Svetlana Laidinen

Capturing Acute and Subchronic Myocardial Infarct by MRI Rotating Frame Relaxation Times in Mice In and Ex Vivo

Ylä-Herttuala, Elias; Laakso, Hanne; Khan, Muhammad Arsalan; Laidinen, Svetlana; Heikura, Tommi; Ylä-Herttuala, Seppo; Liimatainen, Timo. 2025. Nmr in biomedicine. 38: A1 Journal article (refereed), original research

Myocardial infarction activates the 9p21.3 orthologous locus expression, but its absence does not alter cardiac pathophysiology in ischemia

Kettunen, Sanna; Slita, Anna; Suoranta, Tuisku; Räty, Iida; Laidinen, Svetlana; Ylä‐Herttuala, Elias; Ruotsalainen, Anna‐Kaisa; Ylä‐Herttuala, Seppo. 2025. Physiological reports. 13: 1-15 A1 Journal article (refereed), original research

Ex vivo imaging of subacute myocardial infarction with ultra-short echo time 3D quantitative T1- and T1ρ-mapping magnetic resonance imaging in mice

Räty, Iida; Aarnio, Antti; Nissi, Mikko J; Kettunen, Sanna; Ruotsalainen, Anna-Kaisa; Laidinen, Svetlana; Ylä-Herttuala, Seppo; Ylä-Herttuala, Elias. 2024. European heart journal : imaging methods and practice. 3: 1-10 A1 Journal article (refereed), original research

ErbB signalling is a potential therapeutic target for vascular lesions with fibrous component

Jauhiainen, Suvi; Ilmonen, Henna; Vuola, Pia; Rasinkangas, Heta; Pulkkinen, Heidi H; Keränen, Sara; Kiema, Miika; Liikkanen, Jade J; Laham Karam, Nihay; Laidinen, Svetlana; Beter, Mustafa; Aavik, Einari; Lappalainen, Kimmo; Lohi, Jouko; Aronniemi, Johanna; Örd, Tiit; Kaikkonen, Minna U; Salminen, Päivi; Tukiainen, Erkki; Ylä-Herttuala, Seppo; Laakkonen, Johanna P. 2023. eLife. 12: A1 Journal article (refereed), original research

Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models

Freitag, Tobias L; Fagerlund, Riku; Karam, Nihay Laham; Leppänen, Veli-Matti; Ugurlu, Hasan; Kant, Ravi; Mäkinen, Petri; Tawfek, Ahmed; Kumar, Sawan; Strandin, Tomas; Leskinen, Katarzyna; Hepojoki, Jussi; Kesti, Tapio; Kareinen, Lauri; Kuivanen, Suvi; Koivulehto, Emma; Sormunen, Aino; Laidinen, Svetlana; Khattab, Ayman; Saavalainen, Päivi; Meri, Seppo; Kipar, Anja; Sironen, Tarja; Vapalahti, Olli; Alitalo, Kari; Ylä-Herttuala, Seppo; Saksela, Kalle. 2023. Vaccine. 41: 3233-3246 A1 Journal article (refereed), original research

Lymphatic insufficiency leads to distinct myocardial infarct content assessed by magnetic resonance TRAFFn, T1ρ and T2 relaxation times

Ylä-Herttuala, Elias; Vuorio, Taina; Kettunen, Sanna; Laidinen, Svetlana; Ylä-Herttuala, Seppo; Liimatainen, Timo. 2023. Scientific reports. 13: . 1579 A1 Journal article (refereed), original research

Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction

Vuorio, Taina; Ylä-Herttuala, Elias; Laakkonen, Johanna P; Laidinen, Svetlana; Liimatainen, Timo; Ylä-Herttuala, Seppo. 2018. Scientific reports. 8: 16709 A1 Journal article (refereed), original research

Peroxisome Proliferator-activated Receptor-gamma Coactivator 1 alfa1 Induces a Cardiac Excitation-contraction Coupling Phenotype Without Metabolic Remodelling

Mutikainen Maija, Tuomainen Tomi, Naumenko Nikolay, Huusko Jenni, Smirin Boris, Laidinen S, Kokki K, Hynynen H, Ylä-Herttuala S, Heinäniemi M, Ruas JL, Tavi P. 2016. Journal of physiology: london. 594: 7049-7071 A1 Journal article (refereed), original research

Mouse ECG findings in aging, with conduction system affecting drugs and in cardiac pathologies: Development and validation of ECG analysis algorithm in mice

Merentie M, Lipponen JA, Hedman M, Hedman A, Hartikainen J, Huusko J, Lottonen-Raikaslehto L, Parviainen V, Laidinen S, Karjalainen PA, Ylä-Herttuala S. 2015. Psychological reports. 3: e12639 A1 Journal article (refereed), original research

Epigenetic upregulation of endogenous VEGF-A reduces myocardial infarct size in mice

Turunen Mikko P, Husso Tiia, Musthafa Haja, Laidinen Svetlana, Dragneva Galina, Laham-Karam Nihay, Honkanen Sanna, Paakinaho Anne, Laakkonen Johanna P, Gao Erhe, Vihinen-Ranta Maija, Liimatainen Timo, Ylä-Herttuala Seppo. 2014. PLoS ONE. 2014 Feb 26;9(2):e89979: e89979 A1 Journal article (refereed), original research

Hypoxia-inducible factor 1-induced G protein-coupled receptor 35 expression is an early marker of progressive cardiac remodelling

Ronkainen Veli-Pekka, Tuomainen Tomi, Huusko Jenni, Laidinen Svetlana, Malinen Marjo, Palvimo Jorma J, Ylä-Herttuala Seppo, Vuolteenaho Olli, Tavi Pasi. 2014. Cardiovascular research. 2014 Jan 1;101(1): 69-77 A1 Journal article (refereed), original research

LDLR(-/-)ApoB(100/100) mice with insulin-like growth factor II overexpression reveal a novel form of retinopathy with photoreceptor atrophy and altered morphology of the retina

Kinnunen K, Heinonen SE, Kalesnykas G, Laidinen S, Uusitalo-Järvinen H, Uusitalo H, Ylä-Herttuala S. 2013. Molecular vision. 19: 1723-1733 A1 Journal article (refereed), original research

Antiangiogenic gene therapy with soluble VEGF-receptors -1, -2 and -3 together with paclitaxel prolongs survival of mice with human ovarian carcinoma

Sopo M, Anttila M, Sallinen H, Tuppurainen L, Laurema A, Laidinen S, Hamalainen K, Tuunanen P, Koponen JK, Kosma VM, Heinonen S, Alitalo K, Yla-Herttuala S. 2012. International journal of cancer. 131: 234-2401 A1 Journal article (refereed), original research

Capillary enlargement, not sprouting angiogenesis, determines beneficial therapeutic effects and side effects of angiogenic gene therapy

Korpisalo P, Hytönen JP, Laitinen JT, Laidinen S, Parviainen H, Karvinen H, Siponen J, Marjomäki V, Vajanto I, Rissanen TT, Ylä-Herttuala S.. 2011. European heart journal. 32: 1664-1672 A1 Journal article (refereed), original research

Lymphatic vasculature is increased in heart valves, ischaemic and inflamed hearts and in cholesterol-rich and calcified atherosclerotic lesions

Kholová Ivana, Dragneva Galina, Cermáková Petra, Laidinen Svetlana, Kaskenpää Nina, Hazes Thierry, Cermáková Eva, Steiner Ivo, Ylä-Herttuala Seppo. 2011. European journal of clinical investigation. 41: 487-497 A1 Journal article (refereed), original research

Baculovirus is an efficient vector for the transduction of the eye: comparison of baculovirus- and adenovirus-mediated intravitreal vascular endothelial growth factor D gene transfer in the rabbit eye

Kinnunen K, Kalesnykas G, Mähönen AJ, Laidinen S, Holma L, Heikura T, Airenne K, Uusitalo H, Ylä-Herttuala S, Kinnunen K, Kalesnykas G. 2009. Journal of gene medicine. 11: 382-389 A1 Journal article (refereed), original research

Differences in retinal neovascular tissue and vitreous humour in patients with type 1 and type 2 diabetes

Kinnunen K, Puustjärvi T, Teräsvirta M, Nurmenniemi P, Heikura T, Laidinen S, Paavonen T, Uusitalo H, Ylä-Herttuala S, Kinnunen K. 2009. British journal of ophthalmology. 93: 1109-1115 A1 Journal article (refereed), original research

Intravitreal adenoviral 15-lipoxygenase- 1 gene transfer prevents vascular endothelial growth factor A-induced neovascularization in rabbit eyes

Viita H, Kinnunen K, Eriksson E, Lähteenvuo J, Babu M, Kalesnykas G, Heikura T, Laidinen S, Takalo T, Ylä-Herttuala S. 2009. Human gene therapy. 20: 1679-1686 A1 Journal article (refereed), original research

15-lipoxygenase-1 prevents vascular endothelial growth factor A- and placental growth factor-induced angiogenic effects in rabbit skeletal muscles via reduction in growth factor mRNA levels, NO bioactivity, and downregulation of VEGF receptor 2 expression

Viita H, Markkanen J, Eriksson E, Nurminen M, Kinnunen K, Babu M, Heikura T, Turpeinen S, Laidinen S, Takalo T, Ylä-Herttuala S. 2008. Circulation research. 102: 177-184 A1 Journal article (refereed), original research

High-resolution ultrasound perfusion imaging of therapeutic angiogenesis

Rissanen TT, Korpisalo P, Karvinen H, Liimatainen T, Laidinen S, Gröhn OH, Ylä-Herttuala S. 2008. JACC : cardiovascular imaging. 1: 83 - 91 A1 Journal article (refereed), original research

Therapeutic angiogenesis with placental growth factor improves exercise tolerance of ischaemic rabbit hindlimbs

Korpisalo P, Rissanen TT, Bengtsson T, Liimatainen T, Laidinen S, Karvinen H, Markkanen JE, Gröhn OH, Ylä-Herttuala S. 2008. Cardiovascular research. 80: 263-270 A1 Journal article (refereed), original research

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Publications

Capturing Acute and Subchronic Myocardial Infarct by MRI Rotating Frame Relaxation Times in Mice In and Ex Vivo

Myocardial infarction activates the 9p21.3 orthologous locus expression, but its absence does not alter cardiac pathophysiology in ischemia

Ex vivo imaging of subacute myocardial infarction with ultra-short echo time 3D quantitative T1- and T1ρ-mapping magnetic resonance imaging in mice

ErbB signalling is a potential therapeutic target for vascular lesions with fibrous component

Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models

Lymphatic insufficiency leads to distinct myocardial infarct content assessed by magnetic resonance TRAFFn, T1ρ and T2 relaxation times

Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction

Peroxisome Proliferator-activated Receptor-gamma Coactivator 1 alfa1 Induces a Cardiac Excitation-contraction Coupling Phenotype Without Metabolic Remodelling

Mouse ECG findings in aging, with conduction system affecting drugs and in cardiac pathologies: Development and validation of ECG analysis algorithm in mice

Epigenetic upregulation of endogenous VEGF-A reduces myocardial infarct size in mice

Hypoxia-inducible factor 1-induced G protein-coupled receptor 35 expression is an early marker of progressive cardiac remodelling

LDLR(-/-)ApoB(100/100) mice with insulin-like growth factor II overexpression reveal a novel form of retinopathy with photoreceptor atrophy and altered morphology of the retina

Antiangiogenic gene therapy with soluble VEGF-receptors -1, -2 and -3 together with paclitaxel prolongs survival of mice with human ovarian carcinoma

Capillary enlargement, not sprouting angiogenesis, determines beneficial therapeutic effects and side effects of angiogenic gene therapy

Lymphatic vasculature is increased in heart valves, ischaemic and inflamed hearts and in cholesterol-rich and calcified atherosclerotic lesions

Baculovirus is an efficient vector for the transduction of the eye: comparison of baculovirus- and adenovirus-mediated intravitreal vascular endothelial growth factor D gene transfer in the rabbit eye

Differences in retinal neovascular tissue and vitreous humour in patients with type 1 and type 2 diabetes

Intravitreal adenoviral 15-lipoxygenase- 1 gene transfer prevents vascular endothelial growth factor A-induced neovascularization in rabbit eyes

15-lipoxygenase-1 prevents vascular endothelial growth factor A- and placental growth factor-induced angiogenic effects in rabbit skeletal muscles via reduction in growth factor mRNA levels, NO bioactivity, and downregulation of VEGF receptor 2 expression

High-resolution ultrasound perfusion imaging of therapeutic angiogenesis

Therapeutic angiogenesis with placental growth factor improves exercise tolerance of ischaemic rabbit hindlimbs