Virve Kärkkäinen - UEFConnect

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Altered tear fluid protein expression in persons with mild Alzheimer's disease in proteins involved in oxidative stress, protein synthesis, and energy metabolism
Kärkkäinen, Virve; Saari, Toni; Hannonen, Sanna; Rusanen, Minna; Lehtola, Juha-Matti; Uusitalo, Hannu; Leinonen, Ville; Thiede, Bernd; Kaarniranta, Kai; Koivisto, Anne M; Utheim, Tor P, 2025, Journal of Alzheimer's disease, 105, 1, 292-301. A1 Journal article (refereed), original research
Neuroinflammation Markers in Tear Fluid of Mild Alzheimer’s Disease
Kärkkäinen, Virve; Saari, Toni; Rusanen, Minna; Uusitalo, Hannu; Leinonen, Ville; Thiede, Bernd; Kaarniranta, Kai; Koivisto, Anne M.; Utheim, Tor P., 2025, Journal of molecular neuroscience, 75, 2, 73. A1 Journal article (refereed), original research
Pupil Size Derived Features Improve the Accuracy of Eye-Tracker Based MCI Classification
Andberg, Sami; Shah, Hasnain Ali; Hannonen, Sanna; Kärkkäinen, Virve; Kaarniranta, Kai; Koivisto, Anne M; Bednarik, Roman, 2025, González, Alejandro Rodríguez; Sicilia, Rosa; Santamaría, Lucía Prieto; Papadopoulos, George A; Guarrasi, Valerio; Cazzolato, Mirela Teixeira; Kane, Bridget, 2025 IEEE 38th International Symposium on Computer-Based Medical Systems (CBMS), 957-962. A4 Conference proceedings
The Annual Incidence of Vascular Dementia and Other Dementias: A Population-Based Study in Eastern Finland
Tuominen, Ada; Kärkkäinen, Virve; Jetsonen, Viivi; Selander, Tuomas; Lappalainen, Olli; Jäkälä, Pekka; Koivisto, Anne, 2025, Neuroepidemiology, [Epub ahead of print 12 Mar 2025], 1-7. A1 Journal article (refereed), original research
Gut Microbiome Changes in Patients With Idiopathic Normal Pressure Hydrocephalus
Brandt, Emilia; Koivisto, Anne; Pereira, Pedro; Mustanoja, Ella; Auvinen, Petri; Saari, Toni; Lehtola, Juha-Matti; Hannonen, Sanna; Rusanen, Minna; Leinonen, Ville; Scheperjans, Filip; Kärkkäinen, Virve, 2024, Alzheimer disease and associated disorders, 38, 2, 133-139. A1 Journal article (refereed), original research
Tear fluid reflects the altered protein expressions of Alzheimer's disease patients in proteins involved in protein repair and clearance system or the regulation of cytoskeleton
Kärkkäinen, V; Hannonen, S; Rusanen M; Lehtola, JM; Saari, T; Uusitalo, H; Leinonen, V; Thiede, B; Kaarniranta, K; Koivisto, AM; Utheim, T, 2024, Journal of Alzheimer's disease, [First published online November 18, 2024], 1-8. A1 Journal article (refereed), original research
Prevalence of pre-eclampsia in 265 patients with an intracranial aneurysm, 393 female relatives versus a control cohort: A case–control study
Kotikoski, Satu; Paavola, Juho; Nurmonen, Heidi J; Kärkkäinen, Virve; Huuskonen, Terhi J; Huttunen, Jukka; Koivisto, Timo; von und zu Fraunberg, Mikael; Jääskeläinen, Juha E; Lindgren, Antti E, 2023, European journal of neurology, 2024; 31, 2, e16113. A1 Journal article (refereed), original research
Computer-based Eye-tracking Analysis of King-Devick Test Differentiates Persons With Idiopathic Normal Pressure Hydrocephalus From Cognitively Unimpaired
Lehtola, Juha-Matti; Kärkkäinen, Virve; Andberg, Sami; Hannonen, Sanna; Rusanen, Minna; Saari, Toni; Korhonen, Ville; Hokkanen, Laura; Hallikainen, Merja; Hänninen, Tuomo; Kaarniranta, Kai; Bednarik, Roman; Leinonen, Ville; Koivisto, Anne M, 2022, Alzheimer disease and associated disorders, 36, 4, 340-346. A1 Journal article (refereed), original research
ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J, 2016, Molecular neurodegeneration, 11, 10. A1 Journal article (refereed), original research
Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J, 2016, Molecular neurodegeneration, 11, 15. A1 Journal article (refereed), original research
Metabotropic glutamate receptor 5 responses dictate differentiation of neural progenitors to NMDA-responsive cells in fragile X syndrome
Achuta VS, Grym H, Putkonen N, Louhivuori V, Kärkkäinen V, Koistinaho J, Roybon L, Castrén ML, 2016, Developmental neurobiology, [Epub ahead of print 28 July 2016], 1-16. A1 Journal article (refereed), original research
Nrf2 regulates neurogenesis and protects neural progenitor cells against aß toxicity
Kärkkäinen Virve, Pomeshchik Yuriy, Savchenko Ekaterina, Dhungana Hiramani, Kurronen Antti, Lehtonen Sarka, Naumenko Nikolay, Tavi Pasi, Levonen Anna-Liisa, Yamamoto Masayaki, Malm Tarja, Magga Johanna, Kanninen Katja M, Koistinaho Jari, 2014, Stem cells, 32, 7, 1904-1916. A1 Journal article (refereed), original research
Brain Environment and Alzheimer's Disease Mutations Affect the Survival, Migration and Differentiation of Neural Progenitor Cells
Kärkkäinen V, Magga J, Koistinaho J, Malm T, 2012, Current alzheimer research, 2012 Aug 30. [Epub ahead of print]. A1 Journal article (refereed), original research