Tuomo Keinänen
Visiting Researcher
PhD, Adjunct professor chemical biology, project reseacher
Department of Technical Physics, Faculty of Science, Forestry and Technology
[email protected] | +358 40 355 2387
I apply a chemical-biological approach to the implementation of business and basic research projects supported by various funders.
I also have long-term basic research experience in the study of biogenic amines (cell growth and differentiation at the molecular / macromolecular level) and in the application of basic research to the development / prevention of diabetes-related organ damage and the early diagnosis of cancer using various molecular markers. The re-allocation of drugs to new therapeutic areas and the study of their new targets have been part of my research history. I also have project-based know-how from recycled rubber, microplastic and biofilters. Recently, I have used a Gilson PLC-2250 with a CPC1000 unit to isolate phenolic fractions from the slow pyrolysis fluids.
Research groups
Publications
81/81 items-
Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions
Hyvönen, Mervi T.; Smirnova, Olga A.; Mitkevich, Vladimir A.; Tunitskaya, Vera L.; Khomutov, Maxim; Karpov, Dmitry S.; Korolev, Sergey P.; Häkkinen, Merja R.; Pietilä, Marko; Gottikh, Marina B.; Vepsäläinen, Jouko; Alhonen, Leena; Makarov, Alexander A.; Kochetkov, Sergey N.; Wallace, Heather M.; Keinänen, Tuomo A.; Khomutov, Alex R., 2022, International journal of molecular sciences, 23, 9, 4614. A1 Journal article (refereed), original research -
α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation
Hyvönen, Mervi T; Khomutov, Maxim; Vepsäläinen, Jouko; Khomutov, Alex R; Keinänen, Tuomo A, 2021, Biomolecules, 11, 5, 707. A1 Journal article (refereed), original research -
Novel fleximer pyrazole-containing adenosine analogues: chemical, enzymatic and highly efficient biotechnological synthesis
Khandazhinskaya, Anastasia; Eletskaya, Barbara; Fateev, Ilja; Kharitonova, Maria; Konstantinova, Irina; Barai, Vladimir; Azhayev, Alex; Hyvonen, Mervi T.; Keinanen, Tuomo A.; Kochetkov, Sergey; Seley-Radtke, Katherine; Khomutov, Alex; Matyugina, Elena, 2021, Organic and biomolecular chemistry, 19, 34, 7379-7389. A1 Journal article (refereed), original research -
Chemical activation of SAT1 corrects diet-induced metabolic syndrome
Castoldi, Francesca; Hyvönen, Mervi T; Durand, Sylvère; Aprahamian, Fanny; Sauvat, Allan; Malik, Shoaib A; Baracco, Elisa Elena; Vacchelli, Erika; Opolon, Paule; Signolle, Nicolas; Lefevre, Déborah; Bossut, Noelie; Eisenberg, Tobias; Dammbrueck, Christopher; Pendl, Tobias; Kremer, Margerie; Lachkar, Sylvie; Einer, Claudia; Michalke, Bernhard; Zischka, Hans et al. [incl. Keinänen, Tuomo], 2020, Cell death and differentiation, 27, 10, 2904-2920. A1 Journal article (refereed), original research -
Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase
Hyvönen, Mervi; Keinänen, Tuomo; Nuraeva, Gulgina; Yanvarev, Dmitry; Khomutov, Maxim; Khurs, Elena; Kochetkov, Sergey; Vepsäläinen, Jouko; Zhgun, Alexander; Khomutov, Alex, 2020, Biomolecules, 10, 3, 406. A1 Journal article (refereed), original research -
Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine
Khomutov, MA; Hyvönen, MT; Salikhov, AI; Chizhov, AO; Ryzhov, IM; Kochetkov, SN; Vepsäläinen, J; Keinänen, TA; Khomutov, AR, 2020, Russian journal of bioorganic chemistry, 46, 6, 686-692. A1 Journal article (refereed), original research -
Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives
Khomutov, Maxim; Hyvönen, Mervi T; Simonian, Alina; Formanovsky, Andrey A; Mikhura, Irina V; Chizhov, Alexander O; Kochetkov, Sergey N; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Khomutov, Alex R, 2019, Journal of medicinal chemistry, 62, 24, 11335-11347. A1 Journal article (refereed), original research -
Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N1-acetylpolyamine oxidase
Khomutov, Maxim A; Hyvönen, Mervi T; Simonian, Alina R; Weisell, Janne; Vepsäläinen, Jouko; Alhonen, Leena; Kochetkov, Sergey N; Keinänen, Tuomo A; Khomutov, Alex R, 2018, Mendeleev communications, 28, 5, 479-481. A1 Journal article (refereed), original research -
Activation of Polyamine Catabolism by N¹,N11-Diethylnorspermine in Hepatic HepaRG Cells Induces Dedifferentiation and Mesenchymal-Like Phenotype
Ivanova, ON; Snezhkina, AV; Krasnov, GS; Valuev-Elliston, VT; Khomich, OA; Khomutov, AR; Keinanen, TA; Alhonen, L; Bartosch, B; Kudryavtseva, AV; Kochetkov, SN; Ivanov, AV, 2018, Cells, 7, 12, 275. A1 Journal article (refereed), original research -
Controlling of N-Alkylpolyamine Analogue Metabolism by Selective Deuteration
Ucal, Sebahat; Häkkinen, Merja R; Alanne, Aino-Liisa; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Hyvönen, Mervi T, 2018, Biochemical journal, 475, 3, 663-676. A1 Journal article (refereed), original research