ELISA TOROPAINEN

Yhteystiedot

Tutkimusryhmät - UEF

• 
  Silmälääketutkimusryhmä

Julkaisut

• del Amo, Eva M.; Hammid, Anam; Tausch, Melanie; Toropainen, Elisa; Sadeghi, Amir; Valtari, Annika; Puranen, Jooseppi; Reinisalo, Mika; Ruponen, Marika; Urtti, Arto; Sauer, Achim; Honkakoski, Paavo. 2022. Ocular metabolism and distribution of drugs in the rabbit eye: Quantitative assessment after intracameral and intravitreal administrations International journal of pharmaceutics 613: 121361. 2022
• Bassetto M, Ajoy D, Poulhes F, Obringer C, Walter A, Messadeq N, Sadeghi A, Puranen J, Ruponen M, Kettunen M, Toropainen E, Urtti A, Dollfus H, Zelphati O, Marion V. 2021. Magnetically Assisted Drug Delivery of Topical Eye Drops Maintains Retinal Function In Vivo in Mice Pharmaceutics 13 10: 1650. 2021
• Blasiak, Janusz; Koskela, Ali; Pawlowska, Elzbieta; Liukkonen, Mikko; Ruuth, Johanna; Toropainen, Elisa; Hyttinen, Juha MT; Viiri, Johanna; Eriksson, John E.; Xu, Heping; Chen, Mei; Felszeghy, Szabolcs; Kaarniranta, Kai. 2021. Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice International journal of molecular sciences 22 4: 1684. 2021
• Fayyaz, Anam; Vellonen, Kati-Sisko; Ranta, Veli-Pekka; Toropainen, Elisa; Reinisalo, Mika; Valtari, Annika; Puranen, Jooseppi; D'Amico Ricci, Giuseppe; Heikkinen, Emma M.; Gardner, Iain; Ruponen, Marika; Urtti, Arto; Jamei, Masoud; del Amo, Eva M. 2021. Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: tissue exposures in the rabbit eye European journal of pharmaceutics and biopharmaceutics 166: 155-162. 2021
• Junnuthula, Vijayabhaskarreddy; Sadeghi Boroujeni, Amir; Cao, Shoupeng; Tavakoli, Shirin; Ridolfo, Roxane; Toropainen, Elisa; Ruponen, Marika; van Hest, Jan CM; Urtti, Arto. 2021. Intravitreal Polymeric Nanocarriers with Long Ocular Retention and Targeted Delivery to the Retina and Optic Nerve Head Region Pharmaceutics 13 4: 445. 2021
• Sadeghi, Amir; Puranen, Jooseppi; Ruponen, Marika; Valtari, Annika; Subrizi, Astrid; Ranta, Veli-Pekka; Toropainen, Elisa; Urtti, Arto. 2021. Pharmacokinetics of intravitreal macromolecules: scaling between rats and rabbits European journal of pharmaceutical sciences 159: 105720. 2021
• Toropainen, Elisa; Fraser-Miller, Sara J; Novakovic, Dunja; Del Amo, Eva M; Vellonen, Kati-Sisko; Ruponen, Marika; Viitala, Tapani; Korhonen, Ossi; Auriola, Seppo; Hellinen, Laura; Reinisalo, Mika; Tengvall, Unni; Choi, Stephanie; Absar, Mohammad; Strachan, Clare; Urtti, Arto. 2021. Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin Pharmaceutics 13 4: 452. 2021
• Balla, Anusha; Auriola, Seppo; Grey, Angus C; Demarais, Nicholas J; Valtari, Annika; Heikkinen, Emma M; Toropainen, Elisa; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika. 2021. Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues Pharmaceutics 13 5: 658. 2021
• Itkonen, Jaakko; Annala, Ada; Tavakoli, Shirin; Arango-Gonzalez, Blanca; Ueffing, Marius; Toropainen, Elisa; Ruponen, Marika; Casteleijn, Marco G; Urtti, Arto. 2020. Characterization, Stability, and in Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation Into the Neural Retina in Ex Vivo Organotypic Retinal Explant Culture Models Pharmaceutics 12 7: E611. 2020
• Shakirova, Julia R; Sadeghi, Amir; Koblova, Alla A; Chelushkin, Pavel S; Toropainen, Elisa; Tavakoli, Shirin; Kontturi, Leena-Stiina; Lajunen, Tatu; Tunik, Sergey P; Urtti, Arto. 2020. Design and synthesis of lipid-mimetic cationic iridium complexes and their liposomal formulation for in vitro and in vivo application in luminescent bioimaging Rsc advances 10 24: 14431-14440. 2020
• Fayyaz, Anam; Ranta, Veli-Pekka; Toropainen, Elisa; Vellonen, Kati-Sisko; Valtari, Annika; Puranen, Jooseppi; Ruponen, Marika; Gardner, Iain; Urtti, Arto; Jamei, Masoud; del Amo, Eva M.. 2020. Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits European journal of pharmaceutical sciences 155: 105553. 2020
• Hemmilä, Samu; Ruponen, Marika; Toropainen, Elisa; Tengvall-Unadike, Unni; Urtti, Arto; Kallio, Pasi. 2020. Microflow-Based Device for In Vitro and Ex Vivo Drug Permeability Studies SLAS technology 25 5: 455-462. 2020
• Bhattacharya, Madhushree; Sadeghi, Amir; Sarkhel, Sanjay; Hagström, Marja; Bahrpeyma, Sina; Toropainen, Elisa; Auriola, Seppo; Urtti, Arto. 2020. Release of functional dexamethasone by intracellular enzymes: A modular peptide-based strategy for ocular drug delivery Journal of controlled release 327: 584-594. 2020
• Fayyaz, A; Ranta, VP; Toropainen, E; Vellonen, KS; Ricci, GD; Reinisalo, M; Heikkinen, EM; Gardner, I; Urtti, A; Jamei, M; del Amo, EM. 2019. Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits Molecular pharmaceutics 12 4: e007045. 2019
• Heikkinen, EM; Auriola, S; Ranta, VP; Demarais, N; Grey, A; Del Amo, E; Toropainen, E; Vellonen, KS; Urtti, A; Ruponen, M. 2019. Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics Molecular pharmaceutics 16 9: 3968-3976. 2019
• Kalinin, Stanislav; Valtari, Annika; Ruponen, Marika; Toropainen, Elisa; Kovalenko, Alexander; Nocentini, Alessio; Gureev, Maxim; Dar'in, Dmitry; Urtti, Arto; Supuran, Claudiu T; Krasavin, Mikhail. 2019. Highly Hydrophilic 1,3-Oxazol-5-yl Benzenesulfonamide Inhi bitors of Carbonic Anhydrase II for Reduction of Glaucoma-Related Intraocular Pressure Bioorganic and medicinal chemistry 27 11: 115086. 2019
• Ramsay, E; Hagström, M; Vellonen, KS; Boman, S; Toropainen, E; Del Amo, EM; Kidron, H; Urtti, A; Ruponen, M. 2019. Role of retinal pigment epithelium permeability in drug transfer between posterior eye segment and systemic blood circulation European journal of pharmaceutics and biopharmaceutics 143: 18-23. 2019
• Smedowski, A; Akhtar, S; Liu, X; Pietrucha-Dutczak, M; Podracka, L; Toropainen, E; Alkanaan, A; Ruponen, M; Urtti, A; Varjosalo, M; Kaarniranta, K; Lewin-Kowalik, J. 2019. Electrical synapses interconnecting axons revealed in the optic nerve head - a novel model of gap junctions' involvement in optic nerve function Acta ophthalmologica [Epub ahead of print 10 Oct 2019]: 1-10. 2019
• Ramsay, Eva; del Amo, Eva M; Toropainen, Elisa; Tengvall-Unadike, Unni; Ranta, Veli-Pekka; Urtti, Arto; Ruponen, Marika. 2018. Corneal and conjunctival drug permeability : systematic comparison and pharmacokinetic impact in the eye European journal of pharmaceutical sciences 119: 83-89. 2018
• Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. 2018. Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration Redox biology 2019; 20: 1-12. 2018
• del Amo Eva M, Rimpelä Anna-Kaisa, Heikkinen Emma, Kari Otto K, Ramsay Eva, Lajunen Tatu, Schmitt Mechthild, Pelkonen Laura, Bhattacharya Madhushree, Richardson Dominique, Subrizi Astrid, Turunen Tiina, Reinisalo Mika, Itkonen Jaakko, Toropainen Elisa, Casteleijn Marco, Kidron Heidi, Antopolsky Maxim, Vellonen Kati-Sisko, Ruponen Marika, et al.. 2017. Pharmacokinetic aspects of retinal drug delivery PROGRESS IN RETINAL AND EYE RESEARCH 57: 134-185. 2017
• Ramsay E, Ruponen M, Picardat T, Tengvall U, Tuomainen M, Auriola S, Toropainen E, Urtti A, del Amo EM. 2017. Impact of Chemical Structure on Conjunctival Drug Permeability: Adopting Porcine Conjunctiva and Cassette Dosing for Construction of In Silico Model. JOURNAL OF PHARMACEUTICAL SCIENCES 106 9: 2463-2471. 2017
• Rönkkö Seppo, Vellonen Kati-Sisko, Järvinen Kristiina, Toropainen Elisa, Urtti Arto. 2016. Human corneal cell culture models for drug toxicity studies. Drug Delivery and Translational Research 6 6: 660-675. 2016
• Trzeciecka Anna, Paterno J Jussi, Toropainen Elisa, Koskela Ali, Podracka Lucia, Korhonen Eveliina, Kauppinen Anu, Kaarniranta Kai, Smedowski Adrian. 2016. Long-term topical application of preservative-free prostaglandin analogues evokes macrophage infiltration in the ocular adnexa European journal of pharmacology 788: 12-20. 2016
• Kinnunen Kati, Kauppinen Anu, Piippo Niina, Koistinen Arto, Toropainen Elisa, Kaarniranta Kai. 2014. Cationorm shows good tolerability on human HCE-2 corneal epithelial cell cultures. EXPERIMENTAL EYE RESEARCH 120: 82-89. 2014
• Smedowski Adrian, Paterno Jussi J, Toropainen Elisa,Sinha Debasish, Wylegala Edward, Kaarniranta Kai. 2014. Excipients of preservative-free latanoprost induced inflammatory response and cytotoxicity in immortalized human HCE-2 corneal epithelial cells Journal of biochemical and pharmacological research 2 4: 175-184. 2014
• Subrizi Astrid, Toropainen Elisa, Ramsay Eva, Airaksinen Anu J, Kaarniranta Kai, Urtti Arto. 2014. Oxidative Stress Protection by Exogenous Delivery of rhHsp70 Chaperone to the Retinal Pigment Epithelium (RPE), a Possible Therapeutic Strategy Against RPE Degeneration. PHARMACEUTICAL RESEARCH 2015; 32: 211-221. 2014
• Vellonen Kati-Sisko, Malinen Melina, Mannermaa Eliisa, Subrizi Astrid, Toropainen Elisa, Lou Yan-Ru, Kidron Heidi, Yliperttula Marjo, Urtti Arto. 2014. A critical assessment of in vitro tissue models for ADME and drug delivery. JOURNAL OF CONTROLLED RELEASE 190: 94-114. 2014
• Salminen A, Kauppinen A, Hyttinen JMT, Toropainen E & Kaarniranta K. 2010. Endoplasmic reticulum stress in age-related macular degeneration: Trigger for neovascularization MOLECULAR MEDICINE TODAY 16 11-12: 535-542. 2010
• Toropainen E, Hornof M, Kaarniranta K, Johansson P, Urtti A. 2007. Corneal epithelium as a platform for secretion of transgene products after transfection with liposomal gene eyedrops. JOURNAL OF GENE MEDICINE 9: 208-216. 2007
• Toropainen E. 2007. Corneal Epithelial Cell Culture Model for Pharmaceutical Studies. Kuopion yliopiston julkaisuja A. Farmaseuttiset tieteet. 2007
• Hornof M, Toropainen E, Urtti A. 2005. Cell culture models of the ocular barriers EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 60: 207-225. 2005
• Ranta V-P, Laavola M, Toropainen E, Vellonen K-S, Talvitie A, Urtti A. 2003. Ocular pharmacokinetic modeling using corneal absorption and desorption rates from in vitro permeation experiments with cultured corneal epithelial cells. PHARMACEUTICAL RESEARCH 20 9: 1409-1416. 2003
• Toropainen E, Ranta V-P, Vellonen K-S, Palmgrén J, Talvitie A, Laavola M, Suhonen P, Hämäläinen KM, Auriola S, Urtti A. 2003. Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 20: 99-106. 2003
• Palmgrén JJ, Toropainen E, Auriola S, Urtti A. 2002. Liquid chromatographic-electrospray ionization mass spectrometric analysis of neutral and charged polyethylene glycols. JOURNAL OF CHROMATOGRAPHY A 976: 165-170. 2002
• Ranta V-P, Toropainen E, Talvitie A, Auriola S, Urtti A. 2002. Simultaneous determination of eight beta-blockers by gradient high-performance liquid chromatography with combined ultraviolet and fluorescence detection in corneal permeability studies in vitro. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 772: 81-87. 2002
• Toropainen E, Ranta V-P, Talvitie A, Suhonen P, Urtti A. 2001. Culture model of human corneal epithelium for prediction of ocular drug absorption. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 42 12: 2942-2948. 2001
• Toropainen E, Lipponen P, Syrjänen K. 1995. Expression of insulin-like growth factor I (IGF-I) in female breast cancer as related to established prognostic factors and long-term prognosis. EUROPEAN JOURNAL OF CANCER 31A 9: 1443-1448. 1995