Paavo Honkakoski
Professor
Professor in Biopharmacy. Head of the Discipline. Leader in courses Drug metabolism and pharmacokinetics (DMPK), Pharmacogenomics (FGEN), ADME models and pharmacokinetic calculations (ADMEL) and Advanced Literature in Biopharmacy (BSYK).
Faculty of Health Sciences, School of Pharmacy
paavo.honkakoski@uef.fi | +358 40 355 2490
Paavo Honkakoski has a long experience in regulation of drug metabolizing enzymes, drug transporters and nuclear receptors and their applications to assess drug ADMET properties. He is involved in the UEF research community “DrugTech” and a participant in the H2020 consortium project EDCMET. He has accumulated over 3 M€ competitive research funding. He has over 124 peer-reviewed papers garnering >6000 citations. He is active in both graduate and PhD education, having supervised >50 MSc and 11 PhD theses. He is a member of several editorial boards in journals related to drug research. He has served as a director of Graduate Schools/Doctoral Programs in drug research (2008-2017) and Vice Dean of the Faculty of Health Sciences at UEF with responsibilities in research infrastructures and doctoral programs (2012-2017).
Research groups
-
Metabolism and transport of drugs and xenobiotics 01.01.2010 - -
Ocular Drug Delivery group (ODD) 01.01.2010 -
Projects
Files
1 itemsPublications
41 items-
Ocular metabolism and distribution of drugs in the rabbit eye: Quantitative assessment after intracameral and intravitreal administrations
del Amo, Eva M.; Hammid, Anam; Tausch, Melanie; Toropainen, Elisa; Sadeghi, Amir; Valtari, Annika; Puranen, Jooseppi; Reinisalo, Mika; Ruponen, Marika; Urtti, Arto; Sauer, Achim; Honkakoski, Paavo. International journal of pharmaceutics 613: 121361. 2022 -
Novel Bile Acid-dependent Mechanisms of Hepatotoxicity Associated with Tyrosine Kinase Inhibitors
Saran, Chitra; Sundqvist, Louise; Ho, Henry; Niskanen, Jonna; Honkakoski, Paavo; Brouwer, Kim LR. Journal of pharmacology and experimental therapeutics 380 2: 114-125. 2022 -
Carboxylesterase Activities and Protein Expression in Rabbit and Pig Ocular Tissues
Hammid, Anam; Fallon, John K; Lassila, Toni; Salluce, Giulia; Smith, Philip C; Tolonen, Ari; Sauer, Achim; Urtti, Arto; Honkakoski, Paavo. Molecular pharmaceutics 18 3: 1305-1316. 2021 -
Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration-Insights into disease mechanisms and current therapeutic approaches
Huber, Nadine; Korhonen, Sonja; Hoffmann, Dorit; Leskelä, Stina; Rostalski, Hannah; Remes, Anne M.; Honkakoski, Paavo; Solje, Eino; Haapasalo, Annakaisa. Molecular psychiatry Published online: 19 November 2021: 1 - 10. 2021 -
Mechanism-Based Experimental Models for the Evaluation of BSEP Inhibition and DILI
Murphy, William A.; Chitra, Saran; Honkakoski, Paavo; Brouwer, Kim L.R. / Transporters and Drug-Metabolizing Enzymes in Drug Toxicity. 2021. 2021 -
Identification of Key Amino Acids that Impact Organic Solute Transporter Alpha/Beta (OSTα/ß)
Murphy, William A.; Beaudoin, James J.; Laitinen, Tuomo; Sjöstedt, Noora; Malinen, Melina M.; Ho, Henry; Swaan, Peter W.; Honkakoski, Paavo; Brouwer, Kim L.R.. Molecular pharmacology 100 6: 599-608. 2021 -
Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR
Küblbeck, Jenni; Niskanen, Jonna; Honkakoski, Paavo. Cells 9 10: 2306. 2020 -
The EDCMET project: Metabolic effects of endocrine disruptors
Küblbeck, Jenni; Vuorio, Taina; Niskanen, Jonna; Fortino, Vittorio; Braeunin, Albert; Abass, Khaled; Rautio, Arja; Hakkola, Jukka; Honkakoski, Paavo; Levonen, Anna-Liisa. International journal of molecular sciences 21 8: 3021. 2020 -
A Reverse Transfection Method for Screening of Nuclear Receptor Activators
Küblbeck, Jenni; Honkakoski, Paavo / Nuclear Receptors. 2019. 2019 -
DNA elements for constitutive androstane receptor- and pregnane X receptor-mediated regulation of bovine CYP3A28 gene
Giantin, M; Küblbeck, J; Zancanella, V; Prantner, V; Sansonetti, F; Schoeniger, A; Tolosi, R; Guerra, G; Da Ros, S; Dacasto, M; Honkakoski, P. PLoS ONE 14 3: e0214338. 2019