Riikka Kärnä

Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2)

Melero-Fernandez de Mera, RM; Arasu, UT; Kärnä, R; Oikari, S; Rilla, K; Vigetti, D; Passi, A; Heldin, P; Tammi, MI; Deen, AJ. 2019. Matrix biology. 80: 85-103

HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells

Arasu, UT; Deen, AJ; Pasonen-Seppänen, S; Heikkinen, S; Lalowski, M; Kärnä, R; Härkönen, K; Mäkinen, P; Lázaro-Ibáñez, E; Siljander, PR; Oikari, S; Levonen, AL; Rilla, K. 2019. Cellular and molecular life sciences. [Published: 09 December 2019]: 1-23

Melanocyte hyaluronan coat fragmentation enhances the UVB-induced TLR-4 receptor signaling and expression of proinflammatory mediators IL-6, IL-8, CXCL-1 and CXCL-10 via NF-κB activation

Takabe, P; Kärnä, R; Rauhala, L; Tammi, M; Tammi, R; Pasonen-Seppänen, S. 2019. Journal of investigative dermatology. 139: 1993-2003.e4

Extracellular ATP activates hyaluronan synthase 2 (HAS2) in epidermal keratinocytes via P2Y2, Ca2+-signaling, and MAPK pathways

Rauhala, L; Jokela, T; Kärnä, R; Bart, G; Takabe, P: Oikari, S; Tammi, MI; Pasonen-Seppänen, S; Tammi, RH. 2018. Biochemical journal. 475: 1755-1772

Hyaluronan metabolism enhanced during epidermal differentiation is suppressed by vitamin C

Hämäläinen, L; Kärkkäinen, E; Takabe, P; Rauhala, L; Bart, G; Kärnä, R; Pasonen-Seppänen, S; Oikari, S; Tammi, MI; Tammi, RH. 2018. British journal of dermatology. 179: 651-661

EMT induced by EGF and wounding activates hyaluronan synthesis machinery and EV shedding in rat primary mesothelial cells

Koistinen Ville, Härkönen Kai, Kärnä Riikka, Arasu Uma Thanigi, OIkari Sanna, Rilla Kirsi. 2017. Matrix biology. 63: 38-54

Human Keratinocytes Respond to Extracellular UTP by Induction of Hyaluronan Synthase 2 Expression and Increased Hyaluronan Synthesis

Jokela T, Kärnä R, Rauhala L, Bart G, Pasonen-Seppänen S, Oikari S, Tammi MI, Tammi RH. 2017. Journal of biological chemistry. 292: 4861-4872

Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles

Arasu UT, Kärnä R, Härkönen K, Oikari S, Koistinen A, Kröger H, Qu C, Lammi MJ, Rilla K. 2017. Matrix biology. 64: 54-68

Hexosamine biosynthesis in keratinocytes: roles of GFAT and GNPDA enzymes in the maintenance of UDP-GlcNAc content and hyaluronan synthesis

Oikari Sanna, Makkonen Katri, Deen Ashik Jawahar, Tyni Ilari, Kärnä Riikka, Tammi Raija H, Tammi Markku I. 2016. Glycobiology. 26: 710-722

Hyaluronan-positive plasma membrane protrusions exist on mesothelial cells in vivo

Koistinen Ville, Jokela Tiina, Oikari Sanna, Kärnä Riikka, Tammi Markku, Rilla Kirsi. 2016. Histochemistry and cell biology. 145: 531-544

UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression

Deen AJ, Arasu UT, Pasonen-Seppänen S, Hassinen A, Takabe P, Wojciechowski S, Kärnä R, Rilla K, Kellokumpu S, Tammi R, Tammi M, Oikari S. 2016. Cellular and molecular life sciences. 73: 3183-3204

Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia

Koistinen Ville, Kärnä Riikka, Koistinen Arto, Arjonen Antti, Tammi Markku, Rilla Kirsi. 2015. Experimental cell research. 337: 179-191

Interleukin-1ß-induced Reduction of CD44 Ser-325 Phosphorylation in Human Epidermal Keratinocytes Promotes CD44 Homomeric Complexes, Binding to Ezrin, and Extended, Monocyte-adhesive Hyaluronan Coats

Jokela Tiina, Oikari Sanna, Takabe Piia, Rilla Kirsi, Kärnä Riikka, Tammi Markku, Tammi Raija. 2015. Journal of biological chemistry. 290: 12379-12393

Extracellular UDP-Glucose Activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 Phosphorylation and Binding to Hyaluronan Synthase 2 (HAS2) Promoter, Stimulating Hyaluronan Synthesis of Keratinocytes

Jokela Tiina A, Kärnä Riikka, Makkonen Katri M, Laitinen Jarmo T, Tammi Raija H, Tammi Markku I. 2014. Journal of biological chemistry. 289: 18569-81

Rab10-mediated endocytosis of the hyaluronan synthase HAS3 regulates hyaluronan synthesis and cell adhesion to collagen

Deen Ashik Jawahar, Rilla Kirsi, Oikari Sanna, Kärnä Riikka, Bart Genevieve, Häyrinen Jukka, Bathina Avinash Rahul, Ropponen Antti, Makkonen Katri, Tammi Raija H, Tammi Markku I. 2014. Journal of biological chemistry. 289: 8375-89

Hyaluronan production enhances shedding of plasma membrane-derived microvesicles

Rilla K, Pasonen-Seppänen S, Deen AJ, Koistinen VVT, Wojciechowski S, Oikari S, Kärnä R, Bart G, Törrönen K, Tammi RH, Tammi MI. 2013. Experimental cell research. 319: 2006-2018

Hyaluronan synthase 1 (HAS1) produces a cytokine- and glucose-inducible, CD44-dependent cell surface coat

Siiskonen H, Kärnä R, Hyttinen JM, Tammi RH, Tammi MI, Rilla K. 2013. Experimental cell research. online: -

Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GIcNAc concentration than HAS2 and HAS3

Rilla K, Oikari S, Jokela TA, Hyttinen JMT, Kärnä R, Tammi RH, Tammi MI. 2013. Journal of biological chemistry. 288: 5973-5983

Mannose reduces hyaluronan and leukocytes in wound granulation tissue and inhibits migration and hyaluronan-dependent monocyte binding

Jokela TA, Kuokkanen J, Kärnä R, Pasonen-Seppänen S, Rilla K, Kössi J, Laato M, Tammi RH, Tammi MI. 2013. Wound repair and regeneration. 21: 247-255

Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes

Törrönen K, Nikunen K, Kärnä R, Tammi M, Tammi R, Rilla K. 2013. Histochemistry and cell biology. 140: -

Hyaluronan in cytosol - microinjection-based probing of its existence and suggested functions

Siiskonen H, Rilla K, Kärnä R, Bart G, Jing W, Haller MF, DeAngelis PL, Tammi RH, Tammi MI. 2012. Glycobiology. online: -

Cellular Content of UDP-N-acetylhexosamines Controls Hyaluronan Synthase 2 Expression and Correlates with O-Linked N-Acetylglucosamine Modification of Transcription Factors YY1 and SP1

Jokela Tiina A, Makkonen Katri M, Oikari Sanna, Kärnä Riikka, Koli Elina, Hart Gerald W, Tammi Raija H, Tammi Markku I. 2011. Journal of biological chemistry. 289: 33632-33640

HAS3-induced accumulation of hyaluronan in 3D MDCK cultures results in mitotic spindle misorientation and disturbed organization of epithelium

Rilla Kirsi, Pasonen-Seppänen Sanna, Kärnä Riikka, Karjalainen Hannu M, Törrönen Kari, Koistinen Ville, Tammi Markku I, Tammi Raija H, Teräväinen Terhi, Manninen Aki. 2011. Histochemistry and cell biology. 137: 153-164

Methyl-&#946 -cyclodetextrin suppresses hyaluronan synthesis by down-regulation of hyaluronan synthase 2 through inhibition of Akt

Kultti A, Kärnä R, Rilla K, Nurminen P, Koli E, Makkonen KM, Si J, Tammi MI & Tammi R. 2010. Journal of biological chemistry. 285: 22901-22910

4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3

Kultti A, Pasonen-Seppänen S, Jauhiainen Marjo, Rilla KJ, Kärnä R, Pyöriä E, Tammi RH, Tammi MI. 2009. Experimental cell research. 315: 1914-1923

Mannose inhibits hyaluronan synthesis by down-regulation of the cellular pool of UDP-N-acetylhexosamines

Jokela TA, Jauhiainen M, Auriola S, Kauhanen M, Tiihonen R, Tammi MI, Tammi RH. 2008. Journal of biological chemistry. 283: 7666-7673

Pericellular hyaluronan coat visualized in live cells with a fluorescent probe is scaffolded by plasma membrane protrusions

Rilla K, Tiihonen R, Kultti A, Tammi M, Tammi R. 2008. Journal of histochemistry and cytochemistry. 56: 901-910

Hyaluronan synthesis induces microvillus-like cell surface protrusions

Kultti A, Rilla K, Tiihonen R, Spicer AP, Tammi R, Tammi M. 2006. Journal of biological chemistry. 281: 15821-15828

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Publications

Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2)

HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells

Melanocyte hyaluronan coat fragmentation enhances the UVB-induced TLR-4 receptor signaling and expression of proinflammatory mediators IL-6, IL-8, CXCL-1 and CXCL-10 via NF-κB activation

Extracellular ATP activates hyaluronan synthase 2 (HAS2) in epidermal keratinocytes via P2Y2, Ca2+-signaling, and MAPK pathways

Hyaluronan metabolism enhanced during epidermal differentiation is suppressed by vitamin C

EMT induced by EGF and wounding activates hyaluronan synthesis machinery and EV shedding in rat primary mesothelial cells

Human Keratinocytes Respond to Extracellular UTP by Induction of Hyaluronan Synthase 2 Expression and Increased Hyaluronan Synthesis

Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles

Hexosamine biosynthesis in keratinocytes: roles of GFAT and GNPDA enzymes in the maintenance of UDP-GlcNAc content and hyaluronan synthesis

Hyaluronan-positive plasma membrane protrusions exist on mesothelial cells in vivo

UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression

Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia

Interleukin-1ß-induced Reduction of CD44 Ser-325 Phosphorylation in Human Epidermal Keratinocytes Promotes CD44 Homomeric Complexes, Binding to Ezrin, and Extended, Monocyte-adhesive Hyaluronan Coats

Extracellular UDP-Glucose Activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 Phosphorylation and Binding to Hyaluronan Synthase 2 (HAS2) Promoter, Stimulating Hyaluronan Synthesis of Keratinocytes

Rab10-mediated endocytosis of the hyaluronan synthase HAS3 regulates hyaluronan synthesis and cell adhesion to collagen

Hyaluronan production enhances shedding of plasma membrane-derived microvesicles

Hyaluronan synthase 1 (HAS1) produces a cytokine- and glucose-inducible, CD44-dependent cell surface coat

Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GIcNAc concentration than HAS2 and HAS3

Mannose reduces hyaluronan and leukocytes in wound granulation tissue and inhibits migration and hyaluronan-dependent monocyte binding

Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes

Hyaluronan in cytosol - microinjection-based probing of its existence and suggested functions

Cellular Content of UDP-N-acetylhexosamines Controls Hyaluronan Synthase 2 Expression and Correlates with O-Linked N-Acetylglucosamine Modification of Transcription Factors YY1 and SP1

HAS3-induced accumulation of hyaluronan in 3D MDCK cultures results in mitotic spindle misorientation and disturbed organization of epithelium

Methyl-&#946 -cyclodetextrin suppresses hyaluronan synthesis by down-regulation of hyaluronan synthase 2 through inhibition of Akt

4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3

Mannose inhibits hyaluronan synthesis by down-regulation of the cellular pool of UDP-N-acetylhexosamines

Pericellular hyaluronan coat visualized in live cells with a fluorescent probe is scaffolded by plasma membrane protrusions

Hyaluronan synthesis induces microvillus-like cell surface protrusions