Sami Heikkinen
Research Director
Institute of Biomedicine, School of Medicine, Faculty of Health Sciences
[email protected] | +358 40 355 3393
Research groups
Publications
97/104 items-
Biobank-based genetic characterization of neurodegenerative diseases and idiopathic normal pressure hydrocephalus: insights and lessons learned from FinnGen
Heikkinen, Sami; Julkunen, Valtteri; Martiskainen, Henna; Takalo, Mari; Solje, Eino; Leinonen, Ville; Haapasalo, Annakaisa; Lipponen, Anssi; Hiltunen, Mikko, 2026, Molecular psychiatry, [Published: 12 June 2026], 1-10. A2 Review article, Literature review, Systematic review -
Consensus meta-analysis of genome-wide association studies for Alzheimer’s disease and related dementias
Lambert, Jean Charles; Ramirez, Alfredo; Ruiz, Agustín; Andreassen, Ole; Sims, Rebecca; Hiltunen, Mikko; Ingelsson, Martin; Sleegers, Kristel; Sánchez-Juan, Pascual; Ghidoni, Roberta; Frikke-Schmidt, Ruth; van Duijn, Cornelia; Tsolaki, Magda; Kehoe, Patrick G.; Fernandez, M. Victoria; Mather, Karen; Holstege, Henne; Jessen, Frank; Rossi, Giacomina; Masullo, Carlo; Bossù, Paola; Daniele, Antonio; Rainero, Innocenzo; Seripa, Davide; Spallazzi, Marco; Nacmias, Benedetta; Wagner, Michael; Borroni, B, 2026, Nature genetics, 58, 6, 1214–1225. A1 Journal article (refereed), original research -
Efficacy and Safety of Repeated Radiofrequency Thermocoagulation on Trigeminal Neuralgia Patients
Luikku, Antti J; Matikka, Sara; Heikkinen, Sami; Lipponen, Anssi; Luostarinen, Katja; Koivisto, Timo; Leinonen, Ville; Huttunen, Jukka; Jyrkkänen, Henna‐Kaisa, 2026, Pain practice, 26, 4, 1-8. A1 Journal article (refereed), original research -
Fibroblasts carrying intermediate C9orf72 hexanucleotide repeat expansions from iNPH patients show changes in energy metabolism but no cell pathologies
Hoffmann, Dorit; Korhonen, Ville; Rostalski, Hannah; Huber, Nadine; Heikkinen, Sami; Hietanen, Tomi; Wittrahm, Rebekka; Leskelä, Stina; Hartikainen, Päivi; Rauramaa, Tuomas; Solje, Eino; Portaankorva, Anne M; Hiltunen, Mikko; Leinonen, Ville; Haapasalo, Annakaisa, 2026, Biochimica et biophysica acta: molecular cell research, 1873, 6, 120177. A1 Journal article (refereed), original research -
GWAS meta-analysis of cerebrospinal fluid Alzheimer’s biomarkers reveals loci regulating lipids, brain volume and autophagy
Timsina, Jigyasha; Jiang, Chenyang; McCartney, Daniel L.; Tao, Feifei; Dalmasso, Maria Carolina; Najar, Jenna; Anastasi, Federica; Ohlei, Olena; Puerta Fuentes, Raquel; Yang, Chenyu; Bradley, Joseph; Western, Daniel; Ali, Muhammad; Wang, Ciyang; Yang, Chengran; Wu, Ying; Liu, Menghan; Budde, John; Williams, Julie; Mahoney, Rebecca; Castillo Morales, Atahualpa; Hohman, Timothy J.; Dumitrescu, Logan; Wang, Ting-Chen; Tesi, Niccolo’; Kern, Silke; Waern, Margda; Skoog, Ingmar; van Harten, Argonde; P, 2026, Nature communications, 17, 7385. A1 Journal article (refereed), original research -
Genetic variation shapes the chromatin accessibility landscape and transcriptional responses in mouse adipose tissue
Mononen, Juho; Taipale, Mari; Malinen, Marjo; Levonen, Anna-Liisa; Ruotsalainen, Anna-Kaisa; Norton, Luke; Heikkinen, Sami, 2026, PLoS genetics, 22, 1, e1011716. A1 Journal article (refereed), original research -
Protective PLCG2 variants associate with a delayed onset of Alzheimer’s disease among heterozygous APOE ε4 carriers
Jeskanen, Heli; Heikkinen, Sami; Kervinen, Inka; Lehtisalo, Jenni; Ngandu, Tiia; Willman, Roosa-Maria; Rosa, Jessica; Hoffmann, Dorit; Leinonen, Ville; Haapasalo, Annakaisa; Takalo, Mari; Martiskainen, Henna; Hiltunen, Mikko, 2026, Alzheimer's research and therapy, 18, 1, 53. A1 Journal article (refereed), original research -
The proportion of Alzheimer’s disease attributable to apolipoprotein E
Williams, Dylan M; Heikkinen, Sami; Hiltunen, Mikko; FinnGen; Davies, Neil M; Anderson, Emma L, 2026, npj dementia, 2, 1. A1 Journal article (refereed), original research -
A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations
Nagarajan, Pavithra; Winkler, Thomas W; Bentley, Amy R; Miller, Clint L; Kraja, Aldi T; Schwander, Karen; Lee, Songmi; Wang, Wenyi; Brown, Michael R; Morrison, John L; Giri, Ayush; O’Connell, Jeffrey R; Bartz, Traci M; de las Fuentes, Lisa; Gudmundsdottir, Valborg; Guo, Xiuqing; Harris, Sarah E; Huang, Zhijie; Kals, Mart; Kho, Minjung; Lefevre, Christophe; Luan, Jian’an; Lyytikäinen, Leo-Pekka; Mangino, Massimo; Milaneschi, Yuri; Palmer, Nicholette D; Rao, Varun; Rauramaa, Rainer; Shen, Botong;, 2025, Molecular psychiatry, 30, 8, 3660-3672. A1 Journal article (refereed), original research -
Discovery of Novel CSF Clearance Mechanism of Idiopathic Normal Pressure Hydrocephalus and Alzheimer's Disease
Lipponen, Anssi; Heikkinen, Sami; Räsänen, Joel; Macosko, Evan; Malm, Tarja; Hiltunen, Mikko; Leinonen, Ville, 2025, Alzheimer's & dementia. Poster