Sohvi Ohtonen
Visiting Researcher
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
Research groups
Publications
11/11 items-
Microglia from patients with multiple sclerosis display a cell-autonomous immune activation state
Hyvärinen, Tanja; Tilvis, Johanna; Giudice, Luca; Tujula, Iisa; Nylund, Marjo; Ohtonen, Sohvi; Scoyni, Flavia; Jäntti, Henna; Virtanen, Lassi; Pihlava, Sara; Kattelus, Roosa; Skottman, Heli; Narkilahti, Susanna; Airas, Laura; Malm, Tarja; Hagman, Sanna, 2025, Journal of neuroinflammation, 22, 1, 255. A1 Journal article (refereed), original research -
Mitochondrial and energy metabolism dysfunctions are hallmarks of TDP-43G376D fibroblasts from members of an Amyotrophic Lateral Sclerosis family
Perciballi, Elisa; Bovio, Federica; Ferro, Sara; Forcella, Matilde; Rosati, Jessica; Carletti, Rose Mary; D’Anzi, Angela; Gelati, Maurizio; La Bella, Vincenzo; Innocenti, Metello; Spataro, Rossella; Pecoraro, Martina; Lombardi, Ivan; Vulcano, Edvige; Ruotolo, Giorgia; Mercurio, Sara; Sabatelli, Mario; Lattante, Serena; Malm, Tarja; Ohtonen, Sohvi; Vescovi, Angelo Luigi; Fusi, Paola; Ferrari, Daniela, 2025, Cell death and disease, 16, 1, 1-10. A1 Journal article (refereed), original research -
Traffic-related diesel pollution particles impair the lysosomal functions of human iPSC-derived microglia
Ohtonen, Sohvi; Jäntti, Henna; Giudice, Luca; Mohamed, Ahmed; Shakirzyanova, Anastasia; Závodná, Táňa; Belevich, Ilya; Yan, Hong; Sabogal-Guáqueta, Angélica María; Saveleva, Liudmila; Väänänen, Mari-Anna; Rillo-Albert, Ashley; Perciballi, Elisa; Ferrari, Daniela; Tervo, Minna-Mari; Gómez-Budia, Mireia; Krejčík, Zdeněk; Aakko-Saksa, Päivi; Koistinaho, Jari; Lehtonen, Šárka; Kanninen, Katja M.; Topinka, Jan; Jokitalo, Eija; Sierra, Alejandra; Schmidt, Martina; Dolga, Amalia M.; Jalava, Pasi I.; Ko, 2025, Environment international, 199, 109467. A1 Journal article (refereed), original research -
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease
Xia, Zengjie; Prescott, Emily E; Urbanek, Agnieszka; Wareing, Hollie E; King, Marianne C; Olerinyova, Anna; Dakin, Helen; Leah, Tom; Barnes, Katy A; Matuszyk, Martyna M; Dimou, Eleni; Hidari, Eric; Zhang, Yu P; Lam, Jeff Y. L; Danial, John SH; Strickland, Michael R; Jiang, Hong; Thornton, Peter; Crowther, Damian C. Ohtonen, Sohvi; Gómez-Budia, Mireia; Bell, Simon M; Ferraiuolo, Laura; Mortiboys, Heather; Higginbottom, Adrian; Wharton, Stephen B; Holtzman, David M; Malm, Tarja; Ranasinghe, Rohan, 2024, Nature communications, 15, 1, 4695. A1 Journal article (refereed), original research -
Neurodegeneration linked genetic and environmental factors in in vitro human microglia model: focus on APOE, LRRK2 and traffic-related air pollution
Ohtonen, Sohvi, 2024, Publications of the University of Eastern Finland. Dissertations in Health Sciences. G5 Doctoral dissertation (article) -
Particulate matter from car exhaust alters function of human iPSC-derived microglia
Jäntti, Henna; Jonk, Steffi; Gómez Budia, Mireia; Ohtonen, Sohvi; Fagerlund, Ilkka; Fazaludeen, Mohammad Feroze; Aakko-Saksa, Päivi; Pebay, Alice; Lehtonen, Šárka; Koistinaho, Jari; Kanninen, Katja M; Jalava, Pasi I; Malm, Tarja; Korhonen, Paula, 2024, Particle and fibre toxicology, 21, 1, 6. A1 Journal article (refereed), original research -
Uptake of alpha‐synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia
Niskanen, Jonna; Peltonen, Sanni; Ohtonen, Sohvi; Fazaludeen, Mohammad Feroze; Luk, Kelvin C; Giudice, Luca; Koistinaho, Jari; Malm, Tarja; Goldsteins, Gundars; Albert, Katrina; Lehtonen, Šárka, 2024, Glia, 2025; 73, 1, 159-174. A1 Journal article (refereed), original research -
Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson’s disease related transcriptional profile and function
Ohtonen, Sohvi; Giudice, Luca; Jäntti, Henna; Fazaludeen, Mohammad Feroze; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Välimäki, Nelli-Noora; Niskanen, Jonna; Korvenlaita, Nea; Fagerlund, Ilkka; Koistinaho, Jari; Amiry-Moghaddam, Mahmood; Savchenko, Ekaterina; Roybon, Laurent; Lehtonen, Šárka; Korhonen, Paula; Malm, Tarja, 2023, Scientific reports, 13, 1, 22118. A1 Journal article (refereed), original research -
Microglial amyloid beta clearance is driven by PIEZO1 channels
Jäntti, Henna; Sitnikova, Valeriia; Ishchenko, Yevheniia; Shakirzyanova, Anastasia; Giudice, Luca; Ugidos, Irene F; Gómez-Budia, Mireia; Korvenlaita, Nea; Ohtonen, Sohvi; Belaya, Irina; Fazaludeen, Feroze; Mikhailov, Nikita; Gotkiewicz, Maria; Ketola, Kirsi; Lehtonen, Šárka; Koistinaho, Jari; Kanninen, Katja M; Hernández, Damian; Pébay, Alice; Giugno, Rosalba; Korhonen, Paula; Giniatullin, Rashid; Malm, Tarja, 2022, Journal of neuroinflammation, 19, 1, 147. A1 Journal article (refereed), original research -
Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids
Fagerlund, Ilkka; Dougalis, Antonios; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Pelkonen, Anssi; Konttinen, Henna; Ohtonen, Sohvi; Fazaludeen, Mohammad Feroze; Koskuvi, Marja; Kuusisto, Johanna; Hernández, Damián; Pebay, Alice; Koistinaho, Jari; Rauramaa, Tuomas; Lehtonen, ¦árka; Korhonen, Paula; Malm, Tarja, 2021, Cells, 2022; 11, 1, 124. A1 Journal article (refereed), original research