Rami Korhonen

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Information Publications

2000: MSc in Medical physics, University of Kuopio, Finland

2004: PhD in Physics, University of Kuopio, Finland

2005-2007: Post doc, University of Calgary, Alberta, Canada

2008-2013: Academy Research Fellow, University of Eastern Finland

2013-2016. Associate Professor of Biomechanics, University of Eastern Finland

2016-current: Professor of Biomechanics

2026-current: Research Professor, Kuopio University Hospital

Dr. Korhonen has vast experience in musculoskeletal biomechanics, imaging and modelling at cellular, molecular, tissue and joint levels. Currently his research aims primarily at 1) revealing new biomechanically and biochemically driven mechanisms leading to osteoarthritis and 2) developing novel imaging and in silico modelling methods for osteoarthritis prognosis and treatment planning. Dr. Korhonen has published around 250 peer-reviewed articles and supervised 35 PhD theses, and his research has been funded by EU (e.g. ERC), Research Council of Finland, Business Finland, and other national and international foundations and organizations.

Links to the BBC research group and MSKHealthTech research community:

Home – Biophysics Research Group

Musculoskeletal Health and Technology (MSKHealthTech) | University of Eastern Finland

Research groups

Biophysics of Bone and Cartilage (BBC) 01.01.1998 -

Publications

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Research groups

Bio‐Compositional and Microstructural Changes in Rabbit Knee Collateral Ligaments Eight Weeks After Anterior Cruciate Ligament Transection

Early Post‑Traumatic Osteoarthritis Features Greater Cartilage Extracellular Matrix Proteoglycan Loss Compared to the Pericellular Matrix

Exploring mechanisms governing cartilage interstitial fluid load support in lubrication through experimental and computational analysis

Interstitial Fluid Load Support in Human Articular Cartilage: Effects of Degeneration, Loading, and Material Properties via Combined Experimental Testing and Computational Modeling

Lower limb muscle activation patterns in response to calf muscle EMG biofeedback before and after an 8-week gait retraining intervention in older adults

MMP release following cartilage injury leads to collagen loss in intact tissue: A computational study

Neural Network-Driven Finite Element Modeling for Estimating Knee Joint Cartilage Mechanical Responses

Personalized musculoskeletal models show that gait biofeedback alters knee cartilage contact mechanics in ACL-reconstructed subjects

The Effects of Surgical Parameters on Meniscal Mechanics Following Anterior Cruciate Ligament Reconstruction: An Exploratory In-Silico Study

Valgus bracing can relocate cartilage contact pressure away from bone marrow lesions and full-thickness cartilage defects in varus-malaligned medial knee osteoarthritis

Valgus bracing reduces cartilage mechanical responses in knees with varus malalignment and medial osteoarthritis: A neuromusculoskeletal–finite element analysis

Acute effects of soleus EMG biofeedback training on tibiofemoral joint contact forces in young healthy adults

An Electromyography-Assisted Musculoskeletal Simulation With Concurrent Optimization of Muscle Excitations and Knee Joint Kinematics

An in silico mechanoregulatory model of depth-dependent adaptations to mechanical loading in intact and damaged cartilage: a proof of concept study

Depth‐Wise Changes in Tibial and Femoral Human Knee Joint Cartilage at Different Severities of Osteoarthritis

Does Valgus Bracing Reduce Estimates of Medial Tibial, Medial Femoral, and Patella Cartilage Contact Pressure in Varus Malaligned Medial Knee Osteoarthritis?

Effect of Uncertainties in Musculoskeletal Modeling Inputs on Sensitivity of Knee Joint Finite Element Simulations

Engineering biomimetic zonal properties in fibre-reinforced hydrogels for functional cartilage tissue engineering in vitro

Exploring the Relationship Between Ligament Microstructure and Mechanics in OA-Affected Human Knees

Generating synthetic images of human skeletal motion for pose and kinematics estimation tasks

Hybrid discrete and finite element analysis enables fast evaluation of hip joint cartilage mechanical response

Insights into patellofemoral kinematics and cartilage stresses following paediatric anterior cruciate ligament reconstruction: An exploratory in silico study

Magnetic resonance imaging provides accurate measures of cartilage creep and biomechanical tissue properties: Ex vivo comparison to ground truth mechanical testing

Mechanobiochemical finite element model to analyze impact-loading-induced cell damage, subsequent proteoglycan loss, and anti-oxidative treatment effects in articular cartilage

Reduced Muscle Strength Can Alter the Impact of Gait Modifications on Knee Cartilage Mechanics

Relationships between anterior cruciate ligament elastic and viscoelastic properties and cartilage degeneration in osteoarthritic human knee joints

Relationships between human patellar tendon and tibial cartilage viscoelastic properties in osteoarthritic knees: an exploratory investigation

Surgical efficacy in paediatric anterior cruciate ligament reconstruction: A comparative 3-case study of actual and simulated surgeries

The human patellar tendon is mechanically homogenous at its mid-substance

Time-dependent computational model of post-traumatic osteoarthritis to estimate how mechanoinflammatory mechanisms impact cartilage aggrecan content

Viscoelastic Properties Of Human Collateral Knee Ligaments Are Related And Altered In Osteoarthritis

Alterations in mechanical properties of rabbit collateral ligaments eight weeks after anterior cruciate ligament transection

An Automated and Robust Tool for Musculoskeletal and Finite Element Modeling of the Knee Joint

Biofeedback-Driven Gait Dynamics Reduces Knee Cartilage Exposure to High Stresses: A Case Study and in Silico Proof-of-Concept in an Acl Reconstructed Patient

Clinical Super-Resolution Computed Tomography of Bone Microstructure: Application in Musculoskeletal and Dental Imaging

Comparison of site-specific tensile, compressive, and friction properties of human tibiofemoral joint cartilage and their relationship to degeneration

Deep learning based detection of osteophytes in radiographs and magnetic resonance imagings of the knee using 2D and 3D morphology

Effect of patient specificity on predicting knee cartilage degeneration in obese adults: Musculoskeletal finite-element modeling of data from the CAROT trial

Gait data from 51 healthy participants with motion capture, inertial measurement units, and computer vision

Independent and combined effects of obesity and traumatic joint injury to the structure and composition of rat knee cartilage

Infrared Spectroscopy Can Differentiate Between Cartilage Injury Models: Implication for Assessment of Cartilage Integrity

Knee-Loading Predictions with Neural Networks Improve Finite Element Modeling Classifications of Knee Osteoarthritis: Data from the Osteoarthritis Initiative

Loss of collagen content is localized near cartilage lesions on the day of injurious loading and intensified on day 12

Muscle Morphology Does Not Solely Determine Knee Flexion Weakness After Anterior Cruciate Ligament Reconstruction with a Semitendinosus Tendon Graft: A Combined Experimental and Computational Modeling Study

Pericellular-to-Extracellular Proteoglycan Content Ratio is Affected in The Mid-Zone Cartilage in Early Post-Traumatic Osteoarthritis

Positive effects of acute N-acetylcysteine treatment simulated by an in silico model with overloading induced cell damage and recovery mechanisms

Predicting Knee Joint Contact Force Peaks During Gait Using a Video Camera or Wearable Sensors

Revealing Detailed Cartilage Function Through Nanoparticle Diffusion Imaging: A Computed Tomography & Finite Element Study

Sensitivity analysis of paediatric knee kinematics to the graft surgical parameters during anterior cruciate ligament reconstruction: A sequentially linked neuromusculoskeletal-finite element analysis

Sensitivity of knee cartilage biomechanics in finite element analysis to selected Musculoskeletal models

Site-specific elastic and viscoelastic biomechanical properties of healthy and osteoarthritic human knee joint articular cartilage

Surgical parameters influence paediatric knee kinematics and cartilage stresses in anterior cruciate ligament reconstruction: Navigating subject-specific variability using neuromusculoskeletal-finite element modelling analysis

Two-Stage Classification of Future Knee Osteoarthritis Severity After 8 Years Using MRI: Data from the Osteoarthritis Initiative

3-D T1 relaxation time measurements in an equine model of subtle post-traumatic osteoarthritis using MB-SWIFT

Automated Tool for Musculoskeletal Finite Element Modeling of Knee

Comparison of constitutive models for meniscus and their effect on the knee joint biomechanics during gait

Contrast Agent Diffusion Reflects Biomechanical Finite Element Model Properties Of Articular Cartilage

Contribution of collagen degradation and proteoglycan depletion to cartilage degeneration in primary and secondary osteoarthritis: an in silico study

Dependence of crack shape in loaded articular cartilage on the collagenous structure

Effects of gait modifications on tissue‐level knee mechanics in individuals with medial tibiofemoral osteoarthritis: A proof‐of‐concept study towards personalized interventions

Injury-related cell death and proteoglycan loss in articular cartilage: Numerical model combining necrosis, reactive oxygen species, and inflammatory cytokines

Knee cartilage mechanics in finite element analysis using inputs from different musculoskeletal software

Load-induced fluid pressurisation in hydrogel systems before and after reinforcement by melt-electrowritten fibrous meshes

Micro-computed Tomography-Based Collagen Orientation and Anisotropy Analysis of Rabbit Articular Cartilage

Microscale investigation of the anisotropic swelling of cartilage tissue and cells in response to hypo-osmotic challenges

Morphology of proximal and distal human semitendinosus compartments and the effects of distal tendon harvesting for anterior cruciate ligament reconstruction

Multiscale In Silico Modeling of Cartilage Injuries

Near-infrared spectroscopic assessment of patellar tendon mechanics

Obesity with ACL transection leads to severe collagen matrix disorganization of knee cartilage in a rat model

Patellar tendon and tibial cartilage viscoelastic properties are inversely related in osteoarthritic knees

Prediction of Knee Joint Compartmental Loading Maxima Utilizing Simple Subject Characteristics and Neural Networks

Sensitivity of simulated knee joint mechanics to selected human and bovine fibril-reinforced poroelastic material properties

Signatures of disease progression in knee osteoarthritis: insights from an integrated multi-scale modeling approach, a proof of concept

Spatial Proteoglycan Content of the Cell Microenvironment is Mostly Affected in the Mid-Zone Cartilage in Very Early Post-Traumatic Osteoarthritis

Towards a Transferable Modeling Method of the Knee to Distinguish Between Future Healthy Joints from Osteoarthritic Joints: Data from the Osteoarthritis Initiative

Triple contrast computed tomography reveals site‐specific biomechanical differences in human knee joint – a proof of concept study

Validation and evaluation of subject-specific finite element models of the pediatric knee