TATU PANTSAR

Contact info

Research groups - UEF

• 
  Molecular Modeling and Drug Design Research Group

Publications

• Andreev, Stanislav; Pantsar, Tatu; Tesch, Roberta; Kahlke, Niclas; El-Gokha, Ahmed; Ansideri, Francesco; Grätz, Lukas; Romasco, Jenny; Sita, Giulia; Geibel, Christian; Lämmerhofer, Michael; Tarozzi, Andrea; Knapp, Stefan; Laufer, Stefan A.; Koch, Pierre. 2021. Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3ß Inhibitors Journal of medicinal chemistry 2022; 65 2: 1283-1301. 2021
• Mustonen, Enni-Kaisa; Lee, Serene M L; Niess, Hanno; Schwab, Matthias; Pantsar, Tatu; Burk, Oliver. 2021. Identification and characterization of novel splice variants of human farnesoid X receptor Archives of biochemistry and biophysics 705: 108893. 2021
• Salo-Ahen, Outi MH; Alanko, Ida; Bhadane, Rajendra; Bonvin, Alexandre MJJ; Honorato, Rodrigo Vargas; Hossain, Shakhawath; Juffer, André H; Kabedev, Aleksei; Lahtela-Kakkonen, Maija; Larsen, Anders Støttrup; Lescrinier, Eveline; Marimuthu, Parthiban; Mirza, Muhammad Usman; Mustafa, Ghulam; Nunes-Alves, Ariane; Pantsar, Tatu; Saadabadi, Atefeh; Singaravelu, Kalaimathy; Vanmeert, Michiel. 2021. Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development Processes 9 1: 71. 2021
• Andreev, Stanislav; Pantsar, Tatu; El-Gokha, Ahmed; Ansideri, Francesco; Kudolo, Mark; Anton, Débora Bublitz; Sita, Giulia; Romasco, Jenny; Geibel, Christian; Lämmerhofer, Michael; Goettert, Márcia Ines; Tarozzi, Andrea; Laufer, Stefan A; Koch, Pierre. 2020. Discovery and Evaluation of Enantiopure 9 H-pyrimido[4,5- b]indoles as Nanomolar GSK-3ß Inhibitors with Improved Metabolic Stabili International journal of molecular sciences 21 21: 7823. 2020
• Kircher, Theresa; Pantsar, Tatu; Oder, Andreas; Peter von Kries, Jens; Juchum, Michael; Pfaffenrot, Bent; Kloevekorn, Philip; Albrecht, Wolfgang; Selig, Roland; Laufer, Stefan. 2020. Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4 European journal of medicinal chemistry 2021; 209: 112901. 2020
• Pantsar, Tatu. 2020. KRAS(G12C)-AMG 510 interaction dynamics revealed by all-atom molecular dynamics simulations Scientific reports 10: 11992. 2020
• Pedreira, Julia G B; Nahidino, Philipp; Kudolo, Mark; Pantsar, Tatu; Berger, Benedict-Tilman; Forster, Michael; Knapp, Stefan; Laufer, Stefan; Barreiro, Eliezer J. 2020. Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38[alpha] MAP Kinase Inhibitors Journal of medicinal chemistry 63 13: 7347-7354. 2020
• Shevchenko, Ekaterina; Poso, Antti; Pantsar, Tatu. 2020. The autoinhibited state of MKK4: Phosphorylation, putative dimerization and R134W mutant studied by molecular dynamics simulations Computational and Structural Biotechnology Journal 18: 2687-2698. 2020
• Pantsar, Tatu. 2019. The current understanding of KRAS protein structure and dynamics Computational and Structural Biotechnology Journal 2020; 18: 189-198. 2019
• Heider, Fabian; Ansideri, Francesco; Tesch, Roberta; Pantsar, Tatu; Haun, Urs; Döring, Eva; Kudolo, Mark; Poso, Antti; Albrecht, Wolfgang; Laufer, Stefan A; Koch, Pierre. 2019. Pyridinylimidazoles as dual glycogen synthase kinase 3β/p38α mitogen-activated protein kinase inhibitors European journal of medicinal chemistry 175: 309-329. 2019
• Heider, F; Pantsar, T; Kudolo, M; Ansideri, F; De Simone, A; Pruccoli, L; Schneider, T; Goettert, MI; Tarozzi, A; Andrisano, V; Laufer, SA; Koch, P. 2019. Pyridinylimidazoles as GSK3ß Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks Acs medicinal chemistry letters 10 10: 1407-1414. 2019
• Andreev, S; Pantsar, T; Ansideri, F; Kudolo, M; Forster, M; Schollmeyer, D; Laufer, SA; Koch, P. 2019. Design, Synthesis and Biological Evaluation of 7-Chloro-9H-pyrimido[4,5-b]indole-based Glycogen Synthase Kinase-3ß Inhibitors Molecules 24 12: 2331. 2019
• Meng-Lund, Helena; Kasten, Georgia; Jensen, Katrina Tarp; Poso, Antti; Pantsar, Tatu; Rades, Thomas; Rantanen, Jukka; Grohganz, Holger. 2018. The use of molecular descriptors in the development of co-amorphous formulations. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 119: 31-38. 2018
• Pantsar, Tatu. 2018. Designing effective lead molecules against solid tumors with inadequate treatment options, the efficacy problem. Itä-Suomen yliopisto. Publications of the University of Eastern Finland. Dissertations in Health Sciences 456. 2018
• Pantsar, Tatu; Poso, Antti. 2018. Binding Affinity via Docking: Fact and Fiction Molecules 23 8: 1899. 2018
• Pantsar, Tatu; Rissanen, Sami; Dauch, Daniel; Laitinen, Tuomo; Vattulainen, Ilpo; Poso, Antti. 2018. Assessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling PLOS COMPUTATIONAL BIOLOGY 14 9: e1006458. 2018
• Pantsar T, Singha P, Nevalainen TJ, Koshevoy I, Leppänen J, Poso A, Niskanen JMA, Pasonen-Seppänen S, Savinainen JR, Laitinen T, Laitinen JT. 2017. Design, Synthesis, and Biological Evaluation of 2,4-Dihydropyrano[2,3-c]pyrazole Derivatives as Autotaxin Inhibitors. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 107: 97-111. 2017
• Dauch Daniel, Rudalska Ramona, Cossa Giacomo, Nault Jean-Charles, Kang Tae-Won, Wuestefeld Torsten, Hohmeyer Anja, Imbeaud Sandrine, Yevsa Tetyana, Hoenicke Lisa, Pantsar Tatu, Bozko Przemyslaw, Malek Nisar P, Longerich Thomas, Laufer Stefan, Poso Antti, Zucman-Rossi Jessica, Eilers Martin, Zender Lars. 2016. A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer. NATURE MEDICINE 22 7: 744-753. 2016
• Savinainen Juha R, Kansanen Emilia, Pantsar Tatu, Navia-Paldanius Dina, Parkkari Teija, Lehtonen Marko, Laitinen Tuomo, Nevalainen Tapio, Poso Antti, Levonen Anna-Liisa, Laitinen Jarmo T. 2014. Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL). MOLECULAR PHARMACOLOGY Epub ahead of print: -. 2014
• Laitinen Tuomo, Navia-Paldanius Dina, Rytilahti Roosa, Marjamaa Joona J, Karizkova Julie, Parkkari Teija, Pantsar Tatu, Poso Antti, Laitinen Jarmo T, Savinainen Juha R. 2013. Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency. MOLECULAR PHARMACOLOGY 2014:85: 510-519. 2013