Steffi Goffart

Tailoring carbon nitride nanoarchitecture and cellular interactions through hydrothermal alkaline etching

Belko, Nikita; Maltanava, Hanna; Nardone, Emanuele; Goffart, Steffi; Adigun, Deborah Amos; Tamarov, Konstantin; Leskinen, Jari TT; Zalieckas, Martynas; Karpicz, Renata; Halimski, Ivan; Kuivalainen, Jarkko; Mäkinen, Petri; Lehto, Vesa-Pekka; Lähderanta, Erkki; De Vos, Winnok H; Kuzhir, Polina, 2026, Journal of materials chemistry. b, [First published: 13 October 2026], 1-13. A1 Journal article (refereed), original research

Vitamin B12 Availability and Interaction with Bacterium Mesorhizobium loti Affect Growth and Biochemical Composition of Mixotrophic Alga Euglena Gracilis

Ghimire, Sadikshya; Sohrabi, Mohammad Salar; Zhou, Xuan; Malinen, Marjo; Keinänen, Markku; Goffart, Steffi; Keski-Saari, Sarita; Strandberg, Ursula, 2026, Microbial ecology, 89, 169. A1 Journal article (refereed), original research

Chromosome-level reference genome assembly for the mountain hare (Lepus timidus)

Fekete, Zsófia; Absolon, Dominic E.; Michell, Craig; Wood, Jonathan M.D.; Goffart, Steffi; Pohjoismäki, Jaakko L.O., 2025, Peer community journal, 5, e14. A1 Journal article (refereed), original research

Exploring mitonuclear interactions in the regulation of cell physiology: insights from interspecies cybrids

Gaertner, Kateryna; Tapanainen, Riikka; Saari, Sina; Fekete, Zsófia; Goffart, Steffi; Pohjoismäki, Jaakko LO; Dufour, Eric, 2025, Experimental cell research, 446, 2, 114466. A1 Journal article (refereed), original research

MRE11-independent effects of Mirin on mitochondrial DNA integrity and cellular immune responses

Aasumets, Koit; Hangas, Anu; Fragkoulis, Georgios; Bader, Cyrielle PJ; Erdinc, Direnis; Wanrooij, Sjoerd; Wanrooij, Paulina H; Goffart, Steffi; Pohjoismäki, Jaakko LO, 2025, Molecular biology of the cell, 36, 2, 1-11. A1 Journal article (refereed), original research

The POLγ Y951N patient mutation disrupts the switch between DNA synthesis and proofreading, triggering mitochondrial DNA instability

Forslund, Josefin M. E.; Nguyen, Tran V. H.; Parkash, Vimal; Berner, Andreas; Goffart, Steffi; Pohjoismäki, Jaakko L. O.; Wanrooij, Paulina H.; Johansson, Erik; Wanrooij, Sjoerd, 2025, Proceedings of the National Academy of Sciences of the United States of America, 122, 16, e2417477122. A1 Journal article (refereed), original research

High quality genome assembly of the brown hare (Lepus europaeus) with chromosome-level scaffolding

Michell, Craig; Collins, Joanna; Laine, Pia K; Fekete, Zsófia; Tapanainen, Riikka; Wood, Jonathan M D; Goffart, Steffi; Pohjoismäki, Jaakko L O, 2024, Peer community journal, 4, e26. A1 Journal article (refereed), original research

Linear DNA-driven recombination in mammalian mitochondria

Fragkoulis, Georgios; Hangas, Anu; Fekete, Zsófia; Michell, Craig; Moraes, Carlos T; Willcox, Smaranda; Griffith, Jack D; Goffart, Steffi; Pohjoismäki, Jaakko L O, 2024, Nucleic acids research, 52, 6, 3088-3105. A1 Journal article (refereed), original research

Overactive mitochondrial DNA replication disrupts perinatal cardiac maturation

Landoni, Juan C; Erkul, Semin; Laalo, Tuomas; Goffart, Steffi; Kivelä, Riikka; Skube, Karlo; Nieminen, Anni I; Wickström, Sara A; Stewart, James; Suomalainen, Anu, 2024, Nature communications, 15, 1, 8066. A1 Journal article (refereed), original research

Species-specific variation in mitochondrial genome tandem repeat polymorphisms in hares (Lepus spp., Lagomorpha, Leporidae) provides insight into their evolution

Tapanainen, Riikka; Aasumets, Koit; Fekete, Zsófia; Goffart, Steffi; Dufour, Eric; LO Pohjoismäki, Jaakko, 2024, Gene, 926, 148644. A1 Journal article (refereed), original research

Analysis of Mitochondrial DNA Replication by Two-Dimensional Agarose Gel Electrophoresis

Goffart, Steffi; Pohjoismäki, Jaakko, 2023, Nicholls, TJ; Uhler, JP; Falkenberg, M, Mitochondrial DNA, 241-266. A3 Book section, Chapters in research books

Uncharacterized protein C17orf80 - a novel interactor of human mitochondrial nucleoids

Potter, Alisa; Hangas, Anu; Goffart, Steffi; Huynen, Martijn A; Cabrera-Orefice, Alfredo; Spelbrink, Johannes N, 2023, Journal of cell science, 136, 15, jcs260822. A1 Journal article (refereed), original research

Adaptive and Pathological Outcomes of Radiation Stress-Induced Redox Signaling

Pohjoismäki, Jaakko LO; Goffart, Steffi, 2022, Antioxidants and redox signaling, 37, 4-6, 336-348. A1 Journal article (refereed), original research

Draft Genome Sequence of Bradyrhizobium denitrificans K2, Cultivated from an Air Ventilation Environment

Paul, Dhiraj; Paasisalo, Inga; Katainen, Markku; Goffart, Steffi; Pumpanen, Jukka; Siljanen, Henri M. P., 2022, Microbiology resource announcements, 11, 12, e0090722. B1 Non-refereed journal articles

Heterozygous p.Y955C mutation in DNA polymerase γ leads to alterations in bioenergetics, complex I subunit expression, and mtDNA replication

Rahman, Md. Mostafijur; Young, Carolyn K.J; Goffart, Steffi; Pohjoismäki, Jaakko L.O; Young, Matthew J, 2022, Journal of biological chemistry, 298, 8, 102196. A1 Journal article (refereed), original research

Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha: Leporidae)

Gaertner, Kateryna; Michell, Craig; Tapanainen, Riikka; Goffart, Steffi; Saari, Sina; Soininmäki, Manu; Dufour, Eric; Pohjoismäki, Jaakko LO, 2022, Molecular ecology, 32, 15, 4097-4117. A1 Journal article (refereed), original research

Top3α is the replicative topoisomerase in mitochondrial DNA replication

Hangas, Anu; Kekäläinen, Nina J; Potter, Alisa; Michell, Craig; Aho, Kauko J; Rutanen, Chiara; Spelbrink, Johannes N; Pohjoismäki, Jaakko L; Goffart, Steffi, 2022, Nucleic acids research, 50, 15, 8733-8748. A1 Journal article (refereed), original research

MRE11-dependent instability in mitochondrial DNA fork protection activates a cGAS immune signaling pathway

Luzwick, Jessica W.; Dombi, Eszter; Boisvert, Rebecca A.; Roy, Sunetra; Park, Soyoung; Kunnimalaiyaan, Selvi; Goffart, Steffi; Schindler, Detlev; Schlacher, Katharina, 2021, Science advances, 7, 51, eabf9441. A1 Journal article (refereed), original research

TFAM knockdown-triggered mtDNA-nucleoid aggregation and a decrease in mtDNA copy number induce the reorganization of nucleoid populations and mitochondria-associated ER-membrane contacts

Aasumets, Koit; Basikhina, Yuliya; Pohjoismäki, Jaakko L; Goffart, Steffi; Gerhold, Joachim, 2021, Biochemistry and biophysics reports, 28, 101142. A1 Journal article (refereed), original research

The Type and Source of Reactive Oxygen Species Influences the Outcome of Oxidative Stress in Cultured Cells

Goffart, S; Tikkanen, P; Michell, C; Wilson, T; Pohjoismäki, JLO, 2021, Cells, 10, 5, 1075. A1 Journal article (refereed), original research

Reply to: Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos

Hämäläinen, Riikka H; Landoni, Juan C; Ahlqvist, Kati J; Goffart, Steffi; Ryytty, Sanna; Rahman, M Obaidur; Brilhante, Virginia; Icay, Katherine; Hautaniemi, Sampsa; Wang, Liya; Laiho, Marikki; Suomalainen, Anu, 2020, Nature metabolism, 2, 8, 676-677. B1 Non-refereed journal articles

Defects in mtDNA replication challenge nuclear genome stability through nucleotide depletion and provide a unifying mechanism for mouse progerias

Hämäläinen, Riikka H; Landoni, Juan C; Ahlqvist, Kati J; Goffart, Steffi; Ryytty, Sanna; Rahman, M Obaidur; Brilhante, Virginia; lcay, Katherine; Hautaniemi, Sampsa; Wang, Liya; Laiho, Marikki; Suomalainen, Anu, 2019, Nature metabolism, 1, 958-965. A1 Journal article (refereed), original research

Hydraulically pressed silver nanowire-cotton fibers as an active platform for filtering and surface-enhanced Raman scattering detection of bacteria from fluid

Ankudze, Bright; Asare, Bismark; Goffart, Steffi; Koistinen, Arto; Nuutinen, Tarmo; Matikainen, Antti; Andoh, Sampson Saj; Roussey, Matthieu;, Pakkanen, Tuula. T, 2019, Applied surface science, 479, 663-668. A1 Journal article (refereed), original research

Replication fork rescue in mammalian mitochondria

Torregrosa-Muñumer, R; Hangas, A; Goffart, S; Blei, D; Zsurka, G; Griffith, J; Kunz ,WS; Pohjoismäki, JLO, 2019, Scientific reports, 9, 1, 8785. A1 Journal article (refereed), original research

Twist and Turn - Topoisomerase Functions in Mitochondrial DNA Maintenance

Goffart, S; Hangas, A; Pohjoismäki, JLO, 2019, International journal of molecular sciences, 20, 8, 2041. A2 Review article, Literature review, Systematic review

ATAD3 controls mitochondrial cristae structure, influencing mtDNA replication and cholesterol levels in muscle

Peralta, Susana; Goffart, Steffi; Williams, Sion L; Diaz, Francisca; Garcia, Sofia; Nissanka, Nadee; Area-Gomez, Estela; Pohjoismäki, Jaakko; Moraes, Carlos T, 2018, Journal of cell science, 131, jcs217075. A1 Journal article (refereed), original research

Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2

Hangas, Anu; Aasumets, Koit; Kekäläinen, Nina J; Paloheinä, Mika; Pohjoismäki, Jaakko L; Gerhold, Joachim M; Goffart, Steffi, 2018, Nucleic acids research, 46, 18, 9625-9636. A1 Journal article (refereed), original research

Known Unknowns of Mammalian Mitochondrial DNA Maintenance

Pohjoismäki, Jaakko LO; Forslund, Josefin ME; Goffart, Steffi; Torregrosa-Muñumer, Ruben; Wanrooij, Sjoerd, 2018, Bioessays, 40, 9, 1800102. A2 Review article, Literature review, Systematic review

Preclinical Efficacy and Safety Evaluation of Hematopoietic Stem Cell Gene Therapy in a Mouse Model of MNGIE

Yadak, Rana; Cabrera-Pérez, Raquel; Torres-Torronteras, Javier; Bugiani, Marianna; Haeck, Joost C; Huston, Marshall W; Bogaerts, Elly; Goffart, Steffi; Jacobs, Edwin H; Stok, Merel; Leonardelli, Lorena; Biasco, Luca; Verdijk, Robert M; Bernsen, Monique R; Ruijter, George; Martí, Ramon; Wagemaker, Gerard; van Til, Niek P; de Coo, Irenaeus FM, 2018, Molecular therapy : methods & clinical development, 8, 152-165. A1 Journal article (refereed), original research

Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alfa/beta-hydrolase domain containing 11 (ABHD11)

Navia-Paldanius D, Patel JZ, López Navarro M, Jakupovic H, Goffart S, Pasonen-Seppänen S, Nevalainen TJ, Jääskeläinen T, Laitinen T, Laitinen JT, Savinainen JR, 2016, European journal of pharmaceutical sciences, 93, 253-263. A1 Journal article (refereed), original research

Low doses of ultraviolet radiation and oxidative damage induce dramatic accumulation of mitochondrial DNA replication intermediates, fork regression, and replication initiation shift

Torregrosa-Muñumer Ruben, Goffart Steffi, Haikonen Juha A, Pohjoismäki Jaakko LO, 2015, Molecular biology of the cell, 26, 23, 4197-4208. A1 Journal article (refereed), original research

Binding to G-quadruplex RNA activates the mitochondrial GTPase NOA1

Al-Furoukh Natalie, Goffart Steffi, Szibor Marten, Wanrooij Sjoerd, Braun Thomas, 2013, Biochimica et biophysica acta: molecular cell research, 1833, 12, 2933-2942. A1 Journal article (refereed), original research

Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species

Pohjoismäki JL, Williams SL, Boettger T, Goffart S, Kim J, Suomalainen A, Moraes CT, Braun T, 2013, Proceedings of the National Academy of Sciences of the United States of America, [Epub ahead of print], x-x. A1 Journal article (refereed), original research

Oxidative stress during mitochondrial biogenesis compromises mtDNA integrity in growing hearts and induces a global DNA repair response

Pohjoismäki JL, Boettger T, Liu Z, Goffart S, Szibor M, Braun T, 2012, Nucleic acids research, 40, 14, 6595-607. A1 Journal article (refereed), original research

Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA.

Dalla Rosa I, Goffart S, Wurm M, Wiek C, Essmann F, Sobek S, Schroeder P, Zhang H, Krutmann J, Hanenberg H, Schulze-Osthoff K, Mielke C, Pommier Y, Boege F, Christensen MO., 2009, Nucleic acids research, 37, 19, 6414-28. A1 Journal article (refereed), original research

Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells.

Pohjoismäki JL, Wanrooij S, Hyvärinen AK, Goffart S, Holt IJ, Spelbrink JN, Jacobs HT, 2006, Nucleic acids research, 34, 20, 5815-28. A1 Journal article (refereed), original research

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Tailoring carbon nitride nanoarchitecture and cellular interactions through hydrothermal alkaline etching

Vitamin B12 Availability and Interaction with Bacterium Mesorhizobium loti Affect Growth and Biochemical Composition of Mixotrophic Alga Euglena Gracilis

Chromosome-level reference genome assembly for the mountain hare (Lepus timidus)

Exploring mitonuclear interactions in the regulation of cell physiology: insights from interspecies cybrids

MRE11-independent effects of Mirin on mitochondrial DNA integrity and cellular immune responses

The POLγ Y951N patient mutation disrupts the switch between DNA synthesis and proofreading, triggering mitochondrial DNA instability

High quality genome assembly of the brown hare (Lepus europaeus) with chromosome-level scaffolding

Linear DNA-driven recombination in mammalian mitochondria

Overactive mitochondrial DNA replication disrupts perinatal cardiac maturation

Species-specific variation in mitochondrial genome tandem repeat polymorphisms in hares (Lepus spp., Lagomorpha, Leporidae) provides insight into their evolution

Analysis of Mitochondrial DNA Replication by Two-Dimensional Agarose Gel Electrophoresis

Uncharacterized protein C17orf80 - a novel interactor of human mitochondrial nucleoids

Adaptive and Pathological Outcomes of Radiation Stress-Induced Redox Signaling

Draft Genome Sequence of Bradyrhizobium denitrificans K2, Cultivated from an Air Ventilation Environment

Heterozygous p.Y955C mutation in DNA polymerase γ leads to alterations in bioenergetics, complex I subunit expression, and mtDNA replication

Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha: Leporidae)

Top3α is the replicative topoisomerase in mitochondrial DNA replication

MRE11-dependent instability in mitochondrial DNA fork protection activates a cGAS immune signaling pathway

TFAM knockdown-triggered mtDNA-nucleoid aggregation and a decrease in mtDNA copy number induce the reorganization of nucleoid populations and mitochondria-associated ER-membrane contacts

The Type and Source of Reactive Oxygen Species Influences the Outcome of Oxidative Stress in Cultured Cells

Reply to: Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos

Defects in mtDNA replication challenge nuclear genome stability through nucleotide depletion and provide a unifying mechanism for mouse progerias

Hydraulically pressed silver nanowire-cotton fibers as an active platform for filtering and surface-enhanced Raman scattering detection of bacteria from fluid

Replication fork rescue in mammalian mitochondria

Twist and Turn - Topoisomerase Functions in Mitochondrial DNA Maintenance

ATAD3 controls mitochondrial cristae structure, influencing mtDNA replication and cholesterol levels in muscle

Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2

Known Unknowns of Mammalian Mitochondrial DNA Maintenance

Preclinical Efficacy and Safety Evaluation of Hematopoietic Stem Cell Gene Therapy in a Mouse Model of MNGIE

Tissue specific differences in mitochondrial DNA maintenance and expression

PrimPol is required for replication reinitiation after mtDNA damage

The role of mitochondria in cardiac development and protection

Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alfa/beta-hydrolase domain containing 11 (ABHD11)

Low doses of ultraviolet radiation and oxidative damage induce dramatic accumulation of mitochondrial DNA replication intermediates, fork regression, and replication initiation shift

Binding to G-quadruplex RNA activates the mitochondrial GTPase NOA1

Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species

Oxidative stress during mitochondrial biogenesis compromises mtDNA integrity in growing hearts and induces a global DNA repair response

Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA.

Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells.