Steroid Receptor Research Center
Research group
01.01.2019 -
Institute of Biomedicine, School of Medicine, Faculty of Health Sciences
Leaders
We study the functions of steroid receptors especially in regulation of chromatin and transcription, and the role of these in hormone-driven cancers. Especially, we focus on formation of drug resistance in especially prostate cancer.
Currently, there are five research groups in the SRRC which are led by Prof. Jorma Palvimo, Research Director Leena Latonen, University lecturer Einari Niskanen, and Academy researchers Kirsi Ketola and Ville Paakinaho.
Cooperation
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Cancer Cell Plasticity - Ketola Lab 01.09.2019 - -
Cancer stress biology - Latonen Lab 01.01.2019 - -
Steroid Receptors and SUMO Modifications in the Regulation of Gene Networks and Cellular Plasticity 01.01.2022 - -
Regulatory mechanisms of steroid receptors - Niskanen lab 01.09.2020 - -
Transcription factor crosstalk in cancers - Paakinaho lab 01.01.2022 -
Leaders
Senior Researchers
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Leena Latonen
Research DirectorInstitute of Biomedicine, School of Medicine, Faculty of Health Sciences -
Kirsi Ketola
Research DirectorInstitute of Biomedicine, School of Medicine, Faculty of Health Sciences -
Ville Paakinaho
Academy Research FellowInstitute of Biomedicine, School of Medicine, Faculty of Health Sciences -
Einari A. Niskanen
University LecturerInstitute of Biomedicine, School of Medicine, Faculty of Health Sciences
Publications
39 items-
A Multi-Stain Breast Cancer Histological Whole-Slide-Image Data Set from Routine Diagnostics
Weitz, Philippe; Valkonen, Masi; Solorzano, Leslie; Carr, Circe; Kartasalo, Kimmo; Boissin, Constance; Koivukoski, Sonja; Kuusela, Aino; Rasic, Dusan; Feng, Yanbo; Sinius Pouplier, Sandra; Sharma, Abhinav; Ledesma Eriksson, Kajsa; Latonen, Leena; Laenkholm, Anne-Vibeke; Hartman, Johan; Ruusuvuori, Pekka; Rantalainen, Mattias. 2023. Scientific data. 10: . 562 A1 Journal article (refereed), original research -
Complementary analysis of proteome‐wide proteomics reveals changes in RNA binding protein‐profiles during prostate cancer progression
Aikio, Erika; Koivukoski, Sonja; Kallio, Elina; Sadeesh, Nithin; Niskanen, Einari A; Latonen, Leena. 2023. Cancer reports. 6: A1 Journal article (refereed), original research -
Deformation equivariant cross-modality image synthesis with paired non-aligned training data
Honkamaa, Joel; Khan, Umair; Koivukoski, Sonja; Valkonen, Mira; Latonen, Leena; Ruusuvuori, Pekka; Marttinen, Pekka. 2023. Medical image analysis. 90: A1 Journal article (refereed), original research -
Dynamic switching of transcriptional regulators between two distinct low-mobility chromatin states
Wagh, Kaustubh; Stavreva, Diana A.; Jensen, Rikke A. M.; Paakinaho, Ville; Fettweis, Gregory; Schiltz, R. Louis; Wüstner, Daniel; Mandrup, Susanne; Presman, Diego M.; Upadhyaya, Arpita; Hager, Gordon L.. 2023. Science advances. 9: . ade1122 A1 Journal article (refereed), original research -
Identification of long noncoding RNAs with aberrant expression in prostate cancer metastases
Sattari, Mina; Kohvakka, Annika; Moradi, Elaheh; Rauhala, Hanna; Urhonen, Henna; Isaacs, William B; Nykter, Matti; Murtola, Teemu J; Tammela, Teuvo L. J.; Latonen, Leena; Bova, G. Steven; Kesseli, Juha; Visakorpi, Tapio. 2023. Endocrine-related cancer. 30: A1 Journal article (refereed), original research -
International Online Team-Based Learning in Higher Education of Biomedicine - Evaluation by Learning Analytics
Mairinoja, Laura; López-Pernas, Sonsoles; Elmoazen, Ramy; Niskanen, Einari A.; Kuningas, Tiina; Wärri, Anni; Saqr, Mohammed; Strauss, Leena. Teoksessa: Elmoazen, Ramy; López-Pernas, Sonsoles; Misiejuk, Kamila; Khalil, Mohammad; Wasson, Barbara; Saqr, Mohammed(toim.) , 2023. Proceedings of the Technology-Enhanced Learning in Laboratories Workshop (TELL 2023). s. 49-60. A4 Conference proceedings -
The effect of neural network architecture on virtual H&E staining: Systematic assessment of histological feasibility
Khan, Umair; Koivukoski, Sonja; Valkonen, Mira; Latonen, Leena; Ruusuvuori, Pekka. 2023. Patterns. 4: A1 Journal article (refereed), original research -
Unstained Tissue Imaging and Virtual Hematoxylin and Eosin Staining of Histologic Whole Slide Images
Koivukoski, Sonja; Khan, Umair; Ruusuvuori, Pekka; Latonen, Leena. 2023. Laboratory investigation. 103: A1 Journal article (refereed), original research -
Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion
Tollis, Sylvain; Rizzotto, Andrea; Pham, Nhan T; Koivukoski, Sonja; Sivakumar, Aishwarya; Shave, Steven; Wildenhain, Jan; Zuleger, Nikolaj; Keys, Jeremy T; Culley, Jayne; Zheng, Yijing; Lammerding, Jan; Carragher, Neil O; Brunton, Valerie G; Latonen, Leena; Auer, Manfred; Tyers, Mike; Schirmer, Eric C. 2022. Acs chemical biology. 17: 680-700 A1 Journal article (refereed), original research -
M1 Macrophages Induce Protumor Inflammation in Melanoma Cells through TNFR–NF-κB Signaling
Kainulainen, Kirsi; Takabe, Piia; Heikkinen, Sami; Aaltonen, Niina; de la Motte, Carol; Rauhala, Leena; Durst, Franziska C; Oikari, Sanna; Hukkanen, Taija; Rahunen, Eija; Ikonen, Ella; Hartikainen, Jaana M; Ketola, Kirsi; Pasonen-Seppänen, Sanna. 2022. Journal of investigative dermatology. 1412: 3041-3051.e10 A1 Journal article (refereed), original research