Sami Heikkinen
Research Director
Institute of Biomedicine, School of Medicine, Faculty of Health Sciences
[email protected] | +358 40 355 3393
Research groups
Publications
89/96 items-
A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations
Nagarajan, Pavithra; Winkler, Thomas W; Bentley, Amy R; Miller, Clint L; Kraja, Aldi T; Schwander, Karen; Lee, Songmi; Wang, Wenyi; Brown, Michael R; Morrison, John L; Giri, Ayush; O’Connell, Jeffrey R; Bartz, Traci M; de las Fuentes, Lisa; Gudmundsdottir, Valborg; Guo, Xiuqing; Harris, Sarah E; Huang, Zhijie; Kals, Mart; Kho, Minjung; Lefevre, Christophe; Luan, Jian’an; Lyytikäinen, Leo-Pekka; Mangino, Massimo; Milaneschi, Yuri; Palmer, Nicholette D; Rao, Varun; Rauramaa, Rainer; Shen, Botong;, 2025, Molecular psychiatry, 30, 8, 3660-3672. A1 Journal article (refereed), original research -
Discovery of Novel CSF Clearance Mechanism of Idiopathic Normal Pressure Hydrocephalus and Alzheimer's Disease
Lipponen, Anssi; Heikkinen, Sami; Räsänen, Joel; Macosko, Evan; Malm, Tarja; Hiltunen, Mikko; Leinonen, Ville, 2025, Alzheimer's & dementia. Poster -
Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage
Huber, Nadine; Hietanen, Tomi; Heikkinen, Sami; Shakirzyanova, Anastasia; Hoffmann, Dorit; Rostalski, Hannah; Dhingra, Ashutosh; Rodriguez-Nieto, Salvador; Kärkkäinen, Sari; Koskuvi, Marja; Korhonen, Eila; Hartikainen, Päivi; Pylkäs, Katri; Krüger, Johanna; Malm, Tarja; Takalo, Mari; Hiltunen, Mikko; Koistinaho, Jari; Portaankorva, Anne M; Solje, Eino; Haapasalo, Annakaisa, 2025, Molecular psychiatry, [Published: 26 September 2025], 1-17. A1 Journal article (refereed), original research -
GIGAVCID: A Genome‐Wide Meta‐Analysis of 1.1 Million Individuals Identifies Novel Genetic Loci for Vascular Cognitive Impairment
Fongang, Bernard; Ngouongo, Yannick Joel Wadop; Heikkinen, Sami; Yang, Qiong; Bis, Josh C.; Walters, Bragi; Stefansson, Kari; Gudmundsdottir, Valborg; Ninomiya, Toshiharu; Thomassen, Jesper Qvist; Jian, Xueqiu; Arora, Nikhil; Tabar, Mohsen Sharifi; Sargurupremraj, Muralidharan; Goss, Monica; Brumpton, Ben Michael; Winsvold, Bendik; Moreno, Elisa Amandine; Masaya, Kumamoto; Momozawa, Yukihide; Gudnason, Vilmundur; Launer, Lenore J J.; Lopez, Oscar L; Longstreth, William T; Fornage, Myriam; Dufoui, 2025, Alzheimer's & dementia. Poster -
Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants
Noordam, Raymond; Wang, Wenyi; Nagarajan, Pavithra; Wang, Heming; Brown, Michael R.; Bentley, Amy R.; Hui, Qin; Kraja, Aldi T.; Morrison, John L.; O'Connel, Jeffrey R.; Lee, Songmi; Schwander, Karen; Bartz, Traci M.; de las Fuentes, Lisa; Feitosa, Mary F.; Guo, Xiuqing; Hanfei, Xu; Harris, Sarah E.; Huang, Zhijie; Kals, Mart; Lefevre, Christophe; Mangino, Massimo; Milaneschi, Yuri; van der Most, Peter J.; Pacheco, Natasha L.; Palmer, Nicholette D.; Rao, Varun; Rauramaa, Rainer; Sun, Quan; Tabara, 2025, Atherosclerosis, 412, 120603. A1 Journal article (refereed), original research -
High expression of miR-7974 predicts poor prognosis and is associated with autophagy in estrogen receptor-positive breast cancer
Eneh, Stralina; Hartikainen, Jaana M.; Heikkinen, Sami; Sironen, Reijo; Tengström, Maria; Kosma, Veli-Matti; Ahuja, Saket; Mannermaa, Arto, 2025, PLoS ONE, 20, 4, e0322179. A1 Journal article (refereed), original research -
Low prevalence of CWH43 variants among Finnish and Norwegian idiopathic normal pressure hydrocephalus patients: a cohort-based observational study
Räsänen, Joel; Helisalmi, Seppo; Heikkinen, Sami; Raivo, Joose; Korhonen, Ville E.; Martiskainen, Henna; Junkkari, Antti; Grenier-Boley, Benjamin; Bellenguez, Céline; Oinas, Minna; Avellan, Cecilia; Frantzen, Janek; Kotkansalo, Anna; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; von und zu Fraunberg, Mikael; Lönnrot, Kimmo; Satopää, Jarno; Perola, Markus; Koivisto, Anne M.; Julkunen, Valtteri; Portaankorva, Anne M.; Mannermaa, Arto; Soininen, Hilkka; Jääskeläinen, Juha E.; Lambert, Jean-Cha, 2025, Fluids and barriers of the cns, 22, 1, 17. A1 Journal article (refereed), original research -
Machine learning in Alzheimer’s disease genetics
Bracher-Smith, Matthew; Melograna, Federico; Ulm, Brittany; Bellenguez, Céline; Grenier-Boley, Benjamin; Duroux, Diane; Nevado, Alejo J; Holmans, Peter; Tijms, Betty M; Hulsman, Marc; de Rojas, Itziar; Campos-Martin, Rafael; der Lee, Sven van; Castillo, Atahualpa; Küçükali, Fahri; Peters, Oliver; Schneider, Anja; Dichgans, Martin; Rujescu, Dan; Scherbaum, Norbert; Deckert, Jürgen; Riedel-Heller, Steffi; Hausner, Lucrezia; Molina-Porcel, Laura; Düzel, Emrah; Grimmer, Timo; Wiltfang, Jens; Heilman, 2025, Nature communications, 16, 1, 6726. A1 Journal article (refereed), original research -
Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease
Martiskainen, Henna; Willman, Roosa-Maria; Harju, Päivi; Heikkinen, Sami; Heiskanen, Mette; Müller, Stephan A.; Sinisalo, Rosa; Takalo, Mari; Mäkinen, Petra; Kuulasmaa, Teemu; Pekkala, Viivi; Galván del Rey, Ana; Juopperi, Sini-Pauliina; Jeskanen, Heli; Kervinen, Inka; Saastamoinen, Kirsi; Niiranen, Marja; Heikkinen, Sami V.; Kurki, Mitja I.; Marttila, Jarkko; Mäkinen, Petri I.; Rostalski, Hannah; Hietanen, Tomi; Ngandu, Tiia; Lehtisalo, Jenni; Bellenguez, Céline; Lambert, Jean-Charles; Haass, C, 2025, Molecular neurodegeneration, 20, 1, 50. A1 Journal article (refereed), original research -
Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids
Bentley, Amy R.; Brown, Michael R.; Musani, Solomon K.; Schwander, Karen L.; Winkler, Thomas W.; Sims, Mario; Kilpeläinen, Tuomas O.; Aschard, Hugues; Bartz, Traci M.; Bielak, Lawrence F.; Chai, Jin Fang; Chitrala, Kumaraswamy Naidu; Franceschini, Nora; Graff, Mariaelisa; Guo, Xiuqing; Hartwig, Fernando P.; Horimoto, Andrea R.V.R.; Lim, Elise; Liu, Yongmei; Manning, Alisa K.; Nolte, Ilja M.; Noordam, Raymond; Richard, Melissa A.; Smith, Albert V.; Sung, Yun Ju; Vojinovic, Dina; Wang, Rujia; Wang, 2025, Translational psychiatry, 15, 1, 207. A1 Journal article (refereed), original research