Riikka Martikainen - UEFConnect

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AIVI Stem Cell Center

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ageing disease models mitochondria stem cells

Publications

19/19 items

Heightened sensitivity to adverse effects of metformin in mtDNA mutant patient cells
Ryytty, Sanna; Nurminen, Katriina; Mäkinen, Petri; Suomalainen, Anu; Hämäläinen, Riikka H., 2025, Life sciences, 366-367, 123486. A1 Journal article (refereed), original research
LRRK2 G2019S Mutated iPSC-Derived Endothelial Cells Exhibit Increased α-Synuclein, Mitochondrial Impairment, and Altered Inflammatory Responses
Sonninen, Tuuli-Maria; Peltonen, Sanni; Niskanen, Jonna; Hämäläinen, Riikka H; Koistinaho, Jari; Lehtonen, Šárka, 2024, International journal of molecular sciences, 25, 23, 12874. A1 Journal article (refereed), original research
The Roles of Cystatin B in the Brain and Pathophysiological Mechanisms of Progressive Myoclonic Epilepsy Type 1
Singh, Shekhar; Hämäläinen, Riikka H, 2024, Cells, 13, 2, 170. A2 Review article, Literature review, Systematic review
Generation of a human induced pluripotent stem cell line (UEFi004-A) from a patient with progressive myoclonic epilepsy type 1 (EPM1)
Singh, Shekhar; Plotnikova, Lidiia; Karvonen, Kalle; Ryytty, Sanna; Hyppönen, Jelena; Kälviäinen, Reetta; Hämäläinen, Riikka H., 2023, Stem cell research, 73, 103248. A1 Journal article (refereed), original research
The Mitochondrial m.3243A>G Mutation on the Dish, Lessons from In Vitro Models
Ryytty, Sanna; Hämäläinen, Riikka H, 2023, International journal of molecular sciences, 24, 17, 13478. A2 Review article, Literature review, Systematic review
Functional Characterization of Mechanosensitive Piezo1 Channels in Trigeminal and Somatic Nerves in a Neuron-on-Chip Model
Mikhailov, Nikita; Plotnikova, Lidiia; Singh, Prateek; Giniatullin, Rashid; Hämäläinen, Riikka H., 2022, International journal of molecular sciences, 23, 3, 1370. B1 Non-refereed journal articles
Modulating Mitochondrial DNA Heteroplasmy with Mitochondrially Targeted Endonucleases
Mikhailov, Nikita; Hämäläinen, Riikka H, 2022, Annals of biomedical engineering, [Published 24 August 2022], 1-14. A1 Journal article (refereed), original research
The role of the meningeal lymphatic system in local meningeal inflammation and trigeminal nociception
Mikhailov, Nikita; Virenque, Anaïs; Koroleva, Kseniia; Eme-Scolan, Elisa; Teleman, Matei; Abdollahzadeh, Ali; Giniatullina, Raisa; Gafurov, Oleg; Krivoshein, Georgii; Malm, Tarja; Hämäläinen, Riikka H; Sierra, Alejandra; Tohka, Jussi; Rua, Rejane; Noe, Francesco M; Giniatullin, Rashid, 2022, Scientific reports, 12, 1, 8804. A1 Journal article (refereed), original research
Varied Responses to a High m.3243A>G Mutation Load and Respiratory Chain Dysfunction in Patient-Derived Cardiomyocytes
Ryytty, Sanna; Modi, Shalem R; Naumenko, Nikolay; Shakirzyanova, Anastasia; Rahman, Muhammad Obaidur; Vaara, Miia; Suomalainen, Anu; Tavi, Pasi; Hämäläinen, Riikka H, 2022, Cells, 11, 16, 2593. A1 Journal article (refereed), original research
Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer's disease
Rolova, Taisia; Wu, Ying-Chieh; Koskuvi, Marja; Voutilainen, Jenni; Sonninen, Tuuli-Maria; Kuusisto, Johanna; Laakso, Markku; Hämäläinen, Riikka H; Koistinaho, Jari; Lehtonen, Sárka, 2020, Stem cell research, 48, 101968. A1 Journal article (refereed), original research
Metabolic alterations in Parkinson's disease astrocytes
Sonninen, Tuuli-Maria; Hämäläinen, Riikka H; Koskuvi, Marja; Oksanen, Minna; Shakirzyanova, Anastasia; Wojciechowski, Sara; Puttonen, Katja; Naumenko, Nikolay; Goldsteins, Gundars; Laham-Karam, Nihay; Lehtonen, Marko; Tavi, Pasi; Koistinaho, Jari; Lehtonen, ¦árka, 2020, Scientific reports, 10, 1, 14474. A1 Journal article (refereed), original research
Reply to: Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos
Hämäläinen, Riikka H; Landoni, Juan C; Ahlqvist, Kati J; Goffart, Steffi; Ryytty, Sanna; Rahman, M Obaidur; Brilhante, Virginia; Icay, Katherine; Hautaniemi, Sampsa; Wang, Liya; Laiho, Marikki; Suomalainen, Anu, 2020, Nature metabolism, 2, 8, 676-677. B1 Non-refereed journal articles
NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes
Oksanen, M; Hyötyläinen, I; Trontti, K; Rolova, T; Wojciechowski, S; Koskuvi, M; Viitanen, M; Levonen, AL; Hovatta, I; Roybon, L; Lehtonen, ¦; Kanninen, KM; Hämäläinen, RH; Koistinaho, J, 2019, Glia, 2020; 68, 3, 589-599. A1 Journal article (refereed), original research
Regulation of Mother-to-Offspring Transmission of mtDNA Heteroplasmy
Latorre-Pellicer, Ana; Lechuga-Vieco, Ana Victoria; Johnston, Iain G; Hämäläinen, Riikka H; Pellico, Juan; Justo-Méndez, Raquel; Fernández-Toro, Jose María; Clavería, Cristina; Guaras, Adela; Sierra, Rocío; Llop, Jordi; Torres, Miguel; Criado, Luis Miguel; Suomalainen, Anu; Jones, Nick S; Ruíz-Cabello, Jesús; Enríquez, José Antonio, 2019, Cell metabolism, 30, 6, 1120-1130.e5. A1 Journal article (refereed), original research
Mitochondria: More than Just "Power Plants" in Stem Cells. Call for Papers
Stimpfel Martin, Hämäläinen Riikka H, May-Panloup Pascal, 2017, Stem cells international, 2017, 1826746. B1 Non-refereed journal articles
Aß and Inflammatory Stimulus Activate Diverse Signaling Pathways in Monocytic Cells: Implications in Retaining Phagocytosis in Aß-Laden Environment
Savchenko Ekaterina, Malm Tarja, Konttinen Henna, Hämäläinen Riikka H, Guerrero-Toro Cindy, Wojciechowski Sara, Giniatullin Rashid, Koistinaho Jari, Magga Johanna, 2016, Frontiers in cellular neuroscience, 10, 279. A1 Journal article (refereed), original research
Mitochondria and mtDNA integrity in stem cell function and differentiation
Hämäläinen Riikka, 2016, Current opinion in genetics and development, 38, 83-89. A1 Journal article (refereed), original research
Mitochondrial DNA mutations in iPS cells: mtDNA integrity as standard iPSC selection criteria?
Hämäläinen Riikka H, 2016, Embo journal, 35, 18, 1960-1962. B1 Non-refereed journal articles
Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism
Kettunen Kaisa M, Karikoski Riitta, Hämäläinen Riikka H, Toivonen Teija T, Antonenkov Vasily D, Kulesskaya Natalia, Voikar Vootele, Hölttä-Vuori Maarit, Ikonen Elina, Sainio Kirsi, Jalanko Anu, Karlberg Susann, Karlberg Niklas, Lipsanen-Nyman Marita, Toppari Jorma, Jauhiainen Matti J, Hiltunen Kalervo, Jalanko Hannu, Lehesjoki Anna-Elina, 2016, Biology open, 5, 584-595. A1 Journal article (refereed), original research