PAAVO HONKAKOSKI
Professor
Paavo Honkakoski has a long experience in regulation of drug metabolizing enzymes, drug transporters and nuclear receptors and their applications to assess drug ADMET properties. He is involved in the emerging research area “Targeted Drug Delivery with Emphasis on Ocular Drug Treatment” recognized by the UEF, co-coordinator of the MSCA ITN consortium OcuTher (www.ocuther.eu) and participant in the H2020 consortium project EDCMET. He has accumulated ~3 M€ competitive research funding. He has ~110 peer-reviewed papers garnering >5100 citations. He is active in both graduate and PhD education, having supervised >50 MSc and 11 PhD theses. He is a member of several editorial boards in journals related to drug research. He has served as a director of Graduate Schools/Doctoral Programs in drug research (2008-2017) and Vice Dean of the Faculty of Health Sciences at UEF with responsibilities in research infrastructures and doctoral programs (2012-2017).
Contact info
Organization
Faculty of Health Sciences, School of Pharmacy
paavo.honkakoski@uef.fi
Phone
+358 40 355 2490
Keywords
Research groups
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EDCMET
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Genome Center of Eastern Finland
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Metabolism and transport of drugs and xenobiotics
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Ocular Drug Delivery group (ODD)
Publications
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Hammid, Anam; Fallon, John K; Lassila, Toni; Salluce, Giulia; Smith, Philip C; Tolonen, Ari; Sauer, Achim; Urtti, Arto; Honkakoski, Paavo. 2021. Carboxylesterase Activities and Protein Expression in Rabbit and Pig Ocular Tissues Molecular pharmaceutics 18 3: 1305-1316. 2021
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Küblbeck, Jenni; Vuorio, Taina; Niskanen, Jonna; Fortino, Vittorio; Braeunin, Albert; Abass, Khaled; Rautio, Arja; Hakkola, Jukka; Honkakoski, Paavo; Levonen, Anna-Liisa. 2020. The EDCMET project: Metabolic effects of endocrine disruptors International journal of molecular sciences 21 8: 3021. 2020
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Küblbeck, Jenni; Niskanen, Jonna; Honkakoski, Paavo. 2020. Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR Cells 9 10: 2306. 2020
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A Reverse Transfection Method for Screening of Nuclear Receptor Activators. Küblbeck, Jenni; Honkakoski, Paavo / Nuclear Receptors. 2019. 2019
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Giantin, M; Küblbeck, J; Zancanella, V; Prantner, V; Sansonetti, F; Schoeniger, A; Tolosi, R; Guerra, G; Da Ros, S; Dacasto, M; Honkakoski, P. 2019. DNA elements for constitutive androstane receptor- and pregnane X receptor-mediated regulation of bovine CYP3A28 gene PLoS ONE 14 3: e0214338. 2019
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Giantin, M; Rahnasto-Rilla, M; Tolosi, R; Lucatello, L; Pauletto, M; Guerra, G; Pezzato, F; Lopparelli, RM; Merlanti, R; Carnier, P; Capolongo, F; Honkakoski, P; Dacasto, M. 2019. Functional impact of cytochrome P450 3A (CYP3A) missense variants in cattle Scientific reports 9 1: 19672. 2019
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Kang, HE; Malinen, MM; Saran, C; Honkakoski, P; Brouwer, KLR. 2019. Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions Drug metabolism and disposition 47 10: 1222-1230. 2019
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Malinen, MM; Ito, K; Kang, HE; Honkakoski, P; Brouwer, KLR. 2019. Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells European journal of pharmaceutical sciences 130: 186-195. 2019
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Touloupi, K; Kublbeck, J; Magklara, A; Molnar, F; Reinisalo, M; Konstandi, M; Honkakoski, P; Pappas, P. 2019. The basis for strain-dependent rat aldehyde dehydrogenase 1A7 (ALDH1A7) gene expression Molecular pharmacology 96 5: 655-663. 2019
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Suun kautta otettujen lääkeaineiden imeytyminen. Urtti, Arto; Ruponen, Marika; Pajula, Katja; Yliperttula, Marjo; Honkakoski, Paavo; Ranta, Veli-Pekka; Kidron, Heidi; Vellonen, Kati-Sisko / Biofarmasian perusteet. 2018. 2018