ANNA-LIISA LEVONEN

Yhteystiedot

Julkaisut

• Cedo, Lidia; Metso, Jari; Santos, David; García-León, Annabel; Plana, Nuria; Sabate-Soler, Sonia; Rotllan, Noemi; Rivas-Urbina, Andrea; Mendez-Lara, Karen A; Tondo, Mireia; Girona, Josefa; Julve, Josep; Pallarès, Victor; Benitez-Amado, Aleyda; Llorente Cortes, Vicenta; Pérez, Antonio; Gómez-Coronado, Diego; Ruotsalainen, Anna-Kaisa; Levonen, Anna-Liisa; Sanchez-Quesada, Jose Luis et al.. 2020. LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis: Insight from Mouse Models Circulation research [Online ahead of print]: -. 2020
• Küblbeck, Jenni; Vuorio, Taina; Niskanen, Jonna; Fortino, Vittorio; Braeunin, Albert; Abass, Khaled; Rautio, Arja; Hakkola, Jukka; Honkakoski, Paavo; Levonen, Anna-Liisa. 2020. The EDCMET project: Metabolic effects of endocrine disruptors International journal of molecular sciences 21 8: 3021. 2020
• Linna-Kuosmanen, Suvi; Bosch, Vanesa Tomas; Moreau, Pierre R; Bouvy-Liivrand, Maria; Niskanen, Henri; Kansanen, Emilia; Kivelä, Annukka; Hartikainen, Juha; Hippeläinen, Mikko; Kokki, Hannu; Tavi, Pasi; Levonen, Anna-Liisa; Kaikkonen, Minna U. 2020. NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli Cardiovascular research [Online ahead of print]: -. 2020
• Arasu, UT; Deen, AJ; Pasonen-Seppänen, S; Heikkinen, S; Lalowski, M; Kärnä, R; Härkönen, K; Mäkinen, P; Lázaro-Ibáñez, E; Siljander, PR; Oikari, S; Levonen, AL; Rilla, K. 2019. HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells Cellular and molecular life sciences [Published: 09 December 2019]: 1-23. 2019
• Cuadrado, A; Rojo, AI; Wells, G; Hayes, JD; Cousin, SP; Rumsey, WL; Attucks, OC; Franklin, S; Levonen, AL; Kensler, TW; Dinkova-Kostova, AT. 2019. Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases Nature reviews drug discovery 18: 295-317. 2019
• Jauhiainen, Suvi; Laakkonen, Johanna P; Ketola, Kirsi; Toivanen, Pyry, I; Nieminen, Tina; Ninchoji, Takeshi; Levonen, Anna-Liisa; Kaikkonen, Minna U; Ylä-Herttuala, Seppo. 2019. Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function Frontiers in physiology 10: 224. 2019
• Lipponen, A; Natunen, T; Hujo, M; Ciszek, R; Hämäläinen, E; Tohka, J; Hiltunen, M; Paananen, J; Poulsen, D; Kansanen, E; Ekolle Ndode-Ekane, X; Levonen, AL; Pitkänen, A. 2019. In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury - Lessons Learned International journal of molecular sciences 20 21: 5395. 2019
• Oksanen, M; Hyötyläinen, I; Trontti, K; Rolova, T; Wojciechowski, S; Koskuvi, M; Viitanen, M; Levonen, AL; Hovatta, I; Roybon, L; Lehtonen, Š; Kanninen, KM; Hämäläinen, RH; Koistinaho, J. 2019. NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes Glia 2020; 68 3: 589-599. 2019
• Patinen, Tommi; Adinolfi, Simone; Cortés, Carlos Cruz; Härkönen, Jouni; Jawahar Deen, Ashik; Levonen, Anna-Liisa. 2019. Regulation of stress signaling pathways by protein lipoxidation Redox biology 23: 1-8. 2019
• Pölönen, P; Jawahar Deen, A; Leinonen, HM; Jyrkkänen, HK; Kuosmanen, S; Mononen, M; Jain, A; Tuomainen, T; Pasonen-Seppänen, S; Hartikainen, JM; Mannermaa, A; Nykter, M; Tavi, P; Johansen, T; Heinäniemi, M; Levonen, AL. 2019. Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma Oncogene 38: 7473-7490. 2019
• Weisell, J; Ruotsalainen, AK; Laakso, H; Ylä-Herttuala, E; Näpänkangas, J; Levonen, AL; Liimatainen, T; Rysä, J. 2019. Characterizing valve dynamics in mice by high-resolution cine-MRI Nmr in biomedicine 32 8: e4108. 2019
• Deen, Ashik Jawahar; Sihvola, Virve; Härkönen, Jouni; Patinen, Tommi; Adinolfi, Simone; Levonen, Anna-Liisa. 2018. Regulation of stress signaling pathways by nitro-fatty acids Nitric oxide 78: 170-175. 2018
• Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. 2018. Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration Redox biology 2019; 20: 1-12. 2018
• Kuosmanen, SM; Sihvola, V; Kansanen, E; Kaikkonen, MU; Levonen, AL. 2018. MicroRNAs mediate the senescence-associated decline of NRF2 in endothelial cells Redox Biology 18: 77-83. 2018
• Ruotsalainen, Anna-Kaisa; Lappalainen, Jari P; Heiskanen, Emmi; Merentie, Mari; Näpänkangas, Juha; Lottonen-Raikaslehto, Line; Kansanen, Emilia; Adinolfi, Simone; Kaarniranta, Kai; Ylä-Herttuala, Seppo; Jauhiainen, Matti; Pirinen, Eija; Levonen, Anna-Liisa. 2018. Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolemic mice CARDIOVASCULAR RESEARCH 2019; 115 1: 243-254. 2018
• Nurmi K, Kareinen I, Virkanen J, Rajamäki K, Kouri VP, Vaali K, Levonen AL, Fyhrquist N, Matikainen S, Kovanen PT, Eklund KK. 2017. Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy: A Novel Mechanism of Inflammasome Regulation. Journal of Innate Immunity 9 1: 65-82. 2017
• Kuosmanen Suvi M, Kansanen Emilia, Sihvola Virve, Levonen Anna-Liisa. 2017. MicroRNA Profiling Reveals Distinct Profiles for Tissue-Derived and Cultured Endothelial Cells. Scientific Reports 7: 10943. 2017
• Kuosmanen SM, Kansanen E, Kaikkonen MU, Sihvola V, Pulkkinen K, Jyrkkänen H-K, Tuoresmäki P, Hartikainen J, Hippeläinen M, Kokko H, Tavi P, Heikkinen S, Levonen A-M. 2017. NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation. NUCLEIC ACIDS RESEARCH 2018; 46 3: 1124-1138. 2017
• Kansanen Emilia, Kuosmanen Suvi M, Ruotsalainen Anna-Kaisa, Hynynen Heidi, Levonen Anna-Liisa. 2017. Nitro-Oleic Acid Regulates Endothelin Signaling in Human Endothelial Cells. MOLECULAR PHARMACOLOGY 92 4: 481-490. 2017
• Abushik PA, Bart G, Korhonen P, Leinonen H, Giniatullina R, Sibarov DA, Levonen A-L , Malm T, Antonov SM, Giniatullin R. 2016. Pro-nociceptive migraine mediator CGRP provides neuroprotection of sensory, cortical and cerebellar neurons via multi-kinase signaling Cephalalgia 2017; 37 14: 1373-1383. 2016
• Kuosmanen Suvi M, Viitala Sari, Laitinen Tuomo, Peräkylä Mikael, Pölönen Petri, Kansanen Emilia, Leinonen Hanna, Raju Suresh, Wienecke-Baldacchino Anke, Närvänen Ale, Poso Antti, Heinäniemi Merja, Heikkinen Sami, Levonen Anna-Liisa. 2016. The Effects of Sequence Variation on Genome-wide NRF2 Binding - New Target Genes and Regulatory SNPs. NUCLEIC ACIDS RESEARCH 44 4: 1760-1775. 2016
• Liddell Jeffrey R, Lehtonen Sarka, Duncan Clare, Keksa-Goldsteine Velta, Levonen Anna-Liisa, Goldsteins Gundars, Malm Tarja, White Anthony R, Koistinaho Jari, Kanninen Katja M. 2016. Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 13 49: 1-14. 2016
• Pölönen P, Levonen A-L. 2016. Insights into the role of NRF2 in cancer provided by cancer genomics. Current Opinion in Toxicology 1: 111-117. 2016
• Sihvola Virve, Levonen Anna-Liisa. 2016. Keap1 as the redox sensor of the antioxidant response. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 2017; 617: 94-100. 2016
• Leinonen Hanna M, Kansanen Emilia, Polonen Petri, Heinaniemi Merja, Levonen Anna-Liisa. 2015. Dysregulation of the Keap1-Nrf2 pathway in cancer. BIOCHEMICAL SOCIETY TRANSACTIONS 43 4: 645-649. 2015
• Kuosmanen Suvi M, Hartikainen Juha, Hippeläinen Mikko, Kokki Hannu, Levonen Anna-Liisa, Tavi Pasi. 2015. MicroRNA profiling of pericardial fluid samples from patients with heart failure. PLOS ONE [ONLINE] 10 3: e0119646. 2015
• Kansanen Emilia, Levonen Anna-Liisa. 2015. Oxidized and Nitrated Lipid Interactions with the Keap1-Nrf2 Pathway. Teoksessa: Corinne M. Spickett, Henry Jay Forman (toim.) Lipid Oxidation in Health and Disease. CRC PRESS. s. 255-277. 2015
• Kanninen Katja M, Pomeshchik Yuriy, Leinonen Hanna, Malm Tarja, Koistinaho Jari, Levonen Anna-Liisa. 2015. Applications of the Keap1-Nrf2 system for gene and cell therapy. FREE RADICAL BIOLOGY & MEDICINE 88 Part B: 350-361. 2015
• Kärkkäinen Virve, Pomeshchik Yuriy, Savchenko Ekaterina, Dhungana Hiramani, Kurronen Antti, Lehtonen Sarka, Naumenko Nikolay, Tavi Pasi, Levonen Anna-Liisa, Yamamoto Masayaki, Malm Tarja, Magga Johanna, Kanninen Katja M, Koistinaho Jari. 2014. Nrf2 regulates neurogenesis and protects neural progenitor cells against aß toxicity. STEM CELLS 32 7: 1904-1916. 2014
• Leinonen Hanna M, Kansanen Emilia, Pölönen Petri, Heinäniemi Merja, Levonen Anna-Liisa. 2014. Role of the Keap1-Nrf2 pathway in cancer. Advances in cancer research 2014;122: 281-320. 2014
• Levonen AL, Hill BG, Kansanen E, Zhang J, Darley-Usmar VM. 2014. Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics. FREE RADICAL BIOLOGY & MEDICINE 71: 196-207. 2014
• Levonen Anna-Liisa. 2014. Activation of stress signaling pathways by oxidized and nitrated lipids. FREE RADICAL BIOLOGY & MEDICINE 75 Suppl 1: S8. 2014
• Paakinaho Ville, Kaikkonen Sanna, Levonen Anna-Liisa, Palvimo Jorma J. 2014. Electrophilic Lipid Mediator 15-Deoxy-Delta12,14-Prostaglandin J2 Modifies Glucocorticoid Signaling via Receptor SUMOylation. MOLECULAR AND CELLULAR BIOLOGY 34 17: 3202-13. 2014
• Savinainen Juha R, Kansanen Emilia, Pantsar Tatu, Navia-Paldanius Dina, Parkkari Teija, Lehtonen Marko, Laitinen Tuomo, Nevalainen Tapio, Poso Antti, Levonen Anna-Liisa, Laitinen Jarmo T. 2014. Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL). MOLECULAR PHARMACOLOGY Epub ahead of print: -. 2014
• Ruotsalainen AK, Inkala M, Partanen ME, Lappalainen JP, Kansanen E, Mäkinen PI, Heinonen SE, Laitinen HM, Heikkilä J, Vatanen T, Hörkkö S, Yamamoto M, Ylä-Herttuala S, Jauhiainen M, Levonen AL. 2013. The absence of macrophage Nrf2 promotes early atherogenesis. CARDIOVASCULAR RESEARCH 2013 Apr 1;98(1): 107-15. 2013
• Kansanen Emilia, Kuosmanen Suvi M, Leinonen Hanna, Levonen Anna-Liisa. 2013. The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer. Redox Biology Volume 1, Issue 1, 2013: 45-49. 2013
• Pomeshchik Y, Kidin I, Savchenko E, Rolova T, Yamamoto M, Levonen AL, Ylä-Herttuala S, Malm T, Kanninen K, Koistinaho J. 2013. Does Nrf2 Gene Transfer Facilitate Recovery After Contusion Spinal Cord Injury?. ANTIOXIDANTS AND REDOX SIGNALING 2013 Aug 20. [Epub ahead of print]: x-x. 2013
• Frösen J, Tulamo R, Heikura T, Sammalkorpi S, Niemelä M, Hernesniemi J, Levonen AL, Hörkkö S, Ylä-Herttuala S. 2013. Lipid accumulation, lipid oxidation, and low plasma levels of acquired antibodies against oxidized lipids associate with degeneration and rupture of the intracranial aneurysm wall. Acta neuropathologica communications 1: 71. 2013
• Hammond VJ, Morgan AH, Lauder SN, Thomas CP, Brown S, Freeman BA, Lloyd C, Davies J, Bush A, Levonen AL, Kansanen E, Villacorta L, Chen YE, Porter N, Garcia Diaz YM, Schopfer F, O'Donnell VB. 2012. Novel keto-phospholipids are generated by monocytes and macrophages, detected in Cystic Fibrosis, and activate peroxisome proliferator-activated receptor-γ. JOURNAL OF BIOLOGICAL CHEMISTRY 2012 Oct 11. [Epub ahead of print]: --. 2012
• Kaikkonen S, Paakinaho V, Sutinen P, Levonen AL, Palvimo JJ. 2012. Prostaglandin 15d-PGJ(2) inhibits androgen receptor signaling in prostate cancer cells. MOLECULAR ENDOCRINOLOGY --: e1-12. 2012
• Kivelä AM, Dijkstra MH, Heinonen SE, Gurzeler E, Jauhiainen S, Levonen AL, Ylä-Herttuala S. 2012. Regulation of endothelial lipase and systemic HDL cholesterol levels by SREBPs and VEGF-A. ATHEROSCLEROSIS 2012 Oct 9. [Epub ahead of print] pii: S0021-9150(12)00657-0.: --. 2012
• Leinonen HM, Ruotsalainen AK, Määttä AM, Laitinen HM, Kuosmanen SM, Kansanen E, Pikkarainen JT, Lappalainen JP, Samaranayake H, Lesch HP, Kaikkonen MU, Ylä-Herttuala S, Levonen AL. 2012. Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment. CANCER RESEARCH 2012 Oct 9. [Epub ahead of print]: - -. 2012
• Lämsä V, Levonen AL, Sormunen R, Yamamoto M, Hakkola J. 2012. Heme and Heme Biosynthesis Intermediates Induce Heme Oxygenase-1 and Cytochrome P450 2A5, Enzymes With Putative Sequential Roles in Heme and Bilirubin Metabolism: Different Requirement for Transcription Factor Nuclear Factor Erythroid- Derived 2-like 2. TOXICOLOGICAL SCIENCES 2012 Nov;130(1): 132-44. 2012
• Jauhiainen Suvi, Häkkinen Sanna-Kaisa, Toivanen Pyry I, Heinonen Suvi E, Jyrkkänen Henna-Kaisa, Kansanen Emilia, Leinonen Hanna, Levonen Anna-Liisa, Ylä-Herttuala Seppo. 2011. Vascular endothelial growth factor (VEGF)-D stimulates VEGF-A, stanniocalcin-1, and neuropilin-2 and has potent angiogenic effects. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 31: 1617-1624. 2011
• Jyrkkänen HK, Kuosmanen S, Heinäniemi M, Laitinen H, Kansanen E, Mella-Aho E, Leinonen H, Ylä-Herttuala S, Levonen AL. 2011. Novel insights into the regulation of antioxidant-response-element-mediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by Nrf2 BIOCHEMICAL JOURNAL 2011 Dec 1;440(2): 167-74. 2011
• Kansanen Emilia, Bonacci Gustavo, Schopfer Francisco J, Kuosmanen Suvi M, Tong Kit I, Leinonen Hanna, Woodcock Steven R, Yamamoto Masayuk, Carlberg Carsten, Ylä-Herttuala Seppo, Freeman Bruce A, Levonen Anna-Liisa. 2011. Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism. JOURNAL OF BIOLOGICAL CHEMISTRY 286: 14019-14027. 2011
• Pulkkinen KH, Ylä-Herttuala S, Levonen AL. 2011. Heme oxygenase 1 is induced by miR-155 via reduced BACH1 translation in endothelial cells FREE RADICAL BIOLOGY & MEDICINE 2011 Dec 1;51(11): 2124-31. 2011
• Veneskoski M, Turunen SP, Kummu O, Nissinen A, Rannikko S, Levonen AL, Hörkkö S. 2011. Specific recognition of malondialdehyde and malondialdehyde acetaldehyde adducts on oxidized LDL and apoptotic cells by complement anaphylatoxin C3a. FREE RADICAL BIOLOGY & MEDICINE 2011 Aug 15;51(4): 834-43. 2011
• Kansanen E, Jyrkkänen HK, Levonen AL. 2011. Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids. FREE RADICAL BIOLOGY & MEDICINE 2012 Mar 15;52(6 2011 Dec 13. [Epub ahead of print]: 973-82. 2011
• Bochkov VN, Oskolkova OV, Birukov KG, Levonen AL, Binder CJ & Stöckl J. 2010. Generation and biological activities of oxidized phospholipids. ANTIOXIDANTS AND REDOX SIGNALING 12: 1009-1059. 2010
• Kivelä AM, Mäkinen PI, Jyrkkänen HK, Mella-Aho E, Xia Y, Kansanen E, Leinonen H, Verma IM, Ylä-Herttuala S & Levonen AL. 2010. Sulforaphane inhibits endothelial lipase expression through NF-κB in endothelial cells. ATHEROSCLEROSIS 213: 122-128. 2010
• Lämsä V, Levonen AL, Leinonen H, Ylä-Herttuala S, Yamamoto M & Hakkola J. 2010. Cytochrome P450 2A5 constitutive expression and induction by heavy metals is dependent on redox-sensitive transcription factor Nrf2 in liver. CHEMICAL RESEARCH IN TOXICOLOGY 23: 977-985. 2010
• Karvinen H, Rutanen J, Leppänen O, Lach R, Levonen A-L, Eriksson U, Ylä-Herttuala S. 2009. PDGF-C and -D and their receptors PDGFR-alpha and PDGFR-beta in atherosclerotic human arteries. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 39 4: 320-327. 2009
• Loboda A, Stachurska A, Florczyk U, Rudnicka D, Jazwa A, Wegrzyn J, Kozakowska M, Stalinska K, Poellinger L, Levonen A-L, Yla-Herttuala S, Jozkowicz A, Dulak J. 2009. HIF-1 induction attenuates Nrf2-dependent IL-8 expression in human endothelial cells. ANTIOXIDANTS AND REDOX SIGNALING 11: 1501-1517. 2009
• Kansanen E, Jyrkkänen H-K, Volger OL, Leinonen H, Kivelä AM, Häkkinen S-K, Woodcock SR, Schopfer FJ, Horrevoets AJ, Ylä-Herttuala S, Freeman BA, Levonen A-L. 2009. Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid. JOURNAL OF BIOLOGICAL CHEMISTRY 284 48: 33233-33241. 2009
• Kansanen E, Kivelä AM, Levonen A-L. 2009. Regulation of Nrf2-dependent gene expression by 15-deoxy-Delta12,14-prostaglandin J2. FREE RADICAL BIOLOGY & MEDICINE 47: 1310-1317. 2009
• Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J. 2009. Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106 38: 16505-16510. 2009
• Fledderus JO, Boon RA, Volger OL, Hurttila H, Ylä-Herttuala S, Pannekoek H, Levonen A-L, Horrevoets AJG. 2008. KLF2 primes the antioxidant transcription factor Nrf2 for activation in endothelial cells. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 28: 1339-1346. 2008
• Hurttila H, Koponen JK, Kansanen E, Jyrkkänen H-K, Kivelä A, Kylätie R, Ylä-Herttuala S, Levonen A-L. 2008. Oxidative stress-inducible lentiviral vectors for gene therapy. GENE THERAPY 15: 1271-1279. 2008
• Jyrkkänen H-K, Kansanen E, Inkala M, Kivelä AM, Hurttila H, Heinonen SE, Goldsteins G, Jauhiainen S, Tiainen S, Makkonen H, Oskolkova O, Afonyushkin T, Koistinaho J, Yamamoto M, Bochkov VN, Ylä-Herttuala S, Levonen A-L. 2008. Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo CIRCULATION RESEARCH [ONLINE: HTTP://CIRCRES.AHAJOURNALS.ORG/] 103: e1-e9. 2008
• Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL, Koistinaho J. 2008. Nuclear factor erythroid 2-related factor 2 protects against beta amyloid. MOLECULAR AND CELLULAR NEUROSCIENCE (SAN DIEGO CA) 39 3: 302-313. 2008
• Kivelä AM, Kansanen E, Jyrkkänen HK, Nurmi T, Ylä-Herttuala S, Levonen AL. 2008. Enterolactone induces heme oxygenase-1 expression through nuclear factor-E2-related factor 2 activation in endothelial cells. JOURNAL OF NUTRITION 138: 1263-1268. 2008
• Levonen A-L, Vähäkangas E, Koponen JK, Ylä-Herttuala S. 2008. Antioxidant gene therapy for cardiovascular disease: current status and future perspectives. CIRCULATION 117: 2142-2150. 2008
• Tuomisto TT, Lumivuori H, Kansanen E, Häkkinen S-K, Turunen MP, van Thienen JV, Horrevoets AJ, Levonen A-L, Ylä-Herttuala S. 2008. Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2. CARDIOVASCULAR RESEARCH 78 1: 175-184. 2008
• Bräsen JH, Leppänen O, Inkala M, Heikura T, Levin M, Ahrens F, Rutanen J, Pietsch H, Bergqvist D, Levonen A-L, Basu S, Zeller T, Klöppel G, Laukkanen MO, Ylä-Herttuala S. 2007. Extracellular superoxide dismutase accelerates endothelial recovery and inhibits in-stent restenosis in stented atherosclerotic Watanabe heritable hyperlipidemic rabbit aorta. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 50 23: 2249-2253. 2007
• Levonen A-L, Inkala M, Heikura T, Jauhiainen S, Jyrkkänen H-K, Kansanen E, Määttä K, Romppanen E, Turunen P, Rutanen J, Ylä-Herttuala S. 2007. Nrf2 gene transfer induces antioxidant enzymes and suppresses smooth muscle cell growth in vitro and reduces oxidative stress in rabbit aorta in vivo. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 27: 741-747. 2007
• Pirinen E, Kuulasmaa T, Pietilä M, Heikkinen S, Tusa M, Itkonen P, Boman S, Skommer J, Virkamäki A, Hohtola E, Kettunen M, Fatrai S, Kansanen E, Koota S, Niiranen K, Parkkinen J, Levonen A-L, Ylä-Herttuala S, Hiltunen JK, Alhonen L, Smith U, Jänne J. 2007. Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism MOLECULAR AND CELLULAR BIOLOGY 27 13: 4953-4967. 2007
• Landar A, Shiva S, Levonen A-L, Oh J-Y, Zaragoza C, Johnson MS, Darley-Usmar VM. 2006. Induction of the permeability transition and cytochrome c release by 15-deoxy-delta12,14-prostaglandin J2 in mitochondria BIOCHEMICAL JOURNAL 394: 185-195. 2006
• Tuomisto TT, Riekkinen MS, Viita H, Levonen A-L, Ylä-Herttuala S. 2005. Analysis of gene and protein expression during monocyte-macrophage differentation and cholesterol loading - cDNA and protein array study. ATHEROSCLEROSIS 180 2: 283-291. 2005
• Ahola T, Levonen A-L, Fellman V, Lapatto R. 2004. Thiol metabolism in preterm infants during the first week of life. SCANDINAVIAN JOURNAL OF CLINICAL AND LABORATORY INVESTIGATION 64: 649-658. 2004
• Dickinson DA, Levonen A-L, Moellering DR, Arnold EK, Zhang H, Darley-Usmar VM, Forman HJ. 2004. Human glutamate cysteine ligase gene regulation through the electrophile response element. FREE RADICAL BIOLOGY & MEDICINE 37 8: 1152-1159. 2004

Tutkimusryhmät

• EDCMET
• Redox signalointi (Anna-Liisa Levosen ryhmä)