Sohvi Ohtonen - UEFConnect

Refine your search

Information Publications

Research groups

Neuroinflammation research group 01.01.2017 -

Keywords

air pollution iPSC microglia neuroinflammation stem cells

Publications

9/9 items

Mitochondrial and energy metabolism dysfunctions are hallmarks of TDP-43G376D fibroblasts from members of an Amyotrophic Lateral Sclerosis family
Perciballi, Elisa; Bovio, Federica; Ferro, Sara; Forcella, Matilde; Rosati, Jessica; Carletti, Rose Mary; D’Anzi, Angela; Gelati, Maurizio; La Bella, Vincenzo; Innocenti, Metello; Spataro, Rossella; Pecoraro, Martina; Lombardi, Ivan; Vulcano, Edvige; Ruotolo, Giorgia; Mercurio, Sara; Sabatelli, Mario; Lattante, Serena; Malm, Tarja; Ohtonen, Sohvi; Vescovi, Angelo Luigi; Fusi, Paola; Ferrari, Daniela. 2025. Cell death and disease. 16: 1-10 A1 Journal article (refereed), original research
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease
Xia, Zengjie; Prescott, Emily E; Urbanek, Agnieszka; Wareing, Hollie E; King, Marianne C; Olerinyova, Anna; Dakin, Helen; Leah, Tom; Barnes, Katy A; Matuszyk, Martyna M; Dimou, Eleni; Hidari, Eric; Zhang, Yu P; Lam, Jeff Y. L; Danial, John SH; Strickland, Michael R; Jiang, Hong; Thornton, Peter; Crowther, Damian C. Ohtonen, Sohvi; Gómez-Budia, Mireia; Bell, Simon M; Ferraiuolo, Laura; Mortiboys, Heather; Higginbottom, Adrian; Wharton, Stephen B; Holtzman, David M; Malm, Tarja; Ranasinghe, Rohan . 2024. Nature communications. 15: . 4695 A1 Journal article (refereed), original research
Neurodegeneration linked genetic and environmental factors in in vitro human microglia model: focus on APOE, LRRK2 and traffic-related air pollution
Ohtonen, Sohvi. 2024. Publications of the University of Eastern Finland. Dissertations in Health Sciences G5 Doctoral dissertation (article)
Particulate matter from car exhaust alters function of human iPSC-derived microglia
Jäntti, Henna; Jonk, Steffi; Gómez Budia, Mireia; Ohtonen, Sohvi; Fagerlund, Ilkka; Fazaludeen, Mohammad Feroze; Aakko-Saksa, Päivi; Pebay, Alice; Lehtonen, Šárka; Koistinaho, Jari; Kanninen, Katja M; Jalava, Pasi I; Malm, Tarja; Korhonen, Paula. 2024. Particle and fibre toxicology. 21: . 6 A1 Journal article (refereed), original research
Uptake of alpha‐synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia
Niskanen, Jonna; Peltonen, Sanni; Ohtonen, Sohvi; Fazaludeen, Mohammad Feroze; Luk, Kelvin C; Giudice, Luca; Koistinaho, Jari; Malm, Tarja; Goldsteins, Gundars; Albert, Katrina; Lehtonen, Šárka. 2024. Glia. 2025; 73: 159-174 A1 Journal article (refereed), original research
Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson’s disease related transcriptional profile and function
Ohtonen, Sohvi; Giudice, Luca; Jäntti, Henna; Fazaludeen, Mohammad Feroze; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Välimäki, Nelli-Noora; Niskanen, Jonna; Korvenlaita, Nea; Fagerlund, Ilkka; Koistinaho, Jari; Amiry-Moghaddam, Mahmood; Savchenko, Ekaterina; Roybon, Laurent; Lehtonen, Šárka; Korhonen, Paula; Malm, Tarja. 2023. Scientific reports. 13: . 22118 A1 Journal article (refereed), original research
Microglial amyloid beta clearance is driven by PIEZO1 channels
Jäntti, Henna; Sitnikova, Valeriia; Ishchenko, Yevheniia; Shakirzyanova, Anastasia; Giudice, Luca; Ugidos, Irene F; Gómez-Budia, Mireia; Korvenlaita, Nea; Ohtonen, Sohvi; Belaya, Irina; Fazaludeen, Feroze; Mikhailov, Nikita; Gotkiewicz, Maria; Ketola, Kirsi; Lehtonen, Šárka; Koistinaho, Jari; Kanninen, Katja M; Hernández, Damian; Pébay, Alice; Giugno, Rosalba; Korhonen, Paula; Giniatullin, Rashid; Malm, Tarja. 2022. Journal of neuroinflammation. 19: . 147 A1 Journal article (refereed), original research
Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids
Fagerlund, Ilkka; Dougalis, Antonios; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Pelkonen, Anssi; Konttinen, Henna; Ohtonen, Sohvi; Fazaludeen, Mohammad Feroze; Koskuvi, Marja; Kuusisto, Johanna; Hernández, Damián; Pebay, Alice; Koistinaho, Jari; Rauramaa, Tuomas; Lehtonen, ¦árka; Korhonen, Paula; Malm, Tarja. 2021. Cells. 2022; 11: 124 A1 Journal article (refereed), original research
PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia
Konttinen, H; Cabral-da-Silva, MEC; Ohtonen, S; Wojciechowski, S; Shakirzyanova, A; Caligola, S; Giugno, R; Ishchenko, Y; Hernández, D; Fazaludeen, MF; Eamen, S; Budia, MG; Fagerlund, I; Scoyni, F; Korhonen, P; Huber, N; Haapasalo, A; Hewitt, AW; Vickers, J; Smith, GC; et al.. 2019. Stem cell reports. 13: 669-683 A1 Journal article (refereed), original research