificity obtained from magnetic resonance relaxation times. Cerebrovascular Diseases Extra 6: 60-65. 2016
• Lapinlampi N, Melin E, Aronica E, Bankstahl JP, Becker A, Bernard C, Gorter JA, Gröhn O, Lipsanen A, Lukasiuk K, Löscher W, Paananen J, Ravizza T, Roncon P, Simonato M, Vezzani A, Kokaia M, Pitkänen A. 2016. Common data elements and data management: Remedy to cure underpowered preclinical studies. EPILEPSY RESEARCH 129 January 2017: 87-90. 2016
• Knight MJ, Mcgarry BL, Rogers HJ, Jokivarsi KT, Gröhn OHJ, Kauppinen RA. 2016. A spatiotemporal theory for MRI T2 relaxation time and apparent diffusion coefficient in the brain during acute ischaemia: application and validation in a rat acute stroke model. Journal of Cerebral Blood Flow & Metabolism 36 7: 1232-1243. 2016
• Levijoki Jouko, Kivikko Matti, Pollesello Piero, Sallinen Jukka, Hyttilä-Hopponen Minja, Kuoppamäki Mikko, Haasio Kristiina, Gröhn Olli, Miettinen Riitta, Puoliväli Jukka, Tähtivaara Leena, Yrjänheikki Juha, Haapalinna Antti. 2015. Levosimendan alone and in combination with valsartan prevents stroke in Dahl salt-sensitive rats. EUROPEAN JOURNAL OF PHARMACOLOGY 750: 132-140. 2015
• Sierra A, Gröhn O, Pitkänen A. 2015. Imaging microstructural damage and plasticity in the hippocampus during epileptogenesis. NEUROSCIENCE 309: 162-172. 2015
• Shatillo Artem, Salo Raimo A, Giniatullin Rashid, Gröhn Olli H. 2015. Involvement of NMDA receptor subtypes in cortical spreading depression in rats assessed by fMRI. NEUROPHARMACOLOGY 93: 164-170. 2015
• Heidi Marjonen, Alejandra Sierra, Anna Nyman, Vladimir Rogojin, Olli Gröhn, Anni-Maija Linden, Sampsa Hautaniemi, Nina Kaminen-Ahola. 2015. Early maternal alcohol consumption alters hippocampal DNA methylation, gene expression and volume in a mouse model. PLOS ONE [ONLINE] 10 5: e0124931. 2015
• Lehto Lauri Juhani, Garwood Michael, Grohn Olli, Corum Curtis Andrew. 2015. Phase imaging in brain using SWIFT. JOURNAL OF MAGNETIC RESONANCE (SAN DIEGO) 252: 20-28. 2015
• Laitinen Teemu, Sierra Alejandra, Bolkvadze Tamuna, Pitkänen Asla, Gröhn Olli. 2015. Diffusion tensor imaging detects chronic microstructural changes in white and gray matter after traumatic brain injury in rat. Frontiers in Neuroscience 9 Article 128: 12 p. 2015
• Kärkkäinen Elisa, Lahtinen Hanna-Maija, Närväinen Johanna, Gröhn Olli, Tanila Heikki. 2015. Brain amyloidosis and BDNF deficiency have opposite effects on brain volumes in AßPP/PS1 mice both in vivo and ex vivo. Journal of Alzheimer's Disease 46 4: 926-946. 2015
• Hakkarainen Hanne, Sierra Alejandra, Mangia Silvia, Garwood Michael, Michaeli Shalom, Gröhn Olli, Liimatainen Timo. 2015. MRI relaxation in the presence of fictitious fields correlates with myelin content in normal rat brain. MAGNETIC RESONANCE IN MEDICINE first published online: 3 FEB 2015: 8 p. 2015
• Teplov Victor, Shatillo Artem, Nippolainen Ervin, Gröhn Olli, Giniatullin Rashid, Kamshilin Alexei A. 2014. Fast vascular component of cortical spreading depression revealed in rats by blood pulsation imaging. Journal of Biomedical Optics 19 4: 046011-1-9. 2014
• Rogers Harriet J, McGarry Bryony L, Knight Michael J, Jokivarsi Kimmo T, Gröhn Olli H, Kauppinen Risto A. 2014. Timing the ischaemic stroke by 1H-MRI: improved accuracy using absolute relaxation times over signal intensities. NEUROREPORT 2014 Oct 22;25(15): 1180-1185. 2014
• Pryazhnikov E, Kislin M, Tibeykina M, Toptunov D, Ptukha A, Shatillo A, Gröhn O, Giniatullin R, Khiroug L. 2014. Opposite reactivity of meningeal versus cortical microvessels to the nitric oxide donor glyceryl trinitrate evaluated in vivo with two-photon imaging. PLOS ONE [ONLINE] 2014 Feb 28;9(2):e89699: e89699. 2014
• Pitkänen Asla, Kemppainen Samuli, Ndode-Ekane Xavier Ekolle, Huusko Noora, Huttunen Joanna K, Gröhn Olli, Immonen Riikka, Sierra Alejandra, Bolkvadze Tamuna. 2014. Posttraumatic epilepsy - Disease or comorbidity?. EPILEPSY & BEHAVIOR 2014 Feb 11. [Epub ahead of print]: --. 2014
• Pitkänen A, Immonen R, Ndode-Ekane X, Gröhn O, Stöhr T, Nissinen J. 2014. Effect of lacosamide on structural damage and functional recovery after traumatic brain injury in rats. EPILEPSY RESEARCH 2014 May;108(4): 653-65. 2014
• Nissinen Tuomo, Näkki Simo, Latikka Mika, Heinonen Markku, Liimatainen Timo, Xu Wujun, Ras Robin HA, Gröhn Olli, Riikonen Joakim, Lehto Vesa-Pekka. 2014. Facile synthesis of biocompatible superparamagnetic mesoporous nanoparticles for imageable drug delivery. Microporous and Mesoporous Materials 195: 2-8. 2014
• Nissi Mikko J, Lehto Lauri J, Corum Curtis A, Idiyatullin Djaudat, Ellermann Jutta M, Gröhn Olli HJ, Nieminen Miika T. 2014. Measurement of T1 relaxation time of osteochondral specimens using VFA-SWIFT. MAGNETIC RESONANCE IN MEDICINE - -: -. 2014
• Mishra Asht Mangal, Bai Xiaoxiao, Sanganahalli Basavaraju G, Waxman Stephen G, Shatillo Olena, Gröhn Olli, Hyder Fahmeed, Pitkänen Asla, Blumenfeld Hal. 2014. Decreased resting functional connectivity after traumatic brain injury in the rat. PLOS ONE [ONLINE] 2014 Apr 18;9(4): e95280. 2014
• Manninen O, Laitinen T, Lehtimäki KK, Tegelberg S, Lehesjoki AE, Gröhn O, Kopra O. 2014. Progressive volume loss and white matter degeneration in cstb-deficient mice: a diffusion tensor and longitudinal volumetry MRI study. PLOS ONE [ONLINE] 2014 Mar 6;9(3):e90709.: e90709. 2014
• Korpisalo P, Hytönen JP, Laitinen JT, Närväinen J, Rissanen TT, Gröhn OH, Ylä-Herttuala S. 2014. Ultrasound imaging with bolus delivered contrast agent for the detection of angiogenesis and blood flow irregularities. AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY 307 8: H1226-H1232. 2014
• Autio JA, Shatillo A, Giniatullin R, Gröhn OH. 2014. Parenchymal spin-lock fMRI signals associated with cortical spreading depression. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 34 5: 768-775. 2014
• Sierra A, Laitinen T, Gröhn O, Pitkänen A. 2013. Diffusion tensor imaging of hippocampal network plasticity. Brain structure & function 220 2: 781-801. 2013
• Shatillo A, Koroleva K, Giniatullina R, Naumenko N, Slastnikova AA, Aliev RR, Bart G, Atalay M, Gu C, Khazipov R, Davletov B, Grohn O, Giniatullin R. 2013. Cortical spreading depression induces oxidative stress in the trigeminal nociceptive system. NEUROSCIENCE 2013 Sep 11;253C: 341-349. 2013
• Niskanen JP, Airaksinen AM, Sierra A, Huttunen JK, Nissinen J, Karjalainen PA, Pitkänen A, Gröhn OH. 2013. Monitoring functional impairment and recovery after traumatic brain injury in rats by FMRI. JOURNAL OF NEUROTRAUMA (NEW YORK NY) 2013 Apr 1;30(7): 546-56. 2013
• Manninen O, Koskenkorva P, Lehtimäki KK, Hyppönen J, Könönen M, Laitinen T, Kalimo H, Kopra O, Kälviäinen R, Gröhn O, Lehesjoki AE, Vanninen R. 2013. White Matter Degeneration with Unverricht-Lundborg Progressive Myoclonus Epilepsy: A Translational Diffusion-Tensor Imaging Study in Patients and Cystatin B-Deficient Mice. RADIOLOGY 2013 Jun 20. [Epub ahead of print]: --. 2013
• Jokivarsi KT, Liimatainen T, Kauppinen RA, Gröhn OH, Närväinen J. 2013. Relaxation Along a Fictitious Field (RAFF) and Z-spectroscopy using Alternating-Phase Irradiation (ZAPI) in Permanent Focal Cerebral Ischemia in Rat. PLOS ONE [ONLINE] 2013 Jul 17;8(7):e69157: --. 2013
• Immonen R, Kharatishvili I, Gröhn O, Pitkänen A. 2013. MRI biomarkers for post-traumatic epileptogenesis.. JOURNAL OF NEUROTRAUMA (NEW YORK NY) 2013 Jul 15;30(14): 1305-9. 2013
• Hemminki O, Immonen R, Närväinen J, Kipar A, Paasonen J, Jokivarsi KT, Yli-Ollila H, Soininen P, Partanen K, Joensuu T, Parvianen S, Pesonen SK, Koski A, Vähä-Koskela M, Cerullo V, Pesonen S, Gröhn OH, Hemminki A. 2013. In vivo magnetic resonance imaging and spectroscopy identifies oncolytic adenovirus responders. INTERNATIONAL JOURNAL OF CANCER 6 DEC 2013 [Epub ahead of print]: --. 2013
• Torvinen S, Silvennoinen M, Piitulainen H, Närväinen J, Tuunanen P, Gröhn O, Koch LG, Britton SL, Kainulainen H. 2012. Rats bred for low aerobic capacity become promptly fatigued and have slow metabolic recovery after stimulated, maximal muscle contractions. PLOS ONE [ONLINE] 2012;7(11):e48345: --. 2012
• Tukiainen T, Jylänki P, Mäkinen VP, Gröhn O, Hallikainen M, Soininen H, Kivipelto M, Kaski K, Groop PH, Savolainen MJ, Pirttilä T, Soininen P, Ala-Korpela M. 2012. Mild cognitive impairment associates with concurrent decreases in serum cholesterol and cholesterol-related lipoprotein subclasses JOURNAL OF NUTRITION, HEALTH & AGING 16 7: 631-635. 2012
• Airaksinen AM, Hekmatyar SK, Jerome N, Niskanen JP, Huttunen JK, Pitkänen A, Kauppinen RA, Gröhn OH. 2012. Simultaneous BOLD fMRI and local field potential measurements during kainic acid-induced seizures. EPILEPSIA (NY) 2012 Jul;53(7): 1245-53. 2012
• Musthafa HS, Dragneva G, Lottonen L, Merentie M, Petrov L, Heikura T, Ylä-Herttuala E, Ylä-Herttuala S, Gröhn O, Liimatainen T. 2012. Longitudinal rotating frame relaxation time measurements in infarcted mouse myocardium in vivo. MAGNETIC RESONANCE IN MEDICINE 2012 Jun 26 [Epub ahead of print]: --. 2012
• Lehto LJ, Sierra A, Corum CA, Zhang J, Idiyatullin D, Pitkänen A, Garwood M, Gröhn O. 2012. Detection of Calcifications In Vivo and Ex Vivo after Brain Injury in Rat Using SWIFT. NEUROIMAGE 2012 Jul 16;61(4): 761-72. 2012
• Gröhn O, Sierra A, Immonen R, Laitinen T, Lehtimäki K, Airaksinen A, Hayward N, Nairismagi J, Lehto L, Pitkänen A. 2011. Multimodal MRI assessment of damage and plasticity caused by status epilepticus in the rat brain EPILEPSIA (NY) 52(Suppl. 8): 57-60. 2011
• Hayward Nick Mark Edward Alexander, Tuunanen Pasi, Immonen Riikka, Ndode-Ekane Xavier Ekolle, Pitkänen Asla, Gröhn Olli. 2011. Magnetic resonance imaging of regional hemodynamic and cerebrovascular recovery after lateral fluid-percussion brain injury in rats. Journal of Cerebral Blood Flow & Metabolism 31: 166-177. 2011
• Huttunen Joanna K, Niskanen Juha-Pekka, Lehto Lauri J, Airaksinen Antti M, Niskanen Eini I, Penttonen Markku, Gröhn Olli. 2011. Evoked local field potentials can explain temporal variation in blood oxygenation level-dependent responses in rat somatosensory cortex. NMR IN BIOMEDICINE 24: 209-215. 2011
• Kuronen M, Hermansson M, Manninen O, Zech I, Talvitie M, Laitinen T, Gröhn O, Somerharju P, Eckhardt M, Cooper JD, Lehesjoki AE, Lahtinen U, Kopra O. 2011. Galactolipid deficiency in the early pathogenesis of neuronal ceroid lipofuscinosis model Cln8(mnd) : implications to delayed myelination and oligodendrocyte maturation NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 2012 Aug;38(5) 2011 Nov 2 [Epub ahead of print]: 471-86. 2011
• Liimatainen T, Sierra A, Hanson T, Sorce DJ, Ylä-Herttuala S, Garwood M, Michaeli S, Gröhn O. 2011. Glioma cell density in a rat gene therapy model gauged by water relaxation rate along a fictitious magnetic field. Magn. Reson. Med. 67; 269-277, 2012 MAGNETIC RESONANCE IN MEDICINE 2012 Jan;67(1) Epub 2011 Jun 30: 269-277. 2011
• Sallinen H, Anttila M, Gröhn O, Koponen J, Hämäläinen K, Kholova I, Heikura T, Kosma VM, Heinonen S, Alitalo K, Ylä-Herttuala S. 2011. VEGFR-1 and -3 and angiopoietin receptor Tie2 targeted gene therapy prevents the growth of solid human ovarian cancer in mice compared to cotargeting Tie1 and Tie2. CANCER GENE THERAPY 18 2: 100-9. 2011
• Sierra Alejandra, Laitinen Teemu, Lehtimäki Kimmo, Rieppo Lassi, Pitkänen Asla, Gröhn Olli. 2011. Diffusion tensor MRI with tract-based spatial statistics and histology reveals undiscovered lesioned areas in kainate model of epilepsy in rat. Brain Structure and Function 216: 123-135. 2011
• Hayward Nick MEA, Yanev Pavel, Haapasalo Annakaisa, Miettinen Riitta, Hiltunen Mikko, Gröhn Olli, Jolkkonen Jukka. 2011. Chronic hyperperfusion and angiogenesis follow subacute hypoperfusion in the thalamus of rats with focal cerebral ischemia. Journal of Cerebral Blood Flow & Metabolism 31: 1119-1132. 2011
• Jokivarsi KT, Hiltunen Y, Tuunanen PI, Kauppinen RA & Gröhn OH. 2010. Correlating tissue outcome with quantitative multiparametric MRI of acute cerebral ischemia in rats. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 30: 415-427. 2010
• Sallinen H, Anttila M, Gröhn O, Koponen J, Hämäläinen K, Kholova I, Kosma VM, Heinonen S, Alitalo K & Ylä-Herttuala S. 2010. Cotargeting of VEGFR-1 and -3 and angiopoietin receptor Tie2 reduces the growth of solid human ovarian cancer in mice. CANCER GENE THERAPY 18 2: 100-109. 2010
• Prantner V, Isaksson H, Närväinen J, Lammentausta E, Nissi MJ, Avela J, Gröhn OH, Jurvelin JS. 2010. NMR relaxation times of trabecular bone - reproducibility, relationships to tissue structure and effects of sample freezing. PHYSICS IN MEDICINE AND BIOLOGY 55(2010): 1-13. 2010
• Ndode-Ekane XE, Hayward N, Gröhn O & Pitkänen A. 2010. Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy. NEUROSCIENCE 166: 312-332. 2010
• Jokivarsi KT, Hiltunen Y, Gröhn H, Tuunanen P, Gröhn OH & Kauppinen RA. 2010. Estimation of the onset time of cerebral ischemia using T1rho and T2 MRI in rats. STROKE 41: 2335-2340. 2010
• Airaksinen AM, Niskanen JP, Chamberlain R, Huttunen JK, Nissinen J, Garwood M, Pitkänen A & Gröhn O. 2010. Simultaneous fMRI and local field potential measurements during epileptic seizures in medetomidine-sedated rats using raser pulse sequence MAGNETIC RESONANCE IN MEDICINE 64: 1191-1199. 2010
• Immonen R, Heikkinen T, Tähtivaara L, Nurmi A, Stenius TK, Puoliväli J, Tuinstra T, Phinney AL, Van Vliet B, Yrjänheikki J et al. 2010. Cerebral blood volume alterations in the perilesional areas in the rat brain after traumatic brain injury¿comparison with behavioral outcome Journal of Cerebral Blood Flow & Metabolism 30: 1318 -1328. 2010
• Laitinen T, Sierra A, Pitkänen A & Gröhn O. 2010. Diffusion tensor MRI of axonal plasticity in the rat hippocampus. NEUROIMAGE 51: 251-530. 2010
• Hayward NM, Ndode-Ekane XE, Kutchiashvili N, Gröhn O Pitkänen A.. 2010. Elevated cerebral blood flow and vascular density in the amygdala after status epilepticus in rats. NEUROSCIENCE LETTERS 484: 39-42. 2010
• Hayward NM, Immonen R, Tuunanen PI, Ndode-Ekane XE, Gröhn O & Pitkänen A. 2010. Association of chronic vascular changes with functional outcome after traumatic brain injury in rats JOURNAL OF NEUROTRAUMA (NEW YORK NY) 27: 2203-2219. 2010
• Immonen RJ, Kharatishvili I, Gröhn H, Pitkänen A, Gröhn OHJ. 2009. Quantitative MRI predicts long-term structural and functional outcome after experimental traumatic brain injury NEUROIMAGE 45: 1-9. 2009
• Immonen RJ, Kharatishvili I, Niskanen J-P, Gröhn H, Pitkänen A, Gröhn OHJ. 2009. Distinct MRI pattern in lesional and perilesional area after traumatic brain injury in rat - 11 months follow-up. EXPERIMENTAL NEUROLOGY 215: 29-40. 2009
• Jokivarsi KT, Niskanen J-P, Michaeli S, Gröhn HI, Garwood M, Kauppinen RA, Gröhn OH. 2009. Quantitative assessment of water pools by T1rho and T2rho MRI in acute cerebral ischemia of the rat. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 29: 206-216. 2009
• Kaikkonen MU, Lesch HP, Pikkarainen J, Räty JK, Vuorio T, Huhtala T, Taavitsainen M, Laitinen T, Tuunanen P, Gröhn O, Närvänen A, Airenne KJ, Ylä-Herttuala S. 2009. (Strept)avidin-displaying lentiviruses as versatile tools for targeting and dual imaging of gene delivery. GENE THERAPY 16: 894-904. 2009
• Kharatishvili I, Sierra A, Immonen RJ, Gröhn OHJ, Pitkänen A. 2009. Quantitative T2 mapping as a potential marker for the initial assessment of the severity of damage after traumatic brain injury in rat. EXPERIMENTAL NEUROLOGY 217: 154-164. 2009
• Pitkänen A, Immonen RJ, Gröhn OH, Kharatishvili I. 2009. From traumatic brain injury to posttraumatic epilepsy: what animal models tell us about the process and treatment options. EPILEPSIA. SUPPLEMENT 50 2: 21-29. 2009
• Parry-Jones AR, Liimatainen T, Kauppinen RA, Gröhn OH, Rothwell NJ. 2008. Interleukin-1 exacerbates focal cerebral ischemia and reduces ischemic brain temperature in the rat. MAGNETIC RESONANCE IN MEDICINE 59: 1239-1249. 2008
• Tukiainen T, Tynkkynen T, Mäkinen V-P, Jylänki P, Kangas A, Hokkanen J, Vehtari A, Gröhn O, Hallikainen M, Soininen H, Kivipelto M, Groop P-H, Kaski K, Laatikainen R, Soininen P, Pirttilä T, Ala-Korpela M, Soininen H, Pirttilä. 2008. A multi-metabolite analysis of serum by 1H NMR spectroscopy: Early systemic signs of Alzheimer's disease. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 375: 356-361. 2008
• Sierra A, Michaeli S, Niskanen J-P, Valonen PK, Gröhn HI, Ylä-Herttuala S, Garwood M, Gröhn OH. 2008. Water spin dynamics during apoptotic cell death in glioma gene therapy probed by T1rho and T2rho. MAGNETIC RESONANCE IN MEDICINE 59: 1311-1319. 2008
• Rissanen TT, Korpisalo P, Karvinen H, Liimatainen T, Laidinen S, Gröhn OH, Ylä-Herttuala S. 2008. High-resolution ultrasound perfusion imaging of therapeutic angiogenesis. JACC: CARDIOVASCULAR IMAGING 1 1: 83 - 91. 2008
• Korpisalo P, Rissanen TT, Bengtsson T, Liimatainen T, Laidinen S, Karvinen H, Markkanen JE, Gröhn OH, Ylä-Herttuala S. 2008. Therapeutic angiogenesis with placental growth factor improves exercise tolerance of ischaemic rabbit hindlimbs. CARDIOVASCULAR RESEARCH 80 2: 263-270. 2008
• Liimatainen TJ, Erkkilä AT, Valonen P, Vidgren H, Lakso M, Wong G, Gröhn OHJ, Ylä-Herttuala S, Hakumäki JM. 2008. 1H MR spectroscopic imaging of phospholipase-mediated membrane lipid release in apoptotic rat glioma in vivo. MAGNETIC RESONANCE IN MEDICINE 59: 1232-1238. 2008
• Lammentausta E, Silvast TS, Närväinen J, Jurvelin JS, Nieminen MT, Gröhn OHJ. 2008. T2, Carr-Purcell T2 and T1rho of fat and water as surrogate markers of trabecular bone structure. PHYSICS IN MEDICINE AND BIOLOGY 53: 543-555. 2008
• Immonen RJ, Kharatishvili I, Sierra A, Einula C, Pitkänen A, Gröhn OH. 2008. Manganese enhanced MRI detects mossy fiber sprouting rather than neurodegeneration, gliosis or seizure-activity in the epileptic rat hippocampus NEUROIMAGE 40: 1718-1730. 2008
• Huttunen JK, Gröhn O, Penttonen M. 2008. Coupling between simultaneously recorded BOLD response and neuronal activity in the rat somatosensory cortex. NEUROIMAGE 39 2: 775-785. 2008
• Kholová I, Koota S, Kaskenpää N, Leppänen P, Närväinen J, Kavec M, Rissanen TT, Hazes T, Korpisalo P, Gröhn O, Ylä-Herttuala S. 2007. Adenovirus-mediated gene transfer of human vascular endothelial growth factor-d induces transient angiogenic effects in mouse hind limb muscle. HUMAN GENE THERAPY 18: 232-244. 2007
• Valette J, Park J-Y, Gröhn O, Ugurbil K, Garwood M, Henry P-G. 2007. Spectroscopic imaging with volume selection by unpaired adiabatic pi pulses: Theory and application JOURNAL OF MAGNETIC RESONANCE (SAN DIEGO) 189 1: 1-12. 2007
• Räty JK, Liimatainen T, Kaikkonen MU, Gröhn O, Airenne KJ, Ylä-Herttuala S. 2007. Non-invasive imaging in gene therapy. MOLECULAR THERAPY 15 9: 1579-1586. 2007
• Pitkänen A, Kharatisvili I, Karhunen H, Lukasiuk K, Immonen R, Nairismägi J, Gröhn O, Nissinen J. 2007. Epileptogenesis in experimental models. EPILEPSIA. SUPPLEMENT 48 2: 13-20. 2007
• Kharatishvili I, Immonen R, Gröhn O, Pitkänen A. 2007. Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis. BRAIN 130 12: 3155-3168. 2007
• Kettunen MI, Sierra A, Närväinen MJ, Valonen PK, Ylä-Herttuala S, Kauppinen RA, Gröhn OHJ. 2007. Low spin-lock field T1 relaxation in the rotating frame as a sensitive MR imaging marker for gene therapy treatment response in rat glioma. RADIOLOGY 243: 796-803. 2007
• Jolkkonen J, Jokivarsi K, Laitinen T, Gröhn O. 2007. Subacute hemorrhage and resolution of edema in Rose Bengal stroke model in rats coincides with improved sensorimotor functions. NEUROSCIENCE LETTERS 428 2-3: 99-102. 2007
• Jokivarsi KT, Gröhn HI, Gröhn OH, Kauppinen RA. 2007. Proton transfer ratio, lactate, and intracellular pH in acute cerebral ischemia. MAGNETIC RESONANCE IN MEDICINE 57 4: 647-653. 2007
• Gröhn O, Pitkänen A. 2007. Magnetic resonance imaging in animal models of epilepsy-noninvasive detection of structural alterations. EPILEPSIA. SUPPLEMENT 48 4: 3-10. 2007
• Liimatainen T, Hakumäki J, Tkác I, Gröhn O. 2006. Ultra-short echo time spectroscopic imaging in rats: implications for monitoring lipids in glioma gene therapy. NMR IN BIOMEDICINE 19 5: 554-559. 2006
• Nairismägi J, Pitkänen A, Narkilahti S, Huttunen J, Kauppinen RA, Gröhn OHJ. 2006. Manganese-enhanced magnetic resonance imaging of mossy fiber plasticity in vivo. NEUROIMAGE 30 1: 130-135. 2006
• Nurmi A, Goldsteins G, Närväinen J, Pihlaja R, Ahtoniemi T, Gröhn O, Koistinaho J. 2006. Antioxidant pyrrolidine dithiocarbamate activates Akt-GSK signaling and is neuroprotective in neonatal hypoxia¿ischemia. FREE RADICAL BIOLOGY & MEDICINE 40 10: 1776-1784. 2006
• Valonen PK, Griffin JL, Lehtimäki KK, Liimatainen T, Nicholson JK, Gröhn OHJ, Kauppinen RA. 2005. High-resolution magic-angle-spinning 1H NMR spectroscopy reveals different responses in choline-containing metabolites upon gene therapy-induced programmed cell death in rat brain glioma. NMR IN BIOMEDICINE 18 4: 252-259. 2005
• Rissanen TT, Korpisalo P, Markkanen JE, Liimatainen T, Ordén M-R, Kholová I, de Goede A, Heikura T, Gröhn OH, Ylä-Herttuala S. 2005. Blood flow remodels growing vasculature during vascular endothelial growth factor gene therapy and determines between capillary arterialization and sprouting angiogenesis CIRCULATION 112: 3937-3946. 2005
• Pitkänen A, Gröhn O. 2005. Experimental febrile seizures require an undetermined factor for induction of hippocampal sclerosis in immature rat brain. EPILEPSY CURRENTS 53 3: 98-100. 2005
• Michaeli S, Gröhn H, Gröhn O, Sorce DJ, Kauppinen R, Springer CS Jr, Ugurbil K, Garwood M. 2005. Exchange-influenced T2rho contrast in human brain images measured with adiabatic radio frequency pulses. MAGNETIC RESONANCE IN MEDICINE 53 4: 823-829. 2005
• Kettunen MI, Kauppinen RA, Gröhn OHJ. 2005. Dispersion of cerebral on-resonance T1 in the rotating frame (T1 rho) in global ischaemia. APPLIED MAGNETIC RESONANCE 29: 89-106. 2005
• Kettunen MI, Gröhn OHJ. 2005. Tumour gene therapy monitoring using magnetic resonance imaging and spectroscopy. CURRENT GENE THERAPY 5: 685-696. 2005
• Kavec M, Gröhn OHJ, Gröhn HI, Garwood M, Kauppinen RA. 2005. Dynamic dephasing changes in developing ischemic cerebral infarction in rats studied by Carr-Purcell T2 magnetic resonance imaging. MAGNETIC RESONANCE IN MEDICINE 53 4: 960-964. 2005
• Gröhn HI, Michaeli S, Garwood M, Kauppinen RA, Gröhn OHJ. 2005. Quantitative T(1rho) and adiabatic Carr-Purcell T2 magnetic resonance imaging of human occipital lobe at 4 T. MAGNETIC RESONANCE IN MEDICINE 54 1: 14-19. 2005
• Jack CR Jr, Garwood M, Wengenack TM, Borowski B, Curran GL, Lin J, Adriany G, Gröhn OHJ, Grimm R, Poduslo JF. 2004. In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent. MAGNETIC RESONANCE IN MEDICINE 52 6: 1263-1271. 2004
• Kavec M, Gröhn OHJ, Kettunen MI, Silvennoinen MJ, Garwood M, Kauppinen RA. 2004. Acute cerebral ischemia in rats studied by Carr-Purcell spin-echo magnetic resonance imaging: Assessment of blood oxygenation level-dependent and tissue effects on the transverse relaxation. MAGNETIC RESONANCE IN MEDICINE 51 6: 1138-1146. 2004
• Kettunen MI, Gröhn OHJ, Kauppinen RA. 2004. Quantitative T1rho NMR spectroscopy of rat cerebral metabolites in vivo: Effects of global ischemia. MAGNETIC RESONANCE IN MEDICINE 51 5: 875-880. 2004
• Mäkelä HI, De Vita E, Gröhn OHJ, Kettunen MI, Kavec M, Lythgoe M, Garwood M, Ordidge R, Kauppinen RA. 2004. B0 dependence of the on-resonance longitudinal relaxation time in the rotating frame (T1rho) in protein phantoms and rat brain in vivo. MAGNETIC RESONANCE IN MEDICINE 51 1: 4-8. 2004
• Nairismägi J, Gröhn OHJ, Kettunen MI, Nissinen J, Kauppinen RA, Pitkänen A. 2004. Progression of brain damage after status epilepticus and its association with epileptogenesis: a quantitative MRI study in a rat model of temporal lobe epilepy EPILEPSIA (NY) 45 9: 1024-1034. 2004
• Valonen PK, Lehtimäki KK, Väisänen TH, Kettunen MI, Gröhn OHJ, Ylä-Herttuala S, Kauppinen RA. 2004. Water diffusion in a rat glioma during ganciclovir-thymidine kinase gene therapy-induced programmed cell death in vivo: Correlation with cell density JOURNAL OF MAGNETIC RESONANCE IMAGING 19 4: 389-396. 2004
• Lehtimäki KK, Valonen PK, Griffin JL, Väisänen TH, Gröhn OHJ, Kettunen MI, Vepsäläinen J, Ylä-Herttuala S, Nicholson J, Kauppinen RA. 2003. Metabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro*. JOURNAL OF BIOLOGICAL CHEMISTRY 278 46: 45915-45923. 2003
• Kaasinen SK, Gröhn OHJ, Keinänen TA, Alhonen L, Jänne J. 2003. Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice. EXPERIMENTAL NEUROLOGY 183: 645-652. 2003
• Gröhn OHJ, Valonen PK, Lehtimäki KK, Väisänen TH, Kettunen MI, Ylä-Herttuala S, Kauppinen RA, Garwood M. 2003. Novel magnetic resonance imaging contrasts for monitoring response to gene therapy in rat glioma. CANCER RESEARCH 63: 7571-7574. 2003
• Griffin JL, Lehtimäki KK, Valonen PK, Gröhn OHJ, Kettunen MI, Ylä-Herttuala S, Pitkänen A, Nicholson JK, Kauppinen RA. 2003. Assignment of 1H nuclear magnetic resonance visible polyunsaturated fatty acids in BT4C gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death. CANCER RESEARCH 63: 3195-3201. 2003
• Gröhn OHJ, Mäkelä HI, Lukkarinen JA, DelaBarre L, Lin J, Garwood M, Kauppinen RA. 2003. On- and off-resonance T1rho MRI in acute cerebral ischemia of the rat. MAGNETIC RESONANCE IN MEDICINE 49 1: 172-176. 2003
• Hakumäki JM, Gröhn OHJ, Tyynelä K, Valonen P, Ylä-Herttuala S, Kauppinen RA. 2002. Early gene therapy - induced apoptotic response in BT4C gliomas by magnetic resonance relaxation contrast T1 in the rotating frame. CANCER GENE THERAPY 9: 338-345. 2002
• Kettunen MI, Gröhn OHJ, Silvennoinen MJ, Penttonen M, Kauppinen RA. 2002. Effects of intracellular pH, blood, and tissue oxygen tension on T-1rho relaxation in rat brain. MAGNETIC RESONANCE IN MEDICINE 48 3: 470-477. 2002
• Kettunen MI, Gröhn OHJ, Silvennoinen MJ, Penttonen M, Kauppinen RA. 2002. Quantitative assessment of the balance between oxygen delivery and consumption in the rat brain after transient ischemia with T2-BOLD magnetic resonance imaging. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 22 3: 262-270. 2002
• Kuhmonen J, Lukkarinen J, Gröhn O, Jolkkonen J, Sivenius J. 2002. Diazepam does not reduce infarct size in rats subjected to transient occlusion of the middle cerebral artery when normothermia is maintained JOURNAL OF PHARMACY AND PHARMACOLOGY 54: 1565-1569. 2002
• Mäkelä HI, Kettunen MI, Gröhn OHJ, Kauppinen RA. 2002. Quantitative T (1rho) and magnetization transfer magnetic resonance imaging of acute cerebral ischemia in the rat. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 22 5: 547-558. 2002
• Pitkänen A, Nissinen J, Nairismägi J, Lukasiuk K, Gröhn OHJ, Miettinen R, Kauppinen R. 2002. Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy: Sutula T, Pitkänen A, Do Seizures Damage the Brain.Elsevier. Progress in Brain Research. 67-83. 2002
• Gröhn OHJ, Kauppinen RA. 2001. Assessment of brain tissue viability in acute ischemic stroke by BOLD NMR. NMR IN BIOMEDICINE 14: 432-440. 2001
• Kavec M, Gröhn OHJ, Kettunen MI, Silvennoinen MJ, Penttonen M, Kauppinen RA. 2001. Use of spin echo T2 BOLD in assessment of cerebral misery perfusion at 1.5 T. MAGNETIC RESONANCE MATERIALS IN PHYSICS, BIOLOGY AND MEDICINE 12: 32-39. 2001
• Kettunen MI, Gröhn OHJ, Penttonen M, Kauppinen RA. 2001. Cerebral T1rho relaxation time increases immediately upon global ischemia in the rat independently of blood glucose and anoxic depolarization MAGNETIC RESONANCE IN MEDICINE 46: 565-572. 2001
• Mäkelä HI, Gröhn OHJ, Kettunen MI, Kauppinen RA. 2001. Proton exchange as a relaxation mechanism for T1 in the rotating frame in native and immobilized protein solutions. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 289: 813-818. 2001
• Kettunen MI, Gröhn OHJ, Lukkarinen JA, Vainio P, Silvennoinen MJ, Kauppinen RA. 2000. Interrelations of T1 and diffusion of water in acute cerebral ischemia of the rat MAGNETIC RESONANCE IN MEDICINE 44: 833-839. 2000
• Saarelainen T, Lukkarinen JA, Koponen S, Gröhn OHJ, Jolkkonen J, Koponen E, Haapasalo A, Alhonen L, Wong G, Koistinaho J, Kauppinen RA, Castrén E. 2000. Transgenic mice overexpressing truncated trkB neurotophin receptors in neurons show incresed susceptibility to cortical injury after focal cerebral inschemia MOLECULAR AND CELLULAR NEUROSCIENCE (SAN DIEGO CA) 16: 87-96. 2000
• Gröhn O. 2000. Magnetic Resonance Imaging of Acute Cerebral Ischaemia. Novel Haemodynamic and Parenchymal Indicators of Reversible and Irreversible Ischaemia. Kuopion yliopiston julkaisuja C. Luonnontieteet ja ympäristötieteet. 2000
• Gröhn OHJ, Kettunen MI, Penttonen M, Oja JME, van Zijl PCM, Kauppinen RA. 2000. Graded reduction of cerebral blood flow in rat as detected by the nuclear magnetic resonance relaxation time T2: a theoretical and experimental approach JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 20: 316-326. 2000
• Gröhn OHJ, Kettunen MI, Mäkelä HI, Penttonen M, Pitkänen A, Lukkarinen JA, Kauppinen RA. 2000. Early detection of irreversible cerebral ischemia in the rat using dispersion of the magnetic resonance imaging relaxation time, T1rho. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 20: 1457-1466. 2000
• Gröhn OHJ, Lukkarinen JA, Silvennoinen MJ, Pitkänen A, van Zijl PCM, Kauppinen RA. 1999. Quantitative magnetic resonance imaging assessment of cerebral ischemia in rat using on-resonance T1 in the rotating frame. MAGNETIC RESONANCE IN MEDICINE 42: 268-276. 1999
• Lukkarinen JA, Gröhn OHJ, Alhonen LI, Jänne J, Kauppinen RA. 1999. Enhanced ornithine decarboxylase activity is associated with attenuated rate of damage evolution and reduction of infarct volume in transient middle cerebral artery occlusion in the rat. BRAIN RESEARCH 826: 325-329. 1999
• Gröhn OHJ, Lukkarinen JA, Oja JME, van Zijl PCM, Ulatowski JA, Traystman RJ, Kauppinen RA. 1998. Noninvasive detection of cerebral hypoperfusion and reversible ischemia from reductions in the magnetic resonance imaging relaxation time, T2. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 18: 911-920. 1998
• Lukkarinen JA, Kauppinen RA, Gröhn OHJ, Oja JME, Sinervirta R, Järvinen A, Alhonen LI, Jänne J. 1998. Neuroprotective role of ornithine decarboxylase activation in transient focal cerebral ischaemia: a study using ornithine decarboxylase-overexpressing transgenic rats. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 10: 2046-2055. 1998
• Poptani H, Puumalainen A-M, Gröhn OH, Loimas S, Kainulainen R, Ylä-Herttuala S, Kauppinen RA. 1998. Monitoring thymidine kinase and ganciclovir-induced changes in rat malignant glioma in vivo by nuclear magnetic resonance imaging. CANCER GENE THERAPY 5 2: 101-109. 1998
• Lukkarinen J, Gröhn OHJ, Sinervirta R, Järvinen A, Kauppinen RA, Jänne J, Alhonen LI. 1997. Transgenic rats as models for studying the role of ornithine decarboxylase expression in permanent middle cerebral artery occlusion. STROKE 28 3: 639-645. 1997
• Hakumäki JM, Gröhn OHJ, Pirttilä T-RM, Kauppinen RA. 1996. Increased macromolecular resonances in the rat cerebral cortex during severe energy failure as detected by 1H nuclear magnetic resonance spectroscopy NEUROSCIENCE LETTERS 212: 151-154. 1996