Front page
People
Research groups
Projects
About

Suomi English

Front page
People
Research groups
Projects
About

Refine your search

Frontpage
People
Anu Kauppinen

Anu Kauppinen

Professor

School of Pharmacy, Faculty of Health Sciences

[email protected] | +358 40 355 3216

Information Publications

Research groups

Immuno-Ophthalmology 01.05.2012 -

Keywords

aging autophagy cell biology cell culture drug development eye eye research health immunology inflammasome inflammation mitochondria molecular biology research

Publications

135/135 items

Fibrotic Changes in Rhegmatogenous Retinal Detachment
Harju, Niina; Kauppinen, Anu; Loukovaara, Sirpa. 2025. International journal of molecular sciences. 26: A2 Review article, Literature review, Systematic review
Anti-inflammatory potential of simvastatin and amfenac in ARPE-19 cells; insights in preventing re-detachment and proliferative vitreoretinopathy after rhegmatogenous retinal detachment surgery
Harju, Niina; Hytti, Maria; Kolari, Onni; Nisula, Hilkka; Loukovaara, Sirpa; Kauppinen, Anu. 2024. International ophthalmology. 44: . 158 A1 Journal article (refereed), original research
Epithelial-mesenchymal Transition (EMT) and the Effect of Atorvastatin on it in ARPE-19 cells
Mysore, Yashavanthi; Hytti, Maria; Deen, Ashik Jawahar; Ranta-aho, Sofia; Piippo, Niina; Toppila, Maija; Loukovaara, Sirpa; Harju, Niina; Kauppinen, Anu. 2024. Cell biochemistry and biophysics. 82: 1523-1536 A1 Journal article (refereed), original research
Metformin Alleviates Inflammation and Induces Mitophagy in Human Retinal Pigment Epithelium Cells Suffering from Mitochondrial Damage
Toppila, Maija; Ranta-aho, Sofia; Kaarniranta, Kai; Hytti, Maria; Kauppinen, Anu. 2024. Cells. 13: A1 Journal article (refereed), original research
Simvastatin and amfenac act as immunomodulators during induced epithelial‐mesenchymal transition in ARPE‐19 cells
Harju (ex‐Bhattarai), Niina; Loukovaara, Sirpa; Kauppinen, Anu. 2024. Acta ophthalmologica abstract
The L-type amino acid transporter 1 enhances drug delivery to the mouse pancreatic beta cell line (MIN6)
Tampio, Janne; Montaser, Ahmed B.; Järvinen, Juulia; Lehtonen, Marko; Jalkanen, Aaro J.; Reinisalo, Mika; Kokkola, Tarja; Terasaki, Tetsuya; Laakso, Markku; Rysä, Jaana; Kauppinen, Anu; Huttunen, Kristiina M. 2024. European journal of pharmaceutical sciences. 203: A1 Journal article (refereed), original research
Tissue fibroblasts are versatile immune regulators: An evaluation of their impact on the aging process
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2024. Ageing research reviews. 97: A2 Review article, Literature review, Systematic review
Autophagy in the eye: from physiology to pathophysology
Liton, Paloma B; Boesze-Battaglia, Kathleen; Boulton, Michael E; Boya, Patricia; Ferguson, Thomas A; Ganley, Ian G; Kauppinnen, Anu; Laurie, Gordon W.; Mizushima, Noboru; Morishita, Hideaki; Russo, Rossella; Sadda, Jaya; Shyam, Rajalekshmy; Sinha, Debasish; Thompson, Debra A.; Zacks, David N.. 2023. Autophagy reports. 2: . 2178996 A2 Review article, Literature review, Systematic review
Cis-urocanic acid improves cell viability and suppresses inflammasome activation in human retinal pigment epithelial cells
Korhonen, Eveliina; Piippo, Niina; Hytti, Maria; Kaarniranta, Kai; Kauppinen, Anu. 2023. Biochemical pharmacology. 216: A1 Journal article (refereed), original research
Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients
Karema-Jokinen, Viivi; Koskela, Ali; Hytti, Maria; Hongisto, Heidi; Viheriälä, Taina; Liukkonen, Mikko; Torsti, Tommi; Skottman, Heli; Kauppinen, Anu; Nymark, Soile; Kaarniranta, Kai. 2023. Journal of biological chemistry. 299: A1 Journal article (refereed), original research
The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance
Toppila, Maija; Hytti, Maria; Korhonen, Eveliina; Ranta-aho, Sofia; Harju, Niina; Forsberg, Markus M.; Kaarniranta, Kai; Jalkanen, Aaro; Kauppinen, Anu. 2023. Antioxidants. 12: A1 Journal article (refereed), original research
Amfenac together with simvastatin reduces IL-8 and MCP-1 and increases VEGF release from ARPE-19 cells upon inflammatory conditions
Bhattarai, Niina; Hytti, Maria; Kolari, Onni; Nisula, Hilkka; Loukovaara, Sirpa; Kauppinen, Anu. 2022. Acta ophthalmologica abstract
Askeleita kohti verkkokalvon irtauman jälkeisen arven lääkkeellistä estoa
Loukovaara, Sirpa; Gucciardo, Erika; Korhonen, Ani; Öhman, Tiina; Kauppinen, Anu . 2022. Duodecim. 138: 408-418 A2 Review article, Literature review, Systematic review
Editorial: Regulation of inflammation and metabolism in retinal neurodegenerative disorders
Leinonen, Henri; Zhou, Tianwei Ellen; Ballios, Brian G.; Kauppinen, Anu; Fu, Zhongjie. 2022. Frontiers in neuroscience. 16: . 1102385 B1 Non-refereed journal articles
Epoxomicin, a Selective Proteasome Inhibitor, Activates AIM2 Inflammasome in Human Retinal Pigment Epithelium Cells
Sridevi Gurubaran, Iswariyaraja; Hytti, Maria; Kaarniranta, Kai; Kauppinen, Anu. 2022. Antioxidants. 11: A1 Journal article (refereed), original research
Hydroquinone increases risk for retinal pigment epithelial (RPE) cell degeneration
Bhattarai, Niina; Hytti, Maria; Mysore, Yashavanthi; Kaarniranta, Kai; Kauppinen, Anu. 2022. Acta ophthalmologica abstract
Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions
Bhattarai, Niina; Hytti, Maria; Reinisalo, Mika; Kaarniranta, Kai; Mysore, Yashavanthi; Kauppinen, Anu. 2022. Immunologic research. 70: 678-687 A1 Journal article (refereed), original research
L-type Amino Acid Transporter 1 Utilizing Ferulic Acid Derivatives Show Increased Drug Delivery in the Mouse Pancreas Along with Decreased Lipid Peroxidation and Prostaglandin Production
Tampio, Janne; Markowicz-Piasecka, Magdalena; Montaser, Ahmed; Rysä, Jaana; Kauppinen, Anu; Huttunen, Kristiina M. 2022. Molecular pharmaceutics. 19: 3806-3819 A1 Journal article (refereed), original research
Phloretin inhibits glucose transport and reduces inflammation in human retinal pigment epithelial cells
Hytti, Maria; Ruuth, Johanna; Kanerva, Iiris; Bhattarai, Niina; Pedersen, Maria L; Nielsen, Carsten U; Kauppinen, Anu. 2022. Molecular and cellular biochemistry. 2023; 478: 215-227 A1 Journal article (refereed), original research
Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2022. Inflammation research. 71: 817-831 A2 Review article, Literature review, Systematic review
Antimycin A-induced mitochondrial dysfunction regulates inflammasome signaling in human retinal pigment epithelial cells
Korhonen, Eveliina; Hytti, Maria; Piippo, Niina; Kaarniranta, Kai; Kauppinen, Anu. 2021. Experimental eye research. 209: 108687 A1 Journal article (refereed), original research
Differential Expression of Inflammasome-Related Genes in Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells with or without History of Age-Related Macular Degeneration
Hytti, Maria; Korhonen, Eveliina; Hongisto, Heidi; Kaarniranta, Kai; Skottman, Heli; Kauppinen, Anu. 2021. International journal of molecular sciences
Effects of Resvega on Inflammasome Activation in Conjunction with Dysfunctional Intracellular Clearance in Retinal Pigment Epithelial (RPE) Cells
Bhattarai, Niina; Piippo, Niina; Ranta-aho, Sofia; Mysore, Yashavanthi; Kaarniranta, Kai; Kauppinen, Anu. 2021. Antioxidants
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Klionsky, Daniel J; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; Abildgaard, Marie H; Abudu, Yakubu Princely; Acevedo-Arozena, Abraham; Adamopoulos, Iannis E; Adeli, Khosrow; Adolph, Timon E; Adornetto, Annagrazia; Aflaki, Elma; Agam, Galila; Agarwal, Anupam; Aggarwal, Bharat B; Agnello, Maria; Agostinis, Patrizia et al. [Incl. Haapasalo, Annakaisa; Leskelä, Stina; Kaarniranta, Kai; Kauppinen, Anu; Koskela, Ali]. 2021. Autophagy
Hydroquinone Induces NLRP3-Independent IL-18 Release from ARPE-19 Cells
Bhattarai, Niina; Korhonen, Eveliina; Mysore, Yashavanthi; Kaarniranta, Kai; Kauppinen, Anu. 2021. Cells
Hypoxia/ischemia impairs CD33 (Siglec-3)/TREM2 signaling: Potential role in Alzheimer's pathogenesis
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2021. Neurochemistry international
Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2021. Inflammation research
Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1[alpha] -/- Mouse Model Evoke Complement Component C5a Independent of C3
Sridevi Gurubaran, Iswariyaraja; Heloterä, Hanna; Marry, Stephen; Koskela, Ali; Hyttinen, Juha MT; Paterno, Jussi J; Urtti, Arto; Chen, Mei; Xu, Heping; Kauppinen, Anu; Kaarniranta, Kai. 2021. Biology
Statins for the prevention of proliferative vitreoretinopathy: cellular responses in cultured cells and clinical statin concentrations in the vitreous
Mysore, Yashavanthi; del Amo, Eva M; Loukovaara, Sirpa; Hagström, Marja; Urtti, Arto; Kauppinen, Anu. 2021. Scientific reports
TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells
Ranta-aho, Sofia; Piippo, Niina; Korhonen, Eveliina; Kaarniranta, Kai; Hytti, Maria; Kauppinen, Anu. 2021. International journal of molecular sciences
ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2020. Journal of molecular medicine: jmm
Exosomal vesicles enhance immunosuppression in chronic inflammation: Impact in cellular senescence and the aging process
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2020. Cellular signalling
Introduction to the multi-author review on macular degeneration
Kauppinen, Anu. 2020. Cellular and molecular life sciences
Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration
Kaarniranta, Kai; Uusitalo, Hannu; Blasiak, Janusz; Felszeghy, Szabolcs; Kannan, Ram; Kauppinen, Anu; Salminen, Antero; Sinha, Debasish; Ferrington, Deborah. 2020. Progress in retinal and eye research
Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model
Sridevi Gurubaran, Iswariyaraja; Viiri, Johanna; Koskela, Ali; Hyttinen, Juha M; Paterno, Jussi; Kis, Gréta; Antal, Miklós; Urtti, Arto; Kauppinen, Anu; Felszeghy, Szabolcs; Kaarniranta, Kai. 2020. International journal of molecular sciences
Only IL-1ß release is inflammasome-dependent upon ultraviolet B irradiation although IL-18 is also secreted
Korhonen, Eveliina; Piippo, Niina; Hytti, Maria; Hyttinen, Juha; Kaarniranta, Kai; Kauppinen, Anu. 2020. Faseb journal
Potential Role of Myeloid-Derived Suppressor Cells (MDSCs) in Age-Related Macular Degeneration (AMD)
Kauppinen, Anu; Kaarniranta, Kai; Salminen, Antero. 2020. Frontiers in immunology
Theme issue on macular degeneration
Kauppinen, Anu. 2020. Cellular and molecular life sciences
UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells
Korhonen, Eveliina; Bisevac, Jovana; Hyttinen, Juha MT; Piippo, Niina; Hytti, Maria; Kaarniranta, Kai; Petrovski, Goran; Kauppinen, Anu. 2020. Investigative ophthalmology and visual science
AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging
Salminen, Antero; Kauppinen, Anu; Kaarniranta, Kai. 2019. Journal of molecular medicine: jmm
Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy
Hytti, Maria; Korhonen, Eveliina; Hyttinen, Juha M T; Roehrich, Heidi; Kaarniranta, Kai; Ferrington, Deborah A; Kauppinen, Anu. 2019. Oxidative medicine and cellular longevity
Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration
Kaarniranta, Kai; Koskela, Ali; Felszeghy, Szabolcs; Kivinen, Niko; Salminen, Antero; Kauppinen, Aanu. 2019. Biochimie
Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium-Role in Dead Cell Clearance and Inflammation
Szatmári-Tóth, M; Ilmarinen, T; Mikhailova, A; Skottman, H; Kauppinen, A; Kaarniranta, K; Kristóf, E; Lytvynchuk, L; Veréb, Z; Fésüs, L; Petrovski, G. 2019. International journal of molecular sciences
Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2019. Cellular and molecular life sciences
Life Style Intervention Improves Retinopathy Status - The Finnish Diabetes Prevention Study
Aro, A; Kauppinen, A; Kivinen, N; Selander, T; Kinnunen, K; Tuomilehto, J; Keinänen-Kiukaanniemi, S; Lindström, J; Uusitupa, M; Kaarniranta, K. 2019. Nutrients
SQSTM1/p62 regulates the production of IL-8 and MCP-1 in IL-1ß-stimulated human retinal pigment epithelial cells
Korhonen, E; Piippo, N; Hytti, M; Hyttinen, JMT; Kaarniranta, K; Kauppinen, A. 2019. Cytokine
Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage
Zeiner, J; Loukovaara, S; Losenkova, K; Zuccarini, M; Korhonen, AM; Lehti, K; Kauppinen, A; Kaarniranta, K; Müller, CE; Jalkanen, S; Yegutkin, GG. 2019. Journal of molecular medicine: jmm
Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways
Marchesi, Nicoletta; Thongon, Natthakan; Pascale, Alessia; Provenzani, Alessandro; Koskela, Ali; Korhonen, Eveliina; Smedowski, Adrian; Govoni, Stefano; Kauppinen, Anu; Kaarniranta, Kai; Amadio, Marialaura. 2018. Oxidative medicine and cellular longevity
Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome
Piippo, N; Korhonen, E; Hytti, M; Skottman, H; Kinnunen, K; Josifovska, N; Petrovski, G; Kaarniranta, K; Kauppinen, A. 2018. Scientific reports
Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. 2018. Redox biology
Mechanistical retinal drug targets and challenges
Kaarniranta; Kai; Xu, Heping; Kauppinen, Anu. 2018. Advanced drug delivery reviews
Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence
Salminen, Antero; Kauppinen, Anu; Kaarniranta, Kai. 2018. Biogerontology
NLRP3-inflammasomiaktivaatio diabeettisessa retinopatiassa
Kauppinen, Anu. 2018. BestPractice: Diabetes ja sydänsairaudet
Oxidative Stress is the Principal Contributor to Inflammasome Activation in Retinal Pigment Epithelium Cells with Defunct Proteasomes and Autophagy
Piippo, Niina; Korhonen, Eveliina; Hytti, Maria; Kinnunen, Kati; Kaarniranta, Kai; Kauppinen, Anu. 2018. Cellular physiology and biochemistry
Phytochemicals inhibit the immunosuppressive functions of myeloid-derived suppressor cells (MDSC): Impact on cancer and age-related chronic inflammatory disorders.
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2018. International immunopharmacology
The potential importance of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of Alzheimer's disease
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2018. Cellular and molecular life sciences
The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2018. Ageing research reviews
CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells
Hytti M, Andjelic S, Josifovska N, Piippo N, Korhonen E, Hawlina M, Kaarniranta K, Nevalainen TJ, Petrovski G, Parkkari T, Kauppinen A. 2017. Scientific reports
DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells - Implications for age-related macular degeneration (AMD)
Hyttinen JMT, Blasiak J, Niittykoski M, Kinnunen K, Kauppinen A, Salminen A, Kaarniranta K. 2017. Ageing research reviews
Hypoxia and inflammation in the release of VEGF and interleukins from human retinal pigment epithelial cells
Arjamaa Olli, Aaltonen Vesa, Piippo Niina, Csont Tamás, Petrovski Goran, Kaarniranta Kai, Kauppinen Anu. 2017. Graefes archive for clinical and experimental ophthalmology
Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease
Salminen Antero, Kauppinen Anu, Kaarniranta Kai. 2017. Journal of neurochemistry
Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity
Salminen A, Kaarniranta K, Kauppinen A. 2017. Cellular signalling
Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs)
Kinnunen K, Piippo N, Loukovaara S, Hytti M, Kaarniranta K, Kauppinen A. 2017. Journal of cell communication and signaling
Mitochondria-Associated Inflammasome Activation and Its Impact on Aging and Age-Related Diseases
Kauppinen Anu. 2017. Springer
NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy
Loukovaara S, Piippo N, Kinnunen K, Hytti M, Kaarniranta K, Kauppinen A. 2017. Acta ophthalmologica
Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses
Salminen Antero, Kaarniranta Kai, Kauppinen Anu. 2017. Ageing research reviews
Silmänpohjan ikärappeuman patogeneesi - autofagian ja inflammasomien vuoropuhelua
Kivinen Niko, Koskela Ali, Kauppinen Anu, Kaarniranta kai. 2017. Duodecim
The Nobel Prized cellular target autophagy in eye diseases
Kaarniranta Kai, Petrovski Goran, Kauppinen Anu. 2017. Acta ophthalmologica
Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cell
Hytti M, Szabó D, Piippo N, Korhonen E, Honkakoski P, Kaarniranta K, Petrovski G, Kauppinen A. 2017. Journal of nutritional biochemistry
AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms
Salminen Antero, Kaarniranta Kai, Kauppinen Anu. 2016. Biogerontology
AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions
Salminen Antero, Kauppinen Anu, Kaarniranta Kai. 2016. Cellular signalling
Absence of collagen XVIII in mice causes age-related insufficiency in retinal pigment epithelium proteostasis
Kivinen Niko, Felszeghy Szabolcs, Kinnunen Aino I, Setälä Niko, Aikio Mari, Kinnunen Kati, Sironen Reijo, Pihlajaniemi Taina, Kauppinen Anu, Kaarniranta Kai. 2016. Biogerontology
Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways
Salminen Antero, Kaarniranta Kai, Kauppinen Anu. 2016. Ageing research reviews
Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration
Szatmári-Tóth M, Kristóf E, Veréb Z, Akhtar S, Facskó A, Fésus L, Kauppinen A, Kaarniranta K, Petrovski G. 2016. Cell death and disease
FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process
Salminen Antero, Kauppinen Anu, Kaarniranta Kai. 2016. Journal of molecular medicine: jmm
Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases
Salminen Antero, Kaarniranta Kai, Kauppinen Anu. 2016. Aging and disease
Inflammation and its role in age-related macular degeneration
Kauppinen Anu, Paterno Jussi J, Blasiak Janusz, Salminen Antero, Kaarniranta Kai. 2016. Cellular and molecular life sciences
Inhibition of BET bromodomains alleviates inflammation in human RPE cells
Hytti Maria, Tokarz P, Määttä E, Piippo Niina, Korhonen Eveliina, Suuronen T, Honkakoski Paavo, Kaarniranta Kai, Lahtela-Kakkonen Maija, Kauppinen Anu. 2016. Biochemical pharmacology
Long-term topical application of preservative-free prostaglandin analogues evokes macrophage infiltration in the ocular adnexa
Trzeciecka Anna, Paterno J Jussi, Toropainen Elisa, Koskela Ali, Podracka Lucia, Korhonen Eveliina, Kauppinen Anu, Kaarniranta Kai, Smedowski Adrian. 2016. European journal of pharmacology
2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process
Salminen Antero, Kauppinen Anu, Kaarniranta Kai. 2015. Cellular and molecular life sciences
Cytotoxicity assessment of porous silicon microparticles for ocular drug delivery
Korhonen Eveliina, Rönkkö Seppo, Hillebrand Satu, Riikonen Joakim, Xu Wujun, Järvinen Kristiina, Lehto Vesa-Pekka, Kauppinen Anu. 2015. European journal of pharmaceutics and biopharmaceutics
Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation
Hytti Maria, Piippo Niina, Korhonen Eveliina, Honkakoski Paavo, Kaarniranta Kai, Kauppinen Anu. 2015. Scientific reports
Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape
Salminen Antero, Haapasalo Annakaisa, Kauppinen Anu, Kaarniranta Kai, Soininen Hilkka, Hiltunen Mikko. 2015. Progress in neurobiology
Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells
Hytti Maria, Piippo Niina, Salminen Antero, Honkakoski Paavo, Kaarniranta Kai, Kauppinen Anu. 2015. Experimental eye research
CB2 receptor as a potential target in age-related diseases
Kauppinen Anu, Nevalainen Tapio, Hytti Maria, Salminen Antero, Kaarniranta Kai, Parkkari Teija. 2014. Journal of biochemical and pharmacological research
Cationorm shows good tolerability on human HCE-2 corneal epithelial cell cultures
Kinnunen Kati, Kauppinen Anu, Piippo Niina, Koistinen Arto, Toropainen Elisa, Kaarniranta Kai. 2014. Experimental eye research
Decline in cellular clearance systems induces inflammasome signaling in human ARPE-19 cells
Piippo N, Korkmaz A, Hytti M, Kinnunen K, Salminen A, Atalay M, Kaarniranta K, Kauppinen A. 2014. Biochimica et biophysica acta: molecular cell research
Estrogen Signalling in the Pathogenesis of Age-Related Macular Degeneration
Kaarniranta Kai, Machalinska Anna, Veréb Zoltán, Salminen Antero, Petrovski Goran, Kauppinen Anu. 2014. Current eye research
Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process
Salminen Antero, Kaarniranta Kai, Hiltunen Mikko, Kauppinen Anu. 2014. Journal of molecular medicine: jmm
Hsp70 binds reversibly to proteasome inhibitor-induced protein aggregates and evades autophagic clearance in ARPE-19 cells
Kivinen Niko, Hyttinen Juha MT, Viiri Johanna, Paterno Jussi, Felszheghy Szabolcs, Kauppinen Anu, Salminen Antero, Kaarniranta Kai. 2014. Journal of biochemical and pharmacological research
Inflammaging Signaling in Health Span and Life Span Regulation: Next Generation Targets for Longevity
Salminen A, Kauppinen A, Kaarniranta K. 2014. Academic press
Krebs cycle dysfunction shapes epigenetic landscape of chromatin: Novel insights into mitochondrial regulation of aging process
Salminen Antero, Kaarniranta Kai, Hiltunen Mikko, Kauppinen Anu. 2014. Cellular signalling
Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process
Salminen Antero, Kauppinen Anu, Hiltunen Mikko, Kaarniranta Kai. 2014. Ageing research reviews
Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists
Yrjölä Sari, Sarparanta Mirkka, Airaksinen Anu J, Hytti Maria, Kauppinen Anu, Pasonen-Seppänen Sanna, Adinolfi Barbara, Nieri Paola, Manera Clementina, Keinänen Outi, Poso Antti, Nevalainen Tapio J, Parkkari Teija. 2014. European journal of pharmaceutical sciences
Upregulation of inflammatory genes in the nasal mucosa of patients undergoing endonasal dacryocystorhinostomy
Penttilä E, Hyttinen JMT, Hytti M, Kauppinen A, Smirnov G, Tuomilehto H, Seppä J, Nuutinen J, Kaarniranta K. 2014. Clinical ophthalmology
Antagonistic crosstalk between NF-kappaB and SIRT1 in the regulation of inflammation and metabolic disorders
Kauppinen A, Suuronen T, Ojala J, Kaarniranta K, Salminen A. 2013. Cellular signalling
Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration
Kaarniranta K, Sinha D, Blasiak J, Kauppinen A, Vereb Z, Salminen A, Boulton ME, Petrovski G. 2013. Autophagy
Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process
Salminen A, Kaarniranta K, Kauppinen A. 2013. Ageing research reviews
Cellular and molecular mechanisms of age-related macular degeneration: From impaired autophagy to neovascularization
Klettner A, Kauppinen A, Blasiak J, Roider J, Salminen A, Kaarniranta K. 2013. International journal of biochemistry and cell biology
Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process
Salminen A, Kaarniranta K, Kauppinen A. 2013. International journal of molecular sciences
Epigenetic regulation of ASC/TMS1 expression: potential role in apoptosis and inflammasome function
Salminen A, Kauppinen A, Hiltunen M, Kaarniranta K. 2013. Cellular and molecular life sciences
Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome
Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. 2013. Progress in neurobiology
Inflammation as a target of minocycline: special interest in the regulation of inflammasome signaling
Kauppinen A, Salminen A, Kaarniranta K. 2013. Inflammasome
Mitochondrial and nuclear DNA damage and repair in age-related macular degeneration
Blasiak J, Glowacki S, Kauppinen A, Kaarniranta K. 2013. International journal of molecular sciences
Oxidative DNA Damage and Proteostasis in Age-Related Macular Degeneration
Tokarz P, Kauppinen A, Kaarniranta K, Blasiak J. 2013. Journal of biochemical and pharmacological research
Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration
Kaarniranta K, Kauppinen A, Blasiak J, Salminen A. 2012. Future medicinal chemistry
Context-dependent regulation of autophagy by IKK-NF-kappaB signaling: Impact on the aging process
Salminen A, Hyttinen JMT, Kauppinen A, Kaarniranta K. 2012. International journal of cell biology
Emerging role of NF-kappaB signaling in the induction of senescence-associated secretory phenotype (SASP)
Salminen A, Kauppinen A, Kaarniranta K. 2012. Cellular signalling
Inflammaging: disturbed interplay between autophagy and inflammasomes
Salminen, A; Kaarniranta, K; Kauppinen, A. 2012. Aging
Mitochondrial dysfunction and oxidative stress active inflammasomes: impact on the aging process and age-related diseases
Salminen A, Ojala J, Kaarniranta K, Kauppinen A. 2012. Cellular and molecular life sciences
Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells - Implications for age-related macular degeneration (AMD)
Kauppinen A, Niskanen H, Suuronen T, Kinnunen K, Salminen A, Kaarniranta K. 2012. Immunology letters
Phytochemicals suppress nuclear factor-kappaB signaling: impact on health span and the aging process
Salminen A, Kauppinen A, Kaarniranta K. 2012. Current opinion in clinical nutrition and metabolic care
The preservative polyquaternium-1 increases cytoxicity and NF-kappaB linked inflammation in human corneal epithelial cells
Paimela, T; Ryhänen, T; Kauppinen, A; Marttila, L; Salminen, A; Kaarniranta, K. 2012. Molecular vision
Cis-urocanic acid inhibits SAPK/JNK signaling pathway in UV-B exposed human corneal epithelial cells in vitro
Jauhonen H-M, Kauppinen A, Paimela T, Laihia JK, Leino L, Salminen A, Kaarniranta K. 2011. Molecular vision
Cis-urocanic acid suppresses UV-B-induced interleukin-6 and -8 secretion and cytotoxicity in human corneal and conjunctival epithelial cells in vitro
Viiri J, Jauhonen HM, Kauppinen A, Ryhänen T, Paimela T, Hyttinen J, Sorri I, Laihia JK, Leino L, Kaarniranta K. 2009. Molecular vision
Clusterin: A forgotten player in Alzheimer's disease
Nuutinen T, Suuronen T, Kauppinen A, Salminen A. 2009. Brain research reviews
ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology
Salminen A, Kauppinen A, Suuronen T, Kaarniranta K, Ojala J. 2009. Journal of neuroinflammation
Inflammation in Alzheimer's disease: Amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors
Salminen A, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. 2009. Progress in neurobiology
Suboptimal recognition of a T cell epitope of the major dog allergen Can f 1 by human T cells
Juntunen R, Liukko A, Taivainen A, Närvänen A, Durand G, Kauppinen A, Nieminen A, Rytkönen-Nissinen M, Saarelainen S, Maillère B, Virtanen T, Kinnunen T. 2009. Molecular immunology
Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging
Salminen A, Huuskonen J, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. 2008. Ageing research reviews
Amyloid-beta oligomers set fire to inflammasomes and induce Alzherimer's pathology
Salminen A, Ojala J, Suuronen T, Kaarniranta K, Kauppinen A. 2008. Journal of cellular and molecular medicine
Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity
Saarelainen S, Rytkönen-Nissinen M, Rouvinen J, Taivainen A, Auriola S, Kauppinen A, Kinnunen T, Virtanen T. 2008. Clinical and experimental allergy
Immunotherapeutic potential of the immunodominant T-cell epitope of lipocalin allergen Bos d 2 and its analogues
Saarelainen SA, Kinnunen TT, Buhot C, Närvänen ATO, Kauppinen AK, Rytkönen-Nissinen MA, Maillere B, Virtanen TI. 2008. Immunology
Interaction of aging-associated signaling cascades: Inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1
Salminen A, Ojala J, Huuskonen J, Kauppinen A, Suuronen T, Kaarniranta K. 2008. Cellular and molecular life sciences
SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation?
Salminen A, Kauppinen A, Suuronen T, Kaarniranta K. 2008. Bioessays
Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy
Kinnunen T, Jutila K, Kwok WW, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Närvänen A, Taivainen A, Virtanen T. 2007. Journal of allergy and clinical immunology
The major horse allergen Equ c 1 contains one immunodominant region of T cell epitopes
Immonen A, Kinnunen T, Sirven P, Taivainen A, Houitte D, Peräsaari J, Närvänen A, Saarelainen S, Rytkönen- Nissinen M, Maillere B, Virtanen T. 2007. Clinical and experimental allergy
Use of multiple peptides containing T cell epitopes is a feasible approach for peptide-based immunotherapy in Can f 1 allergy
Immonnen AK, Taivainen AH, Närvänen ATO, Kinnunen TT, Saarelainen SA, Rytkönen-Nissinen MA, Virtanen TI. 2007. Immunology
Lipocalin Allergen-Induced T Cell Response. Prospects for Peptide-Based Immunotherapy
Kauppinen A. 2006. Kuopio University Publications D. Medical Sciences
Effects of short- and long-term ultraviolet B irradiation on the immune system of the common carp (Cyprinus carpio)
Markkula SE, Salo HM, Immonen AK, Jokinen EI. 2005. Photochemistry and photobiology
Immunomodulatory potential of heteroclitic analogs of the dominant T-cell epitope of lipocalin allergen Bos d 2 on specific T cells
Kinnunen T, Kwock WW, Närvänen A, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Taivainen A, Virtanen T. 2005. International immunology
T cell epitope-containing peptides of the major dog allergen can f 1 as candidates for allergen immunotherapy
Immonen A, Farci S, Taivainen A, Partanen J, Pouvelle-Moratille S, Närvänen A, Kinnunen T, Saarelainen S, Rytkönen-Nissinen M, Maillere B, Virtanen T. 2005. Journal of immunology
The DR4-DQ8 haplotype and a specific T cell receptor Vbeta T cell subset are associated with absence of allergy to Can f 1
Kinnunen T, Taivainen A, Partanen J, Immonen A, Saarelainen S, Rytkönen-Nissinen M, Rautiainen J, Virtanen T. 2005. Clinical and experimental allergy
Assessment of recombinant dog allergens Can f 1 and Can f 2 for the diagnosis of dog allergy
Saarelainen S, Taivainen A, Rytkönen-Nissinen M, Auriola S, Immonen A, Mäntyjärvi R, Rautiainen J, Kinnunen T, Virtanen T. 2004. Clinical and experimental allergy
Probing the mechanisms of low immunogenicity of a lipocalin allergen, Bos d 2, in a mouse model
Immonen A, Saarelainen S, Rautiainen J, Rytkönen-Nissinen M, Kinnunen T, Mäntyjärvi R, Virtanen T. 2003. Clinical and experimental allergy

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

Facebook Instagram YouTube LinkedIn Snapchat SoundCloud TikTok Vimeo

Accessibility statement
Cookie usage
Give feedback

Manage consent

We use cookies to optimize our website and our service.

Functional Functional Always active

The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.

Asetukset Asetukset

Tekninen tallennus tai pääsy on tarpeen laillisessa tarkoituksessa sellaisten asetusten tallentamiseen, joita tilaaja tai käyttäjä ei ole pyytänyt.

Statistics Statistics

The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you. Tekninen tallennus tai pääsy, jota käytetään yksinomaan anonyymeihin tilastollisiin tarkoituksiin. Ilman haastetta, Internet-palveluntarjoajasi vapaaehtoista suostumusta tai kolmannen osapuolen lisätietueita pelkästään tähän tarkoitukseen tallennettuja tai haettuja tietoja ei yleensä voida käyttää tunnistamaan sinua.

Marketing Marketing

The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.

Show preferences

{title} {title} {title}

Refine your search

Anu Kauppinen

Research groups

Keywords

Fibrotic Changes in Rhegmatogenous Retinal Detachment

Anti-inflammatory potential of simvastatin and amfenac in ARPE-19 cells; insights in preventing re-detachment and proliferative vitreoretinopathy after rhegmatogenous retinal detachment surgery

Epithelial-mesenchymal Transition (EMT) and the Effect of Atorvastatin on it in ARPE-19 cells

Metformin Alleviates Inflammation and Induces Mitophagy in Human Retinal Pigment Epithelium Cells Suffering from Mitochondrial Damage

Simvastatin and amfenac act as immunomodulators during induced epithelial‐mesenchymal transition in ARPE‐19 cells

The L-type amino acid transporter 1 enhances drug delivery to the mouse pancreatic beta cell line (MIN6)

Tissue fibroblasts are versatile immune regulators: An evaluation of their impact on the aging process

Autophagy in the eye: from physiology to pathophysology

Cis-urocanic acid improves cell viability and suppresses inflammasome activation in human retinal pigment epithelial cells

Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients

The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance

Amfenac together with simvastatin reduces IL-8 and MCP-1 and increases VEGF release from ARPE-19 cells upon inflammatory conditions

Askeleita kohti verkkokalvon irtauman jälkeisen arven lääkkeellistä estoa

Editorial: Regulation of inflammation and metabolism in retinal neurodegenerative disorders

Epoxomicin, a Selective Proteasome Inhibitor, Activates AIM2 Inflammasome in Human Retinal Pigment Epithelium Cells

Hydroquinone increases risk for retinal pigment epithelial (RPE) cell degeneration

Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions

L-type Amino Acid Transporter 1 Utilizing Ferulic Acid Derivatives Show Increased Drug Delivery in the Mouse Pancreas Along with Decreased Lipid Peroxidation and Prostaglandin Production

Phloretin inhibits glucose transport and reduces inflammation in human retinal pigment epithelial cells

Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin

Antimycin A-induced mitochondrial dysfunction regulates inflammasome signaling in human retinal pigment epithelial cells

Differential Expression of Inflammasome-Related Genes in Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells with or without History of Age-Related Macular Degeneration

Effects of Resvega on Inflammasome Activation in Conjunction with Dysfunctional Intracellular Clearance in Retinal Pigment Epithelial (RPE) Cells

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Hydroquinone Induces NLRP3-Independent IL-18 Release from ARPE-19 Cells

Hypoxia/ischemia impairs CD33 (Siglec-3)/TREM2 signaling: Potential role in Alzheimer's pathogenesis

Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases

Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1[alpha] -/- Mouse Model Evoke Complement Component C5a Independent of C3

Statins for the prevention of proliferative vitreoretinopathy: cellular responses in cultured cells and clinical statin concentrations in the vitreous

TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells

ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease

Exosomal vesicles enhance immunosuppression in chronic inflammation: Impact in cellular senescence and the aging process

Introduction to the multi-author review on macular degeneration

Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration

Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model

Only IL-1ß release is inflammasome-dependent upon ultraviolet B irradiation although IL-18 is also secreted

Potential Role of Myeloid-Derived Suppressor Cells (MDSCs) in Age-Related Macular Degeneration (AMD)

Theme issue on macular degeneration

UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells

AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging

Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy

Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration

Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium-Role in Dead Cell Clearance and Inflammation

Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency

Life Style Intervention Improves Retinopathy Status - The Finnish Diabetes Prevention Study

SQSTM1/p62 regulates the production of IL-8 and MCP-1 in IL-1ß-stimulated human retinal pigment epithelial cells

Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage

Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways

Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Mechanistical retinal drug targets and challenges

Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence

NLRP3-inflammasomiaktivaatio diabeettisessa retinopatiassa

Oxidative Stress is the Principal Contributor to Inflammasome Activation in Retinal Pigment Epithelium Cells with Defunct Proteasomes and Autophagy

Phytochemicals inhibit the immunosuppressive functions of myeloid-derived suppressor cells (MDSC): Impact on cancer and age-related chronic inflammatory disorders.

The potential importance of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of Alzheimer's disease

The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process

CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells

DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells - Implications for age-related macular degeneration (AMD)

Hypoxia and inflammation in the release of VEGF and interleukins from human retinal pigment epithelial cells

Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease

Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity

Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs)

Mitochondria-Associated Inflammasome Activation and Its Impact on Aging and Age-Related Diseases

NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy

Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses

Silmänpohjan ikärappeuman patogeneesi - autofagian ja inflammasomien vuoropuhelua

The Nobel Prized cellular target autophagy in eye diseases

Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cell

AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms

AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions

Absence of collagen XVIII in mice causes age-related insufficiency in retinal pigment epithelium proteostasis

Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways

Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration

FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process

Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases