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Veli-Pekka Ranta

Veli-Pekka Ranta

University Lecturer

School of Pharmacy, Faculty of Health Sciences

veli-pekka.ranta@uef.fi | +358 40 355 2494

Information Publications

Research groups

Ocular Drug Delivery group (ODD) 01.01.2010 -

Publications

77/77 items

Breast milk oxycodone concentrations in mothers given oxycodone for post‐Caesarean delivery pain management
Pesonen, Aino; Hakomäki, Henriikka; Kokki, Hannu; Ranta, Veli‐Pekka; Rinne, Valtteri; Kokki, Merja. 2024. British journal of clinical pharmacology. [Epub ahead of print 2 Feb 2024]: 1-10
Comment on: Identifying a therapeutic target for vancomycin against staphylococci in young infants
Laitila, Tuomas; Sankilampi, Ulla; Renko, Marjo; Kokki, Merja; Ranta, Veli-Pekka. 2024. Journal of antimicrobial chemotherapy. 79: 692-695
Comprehensive ocular and systemic pharmacokinetics of dexamethasone after subconjunctival and intravenous injections in rabbits
Valtari, Annika; Posio, Susanna; Toropainen, Elisa; Balla, Anusha; Puranen, Jooseppi; Sadeghi, Amir; Ruponen, Marika; Ranta, Veli-Pekka; Vellonen, Kati-Sisko; Urtti, Arto; del Amo, Eva M. 2024. European journal of pharmaceutics and biopharmaceutics. 198:
Quantitative intravitreal pharmacokinetics in mouse as a step towards inter-species translation
Puranen, Jooseppi; Ranta, Veli-Pekka; Ruponen, Marika; Urtti, Arto; Sadeghi, Amir. 2023. Experimental eye research. 235:
Topical pharmacokinetics of brinzolamide suspensions in rabbits and variability analysis for sample size and design considerations
Naageshwaran, Vatsala; Bigonne, Hélène; Gum, Glenwood; Malla, Spundana; del Sol, Charity; Bon, Charles; Xu, Xiaoming; Vo, Anh; Smith, William; O'Reilly Beringhs, Andre; Kozak, Darby; Tan, Ming Liang; Babiskin, Andrew; Urtti, Arto; del Amo, Eva M.; Ranta, Veli Pekka. 2023. International journal of pharmaceutics. 642: . 123183
Värikäs vuosikymmen: Itä-Suomen yliopiston farmasian laitos 50 vuotta
Ranta, Veli-Pekka; Kaltiala, Ulla; Kauppinen, Hanna; Aarnio, Emma; Raunio, Hannu; Räsänen, Paula; Tiihonen, Päivi; Veki, Jaana; Siitonen, Piia. 2023. Publications of the University of Eastern Finland. General series. . Itä-Suomen yliopisto
Central Nervous System Distribution of Buprenorphine in Pregnant Sheep, Fetuses and Newborn Lambs After Continuous Transdermal and Single Subcutaneous Extended-Release Dosing
Hakomäki, Henriikka; Eskola, Sophia; Kokki, Hannu; Lehtonen, Marko; Räsänen, Juha; Laaksonen, Sakari; Voipio, Hanna-Marja; Ranta, Veli-Pekka; Kokki, Merja. 2022. European journal of pharmaceutical sciences. 178:
Comments on “Ocular Pharmacokinetics of Brimonidine Drug Delivery System in Monkeys and Translational Modeling for Selection of Dose and Frequency in Clinical Trials”
del Amo, Eva M; Urtti, Arto; Ranta, Veli-Pekka. 2022. Journal of pharmacology and experimental therapeutics. 383: 246-247
Imaging, quantitation and kinetic modelling of intravitreal nanomaterials
Sadeghi, Amir; Ruponen, Marika; Puranen, Jooseppi; Cao, Shoupeng; Ridolfo, Roxane; Tavakoli, Shirin; Toropainen, Elisa; Lajunen, Tatu; Ranta, Veli-Pekka; van Hest, Jan; Urtti, Arto. 2022. International journal of pharmaceutics. 621:
Quantitative pharmacokinetic analyses of anterior and posterior elimination routes of intravitreal anti-VEGF macromolecules using published human and rabbit data
Lamminsalo, Marko; Urtti, Arto; Ranta, Veli-Pekka. 2022. Experimental eye research. 222:
Topical pharmacokinetics of dexamethasone suspensions in the rabbit eye: Bioavailability comparison
Naageshwaran, Vatsala; Ranta, Veli-Pekka; Toropainen, Elisa; Tuomainen, Marjo; Gum, Glenwood; Xie, Enli; Bhoopathy, Siddhartha; Urtti, Arto; del Amo, Eva M. 2022. International journal of pharmaceutics. 615:
Vankomysiinin annossuositukset 265 aikuispotilaan takautuvasta tutkimuksesta
Hämäläinen, Sari; Kokki, Merja; Ahonen, Jouni; Ojala, Raimo; Romppanen, Jarkko; Lamminsalo, Marko; Ranta, Veli-Pekka . 2022. Duodecim. 138: 831-842
Intranasal Fentanyl for Intervention-Associated Breakthrough Pain After Cardiac Surgery
Valtola, Antti; Laakso, Maisa; Hakomäki, Henriikka; Anderson, Brian J; Kokki, Hannu; Ranta, Veli-Pekka; Rinne, Valtteri; Kokki, Merja. 2021. Clinical pharmacokinetics. 60: 907-919
Maternal and fetal buprenorphine pharmacokinetics in pregnant sheep during transdermal patch dosing: Buprenorphine pharmacokinetics in pregnant sheep
Hakomäki, Henriikka; Kokki, Hannu; Lehtonen, Marko; Räsänen, Juha; Voipio, Hanna-Marja; Ranta, Veli-Pekka; Kokki, Merja. 2021. European journal of pharmaceutical sciences. 165: 105936
Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: tissue exposures in the rabbit eye
Fayyaz, Anam; Vellonen, Kati-Sisko; Ranta, Veli-Pekka; Toropainen, Elisa; Reinisalo, Mika; Valtari, Annika; Puranen, Jooseppi; D'Amico Ricci, Giuseppe; Heikkinen, Emma M.; Gardner, Iain; Ruponen, Marika; Urtti, Arto; Jamei, Masoud; del Amo, Eva M. 2021. European journal of pharmaceutics and biopharmaceutics. 166: 155-162
Pharmacokinetics of Pullulan–Dexamethasone Conjugates in Retinal Drug Delivery
Kicková, Eva; Sadeghi, Amir; Puranen, Jooseppi; Tavakoli, Shirin; Sen, Merve; Ranta, Veli-Pekka; Arango-Gonzalez, Blanca; Bolz, Sylvia; Ueffing, Marius; Salmaso, Stefano; Caliceti, Paolo; Toropainen, Elisa; Ruponen, Marika; Urtti, Arto. 2021. Pharmaceutics. 2022; 14:
Pharmacokinetics of buprenorphine in pregnant sheep after intravenous injection
Hakomäki, Henriikka; Kokki; Hannu; Lehtonen, Marko; Ranta, Veli-Pekka; Räsänen, Juha; Voipio, Hanna-Marja; Kokki, Merja. 2021. Pharmacology research & perspectives. 9: e00726
Pharmacokinetics of intravitreal macromolecules: scaling between rats and rabbits
Sadeghi, Amir; Puranen, Jooseppi; Ruponen, Marika; Valtari, Annika; Subrizi, Astrid; Ranta, Veli-Pekka; Toropainen, Elisa; Urtti, Arto. 2021. European journal of pharmaceutical sciences. 159: 105720
Bioavailability of oxycodone by mouth in coronary artery bypass surgery patients - a randomized trial
Valtola, Antti; Morse, James D; Florkiewicz, Pawel; Hautajärvi, Heidi; Lahtinen, Pasi; Musialowicz, Tadeusz; Anderson, Brian J; Ranta, Veli-Pekka; Kokki, Hannu. 2020. Journal of drug assessment. 9: 117-128
Comprehensive Ocular and Systemic Pharmacokinetics of Brinzolamide in Rabbits After Intracameral, Topical, and Intravenous Administration
Naageshwaran, Vatsala; Ranta, Veli-Pekka; Gum, Glenwood; Bhoopathy, Siddhartha; Urtti, Arto; del Amo, Eva M. 2020. Journal of pharmaceutical sciences. 2021; 110: 529-535
Extended Pharmacokinetic Model of the Intravitreal Injections of Macromolecules in Rabbits. Part 2: Parameter Estimation Based on Concentration Dynamics in the Vitreous, Retina, and Aqueous Humor
Lamminsalo, Marko; Karvinen, Timo; Subrizi, Astrid; Urtti, Arto; Ranta, Veli-Pekka. 2020. Pharmaceutical research. 37: 226
Physiologically based pharmacokinetic modelling of oxycodone drug-drug interactions
Rytkönen, J; Ranta, VP; Kokki, M; Kokki, H; Hautajärvi, H; Rinne, V; Heikkinen, AT. 2020. Biopharmaceutics and drug disposition. 41: 72-88
Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits
Fayyaz, Anam; Ranta, Veli-Pekka; Toropainen, Elisa; Vellonen, Kati-Sisko; Valtari, Annika; Puranen, Jooseppi; Ruponen, Marika; Gardner, Iain; Urtti, Arto; Jamei, Masoud; del Amo, Eva M.. 2020. European journal of pharmaceutical sciences. 155: 105553
Vankomysiinin annoksen säätäminen munuaisten toimintakyvyn ja pitoisuusmääritysten perusteella
Ranta, Veli-Pekka; Ilmavirta, Heikki; Hämäläinen, Sari; Kokki, Merja. 2020. Duodecim. 136: 1301-1310
Analgesic efficacy and pharmacokinetics of epidural oxycodone in pain management after gynaecologic laparoscopy - a randomised, double blind, active control, double-dummy clinical comparison with intravenous administration
Piirainen, P; Kokki, H; Anderson, BJ; Hannam, JA; Hautajärvi, H; Ranta, VP; Kokki, M. 2019. British journal of clinical pharmacology. 85: 1798-1807
Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics
Heikkinen, EM; Auriola, S; Ranta, VP; Demarais, N; Grey, A; Del Amo, E; Toropainen, E; Vellonen, KS; Urtti, A; Ruponen, M. 2019. Molecular pharmaceutics. 16: 3968-3976
Laparoscopic Roux-en-Y gastric bypass surgery influenced pharmacokinetics of several drugs given as a cocktail with the highest impact observed for CYP1A2, CYP2C8 and CYP2E1 substrates
Puris, E; Pasanen, M; Ranta, VP; Gynther, M; Petsalo, A; Käkelä, P; Männistö, V; Pihlajamäki, J. 2019. Basic and clinical pharmacology and toxicology. 125: 123-132
Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits
Fayyaz, A; Ranta, VP; Toropainen, E; Vellonen, KS; Ricci, GD; Reinisalo, M; Heikkinen, EM; Gardner, I; Urtti, A; Jamei, M; del Amo, EM. 2019. Molecular pharmaceutics. 12: e007045
Population pharmacokinetics of oxycodone in plasma and cerebrospinal fluid after epidural and intravenous administration
Lamminsalo, M; Piirainen, P; Kokki, H; Knibbe, CAJ; Ranta, VP; Välitalo, P; Kokki, M. 2019. Expert opinion on drug delivery. 16: 649-656
Bioekvivalenssi ja biosimilaarit
Ranta, Veli-Pekka; Honkakoski, Paavo. Teoksessa: Ruponen, Marika; Urtti, Arto; Pajula, Katja; Honkakoski, Paavo(toim.) , 2018. Biofarmasian perusteet. s. 165-172. Farmasian opiskelijayhdidtys Fortis ry
Biofarmaseuttiset tutkimukset teollisuuden lääkekehityksessä
Honkakoski; Paavo; Korjamo; Timo; Ranta, Veli-Pekka. Teoksessa: Ruponen, Marika; Urtti, Arto; Pajula, Katja; Honkakoski, Paavo(toim.) , 2018. Biofarmasian perusteet. s. 173-200. Farmasian opiskelijayhdidtys Fortis ry
Corneal and conjunctival drug permeability : systematic comparison and pharmacokinetic impact in the eye
Ramsay, Eva; del Amo, Eva M; Toropainen, Elisa; Tengvall-Unadike, Unni; Ranta, Veli-Pekka; Urtti, Arto; Ruponen, Marika. 2018. European journal of pharmaceutical sciences. 119: 83-89
Esterase activity in porcine and albino rabbit ocular tissues
Heikkinen, Emma M; del Amo, Eva M; Ranta, Veli-Pekka; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika. 2018. European journal of pharmaceutical sciences. 123: 106-110
Extended Pharmacokinetic Model of the Rabbit Eye for Intravitreal and Intracameral Injections of Macromolecules: Quantitative Analysis of Anterior and Posterior Elimination Pathways
Lamminsalo, Marko; Taskinen, Ella; Karvinen, Timo; Subrizi, Astrid; Murtomäki, Lasse; Urtti, Arto: Ranta, Veli-Pekka. 2018. Pharmaceutical research. 35: 153
How do different extracorporeal circulation systems affect metoprolol bioavailability in coronary artery bypass surgery patients
Kokki, Hannu; Maaroos, Martin; Ellam, Sten; Halonen, Jari; Ojanperä, Ilkka; Ranta, Merja; Ranta, Veli-Pekka; Tolonen, Aleksandra; Lindberg, Oscar; Viitala, Matias; Hartikainen, Juha. 2018. European journal of clinical pharmacology. 74: 785-792
Oxycodone pharmacokinetics and fetal exposure after intravenous or epidural administration to the ewe
Kinnunen, Mari; Kokki, Hannu; Hautajärvi, Heidi; Huhta, Heikki; Ranta, Veli-Pekka; Räsänen, Juha; Voipio, Hanna-Marja; Kokki, Merja. 2018. Acta obstetricia et gynecologica scandinavica. 97: 1200-1205
Suun kautta otettujen lääkeaineiden imeytyminen
Urtti, Arto; Ruponen, Marika; Pajula, Katja; Yliperttula, Marjo; Honkakoski, Paavo; Ranta, Veli-Pekka; Kidron, Heidi; Vellonen, Kati-Sisko. Teoksessa: Ruponen, Marika; Urtti, Arto; Pajula, Katja; Honkakoski, Paavo(toim.) , 2018. Biofarmasian perusteet. s. 57-96. Farmasian opiskelijayhdidtys Fortis ry
The analgesic efficacy and pharmacokinetics of epidural oxycodone after gynaecological laparotomy: a randomized, double-blind, double-dummy comparison with intravenous administration
Piirainen, Panu; Kokki, Hannu; Hautajärvi, Heidi; Ranta, Veli-Pekka; Kokki, Merja. 2018. British journal of clinical pharmacology. 84: 2088-2096
Absorption of ibuprofen orodispersible tablets in early postoperative phase : a pharmacokinetic study
Piirainen A, Kokki M, Lidsle HM, Lehtonen M, Ranta VP, Kokki H. 2017. Current medical research and opinion. 2018; 34: 683-688
Farmakokinetiikan perusteet
Ranta Veli-Pekka, Honkakoski Paavo, Ruponen Marika, Vellonen Kati-Sisko. 2017. . . Farmasian opiskelijayhdistys Fortis ry
Maturation of Oxycodone Pharmacokinetics in Neonates and Infants: a Population Pharmacokinetic Model of Three Clinical Trials
Välitalo P, Kokki M, Ranta V-P, Olkkola KT, Hooker AC, Kokki H. 2017. Pharmaceutical research. 34: 1125-1133
Foetal Fentanyl Exposure and Ion Trapping after Intravenous and Transdermal Administration to the Ewe
Heikkinen Emma M, Kokki Hannu, Heikkinen Aki, Ranta Veli-Pekka, Räsänen Juha, Voipio Hanna-Marja, Kokki Merja. 2016. Basic and clinical pharmacology and toxicology. 2017; 120: 195-198
General Pharmacokinetic Model for Topically Administered Ocular Drug Dosage Forms
Deng Feng, Ranta Veli-Pekka, Kidron Heidi, Urtti Arto. 2016. Pharmaceutical research. 33: 2680-2690
Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling
Soininen Suvi K, Vellonen Kati-Sisko, Heikkinen Aki T, Auriola Seppo, Ranta Veli-Pekka, Urtti Arto, Ruponen Marika. 2016. Molecular pharmaceutics. 13: 1358-1365
Maturation of oxycodone pharmacokinetics in neonates and infants: Oxycodone and its metabolites in plasma and urine
Kokki Merja, Heikkinen Marja, Välitalo Pyry, Hautajärvi Heidi, Hokkanen Juho, Pitkänen Hanna, Sankilampi Ulla, Ranta Veli-Pekka, Kokki Hannu. 2016. British journal of clinical pharmacology. 2017; 83: 791-800
The cerebrospinal fluid distribution of postoperatively administred dexketoprofen and etoricoxib and their effect on pain and inflammatory markers in patients undergoing hip arthroplasty
Piirainen Annika, Kokki Merja, Hautajärvi Heidi, Lehtonen Marko, Miettinen Hannu, Pulkki Kari, Ranta Veli-Pekka, Kokki Hannu. 2016. Clinical drug investigation. 36: 545-555
Pharmacokinetics of intranasal fentanyl in parturient
Kokki Merja, Heikkinen Aki T, Raatikainen Kaisa, Ranta Veli-Pekka, Hautajärvi H, Kokki Hannu. 2015. British journal of anaesthesia. 115: 635-636
Population pharmacometrics in support of analgesics studies
Välitalo Pyry, Ranta Veli-Pekka, Hooker AC, Kokki Merja, Kokki Hannu. 2014. Acta anaesthesiologica scandinavica. 58: 143-156
Quantitative Analysis of Intracellular Pharmacokinetics of Doxorubicin and its Liposomal Formulations and A Computational Model of the Intracellular PK/PD Relationship
Soininen Suvi K, Välitalo Pyry, Koivisto Heta, Heikkinen Aki, Ranta Veli-Pekka, Vellonen Kati-Sisko, Urtti Arto, Ruponen Marika. 2014. Publications of the University of Eastern Finland. Reports and studies in health sciences
Central nervous system penetration of oxycodone after intravenous and epidural administration
Kokki Merja, Välitalo Pyry, Kuusisto M, Ranta Veli-Pekka, Raatikainen Kaisa, Hautajärvi H, Kokki Hannu. 2013. British journal of anaesthesia. 2014:112: 133-140
Muutosten vuosikymmen : Itä-Suomen yliopiston farmasian laitos 40 vuotta
Ahonen Riitta, Laitinen Kirsti, Lapinjoki Seppo, Mensalo Päivi, Ranta Veli-Pekka, Ylikangas Henna. 2013. Publications of the University of Eastern Finland. General series. . Itä-Suomen yliopisto, farmasian laitos
Metabolism of oxycodone in human hepatocytes from different age groups and prediction of hepatic plasma clearance
Korjamo Timo, Tolonen Ari, Ranta Veli-Pekka, Turpeinen Miia, Kokki Hannu. 2012. Frontiers in pharmacology. 2: 1-7
Pharmacokinetics of Oxycodone in Neonates: Modelling the Development of Clearance
Välitalo Pyry, Olkkola Klaus, Kokki Merja, Kokki Hannu, Ranta Veli-Pekka, Hooker Andrew. 2012. Dosis
Plasma and cerebrospinal fluid pharmacokinetics of naproxen in children
Välitalo Pyry, Kumpulainen Elina, Manner Minna, Kokki Merja, Lehtonen Marko, Hooker Andrew C, Ranta Veli-Pekka, Kokki Hannu. 2012. Journal of clinical pharmacology. 52: 1516-1526
Populaatiofarmakokinetiikan perusteita anestesia- ja tehohoitolääkäreille
Ranta Veli-Pekka, Välitalo Pyry, Kokki Merja, Kokki Hannu. 2012. Finnanest. 45: 128-135
The effect of hydroxypropyl-beta-cyclodextrin and sucrose on the sublingual absorption of midazolam in rabbits
Kaartama Ruut, Turunen Elina, Toljamo Kirsi, Kokki Hannu, Lehtonen Marko, Ranta Veli-Pekka, Savolainen Jouko, Järvinen Kristiina, Jarho Pekka. 2012. European journal of pharmaceutics and biopharmaceutics. 81: 178-183
Barrier analysis of periocular drug delivery to the posterior segment
Ranta V-P, Mannermaa E, Lummepuro K, Subrizi A, Laukkanen A, Antopolsky M, Murtomäki L, Hornof M & Urtti A. 2010. Journal of controlled release. 148: 42-48
Filter-cultured ARPE-19 cells as outer blood-retinal barrier model
Mannermaa E, Reinisalo M, Ranta V-P, Vellonen K-S, Kokki H, Saarikko A, Kaarniranta K & Urtti A. 2010. European journal of pharmaceutical sciences. 40: 289-296
Plasma and cerebrospinal fluid pharmacokinetics of flurbiprofen in children
Kumpulainen E, Välitalo P, Kokki M, Lehtonen M, Hooker A, Ranta V-P & Kokki H. 2010. British journal of clinical pharmacology. 70: 557-566
Efflux protein expression in human retinal pigment epithelium cell lines
Mannermaa E, Vellonen K-S, Ryhänen T, Kokkonen K, Ranta V-P, Kaarniranta K, Urtti A. 2009. Pharmaceutical research. 26: 1785-1791
Intracellular DNA release and elimination correlate poorly with transgene expression after non-viral transfection
Ruponen M, Arkko S, Urtti A, Reinisalo M, Ranta V-P. 2009. Journal of controlled release. 136: 226-231
Passive oral drug absorption can be predicted more reliably by experimental than computational models-Fact or myth
Linnankoski J, Ranta V-P, Yliperttula M, Urtti A. 2008. European journal of pharmaceutical sciences. 34: 129-139
Binding of betaxolol, metoprolol and oligonucleotides to synthetic and bovine ocular melanin, and prediction of drug binding to melanin in human choroid-retinal pigment epithelium
Pitkänen L, Ranta V-P, Moilanen H, Urtti A. 2007. Pharmaceutical research. 24: 2063-2070
Does coronary artery bypass surgery affect metoprolol bioavailability
Valtola A, Kokki H, Gergov M, Ojanperä I, Ranta V-P, Hakala T. 2007. European journal of clinical pharmacology. 63: 471-478
Comparison of oxycodone pharmacokinetics after buccal and sublingual administration in children
Kokki H, Rasanen I, Lasalmi M, Lehtola S, Ranta V-P, Vanamo K, Ojanperä I. 2006. Clinical pharmacokinetics. 45: 745-754
Computational prediction of oral drug absorption based on absorption rate constants in humans
Linnankoski J, Mäkelä JM, Ranta V-P, Urtti A, Yliperttula M. 2006. Journal of medicinal chemistry. 49: 3674-3681
Transscleral drug delivery to the posterior eye: prospects of pharmacokinetic modeling
Ranta V-P, Urtti A. 2006. Advanced drug delivery reviews. 58: 1164-1181
Ocular Delivery of Peptides and Beta-Blocking Agents. Development of Analytical, Cell Culture and Computational Study Methods
Ranta V-P. 2005. Kuopion yliopiston julkaisuja A. Farmaseuttiset tieteet
Permeability of retinal pigment epithelium: Effects of permeant molecular weight and lipophilicity
Pitkänen L, Ranta V-P, Moilanen H, Urtti A. 2005. Investigative ophthalmology and visual science. 46: 641-646
Ocular pharmacokinetic modeling using corneal absorption and desorption rates from in vitro permeation experiments with cultured corneal epithelial cells
Ranta V-P, Laavola M, Toropainen E, Vellonen K-S, Talvitie A, Urtti A. 2003. Pharmaceutical research. 20: 1409-1416
Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model
Toropainen E, Ranta V-P, Vellonen K-S, Palmgrén J, Talvitie A, Laavola M, Suhonen P, Hämäläinen KM, Auriola S, Urtti A. 2003. European journal of pharmaceutical sciences. 20: 99-106
Simultaneous determination of eight beta-blockers by gradient high-performance liquid chromatography with combined ultraviolet and fluorescence detection in corneal permeability studies in vitro
Ranta V-P, Toropainen E, Talvitie A, Auriola S, Urtti A. 2002. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 772: 81-87
Culture model of human corneal epithelium for prediction of ocular drug absorption
Toropainen E, Ranta V-P, Talvitie A, Suhonen P, Urtti A. 2001. Investigative ophthalmology and visual science. 42: 2942-2948
Enzymatic and permeation barrier of [D-Ala2]-met-enkephalinamide in the anterior membranes of the albino rabbit eye
Hämäläinen KM, Ranta V-P, Auriola S, Urtti A. 2000. European journal of pharmaceutical sciences. 9: 265-270
Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites, and enzyme inhibitors using combined ultraviolet and electrochemical detection. II. Application to ocular permeability studies in vitro
Ranta V-P, Hämäläinen KM, Auriola S, Urtti A. 1998. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 709: 1-10
Roles of acid/base nature and molecular weight in drug release from matrices of gelfoam and monoisopropyl ester of poly(vinyl methyl ether-maleic anhydride)
Hämäläinen KM, Määttä E, Piirainen H, Sarkola M, Väisänen A, Ranta V-P, Urtti A. 1998. Journal of controlled release. 56: 273-283
Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites and enzyme inhibitors using combined ultraviolet and electrochemical detection. I. Optimization of separation and detection
Ranta V-P, Urtti A, Auriola S. 1997. Journal of chromatography a. 766: 85-97

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Veli-Pekka Ranta

Research groups

Breast milk oxycodone concentrations in mothers given oxycodone for post‐Caesarean delivery pain management

Comment on: Identifying a therapeutic target for vancomycin against staphylococci in young infants

Comprehensive ocular and systemic pharmacokinetics of dexamethasone after subconjunctival and intravenous injections in rabbits

Quantitative intravitreal pharmacokinetics in mouse as a step towards inter-species translation

Topical pharmacokinetics of brinzolamide suspensions in rabbits and variability analysis for sample size and design considerations

Värikäs vuosikymmen: Itä-Suomen yliopiston farmasian laitos 50 vuotta

Central Nervous System Distribution of Buprenorphine in Pregnant Sheep, Fetuses and Newborn Lambs After Continuous Transdermal and Single Subcutaneous Extended-Release Dosing

Comments on “Ocular Pharmacokinetics of Brimonidine Drug Delivery System in Monkeys and Translational Modeling for Selection of Dose and Frequency in Clinical Trials”

Imaging, quantitation and kinetic modelling of intravitreal nanomaterials

Quantitative pharmacokinetic analyses of anterior and posterior elimination routes of intravitreal anti-VEGF macromolecules using published human and rabbit data

Topical pharmacokinetics of dexamethasone suspensions in the rabbit eye: Bioavailability comparison

Vankomysiinin annossuositukset 265 aikuispotilaan takautuvasta tutkimuksesta

Intranasal Fentanyl for Intervention-Associated Breakthrough Pain After Cardiac Surgery

Maternal and fetal buprenorphine pharmacokinetics in pregnant sheep during transdermal patch dosing: Buprenorphine pharmacokinetics in pregnant sheep

Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: tissue exposures in the rabbit eye

Pharmacokinetics of Pullulan–Dexamethasone Conjugates in Retinal Drug Delivery

Pharmacokinetics of buprenorphine in pregnant sheep after intravenous injection

Pharmacokinetics of intravitreal macromolecules: scaling between rats and rabbits

Bioavailability of oxycodone by mouth in coronary artery bypass surgery patients - a randomized trial

Comprehensive Ocular and Systemic Pharmacokinetics of Brinzolamide in Rabbits After Intracameral, Topical, and Intravenous Administration

Extended Pharmacokinetic Model of the Intravitreal Injections of Macromolecules in Rabbits. Part 2: Parameter Estimation Based on Concentration Dynamics in the Vitreous, Retina, and Aqueous Humor

Physiologically based pharmacokinetic modelling of oxycodone drug-drug interactions

Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits

Vankomysiinin annoksen säätäminen munuaisten toimintakyvyn ja pitoisuusmääritysten perusteella

Analgesic efficacy and pharmacokinetics of epidural oxycodone in pain management after gynaecologic laparoscopy - a randomised, double blind, active control, double-dummy clinical comparison with intravenous administration

Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics

Laparoscopic Roux-en-Y gastric bypass surgery influenced pharmacokinetics of several drugs given as a cocktail with the highest impact observed for CYP1A2, CYP2C8 and CYP2E1 substrates

Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits

Population pharmacokinetics of oxycodone in plasma and cerebrospinal fluid after epidural and intravenous administration

Bioekvivalenssi ja biosimilaarit

Biofarmaseuttiset tutkimukset teollisuuden lääkekehityksessä

Corneal and conjunctival drug permeability : systematic comparison and pharmacokinetic impact in the eye

Esterase activity in porcine and albino rabbit ocular tissues

Extended Pharmacokinetic Model of the Rabbit Eye for Intravitreal and Intracameral Injections of Macromolecules: Quantitative Analysis of Anterior and Posterior Elimination Pathways

How do different extracorporeal circulation systems affect metoprolol bioavailability in coronary artery bypass surgery patients

Oxycodone pharmacokinetics and fetal exposure after intravenous or epidural administration to the ewe

Suun kautta otettujen lääkeaineiden imeytyminen

The analgesic efficacy and pharmacokinetics of epidural oxycodone after gynaecological laparotomy: a randomized, double-blind, double-dummy comparison with intravenous administration

Absorption of ibuprofen orodispersible tablets in early postoperative phase : a pharmacokinetic study

Farmakokinetiikan perusteet

Maturation of Oxycodone Pharmacokinetics in Neonates and Infants: a Population Pharmacokinetic Model of Three Clinical Trials

Foetal Fentanyl Exposure and Ion Trapping after Intravenous and Transdermal Administration to the Ewe

General Pharmacokinetic Model for Topically Administered Ocular Drug Dosage Forms

Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling

Maturation of oxycodone pharmacokinetics in neonates and infants: Oxycodone and its metabolites in plasma and urine

The cerebrospinal fluid distribution of postoperatively administred dexketoprofen and etoricoxib and their effect on pain and inflammatory markers in patients undergoing hip arthroplasty

Pharmacokinetics of intranasal fentanyl in parturient

Population pharmacometrics in support of analgesics studies

Quantitative Analysis of Intracellular Pharmacokinetics of Doxorubicin and its Liposomal Formulations and A Computational Model of the Intracellular PK/PD Relationship

Central nervous system penetration of oxycodone after intravenous and epidural administration

Muutosten vuosikymmen : Itä-Suomen yliopiston farmasian laitos 40 vuotta

Metabolism of oxycodone in human hepatocytes from different age groups and prediction of hepatic plasma clearance

Pharmacokinetics of Oxycodone in Neonates: Modelling the Development of Clearance

Plasma and cerebrospinal fluid pharmacokinetics of naproxen in children

Populaatiofarmakokinetiikan perusteita anestesia- ja tehohoitolääkäreille

The effect of hydroxypropyl-beta-cyclodextrin and sucrose on the sublingual absorption of midazolam in rabbits

Barrier analysis of periocular drug delivery to the posterior segment

Filter-cultured ARPE-19 cells as outer blood-retinal barrier model

Plasma and cerebrospinal fluid pharmacokinetics of flurbiprofen in children

Efflux protein expression in human retinal pigment epithelium cell lines

Intracellular DNA release and elimination correlate poorly with transgene expression after non-viral transfection

Passive oral drug absorption can be predicted more reliably by experimental than computational models-Fact or myth

Binding of betaxolol, metoprolol and oligonucleotides to synthetic and bovine ocular melanin, and prediction of drug binding to melanin in human choroid-retinal pigment epithelium

Does coronary artery bypass surgery affect metoprolol bioavailability

Comparison of oxycodone pharmacokinetics after buccal and sublingual administration in children

Computational prediction of oral drug absorption based on absorption rate constants in humans

Transscleral drug delivery to the posterior eye: prospects of pharmacokinetic modeling

Ocular Delivery of Peptides and Beta-Blocking Agents. Development of Analytical, Cell Culture and Computational Study Methods

Permeability of retinal pigment epithelium: Effects of permeant molecular weight and lipophilicity

Ocular pharmacokinetic modeling using corneal absorption and desorption rates from in vitro permeation experiments with cultured corneal epithelial cells

Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model

Simultaneous determination of eight beta-blockers by gradient high-performance liquid chromatography with combined ultraviolet and fluorescence detection in corneal permeability studies in vitro

Culture model of human corneal epithelium for prediction of ocular drug absorption

Enzymatic and permeation barrier of [D-Ala2]-met-enkephalinamide in the anterior membranes of the albino rabbit eye

Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites, and enzyme inhibitors using combined ultraviolet and electrochemical detection. II. Application to ocular permeability studies in vitro

Roles of acid/base nature and molecular weight in drug release from matrices of gelfoam and monoisopropyl ester of poly(vinyl methyl ether-maleic anhydride)

Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites and enzyme inhibitors using combined ultraviolet and electrochemical detection. I. Optimization of separation and detection