Sami Heikkinen

Gharahkhani, Puya; Jorgenson, Eric; Hysi, Pirro; Khawaja, Anthony P; Pendergrass, Sarah; Han, Xikun; Ong, Jue Sheng; Hewitt, Alex W; Segrè, Ayellet V; Rouhana, John M; Hamel, Andrew R; Igo, Robert P; Choquet, Helene; Qassim, Ayub; Josyula, Navya S; Cooke Bailey, Jessica N; Bonnemaijer, Pieter W M; Iglesias, Adriana; Siggs, Owen M; Young, Terri L et al. [incl FinGen; Mannermaa, Arto; Heikkinen, Sam. 2021. Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries Nature communications 12 1: 1258. 2021

Kärkkäinen, Emmi; Heikkinen, Sami; Tengström, Maria; Kosma, Veli-Matti; Mannermaa, Arto; Hartikainen, Jaana M. 2021. The debatable presence of PIWI-interacting RNAs in invasive breast cancer Cancer medicine 10 11: 3593 - 3603. 2021

Malmberg, Henna-Riikka; Hanel, Andrea; Taipale, Mari; Heikkinen, Sami; Carlberg, Carsten. 2021. Vitamin D Treatment Sequence Is Critical for Transcriptome Modulation of Immune Challenged Primary Human Cells Frontiers in immunology 12: 754056. 2021

Nordberg, Maria-Elisa; Täubel, Martin; Heikkinen, Sami; Jalkanen, Kaisa; Köliö, Arto; Stranger, Marianne; Leppanen, Hanna; Hyvärinen, Anne; Huttunen, Kati. 2021. Toxicological transcriptome of human airway constructs after exposure to indoor air particulate matter: In search of relevant pathways of moisture damage-associated health effects Environment international 2022; 158: 106997. 2021

Palomäki, Antti; FinnGen Rheumatology Clinical Expert Group; Palotie, Aarno; Koskela, Jukka; Eklund, Kari K; Pirinen, Matti; FinnGen; Ripatti, Samuli; Laitinen, Tarja; Mars, Nina; [incl. collaborators Kosma, Veli-Matti; Mannermaa, Arto; Heikkinen, Sami]. 2021. Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in MUC5B mutation carriers Annals of the rheumatic diseases 80 12: 1530-1536. 2021

Selvarajan, Ilakya; Toropainen, Anu; Garske, Kristina M.; López Rodríguez, Maykel; Ko, Arthur; Miao, Zong; Kaminska, Dorota; Õunap, Kadri; Örd, Tiit; Ravindran, Aarthi; Liu, Oscar H.; Moreau, Pierre R.; Jawahar Deen, Ashik; Männistö, Ville; Pan, Calvin; Levonen, Anna-Liisa; Lusis, Aldons J.; Heikkinen, Sami; Romanoski, Casey E.; Pihlajamäki, Jussi; Pajukanta, Päivi; Kaikkonen, Minna U.. 2021. Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease American journal of human genetics 108 3: 411-430. 2021

Sun, Daokun; Richard, Melissa A.; Musani, Solomon K.; Sung, Yun Ju; Winkler, Thomas W.; Schwander, Karen; Chai, Jin Fang; Guo, Xiuqing; Kilpeläinen, Tuomas O.; Vojinovic, Dina; Aschard, Hugues; Bartz, Traci M.; Bielak, Lawrence F.; Brown, Michael R.; Chitrala, Kumaraswamy; Hartwig, Fernando P.; Horimoto, Andrea R.V.R.; Liu, Yongmei; Manning, Alisa K.; Noordam, Raymond et al. [incl. Heikkinen, Sam. 2021. Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits Human Genetics and Genomics Advances 2 1: 100013. 2021

Wang, Heming; Noordam, Raymond; Cade, Brian E.; Schwander, Karen; Winkler, Thomas W.; Lee, Jiwon; Sung, Yun Ju; Bentley, Amy R.; Manning, Alisa K.; Aschard, Hugues; Kilpeläinen, Tuomas O.; Ilkov, Marjan; Brown, Michael R.; Horimoto, Andrea R.; Richard, Melissa; Bartz, Traci M.; Vojinovic, Dina; Lim, Elise; Nierenberg, Jovia L.; Liu, Yongmei et al. [incl. Heikkinen, Sami]. 2021. Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure Molecular psychiatry 26 11: 6293-6304. 2021

Zekavat, Seyedeh M.; Lin, Shu-Hong; Bick, Alexander G.; Liu, Aoxing; Paruchuri, Kaavya; Wang, Chen; Uddin, Md Mesbah; Ye, Yixuan; Yu, Zhaolong; Liu, Xiaoxi; Kamatani, Yoichiro; Bhattacharya, Romit; Pirruccello, James P.; Pampana, Akhil; Loh, Po-Ru; Kohli, Puja; McCarroll, Steven A.; Kiryluk, Krzysztof; Neale, Benjamin; Ionita-Laza, Iuliana et al. [incl. Mannermaa, Arto; Heikkinen, Sami; Kosma, Vel. 2021. Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection Nature medicine 27 6: 1012-1024. 2021

Bao, Erik L; Nandakumar, Satish K; Liao, Xiaotian; Bick, Alexander G; Karjalainen, J; Tabaka, Marcin; Gan, Olga I; Havulinna, Aki S; Kiiskinen, Tuomo TJ; Lareau, Caleb A; de Lapuente Portilla, Aitzkoa L; Li, Bo; Emdin, Connor; Codd, Veryan; Nelson, Christopher P; Walker, Christopher J; Churchhouse, Claire; de la Chapelle, Albert; Klein, Daryl E; et al. (incl. Kosma, V-M; Heikkinen, S; Mannermaa, A. 2020. Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells Nature 586 7831: 769-775. 2020

de Las Fuentes, Lisa; Sung, Yun Ju; Noordam, Raymond; Winkler, Thomas; Feitosa, Mary F; Schwander, Karen; Bentley, Amy R; Brown, Michael R; Guo, Xiuqing; Manning, Alisa; Chasman, Daniel I; Aschard, Hugues; Bartz, Traci M; Bielak, Lawrence F; Campbell, Archie; Cheng, Ching-Yu; Dorajoo, Rajkumar; Hartwig, Fernando P; Horimoto, A R V R; Li, Changwei et al [incl. Heikkinen, Sami; Lakka, Timo]. 2020. Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci Molecular psychiatry 2021; 26 6: 2111-2125. 2020

Eneh, Stralina; Heikkinen, Sami; Hartikainen, Jaana M; Kuopio, Teijo; Mecklin, Jukka-Pekka; Kosma, Veli-Matti; Mannermaa, Arto. 2020. MicroRNAs Associated With Biological Pathways of Left- And Right-sided Colorectal Cancer Anticancer research 40 7: 3713-3722. 2020

Mars, Nina; Widén, Elisabeth; Kerminen, Sini; Meretoja, Tuomo; Pirinen, Matti; Parolo, Pietro della Briotta; Palta, Priit; FinnGen, Palotie, Aarno; Kaprio, Jaakko; Joensuu, Heikki; Daly, Mark; Ripatti, Samuli [incl. Hiltunen, Mikko; Heikkinen, Sami; Julkunen, Valtteri; Kosma, Veli-Matti; Mannermaa, Arto; Kälviäinen, Reetta]. 2020. The role of polygenic risk and susceptibility genes in breast cancer over the course of life Nature communications 11 1: 6383. 2020

Viitasalo, A; Schnurr, TM; Pitkänen, N; Hollensted, M; Nielsen, TRH; Pahkala, K; Atalay, M; Lind, MV; Heikkinen, S; Frithioff-Bøjsøe, C; Fonvig, CE; Grarup, N; Kähönen, M; Carrasquilla, GD; Larnkjaer, A; Pedersen, O; Michaelsen, KF; Lakka, TA; Holm, JC; Lehtimäki, T; et al.. 2019. Abdominal adiposity and cardiometabolic risk factors in children and adolescents: a Mendelian randomization analysis American journal of clinical nutrition 110 5: 1079-1087. 2019

Tabassum, Rubina; Ramo, Joel T; Ripatti, Pietari; Koskela, Jukka T; Kurki, Mitja; Karjalainen, Juha; Palta, Priit; Hassan, Shabbeer; Nunez-Fontarnau, Javier; Kiiskinen, Tuomo T J; Söderlund, Sanni; Matikainen, Niina; Gerl, Mathias J; Surma, Michal A; Klose, Christian; Stitziel, Nathan O; Laivuori, Hannele; Havulinna, Aki S; Service, Susan K; Salomaa, Veikko et al. (Incl Mannermaa, Arto; Heikkinen,. 2019. Genetic architecture of human plasma lipidome and its link to cardiovascular disease Nature communications 10: 4329. 2019

Sung, Yun Ju; de Las Fuentes, Lisa; Winkler, Thomas W; Chasman, Daniel I; Bentley, Amy R; Kraja, Aldi T; Ntalla, Ioanna; Warren, Helen R; Guo, Xiuqing; Schwander, Karen; Manning, Alisa K; Brown, Michael R; Aschard, Hugues; Feitosa, Mary F; Franceschini, Nora; Lu, Yingchang; et al. (incl. Heikkinen, Sami; Kuusisto, Johanna; Laakso, Markku; Stancáková, Alena; Lakka, Timo A). 2019. A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure Human molecular genetics 28 15: 2615-2633. 2019

Noordam, R; Bos, MM; Wang, H; Winkler, TW; Bentley, AR; Kilpeläinen, TO; de Vries, PS; Sung, YJ; Schwander, K; Cade, BE; Manning, A; Aschard, H; Brown, MR; Chen, H; Franceschini, N; Musani, SK; Richard, M; Vojinovic, D; Aslibekyan, S; Bartz, TM; et al. (incl. Heikkinen, S). 2019. Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration Nature communications 10: 5121. 2019

Kilpeläinen, TO; Bentley, AR; Noordam, R; Sung, YJ; Schwander, K; Winkler, TW; Jakupovic, H; Chasman, DI; Manning, A; Ntalla, I; Aschard, H; Brown, MR; de Las Fuentes, L; Franceschini, N; Guo, X; Vojinovic, D; Aslibekyan, S; Feitosa, MF; Kho, M; Musani, SK; et al. [Incl. Lakka, Timo; Heikkinen, Sami; Kuusisto, Johanna; Laakso, Markku]. 2019. Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity Nature communications 10 1: 376. 2019

de Vries, PS; Brown, MR; Bentley, AR; Sung, YJ; Winkler, TW; Ntalla, I; Schwander, K; Kraja, AT; Guo, X; Franceschini, N; Cheng, CY; Sim, X; Vojinovic, D; Huffman, JE; Musani, SK; Li, C; Feitosa, MF; Richard, MA; Noordam, R; Aschard, H; et al. (Incl. Kuusisto, Johanna; Laakso, Markku; Lakka, Timo; Heikkinen, Sami). 2019. Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions American journal of epidemiology 188 6: 1033-1054. 2019

Bentley, AR; Sung, YJ; Brown, MR; Winkler, TW; Kraja, AT; Ntalla, I; Schwander, K; Chasman, DI; Lim, E; Deng, X; Guo, X; Liu, J; Lu, Y; Cheng, CY; Sim, X; Vojinovic, D; Lakka, TA; Heikkinen, S; Kuusisto, J; Laakso, M; et al. (incl. Laakso, Markku; Heikkinen, Sami; Kuusisto, Johanna; Lakka, Timo; Rauramaa, Rainer). 2019. Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids Nature genetics 51 4: 636-648. 2019

Arasu, UT; Deen, AJ; Pasonen-Seppänen, S; Heikkinen, S; Lalowski, M; Kärnä, R; Härkönen, K; Mäkinen, P; Lázaro-Ibáñez, E; Siljander, PR; Oikari, S; Levonen, AL; Rilla, K. 2019. HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells Cellular and molecular life sciences [Published: 09 December 2019]: 1-23. 2019

Chen, Xi; Ayala, Iriscilla; Shannon, Chris; Fourcaudot, Marcel; Acharya, Nikhil K; Jenkinson, Christopher P; Heikkinen, Sami; Norton, Luke. 2018. The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function. DIABETES (NY) 67 4: 554-568. 2018

Feitosa, MF; Kraja, AT; Chasman, DI; Sung, YJ; Winkler, TW; Ntalla, I; Guo, X; Franceschini, N; Cheng, CY; Sim, X; Vojinovic, D; Marten, J; Musani, SK; Li, C; Bentley, AR; Brown, MR; Schwander, K; Richard, MA; Noordam, R; Aschard, H; et al. (incl. Laakso, Markku; Heikkinen, Sami; Kuusisto, Johanna; Lakka, Timo; Yaluri, Alena). 2018. Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries PLoS ONE 13 6: e0198166. 2018

Sung, YJ; Winkler, TW; de Las Fuentes, L; Bentley, AR; Brown, MR; Kraja, AT; Schwander, K; Ntalla, I; Guo, X; Franceschini, N; Lu, Y; Cheng, CY; Sim, X; Vojinovic, D; Marten, J; Musani, SK; Li, C; Feitosa, MF; Kilpeläinen, TO; Richard, MA et al. (incl. Yaluri, Alena; Heikkinen, Sami; Kuusisto, Johanna; Laakso, Markku). 2018. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure American journal of human genetics 102 3: 375-400. 2018

Kuosmanen SM, Kansanen E, Kaikkonen MU, Sihvola V, Pulkkinen K, Jyrkkänen H-K, Tuoresmäki P, Hartikainen J, Hippeläinen M, Kokko H, Tavi P, Heikkinen S, Levonen A-M. 2017. NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation. NUCLEIC ACIDS RESEARCH 2018; 46 3: 1124-1138. 2017

Singh PK, van den Berg PR, Long MD, Vreugdenhil A, Grieshober L, Ochs-Balcom HM, Wang J, Delcambre S, Heikkinen S, Carlberg C, Campbell MJ, Sucheston-Campbell LE. 2017. Integration of VDR genome wide binding and GWAS genetic variation data reveals co-occurrence of VDR and NF-kappaB binding that is linked to immune phenotypes. BMC Genomics 18 1: -. 2017

Kuosmanen Suvi M, Viitala Sari, Laitinen Tuomo, Peräkylä Mikael, Pölönen Petri, Kansanen Emilia, Leinonen Hanna, Raju Suresh, Wienecke-Baldacchino Anke, Närvänen Ale, Poso Antti, Heinäniemi Merja, Heikkinen Sami, Levonen Anna-Liisa. 2016. The Effects of Sequence Variation on Genome-wide NRF2 Binding - New Target Genes and Regulatory SNPs. NUCLEIC ACIDS RESEARCH 44 4: 1760-1775. 2016

Dali-Youcef Nassim, Froelich Sébastian, Moussallieh Francois-Marie, Chibbaro Salvatore, Noël Georges, Namer Izzie J., Heikkinen Sami, Auwerx Johan. 2015. Gene Expression Mapping of Histone Deacetylases and Co-factors, and Correlation with Survival Time and 1H-HRMAS Metabolomic Profile in Human Gliomas. Scientific Reports 5: 10 pages. 2015

Norton Luke, Chen Xi, Fourcaudot Marcel, Acharya Nikhil K, DeFronzo Ralph A, Heikkinen Sami. 2014. The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells. NUCLEIC ACIDS RESEARCH 42 22: 13646-13661. 2014

Nurminen Veijo, Neme Antonio, Ryynänen Jussi, Heikkinen Sami, Seuter Sabine, Carlberg Carsten. 2014. The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D. BIOCHIMICA ET BIOPHYSICA ACTA - GENE REGULATORY MECHANISMS Epub ahead of print: -. 2014

Sutinen Päivi, Malinen Marjo, Heikkinen Sami, Palvimo Jorma J. 2014. SUMOylation modulates the transcriptional activity of androgen receptor in a target gene and pathway selective manner. NUCLEIC ACIDS RESEARCH 42 13: 8310-9. 2014

Tuoresmäki Pauli, Väisänen Sami, Neme Antonio, Heikkinen Sami, Carlberg Carsten. 2014. Patterns of Genome-Wide VDR Locations. PLOS ONE [ONLINE] 9 4: e96105. 2014

Seuter S, Pehkonen P, Heikkinen S, Carlberg C. 2013. Dynamics of 1α,25-dihydroxyvitamin D3-dependent chromatin accessibility of early vitamin D receptor target genes. BIOCHIMICA ET BIOPHYSICA ACTA 1829: 1266-1275. 2013

Seuter S, Pehkonen P, Heikkinen S, Carlberg C. 2012. The gene for the transcription factor BHLHE40/DEC1/stra13 is a dynamically regulated primary target of the vitamin D receptor. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY online [Epub ahead of print]: -. 2012

Seuter S, Heikkinen S, Carlberg C. 2012. Chromatin acetylation at transcription start sites and vitamin D receptor binding regions relates to effects of 1alfa,25-dihydroxyvitamin D3 and histone deacetylase inhibitors on gene expression. NUCLEIC ACIDS RESEARCH -: -. 2012

Pehkonen P, Welter-Stahl L, Diwo J, Ryynänen J, Wienecke-Baldacchino A, Heikkinen S, Treuter E, Steffensen K, Carlberg C. 2012. Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages. BMC GENOMICS [ONLINE:HTTP://WWW.BIOMEDCENTRAL.COM/BMCGENOMICS/] 13 50: -. 2012

Malinen M, Jääskeläinen T, Pelkonen M, Heikkinen S, Väisänen S, Kosma VM, Nieminen K, Mannermaa A, Palvimo JJ. 2012. Proto-oncogene PIM-1 is a novel estrogen receptor target associating with high grade breast tumors Molecular and cellular endocrinology 2013; 365 2: 270-276. 2012

Koponen T, Cerrada-Gimenez M, Pirinen E, Hohtola E, Paananen J, Vuohelainen S, Tusa M, Pirnes-Karhu S, Heikkinen S, Virkamäki A, Uimari A, Alhonen L, Laakso M.. 2012. The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis. AMINO ACIDS 42: 427-440. 2012

Carlberg C, Seuter S, Heikkinen S. 2012. The First Genome-wide View of Vitamin D Receptor Locations and Their Mechanistic Implications. ANTICANCER RESEARCH 32 1: 271-282. 2012

Heikkinen Sami, Väisänen Sami, Pehkonen Petri, Seuter Sabine, Benes Vladimir, Carlberg Carsten. 2011. Nuclear hormone 1α,25-dihydroxyvitamin D3 elicits a genome-wide shift in the locations of VDR chromatin occupancy. NUCLEIC ACIDS RESEARCH 39 21: 9181-9193. 2011

Pirinen E, Gylling H, Itkonen P, Yaluri N, Heikkinen S, Pietilä M, Kuulasmaa T, Tusa M, Cerrada-Gimenez M, Pihlajamäki J, Alhonen L, Jänne J, Miettinen TA & Laakso M. 2010. Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis. AMINO ACIDS 38: 549-560. 2010

Sari Toropainen, Sami Väisänen, Sami Heikkinen,Carsten Carlberg. 2010. The Down-regulation of the Human MYC Gene by the Nuclear Hormone 1α,25-dihydroxyvitamin D3 is Associated with Cycling of Corepressors and Histone Deacetylases. JOURNAL OF MOLECULAR BIOLOGY 400 3: 284-294. 2010

Smeele KM, Eerbeek O, Koeman A, Bezemer R, Ince C, Heikkinen S, Laakso M, de Haan A, Schaart G, Drost MR, et al. 2010. Partial hexokinase II knocout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY 459: 705-712. 2010

Pirinen E, Kuulasmaa T, Pietilä M, Heikkinen S, Tusa M, Itkonen P, Boman S, Skommer J, Virkamäki A, Hohtola E, Kettunen M, Fatrai S, Kansanen E, Koota S, Niiranen K, Parkkinen J, Levonen A-L, Ylä-Herttuala S, Hiltunen JK, Alhonen L, Smith U, Jänne J. 2007. Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism MOLECULAR AND CELLULAR BIOLOGY 27 13: 4953-4967. 2007

Gofflot F, Chartoire N, Vasseur L, Heikkinen S, Dembele D, Le Merrer J, Auwerx J. 2007. Systematic gene expression mapping clusters nuclear receptors according to their function in the brain. CELL 131 2: 405-418. 2007

Heikkinen S, Auwerx J, Argmann CA. 2007. PPARgamma in human and mouse physiology. BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR AND CELL BIOLOGY OF LIPIDS 1771 8: 999-1013. 2007

Fueger PT, Lee-Young RS, Shearer J, Bracy DP, Heikkinen S, Laakso M, Rottman JN, Wasserman DH. 2007. Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat-fed mice. Studies in mice with a 50 % reduction of hexokinase II. DIABETES (NY) 56: 2476-2484. 2007

Hyvönen MT, Uimari A, Keinänen TA, Heikkinen S, Pellinen R, Wahlfors T, Korhonen A, Närvänen A, Wahlfors J, Alhonen L, Jänne J. 2006. Polyamine-regulated unproductive splicing and translation of spermidine/spermine N1 -acetyltransferase RNA (NEW YORK, N.Y.) 12 8: 1569-1582. 2006

Määttä A-M, Korja S, Venhoranta H, Hakkarainen T, Pirinen E, Heikkinen S, Pellinen R, Mäkinen K, Wahlfors J. 2006. Transcriptional targeting of virus-mediated gene transfer by the human hexokinase II promoter. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 18: 901-908. 2006

Niiranen K, Keinänen TA, Pirinen E, Heikkinen S, Tusa M, Fatrai S, Suppola S, Pietilä M, Uimari A, Laakso M, Alhonen L, Jänne J. 2006. Mice with targeted disruption of spermidine/spermine N1-acetyltransferese gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 10: 933-945. 2006

Rautsi O, Lehmusvaara S, Salonen T, Häkkinen K, Sillanpää M, Hakkarainen T, Heikkinen S, Vähäkangas E, Ylä-Herttuala S, Hinkkanen A, Julkunen I, Wahlfors J, Pellinen R. 2006. Type I interferon response against viral and non-viral gene transfer in human tumor and primary cell lines. JOURNAL OF GENE MEDICINE 9 2: 122-135. 2006

Fueger PT, Shearer J, Krueger TM, Posey KA, Bracy DP, Heikkinen S, Laakso M, Rottman JN, Wasserman DH. 2005. Hexokinase II protein content is a determinant of exercise endurance capacity in the mouse. JOURNAL OF PHYSIOLOGY (CAMBRIDGE) 566 2: 533-541. 2005

The Tenth Annual Post-Graduate Symposium of the A.I. Virtanen Institute Graduate School. AIVI Winter School 2005. Abstracts. Keinänen R, Heikkinen S, Huttunen J, Koskinen R, Mäntylä T, Peltonen H. 2005 2005

Pirinen E, Heikkinen S, Malkki M, Deep SS, Jänne J, Laakso M. 2004. Analysis of the human hexokinase II promoter in vivo: lack of insulin response within 4.0 kb. BIOCHIMICA ET BIOPHYSICA ACTA - GENE STRUCTURE AND EXPRESSION 1676: 149-154. 2004

Heikkinen S. 2004. Glucose Metabolism in Heterozygous Hexokinase II Knock-out Mice. Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti. 2004

Fueger PT, Heikkinen S, Bracy DP, Malabanan CM, Pencek RR, Laakso M, Wasserman DH. 2003. Hexokinase II partial knockout impairs exercise-stimulated glucose uptake in oxidative muscles of mice. AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM [PRINTED AND ONLINE: HTTP://AJPENDO.PHYSIOLOGY.ORG/] 285: E958-E963. 2003

Jääskeläinen P, Kuusisto J, Miettinen R, Kärkkäinen P, Kärkkäinen S, Heikkinen S, Peltola P, Pihlajamäki J, Vauhkonen I, Laakso M. 2002. Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland JOURNAL OF MOLECULAR MEDICINE 80: 412-422. 2002

Suppola S, Heikkinen S, Parkkinen JJ, Uusi-Oukari M, Korhonen V-P, Keinänen T, Alhonen L, Jänne J. 2001. Concurrent overexpression of ornithine decarboxylase and spermidine/spermine N1-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice BIOCHEMICAL JOURNAL 358: 343-348. 2001

Heikkinen S, Suppola S, Malkki M, Deeb SS, Jänne J, Laakso M. 2000. Mouse hexokinase II gene: structure, cDNA, promoter analysis, and expression pattern. MAMMALIAN GENOME (NEW YORK NY) 11: 91-96. 2000

Heikkinen S, Pietilä M, Halmekytö M, Suppola S, Pirinen E, Deeb SS, Jänne J, Laakso M. 1999. Hexokinase II-deficient mice: prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes. JOURNAL OF BIOLOGICAL CHEMISTRY 274: 22517-22523. 1999

Pulkkinen A, Kareinen A, Saarinen L, Heikkinen S, Lehto S, Laakso M. 1999. The codon 64 polymorphism of the beta3-adrenergic receptor gene is not associated with coronary heart disease or insulin resistance in nondiabetic subjects and non-insulin-dependent diabetic patients METABOLISM: CLINICAL AND EXPERIMENTAL 48: 853-856. 1999

Valve R, Heikkinen S, Rissanen A, Laakso M, Uusitupa M. 1998. Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on basal metabolic rate in obese Finns. DIABETOLOGIA 41: 357-361. 1998

Saarinen L, Pulkkinen A, Kareinen A, Heikkinen S, Lehto S, Laakso M. 1998. Variants of the fatty acid-binding protein 2 gene are not associated with coronary heart disease in nondiabetic subjects and in patients with NIDDM. DIABETES CARE 21: 849-850. 1998

Rissanen J, Saarinen L, Heikkinen S, Kekäläinen P, Mykkänen L, Kuusisto J, Deeb SS, Laakso M. 1998. Glucokinase gene islet promoter region variant (G->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns DIABETES CARE 21: 1194-1197. 1998

Pihlajamäki J, Rissanen J, Valve R, Heikkinen S, Karjalainen L, Laakso M. 1998. Different regulation of free fatty acid levels and glucose oxidation by the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and the promoter variant (A-3826G) of the uncoupling protein 1 gene in familial combined hyperlipidemia. METABOLISM: CLINICAL AND EXPERIMENTAL 47 11: 1397-1402. 1998

Pihlajamäki J, Rissanen J, Heikkinen S, Karjalainen L, Laakso M. 1997. Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 17: 1039-1044. 1997

Rissanen J, Kuopusjärvi M, Pihlajamäki J, Sipiläinen R, Heikkinen S, Vanhala M, Kekäläinen P, Kuusisto J, Laakso M. 1997. The trp64arg polymorphism of the beta3-adrenergic receptor gene DIABETES CARE 20 8: 1319-1323. 1997

Rissanen J, Pihlajamäki J, Heikkinen S, Kekäläinen P, Kuusisto J, Laakso M. 1997. The ala54thr polymorphism of the fatty acid binding protein 2 gene does not influence insulin sensitivity in Finnish nondiabetic and NIDDM subjects. DIABETES (NY) 46: 711-712. 1997

Rissanen J, Pihlajamäki J, Heikkinen S, Kekäläinen P, Mykkänen L, Kuusisto J, Kolle A, Laakso M. 1997. New variants in the glycogen synthase gene (GIn71His, Met416Val) in patients with NIDDM from eastern Finland. DIABETOLOGIA 40: 1313-1319. 1997

Sipiläinen R, Uusitupa M, Heikkinen S, Rissanen A, Laakso M. 1997. Polymorphism of the Beta3-adrenergic receptor gene affects basal metabolic rate in obese Finns DIABETES (NY) 46: 77-80. 1997

Sipiläinen R, Uusitupa M, Heikkinen S, Rissanen A, Laakso M. 1997. Variants in the human intestinal fatty acid binding protein 2 gene in obese subjects. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 82: 2629-2632. 1997

Vidgren HM, Sipiläinen RH, Heikkinen S, Laakso M, Uusitupa MIJ. 1997. Threonine allele in codon 54 of the fatty acid binding protein 2 gene does not modify the fatty acid composition of serum lipids in obese subjects. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 27: 405-408. 1997

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