Seppo Ylä-Herttuala

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Current Positions

– Professor of Molecular Medicine
– Director of the Biocenter Kuopio
– National Director EU EATRIS-ERIC infrastructure network
– Director of National Virus Vector Laboratory

Research groups

Molecular Medicine 01.01.1995 -

Projects

GeneCellNano Flagship 01.07.2020 - 30.06.2028

- 1987 Ph.D. (Medicine), University of Tampere
- 1982 Licentiate of Medicine, University of Tampere
- 1978 B.Med., University of Tampere
- 2020-2021 Vice Chairman of the ERC Synergy Grant Panel LS7
- 2018-2021 Chairman of Biocenter Finland, University of Helsinki
- 2018-current Board member of the Foundation for Research on Viral Diseases
- 2015-current Associate Editor of Cardiovascular Reserach (Offical Journal of the European Society of Cardiology)
- 2015-2019 Editor-in-Chief of Molecular Therapy (Official Journal of the American Society of Gene and Cell Therapy)
- 2015-2017 Chairman and Board Member, Instrumentarium Science Foundation
- 2014-2016 Chairman, American Society of Gene and Cell Therapy, Cardiovascular Committee
- 2014-2015 Member, American Society of Gene and Cell Therapy, Nominating Committee
- 2012-2013, 2015-2017 Chairman of the ERC consolidated grant panel LS7
- 2011-2017 Chairman and Board Member, Biocenter Oulu, University of Oulu
- 2011-2014 Deputy Member of Board, Institute for Molecular Medicine, University of Helsinki
- 2010-2015 Vice Chairman and Board Member, Instrumentarium Science Foundation
- 2010-2012 Chairman, Biocenter Finland, University of Helsinki
- 2010-2012 President of European Society of Gene and Cell Therapy
- 2008-current Director of Biocenter Kuopio, University of Eastern Finland
- 2005-2020 Academy Professor, Academy of Finland
- 2005-2006 Visiting Professor, Salk Institute, Laboratory of Genetics (Prof. Inder Verma), USA
- 1995- Professor of Molecular Medicine, A.I. Virtanen Institute
- 1992-1995 Senior Research Fellow, Academy of Finland
- 1991-1995 Senior Lecturer in Medical Biochemistry, University of Tampere
- 1991-1992 Junior Research Fellow, Academy of Finland
- 1988-1991 Post-doctoral Fellow, University of California, San Diego, USA (Dr. Daniel Steinberg and Dr. Joseph Witztum)
- 1985-1988 Research Assistant, Academy of Finland
- 1983-1985 Research Associate, University of Tampere

Publications

810/810 items

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Seppo Ylä-Herttuala

Research groups

Projects

Academic Degrees

Major Positions and Appointments

Automated and closed clinical-grade manufacturing protocol produces potent NK cells against neuroblastoma cells and AML blasts

Cancer-type somatic mutations in saccular cerebral aneurysms

Caridac vein retroinjections provide an efficient approach for global left ventricular gene transfer with adenovirus and adeno-associated virus

Cell-Specific Targeting of the Endothelium in the CardioRenal Syndrome

Clinical development and proof of principle testing of new regenerative vascular endothelial growth factor-D therapy for refractory angina: rationale and design of the phase 2 ReGenHeart trial

Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac Hypertrophy

DPYSL5 is highly expressed in treatment-induced neuroendocrine prostate cancer and promotes lineage plasticity via EZH2/PRC2

Deletion of the Murine Ortholog of the Human 9p21.3 Locus Leads to Insulin Resistance and Obesity in Hypercholesterolemic Mice

Efficacy of Intravesical Nadofaragene Firadenovec for Patients With Bacillus Calmette-Guérin–Unresponsive Nonmuscle-Invasive Bladder Cancer: 5-Year Follow-Up From a Phase 3 Trial

Insights into Prime Editing Technology: A Deep Dive into Fundamentals, Potentials and Challenges

Long-term continuous monitoring of arrhythmias in pigs with insertable cardiac monitors

Low dose Adenoviral Vammin gene transfer induces myocardial angiogenesis and increases left ventricular ejection fraction in ischemic porcine heart

Navigating the prime editing strategy to treat cardiovascular genetic disorders in transforming heart health

Optimizing lentiviral vector formulation conditions for efficient ex vivo transduction of primary human T cells in chimeric antigen receptor T-cell manufacturing

SIX2 promotes cell plasticity via Wnt/β-catenin signalling in androgen receptor independent prostate cancer

Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis

Single-cell RNA sequencing analysis identifies acute changes in the tumor microenvironment induced by interferon α gene therapy in a murine bladder cancer model

Synthetic Flavonoid 3,7-Dihydroxy-Isoflav-3-Ene (DHIF) Reduces In-Stent Restenosis in an Atherosclerotic Watanabe Heritable Hyperlipidemic Rabbit Stent Model

The mineralocorticoid receptor in diabetic kidney disease

Translatome profiling reveals Itih4 as a novel smooth muscle cell–specific gene in atherosclerosis

ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling

AAV2 and AAV9 tropism and transgene expression in the mouse eye and major tissues after intravitreal and subretinal delivery

Adenoviral Gene Therapy Vectors in Clinical Use—Basic Aspects with a Special Reference to Replication-Competent Adenovirus Formation and Its Impact on Clinical Safety

Alzheimer's disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs

ApoA-I Nanotherapy Rescues Postischemic Vascular Maladaptation by Modulating Endothelial Cell and Macrophage Phenotypes in Type 2 Diabetic Mice

BMP2 gene transfer induces pericardial effusion and inflammatory response in the ischemic porcine myocardium

COVID-19 adenovirus vector vaccine induces higher interferon and pro-inflammatory responses than mRNA vaccines in human PBMCs, macrophages and moDCs

Capillary Dynamics Regulate Post-Ischemic Muscle Damage and Regeneration in Experimental Hindlimb Ischemia

Characterization of a new IN-I-PpoI fusion protein and a homology-arm containing transgene cassette that improve transgene expression persistence and 28S rRNA gene-targeted insertion of lentiviral vectors

Comparison of Automated and Traditional Western Blotting Methods

Critical limb-threatening ischemia and microvascular transformation: clinical implications

Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity

Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures

ErbB signalling is a potential therapeutic target for vascular lesions with fibrous component

Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System

Geeniterapia avaa uusia virtsarakkosyövän hoitomahdollisuuksia

Gene Therapeutic Strategies for Peripheral Artery Disease and New Opportunities Provided by Adeno-Associated Virus Vectors

Hypoxic regulation of hypoxia inducible factor 1 alpha via antisense transcription

Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models

Lymphatic insufficiency leads to distinct myocardial infarct content assessed by magnetic resonance TRAFFn, T1ρ and T2 relaxation times

New Twist in Cell Therapy for the Treatment of Severe Ischemia

Proangiogenic Growth Factor Therapy for the Treatment of Refractory Angina: A Meta-analysis

Role of non-coding RNAs in physiological and pathological angiogenesis

SproutAngio: an open-source bioimage informatics tool for quantitative analysis of sprouting angiogenesis and lumen space

Using the Jurkat reporter T cell line for evaluating the functionality of novel chimeric antigen receptors

AAV2-VEGF-B gene therapy failed to induce angiogenesis in ischemic porcine myocardium due to inflammatory responses

AAV8-mediated sVEGFR2 and sVEGFR3 gene therapy combined with chemotherapy reduces the growth and microvasculature of human ovarian cancer and prolongs the survival in mice

Adenoviral VEGF-DΔN ΔC gene therapy for myocardial ischemia

Antiadenovirus Antibodies Predict Response Durability to Nadofaragene Firadenovec Therapy in BCG-unresponsive Non-muscle-invasive Bladder Cancer: Secondary Analysis of a Phase 3 Clinical Trial

Antiangiogenic AAV2 gene therapy with a truncated form of soluble VEGFR-2 reduces the growth of choroidal neovascularization in mice after intravitreal injection

Decreased Gray–White Matter Contrast of [11C]-PiB Uptake in Cognitively Unimpaired Subjects with Severe Obstructive Sleep Apnea

Endocardial Gene Delivery Using NOGA Catheter System

Intramyocardial adenoviral vascular endothelial growth factor‐D∆N∆C gene therapy does not induce ventricular arrhythmias

Lentiviral interferon: A novel method for gene therapy in bladder cancer

Novel Designed Proteolytically Resistant VEGF-B186R127S Promotes Angiogenesis in Mouse Heart by Recruiting Endothelial Progenitor Cells

Novel modular chimeric antigen receptor spacer for T cells derived from signal regulatory protein alpha Ig-like domains

Nuclear microRNA-466c regulates Vegfa expression in response to hypoxia

Optimized riboswitch-regulated AAV vector for VEGF-B gene therapy

Preclinical Evaluation of Coronary Artery Stents

RNA interference-based therapies for the control of atherosclerosis risk factors

Rapid high-throughput compatible label-free virus particle quantification method based on time-resolved luminescence

Strategies to improve safety profile of AAV vectors

Therapeutic Potential of VEGF-B in Coronary Heart Disease and Heart Failure: Dream or Vision?

Translational opportunities of single-cell biology in atherosclerosis

Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta

Adenoviral VEGF-B186R127S gene transfer induces angiogenesis and improves perfusion in ischemic heart

Arterial Gene Transfer With Lentivirus Vectors: The Jury is Still Out

Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis

Citrate-saline formulated mRNA delivery into the heart muscle with an electromechanical mapping and injection catheter does not lead to therapeutic effects in a porcine chronic myocardial ischemia model

Computed tomography coronary angiography for patients with heart failure (CTA-HF): a randomized controlled trial (IMAGE-HF 1C)

Cyclo-oxygenase 2, a putative mediator of vessel remodeling, is expressed in the brain AVM vessels and associates with inflammation

Efficacy and Safety of Clinical Grade hVEGF-D [delta]N[delta]C Gene Therapy Containing Residual Replication-Competent Adenoviruses

Epigenetic Regulation of Vascular Smooth Muscle Cell Phenotype Switching in Atherosclerotic Artery Remodeling: A Mini-Review

Evaluation of glucagon-like peptide-1 receptor expression in nondiabetic and diabetic atherosclerotic mice using PET tracer 68Ga-NODAGA-exendin-4