
Tatu Pantsar
Yliopistotutkija
Farmasian laitos, Terveystieteiden tiedekunta
[email protected] | 050 388 1062
Tutkimusryhmät
Julkaisut
31/31 kappaletta-
Binding modes of the KRAS(G12C) inhibitors GDC-6036 and LY3537982 revealed by all atom molecular dynamics simulations
Leini, Renne; Kapp, Jonas; Kopra, Kari; Pantsar, Tatu. 2025. Scientific reports. 15: . 24843 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
First-in-class ultralong-target-residence-time p38α inhibitors as a mitosis-targeted therapy for colorectal cancer
Rudalska, Ramona; Harbig, Jule; Forster, Michael; Woelffing, Pascal; Esposito, Aylin; Kudolo, Mark; Botezatu, Adelina; Haller, Vanessa; Janssen, Nicole; Holzmayer, Samuel; Nahidino, Philipp; Trompak, Omelyan; Pantsar, Tatu; Kronenberger, Thales; Yurttas, Can; Rist, Elke; Weber, Alexander N R; Dahlke, Marc H; Ott, German; Koenigsrainer, Alfred; Rothbauer, Ulrich; Maerklin, Melanie; Muerdter, Thomas; Schwab, Matthias; Singer, Stephan; Zender, Lars; Laufer, Stefan; Dauch, Daniel. 2025. Nature cancer. 6: 259-277 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2
Karim, Marwah; Mishra, Manjari; Lo, Chieh Wen; Saul, Sirle; Cagirici, Halise Busra; Gourdelier, Manon; Ghita, Luca; Ojha, Amrita; Tran, Do Hoang Nhu; Agrawal, Aditi; McGraw, Connor; East, Michael P; Gammeltoft, Karen Anbro; Sahoo, Malaya Kumar; Mooney, Nancie A; Johnson, Gary L; Das, Soumita; Leyssen, Pieter; Neyts, Johan; Chiu, Winston; Cohen, Courtney A; Bukh, Jens; Gottwein, Judith; Dye, John M; Neff, Norma; Jackson, Peter K; Pinsky, Benjamin A; Laitinen, Tuomo; Pantsar, Tatu; Poso, Antti; Za. 2025. Nature communications. 16: . 6397 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96
Mahran, Randa; Kapp, Jonas N; Valtonen, Salla; Champagne, Allison; Ning, Jinying; Gillette, William; Stephen, Andrew G; Hao, Feng; Plückthun, Andreas; Härmä, Harri; Pantsar, Tatu; Kopra, Kari. 2024. Acs chemical biology. 19: 2152-2164 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Bromo-substituted indirubins for inhibition of protein kinase-mediated signalling involved in inflammatory mediator release in human monocytes
Bachmann, Vivien; Schädel, Patrick; Westhoff, Jan; Perić, Milica; Schömberg, Fritz; Skaltsounis, Alexios-Leandros; Höppener, Stephanie; Pantsar, Tatu; Fischer, Dagmar; Vilotijević, Ivan; Werz, Oliver. 2024. Bioorganic chemistry. 149: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
In Silico Evaluation of the Thr58-Associated Conserved Water with KRAS Switch-II Pocket Binders
Leini, Renne; Pantsar, Tatu. 2023. Journal of chemical information and modeling. 63: 1490-1505 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Decisive role of water and protein dynamics in residence time of p38α MAP kinase inhibitors
Pantsar, Tatu; Kaiser, Philipp D; Kudolo, Mark; Forster, Michael; Rothbauer, Ulrich; Laufer, Stefan A. 2022. Nature communications. 13: . 569 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Discovery and Development of First-in-Class ACKR3/CXCR7 Superagonists for Platelet Degranulation Modulation
Bayrak, Alp; Mohr, Florian; Kolb, Kyra; Szpakowska, Martyna; Shevchenko, Ekaterina; Dicenta, Valerie; Rohlfing, Anne-Katrin; Kudolo, Mark; Pantsar, Tatu; Günther, Marcel; Kaczor, Agnieszka A.; Poso, Antti; Chevigné, Andy; Pillaiyar, Thanigaimalai; Gawaz, Meinrad; Laufer, Stefan A.. 2022. Journal of medicinal chemistry. 65: 13365–13384 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Discrepancy in interactions and conformational dynamics of pregnane X receptor (PXR) bound to an agonist and a novel competitive
Rashidian, Azam; Mustonen, Enni-Kaisa; Kronenberger, Thales; Schwab, Matthias; Burk, Oliver; Laufer, Stefan A; Pantsar, Tatu. 2022. Computational and Structural Biotechnology Journal. 20: 3004-3018 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Regulatory spine RS3 residue of protein kinases: a lipophilic bystander or a decisive element in the small-molecule kinase inhibitor binding?
Shevchenko, Ekaterina; Pantsar, Tatu. 2022. Biochemical society transactions. 50: 633-648 A2 Katsausartikkeli tieteellisessä aikakauslehdessä