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Ville Männistö

Ville Männistö

Professor

Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences

[email protected]

Information Publications

Publications

70/70 items

ALT levels, alcohol use and metabolic risk factors have prognostic relevance for liver-related outcomes in the general population
Männistö, Ville; Salomaa, Veikko; Jula, Antti; Lundqvist, Annamari; Männistö, Satu; Perola, Markus; Åberg, Fredrik. 2024. JHEP reports. 6: A1 Journal article (refereed), original research
Alcohol-associated liver disease – global epidemiology
Åberg, Fredrik; Jiang, Z Gordon; Cortez-Pinto, Helena; Männistö, Ville. 2024. Hepatology. 80: 1307-1322 A2 Review article, Literature review, Systematic review
An abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns
Deal, Milena; Kar, Asha; Lee, Seung Hyuk T.; Alvarez, Marcus; Rajkumar, Sandhya; Arasu, Uma Thanigai; Kaminska, Dorota; Männistö, Ville; Heinonen, Sini; van der Kolk, Birgitta W.; Säiläkivi, Ulla; Saarinen, Tuure; Juuti, Anne; Pihlajamäki, Jussi; Kaikkonen, Minna U.; Laakso, Markku; Pietiläinen, Kirsi H.; Pajukanta, Päivi. 2024. American journal of human genetics. 111: 2542-2560 A1 Journal article (refereed), original research
Combined use of the CLivD score and FIB-4 for prediction of liver-related outcomes in the population
Åberg, Fredrik; Asteljoki, Juho; Männistö, Ville; Luukkonen, Panu K. 2024. Hepatology. 80: 163-172 A1 Journal article (refereed), original research
IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids
Sasidharan, Kavitha; Caddeo, Andrea; Jamialahmadi, Oveis; Noto, Francesca Rita; Tomasi, Melissa; Malvestiti, Francesco; Ciociola, Ester; Tavaglione, Federica; Mancina, Rosellina M.; Cherubini, Alessandro; Bianco, Cristiana; Mirarchi, Angela; Männistö, Ville; Pihlajamäki, Jussi; Kärjä, Vesa; Grimaudo, Stefania; Luukkonen, Panu K.; Qadri, Sami; Yki-Järvinen, Hannele; Petta, Salvatore; Manfrini, Silvia; Vespasiani-Gentilucci, Umberto; Bruni, Vincenzo; Valenti, Luca; Romeo, Stefano. 2024. Cell reports medicine. 5: A1 Journal article (refereed), original research
Metabolic signatures of metabolic dysfunction-associated steatotic liver disease in severely obese patients
Babu, Ambrin Farizah; Palomurto, Saana; Kärjä, Vesa; Käkelä, Pirjo; Lehtonen, Marko; Hanhineva, Kati; Pihlajamäki, Jussi; Männistö, Ville. 2024. Digestive and liver disease. 56: 2103-2110 A1 Journal article (refereed), original research
Protein Phosphatase 1 Regulatory Subunit 3 Beta rs4240624 Genotype Is Associated With Gallstones and With Significant Changes in Bile Lipidome
Männistö, Ville T; Kaminska, Dorota; Haal, Sylke; Asteljoki, Juho; Luukkonen, Panu K; Käkelä, Pirjo; Tavaglione, Federica; van Weeghel, Michel; Neuvonen, Mikko; Niemi, Mikko; Romeo, Stefano; Nieuwdorp, Max; Pihlajamäki, Jussi; Groen, Albert K. 2024. Gastro hep advances. 3: 594-601 A1 Journal article (refereed), original research
Rasvamaksataudin muuttuva terminologia - vihdoinkin kuvataan, mitä tauti on, eikä sitä, mitä se ei ole
Männistö, Ville; Åberg, Fredrik; Luukkonen, Panu. 2024. Duodecim. 140: 528-530 D1 Article in a trade journal
Serum ferritin level is associated with liver fibrosis and incident liver-related outcomes independent of HFE genotype in the general population
Männistö, Ville T; Hakkarainen, Konsta; Jula, Antti; Lundqvist, Annamari; Vihervaara, Terhi; Erlund, Iris; Åberg, Fredrik. 2024. Scandinavian journal of gastroenterology. 59: 592-599 A1 Journal article (refereed), original research
Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease
Lee, Seung Hyuk T; Garske, Kristina M; Arasu, Uma Thanigai; Kar, Asha; Miao, Zong; Alvarez, Marcus; Koka, Amogha; Darci-Maher, Nicholas; Benhammou, Jihane N; Pan, David Z; Örd, Tiit; Kaminska, Dorota; Männistö, Ville; Heinonen, Sini; Wabitsch, Martin; Laakso, Markku; Agopian, Vatche G; Pisegna, Joseph R; Pietiläinen, Kirsi H; Pihlajamäki, Jussi; Kaikkonen, Minna U; Pajukanta, Päivi. 2024. EBioMedicine. 106: . 105232 A1 Journal article (refereed), original research
Suolistomikrobiston syntetisoima indolipropionihappo metabolisissa sairauksissa
Tuomainen, Marjo; Uusitupa, Matti; Männistö, Ville; Lindström, Jaana; Tuomilehto, Jaakko; Hanhineva, Kati. 2024. Duodecim. 140: 1506-1514 A2 Review article, Literature review, Systematic review
The promise of automated liver disease risk stratification in primary care
Åberg, Fredrik; Männistö, Ville. 2024. The Lancet gastroenterology & hepatology. 2025; 10: 5-7 B1 Non-refereed journal articles
m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1
Xiao, Ling; De Jesus, Dario F; Ju, Cheng-Wei; Wei, Jiang Bo; Hu, Jiang; DiStefano-Forti, Ava; Tsuji, Tadataka; Cero, Cheryl; Männistö, Ville; Manninen, Suvi M; Wei, Siying; Ijaduola, Oluwaseun; Blüher, Matthias; Cypess, Aaron M; Pihlajamäki, Jussi; Tseng, Yu-Hua; He, Chuan; Kulkarni, Rohit N. 2024. Cell metabolism. 36: 2207-2227.e9 A1 Journal article (refereed), original research
CLivD score modifies FIB-4 performance in liver fibrosis detection in the US general population
Åberg, Fredrik; Lääperi, Mitja; Männistö, Ville. 2023. eGastroenterology. 1: . e100035 A1 Journal article (refereed), original research
Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease
Darci-Maher, Nicholas; Alvarez, Marcus; Arasu, Uma Thanigai; Selvarajan, Ilakya; Lee, Seung Hyuk T.; Pan, David Z.; Miao, Zong; Das, Sankha Subhra; Kaminska, Dorota; Örd, Tiit; Benhammou, Jihane N.; Wabitsch, Martin; Pisegna, Joseph R.; Männistö, Ville; Pietiläinen, Kirsi H.; Laakso, Markku; Sinsheimer, Janet S.; Kaikkonen, Minna U.; Pihlajamäki, Jussi; Pajukanta, Päivi. 2023. EBioMedicine. 92: A1 Journal article (refereed), original research
Gut ecological networks reveal associations between bacteria, exercise, and clinical profile in non-alcoholic fatty liver disease patients
Csader, Susanne; Chen, Xiuqiang; Leung, Howell; Männistö, Ville; Pentikäinen, Heikki; Tauriainen, Milla-Maria; Savonen, Kai; El-Nezami, Hani; Schwab, Ursula; Panagiotou, Gianni. 2023. MSystems. 8: A1 Journal article (refereed), original research
Hyperhomocysteinemia predicts liver-related clinical outcomes in the general population
Åberg, Fredrik; Jula, Antti; Lundqvist, Annamari; Männistö, Ville. 2023. Journal of hepatology. 78: e172-e174 B1 Non-refereed journal articles
Liver saturated fat content associates with hepatic DNA methylation in obese individuals
Sehgal, Ratika; Perfilyev, Alexander; Männistö, Ville; Ågren, Jyrki; Nilsson, Emma; Käkelä, Pirjo; Ling, Charlotte; de Mello, Vanessa D.; Pihlajamäki, Jussi. 2023. Clinical epigenetics. 15: . 21 A1 Journal article (refereed), original research
Maksatautikuolleisuus on kasvussa – Joka viides työikäisen miehen kuolema johtuu maksasairaudesta
Åberg, Fredrik; Männistö; Ville; Mäkelä, Pia. 2023. Lääkärilehti. 78: . e37569 A1 Journal article (refereed), original research
Persistent organic pollutants associate with liver disease in a Finnish general population sample
Hakkarainen, Konsta; Rantakokko, Panu; Koponen, Jani; Ruokojärvi, Päivi; Korkalainen, Merja; Salomaa, Veikko; Jula, Antti; Männistö, Satu; Perola, Markus; Lundqvist, Annamari; Männistö, Ville; Aberg, Fredrik. 2023. Liver international. 43: 2177-2185 A1 Journal article (refereed), original research
Plasma Metabolite Signatures in Male Carriers of Genetic Variants Associated with Non-Alcoholic Fatty Liver Disease
Fernandes Silva, Lilian; Vangipurapu, Jagadish; Oravilahti, Anniina; Männistö, Ville; Laakso, Markku. 2023. Metabolites. 13: A1 Journal article (refereed), original research
Twelve Weeks of High-Intensity Interval Training Alters Adipose Tissue Gene Expression but Not Oxylipin Levels in People with Non-Alcoholic Fatty Liver Disease
Csader, Susanne; Ismaiah, Marsena Jasiel; Kuningas, Tiina; Heinäniemi, Merja; Suhonen, Janne; Männistö, Ville; Pentikäinen, Heikki; Savonen, Kai; Tauriainen, Milla-Maria; Galano, Jean-Marie; Lee, Jetty Chung-Yung; Rintamäki, Reeta; Karisola, Piia; El-Nezami, Hani; Schwab, Ursula. 2023. International journal of molecular sciences. 24: A1 Journal article (refereed), original research
Waist-hip ratio is superior to BMI in predicting liver-related outcomes and synergizes with harmful alcohol use
Åberg, Fredrik; Färkkilä, Martti; Salomaa, Veikko; Jula, Antti; Männistö, Satu; Perola, Markus; Lundqvist, Annamari; Männistö, Ville. 2023. Communications medicine. 3: . 119 A1 Journal article (refereed), original research
Alcohol consumption and metabolic syndrome: Clinical and epidemiological impact on liver disease
Åberg, Fredrik; Byrne, Christopher D; Pirola, Carlos J; Männistö, Ville; Sookoian, Silvia. 2022. Journal of hepatology. 2023; 78: 191-206 A2 Review article, Literature review, Systematic review
Association between arterial hypertension and liver outcomes using polygenic risk scores: a population-based study
Åberg, Fredrik; Kantojärvi, Katri; Männistö, Ville; But, Anna; Salomaa, Veikko; Niiranen, Teemu; Färkkilä, Martti; Luukkonen, Panu; Männistö, Satu; Lundqvist, Annamari; Perola, Markus; Jula, Antti. 2022. Scientific reports. 12: . 15581 A1 Journal article (refereed), original research
Attribution of diabetes to the development of severe liver disease in the general population
Vuorinen, Miika; Männistö, Ville T.; Salomaa, Veikko; Britton, Annie; Jula, Antti; Männistö, Satu; Lundqvist, Annamari; Perola, Markus; Åberg, Fredrik. 2022. Liver international. 42: 2186-2194 A1 Journal article (refereed), original research
Comparison of various strategies to define the optimal target population for liver fibrosis screening: A population‐based cohort study
Åberg, Fredrik; Jula, Antti; Färkkilä, Martti; Salomaa, Veikko; Erlund, Iris; Männistö, Satu; Vihervaara, Terhi; Perola, Markus; Lundqvist, Annamari; Männistö, Ville. 2022. United European Gastroenterology journal. 10: 1020-1028 A1 Journal article (refereed), original research
Effects of exercise on NAFLD using non-targeted metabolomics in adipose tissue, plasma, urine, and stool
Babu, Ambrin Farizah; Csader, Susanne; Männistö, Ville; Tauriainen, Milla-Maria; Pentikäinen, Heikki; Savonen, Kai; Klåvus, Anton; Koistinen, Ville; Hanhineva, Kati; Schwab, Ursula. 2022. Scientific reports. 12: A1 Journal article (refereed), original research
Identification of 90 NAFLD GWAS loci and establishment of NAFLD PRS and causal role of NAFLD in coronary artery disease
Miao, Zong; Garske, Kristina M.; Pan, David Z.; Koka, Amogha; Kaminska, Dorota; Männistö, Ville; Sinsheimer, Janet S.; Pihlajamäki, Jussi; Pajukanta, Päivi. 2022. HGG advances. 3: A1 Journal article (refereed), original research
Indolepropionic Acid, a Gut Bacteria-Produced Tryptophan Metabolite and the Risk of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease
Sehgal, Ratika; de Mello, Vanessa D.; Männistö, Ville; Lindström, Jaana; Tuomilehto, Jaakko; Pihlajamäki, Jussi; Uusitupa, Matti. 2022. Nutrients. 14: A2 Review article, Literature review, Systematic review
PSD3 downregulation confers protection against fatty liver disease
Mancina, Rosellina M; Sasidharan, Kavitha; Lindblom, Anna; Wei, Ying; Ciociola, Ester; Jamialahmadi, Oveis; Pingitore, Piero; Andréasson, Anne-Christine; Pellegrini, Giovanni; Baselli, Guido; Männistö, Ville; Pihlajamäki, Jussi; Kärjä, Vesa; Grimaudo, Stefania; Marini, Ilaria; Maggioni, Marco; Becattini, Barbara; Tavaglione, Federica; Dix, Carly; Castaldo, Marie; Klein, Stephanie; Perelis, Mark; Pattou, Francois; Thuillier, Dorothée; Raverdy, Violeta; Dongiovanni, Paola; Fracanzani, Anna Ludovic. 2022. Nature metabolism. 4: 60-75 A1 Journal article (refereed), original research
Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery
van der Kolk, Birgitta; Muniandy, Maheswary; Kaminska, Dorota; Alvarez, Marcus; Ko, Arthur; Miao, Zong; Valsesia, Armand; Langin, Dominique; Vaittinen, Maija; Pääkkönen, Mirva; Jokinen, Riikka; Kaye, Sanna; Heinonen, Sini; Virtanen, Kirsi A; Andersson, Daniel; Männistö, Ville; Saris, Wim; Astrup, Arne; Rydén, Mikael; Blaak, Ellen; Pajukanta, Päivi; Pihlajamäki, Jussi; Pietiläinen, Kirsi H. 2021. Journal of clinical endocrinology and metabolism. 106: 1312-1324 A1 Journal article (refereed), original research
Exome-wide Association Study on Alanine Aminotransferase Identifies Sequence Variants in the GPAM and APOE Associated with Fatty Liver Disease
Jamialahmadi, Oveis; Mancina, Rosellina Margherita; Ciociola, Ester; Tavaglione, Federica; Luukkonen, Panu K; Baselli, Guido; Malvestiti, Francesco; Thuillier, Dorothée; Raverdy, Violeta; Männistö, Ville; Pipitone, Rosaria Maria; Pennisi, Grazia; Prati, Daniele; Spagnuolo, Rocco; Petta, Salvatore; Pihlajamäki, Jussi; Pattou, François; Yki-Järvinen, Hannele; Valenti, Luca; Romeo, Stefano. 2021. Gastroenterology. 160: 1634-1646 A1 Journal article (refereed), original research
Incidence of liver-related morbidity and mortality in a population cohort of non-alcoholic fatty liver disease
Männistö, Ville T.; Salomaa, Veikko; Färkkilä, Martti; Jula, Antti; Männistö, Satu; Erlund, Iris; Sundvall, Jouko; Lundqvist, Annamari; Perola, Markus; Åberg, Fredrik. 2021. Liver international. 41: 2590-2600 A1 Journal article (refereed), original research
Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis
Sehgal, Ratika Ilha, Mariana Vaittinen, Maija Kaminska, Dorota Männistö, Ville Kärjä, Vesa Tuomainen, Marjo Hanhineva, Kati Romeo, Stefano Pajukanta, Päivi Pihlajamäki, Jussi de Mello, Vanessa D.. 2021. Nutrients. 13: 3509 A1 Journal article (refereed), original research
Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease
Selvarajan, Ilakya; Toropainen, Anu; Garske, Kristina M.; López Rodríguez, Maykel; Ko, Arthur; Miao, Zong; Kaminska, Dorota; Õunap, Kadri; Örd, Tiit; Ravindran, Aarthi; Liu, Oscar H.; Moreau, Pierre R.; Jawahar Deen, Ashik; Männistö, Ville; Pan, Calvin; Levonen, Anna-Liisa; Lusis, Aldons J.; Heikkinen, Sami; Romanoski, Casey E.; Pihlajamäki, Jussi; Pajukanta, Päivi; Kaikkonen, Minna U.. 2021. American journal of human genetics. 108: 411-430 A1 Journal article (refereed), original research
Links between gut microbiome composition and fatty liver disease in a large population sample
Ruuskanen, Matti O; Åberg, Fredrik; Männistö, Ville; Havulinna, Aki S; Meric, Guillaume; Liu, Yang; Loomba, Rohit; Vazquez-Baeza, Yoshiki; Tripathi, Anupriya; Valsta, Liisa M; Inouye, Michael; Jousilahti, Pekka; Salomaa, Veikko; Jain, Mohit; Knight, Rob; Lahti, Leo; Niiranen, Teemu J. 2021. Gut microbes. 13: 1-22 A1 Journal article (refereed), original research
Low serum vitamin D level associated with incident advanced liver disease in the general population - a prospective study
Männistö, Ville; Jääskeläinen, Tuija; Farkkila, Martti; Jula, Antti; Männisto, Satu; Lundqvist, Annamari; Zeller, Tanja; Blankenberg, Stefan; Salomaa, Veikko; Perola, Markus; Aberg, Fredrik. 2021. Scandinavian journal of gastroenterology. 56: 299-303 A1 Journal article (refereed), original research
Genetic variants in the MTHFR are not associated with fatty liver disease.
De Vincentis, Antonio; Mancina, Rosellina Margherita; Pihlamajäki, Jussi; Männistö, Ville; Petta, Salvatore; Dongiovanni, Paola; Fracanzani, Anna; Valenti, Luca; Tavaglione, Federica; Romeo, Stefano; Vespasiani-Gentilucci, Umberto. 2020. Liver international. 40: 1934-1940 A1 Journal article (refereed), original research
Interaction between alcohol use and metabolic risk factors for liver disease: a critical review of epidemiological studies
Åberg, Fredrik; Färkkilä, Martti; Männistö, Ville. 2020. Alcoholism-clinical and experimental research. 44: 384-403 A2 Review article, Literature review, Systematic review
PCSK9 rs11591147 R46L loss-of-function variant protects against liver damage in individuals with NAFLD
Grimaudo, Stefania; Bartesaghi, Stefano; Rametta, Raffaela; Marra, Fabio; Margherita Mancina, Rosellina; Pihlajamäki, Jussi; Kakol-Palm, Dorota; Andreasson, Anne-Christine; Dongiovanni, Paola; Ludovica Fracanzani, Anna; Lori, Giulia; Männistö, Ville; Pellegrini, Giovanni; Bohlooly-Y, Mohammad; Pennisi, Grazia; Maria Pipitone, Rosaria; Spagnuolo, Rocco; Craxi, Antonio; Linden, Daniel; Valenti, Luca; et al.. 2020. Liver international. 2021; 41: 321-332 A1 Journal article (refereed), original research
Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice
De Jesus, Dario; Orime, Kazuki; Kaminska, Dorota; Kimura, Tomohiko; Basile, Giorgio; Wang, Chih-Hao; Haertle, Larissa; Riemens, Renzo; Brown, Natalie; Hu, Jiang; Männistö, Ville; Silva, Amélia; Dirice, Ercument; Tseng, Yu-Hua; Haaf, Thomas; Pihlajamäki, Jussi; Kulkarni, Rohit. 2020. Journal of clinical investigation. 130: 2391-2407 A1 Journal article (refereed), original research
Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition
Männistö, Ville; Kaminska, Dorota; Käkelä, Pirjo; Neuvonen, Mikko; Niemi, Mikko; Alvarez, Marcus; Pajukanta, Päivi; Romeo, Stefano; Nieuwdorp, Max; Groen, Albert K; Pihlajamäki, Jussi. 2020. Hepatology communications. 2021; 5: 244-257 B1 Non-refereed journal articles
Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids
de Mello, Vanessa D; Sehgal, Ratika; Männistö, Ville; Klåvus, Anton; Nilsson, Emma; Perfilyev, Alexander; Kaminska, Dorota; Miao, Zong; Pajukanta, Päivi; Ling, Charlotte; Hanhineva, Kati; Pihlajamäki, Jussi. 2020. Liver international. 2021; 41: 754-763 A1 Journal article (refereed), original research
Laparoscopic Roux-en-Y gastric bypass surgery influenced pharmacokinetics of several drugs given as a cocktail with the highest impact observed for CYP1A2, CYP2C8 and CYP2E1 substrates
Puris, E; Pasanen, M; Ranta, VP; Gynther, M; Petsalo, A; Käkelä, P; Männistö, V; Pihlajamäki, J. 2019. Basic and clinical pharmacology and toxicology. 125: 123-132 A1 Journal article (refereed), original research
Liver DNA methylation of FADS2 associates with FADS2 genotypex
Walle, P; Männistö, V; de Mello, VD; Vaittinen, M; Perfilyev, A; Hanhineva, K; Ling, C; Pihlajamäki, J. 2019. Clinical epigenetics. 11: 10 A1 Journal article (refereed), original research
Prevalence and Risk Factors if Significant Fibrosis in Patients With Nonalcoholic Fatty Liver Without Steatohepatitis
Pelusi, S; Cespiati, A; Rametta, R; Pennisi, G; Mannisto, V; Rosso, C; Baselli, G; Dongiovanni, P; Fracanzani, AL; Badiali, S; Maggioni, M; Craxi, A; Fargion, S; Prati, D; Nobili, V; Bugianesi, E; Romeo, S; Pihlajamaki, J; Petta, S; Valenti, L. 2019. Clinical gastroenterology and hepatology. 17: 2310-2319.e6 A1 Journal article (refereed), original research
Serum lipopolysaccharides predict advanced liver disease in the general population
Männistö, Ville; Färkkilä, Martti; Pussinen, Pirkko; Jula, Antti; Männistö, Satu; Lundqvist, Annamari; Valsta, Liisa; Salomaa, Veikko; Perola, Markus; Åberg, Fredrik. 2019. JHEP reports. 1: 345-352 A1 Journal article (refereed), original research
Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression
Männistö, V; Kaminska, D; Kärjä, V; Tiainen, M; de Mello, VD; Hanhineva, K; Soininen, P; Ala-Korpela, M; Pihlajamäki, J. 2019. Liver international. 39: 1895-1905 A1 Journal article (refereed), original research
Kantarelleja iholla
Pitkonen, Kaisa; Männistö, Ville; Rummukainen, Jaana; Siiskonen, Hanna. 2018. Lääkärilehti. 73: 2568-2569 D1 Article in a trade journal
Protein Phosphatase 1 Regulatory Subunit 3B Gene Variation Protects Against Hepatic Fat Accumulation and Fibrosis in Individuals at High Risk of Nonalcoholic Fatty Liver Disease
Dongiovanni, Paola; Meroni, Marica; Mancina, Rosellina M; Baselli, Guido; Rametta, Raffaela; Pelusi, Serena; Männisto, Ville; Fracanzani, Anna L; Badiali, Sara; Miele, Luca; Grimaudo, Stefania; Petta, Salvatore; Bugianesi, Elisabetta; Soardo, Giorgio; Fargion, Silvia; Pihlajamäki, Jussi; Romeo, Stefano; Valenti, Luca. 2018. Hepatology communications. 2: 666-675 A1 Journal article (refereed), original research
Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD
Tauriainen, Milla-Maria; Männistö, Ville; Kaminska, Dorota; Vaittinen, Maija; Kärjä, Vesa; Käkelä, Pirjo; Venesmaa, Sari; Gylling, Helena; Pihlajamäki, Jussi. 2018. Bioscience reports. 38: 1-9 A1 Journal article (refereed), original research
Small Intestinal Length Associates with Serum Triglycerides Before and After LRYGB
Käkelä, Pirjo; Männistö, Ville; Vaittinen, Maija; Venesmaa, Sari; Kärjä, Vesa; Virtanen, Kirsi; Paajanen, Hannu; Pihlajamäki, Jussi. 2018. Obesity surgery. 28: 3969-3975 A1 Journal article (refereed), original research
Alterations in fatty acid metabolism in response to obesity surgery combined with dietary counseling
Walle P, Takkunen M, Männistö V, Vaittinen M, Käkelä P, Ågren J, Schwab U, Lindström J, Tuomilehto J, Uusitupa M, Pihlajamäki J. 2017. Nutrition and diabetes. 7: e285 A1 Journal article (refereed), original research
Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver
Dongiovanni P, Stender S, Pietrelli A, Mancina RM, Cespiati A, Petta S, Pelusi S, Pingitore P, Badiali S, Maggioni M, Mannisto V, Grimaudo S, Pipitone RM, Pihlajamaki J, Craxi A, Taube M, Carlsson LMS, Fargion S, Romeo S, Kozlitina J et al.. 2017. Journal of internal medicine. 2018; 283: 356-370 A1 Journal article (refereed), original research
Comprehensive pharmacogenomic study reveals an important role of UGT1A3 in montelukast pharmacokinetics
Hirvensalo, P; Tornio, A; Neuvonen, M; Tapaninen, T; Paile-Hyvärinen, M; Kärjä, V; Männistö, VT; Pihlajamäki, J; Backman, JT; Niemi, M. 2017. Clinical pharmacology and therapeutics. 2018; 104: 158-168 A1 Journal article (refereed), original research
Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver
García-Calzón Sonia, Perfilyev Alexander, Männistö Ville, de Mello Vanessa D, Nilsson Emma, Pihlajamäki Jussi, Ling Charlotte. 2017. Clinical epigenetics. 9: 102 A1 Journal article (refereed), original research
Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects
Neuvonen M, Tarkiainen EK, Tornio A, Hirvensalo P, Tapaninen T, Paile-Hyvärinen M, Itkonen MK, Holmberg MT, Kärjä V, Männistö VT, Neuvonen PJ, Pihlajamäki J, Backman JT, Niemi M. 2017. Basic and clinical pharmacology and toxicology. 2018; 122: 341-345 A1 Journal article (refereed), original research
Interorgan cross talk between fatty acid metabolism, tissue inflammation, and FADS2 genotype in humans with obesity
Vaittinen M, Männistö V, Käkelä P, Ågren J, Tiainen M, Schwab U, Pihlajamäki J. 2017. Obesity. 25: 545-552 A1 Journal article (refereed), original research
Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity
Walle Paula, Takkunen Markus, Männistö Ville, Vaittinen Maija, Lankinen Maria, Kärjä Vesa, Käkelä Pirjo, Ågren Jyrki, Tiainen Mika, Schwab Ursula, Kuusisto Johanna, Laakso Markku, Pihlajamäki Jussi. 2016. Metabolism: clinical and experimental. 65: 655-666 A1 Journal article (refereed), original research
Serum plant sterols associate with Gallstone disease independent of weight loss and non-alcoholic fatty liver disease
Käkelä P, Männistö V, Ilves I, Vaittinen M, Tauriainen MM, Eskelinen M, Gylling H, Paajanen H, Pihlajamäki J. 2016. Obesity surgery. 27: 1284-1291 A1 Journal article (refereed), original research
The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent
Mancina Rosellina Margherita, Dongiovanni Paola, Petta Salvatore, Pingitore Piero, Meroni Marica, Rametta Raffaela, Borén Jan, Montalcini Tizian, Pujia Arturo, Wiklund Olov, Hindy George, Spagnuolo Rocco, Motta Benedetta Maria, Pipitone Rosaria Maria, Craxì Antonio, Fargion Silvia, Nobili Valerio, Käkelä Pirjo, Kärjä Vesa, Männistö Ville et al. 2016. Gastroenterology. 150: 1219-1230 A1 Journal article (refereed), original research
Biomarkers for non-alcoholic steatohepatitis with special emphasis on lipid metabolism
Männistö Ville. 2015. Publications of the University of Eastern Finland. Dissertations in Health Sciences G5 Doctoral dissertation (article)
FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue
Vaittinen Maija, Walle Paula, Kuosmanen Emmi, Männistö Ville, Käkelä Pirjo, Ågren Jyrki, Schwab Ursula, Pihlajamäki Jussi. 2015. Journal of lipid research. 2016; 57: 56-65 A1 Journal article (refereed), original research
Persistent organic pollutants and non-alcoholic fatty liver disease in morbidly obese patients: a cohort study
Rantakokko Panu, Männistö Ville, Airaksinen Riikka, Koponen Jani, Viluksela Matti, Kiviranta Hannu, Pihlajamäki Jussi. 2015. Environmental health. 14: 79 A1 Journal article (refereed), original research
Statin use and non-alcoholic steatohepatitis in at risk individuals
Dongiovanni Paola, Petta Salvatore, Mannisto Ville, Mancina Rosellina Margherita, Pipitone Rosaria, Karja Vesa, Maggioni Marco, Kakela Pirjo, Wiklund Olov, Mozzi Enrico, Grimaudo Stefania, Kaminska Dorota, Rametta Raffaela, Craxi Antonio, Fargion Silvia, Nobili Valerio, Romeo Stefano, Pihlajamaki Jussi, Valenti Luca. 2015. Journal of hepatology. 63: 705-712 A1 Journal article (refereed), original research
Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans
Männistö Ville T, Simonen Marko, Hyysalo Jenni, Soininen Pasi, Kangas Antti J, Kaminska Dorota, Matte Ananda K, Venesmaa Sari, Käkelä Pirjo, Kärjä Vesa, Arola Johanna, Gylling Helena, Cederberg Henna, Kuusisto Johanna, Laakso Markku, Yki-Järvinen Hannele, Ala-Korpela Mika, Pihlajamäki Jussi. 2014. Liver international. 2015; 35: 1853-1861 A1 Journal article (refereed), original research
Lipoprotein Subclass Metabolism in Non-Alcoholic Steatohepatitis
Männistö Ville T, Simonen Marko, Soininen Pasi, Tiainen Mika, Kangas Antti J, Kaminska Dorota, Venesmaa Sari, Käkelä Pirjo, Kärjä Vesa, Gylling Helena, Ala-Korpela Mika, Pihlajamäki Jussi. 2014. Journal of lipid research. 55: 2676-2684 A1 Journal article (refereed), original research
A population-based study on the prevalence of NASH using scores validated against liver histology
Hyysalo J, Männistö VT, Zhou Y, Arolad J, Kärjä V, Leivonen M, Juut A, Jaser N, Lallukka S, Käkelä P, Venesmaa S, Simonen M, Saltevo J, Moilanen L, Korpi-Hyövalti E, Keinänen-Kiukaanniemi S, Oksa H, Orho-Melander M, Valentik L, Fargionk S, Pihlajamäki J,Peltoneng M, Yki-Järvinena H. 2013. Journal of hepatology. Available online 12 December 2013: - A1 Journal article (refereed), original research
Desmosterol in human nonalcoholic steatohepatitis
Simonen M, Männistö V, Leppänen J, Kaminska D, Kärjä V, Venesmaa S, Käkelä P, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J. 2013. Hepatology. 58: 976-982 A1 Journal article (refereed), original research

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Ville Männistö

ALT levels, alcohol use and metabolic risk factors have prognostic relevance for liver-related outcomes in the general population

Alcohol-associated liver disease – global epidemiology

An abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns

Combined use of the CLivD score and FIB-4 for prediction of liver-related outcomes in the population

IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids

Metabolic signatures of metabolic dysfunction-associated steatotic liver disease in severely obese patients

Protein Phosphatase 1 Regulatory Subunit 3 Beta rs4240624 Genotype Is Associated With Gallstones and With Significant Changes in Bile Lipidome

Rasvamaksataudin muuttuva terminologia - vihdoinkin kuvataan, mitä tauti on, eikä sitä, mitä se ei ole

Serum ferritin level is associated with liver fibrosis and incident liver-related outcomes independent of HFE genotype in the general population

Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease

Suolistomikrobiston syntetisoima indolipropionihappo metabolisissa sairauksissa

The promise of automated liver disease risk stratification in primary care

m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1

CLivD score modifies FIB-4 performance in liver fibrosis detection in the US general population

Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease

Gut ecological networks reveal associations between bacteria, exercise, and clinical profile in non-alcoholic fatty liver disease patients

Hyperhomocysteinemia predicts liver-related clinical outcomes in the general population

Liver saturated fat content associates with hepatic DNA methylation in obese individuals

Maksatautikuolleisuus on kasvussa – Joka viides työikäisen miehen kuolema johtuu maksasairaudesta

Persistent organic pollutants associate with liver disease in a Finnish general population sample

Plasma Metabolite Signatures in Male Carriers of Genetic Variants Associated with Non-Alcoholic Fatty Liver Disease

Twelve Weeks of High-Intensity Interval Training Alters Adipose Tissue Gene Expression but Not Oxylipin Levels in People with Non-Alcoholic Fatty Liver Disease

Waist-hip ratio is superior to BMI in predicting liver-related outcomes and synergizes with harmful alcohol use

Alcohol consumption and metabolic syndrome: Clinical and epidemiological impact on liver disease

Association between arterial hypertension and liver outcomes using polygenic risk scores: a population-based study

Attribution of diabetes to the development of severe liver disease in the general population

Comparison of various strategies to define the optimal target population for liver fibrosis screening: A population‐based cohort study

Effects of exercise on NAFLD using non-targeted metabolomics in adipose tissue, plasma, urine, and stool

Identification of 90 NAFLD GWAS loci and establishment of NAFLD PRS and causal role of NAFLD in coronary artery disease

Indolepropionic Acid, a Gut Bacteria-Produced Tryptophan Metabolite and the Risk of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease

PSD3 downregulation confers protection against fatty liver disease

Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery

Exome-wide Association Study on Alanine Aminotransferase Identifies Sequence Variants in the GPAM and APOE Associated with Fatty Liver Disease

Incidence of liver-related morbidity and mortality in a population cohort of non-alcoholic fatty liver disease

Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease

Links between gut microbiome composition and fatty liver disease in a large population sample

Low serum vitamin D level associated with incident advanced liver disease in the general population - a prospective study

Genetic variants in the MTHFR are not associated with fatty liver disease.

Interaction between alcohol use and metabolic risk factors for liver disease: a critical review of epidemiological studies

PCSK9 rs11591147 R46L loss-of-function variant protects against liver damage in individuals with NAFLD

Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice

Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition

Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids

Laparoscopic Roux-en-Y gastric bypass surgery influenced pharmacokinetics of several drugs given as a cocktail with the highest impact observed for CYP1A2, CYP2C8 and CYP2E1 substrates

Liver DNA methylation of FADS2 associates with FADS2 genotypex

Prevalence and Risk Factors if Significant Fibrosis in Patients With Nonalcoholic Fatty Liver Without Steatohepatitis

Serum lipopolysaccharides predict advanced liver disease in the general population

Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression

Kantarelleja iholla

Protein Phosphatase 1 Regulatory Subunit 3B Gene Variation Protects Against Hepatic Fat Accumulation and Fibrosis in Individuals at High Risk of Nonalcoholic Fatty Liver Disease

Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD

Small Intestinal Length Associates with Serum Triglycerides Before and After LRYGB

Alterations in fatty acid metabolism in response to obesity surgery combined with dietary counseling

Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver

Comprehensive pharmacogenomic study reveals an important role of UGT1A3 in montelukast pharmacokinetics

Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver

Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects

Interorgan cross talk between fatty acid metabolism, tissue inflammation, and FADS2 genotype in humans with obesity

Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity

Serum plant sterols associate with Gallstone disease independent of weight loss and non-alcoholic fatty liver disease

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

Biomarkers for non-alcoholic steatohepatitis with special emphasis on lipid metabolism

FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue

Persistent organic pollutants and non-alcoholic fatty liver disease in morbidly obese patients: a cohort study

Statin use and non-alcoholic steatohepatitis in at risk individuals

Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans

Lipoprotein Subclass Metabolism in Non-Alcoholic Steatohepatitis

A population-based study on the prevalence of NASH using scores validated against liver histology

Desmosterol in human nonalcoholic steatohepatitis