UEF Neurodegeneration - Myohanen Lab

02.08.2021 -

Research group

Our research group is focused on studying the mechanisms and drug targets in neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases, aiming to develop a disease-modifying therapy.

The current treatment of neurodegenerative diseases is mainly symptomatic and is based on replacing the depleted neurotransmitter levels. However, the neuronal death progresses and leads to more severe symptoms where current medications are powerless. Therefore, a disease-modifying therapy to stop or delay the disease progression is urgently needed.

There are several common toxic mechanisms among neurodegenerative diseases. Our aim is to find and identify drug targets that can be used to multitarget on several toxic mechanisms via one target. One such target is PREP enzyme that we have studied over a decade, and by using PREP inhibitors, we have gained excellent results in the models of Parkinson’s and Huntington’s diseases, and in multiple system atrophy.

Funder(s)

Other funders

Academy of Finland

Sigrid Juselius Foundation

Business Finland

Jane and Aatos Erkko Foundation

Keywords

Alzheimer's disease drug development neurodegenerative diseases Parkinson's disease

Time period

02.08.2021 -

Group members - UEF

UEF Neurodegeneration - Myohanen Lab

Funder(s)

Other funders

Keywords

Time period

Group members - UEF

Leader(s)

Professors

Post-doctoral Researchers

Technicians

Other group members

COLLABORATION - UEF

Cooperation partners

Publications by the research group members