The aim of my research is to find novel drug therapies for neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases, that don’t currently have curative treatment. Our long-term research topic has been PREP enzyme and targeting on it with small-molecular compounds, and we have shown that by targeting PREP we can block several toxic features in models of neurodegenerative diseases. Moreover, based on our PREP research we have found similar multitargeting drug targets, and are currently opening novel research lines.
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17 items-
A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy
Eteläinen, Tony S; Silva, M Catarina; Uhari-Väänänen, Johanna K; De Lorenzo, Francesca; Jäntti, Maria H; Cui, Hengjing; Chavero-Pieres, Marta; Kilpeläinen, Tommi; Mechtler, Christina; Svarcbahs, Reinis; Seppälä, Erin; Savinainen, Juha R; Puris, Elena; Fricker, Gert; Gynther, Mikko; Julku, Ulrika H; Huttunen, Henri J; Haggarty, Stephen J; Myöhänen, Timo T. 2023. Science translational medicine. 15: 1-17 A1 Journal article (refereed), original research -
Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α-Synuclein Mouse Models of Parkinson's Disease
Kilpeläinen, Tommi P; Pätsi, Henri T; Svarcbahs, Reinis; Julku, Ulrika H; Eteläinen, Tony S; Cui, Hengjing; Auno, Samuli; Sipari, Nina; Norrbacka, Susanna; Leino, Teppo O; Jäntti, Maria; Myöhänen, Timo T; Wallén, Erik AA. 2023. Journal of medicinal chemistry. [Publication Date: May 29, 2023]: 1-22 A1 Journal article (refereed), original research -
Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model
Eteläinen, Tony S; Kilpeläinen, Tommi P; Ignatius, Adele; Auno, Samuli; De Lorenzo, Francesca; Uhari-Väänänen, Johanna K; Julku, Ulrika H; Myöhänen, Timo T. 2022. Neuropharmacology. 218: A1 Journal article (refereed), original research -
2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors
Pätsi, Henri T.; Kilpeläinen, Tommi P.; Auno, Samuli; Dillemuth, Pyry M. J.; Arja, Khaled; Lahtela-Kakkonen, Maija K.; Myöhänen, Timo T.; Wallén, Erik A. A.. 2021. Acs medicinal chemistry letters. 12: 1578-1584 A1 Journal article (refereed), original research -
Deletion or inhibition of prolyl oligopeptidase blocks lithium-induced phosphorylation of GSK3b and Akt by activation of protein phosphatase 2A
Myöhänen, Timo T; Mertens, Freke; Norrbacka, Susanna; Cui, Hengjing. 2021. Basic and clinical pharmacology and toxicology. 129: 287-296 A1 Journal article (refereed), original research -
Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration
Hellinen, Laura; Koskela, Ali; Vattulainen, Elina; Liukkonen, Mikko; Wegler, Christine; Treyer, Andrea; Handin, Niklas; Svensson, Richard; Myöhänen, Timo; Poso, Antti; Kaarniranta, Kai; Artursson, Per; Urtti, Arto. 2021. Biomedicine and pharmacotherapy. 2022; 146: 112501 A1 Journal article (refereed), original research -
Prolyl oligopeptidase acts as a link between chaperone-mediated autophagy and macroautophagy
Cui, H.; Norrbacka, S.; Myöhänen, T.T.. 2021. Biochemical pharmacology. 2022; 197: 114899 A1 Journal article (refereed), original research -
Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy
Cui, Hengjing; Kilpeläinen, Tommi; Zouzoula, Lydia; Auno, Samuli; Trontti, Kalevi; Kurvonen, Sampo; Norrbacka, Susanna; Hovatta, Iiris; Jensen, Poul Henning; Myöhänen, Timo T.. 2021. Journal of cellular and molecular medicine. 25: 9634-9646 A1 Journal article (refereed), original research -
Prolyl oligopeptidase inhibition reduces oxidative stress via reducing NADPH oxidase activity by activating protein phosphatase 2A
Eteläinen, T; Kulmala, V; Svarcbahs, R; Jäntti, M; Myohänen, T T. 2021. Free radical biology and medicine. 169: 14-23 A1 Journal article (refereed), original research -
Thymosin β 4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis
Zuo Yiqin, Chun Bongkwon, Potthoff Sebastian A, Kazi Naj, Brolin Tyler J, Orhan Diclehan, Yang Hai-Chun, Ma Li-Jun, Kon Valentina, Myöhänen Timo, Rhaleb Nour-Eddine, Carretero Oscar A, Fogo Agnes B. 2013. Kidney international. 84: 1166-1175 A1 Journal article (refereed), original research