Ville Koistinen

Analysis of Methylated Quaternary Ammonium Compounds Using Hydrophilic Interaction Liquid Chromatography Combined With Mass Spectrometry

Zarei, Iman; Babu, Ambrin Farizah; Koistinen, Ville M; Tuomainen, Marjo; Kårlund, Anna; Haikonen, Retu; Lehtonen, Marko; Hanhineva, Kati. 2025. Mass spectrometry reviews. [First published: 29 May 2025]: 1-13 A2 Review article, Literature review, Systematic review

Blueprint of the distinct metabolite profiles of healthy pig heart chambers

Haikonen, Retu; Meuronen, Topi; Koistinen, Ville; Kärkkäinen, Olli; Tuomainen, Tomi; Solano-Aguilar, Gloria I; Urban, Joseph F; Lehtonen, Marko; Tavi, Pasi; Hanhineva, Kati. 2025. Journal of molecular and cellular cardiology plus. 13: . 100462 A1 Journal article (refereed), original research

Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention

Amadieu, Camille; Ahmed, Hany; Leclercq, Sophie; Koistinen, Ville; Leyrolle, Quentin; Stärkel, Peter; Bindels, Laure B; Layé, Sophie; Neyrinck, Audrey M; Kärkkäinen, Olli; De Timary, Philippe; Hanhineva, Kati; Delzenne, Nathalie M. 2025. Clinical nutrition ESPEN. 66: 361-371 A1 Journal article (refereed), original research

Effect of the Roast Level on Lipophilic and Hydrophilic Compounds in Pot and Filter Coffee Beverages

Ollennu-Chuasam, Priscilla; Suomela, Jukka-Pekka; Hanhineva, Kati; Linderborg, Kaisa M.; Koistinen, Ville. 2025. ACS food science & technology. 5: 2187-2202 A1 Journal article (refereed), original research

Existing food processing classifications overlook the phytochemical composition of processed plant-based protein-rich foods

Raita, Jasmin; Ahmed, Hany; Chen, Kang; Houttu, Veera; Haikonen, Retu; Kårlund, Anna; Kortesniemi, Maaria; Yang, Baoru; Koistinen, Ville; Hanhineva, Kati. 2025. Nature food. 6: 503-512 A1 Journal article (refereed), original research

Metabolite variations in faba bean ingredients: Unraveling the links between off-flavors and chemical compounds

Tuccillo, Fabio; Kårlund, Anna; Koistinen, Ville; Saini, Shania; Ahmed, Hany; Hanhineva, Kati; Sandell, Mari; Katina, Kati; Lampi, Anna-Maija. 2025. Food chemistry. 479: A1 Journal article (refereed), original research

Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder

Leclercq, Sophie; Ahmed, Hany; Amadieu, Camille; Petit, Géraldine; Koistinen, Ville; Leyrolle, Quentin; Poncin, Marie; Stärkel, Peter; Kok, Eloise; Karhunen, Pekka J; de Timary, Philippe; Laye, Sophie; Neyrinck, Audrey M; Kärkkäinen, Olli K; Hanhineva, Kati; Delzenne, Nathalie. 2024. eLife. 13: . RP96937 A1 Journal article (refereed), original research

Eight-year Diet and Physical Activity Intervention Affects Serum Metabolites during Childhood & Adolescence: A Nonrandomized Controlled Trial

Zarei, Iman; Eloranta, Aino-Maija; Klåvus, Anton; Väistö, Juuso; Lehtonen, Marko; Mikkonen, Santtu; Koistinen, Ville M; Sallinen, Taisa; Haapala, Eero A; Lintu, Niina; Soininen, Sonja; Haikonen, Retu; Atalay, Mustafa; Schwab, Ursula; Auriola, Seppo; Kolehmainen, Marjukka; Hanhineva, Kati; Lakka, Timo A. 2024. iScience. 27: A1 Journal article (refereed), original research

Lipophilic and Hydrophilic Metabolites as Descriptors of Different Coffee Beverages

Ollennu-Chuasam, Priscilla; Ahmed, Hany; Koistinen, Ville; Hanhineva, Kati; Linderborg, Kaisa M; Suomela, Jukka-Pekka. 2024. Journal of agricultural and food chemistry. 72: 16461-16474 A1 Journal article (refereed), original research

Metabolic changes in response to varying whole-grain wheat and rye intake

Koistinen, Ville M; Haldar, Sumanto; Tuomainen, Marjo; Lehtonen, Marko; Klåvus, Anton; Draper, John; Lloyd, Amanda; Beckmann, Manfred; Bal, Wendy; Ross, Alastair B; Brandt, Kirsten; Fawcett, Lee; Seal, Chris; Hanhineva, Kati. 2024. npj science of food. 8: . 8 A1 Journal article (refereed), original research

Associations of altered hepatic gene expression in American lifestyle-induced obesity syndrome diet-fed mice with metabolic changes during NAFLD development and progression

Iannone, V; Lok, J; Babu, AF; Gómez-Gallego, C; Willman, RM; Koistinen, VM; Klåvus, A; Kettunen, MI; Kårlund, A; Schwab, U; Hanhineva, K; Kolehmainen, M; Nezami, H El. 2023. Journal of nutritional biochemistry. 115: A1 Journal article (refereed), original research

Impacts of maternal microbiota and microbial metabolites on fetal intestine, brain, and placenta

Husso, Aleksi; Pessa-Morikawa, Tiina; Koistinen, Ville Mikael; Kärkkäinen, Olli; Kwon, Hyuk Nam; Lahti, Leo; Iivanainen, Antti; Hanhineva, Kati; Niku, Mikael. 2023. Bmc biology. 21: . 207 A1 Journal article (refereed), original research

Nutritional metabolomics: Recent developments and future needs

Kortesniemi, Maaria; Noerman, Stefania; Kårlund, Anna; Raita, Jasmin; Meuronen, Topi; Koistinen, Ville; Landberg, Rikard; Hanhineva, Kati. 2023. Current opinion in chemical biology. 77: A2 Review article, Literature review, Systematic review

Towards a Rosetta stone for metabolomics: recommendations to overcome inconsistent metabolite nomenclature

Koistinen, Ville; Kärkkäinen, Olli; Keski-Rahkonen, Pekka; Tsugawa, Hiroshi; Scalbert, Augustin; Arita, Masanori; Wishart, David; Hanhineva, Kati. 2023. Nature metabolism. 5: 351-354 B1 Non-refereed journal articles

Diet- and microbiota-related metabolite, 5-aminovaleric acid betaine (5-AVAB), in health and disease

Haikonen, Retu; Kärkkäinen, Olli; Koistinen, Ville; Hanhineva, Kati. 2022. Trends in endocrinology and metabolism. 33: 463-480 A2 Review article, Literature review, Systematic review

Effects of exercise on NAFLD using non-targeted metabolomics in adipose tissue, plasma, urine, and stool

Babu, Ambrin Farizah; Csader, Susanne; Männistö, Ville; Tauriainen, Milla-Maria; Pentikäinen, Heikki; Savonen, Kai; Klåvus, Anton; Koistinen, Ville; Hanhineva, Kati; Schwab, Ursula. 2022. Scientific reports. 12: A1 Journal article (refereed), original research

Identification and Distribution of Sterols, Bile Acids, and Acylcarnitines by LC–MS/MS in Humans, Mice, and Pigs—A Qualitative Analysis

Babu, Ambrin Farizah; Koistinen, Ville Mikael; Turunen, Soile; Solano-Aguilar, Gloria; Urban, Joseph F.; Zarei, Iman; Hanhineva, Kati. 2022. Metabolites. 12: A1 Journal article (refereed), original research

Maternal microbiota-derived metabolic profile in fetal murine intestine, brain and placenta

Pessa-Morikawa, Tiina; Husso, Aleksi; Kärkkäinen, Olli; Koistinen, Ville; Hanhineva, Kati; Iivanainen, Antti; Niku, Mikael. 2022. Bmc microbiology. 22: . 46 A1 Journal article (refereed), original research

Metabolite Pattern Derived from Lactiplantibacillus plantarum — Fermented Rye Foods and In Vitro Gut Fermentation Synergistically Inhibits Bacterial Growth

Koistinen, Ville M.; Hedberg, Maria; Shi, Lin; Johansson, Anders; Savolainen, Otto; Lehtonen, Marko; Aura, Anna‐Marja; Hanhineva, Kati; Landberg, Rikard. 2022. Molecular nutrition and food research. 66: A1 Journal article (refereed), original research

Microbiota-derived metabolites as drivers of gut–brain communication

Ahmed, Hany; Leyrolle, Quentin; Koistinen, Ville; Kärkkäinen, Olli; Layé, Sophie; Delzenne, Nathalie; Hanhineva, Kati. 2022. Gut microbes. 14: A2 Review article, Literature review, Systematic review

Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition

Zarei, Iman; Koistinen, Ville M.; Kokla, Marietta; Klåvus, Anton; Babu, Ambrin Farizah; Lehtonen, Marko; Auriola, Seppo; Hanhineva, Kati. 2022. Scientific reports. 12: . 15018 A1 Journal article (refereed), original research

Associations of the serum metabolite profile with a healthy Nordic diet and risk of coronary artery disease

Noerman, Stefania; Kokla, Marietta; Koistinen, Ville M; Lehtonen, Marko; Tuomainen, Tomi-Pekka; Brunius, Carl; Virtanen, Jyrki K; Hanhineva, Kati. 2021. Clinical nutrition. 40: 3250-3262 A1 Journal article (refereed), original research

Data sharing in PredRet for accurate prediction of retention time: Application to plant food bioactive compounds

Low, Dorrain Yanwen; Micheau, Pierre; Koistinen, Ville Mikael; Hanhineva, Kati; Abrankó, László; Rodriguez-Mateos, Ana; da Silva, Andreia Bento; van Poucke, Christof; Almeida, Conceição; Andres-Lacueva, Cristina; Rai, Dilip K.; Capanoglu, Esra; Tomás Barberán, Francisco A.; Mattivi, Fulvio; Schmidt, Gesine; Gürdeniz, Gözde; Valentová, Katerina; Bresciani, Letizia; Petrásková, Lucie; Dragsted, Lars Ove et al.. 2021. Food chemistry. 357: 129757 A1 Journal article (refereed), original research

Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective

Zhang, Pei; Carlsten, Christopher; Chaleckis, Romanas; Hanhineva, Kati; Huang, Mengna; Isobe, Tomohiko; Koistinen, Ville M.; Meister, Isabel; Papazian, Stefano; Sdougkou, Kalliroi; Xie, Hongyu; Martin, Jonathan W.; Rappaport, Stephen M.; Tsugawa, Hiroshi; Walker, Douglas I.; Woodruff, Tracey J.; Wright, Robert O.; Wheelock, Craig E.. 2021. Environmental science & technology letters. 8: 839-852 A2 Review article, Literature review, Systematic review

Putative metabolites involved in the beneficial effects of wholegrain cereal: Nontargeted metabolite profiling approach

Vitale, Marilena; Hanhineva, Kati; Koistinen, Ville; Auriola, Seppo; Paananen, Jussi; Costabile, Giuseppina; Della Pepa, Giuseppe; Rivellese, Angela A.; Riccardi, Gabriele; Giacco, Rosalba. 2021. Nutrition metabolism and cardiovascular diseases. 31: 1156-1165 A1 Journal article (refereed), original research

Terpenoid and lipid profiles vary in different Phytophthora cactorum - strawberry interactions

Toljamo, Anna; Koistinen, Ville; Hanhineva, Kati; Kärenlampi, Sirpa; Kokko, Harri. 2021. Phytochemistry. 189: 112820 A1 Journal article (refereed), original research

"notame": Workflow for Non-Targeted LC-MS Metabolic Profiling

Klåvus, Anton; Kokla, Marietta; Noerman, Stefania; Koistinen, Ville M; Tuomainen, Marjo; Zarei, Iman; Meuronen, Topi; Häkkinen, Merja R; Rummukainen, Soile; Farizah Babu, Ambrin; Sallinen, Taisa; Kärkkäinen, Olli; Paananen, Jussi; Broadhurst, David; Brunius, Carl; Hanhineva, Kati. 2020. Metabolites. 10: 135 A1 Journal article (refereed), original research

Side-stream products of malting: a neglected source of phytochemicals

Koistinen, Ville M; Tuomainen, Marjo; Lehtinen, Pekka; Peltola, Petri; Auriola, Seppo; Jonsson, Karin; Hanhineva, Kati. 2020. npj science of food. 4: 21 A1 Journal article (refereed), original research

Contribution of gut microbiota to metabolism of dietary glycine betaine in mice and in vitro colonic fermentation

Koistinen, VM; Kärkkäinen, O; Borewicz, K; Zarei, I; Jokkala, J; Micard, V; Rosa-Sibakov, N; Auriola, S; Aura, AM; Smidt, H; Hanhineva, K. 2019. Microbiome. 7: 103 A1 Journal article (refereed), original research

Effects of food processing and gut microbial metabolism on whole grain phytochemicals : a metabolomics approach

Koistinen, Ville Mikael. 2019. Publications of the University of Eastern Finland. Dissertations in Health Sciences G5 Doctoral dissertation (article)

Factors affecting intake, metabolism and health benefits of phenolic acids: do we understand individual variability?

Bento-Silva, A; Koistinen, VM; Mena, P; Bronze, MR; Hanhineva, K; Sahlstrøm, S; Kitryte, V; Moco, S; Aura, AM. 2019. European journal of nutrition. [First Online 21 May 2019]: 1-19 A2 Review article, Literature review, Systematic review

Diets rich in whole grains increase betainized compounds associated with glucose metabolism

Kärkkäinen, O; Lankinen, MA; Vitale, M; Jokkala, J; Leppänen, J; Koistinen, V; Lehtonen, M; Giacco, R; Rosa-Sibakov, N; Micard, V; Rivellese, AAA; Schwab, U; Mykkänen, H; Uusitupa, M; Kolehmainen, M; Riccardi, G; Poutanen, K; Auriola, S; Hanhineva, K. 2018. American journal of clinical nutrition. 108: 971-979 A1 Journal article (refereed), original research

Interlaboratory Coverage Test on Plant Food Bioactive Compounds and their Metabolites by Mass Spectrometry-Based Untargeted Metabolomics

Koistinen, VM; da Silva, AB; Abrankó, L; Low, D; Villalba, RG; Barberán, FT; Landberg, R; Savolainen, O; Alvarez-Acero, I; de Pascual-Teresa, S; Van Poucke, C; Almeida, C; Petrásková, L; Valentová, K; Durand, S; Wiczkowski, W; Szawara-Nowak, D; González-Domínguez, R; Llorach, R; Andrés-Lacueva, C; et al.. 2018. Metabolites. 8: 46 A1 Journal article (refereed), original research

Mastication-induced release of compounds from rye and wheat breads to saliva

Pentikäinen, Saara; Koistinen, Ville; Kolehmainen, Marjukka; Poutanen, Kaisa; Hanhineva, Kati; Aura, Anna-Marja. 2018. Food chemistry. 2019; 270: 502-508 A1 Journal article (refereed), original research

Metabolic profiling of sourdough fermented wheat and rye bread

Koistinen, VM; Mattila, O; Katina, K; Poutanen, K; Aura, AM; Hanhineva, K. 2018. Scientific reports. 8: 5684 A1 Journal article (refereed), original research

Whole grain intake associated molecule 5-aminovaleric acid betaine decreases ß-oxidation of fatty acids in mouse cardiomyocytes

Kärkkäinen, Olli; Tuomainen, Tomi; Koistinen, Ville; Tuomainen, Marjo; Leppänen, Jukka; Laitinen, Tuomo; Lehtonen, Marko; Rysä, Jaana; Auriola, Seppo; Poso, Antti; Tavi, Pasi; Hanhineva, Kati. 2018. Scientific reports. 8: 13036 A1 Journal article (refereed), original research

Effect of Bioprocessing on the In Vitro Colonic Microbial Metabolism of Phenolic Acids from Rye Bran Fortified Breads

Koistinen VM, Nordlund E, Katina K, Mattila I, Poutanen K, Hanhineva K, Aura A-M. 2017. Journal of agricultural and food chemistry. 65: 1854-1864 A1 Journal article (refereed), original research

Mass spectrometry-based analysis of whole-grain phytochemicals

Koistinen Ville Mikael, Hanhineva Kati. 2017. Critical reviews in food science and nutrition. 57: 1688-1709 A2 Review article, Literature review, Systematic review

Microbial and endogenous metabolic conversions of rye phytochemicals

Koistinen Ville M, Hanhineva Kati. 2017. Molecular nutrition and food research. 61: 1600627 A2 Review article, Literature review, Systematic review

Changes in the phytochemical profile of rye bran induced by enzymatic bioprocessing and sourdough fermentation

Koistinen Ville Mikael, Katina Kati, Nordlund Emilia, Poutanen Kaisa, Hanhineva Kati. 2016. Food research international. 89: 1106-1115 A1 Journal article (refereed), original research

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Keywords

Analysis of Methylated Quaternary Ammonium Compounds Using Hydrophilic Interaction Liquid Chromatography Combined With Mass Spectrometry

Blueprint of the distinct metabolite profiles of healthy pig heart chambers

Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention

Effect of the Roast Level on Lipophilic and Hydrophilic Compounds in Pot and Filter Coffee Beverages

Existing food processing classifications overlook the phytochemical composition of processed plant-based protein-rich foods

Metabolite variations in faba bean ingredients: Unraveling the links between off-flavors and chemical compounds

Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder

Eight-year Diet and Physical Activity Intervention Affects Serum Metabolites during Childhood & Adolescence: A Nonrandomized Controlled Trial

Lipophilic and Hydrophilic Metabolites as Descriptors of Different Coffee Beverages

Metabolic changes in response to varying whole-grain wheat and rye intake

Associations of altered hepatic gene expression in American lifestyle-induced obesity syndrome diet-fed mice with metabolic changes during NAFLD development and progression

Impacts of maternal microbiota and microbial metabolites on fetal intestine, brain, and placenta

Nutritional metabolomics: Recent developments and future needs

Towards a Rosetta stone for metabolomics: recommendations to overcome inconsistent metabolite nomenclature

Diet- and microbiota-related metabolite, 5-aminovaleric acid betaine (5-AVAB), in health and disease

Effects of exercise on NAFLD using non-targeted metabolomics in adipose tissue, plasma, urine, and stool

Identification and Distribution of Sterols, Bile Acids, and Acylcarnitines by LC–MS/MS in Humans, Mice, and Pigs—A Qualitative Analysis

Maternal microbiota-derived metabolic profile in fetal murine intestine, brain and placenta

Metabolite Pattern Derived from Lactiplantibacillus plantarum — Fermented Rye Foods and In Vitro Gut Fermentation Synergistically Inhibits Bacterial Growth

Microbiota-derived metabolites as drivers of gut–brain communication

Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition

Associations of the serum metabolite profile with a healthy Nordic diet and risk of coronary artery disease

Data sharing in PredRet for accurate prediction of retention time: Application to plant food bioactive compounds

Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective

Putative metabolites involved in the beneficial effects of wholegrain cereal: Nontargeted metabolite profiling approach

Terpenoid and lipid profiles vary in different Phytophthora cactorum - strawberry interactions

"notame": Workflow for Non-Targeted LC-MS Metabolic Profiling

Side-stream products of malting: a neglected source of phytochemicals

Contribution of gut microbiota to metabolism of dietary glycine betaine in mice and in vitro colonic fermentation

Effects of food processing and gut microbial metabolism on whole grain phytochemicals : a metabolomics approach

Factors affecting intake, metabolism and health benefits of phenolic acids: do we understand individual variability?

Diets rich in whole grains increase betainized compounds associated with glucose metabolism

Interlaboratory Coverage Test on Plant Food Bioactive Compounds and their Metabolites by Mass Spectrometry-Based Untargeted Metabolomics

Mastication-induced release of compounds from rye and wheat breads to saliva

Metabolic profiling of sourdough fermented wheat and rye bread

Whole grain intake associated molecule 5-aminovaleric acid betaine decreases ß-oxidation of fatty acids in mouse cardiomyocytes

Effect of Bioprocessing on the In Vitro Colonic Microbial Metabolism of Phenolic Acids from Rye Bran Fortified Breads

Mass spectrometry-based analysis of whole-grain phytochemicals

Microbial and endogenous metabolic conversions of rye phytochemicals

Changes in the phytochemical profile of rye bran induced by enzymatic bioprocessing and sourdough fermentation