Anu Kauppinen

Bhattarai, Niina; Korhonen, Eveliina; Mysore, Yashavanthi; Kaarniranta, Kai; Kauppinen, Anu. 2021. Hydroquinone Induces NLRP3-Independent IL-18 Release from ARPE-19 Cells Cells 10 6: 1405. 2021

Ranta-aho, Sofia; Piippo, Niina; Korhonen, Eveliina; Kaarniranta, Kai; Hytti, Maria; Kauppinen, Anu. 2021. TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells International journal of molecular sciences 22 9: 4875. 2021

Sridevi Gurubaran, Iswariyaraja; Heloterä, Hanna; Marry, Stephen; Koskela, Ali; Hyttinen, Juha MT; Paterno, Jussi J; Urtti, Arto; Chen, Mei; Xu, Heping; Kauppinen, Anu; Kaarniranta, Kai. 2021. Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1[alpha] -/- Mouse Model Evoke Complement Component C5a Independent of C3 Biology 10 7: 622. 2021

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2021. Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases Inflammation research 70 10-12: 1043-1061. 2021

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2021. Hypoxia/ischemia impairs CD33 (Siglec-3)/TREM2 signaling: Potential role in Alzheimer's pathogenesis Neurochemistry international 150: 105186. 2021

Bhattarai, Niina; Piippo, Niina; Ranta-aho, Sofia; Mysore, Yashavanthi; Kaarniranta, Kai; Kauppinen, Anu. 2021. Effects of Resvega on Inflammasome Activation in Conjunction with Dysfunctional Intracellular Clearance in Retinal Pigment Epithelial (RPE) Cells Antioxidants 10 1: 67. 2021

Mysore, Yashavanthi; del Amo, Eva M; Loukovaara, Sirpa; Hagström, Marja; Urtti, Arto; Kauppinen, Anu. 2021. Statins for the prevention of proliferative vitreoretinopathy: cellular responses in cultured cells and clinical statin concentrations in the vitreous Scientific reports 11 1: 980. 2021

Hytti, Maria; Korhonen, Eveliina; Hongisto, Heidi; Kaarniranta, Kai; Skottman, Heli; Kauppinen, Anu. 2021. Differential Expression of Inflammasome-Related Genes in Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells with or without History of Age-Related Macular Degeneration International journal of molecular sciences 22 13: 6800. 2021

Korhonen, Eveliina; Hytti, Maria; Piippo, Niina; Kaarniranta, Kai; Kauppinen, Anu. 2021. Antimycin A-induced mitochondrial dysfunction regulates inflammasome signaling in human retinal pigment epithelial cells Experimental eye research 209: 108687. 2021

Klionsky, Daniel J; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; Abildgaard, Marie H; Abudu, Yakubu Princely; Acevedo-Arozena, Abraham; Adamopoulos, Iannis E; Adeli, Khosrow; Adolph, Timon E; Adornetto, Annagrazia; Aflaki, Elma; Agam, Galila; Agarwal, Anupam; Aggarwal, Bharat B; Agnello, Maria; Agostinis, Patrizia et al. [Incl. Ha. 2021. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) Autophagy 17 1: 1-382. 2021

Kauppinen, Anu. 2020. Introduction to the multi-author review on macular degeneration Cellular and molecular life sciences 77 5: 779-780. 2020

Kauppinen, Anu; Kaarniranta, Kai; Salminen, Antero. 2020. Potential Role of Myeloid-Derived Suppressor Cells (MDSCs) in Age-Related Macular Degeneration (AMD) Frontiers in immunology 11: 384. 2020

Korhonen, Eveliina; Bisevac, Jovana; Hyttinen, Juha MT; Piippo, Niina; Hytti, Maria; Kaarniranta, Kai; Petrovski, Goran; Kauppinen, Anu. 2020. UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells Investigative ophthalmology and visual science 61 4: 7. 2020

Korhonen, Eveliina; Piippo, Niina; Hytti, Maria; Hyttinen, Juha; Kaarniranta, Kai; Kauppinen, Anu. 2020. Only IL-1ß release is inflammasome-dependent upon ultraviolet B irradiation although IL-18 is also secreted Faseb journal 34 5: 6437-6448. 2020

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2020. ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease Journal of molecular medicine: jmm 98: 633-650. 2020

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2020. Exosomal vesicles enhance immunosuppression in chronic inflammation: Impact in cellular senescence and the aging process Cellular signalling 75: 109771. 2020

Sridevi Gurubaran, Iswariyaraja; Viiri, Johanna; Koskela, Ali; Hyttinen, Juha M; Paterno, Jussi; Kis, Gréta; Antal, Miklós; Urtti, Arto; Kauppinen, Anu; Felszeghy, Szabolcs; Kaarniranta, Kai. 2020. Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model International journal of molecular sciences 21 6: 1976. 2020

Theme issue on macular degeneration. Kauppinen, Anu. 2020 2020

Kaarniranta, Kai; Uusitalo, Hannu; Blasiak, Janusz; Felszeghy, Szabolcs; Kannan, Ram; Kauppinen, Anu; Salminen, Antero; Sinha, Debasish; Ferrington, Deborah. 2020. Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration Progress in retinal and eye research 78: 100858. 2020

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2019. Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency Cellular and molecular life sciences 76 10: 1901-1918. 2019

Zeiner, J; Loukovaara, S; Losenkova, K; Zuccarini, M; Korhonen, AM; Lehti, K; Kauppinen, A; Kaarniranta, K; Müller, CE; Jalkanen, S; Yegutkin, GG. 2019. Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage Journal of molecular medicine: jmm 97 3: 341-354. 2019

Szatmári-Tóth, M; Ilmarinen, T; Mikhailova, A; Skottman, H; Kauppinen, A; Kaarniranta, K; Kristóf, E; Lytvynchuk, L; Veréb, Z; Fésüs, L; Petrovski, G. 2019. Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium-Role in Dead Cell Clearance and Inflammation International journal of molecular sciences 20 4: 926. 2019

Salminen, Antero; Kauppinen, Anu; Kaarniranta, Kai. 2019. AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging Journal of molecular medicine: jmm 97 8: 1049-1064. 2019

Hytti, Maria; Korhonen, Eveliina; Hyttinen, Juha M T; Roehrich, Heidi; Kaarniranta, Kai; Ferrington, Deborah A; Kauppinen, Anu. 2019. Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy Oxidative medicine and cellular longevity 2019: 1583656. 2019

Resvega alleviates oxidative stress and inflammasome activation in retinal pigment epithelial cells. Bhattarai, Niina; Korhonen, Eveliina; Toppila, Maija; Kaarniranta, Kai; Kauppinen, Anu. Acta ophthalmologica. 2019. 2019

Korhonen, E; Piippo, N; Hytti, M; Hyttinen, JMT; Kaarniranta, K; Kauppinen, A. 2019. SQSTM1/p62 regulates the production of IL-8 and MCP-1 in IL-1ß-stimulated human retinal pigment epithelial cells Cytokine 116: 70-77. 2019

Kaarniranta, Kai; Koskela, Ali; Felszeghy, Szabolcs; Kivinen, Niko; Salminen, Antero; Kauppinen, Aanu. 2019. Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration Biochimie 159: 49-54. 2019

Aro, A; Kauppinen, A; Kivinen, N; Selander, T; Kinnunen, K; Tuomilehto, J; Keinänen-Kiukaanniemi, S; Lindström, J; Uusitupa, M; Kaarniranta, K. 2019. Life Style Intervention Improves Retinopathy Status - The Finnish Diabetes Prevention Study Nutrients 11 7: 1691. 2019

Piippo, Niina; Korhonen, Eveliina; Hytti, Maria; Kinnunen, Kati; Kaarniranta, Kai; Kauppinen, Anu. 2018. Oxidative Stress is the Principal Contributor to Inflammasome Activation in Retinal Pigment Epithelium Cells with Defunct Proteasomes and Autophagy Cellular physiology and biochemistry 49 1: 359-367. 2018

Salminen, Antero; Kauppinen, Anu; Kaarniranta, Kai. 2018. Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence Biogerontology 19 5: 325-329. 2018

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2018. The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process AGEING RESEARCH REVIEWS 48: 1-10. 2018

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2018. The potential importance of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of Alzheimer's disease Cellular and molecular life sciences 75 17: 3099-3120. 2018

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2018. Phytochemicals inhibit the immunosuppressive functions of myeloid-derived suppressor cells (MDSC): Impact on cancer and age-related chronic inflammatory disorders. International Immunopharmacology 61: 231-240. 2018

Piippo, N; Korhonen, E; Hytti, M; Skottman, H; Kinnunen, K; Josifovska, N; Petrovski, G; Kaarniranta, K; Kauppinen, A. 2018. Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome. Scientific Reports 8: 6720. 2018

Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. 2018. Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration Redox biology 2019; 20: 1-12. 2018

Marchesi, Nicoletta; Thongon, Natthakan; Pascale, Alessia; Provenzani, Alessandro; Koskela, Ali; Korhonen, Eveliina; Smedowski, Adrian; Govoni, Stefano; Kauppinen, Anu; Kaarniranta, Kai; Amadio, Marialaura. 2018. Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways Oxidative medicine and cellular longevity 2018: 4956080. 2018

Kaarniranta; Kai; Xu, Heping; Kauppinen, Anu. 2018. Mechanistical retinal drug targets and challenges Advanced drug delivery reviews 126: 177-184. 2018

Kauppinen, Anu. 2018. NLRP3-inflammasomiaktivaatio diabeettisessa retinopatiassa BestPractice: Diabetes ja sydänsairaudet 6 Nro 21. Maaliskuu 2018: -. 2018

Kinnunen K, Piippo N, Loukovaara S, Hytti M, Kaarniranta K, Kauppinen A. 2017. Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs). Journal of Cell Communication and Signaling 11 3: 275-279. 2017

Salminen Antero, Kaarniranta Kai, Kauppinen Anu. 2017. Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses. AGEING RESEARCH REVIEWS 37: 79-93. 2017

Loukovaara S, Piippo N, Kinnunen K, Hytti M, Kaarniranta K, Kauppinen A. 2017. NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy. ACTA OPHTHALMOLOGICA 95 8: 803-808. 2017

Kivinen Niko, Koskela Ali, Kauppinen Anu, Kaarniranta kai. 2017. Silmänpohjan ikärappeuman patogeneesi - autofagian ja inflammasomien vuoropuhelua. DUODECIM 133 7: 641-646. 2017

Salminen Antero, Kauppinen Anu, Kaarniranta Kai. 2017. Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease. JOURNAL OF NEUROCHEMISTRY 140 4: 536-549. 2017

Kauppinen Anu. 2017. Mitochondria-Associated Inflammasome Activation and Its Impact on Aging and Age-Related Diseases. Teoksessa: Fulop Tamas, Franceschi Claudio, Hirokawa Katsuiku, Pawelec Graham (toim.) Handbook of Immunosenescence : Basic Understanding and Clinical Implication. Springer. s. 1-20. 2017

Hytti M, Andjelic S, Josifovska N, Piippo N, Korhonen E, Hawlina M, Kaarniranta K, Nevalainen TJ, Petrovski G, Parkkari T, Kauppinen A. 2017. CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells. Scientific Reports 7 1: 16169. 2017

Kaarniranta Kai, Petrovski Goran, Kauppinen Anu. 2017. The Nobel Prized cellular target autophagy in eye diseases. ACTA OPHTHALMOLOGICA 95 4: 335-336. 2017

Arjamaa Olli, Aaltonen Vesa, Piippo Niina, Csont Tamás, Petrovski Goran, Kaarniranta Kai, Kauppinen Anu. 2017. Hypoxia and inflammation in the release of VEGF and interleukins from human retinal pigment epithelial cells. GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 255 9: 1757-1762. 2017

Salminen A, Kaarniranta K, Kauppinen A. 2017. Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity. CELLULAR SIGNALLING 40: 10-21. 2017

Hytti M, Szabó D, Piippo N, Korhonen E, Honkakoski P, Kaarniranta K, Petrovski G, Kauppinen A. 2017. Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cell. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 42: 37-42. 2017

Hyttinen JMT, Blasiak J, Niittykoski M, Kinnunen K, Kauppinen A, Salminen A, Kaarniranta K. 2017. DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells - Implications for age-related macular degeneration (AMD). AGEING RESEARCH REVIEWS 36: 64-77. 2017

Hytti Maria, Tokarz P, Määttä E, Piippo Niina, Korhonen Eveliina, Suuronen T, Honkakoski Paavo, Kaarniranta Kai, Lahtela-Kakkonen Maija, Kauppinen Anu. 2016. Inhibition of BET bromodomains alleviates inflammation in human RPE cells. BIOCHEMICAL PHARMACOLOGY 110-111: 71-79. 2016

Kauppinen Anu, Paterno Jussi J, Blasiak Janusz, Salminen Antero, Kaarniranta Kai. 2016. Inflammation and its role in age-related macular degeneration Cellular and molecular life sciences 73 9: 1765-1786. 2016

Salminen Antero, Kaarniranta Kai, Kauppinen Anu. 2016. Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways. AGEING RESEARCH REVIEWS 28: 15-26. 2016

Salminen Antero, Kaarniranta Kai, Kauppinen Anu. 2016. AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms. BIOGERONTOLOGY 17 4: 655-680. 2016

Salminen Antero, Kaarniranta Kai, Kauppinen Anu. 2016. Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases. Aging and disease 7 2: 180-200. 2016

Salminen Antero, Kauppinen Anu, Kaarniranta Kai. 2016. AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions. CELLULAR SIGNALLING 28 8: 887-895. 2016

Salminen Antero, Kauppinen Anu, Kaarniranta Kai. 2016. FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process. JOURNAL OF MOLECULAR MEDICINE 2017; 95 2: 123-131. 2016

Szatmári-Tóth M, Kristóf E, Veréb Z, Akhtar S, Facskó A, Fésus L, Kauppinen A, Kaarniranta K, Petrovski G. 2016. Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration. Cell Death and Disease 7 9: e2367. 2016

Trzeciecka Anna, Paterno J Jussi, Toropainen Elisa, Koskela Ali, Podracka Lucia, Korhonen Eveliina, Kauppinen Anu, Kaarniranta Kai, Smedowski Adrian. 2016. Long-term topical application of preservative-free prostaglandin analogues evokes macrophage infiltration in the ocular adnexa European journal of pharmacology 788: 12-20. 2016

Kivinen Niko, Felszeghy Szabolcs, Kinnunen Aino I, Setälä Niko, Aikio Mari, Kinnunen Kati, Sironen Reijo, Pihlajaniemi Taina, Kauppinen Anu, Kaarniranta Kai. 2016. Absence of collagen XVIII in mice causes age-related insufficiency in retinal pigment epithelium proteostasis. BIOGERONTOLOGY 17 4: 749-761. 2016

Salminen Antero, Haapasalo Annakaisa, Kauppinen Anu, Kaarniranta Kai, Soininen Hilkka, Hiltunen Mikko. 2015. Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape. PROGRESS IN NEUROBIOLOGY epub ahead of print 19 May 2015. 2015

Salminen Antero, Kauppinen Anu, Kaarniranta Kai. 2015. 2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process. CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS 72 20: 3897-3914. 2015

Hytti Maria, Piippo Niina, Salminen Antero, Honkakoski Paavo, Kaarniranta Kai, Kauppinen Anu. 2015. Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells. EXPERIMENTAL EYE RESEARCH 132: 208-215. 2015

Korhonen Eveliina, Rönkkö Seppo, Hillebrand Satu, Riikonen Joakim, Xu Wujun, Järvinen Kristiina, Lehto Vesa-Pekka, Kauppinen Anu. 2015. Cytotoxicity assessment of porous silicon microparticles for ocular drug delivery. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 2016; 100: 1-8. 2015

Hytti Maria, Piippo Niina, Korhonen Eveliina, Honkakoski Paavo, Kaarniranta Kai, Kauppinen Anu. 2015. Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation. Scientific Reports 5 17645 (2015). 2015

Kaarniranta Kai, Machalinska Anna, Veréb Zoltán, Salminen Antero, Petrovski Goran, Kauppinen Anu. 2014. Estrogen Signalling in the Pathogenesis of Age-Related Macular Degeneration. CURRENT EYE RESEARCH 2014: 1-8. 2014

Kinnunen Kati, Kauppinen Anu, Piippo Niina, Koistinen Arto, Toropainen Elisa, Kaarniranta Kai. 2014. Cationorm shows good tolerability on human HCE-2 corneal epithelial cell cultures. EXPERIMENTAL EYE RESEARCH 120: 82-89. 2014

Kivinen Niko, Hyttinen Juha MT, Viiri Johanna, Paterno Jussi, Felszheghy Szabolcs, Kauppinen Anu, Salminen Antero, Kaarniranta Kai. 2014. Hsp70 binds reversibly to proteasome inhibitor-induced protein aggregates and evades autophagic clearance in ARPE-19 cells Journal of biochemical and pharmacological research 2 1: 1-7. 2014

Penttilä E, Hyttinen JMT, Hytti M, Kauppinen A, Smirnov G, Tuomilehto H, Seppä J, Nuutinen J, Kaarniranta K. 2014. Upregulation of inflammatory genes in the nasal mucosa of patients undergoing endonasal dacryocystorhinostomy. Clinical Ophthalmology 8: 799-805. 2014

Piippo N, Korkmaz A, Hytti M, Kinnunen K, Salminen A, Atalay M, Kaarniranta K, Kauppinen A. 2014. Decline in cellular clearance systems induces inflammasome signaling in human ARPE-19 cells. BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR CELL RESEARCH 1843 12: 3038-3046. 2014

Salminen A, Kauppinen A, Kaarniranta K. 2014. Inflammaging Signaling in Health Span and Life Span Regulation: Next Generation Targets for Longevity: Irfan Rahman and Debasis Bagchi, Inflammation, Advancing Age and Nutrition: Research and Clinical Interventions. 323-332. 2014

Salminen Antero, Kaarniranta Kai, Hiltunen Mikko, Kauppinen Anu. 2014. Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process. JOURNAL OF MOLECULAR MEDICINE -: -. 2014

Salminen Antero, Kaarniranta Kai, Hiltunen Mikko, Kauppinen Anu. 2014. Krebs cycle dysfunction shapes epigenetic landscape of chromatin: Novel insights into mitochondrial regulation of aging process. CELLULAR SIGNALLING 26: 1598-1603. 2014

Salminen Antero, Kauppinen Anu, Hiltunen Mikko, Kaarniranta Kai. 2014. Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process. AGEING RESEARCH REVIEWS 16: 45-65. 2014

Yrjölä Sari, Sarparanta Mirkka, Airaksinen Anu J, Hytti Maria, Kauppinen Anu, Pasonen-Seppänen Sanna, Adinolfi Barbara, Nieri Paola, Manera Clementina, Keinänen Outi, Poso Antti, Nevalainen Tapio J, Parkkari Teija. 2014. Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 2015; 67: 85-96. 2014

Kauppinen Anu, Nevalainen Tapio, Hytti Maria, Salminen Antero, Kaarniranta Kai, Parkkari Teija. 2014. CB2 receptor as a potential target in age-related diseases. Journal of Biochemical and Pharmacological Research 2 1: 33-43. 2014

Salminen A, Kaarniranta K, Kauppinen A. 2013. Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process. AGEING RESEARCH REVIEWS 12: 520-534. 2013

Tokarz P, Kauppinen A, Kaarniranta K, Blasiak J. 2013. Oxidative DNA Damage and Proteostasis in Age-Related Macular Degeneration. Journal of Biochemical and Pharmacological Research 1 2: 106-113. 2013

Salminen A, Kauppinen A, Hiltunen M, Kaarniranta K. 2013. Epigenetic regulation of ASC/TMS1 expression: potential role in apoptosis and inflammasome function. CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS -: -. 2013

Salminen A, Kaarniranta K, Kauppinen A. 2013. Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 14: 3834-3859. 2013

Kaarniranta K, Sinha D, Blasiak J, Kauppinen A, Vereb Z, Salminen A, Boulton ME, Petrovski G. 2013. Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. AUTOPHAGY 9 7: 1-12. 2013

Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. 2013. Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome. PROGRESS IN NEUROBIOLOGY 106-107: 33-54. 2013

Klettner A, Kauppinen A, Blasiak J, Roider J, Salminen A, Kaarniranta K. 2013. Cellular and molecular mechanisms of age-related macular degeneration: From impaired autophagy to neovascularization. International Journal of Biochemistry & Cell Biology 45: 1457-1467. 2013

Kauppinen A, Suuronen T, Ojala J, Kaarniranta K, Salminen A. 2013. Antagonistic crosstalk between NF-kappaB and SIRT1 in the regulation of inflammation and metabolic disorders. CELLULAR SIGNALLING 25: 1939-1948. 2013

Kauppinen A, Salminen A, Kaarniranta K. 2013. Inflammation as a target of minocycline: special interest in the regulation of inflammasome signaling. INFLAMMASOME 1: 2-14. 2013

Blasiak J, Glowacki S, Kauppinen A, Kaarniranta K. 2013. Mitochondrial and nuclear DNA damage and repair in age-related macular degeneration. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 14 2: 2996-3010. 2013

Salminen A, Hyttinen JMT, Kauppinen A, Kaarniranta K. 2012. Context-dependent regulation of autophagy by IKK-NF-kappaB signaling: Impact on the aging process. International Journal of Cell Biology 2012 ID 849541: 15 pages. 2012

Salminen, A; Kaarniranta, K; Kauppinen, A. 2012. Inflammaging: disturbed interplay between autophagy and inflammasomes. AGING 4 3: 166-175. 2012

Salminen A, Ojala J, Kaarniranta K, Kauppinen A. 2012. Mitochondrial dysfunction and oxidative stress active inflammasomes: impact on the aging process and age-related diseases CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS 69: 2999-3013. 2012

Salminen A, Kauppinen A, Kaarniranta K. 2012. Phytochemicals suppress nuclear factor-kappaB signaling: impact on health span and the aging process CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE 15: 23-28. 2012

Salminen A, Kauppinen A, Kaarniranta K. 2012. Emerging role of NF-kappaB signaling in the induction of senescence-associated secretory phenotype (SASP) CELLULAR SIGNALLING 24: 835-845. 2012

Paimela, T; Ryhänen, T; Kauppinen, A; Marttila, L; Salminen, A; Kaarniranta, K. 2012. The preservative polyquaternium-1 increases cytoxicity and NF-kappaB linked inflammation in human corneal epithelial cells MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 18: 1189-1196. 2012

Mika Reinisalo, Tuomas Paimela, Tuomas Ryhänen, Anu Kauppinen, Ali Koskela, Tuula Soininen, Kai Kaarniranta, Reijo Karjalainen. 2012. Protective function of wood-derived stilbenes against oxidative stress and inflammation in ARPE-19 cells. Teoksessa: (toim.), XXVIth International Conference on Polyphenols, Polyphenols Communications 2012. ss. 501-502. 2012

Kauppinen Anu, Peräsaari Juha, Taivainen Antti, Kinnunen Tuure, Saarelainen Soili, Rytkönen-Nissinen Marja, Jeal Hayley, Jones Meinir, Virtanen Tuomas. 2012. Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen. Immunobiology 217 1: 8-12. 2012

Kauppinen A, Niskanen H, Suuronen T, Kinnunen K, Salminen A, Kaarniranta K. 2012. Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells - Implications for age-related macular degeneration (AMD) IMMUNOLOGY LETTERS 147: 29-33. 2012

Kaarniranta K, Kauppinen A, Blasiak J, Salminen A. 2012. Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration. Future Medicinal Chemistry 4 17: 2153-2161. 2012

Jauhonen H-M, Kauppinen A, Paimela T, Laihia JK, Leino L, Salminen A, Kaarniranta K. 2011. Cis-urocanic acid inhibits SAPK/JNK signaling pathway in UV-B exposed human corneal epithelial cells in vitro. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 17: 2311-2317. 2011

Nuutinen T, Suuronen T, Kauppinen A & Salminen A. 2010. Valproic acid stimulates clusterin expression in human astrocytes: Implications for Alzheimer's disease. NEUROSCIENCE LETTERS 475: 64-68. 2010

Salminen A, Kauppinen A, Hyttinen JMT, Toropainen E & Kaarniranta K. 2010. Endoplasmic reticulum stress in age-related macular degeneration: Trigger for neovascularization MOLECULAR MEDICINE TODAY 16 11-12: 535-542. 2010

Juntunen R, Liukko A, Taivainen A, Närvänen A, Durand G, Kauppinen A, Nieminen A, Rytkönen-Nissinen M, Saarelainen S, Maillère B, Virtanen T, Kinnunen T. 2009. Suboptimal recognition of a T cell epitope of the major dog allergen Can f 1 by human T cells. MOLECULAR IMMUNOLOGY 46: 3320-3327. 2009

Nuutinen T, Suuronen T, Kauppinen A, Salminen A. 2009. Clusterin: A forgotten player in Alzheimer's disease. BRAIN RESEARCH REVIEWS 61: 89-104. 2009

Salminen A, Kauppinen A, Suuronen T, Kaarniranta K, Ojala J. 2009. ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 6 41: [13 p.]. 2009

Salminen A, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. 2009. Inflammation in Alzheimer's disease: Amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors PROGRESS IN NEUROBIOLOGY 87: 181-194. 2009

Viiri J, Jauhonen HM, Kauppinen A, Ryhänen T, Paimela T, Hyttinen J, Sorri I, Laihia JK, Leino L, Kaarniranta K. 2009. Cis-urocanic acid suppresses UV-B-induced interleukin-6 and -8 secretion and cytotoxicity in human corneal and conjunctival epithelial cells in vitro MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 15: 1799-1805. 2009

Salminen A, Ojala J, Suuronen T, Kaarniranta K, Kauppinen A. 2008. Amyloid-beta oligomers set fire to inflammasomes and induce Alzherimer's pathology. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 12 6A: 2255-2262. 2008

Salminen A, Ojala J, Huuskonen J, Kauppinen A, Suuronen T, Kaarniranta K. 2008. Interaction of aging-associated signaling cascades: Inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1. CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS 65: 1049-1058. 2008

Salminen A, Huuskonen J, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. 2008. Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging. AGEING RESEARCH REVIEWS 7: 83-105. 2008

Salminen A, Kauppinen A, Suuronen T, Kaarniranta K. 2008. SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation?. BIOESSAYS 30: 939-942. 2008

Saarelainen SA, Kinnunen TT, Buhot C, Närvänen ATO, Kauppinen AK, Rytkönen-Nissinen MA, Maillere B, Virtanen TI. 2008. Immunotherapeutic potential of the immunodominant T-cell epitope of lipocalin allergen Bos d 2 and its analogues IMMUNOLOGY 123: 358-366. 2008

Saarelainen S, Rytkönen-Nissinen M, Rouvinen J, Taivainen A, Auriola S, Kauppinen A, Kinnunen T, Virtanen T. 2008. Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity. CLINICAL AND EXPERIMENTAL ALLERGY 38: 374-381. 2008

Immonen A, Kinnunen T, Sirven P, Taivainen A, Houitte D, Peräsaari J, Närvänen A, Saarelainen S, Rytkönen- Nissinen M, Maillere B, Virtanen T. 2007. The major horse allergen Equ c 1 contains one immunodominant region of T cell epitopes. CLINICAL AND EXPERIMENTAL ALLERGY 37: 939-947. 2007

Immonnen AK, Taivainen AH, Närvänen ATO, Kinnunen TT, Saarelainen SA, Rytkönen-Nissinen MA, Virtanen TI. 2007. Use of multiple peptides containing T cell epitopes is a feasible approach for peptide-based immunotherapy in Can f 1 allergy. IMMUNOLOGY 120: 38-46. 2007

Kinnunen T, Jutila K, Kwok WW, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Närvänen A, Taivainen A, Virtanen T. 2007. Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 119: 965-972. 2007

Kauppinen A. 2006. Lipocalin Allergen-Induced T Cell Response. Prospects for Peptide-Based Immunotherapy. Kuopion yliopiston julkaisuja D. Lääketiede. 2006

Immonen A, Farci S, Taivainen A, Partanen J, Pouvelle-Moratille S, Närvänen A, Kinnunen T, Saarelainen S, Rytkönen-Nissinen M, Maillere B, Virtanen T. 2005. T cell epitope-containing peptides of the major dog allergen can f 1 as candidates for allergen immunotherapy. JOURNAL OF IMMUNOLOGY (BALTIMORE) 175 6: 3614-3620. 2005

Kinnunen T, Kwock WW, Närvänen A, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Taivainen A, Virtanen T. 2005. Immunomodulatory potential of heteroclitic analogs of the dominant T-cell epitope of lipocalin allergen Bos d 2 on specific T cells. INTERNATIONAL IMMUNOLOGY (OXFORD) 17 12: 1573-1581. 2005

Kinnunen T, Taivainen A, Partanen J, Immonen A, Saarelainen S, Rytkönen-Nissinen M, Rautiainen J, Virtanen T. 2005. The DR4-DQ8 haplotype and a specific T cell receptor Vbeta T cell subset are associated with absence of allergy to Can f 1 CLINICAL AND EXPERIMENTAL ALLERGY 35: 797-803. 2005

Markkula SE, Salo HM, Immonen AK, Jokinen EI. 2005. Effects of short- and long-term ultraviolet B irradiation on the immune system of the common carp (Cyprinus carpio) PHOTOCHEMISTRY AND PHOTOBIOLOGY 81 3: 595-602. 2005

Saarelainen S, Taivainen A, Rytkönen-Nissinen M, Auriola S, Immonen A, Mäntyjärvi R, Rautiainen J, Kinnunen T, Virtanen T. 2004. Assessment of recombinant dog allergens Can f 1 and Can f 2 for the diagnosis of dog allergy CLINICAL AND EXPERIMENTAL ALLERGY 34: 1576-1582. 2004

Immonen A, Saarelainen S, Rautiainen J, Rytkönen-Nissinen M, Kinnunen T, Mäntyjärvi R, Virtanen T. 2003. Probing the mechanisms of low immunogenicity of a lipocalin allergen, Bos d 2, in a mouse model. CLINICAL AND EXPERIMENTAL ALLERGY 33: 834-841. 2003

Jokinen E. Ilmari, Salo Harri M, Markkula Eveliina S, Immonen Anu K, Aalton Tuula M. 2001. Ultraviolet B irradiation modulates the immune system of fish (Rutilus rutilus, Cyprinidae). Part III: Lymphocytes. PHOTOCHEMISTRY AND PHOTOBIOLOGY 73 5: 505-512. 2001

Jokinen EI, Salo HM, Markkula SE, Aaltonen TM, Immonen AK. 2000. Effects of ultraviolet light on immune parameters of the roach. TOXICOLOGY LETTERS 112-113: 303-310. 2000

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