Sami Heikkinen
Research Director
Institute of Biomedicine, School of Medicine, Faculty of Health Sciences
[email protected] | +358 40 355 3393
Research groups
Publications
86/93 items-
A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations
Nagarajan, Pavithra; Winkler, Thomas W; Bentley, Amy R; Miller, Clint L; Kraja, Aldi T; Schwander, Karen; Lee, Songmi; Wang, Wenyi; Brown, Michael R; Morrison, John L; Giri, Ayush; O’Connell, Jeffrey R; Bartz, Traci M; de las Fuentes, Lisa; Gudmundsdottir, Valborg; Guo, Xiuqing; Harris, Sarah E; Huang, Zhijie; Kals, Mart; Kho, Minjung; Lefevre, Christophe; Luan, Jian’an; Lyytikäinen, Leo-Pekka; Mangino, Massimo; Milaneschi, Yuri; Palmer, Nicholette D; Rao, Varun; Rauramaa, Rainer; Shen, Botong;, 2025, Molecular psychiatry, 30, 8, 3660-3672. A1 Journal article (refereed), original research -
Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage
Huber, Nadine; Hietanen, Tomi; Heikkinen, Sami; Shakirzyanova, Anastasia; Hoffmann, Dorit; Rostalski, Hannah; Dhingra, Ashutosh; Rodriguez-Nieto, Salvador; Kärkkäinen, Sari; Koskuvi, Marja; Korhonen, Eila; Hartikainen, Päivi; Pylkäs, Katri; Krüger, Johanna; Malm, Tarja; Takalo, Mari; Hiltunen, Mikko; Koistinaho, Jari; Portaankorva, Anne M; Solje, Eino; Haapasalo, Annakaisa, 2025, Molecular psychiatry, [Published: 26 September 2025], 1-17. A1 Journal article (refereed), original research -
High expression of miR-7974 predicts poor prognosis and is associated with autophagy in estrogen receptor-positive breast cancer
Eneh, Stralina; Hartikainen, Jaana M.; Heikkinen, Sami; Sironen, Reijo; Tengström, Maria; Kosma, Veli-Matti; Ahuja, Saket; Mannermaa, Arto, 2025, PLoS ONE, 20, 4, e0322179. A1 Journal article (refereed), original research -
Low prevalence of CWH43 variants among Finnish and Norwegian idiopathic normal pressure hydrocephalus patients: a cohort-based observational study
Räsänen, Joel; Helisalmi, Seppo; Heikkinen, Sami; Raivo, Joose; Korhonen, Ville E.; Martiskainen, Henna; Junkkari, Antti; Grenier-Boley, Benjamin; Bellenguez, Céline; Oinas, Minna; Avellan, Cecilia; Frantzen, Janek; Kotkansalo, Anna; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; von und zu Fraunberg, Mikael; Lönnrot, Kimmo; Satopää, Jarno; Perola, Markus; Koivisto, Anne M.; Julkunen, Valtteri; Portaankorva, Anne M.; Mannermaa, Arto; Soininen, Hilkka; Jääskeläinen, Juha E.; Lambert, Jean-Cha, 2025, Fluids and barriers of the cns, 22, 1, 17. A1 Journal article (refereed), original research -
Machine learning in Alzheimer’s disease genetics
Bracher-Smith, Matthew; Melograna, Federico; Ulm, Brittany; Bellenguez, Céline; Grenier-Boley, Benjamin; Duroux, Diane; Nevado, Alejo J; Holmans, Peter; Tijms, Betty M; Hulsman, Marc; de Rojas, Itziar; Campos-Martin, Rafael; der Lee, Sven van; Castillo, Atahualpa; Küçükali, Fahri; Peters, Oliver; Schneider, Anja; Dichgans, Martin; Rujescu, Dan; Scherbaum, Norbert; Deckert, Jürgen; Riedel-Heller, Steffi; Hausner, Lucrezia; Molina-Porcel, Laura; Düzel, Emrah; Grimmer, Timo; Wiltfang, Jens; Heilman, 2025, Nature communications, 16, 1, 6726. A1 Journal article (refereed), original research -
Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease
Martiskainen, Henna; Willman, Roosa-Maria; Harju, Päivi; Heikkinen, Sami; Heiskanen, Mette; Müller, Stephan A.; Sinisalo, Rosa; Takalo, Mari; Mäkinen, Petra; Kuulasmaa, Teemu; Pekkala, Viivi; Galván del Rey, Ana; Juopperi, Sini-Pauliina; Jeskanen, Heli; Kervinen, Inka; Saastamoinen, Kirsi; Niiranen, Marja; Heikkinen, Sami V.; Kurki, Mitja I.; Marttila, Jarkko; Mäkinen, Petri I.; Rostalski, Hannah; Hietanen, Tomi; Ngandu, Tiia; Lehtisalo, Jenni; Bellenguez, Céline; Lambert, Jean-Charles; Haass, C, 2025, Molecular neurodegeneration, 20, 1, 50. A1 Journal article (refereed), original research -
Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids
Bentley, Amy R.; Brown, Michael R.; Musani, Solomon K.; Schwander, Karen L.; Winkler, Thomas W.; Sims, Mario; Kilpeläinen, Tuomas O.; Aschard, Hugues; Bartz, Traci M.; Bielak, Lawrence F.; Chai, Jin Fang; Chitrala, Kumaraswamy Naidu; Franceschini, Nora; Graff, Mariaelisa; Guo, Xiuqing; Hartwig, Fernando P.; Horimoto, Andrea R.V.R.; Lim, Elise; Liu, Yongmei; Manning, Alisa K.; Nolte, Ilja M.; Noordam, Raymond; Richard, Melissa A.; Smith, Albert V.; Sung, Yun Ju; Vojinovic, Dina; Wang, Rujia; Wang, 2025, Translational psychiatry, 15, 1, 207. A1 Journal article (refereed), original research -
Sociodemographic traits as early indicators of AD, FTD, and VaD up to 10 years before diagnosis
Kivisild, Ave; Rinnankoski, Iina; Aaltonen, Mikko; Aho, Kalle; Heikkinen, Sami; Lehtonen, Adolfina; Leppänen, Laura; Soppela, Helmi; Tervonen, Laura; Ervasti, Kaijus; Hartikainen, Päivi; Haapasalo, Annakaisa; Katisko, Kasper; Krüger, Johanna; Solje, Eino, 2025, Alzheimer's & dementia, 21, 9, 1-10. A1 Journal article (refereed), original research -
The Spatial Transcriptional Activity of Hepatic TCF7L2 Regulates Zonated Metabolic Pathways that Contribute to Liver Fibrosis
Ayala, Iriscilla; Hebbale, Skanda K.; Mononen, Juho; Brearley-Sholto, Madelaine C.; Shannon, Christopher E.; Valdez, Ivan; Fourcaudot, Marcel; Bakewell, Terry M.; Zagorska, Anna; Romero, Giovanna; Asmis, Mara; Musa, Fatima A.; Sily, Jonah T.; Smelter, Annie A.; Hinostroza, Edgar A.; Freitas Lima, Leandro C.; de Aguiar Vallim, Thomas Q.; Heikkinen, Sami; Norton, Luke, 2025, Nature communications, 16, 1, 1-19. A1 Journal article (refereed), original research -
The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions
Takalo, Mari; Jeskanen, Heli; Rolova, Taisia; Kervinen, Inka; Hellén, Marianna; Heikkinen, Sami; Koivisto, Hennariikka; Jokivarsi, Kimmo; Müller, Stephan A.; Koivumäki, Esa-Mikko; Mäkinen, Petra; Juopperi, Sini-Pauliina; Willman, Roosa-Maria; Sinisalo, Rosa; Hoffmann, Dorit; Jäntti, Henna; Peitz, Michael; Fließbach, Klaus; Kuulasmaa, Teemu; Natunen, Teemu; Kemppainen, Susanna; Poutiainen, Pekka; Leinonen, Ville; Malm, Tarja; Martiskainen, Henna; Ramirez, Alfredo; Haapasalo, Annakaisa; Lichtentha, 2025, Journal of neuroinflammation, 22, 1, 64. A1 Journal article (refereed), original research