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Teemu Kuulasmaa

Teemu Kuulasmaa

Hourly Employee

Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences

[email protected]

Information Publications

Publications

52/52 items

Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease
European Alzheimer’s & Dementia Biobank Mendelian Randomization (EADB-MR) Collaboration, 2023, JAMA network open, 6, 5, e2313734. A1 Journal article (refereed), original research
Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
Le Guen, Yann; Luo, Guo; Ambati, Aditya; Damotte, Vincent; Jansen, Iris; Yu, Eric; Nicolas, Aude; de Rojas, Itziar; Peixoto Leal, Thiago; Miyashita, Akinori; Bellenguez, Céline; Lian, Michelle Mulan; Parveen, Kayenat; Morizono, Takashi; Park, Hyeonseul; Grenier-Boley, Benjamin; Naito, Tatsuhiko; Küçükali, Fahri; Talyansky, Seth D.; Yogeshwar, Selina Maria; Sempere, Vicente; Satake, Wataru; Alvarez, Victoria; Arosio, Beatrice; Belloy, Michael E.; Benussi, Luisa; Boland, Anne; Borroni, Barbara; Bu, 2023, Proceedings of the National Academy of Sciences of the United States of America, 120, 36, e2302720120. A1 Journal article (refereed), original research
Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models
Wittrahm, Rebekka; Takalo, Mari; Kuulasmaa, Teemu; Mäkinen, Petra M; Mäkinen, Petri; Končarević, Saša; Fartzdinov, Vadim; Selzer, Stefan; Kokkola, Tarja; Antikainen, Leila; Martiskainen, Henna; Kemppainen, Susanna; Marttinen, Mikael; Jeskanen, Heli; Rostalski, Hannah; Rahunen, Eija; Kivipelto, Miia; Ngandu, Tiia; Natunen, Teemu; Lambert, Jean-Charles; Tanzi, Rudolph E; Kim, Doo Yeon; Rauramaa, Tuomas; Herukka, Sanna-Kaisa; Soininen, Hilkka; Laakso, Markku; Pike, Ian; Leinonen, Ville; Haapasalo,, 2023, Neurobiology of disease, 182, 106140. A1 Journal article (refereed), original research
Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers
Jansen, Iris E.; van der Lee, Sven J.; Gomez-Fonseca, Duber; de Rojas, Itziar; Dalmasso, Maria Carolina; Grenier-Boley, Benjamin; Zettergren, Anna; Mishra, Aniket; Ali, Muhammad; Andrade, Victor; Bellenguez, Céline; Kleineidam, Luca; Küçükali, Fahri; Sung, Yun Ju; Tesí, Niccolo; Vromen, Ellen M.; Wightman, Douglas P.; Alcolea, Daniel; Alegret, Montserrat; Alvarez, Ignacio; Amouyel, Philippe; Athanasiu, Lavinia; Bahrami, Shahram; Bailly, Henri; Belbin, Olivia; Bergh, Sverre; Bertram, Lars; Biesse, 2022, Acta neuropathologica, 144, 5, 821-842. A1 Journal article (refereed), original research
New insights into the genetic etiology of Alzheimer’s disease and related dementias
Bellenguez, Céline; Küçükali, Fahri; Jansen, Iris E.; Kleineidam, Luca; Moreno-Grau, Sonia; Amin, Najaf; Naj, Adam C.; Campos-Martin, Rafael; Grenier-Boley, Benjamin; Andrade, Victor; Holmans, Peter A.; Boland, Anne; Damotte, Vincent; van der Lee, Sven J.; Costa, Marcos R.; Kuulasmaa, Teemu; Yang, Qiong; de Rojas, Itziar; Bis, Joshua C.; Yaqub, Amber; Prokic, Ivana; Chapuis, Julien; Ahmad, Shahzad; Giedraitis, Vilmantas; Aarsland, Dag; Garcia-Gonzalez, Pablo; Abdelnour, Carla; Alarcón-Martín, Em, 2022, Nature genetics, 54, 4, 412-436. A1 Journal article (refereed), original research
A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population
Rostalski, H; Korhonen, V; Kuulasmaa, T; Solje, E; Krüger, J; Gen, F; Kaivola, K; Eide, PK; Lambert, JC; Julkunen, V; Tienari, PJ; Remes, AM; Leinonen, V; Hiltunen, M; Haapasalo, A, 2021, Journal of Alzheimer's disease, 83, 3, 1325-1332. A1 Journal article (refereed), original research
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
de Rojas, I; Moreno-Grau, S; Tesi, N; Grenier-Boley, B; Andrade, V; Jansen, IE; Pedersen, NL; Stringa, N; Zettergren, A; Hernández, I; Montrreal, L; Antúnez, C; Antonell, A; Tankard, RM; Bis, JC; Sims, R; Bellenguez, C; Quintela, I; González-Perez, A; Calero, M; et al; [incl. Haapasalo, A; Soininen, H; Lehtisalo, J; Kivipelto, M; Kuulasmaa, T; Hiltunen, M], 2021, Nature communications, 12, 1, 3417. A1 Journal article (refereed), original research
Isoflurane affects brain functional connectivity in rats 1 month after exposure
Stenroos, Petteri; Pirttimäki, Tiina; Paasonen, Jaakko; Paasonen, Ekaterina; Salo, Raimo A; Koivisto, Hennariikka; Natunen, Teemu; Mäkinen, Petra; Kuulasmaa, Teemu; Hiltunen, Mikko; Tanila, Heikki; Gröhn, Olli, 2021, Neuroimage, 234, 117987. A1 Journal article (refereed), original research
MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation
Wittrahm, Rebekka; Takalo, Mari; Marttinen, Mikael; Kuulasmaa, Teemu; Mäkinen, Petra; Kemppainen, Susanna; Martiskainen, Henna; Rauramaa, Tuomas; Pike, Ian; Leinonen, Ville; Natunen, Teemu; Haapasalo, Annakaisa; Hiltunen, Mikko, 2021, Cells, 10, 4, 860. A1 Journal article (refereed), original research
Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT: An IMI DIRECT study
Tura, Andrea; Grespan, Eleonora; Göbl, Christian S; Koivula, Robert W; Franks, Paul W; Pearson, Ewan R; Walker, Mark; Forgie, Ian M; Giordano, Giuseppe N; Pavo, Imre; Ruetten, Hartmut; Dermitzakis, Emmanouil T; McCarthy, Mark I; Pedersen, Oluf; Schwenk, Jochen M; Adamski, Jerzy; De Masi, Federico; Tsirigos, Konstantinos D; Brunak, Søren; Viñuela, Ana et al. [incl. Kokkola, Tarja; Vangipurapu Jagadish; Laakso, Markku; Kuulasmaa, Teemu], 2021, Diabetes, 70, 96, 2092-2106. A1 Journal article (refereed), original research
The association of nine amino acids with cardiovascular events in Finnish men in a 12-year follow-up study
Jauhiainen, Raimo; Vangipurapu, Jagadish; Laakso, Annamaria; Kuulasmaa, Teemu; Kuusisto, Johanna; Laakso, Markku, 2021, Journal of clinical endocrinology and metabolism, 106, 12, 3448-3454. A1 Journal article (refereed), original research
The trans-ancestral genomic architecture of glycemic traits
Chen, J; Spracklen, CN; Marenne, G; Varshney, A; Corbin, LJ; Luan, J; Willems, SM; Wu, Y; Zhang, X; Horikoshi, M; Boutin, TS; Mägi, R; Waage, J; Li-Gao, R; Chan, KHK; Yao, J; Anasanti, MD; Chu, AY; Claringbould, A; Heikkinen, J; et al. [incl. Kuulasmaa, T; Kuusisto, J; Laakso, M; Lakka, T; Uusitupa, M; Vangipurapu, J], 2021, Nature genetics, 53, 6, 840-860. A1 Journal article (refereed), original research
iNPH - the mystery resolving
Leinonen, Ville; Kuulasmaa, Teemu; Hiltunen, Mikko, 2021, Embo molecular medicine, 13, 3, e13720. B1 Non-refereed journal articles
A reference map of potential determinants for the human serum metabolome.
Bar, Noam; Korem, Tal; Weissbrod, Omer; Zeevi, David; Rothschild, Daphna; Leviatan, Sigal; Kosower, Noa; Lotan-Pompan, Maya; Weinberger, Adina; Le Roy, Caroline I; Menni, Cristina; Visconti, Alessia; Falchi, Mario; Spector, Tim D; Adamski, Jerzy; Franks, Paul W; Pedersen, Oluf; Segal, Eran; The IMI DIRECT Consortium [incl. Kuulasmaa, Teemu; Kokkola, Tarja; Laakso, Markku; Vangipurapu, Jagadish; Cederberg, Henna], 2020, Nature, 588, 135-140. A1 Journal article (refereed), original research
Clinical and Genetic Characterization of 153 Patients with Persistent or Transient Congenital Hyperinsulinism
Männistö, Jonna; Maria, Maleeha; Raivo, Joose; Kuulasmaa, Teemu; Otonkoski, Timo; Huopio, Hanna; Laakso, Markku, 2020, Journal of clinical endocrinology and metabolism, 105, 4, 1-9. A1 Journal article (refereed), original research
Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques
Natunen, Teemu; Martiskainen, Henna; Marttinen, Mikael; Gabbouj, Sami; Koivisto, Hennariikka; Kemppainen, Susanna; Kaipainen, Satu; Takalo, Mari; Svobodová, Helena; Leppänen, Luukas; Kemiläinen, Benjam; Ryhänen, Simo; Kuulasmaa, Teemu: Rahunen, Eija: Juutinen, Sisko; Mäkinen, Petra; Miettinen, Pasi; Rauramaa, Tuomas; Pihlajamäki, Jussi; Haapasalo, Annakaisa; et al [incl. Leinonen, Ville; Tanila, Heikki; Hiltunen, Mikko], 2020, Molecular neurodegeneration, 15, 66. A1 Journal article (refereed), original research
Microbiota-Related Metabolites and the Risk of Type 2 Diabetes
Vangipurapu, Jagadish; Fernandes Silva, Lilian; Kuulasmaa, Teemu; Smith, Ulf; Laakso, Markku, 2020, Diabetes care, 43, 6, 1319-1325. A1 Journal article (refereed), original research
Novel biomarkers associated with incident heart failure in 10 106 Finnish men
Jauhiainen, Raimo; Jauhiainen, Matti; Vangipurapu, Jagadish; Kuulasmaa, Teemu; Ala-Korpela, Mika; Laakso, Markku; Kuusisto, Johann, 2020, ESC heart failure, 2021; 8, 1, 605-614. A1 Journal article (refereed), original research
The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions
Takalo, Mari; Wittrahm, Rebekka; Wefers, Benedikt; Parhizkar, Samira; Jokivarsi, Kimmo; Kuulasmaa, Teemu; Mäkinen, Petra; Martiskainen, Henna; Wurst, Wolfgang; Xiang, Xianyuan; Marttinen, Mikael; Poutiainen, Pekka; Haapasalo, Annakaisa; Hiltunen, Mikko; Haass, Christian, 2020, Molecular neurodegeneration, 15, 1, 52. A1 Journal article (refereed), original research
An intronic variant in the GCKR gene is associated with multiple lipids
Fernandes, Silva L; Vangipurapu, J; Kuulasmaa, T; Laakso, M, 2019, Scientific reports, 9, 10240. A1 Journal article (refereed), original research
Disentangling the genetics of lean mass
Karasik, D; Zillikens, MC; Hsu, YH; Aghdassi, A; Akesson, K; Amin, N; Barroso, I; Bennett, DA; Bertram, L; Bochud, M; Borecki, IB; Broer, L; Buchman, AS; Byberg, L; Campbell, H; Campos-Obando, N; Cauley, JA; Cawthon, PM; Chambers, JC; Chen, Z; et al. (incl. Kuulasmaa, Teemu; Kuusisto, Johanna; Laakso, Markku), 2019, American journal of clinical nutrition, 109, 2, 276-287. A1 Journal article (refereed), original research
Genetic basis and outcome in a nationwide study of Finnish patients with hypertrophic cardiomyopathy
Jääskeläinen, P; Vangipurapu, J; Raivo, J; Kuulasmaa, T; Heliö, T; Aalto-Setälä, K; Kaartinen, M; Ilveskoski, E; Vanninen, S; Hämäläinen, L; Melin, J; Kokkonen, J; Nieminen, MS; FinHCM Study Group; Laakso, M; Kuusisto, J, 2019, ESC heart failure, 6, 3, 436-445. A1 Journal article (refereed), original research
Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration
Wilman, HR; Parisinos, CA; Atabaki-Pasdar, N; Kelly, M; Thomas, EL; Neubauer, S; Jennison, C; Ehrhardt, B; Baum, P; Schoelsch, C; Freijer, J; Grempler, R; Graefe-Mody, U; Hennige, A; Dings, C; Lehr, T; Scherer, N; Sihinecich, I; Pattou, F; Raverdi, V; et al. [Incl. Laakso, M; Kokkola, T; Kuulasmaa, T], 2019, Journal of hepatology, 71, 3, 594-602. A1 Journal article (refereed), original research
A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk
Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA, Mahajan A, Locke AE, Cingolani P, Pers TH, Viñuela A, Brown AA, Wu Y, Flannick J, Fuchsberger C, Gamazon ER, Gaulton KJ, Im HK et al. (incl. Lakka Timo, Kuulasmaa Teemu, Laakso Markku, Uusitupa Matti), 2017, Diabetes, 66, 7, 2019-2032. A1 Journal article (refereed), original research
Genetic risk scores in the prediction of plasma glucose, impaired insulin secretion, insulin resistance and incident type 2 diabetes in the METSIM study
Stancakova Alena, Kuulasmaa Teemu, Kuusisto Johanna, Mohlke Karen L, Collinis Francis S, Boehnke Michael, Laakso Markku, 2017, Diabetologia, 60, 9, 1722-1730. A1 Journal article (refereed), original research
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
Zillikens M Carola, Demissie Serkalem, Hsu Yi-Hsiang, Yerges-Armstrong Laura M, Chou Wen-Chi, Stolk Lisette, Livshits Gregory, Broer Linda, Johnson Toby, Koller Daniel L, Kutalik Zoltán, Luan Jian'an, Malkin Ida, Ried Janina S, Smith Albert V, Thorleifsson Gudmar, Vandenput Liesbeth, Zhao Jing Hua, Zhang Weihua, Aghdassi Ali et al. (incl. Cederberg Henna, Kuulasmaa Teemu, Kuusisto Johanna, Laakso Markku, Alena Stancáková), 2017, Nature communications, 8, 80. A1 Journal article (refereed), original research
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Jason F, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Tajes JF et al. (incl. Kuulasmaa Teemu, Kuusisto Johanna, Laakso Markku), 2017, Scientific data, 4, 170179. A1 Journal article (refereed), original research
The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases
Laakso Markku, Kuusisto Johanna, Stancakova Alena, Kuulasmaa Teemu, Pajukanta Päivi, Jake Lusis Aldons, Collins Francis S, Mohlke Karen, Boehnke Michael, 2017, Journal of lipid research, 58, 3, 481-493. A1 Journal article (refereed), original research
Clinical, Genetic, and Biochemical Characteristics of Early-Onset Diabetes in the Finnish Population
Huopio Hanna, Miettinen Päivi J, Ilonen Jorma, Nykänen Päivi, Veijola Riitta, Keskinen Päivi, Näntö-Salonen Kirsti, Vangipurapu Jagadish, Raivo Joose, Stancáková Alena, Männistö Jonna, Kuulasmaa Teemu, Knip Mikael, Otonkoski Timo, Laakso Markku, 2016, Journal of clinical endocrinology and metabolism, 101, 8, 3018-3026. A1 Journal article (refereed), original research
Detection of novel gene variants associated with congenital hypothyroidism in a Finnish patient cohort
Löf Christoffer, Patyra Konrad, Kuulasmaa Teemu, Vangipurapu Jagadish, Undeutsch Henriette, Jäschke Holger, Pajunen Tuulia, Kero Andreina, Krude Heiko, Biebermann Heike, Kleinau Gunnar, Kühnen Peter, Rantakari Krista, Miettinen Päivi, Kirjavainen Turkka, Pursiheimo Juha-Pekka, Mustila Taina, Jääskeläinen Jarmo, Ojaniemi Marja, Toppari Jorma et al, 2016, Thyroid, 26, 9, 1215-1224. A1 Journal article (refereed), original research
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Lu Yingchang, Day Felix R, Gustafsson Stefan, Buchkovich Martin L, Na Jianbo, Bataille Veronique, Cousminer Diana L, Dastani Zari, Drong Alexander W, Esko Tönu, Evans David M, Falchi Mario, Feitosa Mary F, Ferreira Teresa, Hedman Åsa K, Haring Robin, Hysi Pirro G, Iles Mark M, Justice Anne E, Kanoni Stavroula et al, 2016, Nature communications, 7, 10495. A1 Journal article (refereed), original research
The genetic architecture of type 2 diabetes
Fuchsberger Christian, Flannick Jason, Teslovich Tanya M, Mahajan Anubha, Agarwala Vineeta, Gaulton Kyle J, Ma Clement, Fontanillas Pierre, Moutsianas Loukas, McCarthy Davis J, Rivas Manuel A, Perry John RB, Sim Xueling, Blackwell Thomas W, Robertson Neil R, Rayner N William, Cingolani Pablo, Locke Adam E, Tajes Juan Fernandes, Highland Heather M, (incl Kuulasmaa Teemu), 2016, Nature, 536, 41-47. A1 Journal article (refereed), original research
Both fasting and glucose-stimulated proinsulin levels predict hyperglycemia and incident type 2 diabetes: a population-based study of 9,396 finnish men
Vangipurapu Jagadish, Stancáková Alena, Kuulasmaa Teemu, Kuusisto Johanna, Laakso Markku, 2015, PLoS ONE, 10, 4, e0124028. A1 Journal article (refereed), original research
Genetic risk clustering increases children's body weight at 2 years of age - the STEPS Study
Mäkelä J, Lagström H, Pitkänen N, Kuulasmaa T, Kaljonen A, Laakso M, Niinikoski H, 2015, Pediatric obesity, [epub ahead of print 11 Dec 2015]. A1 Journal article (refereed), original research
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus
Mahajan Anubha, Sim Xueling, Ng Hui Jin, Manning Alisa, Rivas Manuel A, Highland Heather M, Locke Adam E, Grarup Niels, Im Hae Kyung, Cingolani Pablo, Flannick Jason, Fontanillas Pierre, Fuchsberger Christian, Gaulton Kyle J, Teslovich Tanya M, Rayner N William, Robertson Neil R, Beer Nicola L, Rundle Jana K, Bork-Jensen Jette et al. On Behalf of the T2D-GENES consortium and GoT2D consortium, 2015, PLoS genetics, 11, 1, e1004876. A1 Journal article (refereed), original research
Long-term changes in glucose metabolism after gestational diabetes: a double cohort study
Huopio Hanna, Hakkarainen Heidi, Pääkkönen Mirja, Kuulasmaa Teemu, Voutilainen Raimo, Heinonen Seppo, Cederberg Henna, 2014, Bmc pregnancy and childbirth, 14, 296. A1 Journal article (refereed), original research
Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes
Huopio H, Cederberg H, Vangipurapu J, Hakkarainen H, Pääkkönen M, Kuulasmaa T, Heinonen S, Laakso M, 2013, European journal of endocrinology, 169, 3, 291-297. A1 Journal article (refereed), original research
Association between liver insulin resistance and cardiovascular risk factors
Vangipurapu Jagadish, Stančáková A, Kuulasmaa Teemu, Soininen Pasi, Kangas AJ, Ala-Korpela Mika, Kuusisto Johanna, Laakso Markku, 2012, Journal of internal medicine, 272, 402-408. A1 Journal article (refereed), original research
Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men
Vangipurapu J, Stancakova A, Pihlajamäki J, Kuulasmaa TM, Kuulasmaa T, Paananen J, Kuusisto J, Ferrannini E, Laakso M, 2011, Diabetologia, 54, 563-571. A1 Journal article (refereed), original research
Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis
Pirinen E, Gylling H, Itkonen P, Yaluri N, Heikkinen S, Pietilä M, Kuulasmaa T, Tusa M, Cerrada-Gimenez M, Pihlajamäki J, Alhonen L, Jänne J, Miettinen TA & Laakso M, 2010, Amino acids, 38, 549-560. A1 Journal article (refereed), original research
Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men
Stancáková A, Kuulasmaa T, Paananen J, Jackson AU, Bonnycastle LL, Collins FS, Boehnke M, Kuusisto J, Laakso M, 2009, Diabetes, 58, 2129-2136. A1 Journal article (refereed), original research
Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men
Stancáková A, Javorský M, Kuulasmaa T, Haffner SM, Kuusisto J, Laakso M, 2009, Diabetes, 58, 1212-1221. A1 Journal article (refereed), original research
Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics
Koutnikova H, Laakso M, Lu L, Combe R, Paananen J, Kuulasmaa T, Kuusisto J, Häring H-U, Hansen T, Pedersen O, Smith U, Hanefeld M, Williams RW, Auwerx J, 2009, PLoS genetics, 5, e100591. A1 Journal article (refereed), original research
Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study
Laakso M, Zilinskaite J, Hansen T, Boesgaard TW, Vänttinen M, Stancáková A, Jansson P-A, Pellmé F, Holst JJ, Kuulasmaa T, Hribal ML, Sesti G, Stefan N, Fritsche A, Häring H, Pedersen O, Smith U, for the EUGENE2 Consortium, 2008, Diabetologia, 51, 502-511. A1 Journal article (refereed), original research
Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism
Pirinen E, Kuulasmaa T, Pietilä M, Heikkinen S, Tusa M, Itkonen P, Boman S, Skommer J, Virkamäki A, Hohtola E, Kettunen M, Fatrai S, Kansanen E, Koota S, Niiranen K, Parkkinen J, Levonen A-L, Ylä-Herttuala S, Hiltunen JK, Alhonen L, Smith U, Jänne J, 2007, Molecular and cellular biology, 27, 13, 4953-4967. A1 Journal article (refereed), original research
Genetic variation within the APPL locus is not associated with metabolic or inflammatory traits in a healthy white population
Staiger H, Machicao F, Machann J, Schick F, Kuulasmaa T, Laakso M, Fritsche A, Stefan N, Häring H-U, Laakso M, 2007, Diabetic medicine, 24, 817-822. A1 Journal article (refereed), original research
Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans
Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Kuusisto J, Laakso M, 2007, Obesity, 15, 2902-2907. A1 Journal article (refereed), original research
Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects
Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Laakso M, Laakso M, 2007, Journal of clinical endocrinology and metabolism, 92, 1112-1117. A1 Journal article (refereed), original research
Single nucleotide polymorphisms of the peroxisome proliferator-activated receptor-alpha gene (PPARA) influence the conversion from impaired glucose tolerance to type 2 diabetes. The STOP-NIDDM Trial
Andrulionyté L, Kuulasmaa T, Chiasson J-L, Laakso M, for the STOPP-NIDDM Study Group, Laakso M, 2007, Diabetes, 56, 1181-1186. A1 Journal article (refereed), original research
Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion
Wang J, Kuusisto J, Vänttinen M, Kuulasmaa T, Lindström J, Tuomilehto J, Uusitupa M, Laakso M, Laakso M, 2007, Diabetologia, 50, 1192-1200. A1 Journal article (refereed), original research
Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offpring of patients with type 2 diabetes
Pihlajamäki J, Kinnunen M, Ruotsalainen E, Salmenniemi U, Vauhkonen I, Kuulasmaa T, Kainulainen S, Laakso M, Laakso M, 2005, Diabetologia, 48, 1331-1334. A1 Journal article (refereed), original research
Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake
Vänttinen M, Nuutila P, Kuulasmaa T, Pihlajamäki J, Hällsten K, Virtanen KA, Lautamäki R, Peltoniemi P, Takala T, Viljanen APM, Knuuti J, Laakso M, Laakso M, 2005, Diabetes, 54, 3587-3591. A1 Journal article (refereed), original research

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Teemu Kuulasmaa

Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models

Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers

New insights into the genetic etiology of Alzheimer’s disease and related dementias

A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

Isoflurane affects brain functional connectivity in rats 1 month after exposure

MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation

Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT: An IMI DIRECT study

The association of nine amino acids with cardiovascular events in Finnish men in a 12-year follow-up study

The trans-ancestral genomic architecture of glycemic traits

iNPH - the mystery resolving

A reference map of potential determinants for the human serum metabolome.

Clinical and Genetic Characterization of 153 Patients with Persistent or Transient Congenital Hyperinsulinism

Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques

Microbiota-Related Metabolites and the Risk of Type 2 Diabetes

Novel biomarkers associated with incident heart failure in 10 106 Finnish men

The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions

An intronic variant in the GCKR gene is associated with multiple lipids

Disentangling the genetics of lean mass

Genetic basis and outcome in a nationwide study of Finnish patients with hypertrophic cardiomyopathy

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

Genetic risk scores in the prediction of plasma glucose, impaired insulin secretion, insulin resistance and incident type 2 diabetes in the METSIM study

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases

Clinical, Genetic, and Biochemical Characteristics of Early-Onset Diabetes in the Finnish Population

Detection of novel gene variants associated with congenital hypothyroidism in a Finnish patient cohort

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

The genetic architecture of type 2 diabetes

Both fasting and glucose-stimulated proinsulin levels predict hyperglycemia and incident type 2 diabetes: a population-based study of 9,396 finnish men

Genetic risk clustering increases children's body weight at 2 years of age - the STEPS Study

Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus

Long-term changes in glucose metabolism after gestational diabetes: a double cohort study

Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes

Association between liver insulin resistance and cardiovascular risk factors

Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men

Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis

Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men

Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men

Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics

Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study

Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism

Genetic variation within the APPL locus is not associated with metabolic or inflammatory traits in a healthy white population

Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans

Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects

Single nucleotide polymorphisms of the peroxisome proliferator-activated receptor-alpha gene (PPARA) influence the conversion from impaired glucose tolerance to type 2 diabetes. The STOP-NIDDM Trial

Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion

Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offpring of patients with type 2 diabetes

Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake