Pirkka Kirjavainen

Maternal caffeine intake during pregnancy and the risk of delivering a small for gestational age baby: Kuopio Birth Cohort

Kukkonen, Anni; Hantunen, Sari; Voutilainen, Ari; Ruusunen, Anu; Backman, Katri; Kirjavainen, Pirkka V.; Ylilauri, Maija; Voutilainen, Raimo; Pasanen, Markku; Keski-Nisula, Leea. 2024. Archives of gynecology and obstetrics. 310: 359-368 A1 Journal article (refereed), original research

Maternal caffeine, coffee and cola drink intake and the risk of gestational diabetes – Kuopio Birth Cohort

Kukkonen, Anni; Hantunen, Sari; Voutilainen, Ari; Ruusunen, Anu; Uusitalo, Lauri; Backman, Katri; Voutilainen, Raimo; Pasanen, Markku; Kirjavainen, Pirkka V; Keski-Nisula, Leea. 2024. Primary care diabetes. 18: 362-367 A1 Journal article (refereed), original research

Microbial exposure at birth and the development of behavioral temperament during the first three years of childhood

Chortatos, Arthur; Pesonen, Maiju; Thomas, Owen; Toffol, Elena; Airaksinen, Ville; Musakka, Emma; Täubel, Martin; Kirjavainen, Pirkka; Backman, Katri; Pekkanen, Juha; Keski-Nisula, Leea; Lehto, Soili M. 2024. Development and psychopathology. [Published online: 16 October 2024]: 1-12 A1 Journal article (refereed), original research

Continuous rather than solely early farm exposure protect from hay fever development

Pechlivanis, Sonali; Depner, Martin; Kirjavainen, Pirkka V; Roduit, Caroline; Täubel, Martin; Frei, Remo; Skevaki, Chrysanthi; Hose, Alexander; Barnig, Cindy; Schmausser-Hechfellner, Elisabeth; Ege, Markus J; Schaub, Bianca; Divaret-Chauveau, Amandine; Lauener, Roger; Karvonen, Anne M; Pekkanen, Juha; Riedler, Josef; Illi, Sabina; von Mutius, Erika. 2023. Journal of allergy and clinical immunology : in practice. 11: 591-601 A1 Journal article (refereed), original research

Early-life environment and the risk of eczema at 2 years-Meta-analyses of six Finnish birth cohorts

Lukkarinen, Minna; Kirjavainen, Pirkka V; Backman, Katri; Gonzales-Inca, Carlos; Hickman, Brandon; Kallio, Sampo; Karlsson, Hasse; Karlsson, Linnea; Keski-Nisula, Leea; Korhonen, Laura S; Korpela, Katri; Kuitunen, Mikael; Kukkonen, Anna Kaarina; Kayhko, Niina; Lagstrom, Hanna; Lukkarinen, Heikki; Peltola, Ville; Pentti, Jaana; Salonen, Anne; Savilahti, Erkki; Tuoresmaki, Pauli; Taubel, Martin; Vahtera, Jussi; de Vos, Willem M; Pekkanen, Juha; Karvonen, Anne M. 2023. Pediatric allergy and immunology. 34: A1 Journal article (refereed), original research

Fungi in Early-Life House Dust Samples and the Development of Asthma: A Birth Cohort Study

Täubel, Martin; Jalanka, Jonna; Kirjavainen, Pirkka V; Tuoresmäki, Pauli; Hyvärinen, Anne; Skevaki, Chrysanthi; Piippo-Savolainen, Eija; Pekkanen, Juha; Karvonen, Anne M. 2023. Annals of the American Thoracic Society. 20: 1456-1464 A1 Journal article (refereed), original research

Kotipölystä sekvensoitujen sienten yhteys astmaan - tuloksia suomalaisesta syntymäkohorttitutkimuksesta

Karvonen, Anne M; Täubel, Martin; Jalanka, Jonna; Kirjavainen, Pirkka V; Tuoresmäki, Pauli; Piippo-Savolainen, Eija; Hyvärinen, Anne; Pekkanen, Juha. Teoksessa: Ahola, Mervi; Merikari, Anna(toim.) , 2023. Sisäilmastoseminaari 2023. s. 343-348. Siy sisäilmatieto oy D3 Professional conference proceedings

Associations between residential greenness, indoor microbiota and risk of developing allergic rhinitis

Tischer, Christina; Zacheus, Teemu; Täubel, Martin; Gonzales-Inca, Carlos; Jalanka, Jonna; Tuoresmäki, Pauli; Jayaprakash, Balamuralikrishna; Vahtera, Jussi; Hyvärinen, Anne; Pekkanen, Juha; Karvonen, Anne M; Kirjavainen, Pirkka V. 2022. abstract

Bifidobacterium Species Colonization in Infancy: A Global Cross-Sectional Comparison by Population History of Breastfeeding

Taft, Diana H.; Lewis, Zachery T.; Nguyen, Nhu; Ho, Steve; Masarweh, Chad; Dunne-Castagna, Vanessa; Tancredi, Daniel J.; Huda, M. Nazmul; Stephensen, Charles B.; Hinde, Katie; von Mutius, Erika; Kirjavainen, Pirkka V.; Dalphin, Jean-Charles; Lauener, Roger; Riedler, Josef; Smilowitz, Jennifer T.; German, J. Bruce; Morrow, Ardythe L.; Mills, David A.. 2022. Nutrients. 14: A1 Journal article (refereed), original research

Determinants of bacterial and fungal microbiota in Finnish home dust: Impact of environmental biodiversity, pets, and occupants

Hickman, Brandon; Kirjavainen, Pirkka V.; Täubel, Martin; de Vos, Willem M.; Salonen, Anne; Korpela, Katri. 2022. Frontiers in microbiology. 13: A1 Journal article (refereed), original research

Early‐life residential exposure to moisture damage is associated with persistent wheezing in a Finnish birth cohort

Tischer, Christina; Täubel, Martin; Kirjavainen, Pirkka V; Depner, Martin; Hyvärinen, Anne; Piippo‐Savolainen, Eija; Pekkanen, Juha; Karvonen, Anne M. 2022. Pediatric allergy and immunology. 33: A1 Journal article (refereed), original research

Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers

Illi, S; Depner, M; Pfefferle, PI; Renz, H; Roduit, C; Taft, DH; Kalanetra, KM; Mills, DA; Farquharson, FM; Louis, P; Schmausser-Hechfellner, E; Divaret-Chauveau, A; Lauener, R; Karvonen, AM; Pekkanen, J; Kirjavainen, PV; Roponen, M; Riedler, J; Kabesch, M; Schaub, B; von Mutius, E; PASTURE Study Group. 2022. American journal of respiratory and critical care medicine. 205: 641-650 A1 Journal article (refereed), original research

Interplay between natural environment, human microbiota and immune system: A scoping review of interventions and future perspectives towards allergy prevention

Tischer, Christina; Kirjavainen, Pirkka; Matterne, Uwe; Tempes, Jana; Willeke, Kristina; Keil, Thomas; Apfelbacher, Christian; Täubel, Martin. 2022. Science of the total environment. 821: A2 Review article, Literature review, Systematic review

Role of house dust microbiota in health benefits of dog keeping

Mäki, Jenni M; Kirjavainen, Pirkka V; Täubel, Martin; Piippo-Savolainen, Eija; Backman, Katri; Pekkanen, Juha; Karvonen, Anne M. 2022. abstract

The Effects of Single Strains and Mixtures of Probiotic Bacteria on Immune Profile in Liver, Spleen, and Peripheral Blood

Fong, Fiona Long Yan; El-Nezami, Hani; Mykkänen, Otto; Kirjavainen, Pirkka V.. 2022. Frontiers in nutrition. 9: . 73298 A1 Journal article (refereed), original research

The Microbiome as a Gateway to Prevention of Allergic Disease Development

Kloepfer, Kirsten M; McCauley, Kathryn E; Kirjavainen, Pirkka V. 2022. Journal of allergy and clinical immunology : in practice. 10: 2195-2204 A2 Review article, Literature review, Systematic review

Associations between dog keeping and indoor dust microbiota

Mäki, Jenni M; Kirjavainen, Pirkka V; Taubel, Martin; Piippo-Savolainen, Eija; Backman, Katri; Hyvärinen, Anne; Tuoresmäki, Pauli; Jayaprakash, Balamuralikrishna; Heinrich, Joachim; Herberth, Gunda; Standl, Marie; Pekkanen, Juha; Karvonen, Anne M. 2021. Scientific reports. 11: 5341 A1 Journal article (refereed), original research

Early age exposure to moisture and mould is related to FeNO at the age of 6 years

Tischer, Christina; Karvonen, Anne M; Kirjavainen, Pirkka V; Flexeder, Claudia; Roponen, Marjut; Hyvärinen, Anne; Renz, Harald; Frey, Urs Peter; Fuchs, Oliver; Pekkanen, Juha. 2021. Pediatric allergy and immunology. 32: 1226-1237 A1 Journal article (refereed), original research

Excessive Unbalanced Meat Consumption in the First Year of Life Increases Asthma Risk in the PASTURE and LUKAS2 Birth Cohorts

Hose, Alexander J; Genuneit, Jon; Pagani, Giulia; Roduit, Caroline; Schmauaer-Hechfellner, Elisabeth; Karvonen, Anne M; Kirjavainen, Pirkka V; Roduit, Caroline; Genuneit, Jon; Schmaußer-Hechfellner, Elisabeth; Depner, Martin; Frei, Remo; Lauener, Roger; Riedler, Josef; Schaub, Bianca; Fuchs, Oliver; von Mutius, Erika; Divaret-Chauveau, Amandine; Pekkanen, Juha; Ege, Markus J. 2021. Frontiers in immunology. 12: 1-14 A1 Journal article (refereed), original research

Microbial diversity in homes and the risk of allergic rhinitis and inhalant atopy in two European birth cohorts

Hyytiäinen, Heidi; Kirjavainen, Pirkka V; Täubel, Martin; Tuoresmäki, Pauli; Casas, Lidia; Heinrich, Joachim; Herberth, Gunda; Standl, Marie; Renz, Harald; Piippo-Savolainen, Eija; Hyvärinen, Anne; Pekkanen, Juha; Karvonen, Anne M. 2021. Environmental research. 196: 110835 A1 Journal article (refereed), original research

Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma

Depner, Martin; Taft, Diana Hazard; Kirjavainen, Pirkka V; Kalanetra, Karen M; Karvonen, Anne M; Peschel, Stefanie; Schmausser-Hechfellner, Elisabeth; Roduit, Caroline; Frei, Remo; Lauener, Roger; Divaret-Chauveau, Amandine; Dalphin, Jean-Charles; Riedler, Josef; Roponen, Marjut; Kabesch, Michael; Renz, Harald; Pekkanen, Juha; Farquharson, Freda M; Louis, Petra; Mills, David A. et al.. 2020. Nature medicine. 26: 1766-1775 A1 Journal article (refereed), original research

Reply

Karvonen, Anne; Kirjavainen, Pirkka; Täubel, Martin; Pekkanen, Juha. 2020. Journal of allergy and clinical immunology. 145: 1307-1308 B1 Non-refereed journal articles

Decreased plasma serotonin and other metabolite changes in healthy adults after consumption of wholegrain rye: an untargeted metabolomics study

Keski-Rahkonen, Pekka; Kolehmainen, Marjukka; Lappi, Jenni; Micard, Valerie; Jokkala, Jenna; Rosa-Sibakov, Natalia; Pihlajamäki, Jussi; Kirjavainen, Pirkka V; Mykkänen, Hannu; Poutanen, Kaisa; Gunter, Marc J; Scalbert, Augustin; Hanhineva, Kati. 2019. American journal of clinical nutrition. 109: 1630-1639 A1 Journal article (refereed), original research

Early life home microbiome and hyperactivity/inattention in school-age children

Casas, L; Karvonen, AM; Kirjavainen, PV; Täubel, M; Hyytiäinen, H; Jayaprakash, B; Lehmann, I; Standl, M; Pekkanen, J; Heinrich, J. 2019. Scientific reports. 9: 17355 A1 Journal article (refereed), original research

Farm-like indoor microbiota in non-farm homes protects children from asthma development

Kirjavainen, PV; Karvonen, AM; Adams, RI; Täubel, M; Roponen, M; Tuoresmäki, P; Loss, G; Jayaprakash, B; Depner, M; Ege, MJ; Renz, H; Pfefferle, PI; Schaub, B; Lauener, R; Hyvärinen, A; Knight, R; Heederik, DJJ; von Mutius, E; Pekkanen, J. 2019. Nature medicine. 25: 1089-1095 A1 Journal article (refereed), original research

Indoor Bacterial Microbiota and the Development of Asthma by 10.5 years of age

Karvonen, AM; Kirjavainen, PV; Täubel, M; Jayaprakash, B; Adams, RI; Sordillo, JE; Gold, DR; Hyvärinen, A; Remes, S; von Mutius, E; Pekkanen, J. 2019. Journal of allergy and clinical immunology. 144: 1402-1410 A1 Journal article (refereed), original research

Maatalomainen kodin mikrobisto voi suojata astmalta kaupungissakin

Kirjavainen, PV; Karvonen, AM; Adams, RI; Täubel, M; Roponen, M; Tuoresmäki, P; Loss, G; Jayaprakash, B; Depner, M; Ege, MJ; Renz, H; Pfefferle, PI; Schaub, B; Lauener, R; Hyvärinen, A; Knight, R; Heederik, DJJ; von Mutius, E; Pekkanen, J. 2019. Duodecim. 135: 1309 D1 Article in a trade journal

Parents know it best: Prediction of asthma and lung function by parental perception of early wheezing episodes

Brick, Tabea; Hose, Alexander; Wawretzka, Katharina; von Mutius, Erika; Roduit, Caroline; Lauener, Roger; Riedler, Josef; Karvonen, Anne M; Pekkanen, Juha; Divaret-Chauveau, Amandine; Dalphin, Jean-Charles; Ege, Markus J; PASTURE study group (incl. Roponen, Marjut; Hirvonen, Maija-Riitta; Kirjavainen, Pirkka Viljami). 2019. Pediatric allergy and immunology. 30: 795-802 A1 Journal article (refereed), original research

Crawling-induced floor dust resuspension affects the microbiota of the infant breathing zone

Hyytiäinen, Heidi K; Jayaprakash, Balamuralikrishna; Kirjavainen, Pirkka V; Saari, Sampo E; Holopainen, Rauno; Keskinen, Jorma; Hämeri, Kaarle; Hyvärinen, Anne; Boor, Brandon E; Täubel, Martin. 2018. Microbiome. 6: 25 A1 Journal article (refereed), original research

Early age exposure to moisture damage and systemic inflammation at the age of 6 years

Karvonen, AM; Tischer, C; Kirjavainen, PV; Roponen, M; Hyvärinen, A; Illi, S; Mustonen, K; Pfefferle, PI; Renz, H; Remes, S; Schaub, B; von Mutius, E; Pekkanen, J. 2018. Indoor air. 28: 450-458 A1 Journal article (refereed), original research

High levels of Butyrate and Propionate in early life are associated with protection against atopy

Roduit, C; Frei, R; Ferstl, R; Loeliger, S; Westermann, P; Rhyner, C; Schiavi, E; Barcik, W; Rodriguez-Perez, N; Wawrzyniak, M; Chassard, C; Lacroix, C; Schmausser-Hechfellner, E; Depner, M; von Mutius, E; Braun-Fahrländer, C; Karvonen, A; Kirjavainen, P; Pekkanen, J; Dalphin, JC; et al. 2018. Allergy. 2019; 74: 799-809 A1 Journal article (refereed), original research

Immunomodulatory effects of Lactobacillus rhamnosus GG on dendritic cells, macrophages and monocytes from healthy donors

Fong Fiona Long Yan, Kirjavainen Pirkka, Wong Victoria Ho Yee, El-Nezami Hani. 2015. Journal of functional foods. 13: 71-79 A1 Journal article (refereed), original research

Microbial secondary metabolites in homes in association with moisture damage and asthma

Kirjavainen PV, Täubel M, Karvonen AM, Sulyok M, Tiittanen P, Krska R, Hyvärinen A, Pekkanen J. 2015. Indoor air. first published online: 3 JUN 2015: - A1 Journal article (refereed), original research

Postprandial glucose metabolism and SCFA after consuming wholegrain rye bread and wheat bread enriched with bioprocessed rye bran in individuals with mild gastrointestinal symptoms

Lappi Jenni, Mykkänen Hannu, Bach Knudsen Knud Erik, Kirjavainen Pirkka, Katina Kati, Pihlajamäki Jussi, Poutanen Kaisa, Kolehmainen Marjukka. 2014. Nutrition journal. 13: - A1 Journal article (refereed), original research

Wild Blueberries (Vaccinium myrtillus) Alleviate Inflammation and Hypertension Associated with Developing Obesity in Mice Fed with a High-Fat Diet

Mykkänen Otto T, Huotari Anne, Herzig Karl-Heinz, Dunlop Thomas W, Mykkänen Hannu, Kirjavainen Pirkka V. 2014. PLoS ONE. 9: e114790 A1 Journal article (refereed), original research

Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome

Kolehmainen M, Mykkänen O, Kirjavainen PV, Leppänen T, Moilanen E, Adriaens M, Laaksonen DE, Hallikainen M, Puupponen-Pimiä R, Pulkkinen L, Mykkänen H, Gylling H, Poutanen K, Törrönen R. 2012. Molecular nutrition and food research. 56: 1501-1510 A1 Journal article (refereed), original research

Ravinto ja suolistomikrobisto

Kirjavainen P, von Wright A, Mykkänen H. Teoksessa: Aro A, Mutanen M, Uusitupa M(toim.) , 2012. Ravitsemustiede. s. 183-195. Duodecim D2 Article in a professional book (incl. an introduction by the editor)

Development and pilot evaluation of a novel probiotic mixture for the management of seasonal allergic rhinitis

Koyama T, Kirjavainen PV, Fisher C, Anukam CF, Summers K, Hekmat S & Reid G. 2010. Canadian journal of microbiology. 56: 730-438 A1 Journal article (refereed), original research

Abnormal immunological profile and vaginal microbiota in women prone to urinary tract infections

Kirjavainen PV, Pautler S, Baroja ML, Anukam K, Crowley K, Carter K, Reid G, Kirjavainen PV. 2009. Clinical and vaccine immunology. 16: 29-36 A1 Journal article (refereed), original research

Effect of bacterial vaginosis, Lactobacillus and premarin estrogen replacement therapy on vaginal gene expression changes

Dahn A, Saunders S, Hammond J-A, Carter D, Kirjavainen P, Anukam K, Reid G, Kirjavainen Pirkka. 2008. Microbes and infection. 10: 620-627 A1 Journal article (refereed), original research

Expression of anti-microbial defence factors in vaginal mucosa following exposure to Lactobacillus rhamnosus GR-1

Kirjavainen PV, Laine RM, Carter DE, Hammond J-O, Reid G. 2008. International journal of probiotics & prebiotics. 3: 99-106 A1 Journal article (refereed), original research

Anti-inflammatory effects of probiotic yogurt in inflammatory bowel disease patients

Baroja ML, Kirjavainen PV, Hekmat S, Reid G. 2007. Clinical and experimental immunology. 149: 470-479 A1 Journal article (refereed), original research

Postnatal effects of obstetrical epidural anesthesia on allergic sensitization

Kirjavainen PV, Kalliomäki M, Salminen SJ, Isolauri E, Kirjavainen PV. 2007. Allergy. 62: 87-88 A1 Journal article (refereed), original research

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Research groups

Maternal caffeine intake during pregnancy and the risk of delivering a small for gestational age baby: Kuopio Birth Cohort

Maternal caffeine, coffee and cola drink intake and the risk of gestational diabetes – Kuopio Birth Cohort

Microbial exposure at birth and the development of behavioral temperament during the first three years of childhood

Continuous rather than solely early farm exposure protect from hay fever development

Early-life environment and the risk of eczema at 2 years-Meta-analyses of six Finnish birth cohorts

Fungi in Early-Life House Dust Samples and the Development of Asthma: A Birth Cohort Study

Kotipölystä sekvensoitujen sienten yhteys astmaan - tuloksia suomalaisesta syntymäkohorttitutkimuksesta

Associations between residential greenness, indoor microbiota and risk of developing allergic rhinitis

Bifidobacterium Species Colonization in Infancy: A Global Cross-Sectional Comparison by Population History of Breastfeeding

Determinants of bacterial and fungal microbiota in Finnish home dust: Impact of environmental biodiversity, pets, and occupants

Early‐life residential exposure to moisture damage is associated with persistent wheezing in a Finnish birth cohort

Environmental microbiota transfer into urban homes

Farm home-like indoor microbiota protects form asthma in urban homes

Fungal diversity and quantity in house dust and wheezing phenotypes

Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers

Interplay between natural environment, human microbiota and immune system: A scoping review of interventions and future perspectives towards allergy prevention

Role of house dust microbiota in health benefits of dog keeping

The Effects of Single Strains and Mixtures of Probiotic Bacteria on Immune Profile in Liver, Spleen, and Peripheral Blood

The Microbiome as a Gateway to Prevention of Allergic Disease Development

Associations between dog keeping and indoor dust microbiota

Early age exposure to moisture and mould is related to FeNO at the age of 6 years

Excessive Unbalanced Meat Consumption in the First Year of Life Increases Asthma Risk in the PASTURE and LUKAS2 Birth Cohorts

Microbial diversity in homes and the risk of allergic rhinitis and inhalant atopy in two European birth cohorts

Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma

Reply

Decreased plasma serotonin and other metabolite changes in healthy adults after consumption of wholegrain rye: an untargeted metabolomics study

Early life home microbiome and hyperactivity/inattention in school-age children

Farm-like indoor microbiota in non-farm homes protects children from asthma development

Indoor Bacterial Microbiota and the Development of Asthma by 10.5 years of age

Maatalomainen kodin mikrobisto voi suojata astmalta kaupungissakin

Parents know it best: Prediction of asthma and lung function by parental perception of early wheezing episodes

Crawling-induced floor dust resuspension affects the microbiota of the infant breathing zone

Early age exposure to moisture damage and systemic inflammation at the age of 6 years

High levels of Butyrate and Propionate in early life are associated with protection against atopy

Immunomodulatory effects of Lactobacillus rhamnosus GG on dendritic cells, macrophages and monocytes from healthy donors

Microbial secondary metabolites in homes in association with moisture damage and asthma

Postprandial glucose metabolism and SCFA after consuming wholegrain rye bread and wheat bread enriched with bioprocessed rye bran in individuals with mild gastrointestinal symptoms

Wild Blueberries (Vaccinium myrtillus) Alleviate Inflammation and Hypertension Associated with Developing Obesity in Mice Fed with a High-Fat Diet

Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome

Ravinto ja suolistomikrobisto

Development and pilot evaluation of a novel probiotic mixture for the management of seasonal allergic rhinitis

Abnormal immunological profile and vaginal microbiota in women prone to urinary tract infections

Effect of bacterial vaginosis, Lactobacillus and premarin estrogen replacement therapy on vaginal gene expression changes

Expression of anti-microbial defence factors in vaginal mucosa following exposure to Lactobacillus rhamnosus GR-1

Anti-inflammatory effects of probiotic yogurt in inflammatory bowel disease patients

Postnatal effects of obstetrical epidural anesthesia on allergic sensitization